BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 46023 CC1Nc2nc(NC(=O)c3ccc[n+](C)c3)[nH]c(=O)c2N(C1C)C(=O)c1ccc[n+](C)c1 InChI=1S/C22H23N7O3/c1-13-14(2)29(21(32)16-8-6-10-28(4)12-16)17-18(23-13)24-22(26-20(17)31)25-19(30)15-7-5-9-27(3)11-15/h5-14H,1-4H3,(H-2,23,24,25,26,30,31)/p+2 DBUKPVKCXJMBPN-UHFFFAOYSA-P 25377 3-({6,7-dimethyl-5-[(1-methylpyridin-1-ium-3-yl)carbonyl]-4-oxo-3,4,5,6,7,8-hexahydropteridin-2-yl}carbamoyl)-1-methylpyridin-1-ium::4-oxo-3,4,5,6,7,8-hexahydropteridine, 1 Serine/threonine-protein kinase B-raf Homo sapiens 29420 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25377&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 4307357 56374516 ZINC00719489 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46024 Cn1c2[nH]c(=S)n(Cc3ccc(Cl)cc3)c2c(=O)[nH]c1=O InChI=1S/C13H11ClN4O2S/c1-17-10-9(11(19)16-12(17)20)18(13(21)15-10)6-7-2-4-8(14)5-3-7/h2-5H,6H2,1H3,(H,15,21)(H,16,19,20) AFCLEMNPGSUBDT-UHFFFAOYSA-N 25378 7-[(4-chlorophenyl)methyl]-3-methyl-8-sulfanyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione::purine-2,6-dione, 19 Serine/threonine-protein kinase B-raf Homo sapiens 2100 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25378&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 741849 56374517 ZINC05730882 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46025 CSc1nc2n(C)c(=O)[nH]c(=O)c2n1Cc1ccccc1 InChI=1S/C14H14N4O2S/c1-17-11-10(12(19)16-13(17)20)18(14(15-11)21-2)8-9-6-4-3-5-7-9/h3-7H,8H2,1-2H3,(H,16,19,20) VVFPFPZPOHNMBQ-UHFFFAOYSA-N 25379 7-benzyl-3-methyl-8-(methylsulfanyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione::purine-2,6-dione, 22 Serine/threonine-protein kinase B-raf Homo sapiens 30110 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25379&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 817983 56374518 ZINC00332381 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46026 C\C(Cl)=C/CSc1nc2n(C)c(=O)n(Cc3ccccc3)c(=O)c2n1Cc1ccccc1 InChI=1S/C24H23ClN4O2S/c1-17(25)13-14-32-23-26-21-20(28(23)15-18-9-5-3-6-10-18)22(30)29(24(31)27(21)2)16-19-11-7-4-8-12-19/h3-13H,14-16H2,1-2H3/b17-13+ ILBOKBKKRWRYIJ-GHRIWEEISA-N 25380 1,7-dibenzyl-8-{[(2E)-3-chlorobut-2-en-1-yl]sulfanyl}-3-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione::purine-2,6-dione, 23 Serine/threonine-protein kinase B-raf Homo sapiens 10910 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25380&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 5753938 56374519 ZINC08434860 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46027 Cn1c2nc(SCCO)n(Cc3ccccc3)c2c(=O)n(Cc2ccccc2)c1=O InChI=1S/C22H22N4O3S/c1-24-19-18(20(28)26(22(24)29)15-17-10-6-3-7-11-17)25(21(23-19)30-13-12-27)14-16-8-4-2-5-9-16/h2-11,27H,12-15H2,1H3 VTFCZAWGUWVLNZ-UHFFFAOYSA-N 25381 1,7-dibenzyl-8-[(2-hydroxyethyl)sulfanyl]-3-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione::purine-2,6-dione, 24 Serine/threonine-protein kinase B-raf Homo sapiens 106 1720 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25381&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 3106064 56374520 ZINC02361683 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46028 Cn1c2nc(SCC(N)=O)n(Cc3cccc(Br)c3)c2c(=O)[nH]c1=O InChI=1S/C15H14BrN5O3S/c1-20-12-11(13(23)19-14(20)24)21(15(18-12)25-7-10(17)22)6-8-3-2-4-9(16)5-8/h2-5H,6-7H2,1H3,(H2,17,22)(H,19,23,24) HKKJJBUQMXEHOW-UHFFFAOYSA-N 25382 2-({7-[(3-bromophenyl)methyl]-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl}sulfanyl)acetamide::purine-2,6-dione, 25 Serine/threonine-protein kinase B-raf Homo sapiens 11080 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25382&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 985658 56374521 ZINC00632706 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46029 CC(N=Nc1nc2n(C)c(=O)[nH]c(=O)c2n1Cc1ccccc1)c1ccc(cc1)[N+]([O-])=O InChI=1S/C21H19N7O4/c1-13(15-8-10-16(11-9-15)28(31)32)24-25-20-22-18-17(19(29)23-21(30)26(18)2)27(20)12-14-6-4-3-5-7-14/h3-11,13H,12H2,1-2H3,(H,23,29,30) YUBXYZWSOMHUSV-UHFFFAOYSA-N 25383 7-benzyl-3-methyl-8-[(2Z)-2-[1-(4-nitrophenyl)ethylidene]hydrazin-1-yl]-2,3,6,7-tetrahydro-1H-purine-2,6-dione::purine-2,6-dione, 26 Serine/threonine-protein kinase B-raf Homo sapiens 4600 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25383&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896013 56374522 ZINC33909278 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46030 Cc1cc(C)n(n1)-c1nc2n(C)c(=O)n(C)c(=O)c2n1Cc1ccccc1 InChI=1S/C19H20N6O2/c1-12-10-13(2)25(21-12)18-20-16-15(17(26)23(4)19(27)22(16)3)24(18)11-14-8-6-5-7-9-14/h5-10H,11H2,1-4H3 XHYOYBRJYJGKJZ-UHFFFAOYSA-N 25384 7-benzyl-8-(3,5-dimethyl-1H-pyrazol-1-yl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione::purine-2,6-dione, 27 Serine/threonine-protein kinase B-raf Homo sapiens 57710 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25384&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25023945 56374523 ZINC12231347 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46031 C\C(Cl)=C/CSc1nc2n(C)c(=O)[nH]c(=O)c2n1CC(O)CCc1ccccc1 InChI=1S/C20H23ClN4O3S/c1-13(21)10-11-29-20-22-17-16(18(27)23-19(28)24(17)2)25(20)12-15(26)9-8-14-6-4-3-5-7-14/h3-7,10,15,26H,8-9,11-12H2,1-2H3,(H,23,27,28)/b13-10+ SCRFATXHLQNDDY-JLHYYAGUSA-N 25385 8-{[(2E)-3-chlorobut-2-en-1-yl]sulfanyl}-7-(2-hydroxy-4-phenylbutyl)-3-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione::purine-2,6-dione, 28 Serine/threonine-protein kinase B-raf Homo sapiens 3750 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25385&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25023946 56374524 ZINC40394160 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46032 Cn1c2nc(N=NCc3cccc(c3)[N+]([O-])=O)n(CC=C)c2c(=O)[nH]c1=O InChI=1S/C16H15N7O4/c1-3-7-22-12-13(21(2)16(25)19-14(12)24)18-15(22)20-17-9-10-5-4-6-11(8-10)23(26)27/h3-6,8H,1,7,9H2,2H3,(H,19,24,25) OSOLAGBLMDUURC-UHFFFAOYSA-N 25386 3-methyl-8-[(2Z)-2-[(3-nitrophenyl)methylidene]hydrazin-1-yl]-7-(prop-2-en-1-yl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione::purine-2,6-dione, 29 Serine/threonine-protein kinase B-raf Homo sapiens 37480 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25386&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896014 56374525 ZINC33334845 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46033 CC(N=Nc1nc2n(C)c(=O)[nH]c(=O)c2n1C\C=C(\C)Cl)c1ccc(cc1)[N+]([O-])=O InChI=1S/C18H18ClN7O4/c1-10(19)8-9-25-14-15(24(3)18(28)21-16(14)27)20-17(25)23-22-11(2)12-4-6-13(7-5-12)26(29)30/h4-8,11H,9H2,1-3H3,(H,21,27,28)/b10-8-,23-22? CAKPSZHPTYIVEW-UHKNWHIESA-N 25387 7-[(2Z)-3-chlorobut-2-en-1-yl]-3-methyl-8-[(2Z)-2-[1-(4-nitrophenyl)ethylidene]hydrazin-1-yl]-2,3,6,7-tetrahydro-1H-purine-2,6-dione::purine-2,6-dione, 30 Serine/threonine-protein kinase B-raf Homo sapiens 17360 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25387&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896015 56374526 ZINC05220289 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46034 Cn1c2nc(N=NCc3cccc(c3)[N+]([O-])=O)n(Cc3ccccc3)c2c(=O)[nH]c1=O InChI=1S/C20H17N7O4/c1-25-17-16(18(28)23-20(25)29)26(12-13-6-3-2-4-7-13)19(22-17)24-21-11-14-8-5-9-15(10-14)27(30)31/h2-10H,11-12H2,1H3,(H,23,28,29) GYIBSOGSTAFTBH-UHFFFAOYSA-N 25388 7-benzyl-3-methyl-8-[(2Z)-2-[(3-nitrophenyl)methylidene]hydrazin-1-yl]-2,3,6,7-tetrahydro-1H-purine-2,6-dione::purine-2,6-dione, 31 Serine/threonine-protein kinase B-raf Homo sapiens >50000 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25388&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896016 56374527 ZINC33909276 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46035 Cn1c2nc(N=NCc3ccc(cc3)[N+]([O-])=O)n(Cc3ccccc3)c2c(=O)[nH]c1=O InChI=1S/C20H17N7O4/c1-25-17-16(18(28)23-20(25)29)26(12-14-5-3-2-4-6-14)19(22-17)24-21-11-13-7-9-15(10-8-13)27(30)31/h2-10H,11-12H2,1H3,(H,23,28,29) DDLKGIKNXSKWPC-UHFFFAOYSA-N 25389 7-benzyl-3-methyl-8-[(2Z)-2-[(4-nitrophenyl)methylidene]hydrazin-1-yl]-2,3,6,7-tetrahydro-1H-purine-2,6-dione::purine-2,6-dione, 32 Serine/threonine-protein kinase B-raf Homo sapiens 57890 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25389&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896017 56374528 ZINC33909280 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46036 CC(N=Nc1nc2n(C)c(=O)[nH]c(=O)c2n1Cc1ccccc1)c1ccccc1 InChI=1S/C21H20N6O2/c1-14(16-11-7-4-8-12-16)24-25-20-22-18-17(19(28)23-21(29)26(18)2)27(20)13-15-9-5-3-6-10-15/h3-12,14H,13H2,1-2H3,(H,23,28,29) IZILBHQYAZKAKW-UHFFFAOYSA-N 25390 7-benzyl-3-methyl-8-[(2Z)-2-(1-phenylethylidene)hydrazin-1-yl]-2,3,6,7-tetrahydro-1H-purine-2,6-dione::purine-2,6-dione, 33 Serine/threonine-protein kinase B-raf Homo sapiens 11360 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25390&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896018 56374529 ZINC04780814 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46037 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 38 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46038 CN(C)CCOc1ccc(cc1)-c1nc(c([nH]1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1 InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,24H,6,10,15-16H2,1-2H3,(H,29,30) ZLWRKMXLUCZVAR-UHFFFAOYSA-N 25391 CHEMBL200622::SB-590885::SB590885::[2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)-1H-imidazol-2-yl}phenoxy)ethyl]dimethylamine Serine/threonine-protein kinase B-raf Homo sapiens 0.16 7 37.00 C Curated from the literature by BindingDB 10.1021/jm800539g 10.7270/Q2BC3WVM 18783202 aid1798548 Luo, C; Xie, P; Marmorstein, R University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25391&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2FB8 91369525 56374530 CHEMBL200622 ZINC89224159 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47332 CN(C)CCOc1ccc(cc1)-c1nc(c([nH]1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1 InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,24H,6,10,15-16H2,1-2H3,(H,29,30) ZLWRKMXLUCZVAR-UHFFFAOYSA-N 25391 CHEMBL200622::SB-590885::SB590885::[2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)-1H-imidazol-2-yl}phenoxy)ethyl]dimethylamine Serine/threonine-protein kinase B-raf Homo sapiens 0.3 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25391&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2FB8 91369525 56374530 CHEMBL200622 ZINC89224159 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47333 Oc1cc(ccc1Cl)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24) WXJLXRNWMLWVFB-UHFFFAOYSA-N 26041 2-chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol::2-chloro-5-[2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl]phenol::CHEMBL373011::L-779,450::L-779450 Serine/threonine-protein kinase B-raf Homo sapiens 2.4 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26041&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9950176 56464478 CHEMBL373011 ZINC28563889 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47334 CC(COc1nccc(n1)-c1nc(c([nH]1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1)N(C)C InChI=1S/C26H27N7O2/c1-16(33(2)3)15-35-26-28-13-10-22(29-26)25-30-23(17-8-11-27-12-9-17)24(31-25)19-4-6-20-18(14-19)5-7-21(20)32-34/h4,6,8-14,16,21H,5,7,15H2,1-3H3,(H,30,31) RJWYJMBVHFBGLF-UHFFFAOYSA-N 26042 imidazole-based compound, 3::{1-[(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)-1H-imidazol-2-yl}pyrimidin-2-yl)oxy]propan-2-yl}dimethylamine Serine/threonine-protein kinase B-raf Homo sapiens 0.5 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26042&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896047 56464479 ZINC40407755 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47335 CC(C)(CN)c1nc(c([nH]1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1 InChI=1S/C21H23N5O/c1-21(2,12-22)20-24-18(13-7-9-23-10-8-13)19(25-20)15-3-5-16-14(11-15)4-6-17(16)26-27/h3,5,7-11,17H,4,6,12,22H2,1-2H3,(H,24,25) OMJMHTPIOZMTTC-UHFFFAOYSA-N 26043 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)-1H-imidazol-2-yl}-2-methylpropan-1-amine::imidazole-based compound, 4 Serine/threonine-protein kinase B-raf Homo sapiens 4.9 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26043&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91501740 56464480 ZINC40918549 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47336 O=NC1CCc2cc(ccc12)-c1[nH]c(nc1-c1ccncc1)C1CCNCC1 InChI=1S/C22H23N5O/c28-27-19-4-2-16-13-17(1-3-18(16)19)21-20(14-5-9-23-10-6-14)25-22(26-21)15-7-11-24-12-8-15/h1,3,5-6,9-10,13,15,19,24H,2,4,7-8,11-12H2,(H,25,26) YPUCRGLYZSAWRC-UHFFFAOYSA-N 26044 (1E)-5-[2-(piperidin-4-yl)-5-(pyridin-4-yl)-1H-imidazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::imidazole-based compound, 5 Serine/threonine-protein kinase B-raf Homo sapiens 1.7 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26044&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73010396 56464481 ZINC03943386 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47337 COCCN1CCC(CC1)c1nc(c([nH]1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1 InChI=1S/C25H29N5O2/c1-32-15-14-30-12-8-18(9-13-30)25-27-23(17-6-10-26-11-7-17)24(28-25)20-2-4-21-19(16-20)3-5-22(21)29-31/h2,4,6-7,10-11,16,18,22H,3,5,8-9,12-15H2,1H3,(H,27,28) LKKMVUNOHJNJPK-UHFFFAOYSA-N 26045 (1E)-5-{2-[1-(2-methoxyethyl)piperidin-4-yl]-5-(pyridin-4-yl)-1H-imidazol-4-yl}-2,3-dihydro-1H-indene-1-hydroxylamine::imidazole-based compound, 6 Serine/threonine-protein kinase B-raf Homo sapiens 6.3 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26045&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91203188 56464482 ZINC40916417 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47338 O=NC1CCc2cc(ccc12)-c1[nH]c(CN2CCOCC2)nc1-c1ccncc1 InChI=1S/C22H23N5O2/c28-26-19-4-2-16-13-17(1-3-18(16)19)22-21(15-5-7-23-8-6-15)24-20(25-22)14-27-9-11-29-12-10-27/h1,3,5-8,13,19H,2,4,9-12,14H2,(H,24,25) VMHUMZQLFVVMEX-UHFFFAOYSA-N 26046 (1E)-5-[2-(morpholin-4-ylmethyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::imidazole-based compound, 7 Serine/threonine-protein kinase B-raf Homo sapiens 15.8 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26046&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90747418 56464483 ZINC40918516 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47339 O=NC1CCc2cc(ccc12)-c1[nH]c(nc1-c1ccncc1)C(=O)NCCN1CCOCC1 InChI=1S/C24H26N6O3/c31-24(26-9-10-30-11-13-33-14-12-30)23-27-21(16-5-7-25-8-6-16)22(28-23)18-1-3-19-17(15-18)2-4-20(19)29-32/h1,3,5-8,15,20H,2,4,9-14H2,(H,26,31)(H,27,28) IRBGRSTUDYOWRY-UHFFFAOYSA-N 26047 4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-N-[2-(morpholin-4-yl)ethyl]-5-(pyridin-4-yl)-1H-imidazole-2-carboxamide::imidazole-based compound, 8 Serine/threonine-protein kinase B-raf Homo sapiens 1.4 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26047&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90709673 56464484 ZINC04836250 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47340 CN(C)Cc1cccc(NC(=O)c2nc(c([nH]2)-c2ccc3C(CCc3c2)N=O)-c2ccncc2)c1 InChI=1S/C27H26N6O2/c1-33(2)16-17-4-3-5-21(14-17)29-27(34)26-30-24(18-10-12-28-13-11-18)25(31-26)20-6-8-22-19(15-20)7-9-23(22)32-35/h3-6,8,10-15,23H,7,9,16H2,1-2H3,(H,29,34)(H,30,31) CFVNLPYAPUWEPE-UHFFFAOYSA-N 26048 N-{3-[(dimethylamino)methyl]phenyl}-4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)-1H-imidazole-2-carboxamide::imidazole-based compound, 9 Serine/threonine-protein kinase B-raf Homo sapiens 1.3 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26048&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896048 56464485 ZINC40403702 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47341 CN(C)CCOc1ccc(cc1)-c1cc(c(o1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C28H27N3O3/c1-31(2)15-16-33-23-7-3-19(4-8-23)27-18-25(28(34-27)20-11-13-29-14-12-20)22-5-9-24-21(17-22)6-10-26(24)30-32/h3-5,7-9,11-14,17-18,26H,6,10,15-16H2,1-2H3 FQJVPSLTXAODEC-UHFFFAOYSA-N 26049 [2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)furan-2-yl}phenoxy)ethyl]dimethylamine::furan-based compound, 10 Serine/threonine-protein kinase B-raf Homo sapiens 0.5 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26049&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90803372 56464486 ZINC14019166 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47342 CN(C)CCOc1ccc(cc1)-c1cc(c([nH]1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C28H28N4O2/c1-32(2)15-16-34-23-7-3-19(4-8-23)27-18-25(28(30-27)20-11-13-29-14-12-20)22-5-9-24-21(17-22)6-10-26(24)31-33/h3-5,7-9,11-14,17-18,26,30H,6,10,15-16H2,1-2H3 XKARLDWQFOCEBP-UHFFFAOYSA-N 26050 [2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)-1H-pyrrol-2-yl}phenoxy)ethyl]dimethylamine::pyrrole-based compound, 11 Serine/threonine-protein kinase B-raf Homo sapiens 0.7 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26050&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91336164 56464487 ZINC62232948 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47343 CN(C)CCOc1ccc(cc1)-c1cc(c(o1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1 InChI=1S/C28H27N3O3/c1-31(2)15-16-33-23-7-3-20(4-8-23)27-18-25(19-11-13-29-14-12-19)28(34-27)22-5-9-24-21(17-22)6-10-26(24)30-32/h3-5,7-9,11-14,17-18,26H,6,10,15-16H2,1-2H3 LRJCNTQGXRSDNN-UHFFFAOYSA-N 26051 [2-(4-{5-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-4-(pyridin-4-yl)furan-2-yl}phenoxy)ethyl]dimethylamine::furan-based compound, 12 Serine/threonine-protein kinase B-raf Homo sapiens 0.9 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26051&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90842208 56464488 ZINC62232951 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47344 CN(C)CCOc1ccc(cc1)-c1cc(c([nH]1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1 InChI=1S/C28H28N4O2/c1-32(2)15-16-34-23-7-3-20(4-8-23)27-18-25(19-11-13-29-14-12-19)28(30-27)22-5-9-24-21(17-22)6-10-26(24)31-33/h3-5,7-9,11-14,17-18,26,30H,6,10,15-16H2,1-2H3 ZAGZDPPXYNVHHN-UHFFFAOYSA-N 26052 [2-(4-{5-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-4-(pyridin-4-yl)-1H-pyrrol-2-yl}phenoxy)ethyl]dimethylamine::pyrrole-based compound, 13 Serine/threonine-protein kinase B-raf Homo sapiens 2.4 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26052&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90799884 56464489 ZINC62232956 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47345 O=NC1CCc2cc(ccc12)-c1cc(oc1-c1ccncc1)C1CCNCC1 InChI=1S/C23H23N3O2/c27-26-21-4-2-17-13-18(1-3-19(17)21)20-14-22(15-5-9-24-10-6-15)28-23(20)16-7-11-25-12-8-16/h1,3,7-8,11-15,21,24H,2,4-6,9-10H2 YERYFQKNIBQWGZ-UHFFFAOYSA-N 26053 (1E)-5-[5-(piperidin-4-yl)-2-(pyridin-4-yl)furan-3-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::furan-based compound, 14 Serine/threonine-protein kinase B-raf Homo sapiens 2.4 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26053&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91126317 56464490 ZINC04836270 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47346 COCCN1CCC(CC1)c1cc(c(o1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C26H29N3O3/c1-31-15-14-29-12-8-18(9-13-29)25-17-23(26(32-25)19-6-10-27-11-7-19)21-2-4-22-20(16-21)3-5-24(22)28-30/h2,4,6-7,10-11,16-18,24H,3,5,8-9,12-15H2,1H3 HOPNPVRNOCAVHR-UHFFFAOYSA-N 26054 (1E)-5-{5-[1-(2-methoxyethyl)piperidin-4-yl]-2-(pyridin-4-yl)furan-3-yl}-2,3-dihydro-1H-indene-1-hydroxylamine::furan-based compound, 15 Serine/threonine-protein kinase B-raf Homo sapiens 2.7 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26054&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91427294 56464491 ZINC40404972 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47347 CN(C)CCNC(=O)c1cc(c(o1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C23H24N4O3/c1-27(2)12-11-25-23(28)21-14-19(22(30-21)15-7-9-24-10-8-15)17-3-5-18-16(13-17)4-6-20(18)26-29/h3,5,7-10,13-14,20H,4,6,11-12H2,1-2H3,(H,25,28) TWWYSBDKJOLFJP-UHFFFAOYSA-N 26055 N-[2-(dimethylamino)ethyl]-4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)furan-2-carboxamide::furan-based compound, 16 Serine/threonine-protein kinase B-raf Homo sapiens 0.5 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26055&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91391208 56464492 ZINC40407219 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 47348 O=NC1CCc2cc(ccc12)-c1cc(CN2CCOCC2)oc1-c1ccncc1 InChI=1S/C23H23N3O3/c27-25-22-4-2-17-13-18(1-3-20(17)22)21-14-19(15-26-9-11-28-12-10-26)29-23(21)16-5-7-24-8-6-16/h1,3,5-8,13-14,22H,2,4,9-12,15H2 LMSIQLBHZSSPIK-UHFFFAOYSA-N 26056 (1E)-5-[5-(morpholin-4-ylmethyl)-2-(pyridin-4-yl)furan-3-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::BMCL184373 Compound 17::SB-699393 Serine/threonine-protein kinase B-raf Homo sapiens 7.2 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.070 10.7270/Q26D5R86 18621524 aid1798626 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26056&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91593400 56464493 ZINC13974295 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46350 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) YZDJQTHVDDOVHR-UHFFFAOYSA-N 25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720 Serine/threonine-protein kinase B-raf Homo sapiens 160 7 22.00 C Curated from the literature by BindingDB 10.1073/pnas.0711741105 10.7270/Q2SB441T 18287029 aid1798569 Tsai, J; Lee, JT; Wang, W; Zhang, J; Cho, H; Mamo, S; Bremer, R; Gillette, S; Kong, J; Haass, NK; Sproesser, K; Li, L; Smalley, KS; Fong, D; Zhu, YL; Marimuthu, A; Nguyen, H; Lam, B; Liu, J; Cheung, I; Rice, J; Suzuki, Y; Luu, C; Settachatgul, C; Shellooe, R; Cantwell, J; Kim, SH; Schlessinger, J; Zhang, KY; West, BL; Powell, B; Habets, G; Zhang, C; Ibrahim, PN; Hirth, P; Artis, DR; Herlyn, M; Bollag, G Plexxikon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25617&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 324 3C4C,4WO5 24180719 56412907 DB06999 5703 ZINC39059267 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46362 O=NC1CCc2cc(ccc12)-c1c[nH]nc1-c1ccncc1 InChI=1S/C17H14N4O/c22-21-16-4-2-12-9-13(1-3-14(12)16)15-10-19-20-17(15)11-5-7-18-8-6-11/h1,3,5-10,16H,2,4H2,(H,19,20) QXXGBIGYGBFXEV-UHFFFAOYSA-N 25618 (1Z)-5-[3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole-based inhibitor, 1 Serine/threonine-protein kinase B-raf Homo sapiens 0.15 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25618&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91051236 56412908 ZINC40979960 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46363 Cn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C18H16N4O/c1-22-11-16(18(20-22)12-6-8-19-9-7-12)14-2-4-15-13(10-14)3-5-17(15)21-23/h2,4,6-11,17H,3,5H2,1H3 YHYOXKSUCQMRRA-UHFFFAOYSA-N 25619 (1Z)-5-[1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole-based inhibitor, 2a Serine/threonine-protein kinase B-raf Homo sapiens 0.02 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25619&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896020 56412909 ZINC35941254 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46364 Cn1ncc(c1-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C18H16N4O/c1-22-18(12-6-8-19-9-7-12)16(11-20-22)14-2-4-15-13(10-14)3-5-17(15)21-23/h2,4,6-11,17H,3,5H2,1H3 QUVQCDXLKWRQAX-UHFFFAOYSA-N 25620 (1Z)-5-[1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole-based inhibitor, 2b Serine/threonine-protein kinase B-raf Homo sapiens 0.48 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25620&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90967078 56412910 ZINC40424213 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46365 CCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C19H18N4O/c1-2-23-12-17(19(21-23)13-7-9-20-10-8-13)15-3-5-16-14(11-15)4-6-18(16)22-24/h3,5,7-12,18H,2,4,6H2,1H3 RHZAYSYBOMRKAJ-UHFFFAOYSA-N 25621 (1Z)-5-[1-ethyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole-based inhibitor, 3 Serine/threonine-protein kinase B-raf Homo sapiens 0.57 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25621&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896021 56412911 ZINC40425447 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46366 O=NC1CCc2cc(ccc12)-c1cn(nc1-c1ccncc1)C1CCCC1 InChI=1S/C22H22N4O/c27-25-21-8-6-16-13-17(5-7-19(16)21)20-14-26(18-3-1-2-4-18)24-22(20)15-9-11-23-12-10-15/h5,7,9-14,18,21H,1-4,6,8H2 KLVLOCJNJSWYTC-UHFFFAOYSA-N 25622 (1Z)-5-[1-cyclopentyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole-based inhibitor, 4 Serine/threonine-protein kinase B-raf Homo sapiens 3.46 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25622&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896022 56412912 ZINC40425164 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46367 O[C@H]1CCC[C@H]1n1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C22H22N4O2/c27-21-3-1-2-20(21)26-13-18(22(24-26)14-8-10-23-11-9-14)16-4-6-17-15(12-16)5-7-19(17)25-28/h4,6,8-13,19-21,27H,1-3,5,7H2/t19?,20-,21+/m1/s1 KWDGJDFHCLCZOX-JUODMZLFSA-N 25623 (1S,2R)-2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}cyclopentan-1-ol::pyrazole-based inhibitor, 5 Serine/threonine-protein kinase B-raf Homo sapiens 3.91 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25623&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896023 56412913 ZINC62154056 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46368 O[C@@H]1CCC[C@H]1n1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C22H22N4O2/c27-21-3-1-2-20(21)26-13-18(22(24-26)14-8-10-23-11-9-14)16-4-6-17-15(12-16)5-7-19(17)25-28/h4,6,8-13,19-21,27H,1-3,5,7H2/t19?,20-,21-/m1/s1 KWDGJDFHCLCZOX-RWLBOTFQSA-N 25624 (1R,2R)-2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}cyclopentan-1-ol::pyrazole-based inhibitor, 6 Serine/threonine-protein kinase B-raf Homo sapiens 0.33 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25624&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896024 56412914 ZINC62154057 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46369 O[C@H]1CCC[C@H](C1)n1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C23H24N4O2/c28-19-3-1-2-18(13-19)27-14-21(23(25-27)15-8-10-24-11-9-15)17-4-6-20-16(12-17)5-7-22(20)26-29/h4,6,8-12,14,18-19,22,28H,1-3,5,7,13H2/t18-,19+,22?/m1/s1 PYDZXHXSHZEHQG-DKPCLATOSA-N 25625 (1S,3R)-3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}cyclohexan-1-ol::pyrazole-based inhibitor, 7 Serine/threonine-protein kinase B-raf Homo sapiens 0.04 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25625&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896025 56412915 ZINC40430336 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46370 O[C@@H]1CCC[C@H](C1)n1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C23H24N4O2/c28-19-3-1-2-18(13-19)27-14-21(23(25-27)15-8-10-24-11-9-15)17-4-6-20-16(12-17)5-7-22(20)26-29/h4,6,8-12,14,18-19,22,28H,1-3,5,7,13H2/t18-,19-,22?/m1/s1 PYDZXHXSHZEHQG-IERKJGKXSA-N 25626 (1R,3R)-3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}cyclohexan-1-ol::pyrazole-based inhibitor, 8 Serine/threonine-protein kinase B-raf Homo sapiens 0.09 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25626&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896026 56412916 ZINC40974273 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46371 COCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C20H20N4O2/c1-26-11-10-24-13-18(20(22-24)14-6-8-21-9-7-14)16-2-4-17-15(12-16)3-5-19(17)23-25/h2,4,6-9,12-13,19H,3,5,10-11H2,1H3 LWGIVTHVQPXLQY-UHFFFAOYSA-N 25627 (1Z)-5-[1-(2-methoxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole-based inhibitor, 9 Serine/threonine-protein kinase B-raf Homo sapiens 1.16 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25627&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896027 56412917 ZINC40424153 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46372 OCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,18,24H,2,4,9-10H2 RIGIGAFKKVBACY-UHFFFAOYSA-N 25628 2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethan-1-ol::AR00341677::CHEMBL525191::GDC-0879 Serine/threonine-protein kinase B-raf Homo sapiens 0.13 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25628&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91448975 56412918 CHEMBL525191 ZINC34640412 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46373 OCCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C20H20N4O2/c25-11-1-10-24-13-18(20(22-24)14-6-8-21-9-7-14)16-2-4-17-15(12-16)3-5-19(17)23-26/h2,4,6-9,12-13,19,25H,1,3,5,10-11H2 KGRIQNZEDBESQH-UHFFFAOYSA-N 25629 3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}propan-1-ol::pyrazole-based inhibitor, 11 Serine/threonine-protein kinase B-raf Homo sapiens 0.05 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25629&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896028 56412919 ZINC40975515 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46374 OCC(O)Cn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C20H20N4O3/c25-12-16(26)10-24-11-18(20(22-24)13-5-7-21-8-6-13)15-1-3-17-14(9-15)2-4-19(17)23-27/h1,3,5-9,11,16,19,25-26H,2,4,10,12H2 CRTJFFQEWFIJPJ-UHFFFAOYSA-N 25630 3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}propane-1,2-diol::pyrazole based inhibitor, 12 Serine/threonine-protein kinase B-raf Homo sapiens 0.87 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25630&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896029 56412920 ZINC35825799 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46375 OCC(CO)n1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C20H20N4O3/c25-11-16(12-26)24-10-18(20(22-24)13-5-7-21-8-6-13)15-1-3-17-14(9-15)2-4-19(17)23-27/h1,3,5-10,16,19,25-26H,2,4,11-12H2 HVPGJUNTQVBAGO-UHFFFAOYSA-N 25631 2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}propane-1,3-diol::pyrazole based inhibitor, 13 Serine/threonine-protein kinase B-raf Homo sapiens 0.56 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25631&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896030 56412921 ZINC40975796 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46376 NCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C19H19N5O/c20-7-10-24-12-17(19(22-24)13-5-8-21-9-6-13)15-1-3-16-14(11-15)2-4-18(16)23-25/h1,3,5-6,8-9,11-12,18H,2,4,7,10,20H2 FJZWVBAFEWPCOV-UHFFFAOYSA-N 25632 2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethan-1-amine::pyrazole based inhibitor, 14 Serine/threonine-protein kinase B-raf Homo sapiens 2.4 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25632&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896031 56412922 ZINC38214267 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46377 CN(C)CCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C21H23N5O/c1-25(2)11-12-26-14-19(21(23-26)15-7-9-22-10-8-15)17-3-5-18-16(13-17)4-6-20(18)24-27/h3,5,7-10,13-14,20H,4,6,11-12H2,1-2H3 WBAXPGYKKFBTLR-UHFFFAOYSA-N 25633 (2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethyl)dimethylamine::pyrazole based inhibitor, 15 Serine/threonine-protein kinase B-raf Homo sapiens 4.02 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25633&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896032 56412923 ZINC40425407 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46378 NCCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C20H21N5O/c21-8-1-11-25-13-18(20(23-25)14-6-9-22-10-7-14)16-2-4-17-15(12-16)3-5-19(17)24-26/h2,4,6-7,9-10,12-13,19H,1,3,5,8,11,21H2 QEGWQNKUFAZZCG-UHFFFAOYSA-N 25634 3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}propan-1-amine::pyrazole based inhibitor, 16 Serine/threonine-protein kinase B-raf Homo sapiens 0.39 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25634&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896033 56412924 ZINC38208516 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46379 CN(C)CCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C22H25N5O/c1-26(2)12-3-13-27-15-20(22(24-27)16-8-10-23-11-9-16)18-4-6-19-17(14-18)5-7-21(19)25-28/h4,6,8-11,14-15,21H,3,5,7,12-13H2,1-2H3 YNOFAPGWJZOOII-UHFFFAOYSA-N 25635 (3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}propyl)dimethylamine::pyrazole based inhibitor, 17 Serine/threonine-protein kinase B-raf Homo sapiens 0.47 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25635&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896034 56412925 ZINC40429730 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46380 O=NC1CCc2cc(ccc12)-c1cn(nc1-c1ccncc1)C1CCNCC1 InChI=1S/C22H23N5O/c28-26-21-4-2-16-13-17(1-3-19(16)21)20-14-27(18-7-11-24-12-8-18)25-22(20)15-5-9-23-10-6-15/h1,3,5-6,9-10,13-14,18,21,24H,2,4,7-8,11-12H2 RCDPVKCEMFLESQ-UHFFFAOYSA-N 25636 (1Z)-5-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole based inhibitor, 18 Serine/threonine-protein kinase B-raf Homo sapiens 0.03 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25636&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896035 56412926 ZINC39110119 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46381 CN1CCC(CC1)n1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C23H25N5O/c1-27-12-8-19(9-13-27)28-15-21(23(25-28)16-6-10-24-11-7-16)18-2-4-20-17(14-18)3-5-22(20)26-29/h2,4,6-7,10-11,14-15,19,22H,3,5,8-9,12-13H2,1H3 DJXMCIWYEITNAK-UHFFFAOYSA-N 25637 (1Z)-5-[1-(1-methylpiperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole based inhibitor, 19 Serine/threonine-protein kinase B-raf Homo sapiens 0.34 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25637&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896036 56412927 ZINC35983365 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46382 O=NC1CCc2cc(ccc12)-c1cn(nc1-c1ccncc1)C1CCOCC1 InChI=1S/C22H22N4O2/c27-25-21-4-2-16-13-17(1-3-19(16)21)20-14-26(18-7-11-28-12-8-18)24-22(20)15-5-9-23-10-6-15/h1,3,5-6,9-10,13-14,18,21H,2,4,7-8,11-12H2 JURIKYZJJRIJAH-UHFFFAOYSA-N 25638 (1Z)-5-[1-(oxan-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole based inhibitor, 20 Serine/threonine-protein kinase B-raf Homo sapiens 0.22 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25638&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896037 56412928 ZINC35950597 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46383 O=NC1CCc2cc(ccc12)-c1cn(CC2CCNCC2)nc1-c1ccncc1 InChI=1S/C23H25N5O/c29-27-22-4-2-18-13-19(1-3-20(18)22)21-15-28(14-16-5-9-24-10-6-16)26-23(21)17-7-11-25-12-8-17/h1,3,7-8,11-13,15-16,22,24H,2,4-6,9-10,14H2 XGNQOONJLJPCDZ-UHFFFAOYSA-N 25639 (1Z)-5-[1-(piperidin-4-ylmethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole based inhibitor, 21 Serine/threonine-protein kinase B-raf Homo sapiens 1.2 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25639&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896038 56412929 ZINC35931977 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46384 O=NC1CCc2cc(ccc12)-c1cn(CC2CCCNC2)nc1-c1ccncc1 InChI=1S/C23H25N5O/c29-27-22-6-4-18-12-19(3-5-20(18)22)21-15-28(14-16-2-1-9-25-13-16)26-23(21)17-7-10-24-11-8-17/h3,5,7-8,10-12,15-16,22,25H,1-2,4,6,9,13-14H2 YLWQVOLMOFXGGH-UHFFFAOYSA-N 25640 (1Z)-5-[1-(piperidin-3-ylmethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole-based inhibitor, 22 Serine/threonine-protein kinase B-raf Homo sapiens 0.85 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25640&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896039 56412930 ZINC40425228 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46385 CNC1CCCC(C1)n1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C24H27N5O/c1-25-19-3-2-4-20(14-19)29-15-22(24(27-29)16-9-11-26-12-10-16)18-5-7-21-17(13-18)6-8-23(21)28-30/h5,7,9-13,15,19-20,23,25H,2-4,6,8,14H2,1H3 NNFRBCFFCSKCFE-UHFFFAOYSA-N 25641 3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}-N-methylcyclohexan-1-amine::pyrazole-based inhibitor, 23 Serine/threonine-protein kinase B-raf Homo sapiens 0.23 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25641&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896040 56412931 ZINC40973962 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46386 Cn1cc(c(n1)-c1ccc2n(C)ncc2c1)-c1ccc2C(CCc2c1)N=O InChI=1S/C21H19N5O/c1-25-12-18(14-3-6-17-13(9-14)4-7-19(17)24-27)21(23-25)15-5-8-20-16(10-15)11-22-26(20)2/h3,5-6,8-12,19H,4,7H2,1-2H3 DXWKANKMOAIVKQ-UHFFFAOYSA-N 25642 (1Z)-5-[1-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole-based inhibitor, 24 Serine/threonine-protein kinase B-raf Homo sapiens 969.6 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25642&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896041 56412932 ZINC40974202 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46387 Cn1cc(c(n1)-c1cccnc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C18H16N4O/c1-22-11-16(18(20-22)14-3-2-8-19-10-14)13-4-6-15-12(9-13)5-7-17(15)21-23/h2-4,6,8-11,17H,5,7H2,1H3 HVQGSGICKXGJFU-UHFFFAOYSA-N 25643 (1Z)-5-[1-methyl-3-(pyridin-3-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole-based inhibitor, 25 Serine/threonine-protein kinase B-raf Homo sapiens 433.8 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25643&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896042 56412933 ZINC40974799 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46388 Cn1cc(c(n1)-c1cnco1)-c1ccc2C(CCc2c1)N=O InChI=1S/C16H14N4O2/c1-20-8-13(16(18-20)15-7-17-9-22-15)11-2-4-12-10(6-11)3-5-14(12)19-21/h2,4,6-9,14H,3,5H2,1H3 ZLUOUODRGRXXJG-UHFFFAOYSA-N 25644 (1Z)-5-[1-methyl-3-(1,3-oxazol-5-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole-based inhibitor, 26 Serine/threonine-protein kinase B-raf Homo sapiens 4.1 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25644&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896043 56412934 ZINC40974801 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46389 Cn1cc(c(n1)-c1ccnc(N)c1)-c1ccc2C(CCc2c1)N=O InChI=1S/C18H17N5O/c1-23-10-15(18(21-23)13-6-7-20-17(19)9-13)12-2-4-14-11(8-12)3-5-16(14)22-24/h2,4,6-10,16H,3,5H2,1H3,(H2,19,20) NSOGUEGPCSDLSD-UHFFFAOYSA-N 25645 4-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-1-methyl-1H-pyrazol-3-yl}pyridin-2-amine::pyrazole-based inhibitor, 27 Serine/threonine-protein kinase B-raf Homo sapiens 2.1 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25645&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896044 56412935 ZINC40425242 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46390 Cn1cc(c(n1)-c1ccncc1O)-c1ccc2C(CCc2c1)N=O InChI=1S/C18H16N4O2/c1-22-10-15(18(20-22)14-6-7-19-9-17(14)23)12-2-4-13-11(8-12)3-5-16(13)21-24/h2,4,6-10,16,23H,3,5H2,1H3 KLWOACDZIMMYOP-UHFFFAOYSA-N 25646 4-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-1-methyl-1H-pyrazol-3-yl}pyridin-3-ol::pyrazole-based inhibitor, 28 Serine/threonine-protein kinase B-raf Homo sapiens 2.9 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25646&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896045 56412936 ZINC62154058 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46391 Cn1cc(c(n1)-c1ccncn1)-c1ccc2C(CCc2c1)N=O InChI=1S/C17H15N5O/c1-22-9-14(17(20-22)16-6-7-18-10-19-16)12-2-4-13-11(8-12)3-5-15(13)21-23/h2,4,6-10,15H,3,5H2,1H3 QZKJNLHNTUOKIK-UHFFFAOYSA-N 25647 (1Z)-5-[1-methyl-3-(pyrimidin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole-based inhibitor, 29 Serine/threonine-protein kinase B-raf Homo sapiens 3.1 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25647&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91896046 56412937 ZINC40429142 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46392 Cn1cc(c(n1)-c1ccncc1)-c1ccc(cc1)C(=N)NO InChI=1S/C16H15N5O/c1-21-10-14(15(19-21)12-6-8-18-9-7-12)11-2-4-13(5-3-11)16(17)20-22/h2-10,22H,1H3,(H2,17,20) QYBPQELFZBKETA-UHFFFAOYSA-N 25648 N'-hydroxy-4-[1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]benzene-1-carboximidamide::pyrazole-based inhibitor, 30 Serine/threonine-protein kinase B-raf Homo sapiens 18.4 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25648&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25093323 56412938 ZINC40431373 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46393 Cn1cc(c(n1)-c1ccncc1)-c1ccc2C(NO)=NCc2c1 InChI=1S/C17H15N5O/c1-22-10-15(16(20-22)11-4-6-18-7-5-11)12-2-3-14-13(8-12)9-19-17(14)21-23/h2-8,10,23H,9H2,1H3,(H,19,21) RXOAUTDNEHGRQR-UHFFFAOYSA-N 25649 (1E)-5-[1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-isoindole-1-hydroxylamine::pyrazole-based inhibitor, 31 Serine/threonine-protein kinase B-raf Homo sapiens <2 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25649&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11500476 56412939 ZINC40974450 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46394 Cn1cc(c(n1)-c1ccncc1)-c1ccc2C(NO)=NCCc2c1 InChI=1S/C18H17N5O/c1-23-11-16(17(21-23)12-4-7-19-8-5-12)13-2-3-15-14(10-13)6-9-20-18(15)22-24/h2-5,7-8,10-11,24H,6,9H2,1H3,(H,20,22) OHZUFQGNOLPVKE-UHFFFAOYSA-N 25650 (1E)-6-[1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroisoquinoline-1-hydroxylamine::pyrazole-based inhibitor, 32 Serine/threonine-protein kinase B-raf Homo sapiens 16.0 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25650&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11681274 56412940 ZINC40974452 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46395 Cn1cc(c(n1)-c1ccncc1)-c1ccc(cc1)-c1cc[nH]n1 InChI=1S/C18H15N5/c1-23-12-16(18(22-23)15-6-9-19-10-7-15)13-2-4-14(5-3-13)17-8-11-20-21-17/h2-12H,1H3,(H,20,21) ZZGACVWRPAHSSW-UHFFFAOYSA-N 25651 4-{1-methyl-4-[4-(1H-pyrazol-3-yl)phenyl]-1H-pyrazol-3-yl}pyridine::pyrazole based inhibitor, 33 Serine/threonine-protein kinase B-raf Homo sapiens 68.4 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25651&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25093324 56412941 ZINC40424253 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46396 Cc1c[nH]nc1-c1ccc(cc1)-c1cn(C)nc1-c1ccncc1 InChI=1S/C19H17N5/c1-13-11-21-22-18(13)15-5-3-14(4-6-15)17-12-24(2)23-19(17)16-7-9-20-10-8-16/h3-12H,1-2H3,(H,21,22) ITRATIKKSKBADF-UHFFFAOYSA-N 25652 4-{1-methyl-4-[4-(4-methyl-1H-pyrazol-3-yl)phenyl]-1H-pyrazol-3-yl}pyridine::pyrazole based inhibitor, 34 Serine/threonine-protein kinase B-raf Homo sapiens 4.4 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25652&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25093325 56412942 ZINC40974702 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46397 Cn1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C19H15N5/c1-24-11-17(19(23-24)12-4-6-20-7-5-12)13-2-3-16-14(8-13)9-15-10-21-22-18(15)16/h2-8,10-11H,9H2,1H3,(H,21,22) MAOYHJWWEYWDEQ-UHFFFAOYSA-N 25653 4-(4-{2H,4H-indeno[1,2-c]pyrazol-6-yl}-1-methyl-1H-pyrazol-3-yl)pyridine::pyrazole-based inhibitor, 35 Serine/threonine-protein kinase B-raf Homo sapiens 1.5 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25653&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25093326 56412943 ZINC40973541 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46398 Cn1cc(c(n1)-c1ccncc1)-c1ccc2C(=O)NCc2c1 InChI=1S/C17H14N4O/c1-21-10-15(16(20-21)11-4-6-18-7-5-11)12-2-3-14-13(8-12)9-19-17(14)22/h2-8,10H,9H2,1H3,(H,19,22) FLQRRMNRUINMJD-UHFFFAOYSA-N 25654 5-[1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-isoindol-1-one::pyrazole based inhibitor, 36 Serine/threonine-protein kinase B-raf Homo sapiens 68.4 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25654&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25093327 56412944 ZINC62154059 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 46399 Cn1cc(c(n1)-c1ccncc1)-c1ccc2cn[nH]c2c1 InChI=1S/C16H13N5/c1-21-10-14(16(20-21)11-4-6-17-7-5-11)12-2-3-13-9-18-19-15(13)8-12/h2-10H,1H3,(H,18,19) RGCICAWWIIRITL-UHFFFAOYSA-N 25655 6-[1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-1H-indazole::pyrazole based inhibitor, 37 Serine/threonine-protein kinase B-raf Homo sapiens 70.0 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.07.002 10.7270/Q2NK3CBJ 18676143 aid1798572 Hansen, JD; Grina, J; Newhouse, B; Welch, M; Topalov, G; Littman, N; Callejo, M; Gloor, S; Martinson, M; Laird, E; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25655&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25093328 56412945 ZINC40424822 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65335 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Serine/threonine-protein kinase B-raf Homo sapiens 630 PubChem 10.7270/Q2ZK5F2B aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65336 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Serine/threonine-protein kinase B-raf Homo sapiens 1700 PubChem 10.7270/Q2ZK5F2B aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65337 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Serine/threonine-protein kinase B-raf Homo sapiens 2700 PubChem 10.7270/Q2ZK5F2B aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65338 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Serine/threonine-protein kinase B-raf Homo sapiens 1200 PubChem 10.7270/Q2ZK5F2B aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65339 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Serine/threonine-protein kinase B-raf Homo sapiens 500 PubChem 10.7270/Q2ZK5F2B aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65340 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Serine/threonine-protein kinase B-raf Homo sapiens 730 PubChem 10.7270/Q2ZK5F2B aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65341 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Serine/threonine-protein kinase B-raf Homo sapiens 2900 PubChem 10.7270/Q2ZK5F2B aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65342 Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) QHKYPYXTTXKZST-UHFFFAOYSA-N 13531 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190 Serine/threonine-protein kinase B-raf Homo sapiens 4800 PubChem 10.7270/Q2ZK5F2B aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13531&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 5353940 172097219 ZINC14951176 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65343 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Serine/threonine-protein kinase B-raf Homo sapiens 710 PubChem 10.7270/Q2ZK5F2B aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65344 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 540 PubChem 10.7270/Q2ZK5F2B aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65345 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Serine/threonine-protein kinase B-raf Homo sapiens 280 PubChem 10.7270/Q2TX3CQG aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65346 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Serine/threonine-protein kinase B-raf Homo sapiens 130 PubChem 10.7270/Q2TX3CQG aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65347 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Serine/threonine-protein kinase B-raf Homo sapiens 330 PubChem 10.7270/Q2TX3CQG aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65348 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Serine/threonine-protein kinase B-raf Homo sapiens 570 PubChem 10.7270/Q2TX3CQG aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65349 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Serine/threonine-protein kinase B-raf Homo sapiens 430 PubChem 10.7270/Q2TX3CQG aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65350 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Serine/threonine-protein kinase B-raf Homo sapiens 3300 PubChem 10.7270/Q2TX3CQG aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65351 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Serine/threonine-protein kinase B-raf Homo sapiens 2300 PubChem 10.7270/Q2TX3CQG aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65352 Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) QHKYPYXTTXKZST-UHFFFAOYSA-N 13531 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190 Serine/threonine-protein kinase B-raf Homo sapiens 620 PubChem 10.7270/Q2TX3CQG aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13531&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 5353940 172097219 ZINC14951176 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65353 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Serine/threonine-protein kinase B-raf Homo sapiens 530 PubChem 10.7270/Q2TX3CQG aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 65354 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 260 PubChem 10.7270/Q2TX3CQG aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 227545 Cc1nc(Cl)cc(Nc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2)n1 InChI=1S/C19H14Cl2F3N5O/c1-10-25-16(21)9-17(26-10)27-11-3-2-4-12(7-11)28-18(30)29-13-5-6-15(20)14(8-13)19(22,23)24/h2-9H,1H3,(H,25,26,27)(H2,28,29,30) OQNAEPJXWHOMFY-UHFFFAOYSA-N 107673 1-(3-(6-Chloro-2-methylpyrimidin-4-ylamino)phenyl)- 3-(4-chloro-3-(trifluoromethyl)phenyl)urea (Compound 1) Serine/threonine-protein kinase B-raf Homo sapiens 722 7.5 25.00 C Curated from the literature by BindingDB 10.1111/cbdd.12198 10.7270/Q2VH5MHM 24164966 aid1800189 Zhang, Q; Wang, J; Wang, F; Chen, X; He, Y; You, Q; Zhou, H Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70674520 186524543 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 227546 Cc1nc(Nc2cccc(NC(=O)Nc3ccc(F)c(Cl)c3)c2)cc(n1)N1CCOCC1 InChI=1S/C22H22ClFN6O2/c1-14-25-20(13-21(26-14)30-7-9-32-10-8-30)27-15-3-2-4-16(11-15)28-22(31)29-17-5-6-19(24)18(23)12-17/h2-6,11-13H,7-10H2,1H3,(H,25,26,27)(H2,28,29,31) AQMQQBLCOUAJDA-UHFFFAOYSA-N 107674 1-(3-Chloro-4-fluorophenyl)-3-(3-(2-methyl- 6-morpholinopyrimidin-4-ylamino)phenyl)urea (Compound 2) Serine/threonine-protein kinase B-raf Homo sapiens 1068 7.5 25.00 C Curated from the literature by BindingDB 10.1111/cbdd.12198 10.7270/Q2VH5MHM 24164966 aid1800189 Zhang, Q; Wang, J; Wang, F; Chen, X; He, Y; You, Q; Zhou, H Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107674&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70674635 186524544 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 227547 Cc1nc(Nc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2)cc(n1)N1CCOCC1 InChI=1S/C23H22ClF3N6O2/c1-14-28-20(13-21(29-14)33-7-9-35-10-8-33)30-15-3-2-4-16(11-15)31-22(34)32-17-5-6-19(24)18(12-17)23(25,26)27/h2-6,11-13H,7-10H2,1H3,(H,28,29,30)(H2,31,32,34) FOKJZPXZXWUIQD-UHFFFAOYSA-N 107675 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(2- methyl-6-morpholinopyrimidin-4-ylamino)phenyl) urea (Compound 3) Serine/threonine-protein kinase B-raf Homo sapiens 271 7.5 25.00 C Curated from the literature by BindingDB 10.1111/cbdd.12198 10.7270/Q2VH5MHM 24164966 aid1800189 Zhang, Q; Wang, J; Wang, F; Chen, X; He, Y; You, Q; Zhou, H Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107675&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70674636 186524545 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 227548 CN1CCN(CC1)c1cc(Nc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2)nc(C)n1 InChI=1S/C24H25ClF3N7O/c1-15-29-21(14-22(30-15)35-10-8-34(2)9-11-35)31-16-4-3-5-17(12-16)32-23(36)33-18-6-7-20(25)19(13-18)24(26,27)28/h3-7,12-14H,8-11H2,1-2H3,(H,29,30,31)(H2,32,33,36) ITLPVLLAPQMEHN-UHFFFAOYSA-N 107676 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(2- methyl-6-(4-methylpiperazin-1-yl)pyrimidin- 4-ylamino)phenyl)urea (Compound 4) Serine/threonine-protein kinase B-raf Homo sapiens >10000 7.5 25.00 C Curated from the literature by BindingDB 10.1111/cbdd.12198 10.7270/Q2VH5MHM 24164966 aid1800189 Zhang, Q; Wang, J; Wang, F; Chen, X; He, Y; You, Q; Zhou, H Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107676&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70674989 186524546 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 227549 CN(c1cccc(NC(=O)Nc2ccc(F)c(Cl)c2)c1)c1cc(nc(C)n1)N1CCOCC1 InChI=1S/C23H24ClFN6O2/c1-15-26-21(14-22(27-15)31-8-10-33-11-9-31)30(2)18-5-3-4-16(12-18)28-23(32)29-17-6-7-20(25)19(24)13-17/h3-7,12-14H,8-11H2,1-2H3,(H2,28,29,32) RXDXXZIPMNRAIO-UHFFFAOYSA-N 107677 1-(3-Chloro-4-fluorophenyl)-3-(3-(methyl (2-methyl-6-morpholinopyrimidin-4-yl)amino) phenyl)urea (Compound 5) Serine/threonine-protein kinase B-raf Homo sapiens 366 7.5 25.00 C Curated from the literature by BindingDB 10.1111/cbdd.12198 10.7270/Q2VH5MHM 24164966 aid1800189 Zhang, Q; Wang, J; Wang, F; Chen, X; He, Y; You, Q; Zhou, H Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107677&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70675106 186524547 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 227550 CN(c1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1)c1cc(nc(C)n1)N1CCOCC1 InChI=1S/C24H24ClF3N6O2/c1-15-29-21(14-22(30-15)34-8-10-36-11-9-34)33(2)18-5-3-4-16(12-18)31-23(35)32-17-6-7-20(25)19(13-17)24(26,27)28/h3-7,12-14H,8-11H2,1-2H3,(H2,31,32,35) KEPZHZCLLGEQSX-UHFFFAOYSA-N 107678 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(methyl (2-methyl-6-morpholinopyrimidin-4-yl)amino) phenyl)urea (Compound 6) Serine/threonine-protein kinase B-raf Homo sapiens 1370 7.5 25.00 C Curated from the literature by BindingDB 10.1111/cbdd.12198 10.7270/Q2VH5MHM 24164966 aid1800189 Zhang, Q; Wang, J; Wang, F; Chen, X; He, Y; You, Q; Zhou, H Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107678&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70675217 186524548 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 227551 CN(c1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1)c1cc(nc(C)n1)N1CCN(C)CC1 InChI=1S/C25H27ClF3N7O/c1-16-30-22(15-23(31-16)36-11-9-34(2)10-12-36)35(3)19-6-4-5-17(13-19)32-24(37)33-18-7-8-21(26)20(14-18)25(27,28)29/h4-8,13-15H,9-12H2,1-3H3,(H2,32,33,37) GGLLNLSQMVWDML-UHFFFAOYSA-N 107679 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(methyl (2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl) amino)phenyl)urea (Compound 7) Serine/threonine-protein kinase B-raf Homo sapiens 5280 7.5 25.00 C Curated from the literature by BindingDB 10.1111/cbdd.12198 10.7270/Q2VH5MHM 24164966 aid1800189 Zhang, Q; Wang, J; Wang, F; Chen, X; He, Y; You, Q; Zhou, H Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107679&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70675477 186524549 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 227552 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 114 7.5 25.00 C Curated from the literature by BindingDB 10.1111/cbdd.12198 10.7270/Q2VH5MHM 24164966 aid1800189 Zhang, Q; Wang, J; Wang, F; Chen, X; He, Y; You, Q; Zhou, H Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 254306 CCN1CCN(Cc2ccc(NC(=O)c3cccc(c3)-c3ccc4nc(NC(=O)C5CC5)sc4n3)cc2C(F)(F)F)CC1 InChI=1S/C29H25F3N8OS/c1-17-34-24(16-25(35-17)40-12-10-33-11-13-40)39-28-38-23-9-8-22(37-27(23)42-28)18-4-2-5-19(14-18)26(41)36-21-7-3-6-20(15-21)29(30,31)32/h2-9,14-16,33H,10-13H2,1H3,(H,36,41)(H,34,35,38,39) LQPZDDNAQNTKSD-UHFFFAOYSA-N 124970 US8765747, 2 Serine/threonine-protein kinase B-raf Homo sapiens 36 US Patent 10.7270/Q2VX0F6R aid1800532 US8765747 Choi, HG; Sim, T; Gray, N; Zhou, W; Chang, JW; Zhang, J; Weisberg, E Dana-Farber Cancer Institute Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124970&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search NG7 4AGW 51359962 225151358 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256975 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccccc3)c2c1 InChI=1S/C21H17N3O2/c1-26-20-12-15(8-10-19(20)25)14-7-9-18-17(11-14)21(23-13-22-18)24-16-5-3-2-4-6-16/h2-13,25H,1H3,(H,22,23,24) ZYIVFBQMIVATBO-UHFFFAOYSA-N 126926 US8785459, 1 Serine/threonine-protein kinase B-raf Homo sapiens 900 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126926&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610727 225153273 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256976 COc1cccc(c1)-c1ccc2ncnc(Nc3ccccc3)c2c1 InChI=1S/C21H17N3O/c1-25-18-9-5-6-15(12-18)16-10-11-20-19(13-16)21(23-14-22-20)24-17-7-3-2-4-8-17/h2-14H,1H3,(H,22,23,24) KMACGYJVKXHEGA-UHFFFAOYSA-N 126928 US8785459, 3 Serine/threonine-protein kinase B-raf Homo sapiens 3292 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126928&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 3234753 225153275 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256977 Oc1ccc(cc1)-c1ccc2ncnc(Nc3ccccc3)c2c1 InChI=1S/C20H15N3O/c24-17-9-6-14(7-10-17)15-8-11-19-18(12-15)20(22-13-21-19)23-16-4-2-1-3-5-16/h1-13,24H,(H,21,22,23) PEIOQGQNZUURLI-UHFFFAOYSA-N 126929 US8785459, 4 Serine/threonine-protein kinase B-raf Homo sapiens 3986 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126929&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611810 225153276 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256978 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc(O)c3)c2c1 InChI=1S/C21H17N3O3/c1-27-20-10-14(6-8-19(20)26)13-5-7-18-17(9-13)21(23-12-22-18)24-15-3-2-4-16(25)11-15/h2-12,25-26H,1H3,(H,22,23,24) LXUOHVWXSIYKFA-UHFFFAOYSA-N 126933 US8785459, 8 Serine/threonine-protein kinase B-raf Homo sapiens 30.2 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126933&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612079 225153280 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256979 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc(F)c(Cl)c3)c2c1 InChI=1S/C21H15ClFN3O2/c1-28-20-9-13(3-7-19(20)27)12-2-6-18-15(8-12)21(25-11-24-18)26-14-4-5-17(23)16(22)10-14/h2-11,27H,1H3,(H,24,25,26) GCIMOXRJCCJFHE-UHFFFAOYSA-N 126939 US8785459, 14 Serine/threonine-protein kinase B-raf Homo sapiens 1014 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126939&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611948 225153286 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256980 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc(F)cc3)c2c1 InChI=1S/C21H16FN3O2/c1-27-20-11-14(3-9-19(20)26)13-2-8-18-17(10-13)21(24-12-23-18)25-16-6-4-15(22)5-7-16/h2-12,26H,1H3,(H,23,24,25) UXJNJXDYBPWNOB-UHFFFAOYSA-N 126940 US8785459, 15 Serine/threonine-protein kinase B-raf Homo sapiens 1154 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126940&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611807 225153287 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256981 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc(Cl)cc3F)c2c1 InChI=1S/C21H15ClFN3O2/c1-28-20-9-13(3-7-19(20)27)12-2-5-17-15(8-12)21(25-11-24-17)26-18-6-4-14(22)10-16(18)23/h2-11,27H,1H3,(H,24,25,26) YNUOKJQLMFJASA-UHFFFAOYSA-N 126941 US8785459, 16 Serine/threonine-protein kinase B-raf Homo sapiens 817.2 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126941&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611670 225153288 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256982 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc(C)cc3F)c2c1 InChI=1S/C22H18FN3O2/c1-13-3-6-19(17(23)9-13)26-22-16-10-14(4-7-18(16)24-12-25-22)15-5-8-20(27)21(11-15)28-2/h3-12,27H,1-2H3,(H,24,25,26) CNDJHJOZDIWJPS-UHFFFAOYSA-N 126942 US8785459, 17 Serine/threonine-protein kinase B-raf Homo sapiens 647.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126942&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611812 225153289 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256983 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc(c3)C(F)(F)F)c2c1 InChI=1S/C22H16F3N3O2/c1-30-20-10-14(6-8-19(20)29)13-5-7-18-17(9-13)21(27-12-26-18)28-16-4-2-3-15(11-16)22(23,24)25/h2-12,29H,1H3,(H,26,27,28) QSRJUWTVHOQBPZ-UHFFFAOYSA-N 126943 US8785459, 18 Serine/threonine-protein kinase B-raf Homo sapiens 3136 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126943&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611668 225153290 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256984 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc(O)cc3)c2c1 InChI=1S/C21H17N3O3/c1-27-20-11-14(3-9-19(20)26)13-2-8-18-17(10-13)21(23-12-22-18)24-15-4-6-16(25)7-5-15/h2-12,25-26H,1H3,(H,22,23,24) YVGALQKPXFBOSA-UHFFFAOYSA-N 126944 US8785459, 19 Serine/threonine-protein kinase B-raf Homo sapiens 557 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126944&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611669 225153291 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256985 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc(F)cc3F)c2c1 InChI=1S/C21H15F2N3O2/c1-28-20-9-13(3-7-19(20)27)12-2-5-17-15(8-12)21(25-11-24-17)26-18-6-4-14(22)10-16(18)23/h2-11,27H,1H3,(H,24,25,26) YUERBQPSJHOKJZ-UHFFFAOYSA-N 126945 US8785459, 20 Serine/threonine-protein kinase B-raf Homo sapiens 593.7 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126945&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611808 225153292 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256986 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc(Cl)cc3O)c2c1 InChI=1S/C21H16ClN3O3/c1-28-20-9-13(3-7-18(20)26)12-2-5-16-15(8-12)21(24-11-23-16)25-17-6-4-14(22)10-19(17)27/h2-11,26-27H,1H3,(H,23,24,25) YITYQFMKMIKUEV-UHFFFAOYSA-N 126946 US8785459, 21 Serine/threonine-protein kinase B-raf Homo sapiens 1125 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126946&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611667 225153293 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256987 COc1cccc(Nc2ncnc3ccc(cc23)-c2ccc(O)c(OC)c2)c1 InChI=1S/C22H19N3O3/c1-27-17-5-3-4-16(12-17)25-22-18-10-14(6-8-19(18)23-13-24-22)15-7-9-20(26)21(11-15)28-2/h3-13,26H,1-2H3,(H,23,24,25) SEOLDYFMKMKGLS-UHFFFAOYSA-N 126947 US8785459, 22 Serine/threonine-protein kinase B-raf Homo sapiens 719 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126947&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611666 225153294 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256988 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccccc3O)c2c1 InChI=1S/C21H17N3O3/c1-27-20-11-14(7-9-19(20)26)13-6-8-16-15(10-13)21(23-12-22-16)24-17-4-2-3-5-18(17)25/h2-12,25-26H,1H3,(H,22,23,24) AOGQDMUHHOXPLR-UHFFFAOYSA-N 126948 US8785459, 23 Serine/threonine-protein kinase B-raf Homo sapiens 669 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126948&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766626 225153295 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256989 CCS(=O)(=O)Nc1ccc(cc1)-c1ccc2ncnc(Nc3ccccc3)c2c1 InChI=1S/C22H20N4O2S/c1-2-29(27,28)26-19-11-8-16(9-12-19)17-10-13-21-20(14-17)22(24-15-23-21)25-18-6-4-3-5-7-18/h3-15,26H,2H2,1H3,(H,23,24,25) JGLUULOHSRDUND-UHFFFAOYSA-N 126949 US8785459, 24 Serine/threonine-protein kinase B-raf Homo sapiens 1695 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126949&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611665 225153296 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256990 COc1ccc(Nc2ncnc3ccc(cc23)-c2ccc(O)c(OC)c2)cc1O InChI=1S/C22H19N3O4/c1-28-20-8-5-15(11-19(20)27)25-22-16-9-13(3-6-17(16)23-12-24-22)14-4-7-18(26)21(10-14)29-2/h3-12,26-27H,1-2H3,(H,23,24,25) OUZLTSCGCAFBAX-UHFFFAOYSA-N 126950 US8785459, 25 Serine/threonine-protein kinase B-raf Homo sapiens 1106 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126950&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766627 225153297 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256991 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc(c3)S(N)(=O)=O)c2c1 InChI=1S/C21H18N4O4S/c1-29-20-10-14(6-8-19(20)26)13-5-7-18-17(9-13)21(24-12-23-18)25-15-3-2-4-16(11-15)30(22,27)28/h2-12,26H,1H3,(H2,22,27,28)(H,23,24,25) CTDIPKVKSWWUCY-UHFFFAOYSA-N 126952 US8785459, 27 Serine/threonine-protein kinase B-raf Homo sapiens 415 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126952&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611523 225153299 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256992 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc(C)c(O)c3)c2c1 InChI=1S/C22H19N3O3/c1-13-3-6-16(11-20(13)27)25-22-17-9-14(4-7-18(17)23-12-24-22)15-5-8-19(26)21(10-15)28-2/h3-12,26-27H,1-2H3,(H,23,24,25) YQPMOXSWJBWGTI-UHFFFAOYSA-N 126954 US8785459, 29 Serine/threonine-protein kinase B-raf Homo sapiens 177 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126954&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611524 225153301 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256993 COc1cc(ccc1O)-c1cc2c(Nc3cccc(O)c3)ncnc2cc1OC InChI=1S/C22H19N3O4/c1-28-20-11-18-17(10-16(20)13-6-7-19(27)21(8-13)29-2)22(24-12-23-18)25-14-4-3-5-15(26)9-14/h3-12,26-27H,1-2H3,(H,23,24,25) RQPRRMWEMYPJCU-UHFFFAOYSA-N 126956 US8785459, 31 Serine/threonine-protein kinase B-raf Homo sapiens 87 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126956&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611390 225153303 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256994 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccccc3C(N)=O)c2c1 InChI=1S/C22H18N4O3/c1-29-20-11-14(7-9-19(20)27)13-6-8-17-16(10-13)22(25-12-24-17)26-18-5-3-2-4-15(18)21(23)28/h2-12,27H,1H3,(H2,23,28)(H,24,25,26) LBMAYKRTTSORJV-UHFFFAOYSA-N 126958 US8785459, 33 Serine/threonine-protein kinase B-raf Homo sapiens 666.8 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126958&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611520 225153305 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256995 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc(cc3O)C(O)=O)c2c1 InChI=1S/C22H17N3O5/c1-30-20-10-13(4-7-18(20)26)12-2-5-16-15(8-12)21(24-11-23-16)25-17-6-3-14(22(28)29)9-19(17)27/h2-11,26-27H,1H3,(H,28,29)(H,23,24,25) REWNVEJKEAUCTR-UHFFFAOYSA-N 126959 US8785459, 34 Serine/threonine-protein kinase B-raf Homo sapiens 494.2 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126959&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611389 225153306 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256996 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc(c3)C(N)=O)c2c1 InChI=1S/C22H18N4O3/c1-29-20-11-14(6-8-19(20)27)13-5-7-18-17(10-13)22(25-12-24-18)26-16-4-2-3-15(9-16)21(23)28/h2-12,27H,1H3,(H2,23,28)(H,24,25,26) RTOHFILATZRMIA-UHFFFAOYSA-N 126960 US8785459, 35 Serine/threonine-protein kinase B-raf Homo sapiens 317.4 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126960&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611251 225153307 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256997 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc(c3)[N+]([O-])=O)c2c1 InChI=1S/C21H16N4O4/c1-29-20-10-14(6-8-19(20)26)13-5-7-18-17(9-13)21(23-12-22-18)24-15-3-2-4-16(11-15)25(27)28/h2-12,26H,1H3,(H,22,23,24) BVLCRQIUDNYCEV-UHFFFAOYSA-N 126961 US8785459, 36 Serine/threonine-protein kinase B-raf Homo sapiens 255.7 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126961&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611388 225153308 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256998 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc(N)c3)c2c1 InChI=1S/C21H18N4O2/c1-27-20-10-14(6-8-19(20)26)13-5-7-18-17(9-13)21(24-12-23-18)25-16-4-2-3-15(22)11-16/h2-12,26H,22H2,1H3,(H,23,24,25) PXEGMZUZLILJBF-UHFFFAOYSA-N 126962 US8785459, 37 Serine/threonine-protein kinase B-raf Homo sapiens 572.8 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126962&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611386 225153309 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 256999 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc4OCOc4c3)c2c1 InChI=1S/C22H17N3O4/c1-27-20-9-14(3-6-18(20)26)13-2-5-17-16(8-13)22(24-11-23-17)25-15-4-7-19-21(10-15)29-12-28-19/h2-11,26H,12H2,1H3,(H,23,24,25) CDDJPUXBKKUCDP-UHFFFAOYSA-N 126963 US8785459, 38 Serine/threonine-protein kinase B-raf Homo sapiens 659.5 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126963&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766628 225153310 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257000 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc4cn[nH]c4c3)c2c1 InChI=1S/C22H17N5O2/c1-29-21-9-14(4-7-20(21)28)13-3-6-18-17(8-13)22(24-12-23-18)26-16-5-2-15-11-25-27-19(15)10-16/h2-12,28H,1H3,(H,25,27)(H,23,24,26) DODAIJUIZVYMOG-UHFFFAOYSA-N 126964 US8785459, 39 Serine/threonine-protein kinase B-raf Homo sapiens 1030 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126964&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611387 225153311 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257001 COc1cc(ccc1O)-c1cc2c(Nc3ccc(C)c(O)c3)ncnc2cc1OC InChI=1S/C23H21N3O4/c1-13-4-6-15(9-20(13)28)26-23-17-10-16(14-5-7-19(27)22(8-14)30-3)21(29-2)11-18(17)24-12-25-23/h4-12,27-28H,1-3H3,(H,24,25,26) IWLOLULNROCYDO-UHFFFAOYSA-N 126966 US8785459, 41 Serine/threonine-protein kinase B-raf Homo sapiens 266.5 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126966&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611249 225153313 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257002 COc1cc(ccc1O)-c1cc2c(Nc3cc(O)ccc3Cl)ncnc2cc1OC InChI=1S/C22H18ClN3O4/c1-29-20-10-17-15(9-14(20)12-3-6-19(28)21(7-12)30-2)22(25-11-24-17)26-18-8-13(27)4-5-16(18)23/h3-11,27-28H,1-2H3,(H,24,25,26) JKTUMOGNOXQHCW-UHFFFAOYSA-N 126968 US8785459, 43 Serine/threonine-protein kinase B-raf Homo sapiens 40.4 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126968&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611106 225153315 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257003 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc(NC(C)=O)c3)c2c1 InChI=1S/C23H20N4O3/c1-14(28)26-17-4-3-5-18(12-17)27-23-19-10-15(6-8-20(19)24-13-25-23)16-7-9-21(29)22(11-16)30-2/h3-13,29H,1-2H3,(H,26,28)(H,24,25,27) VUYNPJZLYCLBTQ-UHFFFAOYSA-N 126969 US8785459, 44 Serine/threonine-protein kinase B-raf Homo sapiens 489 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126969&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611247 225153316 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257004 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc(NC(=O)C(F)(F)F)c3)c2c1 InChI=1S/C23H17F3N4O3/c1-33-20-10-14(6-8-19(20)31)13-5-7-18-17(9-13)21(28-12-27-18)29-15-3-2-4-16(11-15)30-22(32)23(24,25)26/h2-12,31H,1H3,(H,30,32)(H,27,28,29) ZGKQLQVUCURDPT-UHFFFAOYSA-N 126970 US8785459, 45 Serine/threonine-protein kinase B-raf Homo sapiens 381.6 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126970&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611246 225153317 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257005 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc(cc3)S(N)(=O)=O)c2c1 InChI=1S/C21H18N4O4S/c1-29-20-11-14(3-9-19(20)26)13-2-8-18-17(10-13)21(24-12-23-18)25-15-4-6-16(7-5-15)30(22,27)28/h2-12,26H,1H3,(H2,22,27,28)(H,23,24,25) JTVVBVDAHYWCNK-UHFFFAOYSA-N 126971 US8785459, 46 Serine/threonine-protein kinase B-raf Homo sapiens 623.7 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126971&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611103 225153318 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257006 COc1cc2ncnc(Nc3cccc(O)c3)c2cc1-c1ccc(O)cc1 InChI=1S/C21H17N3O3/c1-27-20-11-19-18(10-17(20)13-5-7-15(25)8-6-13)21(23-12-22-19)24-14-3-2-4-16(26)9-14/h2-12,25-26H,1H3,(H,22,23,24) IDLIZJWWQMZOEP-UHFFFAOYSA-N 126974 US8785459, 49 Serine/threonine-protein kinase B-raf Homo sapiens 55.3 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126974&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766630 225153321 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257007 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H17N5O2/c1-29-21-10-14(6-8-20(21)28)13-5-7-17-15(9-13)22(24-12-23-17)26-18-3-2-4-19-16(18)11-25-27-19/h2-12,28H,1H3,(H,25,27)(H,23,24,26) DMGHIXCKZCVUCS-UHFFFAOYSA-N 126976 US8785459, 51 Serine/threonine-protein kinase B-raf Homo sapiens 121.3 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126976&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610851 225153323 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257008 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc(F)c3)c2c1 InChI=1S/C21H16FN3O2/c1-27-20-10-14(6-8-19(20)26)13-5-7-18-17(9-13)21(24-12-23-18)25-16-4-2-3-15(22)11-16/h2-12,26H,1H3,(H,23,24,25) HUXUXLDHERERSY-UHFFFAOYSA-N 126977 US8785459, 52 Serine/threonine-protein kinase B-raf Homo sapiens 560.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126977&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610974 225153324 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257009 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc(O)c3C)c2c1 InChI=1S/C22H19N3O3/c1-13-17(4-3-5-19(13)26)25-22-16-10-14(6-8-18(16)23-12-24-22)15-7-9-20(27)21(11-15)28-2/h3-12,26-27H,1-2H3,(H,23,24,25) YUKMSXPRELDPTH-UHFFFAOYSA-N 126978 US8785459, 53 Serine/threonine-protein kinase B-raf Homo sapiens 141.4 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126978&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766631 225153325 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257010 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc4nc[nH]c4c3)c2c1 InChI=1S/C22H17N5O2/c1-29-21-9-14(3-7-20(21)28)13-2-5-17-16(8-13)22(26-12-23-17)27-15-4-6-18-19(10-15)25-11-24-18/h2-12,28H,1H3,(H,24,25)(H,23,26,27) AHVVSCJYHRESQX-UHFFFAOYSA-N 126979 US8785459, 54 Serine/threonine-protein kinase B-raf Homo sapiens 735.2 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126979&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610852 225153326 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257011 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc(NS(C)(=O)=O)c3)c2c1 InChI=1S/C22H20N4O4S/c1-30-21-11-15(7-9-20(21)27)14-6-8-19-18(10-14)22(24-13-23-19)25-16-4-3-5-17(12-16)26-31(2,28)29/h3-13,26-27H,1-2H3,(H,23,24,25) YMLDRYXNSGMREG-UHFFFAOYSA-N 126981 US8785459, 56 Serine/threonine-protein kinase B-raf Homo sapiens 462.6 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126981&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610972 225153328 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257012 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cc(O)ccc3F)c2c1 InChI=1S/C21H16FN3O3/c1-28-20-9-13(3-7-19(20)27)12-2-6-17-15(8-12)21(24-11-23-17)25-18-10-14(26)4-5-16(18)22/h2-11,26-27H,1H3,(H,23,24,25) GQDIEXXTSJEMLK-UHFFFAOYSA-N 126983 US8785459, 58 Serine/threonine-protein kinase B-raf Homo sapiens 16.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126983&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71598728 225153330 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257013 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cc(O)ccc3Cl)c2c1 InChI=1S/C21H16ClN3O3/c1-28-20-9-13(3-7-19(20)27)12-2-6-17-15(8-12)21(24-11-23-17)25-18-10-14(26)4-5-16(18)22/h2-11,26-27H,1H3,(H,23,24,25) QUJBTURDNRPSNX-UHFFFAOYSA-N 126984 US8785459, 59 Serine/threonine-protein kinase B-raf Homo sapiens 36.5 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126984&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611102 225153331 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257014 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc(O)c3Cl)c2c1 InChI=1S/C21H16ClN3O3/c1-28-19-10-13(6-8-17(19)26)12-5-7-15-14(9-12)21(24-11-23-15)25-16-3-2-4-18(27)20(16)22/h2-11,26-27H,1H3,(H,23,24,25) IYQPENHNLZPWEI-UHFFFAOYSA-N 126985 US8785459, 60 Serine/threonine-protein kinase B-raf Homo sapiens 39 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126985&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766632 225153332 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257015 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cc(O)c(Cl)cc3Cl)c2c1 InChI=1S/C21H15Cl2N3O3/c1-29-20-7-12(3-5-18(20)27)11-2-4-16-13(6-11)21(25-10-24-16)26-17-9-19(28)15(23)8-14(17)22/h2-10,27-28H,1H3,(H,24,25,26) JZPICOLPXYYVOK-UHFFFAOYSA-N 126986 US8785459, 61 Serine/threonine-protein kinase B-raf Homo sapiens 40.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126986&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612578 225153333 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257016 Oc1ccc(cc1)-c1ccc2ncnc(Nc3cccc(O)c3)c2c1 InChI=1S/C20H15N3O2/c24-16-7-4-13(5-8-16)14-6-9-19-18(10-14)20(22-12-21-19)23-15-2-1-3-17(25)11-15/h1-12,24-25H,(H,21,22,23) FXYFPGHBBFPMEI-UHFFFAOYSA-N 126987 US8785459, 62 Serine/threonine-protein kinase B-raf Homo sapiens 32.5 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126987&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610585 225153334 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257017 Oc1cccc(Nc2ncnc3ccc(cc23)-c2cccc(O)c2)c1 InChI=1S/C20H15N3O2/c24-16-5-1-3-13(9-16)14-7-8-19-18(10-14)20(22-12-21-19)23-15-4-2-6-17(25)11-15/h1-12,24-25H,(H,21,22,23) JLJIZMYJZWBZBY-UHFFFAOYSA-N 126988 US8785459, 63 Serine/threonine-protein kinase B-raf Homo sapiens 27.7 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126988&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71611101 225153335 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257018 COc1ccc(cc1)-c1ccc2ncnc(Nc3cccc(O)c3)c2c1 InChI=1S/C21H17N3O2/c1-26-18-8-5-14(6-9-18)15-7-10-20-19(11-15)21(23-13-22-20)24-16-3-2-4-17(25)12-16/h2-13,25H,1H3,(H,22,23,24) YOVFBIUTXSMTJA-UHFFFAOYSA-N 126989 US8785459, 64 Serine/threonine-protein kinase B-raf Homo sapiens 62.4 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126989&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610977 225153336 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257019 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc4nn[nH]c4c3)c2c1 InChI=1S/C21H17N6O2/c1-29-20-9-13(3-7-19(20)28)12-2-5-16-15(8-12)21(23-11-22-16)24-14-4-6-17-18(10-14)26-27-25-17/h2-11,25,28H,1H3,(H,26,27)(H,22,23,24) OGTIYAKSYPEGGO-UHFFFAOYSA-N 126991 US8785459, 66 Serine/threonine-protein kinase B-raf Homo sapiens 1011 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126991&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766633 225153338 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257020 COc1cccc(c1)-c1ccc2ncnc(Nc3cccc(O)c3)c2c1 InChI=1S/C21H17N3O2/c1-26-18-7-2-4-14(10-18)15-8-9-20-19(11-15)21(23-13-22-20)24-16-5-3-6-17(25)12-16/h2-13,25H,1H3,(H,22,23,24) HZZXLHGMSBSXLD-UHFFFAOYSA-N 126992 US8785459, 67 Serine/threonine-protein kinase B-raf Homo sapiens 102.6 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126992&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612579 225153339 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257021 COc1cc2ncnc(Nc3cccc(O)c3)c2cc1-c1ccc(N)cc1 InChI=1S/C21H18N4O2/c1-27-20-11-19-18(10-17(20)13-5-7-14(22)8-6-13)21(24-12-23-19)25-15-3-2-4-16(26)9-15/h2-12,26H,22H2,1H3,(H,23,24,25) PLMGQLOWNWVITJ-UHFFFAOYSA-N 126993 US8785459, 68 Serine/threonine-protein kinase B-raf Homo sapiens 55.8 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126993&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612575 225153340 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257022 Nc1ccc(cc1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C21H16N6/c22-15-7-4-13(5-8-15)14-6-9-18-16(10-14)21(24-12-23-18)26-19-2-1-3-20-17(19)11-25-27-20/h1-12H,22H2,(H,25,27)(H,23,24,26) PSTHQEKRNOGKMV-UHFFFAOYSA-N 126994 US8785459, 69 Serine/threonine-protein kinase B-raf Homo sapiens 259.8 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126994&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612576 225153341 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257023 CC(=O)Nc1ccc(cc1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H18N6O/c1-14(30)27-17-8-5-15(6-9-17)16-7-10-20-18(11-16)23(25-13-24-20)28-21-3-2-4-22-19(21)12-26-29-22/h2-13H,1H3,(H,26,29)(H,27,30)(H,24,25,28) OJHKFJUSIRGQQQ-UHFFFAOYSA-N 126996 US8785459, 71 Serine/threonine-protein kinase B-raf Homo sapiens 373 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126996&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612452 225153343 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257024 CS(=O)(=O)Nc1cccc(c1)-c1ccc2ncnc(Nc3cccc(O)c3)c2c1 InChI=1S/C21H18N4O3S/c1-29(27,28)25-17-6-2-4-14(10-17)15-8-9-20-19(11-15)21(23-13-22-20)24-16-5-3-7-18(26)12-16/h2-13,25-26H,1H3,(H,22,23,24) LIUVILQGTPHLCP-UHFFFAOYSA-N 126997 US8785459, 72 Serine/threonine-protein kinase B-raf Homo sapiens 73.8 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126997&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612454 225153344 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257025 CS(=O)(=O)Nc1ccc(cc1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H18N6O2S/c1-31(29,30)28-16-8-5-14(6-9-16)15-7-10-19-17(11-15)22(24-13-23-19)26-20-3-2-4-21-18(20)12-25-27-21/h2-13,28H,1H3,(H,25,27)(H,23,24,26) AIRBIJZQXTYQEK-UHFFFAOYSA-N 126998 US8785459, 73 Serine/threonine-protein kinase B-raf Homo sapiens 366.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126998&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612453 225153345 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257026 COc1cccc(-c2ccc3ncnc(Nc4cccc5[nH]ncc45)c3c2)c1F InChI=1S/C22H16FN5O/c1-29-20-7-2-4-14(21(20)23)13-8-9-17-15(10-13)22(25-12-24-17)27-18-5-3-6-19-16(18)11-26-28-19/h2-12H,1H3,(H,26,28)(H,24,25,27) IXIUVUHHQIIALQ-UHFFFAOYSA-N 126999 US8785459, 74 Serine/threonine-protein kinase B-raf Homo sapiens 113.8 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126999&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612451 225153346 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257027 COc1ccc(cc1F)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H16FN5O/c1-29-21-8-6-14(10-17(21)23)13-5-7-18-15(9-13)22(25-12-24-18)27-19-3-2-4-20-16(19)11-26-28-20/h2-12H,1H3,(H,26,28)(H,24,25,27) DKBXZWNDVYAPOD-UHFFFAOYSA-N 127000 US8785459, 75 Serine/threonine-protein kinase B-raf Homo sapiens 156.9 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127000&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612450 225153347 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257028 COc1ccc(cc1Cl)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H16ClN5O/c1-29-21-8-6-14(10-17(21)23)13-5-7-18-15(9-13)22(25-12-24-18)27-19-3-2-4-20-16(19)11-26-28-20/h2-12H,1H3,(H,26,28)(H,24,25,27) FWEFVGNOSVSIJW-UHFFFAOYSA-N 127001 US8785459, 76 Serine/threonine-protein kinase B-raf Homo sapiens 215.7 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127001&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612449 225153348 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257029 COc1ccc(c(C)c1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H19N5O/c1-14-10-16(29-2)7-8-17(14)15-6-9-20-18(11-15)23(25-13-24-20)27-21-4-3-5-22-19(21)12-26-28-22/h3-13H,1-2H3,(H,26,28)(H,24,25,27) JQVUJRFPCRJONE-UHFFFAOYSA-N 127002 US8785459, 77 Serine/threonine-protein kinase B-raf Homo sapiens 697.7 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127002&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612331 225153349 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257030 COc1ccc(cc1C)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H19N5O/c1-14-10-15(7-9-22(14)29-2)16-6-8-19-17(11-16)23(25-13-24-19)27-20-4-3-5-21-18(20)12-26-28-21/h3-13H,1-2H3,(H,26,28)(H,24,25,27) SUBFNUBHERPQJA-UHFFFAOYSA-N 127003 US8785459, 78 Serine/threonine-protein kinase B-raf Homo sapiens 470.4 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127003&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612333 225153350 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257031 Fc1ccc(cc1Cl)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C21H13ClFN5/c22-16-9-13(4-6-17(16)23)12-5-7-18-14(8-12)21(25-11-24-18)27-19-2-1-3-20-15(19)10-26-28-20/h1-11H,(H,26,28)(H,24,25,27) QIPIVWOFVWLIOY-UHFFFAOYSA-N 127004 US8785459, 79 Serine/threonine-protein kinase B-raf Homo sapiens 513.6 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127004&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612332 225153351 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257032 Clc1ccc(cc1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C21H14ClN5/c22-15-7-4-13(5-8-15)14-6-9-18-16(10-14)21(24-12-23-18)26-19-2-1-3-20-17(19)11-25-27-20/h1-12H,(H,25,27)(H,23,24,26) UPEJCLCLSGLFGB-UHFFFAOYSA-N 127005 US8785459, 80 Serine/threonine-protein kinase B-raf Homo sapiens 286.8 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127005&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612205 225153352 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257033 Fc1cccc(c1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C21H14FN5/c22-15-4-1-3-13(9-15)14-7-8-18-16(10-14)21(24-12-23-18)26-19-5-2-6-20-17(19)11-25-27-20/h1-12H,(H,25,27)(H,23,24,26) NRQIJWIEEFFCNG-UHFFFAOYSA-N 127006 US8785459, 81 Serine/threonine-protein kinase B-raf Homo sapiens 244 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127006&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612330 225153353 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257034 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc4nn[nH]c34)c2c1 InChI=1S/C21H16N6O2/c1-29-19-10-13(6-8-18(19)28)12-5-7-15-14(9-12)21(23-11-22-15)24-16-3-2-4-17-20(16)26-27-25-17/h2-11,28H,1H3,(H,22,23,24)(H,25,26,27) RBUGHHDIROAPEP-UHFFFAOYSA-N 127007 US8785459, 82 Serine/threonine-protein kinase B-raf Homo sapiens 668.2 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127007&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766634 225153354 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257035 COc1cc(ccc1F)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H16FN5O/c1-29-21-10-14(5-7-17(21)23)13-6-8-18-15(9-13)22(25-12-24-18)27-19-3-2-4-20-16(19)11-26-28-20/h2-12H,1H3,(H,26,28)(H,24,25,27) GSSNIHZZGNIKKX-UHFFFAOYSA-N 127009 US8785459, 84 Serine/threonine-protein kinase B-raf Homo sapiens 171.8 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127009&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612204 225153356 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257036 Fc1ccc(cc1F)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C21H13F2N5/c22-16-6-4-13(9-17(16)23)12-5-7-18-14(8-12)21(25-11-24-18)27-19-2-1-3-20-15(19)10-26-28-20/h1-11H,(H,26,28)(H,24,25,27) XPLFQVYYHOHJKT-UHFFFAOYSA-N 127010 US8785459, 85 Serine/threonine-protein kinase B-raf Homo sapiens 173.9 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127010&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766635 225153357 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257037 N(c1cccc2[nH]ncc12)c1ncnc2ccc(cc12)-c1ccccc1 InChI=1S/C21H15N5/c1-2-5-14(6-3-1)15-9-10-18-16(11-15)21(23-13-22-18)25-19-7-4-8-20-17(19)12-24-26-20/h1-13H,(H,24,26)(H,22,23,25) FPWUSMQPGFKDHT-UHFFFAOYSA-N 127011 US8785459, 86 Serine/threonine-protein kinase B-raf Homo sapiens 201.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127011&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612084 225153358 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257038 FC(F)(F)c1cccc(c1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H14F3N5/c23-22(24,25)15-4-1-3-13(9-15)14-7-8-18-16(10-14)21(27-12-26-18)29-19-5-2-6-20-17(19)11-28-30-20/h1-12H,(H,28,30)(H,26,27,29) GKJKOLGGHMKEKH-UHFFFAOYSA-N 127012 US8785459, 87 Serine/threonine-protein kinase B-raf Homo sapiens 356.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127012&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612083 225153359 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257039 [C-]#[N+]c1ccc(cc1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H14N6/c1-23-16-8-5-14(6-9-16)15-7-10-19-17(11-15)22(25-13-24-19)27-20-3-2-4-21-18(20)12-26-28-21/h2-13H,(H,26,28)(H,24,25,27) VGECRUXSXMDLST-UHFFFAOYSA-N 127013 US8785459, 88 Serine/threonine-protein kinase B-raf Homo sapiens 248.9 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127013&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766636 225153360 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257040 COc1ccc(cc1OC)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H19N5O2/c1-29-21-9-7-15(11-22(21)30-2)14-6-8-18-16(10-14)23(25-13-24-18)27-19-4-3-5-20-17(19)12-26-28-20/h3-13H,1-2H3,(H,26,28)(H,24,25,27) LPFGHVPGOMOXRL-UHFFFAOYSA-N 127014 US8785459, 89 Serine/threonine-protein kinase B-raf Homo sapiens 205 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127014&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612202 225153361 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257041 CN(C)c1ccc(cc1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H20N6/c1-29(2)17-9-6-15(7-10-17)16-8-11-20-18(12-16)23(25-14-24-20)27-21-4-3-5-22-19(21)13-26-28-22/h3-14H,1-2H3,(H,26,28)(H,24,25,27) ARIIUWLBERKDFF-UHFFFAOYSA-N 127015 US8785459, 90 Serine/threonine-protein kinase B-raf Homo sapiens 762.5 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127015&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612082 225153362 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257042 Fc1ccccc1-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C21H14FN5/c22-17-5-2-1-4-14(17)13-8-9-18-15(10-13)21(24-12-23-18)26-19-6-3-7-20-16(19)11-25-27-20/h1-12H,(H,25,27)(H,23,24,26) RRTHRSWEVXNJAZ-UHFFFAOYSA-N 127016 US8785459, 91 Serine/threonine-protein kinase B-raf Homo sapiens 154.9 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127016&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612203 225153363 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257043 [O-][N+](=O)c1cccc(c1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C21H14N6O2/c28-27(29)15-4-1-3-13(9-15)14-7-8-18-16(10-14)21(23-12-22-18)25-19-5-2-6-20-17(19)11-24-26-20/h1-12H,(H,24,26)(H,22,23,25) GBOCYHNQTLBNDS-UHFFFAOYSA-N 127017 US8785459, 92 Serine/threonine-protein kinase B-raf Homo sapiens 428.3 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127017&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612201 225153364 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257044 CCOc1ccc(cc1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H19N5O/c1-2-29-17-9-6-15(7-10-17)16-8-11-20-18(12-16)23(25-14-24-20)27-21-4-3-5-22-19(21)13-26-28-22/h3-14H,2H2,1H3,(H,26,28)(H,24,25,27) JTUOQTSUUNRMJL-UHFFFAOYSA-N 127018 US8785459, 93 Serine/threonine-protein kinase B-raf Homo sapiens 346.8 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127018&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612080 225153365 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257045 OCc1cccc(c1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H17N5O/c28-12-14-3-1-4-15(9-14)16-7-8-19-17(10-16)22(24-13-23-19)26-20-5-2-6-21-18(20)11-25-27-21/h1-11,13,28H,12H2,(H,25,27)(H,23,24,26) OZNYKUWGKVIPAK-UHFFFAOYSA-N 127019 US8785459, 94 Serine/threonine-protein kinase B-raf Homo sapiens 430 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127019&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71612081 225153366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257046 CS(=O)(=O)Nc1cccc(c1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H18N6O2S/c1-31(29,30)28-16-5-2-4-14(10-16)15-8-9-19-17(11-15)22(24-13-23-19)26-20-6-3-7-21-18(20)12-25-27-21/h2-13,28H,1H3,(H,25,27)(H,23,24,26) XSUHCAXBYNKVRB-UHFFFAOYSA-N 127020 US8785459, 95 Serine/threonine-protein kinase B-raf Homo sapiens 430 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127020&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766637 225153367 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257047 C1Oc2ccc(cc2O1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H15N5O2/c1-2-18(16-10-25-27-19(16)3-1)26-22-15-8-13(4-6-17(15)23-11-24-22)14-5-7-20-21(9-14)29-12-28-20/h1-11H,12H2,(H,25,27)(H,23,24,26) XWIWBSJSAJBMPD-UHFFFAOYSA-N 127021 US8785459, 96 Serine/threonine-protein kinase B-raf Homo sapiens 141.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127021&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766638 225153368 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257048 NC(=O)c1cccc(c1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H16N6O/c23-21(29)15-4-1-3-13(9-15)14-7-8-18-16(10-14)22(25-12-24-18)27-19-5-2-6-20-17(19)11-26-28-20/h1-12H,(H2,23,29)(H,26,28)(H,24,25,27) MLIUWSBFWSVRQG-UHFFFAOYSA-N 127022 US8785459, 97 Serine/threonine-protein kinase B-raf Homo sapiens 112 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127022&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610848 225153369 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257049 COc1ccc(cc1C=O)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H17N5O2/c1-30-22-8-6-14(9-16(22)12-29)15-5-7-19-17(10-15)23(25-13-24-19)27-20-3-2-4-21-18(20)11-26-28-21/h2-13H,1H3,(H,26,28)(H,24,25,27) VFBQPPQDEDDLEP-UHFFFAOYSA-N 127023 US8785459, 98 Serine/threonine-protein kinase B-raf Homo sapiens 73.9 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127023&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766639 225153370 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257050 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc4n(C)ncc34)c2c1 InChI=1S/C23H19N5O2/c1-28-20-5-3-4-19(17(20)12-26-28)27-23-16-10-14(6-8-18(16)24-13-25-23)15-7-9-21(29)22(11-15)30-2/h3-13,29H,1-2H3,(H,24,25,27) LNNUOBRPBFYIDV-UHFFFAOYSA-N 127024 US8785459, 99 Serine/threonine-protein kinase B-raf Homo sapiens 357.9 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127024&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610725 225153371 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257051 COc1cc(ccc1O)-c1ccc2nccc(Nc3cccc(O)c3)c2c1 InChI=1S/C22H18N2O3/c1-27-22-12-15(6-8-21(22)26)14-5-7-19-18(11-14)20(9-10-23-19)24-16-3-2-4-17(25)13-16/h2-13,25-26H,1H3,(H,23,24) FPLRMYGGQYVCJG-UHFFFAOYSA-N 127025 US8785459, 100 Serine/threonine-protein kinase B-raf Homo sapiens 21 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127025&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610849 225153372 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257052 COc1cc(ccc1O)-c1ccc2nccc(Nc3cc(O)ccc3F)c2c1 InChI=1S/C22H17FN2O3/c1-28-22-11-14(3-7-21(22)27)13-2-6-18-16(10-13)19(8-9-24-18)25-20-12-15(26)4-5-17(20)23/h2-12,26-27H,1H3,(H,24,25) RJXWOJXFFJYMDD-UHFFFAOYSA-N 127026 US8785459, 101 Serine/threonine-protein kinase B-raf Homo sapiens 18.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127026&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766640 225153373 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257053 N#Cc1cccc(c1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H14N6/c23-11-14-3-1-4-15(9-14)16-7-8-19-17(10-16)22(25-13-24-19)27-20-5-2-6-21-18(20)12-26-28-21/h1-10,12-13H,(H,26,28)(H,24,25,27) SFZSBQZXGZGTSA-UHFFFAOYSA-N 127027 US8785459, 102 Serine/threonine-protein kinase B-raf Homo sapiens 134 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127027&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610726 225153374 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257054 COc1cc(ccc1O)-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H18N4O2/c1-29-23-12-15(6-8-22(23)28)14-5-7-18-16(11-14)20(9-10-24-18)26-19-3-2-4-21-17(19)13-25-27-21/h2-13,28H,1H3,(H,24,26)(H,25,27) DRQRHUXWPRBMNP-UHFFFAOYSA-N 127028 US8785459, 103 Serine/threonine-protein kinase B-raf Homo sapiens 164.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127028&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766641 225153375 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257055 Cc1ccc(F)cc1-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H16FN5/c1-13-5-7-15(23)10-16(13)14-6-8-19-17(9-14)22(25-12-24-19)27-20-3-2-4-21-18(20)11-26-28-21/h2-12H,1H3,(H,26,28)(H,24,25,27) ZBZGWPWATXMCSH-UHFFFAOYSA-N 127029 US8785459, 104 Serine/threonine-protein kinase B-raf Homo sapiens 235.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127029&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766642 225153376 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257056 COc1cccc(-c2ccc3ncnc(Nc4cccc5[nH]ncc45)c3c2)c1OC InChI=1S/C23H19N5O2/c1-29-21-8-3-5-15(22(21)30-2)14-9-10-18-16(11-14)23(25-13-24-18)27-19-6-4-7-20-17(19)12-26-28-20/h3-13H,1-2H3,(H,26,28)(H,24,25,27) YFIHHMAQYZRSSI-UHFFFAOYSA-N 127030 US8785459, 105 Serine/threonine-protein kinase B-raf Homo sapiens 379.9 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127030&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610847 225153377 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257057 CN(C)c1ccc(cc1)-c1ccc2ncnc(Nc3cccc(O)c3)c2c1 InChI=1S/C22H20N4O/c1-26(2)18-9-6-15(7-10-18)16-8-11-21-20(12-16)22(24-14-23-21)25-17-4-3-5-19(27)13-17/h3-14,27H,1-2H3,(H,23,24,25) QTSVTHYYVYDIKZ-UHFFFAOYSA-N 127031 US8785459, 106 Serine/threonine-protein kinase B-raf Homo sapiens 272.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127031&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610588 225153378 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257058 O=S(=O)Nc1ccc(cc1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C21H16N6O2S/c28-30(29)27-15-7-4-13(5-8-15)14-6-9-18-16(10-14)21(23-12-22-18)25-19-2-1-3-20-17(19)11-24-26-20/h1-12,30H,(H,24,26)(H,22,23,25)(H,27,28,29) PTBJHZNXVJXIPX-UHFFFAOYSA-N 127032 US8785459, 107 Serine/threonine-protein kinase B-raf Homo sapiens 344.8 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127032&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766643 225153379 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257059 CCS(=O)(=O)Nc1cccc(c1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H20N6O2S/c1-2-32(30,31)29-17-6-3-5-15(11-17)16-9-10-20-18(12-16)23(25-14-24-20)27-21-7-4-8-22-19(21)13-26-28-22/h3-14,29H,2H2,1H3,(H,26,28)(H,24,25,27) RBUXMTQMUHLZQE-UHFFFAOYSA-N 127033 US8785459, 108 Serine/threonine-protein kinase B-raf Homo sapiens 221.3 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127033&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610586 225153380 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257060 CCCS(=O)(=O)Nc1cccc(c1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C24H22N6O2S/c1-2-11-33(31,32)30-18-6-3-5-16(12-18)17-9-10-21-19(13-17)24(26-15-25-21)28-22-7-4-8-23-20(22)14-27-29-23/h3-10,12-15,30H,2,11H2,1H3,(H,27,29)(H,25,26,28) IDDULONPYZTDCI-UHFFFAOYSA-N 127034 US8785459, 109 Serine/threonine-protein kinase B-raf Homo sapiens 125.8 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127034&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610590 225153381 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257061 CS(=O)(=O)c1ccc(cc1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H17N5O2S/c1-30(28,29)16-8-5-14(6-9-16)15-7-10-19-17(11-15)22(24-13-23-19)26-20-3-2-4-21-18(20)12-25-27-21/h2-13H,1H3,(H,25,27)(H,23,24,26) QSCGMEKWMHMVOY-UHFFFAOYSA-N 127035 US8785459, 110 Serine/threonine-protein kinase B-raf Homo sapiens 247.6 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127035&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610589 225153382 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257062 COc1cccc(-c2ccc3nccc(Nc4cccc5[nH]ncc45)c3c2)c1F InChI=1S/C23H17FN4O/c1-29-22-7-2-4-15(23(22)24)14-8-9-18-16(12-14)20(10-11-25-18)27-19-5-3-6-21-17(19)13-26-28-21/h2-13H,1H3,(H,25,27)(H,26,28) QUBZBDCDFOKXJG-UHFFFAOYSA-N 127036 US8785459, 111 Serine/threonine-protein kinase B-raf Homo sapiens 83.4 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127036&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766645 225153383 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257063 COc1ccc(cc1F)-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H17FN4O/c1-29-23-8-6-15(12-18(23)24)14-5-7-19-16(11-14)21(9-10-25-19)27-20-3-2-4-22-17(20)13-26-28-22/h2-13H,1H3,(H,25,27)(H,26,28) JHNFCCKACPKMID-UHFFFAOYSA-N 127037 US8785459, 112 Serine/threonine-protein kinase B-raf Homo sapiens 181.9 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127037&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766646 225153384 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257064 COc1ccc(cc1OC)-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C24H20N4O2/c1-29-23-9-7-16(13-24(23)30-2)15-6-8-19-17(12-15)21(10-11-25-19)27-20-4-3-5-22-18(20)14-26-28-22/h3-14H,1-2H3,(H,25,27)(H,26,28) KQKPLQROQOPNSH-UHFFFAOYSA-N 127038 US8785459, 113 Serine/threonine-protein kinase B-raf Homo sapiens 262.7 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127038&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766647 225153385 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257065 N#Cc1cccc(c1)-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H15N5/c24-13-15-3-1-4-16(11-15)17-7-8-20-18(12-17)22(9-10-25-20)27-21-5-2-6-23-19(21)14-26-28-23/h1-12,14H,(H,25,27)(H,26,28) YMFSRZPLRNPVIN-UHFFFAOYSA-N 127039 US8785459, 114 Serine/threonine-protein kinase B-raf Homo sapiens 99.2 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127039&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766648 225153386 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257066 COc1ccc(cc1Cl)-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H17ClN4O/c1-29-23-8-6-15(12-18(23)24)14-5-7-19-16(11-14)21(9-10-25-19)27-20-3-2-4-22-17(20)13-26-28-22/h2-13H,1H3,(H,25,27)(H,26,28) VGDSJGFEMAXXAB-UHFFFAOYSA-N 127040 US8785459, 115 Serine/threonine-protein kinase B-raf Homo sapiens 266.8 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127040&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766649 225153387 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257067 COc1ccc(cc1C=O)-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C24H18N4O2/c1-30-24-8-6-15(11-17(24)14-29)16-5-7-20-18(12-16)22(9-10-25-20)27-21-3-2-4-23-19(21)13-26-28-23/h2-14H,1H3,(H,25,27)(H,26,28) IKOITRSYZNZHEZ-UHFFFAOYSA-N 127041 US8785459, 116 Serine/threonine-protein kinase B-raf Homo sapiens 99.6 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127041&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766650 225153388 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257068 NC(=O)c1cccc(c1)-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H17N5O/c24-23(29)16-4-1-3-14(11-16)15-7-8-19-17(12-15)21(9-10-25-19)27-20-5-2-6-22-18(20)13-26-28-22/h1-13H,(H2,24,29)(H,25,27)(H,26,28) UVCHZQRHHYMSJH-UHFFFAOYSA-N 127042 US8785459, 117 Serine/threonine-protein kinase B-raf Homo sapiens 107.2 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127042&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766651 225153389 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257069 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc(OC(F)F)c3)c2c1 InChI=1S/C22H17F2N3O3/c1-29-20-10-14(6-8-19(20)28)13-5-7-18-17(9-13)21(26-12-25-18)27-15-3-2-4-16(11-15)30-22(23)24/h2-12,22,28H,1H3,(H,25,26,27) HPMBPVUWGMRNIX-UHFFFAOYSA-N 127043 US8785459, 118 Serine/threonine-protein kinase B-raf Homo sapiens 548.2 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127043&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766652 225153390 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257070 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccccc3F)c2c1 InChI=1S/C21H16FN3O2/c1-27-20-11-14(7-9-19(20)26)13-6-8-17-15(10-13)21(24-12-23-17)25-18-5-3-2-4-16(18)22/h2-12,26H,1H3,(H,23,24,25) UDYJFMPIXFDZRG-UHFFFAOYSA-N 127044 US8785459, 119 Serine/threonine-protein kinase B-raf Homo sapiens 543.2 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127044&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766653 225153391 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257071 CS(=O)(=O)c1ccc(cc1)-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H18N4O2S/c1-30(28,29)17-8-5-15(6-9-17)16-7-10-20-18(13-16)22(11-12-24-20)26-21-3-2-4-23-19(21)14-25-27-23/h2-14H,1H3,(H,24,26)(H,25,27) OCYFPMVYKUWKCZ-UHFFFAOYSA-N 127045 US8785459, 120 Serine/threonine-protein kinase B-raf Homo sapiens 134.3 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127045&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766654 225153392 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257072 Nc1ccc(cc1)-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H17N5/c23-16-7-4-14(5-8-16)15-6-9-19-17(12-15)21(10-11-24-19)26-20-2-1-3-22-18(20)13-25-27-22/h1-13H,23H2,(H,24,26)(H,25,27) RJMLEEWCSBNXDE-UHFFFAOYSA-N 127046 US8785459, 121 Serine/threonine-protein kinase B-raf Homo sapiens 227.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127046&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766655 225153393 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257073 CCCS(=O)(=O)Nc1cccc(c1)-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C25H23N5O2S/c1-2-13-33(31,32)30-19-6-3-5-17(14-19)18-9-10-22-20(15-18)24(11-12-26-22)28-23-7-4-8-25-21(23)16-27-29-25/h3-12,14-16,30H,2,13H2,1H3,(H,26,28)(H,27,29) WKOVQVJMFWLZTC-UHFFFAOYSA-N 127047 US8785459, 122 Serine/threonine-protein kinase B-raf Homo sapiens 258.6 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127047&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766656 225153394 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257074 COc1cccc(c1)-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H18N4O/c1-28-17-5-2-4-15(12-17)16-8-9-20-18(13-16)22(10-11-24-20)26-21-6-3-7-23-19(21)14-25-27-23/h2-14H,1H3,(H,24,26)(H,25,27) IKXJOEAHXPIXTE-UHFFFAOYSA-N 127048 US8785459, 123::US8785459, 146 Serine/threonine-protein kinase B-raf Homo sapiens 231.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127048&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766657 225153395 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257075 Oc1ccc(cc1)-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H16N4O/c27-16-7-4-14(5-8-16)15-6-9-19-17(12-15)21(10-11-23-19)25-20-2-1-3-22-18(20)13-24-26-22/h1-13,27H,(H,23,25)(H,24,26) ASBVUJOUCCSWLW-UHFFFAOYSA-N 127049 US8785459, 124 Serine/threonine-protein kinase B-raf Homo sapiens 187.9 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127049&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766658 225153396 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257076 Fc1ccccc1-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H15FN4/c23-18-5-2-1-4-15(18)14-8-9-19-16(12-14)21(10-11-24-19)26-20-6-3-7-22-17(20)13-25-27-22/h1-13H,(H,24,26)(H,25,27) URJKXHQBSGCFJP-UHFFFAOYSA-N 127050 US8785459, 125 Serine/threonine-protein kinase B-raf Homo sapiens 285.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127050&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766659 225153397 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257077 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc4[nH]nc(Cl)c34)c2c1 InChI=1S/C22H16ClN5O2/c1-30-19-10-13(6-8-18(19)29)12-5-7-15-14(9-12)22(25-11-24-15)26-16-3-2-4-17-20(16)21(23)28-27-17/h2-11,29H,1H3,(H,27,28)(H,24,25,26) OHDXOILNZGUOHL-UHFFFAOYSA-N 127051 US8785459, 126 Serine/threonine-protein kinase B-raf Homo sapiens 141.7 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127051&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766660 225153398 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257078 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cccc4[nH]c(=O)[nH]c34)c2c1 InChI=1S/C22H17N5O3/c1-30-19-10-13(6-8-18(19)28)12-5-7-15-14(9-12)21(24-11-23-15)25-16-3-2-4-17-20(16)27-22(29)26-17/h2-11,28H,1H3,(H,23,24,25)(H2,26,27,29) BRBHDLXJODGTDC-UHFFFAOYSA-N 127052 US8785459, 127 Serine/threonine-protein kinase B-raf Homo sapiens 887.6 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127052&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89645605 225153399 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257079 COc1cc(ccc1O)-c1ccc2nccc(Nc3cc(NS(C)(=O)=O)ccc3F)c2c1 InChI=1S/C23H20FN3O4S/c1-31-23-12-15(4-8-22(23)28)14-3-7-19-17(11-14)20(9-10-25-19)26-21-13-16(5-6-18(21)24)27-32(2,29)30/h3-13,27-28H,1-2H3,(H,25,26) XVGDFOIUIGQAPW-UHFFFAOYSA-N 127053 US8785459, 128 Serine/threonine-protein kinase B-raf Homo sapiens 4134 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127053&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766662 225153400 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257080 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cc(NS(C)(=O)=O)ccc3F)c2c1 InChI=1S/C22H19FN4O4S/c1-31-21-10-14(4-8-20(21)28)13-3-7-18-16(9-13)22(25-12-24-18)26-19-11-15(5-6-17(19)23)27-32(2,29)30/h3-12,27-28H,1-2H3,(H,24,25,26) HENFWIGBMZNXMI-UHFFFAOYSA-N 127054 US8785459, 129 Serine/threonine-protein kinase B-raf Homo sapiens 240.3 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127054&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766663 225153401 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257081 Oc1ccc(cc1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C21H15N5O/c27-15-7-4-13(5-8-15)14-6-9-18-16(10-14)21(23-12-22-18)25-19-2-1-3-20-17(19)11-24-26-20/h1-12,27H,(H,24,26)(H,22,23,25) ZZGSXADLHBGZJI-UHFFFAOYSA-N 127056 US8785459, 131 Serine/threonine-protein kinase B-raf Homo sapiens 451.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127056&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766665 225153403 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257082 Oc1cccc(Nc2ncnc3ccc(cc23)-c2ccccc2)c1 InChI=1S/C20H15N3O/c24-17-8-4-7-16(12-17)23-20-18-11-15(14-5-2-1-3-6-14)9-10-19(18)21-13-22-20/h1-13,24H,(H,21,22,23) PFKSSDJKCCMEPE-UHFFFAOYSA-N 127058 US8785459, 133 Serine/threonine-protein kinase B-raf Homo sapiens 168 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127058&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766667 225153405 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257083 COc1cc(ccc1O)-c1ccc2ncnc(Nc3c(F)cccc3F)c2c1 InChI=1S/C21H15F2N3O2/c1-28-19-10-13(6-8-18(19)27)12-5-7-17-14(9-12)21(25-11-24-17)26-20-15(22)3-2-4-16(20)23/h2-11,27H,1H3,(H,24,25,26) OFQVCTGBDZXJLC-UHFFFAOYSA-N 127059 US8785459, 134 Serine/threonine-protein kinase B-raf Homo sapiens 759.7 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127059&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766668 225153406 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257084 COc1cc(ccc1O)-c1ccc2ncnc(Nc3c(F)ccc4[nH]ncc34)c2c1 InChI=1S/C22H16FN5O2/c1-30-20-9-13(3-7-19(20)29)12-2-5-17-14(8-12)22(25-11-24-17)27-21-15-10-26-28-18(15)6-4-16(21)23/h2-11,29H,1H3,(H,26,28)(H,24,25,27) YRUUHVHWQRWHCT-UHFFFAOYSA-N 127061 US8785459, 136::US8785459, 149 Serine/threonine-protein kinase B-raf Homo sapiens 349.5 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127061&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766670 225153408 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257085 Nc1ccc(F)c(c1)-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H16FN5/c23-18-6-5-14(24)11-15(18)13-4-7-19-16(10-13)21(8-9-25-19)27-20-2-1-3-22-17(20)12-26-28-22/h1-12H,24H2,(H,25,27)(H,26,28) GCIPLOMLMJVRLX-UHFFFAOYSA-N 127062 US8785459, 137 Serine/threonine-protein kinase B-raf Homo sapiens 148.7 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127062&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766671 225153409 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257086 Nc1ccc(F)c(c1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C21H15FN6/c22-17-6-5-13(23)9-14(17)12-4-7-18-15(8-12)21(25-11-24-18)27-19-2-1-3-20-16(19)10-26-28-20/h1-11H,23H2,(H,26,28)(H,24,25,27) JJNKPOVRMNDYFE-UHFFFAOYSA-N 127063 US8785459, 138 Serine/threonine-protein kinase B-raf Homo sapiens 250.8 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127063&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766672 225153410 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257087 Oc1cccc(c1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C21H15N5O/c27-15-4-1-3-13(9-15)14-7-8-18-16(10-14)21(23-12-22-18)25-19-5-2-6-20-17(19)11-24-26-20/h1-12,27H,(H,24,26)(H,22,23,25) XHECPIUEWZFGGQ-UHFFFAOYSA-N 127068 US8785459, 143 Serine/threonine-protein kinase B-raf Homo sapiens 227.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127068&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766676 225153415 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257088 COc1cccc(c1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H17N5O/c1-28-16-5-2-4-14(10-16)15-8-9-19-17(11-15)22(24-13-23-19)26-20-6-3-7-21-18(20)12-25-27-21/h2-13H,1H3,(H,25,27)(H,23,24,26) YKZSYYCQJRZFMI-UHFFFAOYSA-N 127069 US8785459, 144 Serine/threonine-protein kinase B-raf Homo sapiens 308.9 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127069&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766677 225153416 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257089 COc1cccc(c1)-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C23H18N4O/c1-28-17-5-2-4-15(12-17)16-8-9-20-18(13-16)22(10-11-24-20)26-21-6-3-7-23-19(21)14-25-27-23/h2-14H,1H3,(H,24,26)(H,25,27) IKXJOEAHXPIXTE-UHFFFAOYSA-N 127048 US8785459, 123::US8785459, 146 Serine/threonine-protein kinase B-raf Homo sapiens 614.2 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127048&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766657 225153395 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257090 COc1ccc(cc1)-c1ccc2ncnc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H17N5O/c1-28-16-8-5-14(6-9-16)15-7-10-19-17(11-15)22(24-13-23-19)26-20-3-2-4-21-18(20)12-25-27-21/h2-13H,1H3,(H,25,27)(H,23,24,26) OFIJPQROYUEUGD-UHFFFAOYSA-N 127072 US8785459, 147 Serine/threonine-protein kinase B-raf Homo sapiens 679.7 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127072&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766679 225153419 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257091 Oc1cccc(c1)-c1ccc2nccc(Nc3cccc4[nH]ncc34)c2c1 InChI=1S/C22H16N4O/c27-16-4-1-3-14(11-16)15-7-8-19-17(12-15)21(9-10-23-19)25-20-5-2-6-22-18(20)13-24-26-22/h1-13,27H,(H,23,25)(H,24,26) PWYKRPPSSMIWFD-UHFFFAOYSA-N 127073 US8785459, 148 Serine/threonine-protein kinase B-raf Homo sapiens 229.9 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127073&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766680 225153420 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257092 COc1ccc(cc1)-c1ccc2ncnc(Oc3cccc(O)c3)c2c1 InChI=1S/C21H16N2O3/c1-25-17-8-5-14(6-9-17)15-7-10-20-19(11-15)21(23-13-22-20)26-18-4-2-3-16(24)12-18/h2-13,24H,1H3 NMGQBHKJOZFEDA-UHFFFAOYSA-N 127077 US8785459, 152 Serine/threonine-protein kinase B-raf Homo sapiens 131.4 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127077&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766683 225153424 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257093 N(c1cccc2[nH]ncc12)c1ncnc2ccc(cc12)-c1ccc2[nH]ncc2c1 InChI=1S/C22H15N7/c1-2-20(17-11-26-29-21(17)3-1)27-22-16-9-14(5-7-19(16)23-12-24-22)13-4-6-18-15(8-13)10-25-28-18/h1-12H,(H,25,28)(H,26,29)(H,23,24,27) OBYLOHFKFZLJSM-UHFFFAOYSA-N 127078 US8785459, 153 Serine/threonine-protein kinase B-raf Homo sapiens 188.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127078&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89645810 225153425 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257094 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cc(O)ccc3C)c2c1 InChI=1S/C22H19N3O3/c1-13-3-6-16(26)11-19(13)25-22-17-9-14(4-7-18(17)23-12-24-22)15-5-8-20(27)21(10-15)28-2/h3-12,26-27H,1-2H3,(H,23,24,25) FLTWWDWTIZAELE-UHFFFAOYSA-N 127079 US8785459, 154 Serine/threonine-protein kinase B-raf Homo sapiens 60 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127079&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766684 225153426 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257095 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cc(O)c(C)cc3F)c2c1 InChI=1S/C22H18FN3O3/c1-12-7-16(23)18(10-20(12)28)26-22-15-8-13(3-5-17(15)24-11-25-22)14-4-6-19(27)21(9-14)29-2/h3-11,27-28H,1-2H3,(H,24,25,26) MZDUBFXCVNFNTD-UHFFFAOYSA-N 127081 US8785459, 156 Serine/threonine-protein kinase B-raf Homo sapiens 57.3 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127081&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766686 225153428 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257096 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc(Cl)c(O)c3)c2c1 InChI=1S/C21H16ClN3O3/c1-28-20-9-13(3-7-18(20)26)12-2-6-17-15(8-12)21(24-11-23-17)25-14-4-5-16(22)19(27)10-14/h2-11,26-27H,1H3,(H,23,24,25) ACVWWDRVNBIHJC-UHFFFAOYSA-N 127082 US8785459, 157 Serine/threonine-protein kinase B-raf Homo sapiens 26.8 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127082&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766687 225153429 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257097 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cc(O)c(F)cc3F)c2c1 InChI=1S/C21H15F2N3O3/c1-29-20-7-12(3-5-18(20)27)11-2-4-16-13(6-11)21(25-10-24-16)26-17-9-19(28)15(23)8-14(17)22/h2-10,27-28H,1H3,(H,24,25,26) UQWLFAYGQCXZLD-UHFFFAOYSA-N 127083 US8785459, 158 Serine/threonine-protein kinase B-raf Homo sapiens 3.8 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127083&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766688 225153430 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257098 COc1cc(ccc1O)-c1ccc2ncnc(Nc3cc(O)c(Cl)cc3F)c2c1 InChI=1S/C21H15ClFN3O3/c1-29-20-7-12(3-5-18(20)27)11-2-4-16-13(6-11)21(25-10-24-16)26-17-9-19(28)14(22)8-15(17)23/h2-10,27-28H,1H3,(H,24,25,26) DYRMWMUNPOELJX-UHFFFAOYSA-N 127084 US8785459, 159 Serine/threonine-protein kinase B-raf Homo sapiens 11.1 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127084&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766689 225153431 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257099 Oc1cc(Nc2ncnc3ccc(cc23)-c2ccc(Cl)cc2)c(F)cc1F InChI=1S/C20H12ClF2N3O/c21-13-4-1-11(2-5-13)12-3-6-17-14(7-12)20(25-10-24-17)26-18-9-19(27)16(23)8-15(18)22/h1-10,27H,(H,24,25,26) LSFNHAFZZXYIDB-UHFFFAOYSA-N 127085 US8785459, 160 Serine/threonine-protein kinase B-raf Homo sapiens 8.9 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127085&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766690 225153432 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257100 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc(F)c(O)c3)c2c1 InChI=1S/C21H16FN3O3/c1-28-20-9-13(3-7-18(20)26)12-2-6-17-15(8-12)21(24-11-23-17)25-14-4-5-16(22)19(27)10-14/h2-11,26-27H,1H3,(H,23,24,25) WNVLKTDQXHZUGV-UHFFFAOYSA-N 127086 US8785459, 161 Serine/threonine-protein kinase B-raf Homo sapiens 16.9 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127086&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766691 225153433 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257101 COc1cc(ccc1O)-c1ccc2ncnc(Nc3ccc(F)c(O)c3F)c2c1 InChI=1S/C21H15F2N3O3/c1-29-18-9-12(3-7-17(18)27)11-2-5-15-13(8-11)21(25-10-24-15)26-16-6-4-14(22)20(28)19(16)23/h2-10,27-28H,1H3,(H,24,25,26) SUBDZIRWBNUWKU-UHFFFAOYSA-N 127087 US8785459, 162 Serine/threonine-protein kinase B-raf Homo sapiens 2.9 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127087&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766692 225153434 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257102 Oc1c(F)ccc(Nc2ncnc3ccc(cc23)-c2ccc3[nH]ncc3c2)c1F InChI=1S/C21H13F2N5O/c22-15-3-6-18(19(23)20(15)29)27-21-14-8-12(2-5-17(14)24-10-25-21)11-1-4-16-13(7-11)9-26-28-16/h1-10,29H,(H,26,28)(H,24,25,27) XEVJFJCQCIMXTL-UHFFFAOYSA-N 127088 US8785459, 163 Serine/threonine-protein kinase B-raf Homo sapiens 2.4 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127088&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71610729 225153435 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 257103 Oc1c(F)ccc(Nc2ncnc3ccc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C20H12ClF2N3O/c21-13-4-1-11(2-5-13)12-3-7-16-14(9-12)20(25-10-24-16)26-17-8-6-15(22)19(27)18(17)23/h1-10,27H,(H,24,25,26) MBPYRSULCBJQEY-UHFFFAOYSA-N 127089 US8785459, 164 Serine/threonine-protein kinase B-raf Homo sapiens 151 US Patent 10.7270/Q2M907BP aid1800571 US8785459 Huang, J; Liao, C; Chen, P Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127089&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86766693 225153436 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 334746 Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12 InChI=1S/C23H17ClN6OS/c1-12-2-7-16-15(8-9-26-22(16)29-14-5-3-13(24)4-6-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28) FHPTWZJZWOYCKG-UHFFFAOYSA-N 185584 US9156852, 1::USRE47451, Example 1 Serine/threonine-protein kinase B-raf Homo sapiens 121 US Patent 10.7270/Q24T6H4D aid1801726 US9156852 Bae, IH; Son, JB; Han, SM; Kwak, EJ; Kim, HS; Song, JY; Byun, EY; Jun, SA; Ahn, YG; Suh, KH Hanmi Pharm. Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=185584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=185584&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71622578 315516279 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 334747 COc1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1 InChI=1S/C24H20N6O2S/c1-13-3-8-17-16(9-10-26-23(17)29-14-4-6-15(32-2)7-5-14)19(13)30-24(31)18-11-33-21-20(18)27-12-28-22(21)25/h3-12H,1-2H3,(H,26,29)(H,30,31)(H2,25,27,28) LBYZLOWPJLYEGX-UHFFFAOYSA-N 185585 US9156852, 16::USRE47451, Example 16 Serine/threonine-protein kinase B-raf Homo sapiens 15 US Patent 10.7270/Q24T6H4D aid1801726 US9156852 Bae, IH; Son, JB; Han, SM; Kwak, EJ; Kim, HS; Song, JY; Byun, EY; Jun, SA; Ahn, YG; Suh, KH Hanmi Pharm. Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=185585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=185585&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71602593 315516280 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 334748 Cc1ccc2c(Nc3cccc(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12 InChI=1S/C23H17ClN6OS/c1-12-5-6-16-15(7-8-26-22(16)29-14-4-2-3-13(24)9-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28) RFEWCQAWLXXDQI-UHFFFAOYSA-N 185586 US9156852, 38::USRE47451, Example 38 Serine/threonine-protein kinase B-raf Homo sapiens 66 US Patent 10.7270/Q24T6H4D aid1801726 US9156852 Bae, IH; Son, JB; Han, SM; Kwak, EJ; Kim, HS; Song, JY; Byun, EY; Jun, SA; Ahn, YG; Suh, KH Hanmi Pharm. Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=185586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=185586&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89655060 315516281 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 334749 Cc1ccc2c(Nc3ccc(OC(F)F)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12 InChI=1S/C24H18F2N6O2S/c1-12-2-7-16-15(8-9-28-22(16)31-13-3-5-14(6-4-13)34-24(25)26)18(12)32-23(33)17-10-35-20-19(17)29-11-30-21(20)27/h2-11,24H,1H3,(H,28,31)(H,32,33)(H2,27,29,30) WSVRCSFMNFUWEQ-UHFFFAOYSA-N 185587 US9156852, 50::USRE47451, Example 50 Serine/threonine-protein kinase B-raf Homo sapiens 128 US Patent 10.7270/Q24T6H4D aid1801726 US9156852 Bae, IH; Son, JB; Han, SM; Kwak, EJ; Kim, HS; Song, JY; Byun, EY; Jun, SA; Ahn, YG; Suh, KH Hanmi Pharm. Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=185587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=185587&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621440 315516282 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 334750 CN(C)Cc1cc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)ccc1Cl InChI=1S/C26H24ClN7OS/c1-14-4-6-18-17(21(14)33-26(35)19-12-36-23-22(19)30-13-31-24(23)28)8-9-29-25(18)32-16-5-7-20(27)15(10-16)11-34(2)3/h4-10,12-13H,11H2,1-3H3,(H,29,32)(H,33,35)(H2,28,30,31) SLCWKPNWOMBQAA-UHFFFAOYSA-N 185588 US9156852, 59::USRE47451, Example 59 Serine/threonine-protein kinase B-raf Homo sapiens 42 US Patent 10.7270/Q24T6H4D aid1801726 US9156852 Bae, IH; Son, JB; Han, SM; Kwak, EJ; Kim, HS; Song, JY; Byun, EY; Jun, SA; Ahn, YG; Suh, KH Hanmi Pharm. Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=185588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=185588&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621754 315516283 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 334751 CC(=O)c1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1 InChI=1S/C25H20N6O2S/c1-13-3-8-18-17(9-10-27-24(18)30-16-6-4-15(5-7-16)14(2)32)20(13)31-25(33)19-11-34-22-21(19)28-12-29-23(22)26/h3-12H,1-2H3,(H,27,30)(H,31,33)(H2,26,28,29) VDPIYNSZQSYYGQ-UHFFFAOYSA-N 185589 US9156852, 83::USRE47451, Example 83 Serine/threonine-protein kinase B-raf Homo sapiens 12 US Patent 10.7270/Q24T6H4D aid1801726 US9156852 Bae, IH; Son, JB; Han, SM; Kwak, EJ; Kim, HS; Song, JY; Byun, EY; Jun, SA; Ahn, YG; Suh, KH Hanmi Pharm. Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=185589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=185589&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71622312 315516284 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 334752 Cc1ccc2c(Nc3ccc(F)c(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12 InChI=1S/C23H16ClFN6OS/c1-11-2-4-14-13(6-7-27-22(14)30-12-3-5-17(25)16(24)8-12)18(11)31-23(32)15-9-33-20-19(15)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29) GNDBDDNLWIOKDN-UHFFFAOYSA-N 185590 US9156852, 105::USRE47451, Example 105 Serine/threonine-protein kinase B-raf Homo sapiens 179 US Patent 10.7270/Q24T6H4D aid1801726 US9156852 Bae, IH; Son, JB; Han, SM; Kwak, EJ; Kim, HS; Song, JY; Byun, EY; Jun, SA; Ahn, YG; Suh, KH Hanmi Pharm. Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=185590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=185590&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71622865 315516285 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 334753 Cc1ccc2c(Nc3cccc(Cl)c3F)nccc2c1NC(=O)c1csc2c(N)ncnc12 InChI=1S/C23H16ClFN6OS/c1-11-5-6-13-12(7-8-27-22(13)30-16-4-2-3-15(24)17(16)25)18(11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29) KVCQTKNUUQOELD-UHFFFAOYSA-N 185591 US9156852, 116::USRE47451, Example 116 Serine/threonine-protein kinase B-raf Homo sapiens 56 US Patent 10.7270/Q24T6H4D aid1801726 US9156852 Bae, IH; Son, JB; Han, SM; Kwak, EJ; Kim, HS; Song, JY; Byun, EY; Jun, SA; Ahn, YG; Suh, KH Hanmi Pharm. Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=185591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=185591&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search V1Y 6XFP 89655386 315516286 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 344427 CNc1cc2nc(C)c(cc2cn1)-c1cc(NC(=O)NCCC(C)(C)C)ccc1F InChI=1S/C23H28FN5O/c1-14-17(10-15-13-27-21(25-5)12-20(15)28-14)18-11-16(6-7-19(18)24)29-22(30)26-9-8-23(2,3)4/h6-7,10-13H,8-9H2,1-5H3,(H,25,27)(H2,26,29,30) ACGNJFZSGIKELN-UHFFFAOYSA-N 192503 US9187474, 18 Serine/threonine-protein kinase B-raf Homo sapiens 35 US Patent 10.7270/Q2HH6HWK aid1801903 US9187474 Flynn, DL; Kaufman, MD; Vogeti, L; Wise, S; Lu, W; Smith, B; Caldwell, TM; Patt, WC; Henry, JR; Hipskind, PA; Peng, S Deciphera Pharmaceuticals LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192503&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71737024 317228098 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 344431 CNc1cc2nc(C)c(cc2cn1)-c1cc(NC(=O)NCCC(C)(C)F)c(F)cc1C InChI=1S/C23H27F2N5O/c1-13-8-18(24)20(30-22(31)27-7-6-23(3,4)25)10-16(13)17-9-15-12-28-21(26-5)11-19(15)29-14(17)2/h8-12H,6-7H2,1-5H3,(H,26,28)(H2,27,30,31) WMVXSEQUHAGMDB-UHFFFAOYSA-N 192504 US9187474, 76 Serine/threonine-protein kinase B-raf Homo sapiens 16 US Patent 10.7270/Q2HH6HWK aid1801903 US9187474 Flynn, DL; Kaufman, MD; Vogeti, L; Wise, S; Lu, W; Smith, B; Caldwell, TM; Patt, WC; Henry, JR; Hipskind, PA; Peng, S Deciphera Pharmaceuticals LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192504&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71737335 317228099 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351019 CC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H17F2N7O2S/c1-10(2)31(29,30)28-13-6-5-12(20)16(14(13)21)27-18-11(4-3-7-22-18)15-17-19(25-8-23-15)26-9-24-17/h3-10,28H,1-2H3,(H,22,27)(H,23,24,25,26) LJGJKSMJLUENHX-UHFFFAOYSA-N 197673 US9216981, 1 Serine/threonine-protein kinase B-raf Homo sapiens 17 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344791 318488790 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351020 Fc1ccc(NS(=O)(=O)c2cccc(c2)C(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C23H14F5N7O2S/c24-15-6-7-16(35-38(36,37)13-4-1-3-12(9-13)23(26,27)28)17(25)19(15)34-21-14(5-2-8-29-21)18-20-22(32-10-30-18)33-11-31-20/h1-11,35H,(H,29,34)(H,30,31,32,33) GRPSMJSHOIVSEK-UHFFFAOYSA-N 197674 US9216981, 2 Serine/threonine-protein kinase B-raf Homo sapiens 8.8 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197674&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344792 318488791 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351021 Fc1ccc(NS(=O)(=O)c2ccc(cc2)C(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C23H14F5N7O2S/c24-15-7-8-16(35-38(36,37)13-5-3-12(4-6-13)23(26,27)28)17(25)19(15)34-21-14(2-1-9-29-21)18-20-22(32-10-30-18)33-11-31-20/h1-11,35H,(H,29,34)(H,30,31,32,33) OSQGVCTZCJJOFF-UHFFFAOYSA-N 197675 US9216981, 3 Serine/threonine-protein kinase B-raf Homo sapiens 30 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197675&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344793 318488792 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351022 Fc1ccc(NS(=O)(=O)c2cccs2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H13F2N7O2S2/c21-12-5-6-13(29-33(30,31)14-4-2-8-32-14)15(22)17(12)28-19-11(3-1-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-10,29H,(H,23,28)(H,24,25,26,27) AUPADWFQWOIWBW-UHFFFAOYSA-N 197676 US9216981, 4 Serine/threonine-protein kinase B-raf Homo sapiens 12 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197676&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344794 318488793 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351023 CCCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H17F2N7O2S/c1-2-8-31(29,30)28-13-6-5-12(20)16(14(13)21)27-18-11(4-3-7-22-18)15-17-19(25-9-23-15)26-10-24-17/h3-7,9-10,28H,2,8H2,1H3,(H,22,27)(H,23,24,25,26) ZCFRMOFRDWXLRB-UHFFFAOYSA-N 197677 US9216981, 5::US9550781, 1 Serine/threonine-protein kinase B-raf Homo sapiens 23 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197677&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344795 318488794 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351024 Fc1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H13Cl2F2N7O2S/c23-13-4-3-11(8-14(13)24)36(34,35)33-16-6-5-15(25)19(17(16)26)32-21-12(2-1-7-27-21)18-20-22(30-9-28-18)31-10-29-20/h1-10,33H,(H,27,32)(H,28,29,30,31) NUQZQAPNDMNLLN-UHFFFAOYSA-N 197678 US9216981, 6 Serine/threonine-protein kinase B-raf Homo sapiens 720 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197678&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344893 318488795 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351025 Fc1ccc(NS(=O)(=O)c2cc3ccccc3o2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C24H15F2N7O3S/c25-15-7-8-16(33-37(34,35)18-10-13-4-1-2-6-17(13)36-18)19(26)21(15)32-23-14(5-3-9-27-23)20-22-24(30-11-28-20)31-12-29-22/h1-12,33H,(H,27,32)(H,28,29,30,31) RLIOVQAWYFLLCG-UHFFFAOYSA-N 197679 US9216981, 7 Serine/threonine-protein kinase B-raf Homo sapiens 832 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197679&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344894 318488796 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351026 Fc1ccc(NS(=O)(=O)c2ccc(Cl)cc2F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H13ClF3N7O2S/c23-11-3-6-16(14(25)8-11)36(34,35)33-15-5-4-13(24)19(17(15)26)32-21-12(2-1-7-27-21)18-20-22(30-9-28-18)31-10-29-20/h1-10,33H,(H,27,32)(H,28,29,30,31) MTPJVAPNIHBGGV-UHFFFAOYSA-N 197680 US9216981, 8 Serine/threonine-protein kinase B-raf Homo sapiens 33.7 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197680&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344895 318488797 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351027 [O-][N+](=O)c1ccccc1CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C23H16F2N8O4S/c24-15-7-8-16(32-38(36,37)10-13-4-1-2-6-17(13)33(34)35)18(25)20(15)31-22-14(5-3-9-26-22)19-21-23(29-11-27-19)30-12-28-21/h1-9,11-12,32H,10H2,(H,26,31)(H,27,28,29,30) MAXUDKMCUTVIEB-UHFFFAOYSA-N 197681 US9216981, 9 Serine/threonine-protein kinase B-raf Homo sapiens 1500 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197681&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67963146 318488798 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351028 COc1ccc(cc1OC)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C24H19F2N7O4S/c1-36-17-8-5-13(10-18(17)37-2)38(34,35)33-16-7-6-15(25)21(19(16)26)32-23-14(4-3-9-27-23)20-22-24(30-11-28-20)31-12-29-22/h3-12,33H,1-2H3,(H,27,32)(H,28,29,30,31) KTMMOPBQRGMNBC-UHFFFAOYSA-N 197682 US9216981, 10 Serine/threonine-protein kinase B-raf Homo sapiens 1200 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197682&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344897 318488799 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351029 Fc1ccc(NS(=O)(=O)C2CCCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H21F2N7O2S/c23-15-8-9-16(31-34(32,33)13-5-2-1-3-6-13)17(24)19(15)30-21-14(7-4-10-25-21)18-20-22(28-11-26-18)29-12-27-20/h4,7-13,31H,1-3,5-6H2,(H,25,30)(H,26,27,28,29) HELVMFLMFAYVHW-UHFFFAOYSA-N 197683 US9216981, 11 Serine/threonine-protein kinase B-raf Homo sapiens 206 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197683&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344993 318488800 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351030 Fc1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C23H14F5N7O3S/c24-15-7-8-16(35-39(36,37)13-5-3-12(4-6-13)38-23(26,27)28)17(25)19(15)34-21-14(2-1-9-29-21)18-20-22(32-10-30-18)33-11-31-20/h1-11,35H,(H,29,34)(H,30,31,32,33) IARQQKDGLMSINT-UHFFFAOYSA-N 197684 US9216981, 12 Serine/threonine-protein kinase B-raf Homo sapiens 610 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197684&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344994 318488801 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351031 Fc1ccc(c(c1)C(F)(F)F)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C23H13F6N7O2S/c24-11-3-6-16(13(8-11)23(27,28)29)39(37,38)36-15-5-4-14(25)19(17(15)26)35-21-12(2-1-7-30-21)18-20-22(33-9-31-18)34-10-32-20/h1-10,36H,(H,30,35)(H,31,32,33,34) MODKADBEDFUKGW-UHFFFAOYSA-N 197685 US9216981, 13 Serine/threonine-protein kinase B-raf Homo sapiens 420 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197685&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344995 318488802 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351032 Cc1c(Cl)cccc1S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C23H16ClF2N7O2S/c1-12-14(24)5-2-6-17(12)36(34,35)33-16-8-7-15(25)20(18(16)26)32-22-13(4-3-9-27-22)19-21-23(30-10-28-19)31-11-29-21/h2-11,33H,1H3,(H,27,32)(H,28,29,30,31) XTFGLALDZROXLK-UHFFFAOYSA-N 197686 US9216981, 14 Serine/threonine-protein kinase B-raf Homo sapiens 2 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197686&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344996 318488803 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351033 Fc1ccc(NS(=O)(=O)c2ccco2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H13F2N7O3S/c21-12-5-6-13(29-33(30,31)14-4-2-8-32-14)15(22)17(12)28-19-11(3-1-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-10,29H,(H,23,28)(H,24,25,26,27) QZRYHOXAGKASKV-UHFFFAOYSA-N 197687 US9216981, 15 Serine/threonine-protein kinase B-raf Homo sapiens 1 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197687&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344997 318488804 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351034 COC(=O)c1sccc1S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H15F2N7O4S2/c1-35-22(32)19-14(6-8-36-19)37(33,34)31-13-5-4-12(23)17(15(13)24)30-20-11(3-2-7-25-20)16-18-21(28-9-26-16)29-10-27-18/h2-10,31H,1H3,(H,25,30)(H,26,27,28,29) NQISMKJSCFLCFF-UHFFFAOYSA-N 197688 US9216981, 16 Serine/threonine-protein kinase B-raf Homo sapiens 1500 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197688&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345093 318488805 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351035 Fc1ccc(NS(=O)(=O)c2ccsc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H13F2N7O2S2/c21-13-3-4-14(29-33(30,31)11-5-7-32-8-11)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-10,29H,(H,23,28)(H,24,25,26,27) YSBVTNXKLLPITL-UHFFFAOYSA-N 197689 US9216981, 17::US9550781, 24 Serine/threonine-protein kinase B-raf Homo sapiens 7 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197689&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345094 318488806 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351036 Fc1ccc(NS(=O)(=O)c2ccoc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H13F2N7O3S/c21-13-3-4-14(29-33(30,31)11-5-7-32-8-11)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-10,29H,(H,23,28)(H,24,25,26,27) ACIXGVIVJZJKNT-UHFFFAOYSA-N 50038473 CHEMBL3354844::US9216981, 18 Serine/threonine-protein kinase B-raf Homo sapiens 1 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038473&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 56965341 313067299 CHEMBL3354844 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351037 Fc1ccc(NS(=O)(=O)C2CC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C19H15F2N7O2S/c20-12-5-6-13(28-31(29,30)10-3-4-10)14(21)16(12)27-18-11(2-1-7-22-18)15-17-19(25-8-23-15)26-9-24-17/h1-2,5-10,28H,3-4H2,(H,22,27)(H,23,24,25,26) SMMQTLKZQUWOFV-UHFFFAOYSA-N 197690 US9216981, 19 Serine/threonine-protein kinase B-raf Homo sapiens 50 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197690&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345095 318488807 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351038 Cc1nc(C)c(s1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C21H16F2N8O2S2/c1-10-21(34-11(2)29-10)35(32,33)31-14-6-5-13(22)17(15(14)23)30-19-12(4-3-7-24-19)16-18-20(27-8-25-16)28-9-26-18/h3-9,31H,1-2H3,(H,24,30)(H,25,26,27,28) NRXIQNZUPYHZJU-UHFFFAOYSA-N 197691 US9216981, 20 Serine/threonine-protein kinase B-raf Homo sapiens 160 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197691&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345096 318488808 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351039 Fc1ccc(NS(=O)(=O)N2CCOCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H18F2N8O3S/c21-13-3-4-14(29-34(31,32)30-6-8-33-9-7-30)15(22)17(13)28-19-12(2-1-5-23-19)16-18-20(26-10-24-16)27-11-25-18/h1-5,10-11,29H,6-9H2,(H,23,28)(H,24,25,26,27) PVLBWLQBZCGLQR-UHFFFAOYSA-N 197692 US9216981, 21 Serine/threonine-protein kinase B-raf Homo sapiens 1300 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197692&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345097 318488809 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351040 Cn1cnc(c1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H15F2N9O2S/c1-31-7-14(28-10-31)34(32,33)30-13-5-4-12(21)17(15(13)22)29-19-11(3-2-6-23-19)16-18-20(26-8-24-16)27-9-25-18/h2-10,30H,1H3,(H,23,29)(H,24,25,26,27) MGCDELBBUMYCBC-UHFFFAOYSA-N 197693 US9216981, 22 Serine/threonine-protein kinase B-raf Homo sapiens 1800 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197693&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345213 318488810 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351041 Cc1ccc(o1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C21H15F2N7O3S/c1-11-4-7-15(33-11)34(31,32)30-14-6-5-13(22)18(16(14)23)29-20-12(3-2-8-24-20)17-19-21(27-9-25-17)28-10-26-19/h2-10,30H,1H3,(H,24,29)(H,25,26,27,28) QIMUSZMFBWTWNO-UHFFFAOYSA-N 197694 US9216981, 23 Serine/threonine-protein kinase B-raf Homo sapiens 15 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197694&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345214 318488811 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351042 Fc1ccc(NS(=O)(=O)c2occc2C2OCCO2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C23H17F2N7O5S/c24-14-3-4-15(32-38(33,34)23-13(5-7-37-23)22-35-8-9-36-22)16(25)18(14)31-20-12(2-1-6-26-20)17-19-21(29-10-27-17)30-11-28-19/h1-7,10-11,22,32H,8-9H2,(H,26,31)(H,27,28,29,30) FSKBDHVRFZLKSB-UHFFFAOYSA-N 197695 US9216981, 24 Serine/threonine-protein kinase B-raf Homo sapiens 220 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197695&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345215 318488812 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351043 Cc1cc(c(C)o1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H17F2N7O3S/c1-11-8-16(12(2)34-11)35(32,33)31-15-6-5-14(23)19(17(15)24)30-21-13(4-3-7-25-21)18-20-22(28-9-26-18)29-10-27-20/h3-10,31H,1-2H3,(H,25,30)(H,26,27,28,29) MOZZMHNKOZULQL-UHFFFAOYSA-N 197696 US9216981, 25 Serine/threonine-protein kinase B-raf Homo sapiens 15 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197696&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345216 318488813 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351044 Cc1cc(c(o1)C(F)(F)F)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H14F5N7O3S/c1-10-7-14(19(37-10)22(25,26)27)38(35,36)34-13-5-4-12(23)17(15(13)24)33-20-11(3-2-6-28-20)16-18-21(31-8-29-16)32-9-30-18/h2-9,34H,1H3,(H,28,33)(H,29,30,31,32) AAADXMXYZRUUBD-UHFFFAOYSA-N 197697 US9216981, 26 Serine/threonine-protein kinase B-raf Homo sapiens 30 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197697&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345217 318488814 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351045 Cc1cccc(Cl)c1S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C23H16ClF2N7O2S/c1-12-4-2-6-14(24)21(12)36(34,35)33-16-8-7-15(25)19(17(16)26)32-22-13(5-3-9-27-22)18-20-23(30-10-28-18)31-11-29-20/h2-11,33H,1H3,(H,27,32)(H,28,29,30,31) TVQBTBGIQXUFKX-UHFFFAOYSA-N 197698 US9216981, 27 Serine/threonine-protein kinase B-raf Homo sapiens 80 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197698&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345325 318488815 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351046 Fc1ccc(cc1Cl)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H13ClF3N7O2S/c23-13-8-11(3-4-14(13)24)36(34,35)33-16-6-5-15(25)19(17(16)26)32-21-12(2-1-7-27-21)18-20-22(30-9-28-18)31-10-29-20/h1-10,33H,(H,27,32)(H,28,29,30,31) SCRNCGHMVGMPTI-UHFFFAOYSA-N 197699 US9216981, 28 Serine/threonine-protein kinase B-raf Homo sapiens 300 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197699&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345326 318488816 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351047 Fc1ccc(NS(=O)(=O)c2cccc(Cl)c2F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H13ClF3N7O2S/c23-12-4-1-5-15(16(12)25)36(34,35)33-14-7-6-13(24)19(17(14)26)32-21-11(3-2-8-27-21)18-20-22(30-9-28-18)31-10-29-20/h1-10,33H,(H,27,32)(H,28,29,30,31) PXGZTGOCMAAVGO-UHFFFAOYSA-N 197700 US9216981, 29 Serine/threonine-protein kinase B-raf Homo sapiens 80 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197700&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345327 318488817 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351048 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H14F2N8O2S/c22-14-5-6-15(31-34(32,33)12-3-1-7-24-9-12)16(23)18(14)30-20-13(4-2-8-25-20)17-19-21(28-10-26-17)29-11-27-19/h1-11,31H,(H,25,30)(H,26,27,28,29) JTESGLUEGOKQOX-UHFFFAOYSA-N 197701 US9216981, 30 Serine/threonine-protein kinase B-raf Homo sapiens 4 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197701&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345328 318488818 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351049 Cc1ccccc1S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C23H17F2N7O2S/c1-13-5-2-3-7-17(13)35(33,34)32-16-9-8-15(24)20(18(16)25)31-22-14(6-4-10-26-22)19-21-23(29-11-27-19)30-12-28-21/h2-12,32H,1H3,(H,26,31)(H,27,28,29,30) YREQTIVVMCLZJB-UHFFFAOYSA-N 197702 US9216981, 31 Serine/threonine-protein kinase B-raf Homo sapiens 50 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197702&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345329 318488819 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351050 Fc1ccc(NS(=O)(=O)c2ccccc2Cl)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H14ClF2N7O2S/c23-13-5-1-2-6-16(13)35(33,34)32-15-8-7-14(24)19(17(15)25)31-21-12(4-3-9-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) FJDHTUKBHFXBLS-UHFFFAOYSA-N 197703 US9216981, 32 Serine/threonine-protein kinase B-raf Homo sapiens 30 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197703&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343764 318488820 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351051 Fc1ccc(NS(=O)(=O)c2cccc(Cl)c2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H14ClF2N7O2S/c23-12-3-1-4-13(9-12)35(33,34)32-16-7-6-15(24)19(17(16)25)31-21-14(5-2-8-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) TUORYODHIROMIM-UHFFFAOYSA-N 197704 US9216981, 33 Serine/threonine-protein kinase B-raf Homo sapiens 80 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197704&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343974 318488821 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351052 Fc1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H13Cl2F2N7O2S/c23-12-4-1-5-15(16(12)24)36(34,35)33-14-7-6-13(25)19(17(14)26)32-21-11(3-2-8-27-21)18-20-22(30-9-28-18)31-10-29-20/h1-10,33H,(H,27,32)(H,28,29,30,31) OXDIFBAVMNZPAH-UHFFFAOYSA-N 197705 US9216981, 34 Serine/threonine-protein kinase B-raf Homo sapiens 40 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197705&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343765 318488822 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351053 Fc1ccc(NS(=O)(=O)c2ccccc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H15F2N7O2S/c23-15-8-9-16(31-34(32,33)13-5-2-1-3-6-13)17(24)19(15)30-21-14(7-4-10-25-21)18-20-22(28-11-26-18)29-12-27-20/h1-12,31H,(H,25,30)(H,26,27,28,29) UHPAFPKCOMSYMO-UHFFFAOYSA-N 197706 US9216981, 35::US9550781, 15 Serine/threonine-protein kinase B-raf Homo sapiens 20 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197706&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343766 318488823 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351054 Fc1ccc(NS(=O)(=O)c2cccc3CCOc23)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C24H17F2N7O3S/c25-15-6-7-16(33-37(34,35)17-5-1-3-13-8-10-36-22(13)17)18(26)20(15)32-23-14(4-2-9-27-23)19-21-24(30-11-28-19)31-12-29-21/h1-7,9,11-12,33H,8,10H2,(H,27,32)(H,28,29,30,31) HQLSNMHUQKMLRG-UHFFFAOYSA-N 197707 US9216981, 36 Serine/threonine-protein kinase B-raf Homo sapiens 1020 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197707&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343767 318488824 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351055 Fc1ccc(NS(=O)(=O)c2cccc3ccoc23)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C24H15F2N7O3S/c25-15-6-7-16(33-37(34,35)17-5-1-3-13-8-10-36-22(13)17)18(26)20(15)32-23-14(4-2-9-27-23)19-21-24(30-11-28-19)31-12-29-21/h1-12,33H,(H,27,32)(H,28,29,30,31) SPWVDJAZRHNFJA-UHFFFAOYSA-N 197708 US9216981, 37 Serine/threonine-protein kinase B-raf Homo sapiens 90 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197708&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343768 318488825 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351056 Fc1ccc(NS(=O)(=O)c2cccc3CCCOc23)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C25H19F2N7O3S/c26-16-8-9-17(34-38(35,36)18-7-1-4-14-5-3-11-37-23(14)18)19(27)21(16)33-24-15(6-2-10-28-24)20-22-25(31-12-29-20)32-13-30-22/h1-2,4,6-10,12-13,34H,3,5,11H2,(H,28,33)(H,29,30,31,32) BZIPSTPBTUOWRZ-UHFFFAOYSA-N 197709 US9216981, 38 Serine/threonine-protein kinase B-raf Homo sapiens 900 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197709&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343867 318488826 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351057 Cc1nc2ccc(cc2s1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C24H16F2N8O2S2/c1-12-32-16-6-4-13(9-18(16)37-12)38(35,36)34-17-7-5-15(25)21(19(17)26)33-23-14(3-2-8-27-23)20-22-24(30-10-28-20)31-11-29-22/h2-11,34H,1H3,(H,27,33)(H,28,29,30,31) JPSGNCLLQOXYGW-UHFFFAOYSA-N 197710 US9216981, 39 Serine/threonine-protein kinase B-raf Homo sapiens 400 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197710&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343868 318488827 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351058 Cn1ccc2cc(ccc12)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C25H18F2N8O2S/c1-35-10-8-14-11-15(4-7-19(14)35)38(36,37)34-18-6-5-17(26)22(20(18)27)33-24-16(3-2-9-28-24)21-23-25(31-12-29-21)32-13-30-23/h2-13,34H,1H3,(H,28,33)(H,29,30,31,32) IBBWOWZXOLJUHZ-UHFFFAOYSA-N 197711 US9216981, 40 Serine/threonine-protein kinase B-raf Homo sapiens >10000 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197711&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343869 318488828 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351059 Cn1ccc2c(cccc12)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C25H18F2N8O2S/c1-35-11-9-14-18(35)5-2-6-19(14)38(36,37)34-17-8-7-16(26)22(20(17)27)33-24-15(4-3-10-28-24)21-23-25(31-12-29-21)32-13-30-23/h2-13,34H,1H3,(H,28,33)(H,29,30,31,32) SPARSQURLAWSDS-UHFFFAOYSA-N 197712 US9216981, 41 Serine/threonine-protein kinase B-raf Homo sapiens 550 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197712&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343870 318488829 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351060 Cn1ccc2cccc(c12)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C25H18F2N8O2S/c1-35-11-9-14-4-2-6-18(23(14)35)38(36,37)34-17-8-7-16(26)21(19(17)27)33-24-15(5-3-10-28-24)20-22-25(31-12-29-20)32-13-30-22/h2-13,34H,1H3,(H,28,33)(H,29,30,31,32) PLBMBARKUQBUQN-UHFFFAOYSA-N 197713 US9216981, 42 Serine/threonine-protein kinase B-raf Homo sapiens 800 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197713&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343871 318488830 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351061 Cn1cc(cn1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H15F2N9O2S/c1-31-8-11(7-28-31)34(32,33)30-14-5-4-13(21)17(15(14)22)29-19-12(3-2-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h2-10,30H,1H3,(H,23,29)(H,24,25,26,27) MFGDWGYOUFSTFA-UHFFFAOYSA-N 197714 US9216981, 43 Serine/threonine-protein kinase B-raf Homo sapiens 120 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197714&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343972 318488831 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351062 Fc1ccc(NS(=O)(=O)c2ccc(Cl)s2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H12ClF2N7O2S2/c21-13-5-6-14(33-13)34(31,32)30-12-4-3-11(22)17(15(12)23)29-19-10(2-1-7-24-19)16-18-20(27-8-25-16)28-9-26-18/h1-9,30H,(H,24,29)(H,25,26,27,28) GNIBUZPNXORXMI-UHFFFAOYSA-N 197715 US9216981, 44 Serine/threonine-protein kinase B-raf Homo sapiens 20 7.2 30.00 C US Patent 10.7270/Q2BC3XCR aid1802041 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197715&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343973 318488832 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351063 CC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H17F2N7O2S/c1-10(2)31(29,30)28-13-6-5-12(20)16(14(13)21)27-18-11(4-3-7-22-18)15-17-19(25-8-23-15)26-9-24-17/h3-10,28H,1-2H3,(H,22,27)(H,23,24,25,26) LJGJKSMJLUENHX-UHFFFAOYSA-N 197673 US9216981, 1 Serine/threonine-protein kinase B-raf Homo sapiens 120 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344791 318488790 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351064 Fc1ccc(NS(=O)(=O)c2cccc(c2)C(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C23H14F5N7O2S/c24-15-6-7-16(35-38(36,37)13-4-1-3-12(9-13)23(26,27)28)17(25)19(15)34-21-14(5-2-8-29-21)18-20-22(32-10-30-18)33-11-31-20/h1-11,35H,(H,29,34)(H,30,31,32,33) GRPSMJSHOIVSEK-UHFFFAOYSA-N 197674 US9216981, 2 Serine/threonine-protein kinase B-raf Homo sapiens 230 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197674&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344792 318488791 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351065 Fc1ccc(NS(=O)(=O)c2ccc(cc2)C(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C23H14F5N7O2S/c24-15-7-8-16(35-38(36,37)13-5-3-12(4-6-13)23(26,27)28)17(25)19(15)34-21-14(2-1-9-29-21)18-20-22(32-10-30-18)33-11-31-20/h1-11,35H,(H,29,34)(H,30,31,32,33) OSQGVCTZCJJOFF-UHFFFAOYSA-N 197675 US9216981, 3 Serine/threonine-protein kinase B-raf Homo sapiens 5200 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197675&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344793 318488792 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351066 Fc1ccc(NS(=O)(=O)c2cccs2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H13F2N7O2S2/c21-12-5-6-13(29-33(30,31)14-4-2-8-32-14)15(22)17(12)28-19-11(3-1-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-10,29H,(H,23,28)(H,24,25,26,27) AUPADWFQWOIWBW-UHFFFAOYSA-N 197676 US9216981, 4 Serine/threonine-protein kinase B-raf Homo sapiens 30 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197676&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344794 318488793 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351067 CCCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H17F2N7O2S/c1-2-8-31(29,30)28-13-6-5-12(20)16(14(13)21)27-18-11(4-3-7-22-18)15-17-19(25-9-23-15)26-10-24-17/h3-7,9-10,28H,2,8H2,1H3,(H,22,27)(H,23,24,25,26) ZCFRMOFRDWXLRB-UHFFFAOYSA-N 197677 US9216981, 5::US9550781, 1 Serine/threonine-protein kinase B-raf Homo sapiens 310 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197677&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344795 318488794 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351068 Fc1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H13Cl2F2N7O2S/c23-13-4-3-11(8-14(13)24)36(34,35)33-16-6-5-15(25)19(17(16)26)32-21-12(2-1-7-27-21)18-20-22(30-9-28-18)31-10-29-20/h1-10,33H,(H,27,32)(H,28,29,30,31) NUQZQAPNDMNLLN-UHFFFAOYSA-N 197678 US9216981, 6 Serine/threonine-protein kinase B-raf Homo sapiens 2800 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197678&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344893 318488795 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351069 Fc1ccc(NS(=O)(=O)c2cc3ccccc3o2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C24H15F2N7O3S/c25-15-7-8-16(33-37(34,35)18-10-13-4-1-2-6-17(13)36-18)19(26)21(15)32-23-14(5-3-9-27-23)20-22-24(30-11-28-20)31-12-29-22/h1-12,33H,(H,27,32)(H,28,29,30,31) RLIOVQAWYFLLCG-UHFFFAOYSA-N 197679 US9216981, 7 Serine/threonine-protein kinase B-raf Homo sapiens 4300 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197679&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344894 318488796 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351070 Fc1ccc(NS(=O)(=O)c2ccc(Cl)cc2F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H13ClF3N7O2S/c23-11-3-6-16(14(25)8-11)36(34,35)33-15-5-4-13(24)19(17(15)26)32-21-12(2-1-7-27-21)18-20-22(30-9-28-18)31-10-29-20/h1-10,33H,(H,27,32)(H,28,29,30,31) MTPJVAPNIHBGGV-UHFFFAOYSA-N 197680 US9216981, 8 Serine/threonine-protein kinase B-raf Homo sapiens 700 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197680&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344895 318488797 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351071 [O-][N+](=O)c1ccccc1CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C23H16F2N8O4S/c24-15-7-8-16(32-38(36,37)10-13-4-1-2-6-17(13)33(34)35)18(25)20(15)31-22-14(5-3-9-26-22)19-21-23(29-11-27-19)30-12-28-21/h1-9,11-12,32H,10H2,(H,26,31)(H,27,28,29,30) MAXUDKMCUTVIEB-UHFFFAOYSA-N 197681 US9216981, 9 Serine/threonine-protein kinase B-raf Homo sapiens 11200 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197681&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67963146 318488798 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351072 COc1ccc(cc1OC)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C24H19F2N7O4S/c1-36-17-8-5-13(10-18(17)37-2)38(34,35)33-16-7-6-15(25)21(19(16)26)32-23-14(4-3-9-27-23)20-22-24(30-11-28-20)31-12-29-22/h3-12,33H,1-2H3,(H,27,32)(H,28,29,30,31) KTMMOPBQRGMNBC-UHFFFAOYSA-N 197682 US9216981, 10 Serine/threonine-protein kinase B-raf Homo sapiens 10200 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197682&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344897 318488799 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351073 Fc1ccc(NS(=O)(=O)C2CCCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H21F2N7O2S/c23-15-8-9-16(31-34(32,33)13-5-2-1-3-6-13)17(24)19(15)30-21-14(7-4-10-25-21)18-20-22(28-11-26-18)29-12-27-20/h4,7-13,31H,1-3,5-6H2,(H,25,30)(H,26,27,28,29) HELVMFLMFAYVHW-UHFFFAOYSA-N 197683 US9216981, 11 Serine/threonine-protein kinase B-raf Homo sapiens 340 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197683&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344993 318488800 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351074 Fc1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C23H14F5N7O3S/c24-15-7-8-16(35-39(36,37)13-5-3-12(4-6-13)38-23(26,27)28)17(25)19(15)34-21-14(2-1-9-29-21)18-20-22(32-10-30-18)33-11-31-20/h1-11,35H,(H,29,34)(H,30,31,32,33) IARQQKDGLMSINT-UHFFFAOYSA-N 197684 US9216981, 12 Serine/threonine-protein kinase B-raf Homo sapiens 600 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197684&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344994 318488801 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351075 Fc1ccc(c(c1)C(F)(F)F)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C23H13F6N7O2S/c24-11-3-6-16(13(8-11)23(27,28)29)39(37,38)36-15-5-4-14(25)19(17(15)26)35-21-12(2-1-7-30-21)18-20-22(33-9-31-18)34-10-32-20/h1-10,36H,(H,30,35)(H,31,32,33,34) MODKADBEDFUKGW-UHFFFAOYSA-N 197685 US9216981, 13 Serine/threonine-protein kinase B-raf Homo sapiens 150 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197685&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344995 318488802 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351076 Cc1c(Cl)cccc1S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C23H16ClF2N7O2S/c1-12-14(24)5-2-6-17(12)36(34,35)33-16-8-7-15(25)20(18(16)26)32-22-13(4-3-9-27-22)19-21-23(30-10-28-19)31-11-29-21/h2-11,33H,1H3,(H,27,32)(H,28,29,30,31) XTFGLALDZROXLK-UHFFFAOYSA-N 197686 US9216981, 14 Serine/threonine-protein kinase B-raf Homo sapiens 6 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197686&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344996 318488803 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351077 Fc1ccc(NS(=O)(=O)c2ccco2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H13F2N7O3S/c21-12-5-6-13(29-33(30,31)14-4-2-8-32-14)15(22)17(12)28-19-11(3-1-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-10,29H,(H,23,28)(H,24,25,26,27) QZRYHOXAGKASKV-UHFFFAOYSA-N 197687 US9216981, 15 Serine/threonine-protein kinase B-raf Homo sapiens 11000 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197687&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344997 318488804 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351078 COC(=O)c1sccc1S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H15F2N7O4S2/c1-35-22(32)19-14(6-8-36-19)37(33,34)31-13-5-4-12(23)17(15(13)24)30-20-11(3-2-7-25-20)16-18-21(28-9-26-16)29-10-27-18/h2-10,31H,1H3,(H,25,30)(H,26,27,28,29) NQISMKJSCFLCFF-UHFFFAOYSA-N 197688 US9216981, 16 Serine/threonine-protein kinase B-raf Homo sapiens 9600 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197688&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345093 318488805 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351079 Fc1ccc(NS(=O)(=O)c2ccsc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H13F2N7O2S2/c21-13-3-4-14(29-33(30,31)11-5-7-32-8-11)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-10,29H,(H,23,28)(H,24,25,26,27) YSBVTNXKLLPITL-UHFFFAOYSA-N 197689 US9216981, 17::US9550781, 24 Serine/threonine-protein kinase B-raf Homo sapiens 40 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197689&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345094 318488806 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351080 Fc1ccc(NS(=O)(=O)c2ccoc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H13F2N7O3S/c21-13-3-4-14(29-33(30,31)11-5-7-32-8-11)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-10,29H,(H,23,28)(H,24,25,26,27) ACIXGVIVJZJKNT-UHFFFAOYSA-N 50038473 CHEMBL3354844::US9216981, 18 Serine/threonine-protein kinase B-raf Homo sapiens 2 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038473&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 56965341 313067299 CHEMBL3354844 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351081 Fc1ccc(NS(=O)(=O)C2CC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C19H15F2N7O2S/c20-12-5-6-13(28-31(29,30)10-3-4-10)14(21)16(12)27-18-11(2-1-7-22-18)15-17-19(25-8-23-15)26-9-24-17/h1-2,5-10,28H,3-4H2,(H,22,27)(H,23,24,25,26) SMMQTLKZQUWOFV-UHFFFAOYSA-N 197690 US9216981, 19 Serine/threonine-protein kinase B-raf Homo sapiens 250 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197690&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345095 318488807 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351082 Cc1nc(C)c(s1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C21H16F2N8O2S2/c1-10-21(34-11(2)29-10)35(32,33)31-14-6-5-13(22)17(15(14)23)30-19-12(4-3-7-24-19)16-18-20(27-8-25-16)28-9-26-18/h3-9,31H,1-2H3,(H,24,30)(H,25,26,27,28) NRXIQNZUPYHZJU-UHFFFAOYSA-N 197691 US9216981, 20 Serine/threonine-protein kinase B-raf Homo sapiens 700 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197691&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345096 318488808 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351083 Fc1ccc(NS(=O)(=O)N2CCOCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H18F2N8O3S/c21-13-3-4-14(29-34(31,32)30-6-8-33-9-7-30)15(22)17(13)28-19-12(2-1-5-23-19)16-18-20(26-10-24-16)27-11-25-18/h1-5,10-11,29H,6-9H2,(H,23,28)(H,24,25,26,27) PVLBWLQBZCGLQR-UHFFFAOYSA-N 197692 US9216981, 21 Serine/threonine-protein kinase B-raf Homo sapiens 360 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197692&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345097 318488809 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351084 Cn1cnc(c1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H15F2N9O2S/c1-31-7-14(28-10-31)34(32,33)30-13-5-4-12(21)17(15(13)22)29-19-11(3-2-6-23-19)16-18-20(26-8-24-16)27-9-25-18/h2-10,30H,1H3,(H,23,29)(H,24,25,26,27) MGCDELBBUMYCBC-UHFFFAOYSA-N 197693 US9216981, 22 Serine/threonine-protein kinase B-raf Homo sapiens 1000 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197693&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345213 318488810 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351085 Cc1ccc(o1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C21H15F2N7O3S/c1-11-4-7-15(33-11)34(31,32)30-14-6-5-13(22)18(16(14)23)29-20-12(3-2-8-24-20)17-19-21(27-9-25-17)28-10-26-19/h2-10,30H,1H3,(H,24,29)(H,25,26,27,28) QIMUSZMFBWTWNO-UHFFFAOYSA-N 197694 US9216981, 23 Serine/threonine-protein kinase B-raf Homo sapiens 60 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197694&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345214 318488811 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351086 Fc1ccc(NS(=O)(=O)c2occc2C2OCCO2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C23H17F2N7O5S/c24-14-3-4-15(32-38(33,34)23-13(5-7-37-23)22-35-8-9-36-22)16(25)18(14)31-20-12(2-1-6-26-20)17-19-21(29-10-27-17)30-11-28-19/h1-7,10-11,22,32H,8-9H2,(H,26,31)(H,27,28,29,30) FSKBDHVRFZLKSB-UHFFFAOYSA-N 197695 US9216981, 24 Serine/threonine-protein kinase B-raf Homo sapiens 800 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197695&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345215 318488812 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351087 Cc1cc(c(C)o1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H17F2N7O3S/c1-11-8-16(12(2)34-11)35(32,33)31-15-6-5-14(23)19(17(15)24)30-21-13(4-3-7-25-21)18-20-22(28-9-26-18)29-10-27-20/h3-10,31H,1-2H3,(H,25,30)(H,26,27,28,29) MOZZMHNKOZULQL-UHFFFAOYSA-N 197696 US9216981, 25 Serine/threonine-protein kinase B-raf Homo sapiens 100 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197696&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345216 318488813 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351088 Cc1cc(c(o1)C(F)(F)F)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H14F5N7O3S/c1-10-7-14(19(37-10)22(25,26)27)38(35,36)34-13-5-4-12(23)17(15(13)24)33-20-11(3-2-6-28-20)16-18-21(31-8-29-16)32-9-30-18/h2-9,34H,1H3,(H,28,33)(H,29,30,31,32) AAADXMXYZRUUBD-UHFFFAOYSA-N 197697 US9216981, 26 Serine/threonine-protein kinase B-raf Homo sapiens 330 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197697&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345217 318488814 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351089 Cc1cccc(Cl)c1S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C23H16ClF2N7O2S/c1-12-4-2-6-14(24)21(12)36(34,35)33-16-8-7-15(25)19(17(16)26)32-22-13(5-3-9-27-22)18-20-23(30-10-28-18)31-11-29-20/h2-11,33H,1H3,(H,27,32)(H,28,29,30,31) TVQBTBGIQXUFKX-UHFFFAOYSA-N 197698 US9216981, 27 Serine/threonine-protein kinase B-raf Homo sapiens 760 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197698&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345325 318488815 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351090 Fc1ccc(cc1Cl)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H13ClF3N7O2S/c23-13-8-11(3-4-14(13)24)36(34,35)33-16-6-5-15(25)19(17(16)26)32-21-12(2-1-7-27-21)18-20-22(30-9-28-18)31-10-29-20/h1-10,33H,(H,27,32)(H,28,29,30,31) SCRNCGHMVGMPTI-UHFFFAOYSA-N 197699 US9216981, 28 Serine/threonine-protein kinase B-raf Homo sapiens 1930 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197699&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345326 318488816 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351091 Fc1ccc(NS(=O)(=O)c2cccc(Cl)c2F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H13ClF3N7O2S/c23-12-4-1-5-15(16(12)25)36(34,35)33-14-7-6-13(24)19(17(14)26)32-21-11(3-2-8-27-21)18-20-22(30-9-28-18)31-10-29-20/h1-10,33H,(H,27,32)(H,28,29,30,31) PXGZTGOCMAAVGO-UHFFFAOYSA-N 197700 US9216981, 29 Serine/threonine-protein kinase B-raf Homo sapiens 720 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197700&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345327 318488817 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351092 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H14F2N8O2S/c22-14-5-6-15(31-34(32,33)12-3-1-7-24-9-12)16(23)18(14)30-20-13(4-2-8-25-20)17-19-21(28-10-26-17)29-11-27-19/h1-11,31H,(H,25,30)(H,26,27,28,29) JTESGLUEGOKQOX-UHFFFAOYSA-N 197701 US9216981, 30 Serine/threonine-protein kinase B-raf Homo sapiens 70 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197701&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345328 318488818 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351093 Cc1ccccc1S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C23H17F2N7O2S/c1-13-5-2-3-7-17(13)35(33,34)32-16-9-8-15(24)20(18(16)25)31-22-14(6-4-10-26-22)19-21-23(29-11-27-19)30-12-28-21/h2-12,32H,1H3,(H,26,31)(H,27,28,29,30) YREQTIVVMCLZJB-UHFFFAOYSA-N 197702 US9216981, 31 Serine/threonine-protein kinase B-raf Homo sapiens 670 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197702&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345329 318488819 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351094 Fc1ccc(NS(=O)(=O)c2ccccc2Cl)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H14ClF2N7O2S/c23-13-5-1-2-6-16(13)35(33,34)32-15-8-7-14(24)19(17(15)25)31-21-12(4-3-9-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) FJDHTUKBHFXBLS-UHFFFAOYSA-N 197703 US9216981, 32 Serine/threonine-protein kinase B-raf Homo sapiens 440 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197703&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343764 318488820 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351095 Fc1ccc(NS(=O)(=O)c2cccc(Cl)c2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H14ClF2N7O2S/c23-12-3-1-4-13(9-12)35(33,34)32-16-7-6-15(24)19(17(16)25)31-21-14(5-2-8-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) TUORYODHIROMIM-UHFFFAOYSA-N 197704 US9216981, 33 Serine/threonine-protein kinase B-raf Homo sapiens 770 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197704&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343974 318488821 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351096 Fc1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H13Cl2F2N7O2S/c23-12-4-1-5-15(16(12)24)36(34,35)33-14-7-6-13(25)19(17(14)26)32-21-11(3-2-8-27-21)18-20-22(30-9-28-18)31-10-29-20/h1-10,33H,(H,27,32)(H,28,29,30,31) OXDIFBAVMNZPAH-UHFFFAOYSA-N 197705 US9216981, 34 Serine/threonine-protein kinase B-raf Homo sapiens 500 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197705&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343765 318488822 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351097 Fc1ccc(NS(=O)(=O)c2ccccc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H15F2N7O2S/c23-15-8-9-16(31-34(32,33)13-5-2-1-3-6-13)17(24)19(15)30-21-14(7-4-10-25-21)18-20-22(28-11-26-18)29-12-27-20/h1-12,31H,(H,25,30)(H,26,27,28,29) UHPAFPKCOMSYMO-UHFFFAOYSA-N 197706 US9216981, 35::US9550781, 15 Serine/threonine-protein kinase B-raf Homo sapiens 160 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197706&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343766 318488823 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351098 Fc1ccc(NS(=O)(=O)c2cccc3CCOc23)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C24H17F2N7O3S/c25-15-6-7-16(33-37(34,35)17-5-1-3-13-8-10-36-22(13)17)18(26)20(15)32-23-14(4-2-9-27-23)19-21-24(30-11-28-19)31-12-29-21/h1-7,9,11-12,33H,8,10H2,(H,27,32)(H,28,29,30,31) HQLSNMHUQKMLRG-UHFFFAOYSA-N 197707 US9216981, 36 Serine/threonine-protein kinase B-raf Homo sapiens 8370 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197707&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343767 318488824 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351099 Fc1ccc(NS(=O)(=O)c2cccc3ccoc23)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C24H15F2N7O3S/c25-15-6-7-16(33-37(34,35)17-5-1-3-13-8-10-36-22(13)17)18(26)20(15)32-23-14(4-2-9-27-23)19-21-24(30-11-28-19)31-12-29-21/h1-12,33H,(H,27,32)(H,28,29,30,31) SPWVDJAZRHNFJA-UHFFFAOYSA-N 197708 US9216981, 37 Serine/threonine-protein kinase B-raf Homo sapiens 810 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197708&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343768 318488825 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351100 Fc1ccc(NS(=O)(=O)c2cccc3CCCOc23)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C25H19F2N7O3S/c26-16-8-9-17(34-38(35,36)18-7-1-4-14-5-3-11-37-23(14)18)19(27)21(16)33-24-15(6-2-10-28-24)20-22-25(31-12-29-20)32-13-30-22/h1-2,4,6-10,12-13,34H,3,5,11H2,(H,28,33)(H,29,30,31,32) BZIPSTPBTUOWRZ-UHFFFAOYSA-N 197709 US9216981, 38 Serine/threonine-protein kinase B-raf Homo sapiens 7190 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197709&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343867 318488826 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351101 Cc1nc2ccc(cc2s1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C24H16F2N8O2S2/c1-12-32-16-6-4-13(9-18(16)37-12)38(35,36)34-17-7-5-15(25)21(19(17)26)33-23-14(3-2-8-27-23)20-22-24(30-10-28-20)31-11-29-22/h2-11,34H,1H3,(H,27,33)(H,28,29,30,31) JPSGNCLLQOXYGW-UHFFFAOYSA-N 197710 US9216981, 39 Serine/threonine-protein kinase B-raf Homo sapiens 2930 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197710&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343868 318488827 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351102 Cn1ccc2cc(ccc12)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C25H18F2N8O2S/c1-35-10-8-14-11-15(4-7-19(14)35)38(36,37)34-18-6-5-17(26)22(20(18)27)33-24-16(3-2-9-28-24)21-23-25(31-12-29-21)32-13-30-23/h2-13,34H,1H3,(H,28,33)(H,29,30,31,32) IBBWOWZXOLJUHZ-UHFFFAOYSA-N 197711 US9216981, 40 Serine/threonine-protein kinase B-raf Homo sapiens >15000 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197711&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343869 318488828 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351103 Cn1ccc2c(cccc12)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C25H18F2N8O2S/c1-35-11-9-14-18(35)5-2-6-19(14)38(36,37)34-17-8-7-16(26)22(20(17)27)33-24-15(4-3-10-28-24)21-23-25(31-12-29-21)32-13-30-23/h2-13,34H,1H3,(H,28,33)(H,29,30,31,32) SPARSQURLAWSDS-UHFFFAOYSA-N 197712 US9216981, 41 Serine/threonine-protein kinase B-raf Homo sapiens 4200 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197712&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343870 318488829 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351104 Cn1ccc2cccc(c12)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C25H18F2N8O2S/c1-35-11-9-14-4-2-6-18(23(14)35)38(36,37)34-17-8-7-16(26)21(19(17)27)33-24-15(5-3-10-28-24)20-22-25(31-12-29-20)32-13-30-22/h2-13,34H,1H3,(H,28,33)(H,29,30,31,32) PLBMBARKUQBUQN-UHFFFAOYSA-N 197713 US9216981, 42 Serine/threonine-protein kinase B-raf Homo sapiens 5870 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197713&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343871 318488830 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351105 Cn1cc(cn1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H15F2N9O2S/c1-31-8-11(7-28-31)34(32,33)30-14-5-4-13(21)17(15(14)22)29-19-12(3-2-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h2-10,30H,1H3,(H,23,29)(H,24,25,26,27) MFGDWGYOUFSTFA-UHFFFAOYSA-N 197714 US9216981, 43 Serine/threonine-protein kinase B-raf Homo sapiens 1370 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197714&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343972 318488831 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 351106 Fc1ccc(NS(=O)(=O)c2ccc(Cl)s2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H12ClF2N7O2S2/c21-13-5-6-14(33-13)34(31,32)30-12-4-3-11(22)17(15(12)23)29-19-10(2-1-7-24-19)16-18-20(27-8-25-16)28-9-26-18/h1-9,30H,(H,24,29)(H,25,26,27,28) GNIBUZPNXORXMI-UHFFFAOYSA-N 197715 US9216981, 44 Serine/threonine-protein kinase B-raf Homo sapiens 200 37.00 C US Patent 10.7270/Q2BC3XCR aid1802042 US9216981 Shim, EK; Kim, ND; Shim, TB; Kim, SY Medpacto, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197715&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343973 318488832 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359497 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(ncn1)N1CCOCC1 InChI=1S/C23H21F3N4O2/c1-15-5-6-18(29-22(31)16-3-2-4-17(11-16)23(24,25)26)12-19(15)20-13-21(28-14-27-20)30-7-9-32-10-8-30/h2-6,11-14H,7-10H2,1H3,(H,29,31) RZBDOVUMWNDQMO-UHFFFAOYSA-N 202656 US10245267, Example 1::US10709712, Example 1::US9242969, 1::US9694016, 1 Serine/threonine-protein kinase B-raf Homo sapiens 0.408 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202656&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 78325057 319495700 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359498 Cc1ccc(NC(=O)c2ccnc(c2)C(C)(C)C#N)cc1-c1cc(ncn1)N1CCOCC1 InChI=1S/C25H26N6O2/c1-17-4-5-19(30-24(32)18-6-7-27-22(12-18)25(2,3)15-26)13-20(17)21-14-23(29-16-28-21)31-8-10-33-11-9-31/h4-7,12-14,16H,8-11H2,1-3H3,(H,30,32) FYGPVPWZKUOBTA-UHFFFAOYSA-N 202657 US10709712, Example 2::US9242969, 2::US9694016, 2 Serine/threonine-protein kinase B-raf Homo sapiens 6.271 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202657&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297885 319495701 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359499 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1=O InChI=1S/C27H26F3N5O4/c1-17-5-6-20(31-25(37)18-3-2-4-19(13-18)27(28,29)30)14-21(17)22-15-23(35-9-12-39-16-24(35)36)33-26(32-22)34-7-10-38-11-8-34/h2-6,13-15H,7-12,16H2,1H3,(H,31,37) VWZRDTLPMXJTFJ-UHFFFAOYSA-N 202658 US10245267, Example 3::US10709712, Example 3::US9242969, 3::US9694016, 3 Serine/threonine-protein kinase B-raf Homo sapiens 0.51 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202658&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86298086 319495702 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359500 Cc1ccc(cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1=O)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C27H26F3N5O4/c1-17-5-6-18(25(37)31-20-4-2-3-19(14-20)27(28,29)30)13-21(17)22-15-23(35-9-12-39-16-24(35)36)33-26(32-22)34-7-10-38-11-8-34/h2-6,13-15H,7-12,16H2,1H3,(H,31,37) FCNIJEGJNGSXDC-UHFFFAOYSA-N 202659 US10245267, Example 4::US10709712, Example 4::US9242969, 4::US9694016, 4 Serine/threonine-protein kinase B-raf Homo sapiens 1.332 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202659&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86298087 319495703 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359501 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1=O InChI=1S/C26H25F3N6O4/c1-16-20(12-19(14-30-16)31-24(37)17-3-2-4-18(11-17)26(27,28)29)21-13-22(35-7-10-39-15-23(35)36)33-25(32-21)34-5-8-38-9-6-34/h2-4,11-14H,5-10,15H2,1H3,(H,31,37) PTVOALIUHBHIKV-UHFFFAOYSA-N 202660 US10709712, Example 5::US9242969, 5::US9694016, 5 Serine/threonine-protein kinase B-raf Homo sapiens 2.996 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202660&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442593 319495704 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359502 Cc1ccc(cc1-c1cc(nc(n1)N1CCOCC1)N1CCS(=O)(=O)CC1)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C27H28F3N5O4S/c1-18-5-6-19(25(36)31-21-4-2-3-20(16-21)27(28,29)30)15-22(18)23-17-24(34-9-13-40(37,38)14-10-34)33-26(32-23)35-7-11-39-12-8-35/h2-6,15-17H,7-14H2,1H3,(H,31,36) CJQHHPNKIQNPAX-UHFFFAOYSA-N 202662 US10245267, Example 7::US10709712, Example 7::US9242969, 7::US9694016, 7 Serine/threonine-protein kinase B-raf Homo sapiens 3.146 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202662&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86298088 319495706 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359503 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCS(=O)(=O)CC1)N1CCOCC1 InChI=1S/C27H28F3N5O4S/c1-18-5-6-21(31-25(36)19-3-2-4-20(15-19)27(28,29)30)16-22(18)23-17-24(34-7-11-39-12-8-34)33-26(32-23)35-9-13-40(37,38)14-10-35/h2-6,15-17H,7-14H2,1H3,(H,31,36) POLYTOCMNSPOHH-UHFFFAOYSA-N 202663 US10709712, Example 8::US9242969, 8::US9242969, 9::US9694016, 8 Serine/threonine-protein kinase B-raf Homo sapiens 0.837 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202663&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86298090 319495707 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359504 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCS(=O)(=O)CC1)N1CCOCC1 InChI=1S/C27H28F3N5O4S/c1-18-5-6-21(31-25(36)19-3-2-4-20(15-19)27(28,29)30)16-22(18)23-17-24(34-7-11-39-12-8-34)33-26(32-23)35-9-13-40(37,38)14-10-35/h2-6,15-17H,7-14H2,1H3,(H,31,36) POLYTOCMNSPOHH-UHFFFAOYSA-N 202663 US10709712, Example 8::US9242969, 8::US9242969, 9::US9694016, 8 Serine/threonine-protein kinase B-raf Homo sapiens 1.587 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202663&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86298090 319495707 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359505 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1 InChI=1S/C27H28F3N5O3/c1-18-5-6-21(31-25(36)19-3-2-4-20(15-19)27(28,29)30)16-22(18)23-17-24(34-7-11-37-12-8-34)33-26(32-23)35-9-13-38-14-10-35/h2-6,15-17H,7-14H2,1H3,(H,31,36) ZHNCJARBTUXWNB-UHFFFAOYSA-N 202665 US10245267, Example 10::US10709712, Example 10::US9242969, 10::US9694016, 10 Serine/threonine-protein kinase B-raf Homo sapiens 0.33 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202665&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86298297 319495708 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359506 Cc1ccc(cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C27H28F3N5O3/c1-18-5-6-19(25(36)31-21-4-2-3-20(16-21)27(28,29)30)15-22(18)23-17-24(34-7-11-37-12-8-34)33-26(32-23)35-9-13-38-14-10-35/h2-6,15-17H,7-14H2,1H3,(H,31,36) ZNVCVMODGVQVMO-UHFFFAOYSA-N 202666 US10245267, Example 11::US10709712, Example 11::US9242969, 11::US9694016, 11 Serine/threonine-protein kinase B-raf Homo sapiens 1.481 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202666&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86298298 319495709 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359507 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1 InChI=1S/C26H27F3N6O3/c1-17-21(14-20(16-30-17)31-24(36)18-3-2-4-19(13-18)26(27,28)29)22-15-23(34-5-9-37-10-6-34)33-25(32-22)35-7-11-38-12-8-35/h2-4,13-16H,5-12H2,1H3,(H,31,36) VCRWYFQGTCFZDJ-UHFFFAOYSA-N 202667 US10245267, Example 12::US10709712, Example 12::US9242969, 12::US9694016, 12 Serine/threonine-protein kinase B-raf Homo sapiens 1.82 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202667&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86298300 319495710 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359508 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1nc(cc(n1)N1CCOCC1)N1CCOCC1 InChI=1S/C27H28F3N5O3/c1-18-5-6-21(31-26(36)19-3-2-4-20(15-19)27(28,29)30)16-22(18)25-32-23(34-7-11-37-12-8-34)17-24(33-25)35-9-13-38-14-10-35/h2-6,15-17H,7-14H2,1H3,(H,31,36) HMDOKKUHHDRRAK-UHFFFAOYSA-N 202668 US10245267, Example 13::US10709712, Example 13::US9242969, 13::US9694016, 13 Serine/threonine-protein kinase B-raf Homo sapiens 2.168 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202668&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86298299 319495711 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359509 Cc1ccc(cc1-c1nc(cc(n1)N1CCOCC1)N1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C27H28F3N5O3/c1-18-5-6-19(26(36)31-21-4-2-3-20(16-21)27(28,29)30)15-22(18)25-32-23(34-7-11-37-12-8-34)17-24(33-25)35-9-13-38-14-10-35/h2-6,15-17H,7-14H2,1H3,(H,31,36) HKDMNDSYJYCJAJ-UHFFFAOYSA-N 202669 US10245267, Example 14::US10709712, Example 14::US9242969, 14::US9694016, 14 Serine/threonine-protein kinase B-raf Homo sapiens 2.007 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202669&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86298301 319495712 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359510 Cc1ccc(NC(=O)c2ccnc(c2)C(C)(C)C#N)cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1 InChI=1S/C29H33N7O3/c1-20-4-5-22(32-27(37)21-6-7-31-25(16-21)29(2,3)19-30)17-23(20)24-18-26(35-8-12-38-13-9-35)34-28(33-24)36-10-14-39-15-11-36/h4-7,16-18H,8-15H2,1-3H3,(H,32,37) DGSFEEKRYOVQNO-UHFFFAOYSA-N 202670 US10245267, Example 15::US10709712, Example 15::US9242969, 15::US9694016, 15 Serine/threonine-protein kinase B-raf Homo sapiens 2.224 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202670&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295249 319495713 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359511 Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1 InChI=1S/C30H34N6O3/c1-21-7-8-24(32-28(37)22-5-4-6-23(17-22)30(2,3)20-31)18-25(21)26-19-27(35-9-13-38-14-10-35)34-29(33-26)36-11-15-39-16-12-36/h4-8,17-19H,9-16H2,1-3H3,(H,32,37) FEJAQUKVYQVYED-UHFFFAOYSA-N 202671 US10245267, Example 16::US10709712, Example 16::US9242969, 16::US9694016, 16 Serine/threonine-protein kinase B-raf Homo sapiens 1.521 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202671&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295250 319495714 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359512 Cc1ccc(NC(=O)c2cccc(c2Cl)C2(CC2)C#N)cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1 InChI=1S/C30H31ClN6O3/c1-20-5-6-21(33-28(38)22-3-2-4-24(27(22)31)30(19-32)7-8-30)17-23(20)25-18-26(36-9-13-39-14-10-36)35-29(34-25)37-11-15-40-16-12-37/h2-6,17-18H,7-16H2,1H3,(H,33,38) XCXFXWRKFZQEPQ-UHFFFAOYSA-N 202672 US10245267, Example 17::US10709712, Example 17::US9242969, 17::US9694016, 17 Serine/threonine-protein kinase B-raf Homo sapiens 3.05 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202672&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442597 319495715 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359513 CN(C)c1cncc(c1)C(=O)Nc1ccc(C)c(c1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1 InChI=1S/C27H33N7O3/c1-19-4-5-21(29-26(35)20-14-22(32(2)3)18-28-17-20)15-23(19)24-16-25(33-6-10-36-11-7-33)31-27(30-24)34-8-12-37-13-9-34/h4-5,14-18H,6-13H2,1-3H3,(H,29,35) GIFXXPXSCMJGGJ-UHFFFAOYSA-N 202673 US10245267, Example 18::US10709712, Example 18::US9242969, 18::US9694016, 18 Serine/threonine-protein kinase B-raf Homo sapiens 0.456 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295251 319495716 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359514 Cc1ccc(NC(=O)c2cncc(c2)C(C)(C)C)cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1 InChI=1S/C29H36N6O3/c1-20-5-6-23(31-27(36)21-15-22(19-30-18-21)29(2,3)4)16-24(20)25-17-26(34-7-11-37-12-8-34)33-28(32-25)35-9-13-38-14-10-35/h5-6,15-19H,7-14H2,1-4H3,(H,31,36) LDTUEQNAYCVAAO-UHFFFAOYSA-N 202674 US9242969, 19 Serine/threonine-protein kinase B-raf Homo sapiens 1.851 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202674&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295252 319495717 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359515 CN(C)Cc1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(c1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1 InChI=1S/C30H35F3N6O3/c1-20-4-5-24(34-28(40)22-14-21(19-37(2)3)15-23(16-22)30(31,32)33)17-25(20)26-18-27(38-6-10-41-11-7-38)36-29(35-26)39-8-12-42-13-9-39/h4-5,14-18H,6-13,19H2,1-3H3,(H,34,40) AIPRPSWGJJAMMI-UHFFFAOYSA-N 202675 US10245267, Example 20::US10709712, Example 20::US9242969, 20::US9694016, 20 Serine/threonine-protein kinase B-raf Homo sapiens 1.967 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202675&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442598 319495718 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359516 CCN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(c1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1 InChI=1S/C33H40F3N7O3/c1-3-40-6-8-41(9-7-40)27-19-24(18-25(20-27)33(34,35)36)31(44)37-26-5-4-23(2)28(21-26)29-22-30(42-10-14-45-15-11-42)39-32(38-29)43-12-16-46-17-13-43/h4-5,18-22H,3,6-17H2,1-2H3,(H,37,44) XODKNGBNTMFKRE-UHFFFAOYSA-N 202676 US10245267, Example 21::US10709712, Example 21::US9242969, 21::US9694016, 21 Serine/threonine-protein kinase B-raf Homo sapiens 3.433 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202676&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295253 319495719 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359517 Cc1ccc(NC(=O)c2cccc(OC(F)(F)F)c2)cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1 InChI=1S/C27H28F3N5O4/c1-18-5-6-20(31-25(36)19-3-2-4-21(15-19)39-27(28,29)30)16-22(18)23-17-24(34-7-11-37-12-8-34)33-26(32-23)35-9-13-38-14-10-35/h2-6,15-17H,7-14H2,1H3,(H,31,36) ZPMMEQLJGQJSKJ-UHFFFAOYSA-N 202677 US10245267, Example 22::US10709712, Example 22::US9242969, 22::US9694016, 22 Serine/threonine-protein kinase B-raf Homo sapiens 0.652 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202677&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442599 319495720 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359518 Cc1ccc(NC(=O)c2cccc(c2)S(C)(=O)=O)cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1 InChI=1S/C27H31N5O5S/c1-19-6-7-21(28-26(33)20-4-3-5-22(16-20)38(2,34)35)17-23(19)24-18-25(31-8-12-36-13-9-31)30-27(29-24)32-10-14-37-15-11-32/h3-7,16-18H,8-15H2,1-2H3,(H,28,33) XXJULQHALWBMRS-UHFFFAOYSA-N 202678 US10245267, Example 23::US10709712, Example 23::US9242969, 23::US9694016, 23 Serine/threonine-protein kinase B-raf Homo sapiens 2.416 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202678&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295454 319495721 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359519 Cc1ccc(NC(=O)c2cc(no2)C(C)(C)C)cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1 InChI=1S/C27H34N6O4/c1-18-5-6-19(28-25(34)22-17-23(31-37-22)27(2,3)4)15-20(18)21-16-24(32-7-11-35-12-8-32)30-26(29-21)33-9-13-36-14-10-33/h5-6,15-17H,7-14H2,1-4H3,(H,28,34) PNGGYMKHJMOIPI-UHFFFAOYSA-N 202679 US10245267, Example 24::US10709712, Example 24::US9242969, 24::US9694016, 24 Serine/threonine-protein kinase B-raf Homo sapiens 1.356 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202679&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295456 319495722 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359520 Cc1ccc(NC(=O)c2cc(on2)C(C)(C)C)cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1 InChI=1S/C27H34N6O4/c1-18-5-6-19(28-25(34)22-16-23(37-31-22)27(2,3)4)15-20(18)21-17-24(32-7-11-35-12-8-32)30-26(29-21)33-9-13-36-14-10-33/h5-6,15-17H,7-14H2,1-4H3,(H,28,34) URECZFRBORHDEQ-UHFFFAOYSA-N 202680 US10245267, Example 25::US10709712, Example 25::US9242969, 25::US9694016, 25 Serine/threonine-protein kinase B-raf Homo sapiens 1.197 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202680&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295455 319495723 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359521 Cc1ccc(NC(=O)c2csc(n2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1 InChI=1S/C24H25F3N6O3S/c1-15-2-3-16(28-21(34)19-14-37-22(29-19)24(25,26)27)12-17(15)18-13-20(32-4-8-35-9-5-32)31-23(30-18)33-6-10-36-11-7-33/h2-3,12-14H,4-11H2,1H3,(H,28,34) RVPQVKRCGLMTMT-UHFFFAOYSA-N 202681 US10245267, Example 26::US10709712, Example 26::US9242969, 26::US9694016, 26 Serine/threonine-protein kinase B-raf Homo sapiens 2.177 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202681&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295457 319495724 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359522 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)S(C)(=O)=O)N1CCOCC1 InChI=1S/C24H23F3N4O4S/c1-15-6-7-18(28-22(32)16-4-3-5-17(12-16)24(25,26)27)13-19(15)20-14-21(31-8-10-35-11-9-31)30-23(29-20)36(2,33)34/h3-7,12-14H,8-11H2,1-2H3,(H,28,32) BDMRXFODCGLAFM-UHFFFAOYSA-N 202682 US10245267, Example 38::US10709712, Example 38::US9242969, 27::US9694016, 27 Serine/threonine-protein kinase B-raf Homo sapiens 0.86 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202682&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409101 319495725 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359523 CCNc1nc(cc(n1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C)N1CCOCC1 InChI=1S/C25H26F3N5O2/c1-3-29-24-31-21(15-22(32-24)33-9-11-35-12-10-33)20-14-19(8-7-16(20)2)30-23(34)17-5-4-6-18(13-17)25(26,27)28/h4-8,13-15H,3,9-12H2,1-2H3,(H,30,34)(H,29,31,32) RXSOMFNCTBYYMX-UHFFFAOYSA-N 202683 US9242969, 28::US9694016, 28 Serine/threonine-protein kinase B-raf Homo sapiens 0.585 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202683&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295458 319495726 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359524 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CC2(COC2)C1)N1CCOCC1 InChI=1S/C28H28F3N5O3/c1-18-5-6-21(32-25(37)19-3-2-4-20(11-19)28(29,30)31)12-22(18)23-13-24(35-7-9-38-10-8-35)34-26(33-23)36-14-27(15-36)16-39-17-27/h2-6,11-13H,7-10,14-17H2,1H3,(H,32,37) NHIDIWOUTDGPHN-UHFFFAOYSA-N 202684 US10245267, Example 29::US10709712, Example 29::US9242969, 29::US9694016, 29 Serine/threonine-protein kinase B-raf Homo sapiens 1.306 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202684&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295665 319495727 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359525 CNc1nc(cc(n1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C)N1CCOCC1 InChI=1S/C24H24F3N5O2/c1-15-6-7-18(29-22(33)16-4-3-5-17(12-16)24(25,26)27)13-19(15)20-14-21(31-23(28-2)30-20)32-8-10-34-11-9-32/h3-7,12-14H,8-11H2,1-2H3,(H,29,33)(H,28,30,31) TYRBFDFCWLLXCF-UHFFFAOYSA-N 202685 US10245267, Example 30::US10709712, Example 30::US9242969, 30::US9694016, 30 Serine/threonine-protein kinase B-raf Homo sapiens 0.83 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202685&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295667 319495728 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359526 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(NCCO)n1)N1CCOCC1 InChI=1S/C25H26F3N5O3/c1-16-5-6-19(30-23(35)17-3-2-4-18(13-17)25(26,27)28)14-20(16)21-15-22(33-8-11-36-12-9-33)32-24(31-21)29-7-10-34/h2-6,13-15,34H,7-12H2,1H3,(H,30,35)(H,29,31,32) GZEIUQBPVOBYNA-UHFFFAOYSA-N 202686 US10245267, Example 31::US10709712, Example 31::US9242969, 31::US9694016, 31 Serine/threonine-protein kinase B-raf Homo sapiens 0.737 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202686&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295666 319495729 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359527 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCC(O)C1)N1CCOCC1 InChI=1S/C27H28F3N5O3/c1-17-5-6-20(31-25(37)18-3-2-4-19(13-18)27(28,29)30)14-22(17)23-15-24(34-9-11-38-12-10-34)33-26(32-23)35-8-7-21(36)16-35/h2-6,13-15,21,36H,7-12,16H2,1H3,(H,31,37) UFJILEUJRRXOHJ-UHFFFAOYSA-N 202687 US10245267, Example 32::US10709712, Example 32::US9242969, 32::US9694016, 32 Serine/threonine-protein kinase B-raf Homo sapiens 1.695 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202687&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295668 319495730 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359528 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)-n1ccnc1)N1CCOCC1 InChI=1S/C26H23F3N6O2/c1-17-5-6-20(31-24(36)18-3-2-4-19(13-18)26(27,28)29)14-21(17)22-15-23(34-9-11-37-12-10-34)33-25(32-22)35-8-7-30-16-35/h2-8,13-16H,9-12H2,1H3,(H,31,36) ZAYWARVMFZWGAP-UHFFFAOYSA-N 202688 US10245267, Example 33::US10709712, Example 33::US9242969, 33::US9694016, 33 Serine/threonine-protein kinase B-raf Homo sapiens 0.455 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202688&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295669 319495731 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359529 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(OCCO)n1)N1CCOCC1 InChI=1S/C24H24F3N5O4/c1-15-19(20-13-21(32-5-8-35-9-6-32)31-23(30-20)36-10-7-33)12-18(14-28-15)29-22(34)16-3-2-4-17(11-16)24(25,26)27/h2-4,11-14,33H,5-10H2,1H3,(H,29,34) FFJPMZAIZAHGTD-UHFFFAOYSA-N 202689 US9242969, 34 Serine/threonine-protein kinase B-raf Homo sapiens 1.853 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202689&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442611 319495732 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359530 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(NS(C)(=O)=O)n1)N1CCOCC1 InChI=1S/C24H24F3N5O4S/c1-15-6-7-18(28-22(33)16-4-3-5-17(12-16)24(25,26)27)13-19(15)20-14-21(32-8-10-36-11-9-32)30-23(29-20)31-37(2,34)35/h3-7,12-14H,8-11H2,1-2H3,(H,28,33)(H,29,30,31) CWPVMCLRIZDTFY-UHFFFAOYSA-N 202690 US10245267, Example 35::US10709712, Example 35::US9242969, 35::US9694016, 35 Serine/threonine-protein kinase B-raf Homo sapiens 3.454 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202690&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409413 319495733 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359531 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCCC1=O)N1CCOCC1 InChI=1S/C27H26F3N5O3/c1-17-7-8-20(31-25(37)18-4-2-5-19(14-18)27(28,29)30)15-21(17)22-16-23(34-10-12-38-13-11-34)33-26(32-22)35-9-3-6-24(35)36/h2,4-5,7-8,14-16H,3,6,9-13H2,1H3,(H,31,37) OFHHKPCWLMSMEO-UHFFFAOYSA-N 202691 US10245267, Example 36::US10709712, Example 36::US9242969, 36::US9694016, 36 Serine/threonine-protein kinase B-raf Homo sapiens 1.277 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202691&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295876 319495734 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359532 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)-n1cc(nn1)C(C)(C)O)N1CCOCC1 InChI=1S/C28H28F3N7O3/c1-17-7-8-20(32-25(39)18-5-4-6-19(13-18)28(29,30)31)14-21(17)22-15-24(37-9-11-41-12-10-37)34-26(33-22)38-16-23(35-36-38)27(2,3)40/h4-8,13-16,40H,9-12H2,1-3H3,(H,32,39) YFGBLRZGYKYFOK-UHFFFAOYSA-N 202692 US10245267, Example 37::US10709712, Example 37::US9242969, 37::US9694016, 37 Serine/threonine-protein kinase B-raf Homo sapiens 0.773 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202692&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295875 319495735 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359533 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(N)n1)N1CCOCC1 InChI=1S/C23H22F3N5O2/c1-14-5-6-17(28-21(32)15-3-2-4-16(11-15)23(24,25)26)12-18(14)19-13-20(30-22(27)29-19)31-7-9-33-10-8-31/h2-6,11-13H,7-10H2,1H3,(H,28,32)(H2,27,29,30) DEFBACDLTQLHSG-UHFFFAOYSA-N 202693 US9242969, 38::US9694016, 38 Serine/threonine-protein kinase B-raf Homo sapiens 1.429 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202693&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295877 319495736 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359534 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(NC(CO)CO)n1)N1CCOCC1 InChI=1S/C26H28F3N5O4/c1-16-5-6-19(30-24(37)17-3-2-4-18(11-17)26(27,28)29)12-21(16)22-13-23(34-7-9-38-10-8-34)33-25(32-22)31-20(14-35)15-36/h2-6,11-13,20,35-36H,7-10,14-15H2,1H3,(H,30,37)(H,31,32,33) JCQCZVGYVYKECZ-UHFFFAOYSA-N 202694 US10245267, Example 39::US10709712, Example 39::US9242969, 39::US9694016, 39 Serine/threonine-protein kinase B-raf Homo sapiens 0.816 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202694&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408838 319495737 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359535 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(OCCO)n1)N1CCOCC1 InChI=1S/C25H25F3N4O4/c1-16-5-6-19(29-23(34)17-3-2-4-18(13-17)25(26,27)28)14-20(16)21-15-22(32-7-10-35-11-8-32)31-24(30-21)36-12-9-33/h2-6,13-15,33H,7-12H2,1H3,(H,29,34) VIMSPEXOOOZTHP-UHFFFAOYSA-N 202695 US10245267, Example 40::US10709712, Example 40::US9242969, 40::US9694016, 40 Serine/threonine-protein kinase B-raf Homo sapiens 0.601 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202695&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295874 319495738 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359536 CC(=C)c1cc(nc(n1)N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C InChI=1S/C26H25F3N4O2/c1-16(2)22-15-23(32-25(31-22)33-9-11-35-12-10-33)21-14-20(8-7-17(21)3)30-24(34)18-5-4-6-19(13-18)26(27,28)29/h4-8,13-15H,1,9-12H2,2-3H3,(H,30,34) NZQDZMBWHLVRCS-UHFFFAOYSA-N 202696 US10245267, Example 43::US10709712, Example 42::US9242969, 42::US9694016, 42 Serine/threonine-protein kinase B-raf Homo sapiens 0.422 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202696&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295878 319495739 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359537 CC(=C)c1cc(nc(n1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C)N1CCOCC1 InChI=1S/C26H25F3N4O2/c1-16(2)22-15-23(33-9-11-35-12-10-33)32-24(31-22)21-14-20(8-7-17(21)3)30-25(34)18-5-4-6-19(13-18)26(27,28)29/h4-8,13-15H,1,9-12H2,2-3H3,(H,30,34) OJMHBRGTXHCAEY-UHFFFAOYSA-N 202697 US10245267, Example 42::US10709712, Example 43::US9242969, 43 Serine/threonine-protein kinase B-raf Homo sapiens 1.648 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202697&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296093 319495740 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359538 CC(C)c1cc(nc(n1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C)N1CCOCC1 InChI=1S/C26H27F3N4O2/c1-16(2)22-15-23(33-9-11-35-12-10-33)32-24(31-22)21-14-20(8-7-17(21)3)30-25(34)18-5-4-6-19(13-18)26(27,28)29/h4-8,13-16H,9-12H2,1-3H3,(H,30,34) LKDOTYAMIILGBT-UHFFFAOYSA-N 202698 US10245267, Example 44::US10709712, Example 44::US9242969, 44::US9694016, 44 Serine/threonine-protein kinase B-raf Homo sapiens 2.875 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202698&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296094 319495741 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359539 CC(C)c1cc(nc(n1)N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C InChI=1S/C26H27F3N4O2/c1-16(2)22-15-23(32-25(31-22)33-9-11-35-12-10-33)21-14-20(8-7-17(21)3)30-24(34)18-5-4-6-19(13-18)26(27,28)29/h4-8,13-16H,9-12H2,1-3H3,(H,30,34) IHBLFXPNFUIIDO-UHFFFAOYSA-N 202699 US10245267, Example 45::US10709712, Example 45::US9242969, 45::US9694016, 45 Serine/threonine-protein kinase B-raf Homo sapiens 5.678 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202699&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296095 319495742 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359540 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCOCC1)N1CCOC(C)(C)C1 InChI=1S/C29H32F3N5O3/c1-19-7-8-22(33-26(38)20-5-4-6-21(15-20)29(30,31)32)16-23(19)24-17-25(37-11-14-40-28(2,3)18-37)35-27(34-24)36-9-12-39-13-10-36/h4-8,15-17H,9-14,18H2,1-3H3,(H,33,38) YVIVLTLRRXEVQB-UHFFFAOYSA-N 202700 US10245267, Example 46::US10709712, Example 46::US9242969, 46::US9694016, 46 Serine/threonine-protein kinase B-raf Homo sapiens 2.118 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202700&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296096 319495743 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359541 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCOCC1)N1CC2(COC2)C1 InChI=1S/C28H28F3N5O3/c1-18-5-6-21(32-25(37)19-3-2-4-20(11-19)28(29,30)31)12-22(18)23-13-24(36-14-27(15-36)16-39-17-27)34-26(33-23)35-7-9-38-10-8-35/h2-6,11-13H,7-10,14-17H2,1H3,(H,32,37) JSNUOUDTFPPBCQ-UHFFFAOYSA-N 202701 US10245267, Example 47::US10709712, Example 47::US9242969, 47::US9694016, 47 Serine/threonine-protein kinase B-raf Homo sapiens 2.454 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202701&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296097 319495744 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359542 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCOCC1)N1CCOC[C@H]1CO InChI=1S/C28H30F3N5O4/c1-18-5-6-21(32-26(38)19-3-2-4-20(13-19)28(29,30)31)14-23(18)24-15-25(36-9-12-40-17-22(36)16-37)34-27(33-24)35-7-10-39-11-8-35/h2-6,13-15,22,37H,7-12,16-17H2,1H3,(H,32,38)/t22-/m1/s1 WQOBMKLNZZRYPF-JOCHJYFZSA-N 202702 US10245267, Example 48::US10709712, Example 48::US9242969, 48::US9694016, 48 Serine/threonine-protein kinase B-raf Homo sapiens 1.43 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202702&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296308 319495745 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359543 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCOCC1)N1C2CCC1COC2 InChI=1S/C29H30F3N5O3/c1-18-5-6-21(33-27(38)19-3-2-4-20(13-19)29(30,31)32)14-24(18)25-15-26(37-22-7-8-23(37)17-40-16-22)35-28(34-25)36-9-11-39-12-10-36/h2-6,13-15,22-23H,7-12,16-17H2,1H3,(H,33,38) YJAFXQYRMGBMNV-UHFFFAOYSA-N 202703 US10245267, Example 49::US10709712, Example 49::US9242969, 49::US9694016, 49 Serine/threonine-protein kinase B-raf Homo sapiens 1.495 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202703&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409068 319495746 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359544 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCOCC1)N1CCCOCC1 InChI=1S/C28H30F3N5O3/c1-19-6-7-22(32-26(37)20-4-2-5-21(16-20)28(29,30)31)17-23(19)24-18-25(35-8-3-12-38-13-9-35)34-27(33-24)36-10-14-39-15-11-36/h2,4-7,16-18H,3,8-15H2,1H3,(H,32,37) WQNJLMVKMKGYHJ-UHFFFAOYSA-N 202704 US10245267, Example 50::US10709712, Example 50::US9242969, 50::US9694016, 50 Serine/threonine-protein kinase B-raf Homo sapiens 1.131 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202704&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296309 319495747 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359545 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCOCC1)N1CC2CC1CO2 InChI=1S/C28H28F3N5O3/c1-17-5-6-20(32-26(37)18-3-2-4-19(11-18)28(29,30)31)12-23(17)24-14-25(36-15-22-13-21(36)16-39-22)34-27(33-24)35-7-9-38-10-8-35/h2-6,11-12,14,21-22H,7-10,13,15-16H2,1H3,(H,32,37) IZBMEXQVTDDEFG-UHFFFAOYSA-N 202705 US10245267, Example 51::US10709712, Example 51::US9242969, 51::US9694016, 51 Serine/threonine-protein kinase B-raf Homo sapiens 3.162 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202705&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409470 319495748 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359546 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCOCC1)N1CC2CCC(C1)O2 InChI=1S/C29H30F3N5O3/c1-18-5-6-21(33-27(38)19-3-2-4-20(13-19)29(30,31)32)14-24(18)25-15-26(37-16-22-7-8-23(17-37)40-22)35-28(34-25)36-9-11-39-12-10-36/h2-6,13-15,22-23H,7-12,16-17H2,1H3,(H,33,38) VPFGZMRBOWQVQS-UHFFFAOYSA-N 202706 US10245267, Example 52::US10709712, Example 52::US9242969, 52::US9694016, 52 Serine/threonine-protein kinase B-raf Homo sapiens 0.884 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202706&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409790 319495749 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359547 C[C@@H]1CN(CCO1)c1cc(nc(n1)N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C InChI=1S/C28H30F3N5O3/c1-18-6-7-22(32-26(37)20-4-3-5-21(14-20)28(29,30)31)15-23(18)24-16-25(36-10-13-39-19(2)17-36)34-27(33-24)35-8-11-38-12-9-35/h3-7,14-16,19H,8-13,17H2,1-2H3,(H,32,37)/t19-/m1/s1 COVZIQFEGYGTDK-LJQANCHMSA-N 202707 US10245267, Example 53::US10709712, Example 53::US9242969, 53::US9694016, 53 Serine/threonine-protein kinase B-raf Homo sapiens 2.499 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202707&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296310 319495750 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359548 C[C@H]1CN(CCO1)c1cc(nc(n1)N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C InChI=1S/C28H30F3N5O3/c1-18-6-7-22(32-26(37)20-4-3-5-21(14-20)28(29,30)31)15-23(18)24-16-25(36-10-13-39-19(2)17-36)34-27(33-24)35-8-11-38-12-9-35/h3-7,14-16,19H,8-13,17H2,1-2H3,(H,32,37)/t19-/m0/s1 COVZIQFEGYGTDK-IBGZPJMESA-N 202708 US10245267, Example 54::US10709712, Example 54::US9242969, 54::US9694016, 54 Serine/threonine-protein kinase B-raf Homo sapiens 3.14 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202708&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296311 319495751 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359549 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(OC2CCOCC2)nc(n1)N1CCOCC1 InChI=1S/C28H29F3N4O4/c1-18-5-6-21(32-26(36)19-3-2-4-20(15-19)28(29,30)31)16-23(18)24-17-25(39-22-7-11-37-12-8-22)34-27(33-24)35-9-13-38-14-10-35/h2-6,15-17,22H,7-14H2,1H3,(H,32,36) GQHAIYPRZGYSET-UHFFFAOYSA-N 202710 US10245267, Example 56::US10709712, Example 56::US9242969, 56::US9694016, 56 Serine/threonine-protein kinase B-raf Homo sapiens 1.001 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202710&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296312 319495752 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359550 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1nc(nc(N2CCOCC2)c1C)N1CCOCC1 InChI=1S/C28H30F3N5O3/c1-18-6-7-22(32-26(37)20-4-3-5-21(16-20)28(29,30)31)17-23(18)24-19(2)25(35-8-12-38-13-9-35)34-27(33-24)36-10-14-39-15-11-36/h3-7,16-17H,8-15H2,1-2H3,(H,32,37) BVIRREIIKKWRDP-UHFFFAOYSA-N 202711 US10245267, Example 57::US10709712, Example 57::US9242969, 57::US9694016, 57 Serine/threonine-protein kinase B-raf Homo sapiens 0.994 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202711&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296506 319495753 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359551 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cnnc(c1)N1CCOCC1 InChI=1S/C22H20F3N5O2/c1-14-19(16-10-20(29-27-12-16)30-5-7-32-8-6-30)11-18(13-26-14)28-21(31)15-3-2-4-17(9-15)22(23,24)25/h2-4,9-13H,5-8H2,1H3,(H,28,31) HMYPLUBRLSAURN-UHFFFAOYSA-N 202712 US10245267, Example 58::US10709712, Example 58::US9242969, 58::US9694016, 58 Serine/threonine-protein kinase B-raf Homo sapiens 8.715 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202712&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296507 319495754 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359552 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(cnn1)N1CCOCC1 InChI=1S/C23H21F3N4O2/c1-15-5-6-18(28-22(31)16-3-2-4-17(11-16)23(24,25)26)12-20(15)21-13-19(14-27-29-21)30-7-9-32-10-8-30/h2-6,11-14H,7-10H2,1H3,(H,28,31) QCEVVVDVWXYHGN-UHFFFAOYSA-N 202713 US10245267, Example 59::US10709712, Example 59::US9242969, 59::US9694016, 59 Serine/threonine-protein kinase B-raf Homo sapiens 2.655 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202713&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296508 319495755 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359553 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(cnn1)N1CCOCC1 InChI=1S/C22H20F3N5O2/c1-14-19(20-11-18(13-27-29-20)30-5-7-32-8-6-30)10-17(12-26-14)28-21(31)15-3-2-4-16(9-15)22(23,24)25/h2-4,9-13H,5-8H2,1H3,(H,28,31) CHLVIYONHNDXJY-UHFFFAOYSA-N 202714 US10245267, Example 60::US10709712, Example 60::US9242969, 60::US9694016, 60 Serine/threonine-protein kinase B-raf Homo sapiens 6.966 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202714&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296509 319495756 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359554 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCOCC1)C(F)(F)F InChI=1S/C24H20F6N4O2/c1-14-5-6-17(31-21(35)15-3-2-4-16(11-15)23(25,26)27)12-18(14)19-13-20(24(28,29)30)33-22(32-19)34-7-9-36-10-8-34/h2-6,11-13H,7-10H2,1H3,(H,31,35) OSOVXTBDOUWVIM-UHFFFAOYSA-N 202715 US10245267, Example 61::US10709712, Example 61::US9242969, 61::US9694016, 61 Serine/threonine-protein kinase B-raf Homo sapiens 2.273 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202715&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296510 319495757 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359555 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C24H22F3N3O2/c1-16-5-6-20(29-23(31)18-3-2-4-19(13-18)24(25,26)27)15-21(16)17-7-8-28-22(14-17)30-9-11-32-12-10-30/h2-8,13-15H,9-12H2,1H3,(H,29,31) NOPNJPVZJCPTKV-UHFFFAOYSA-N 202716 US10245267, Example 62::US10709712, Example 62::US9242969, 62::US9694016, 62 Serine/threonine-protein kinase B-raf Homo sapiens 1.08 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202716&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296699 319495758 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359556 Cc1ccc(cc1-c1ccnc(c1)N1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C24H22F3N3O2/c1-16-5-6-18(23(31)29-20-4-2-3-19(15-20)24(25,26)27)13-21(16)17-7-8-28-22(14-17)30-9-11-32-12-10-30/h2-8,13-15H,9-12H2,1H3,(H,29,31) LZHLFLLBTSFGEX-UHFFFAOYSA-N 202717 US10245267, Example 63::US10709712, Example 63::US9242969, 63::US9694016, 63 Serine/threonine-protein kinase B-raf Homo sapiens 2.553 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202717&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296698 319495759 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359557 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(c1)N1CCOCC1)N1CCOCC1 InChI=1S/C28H29F3N4O3/c1-19-5-6-23(32-27(36)20-3-2-4-22(15-20)28(29,30)31)18-24(19)21-16-25(34-7-11-37-12-8-34)33-26(17-21)35-9-13-38-14-10-35/h2-6,15-18H,7-14H2,1H3,(H,32,36) JBZRRAJGJPIOCP-UHFFFAOYSA-N 202719 US10245267, Example 65::US10709712, Example 65::US9242969, 65::US9694016, 65 Serine/threonine-protein kinase B-raf Homo sapiens 1.142 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202719&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296701 319495761 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359558 Cc1ccc(NC(=O)c2ccnc(c2)C(C)(C)C#N)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C26H27N5O2/c1-18-4-5-21(30-25(32)20-7-8-28-23(14-20)26(2,3)17-27)16-22(18)19-6-9-29-24(15-19)31-10-12-33-13-11-31/h4-9,14-16H,10-13H2,1-3H3,(H,30,32) ZVINRJBBUUYHRX-UHFFFAOYSA-N 202720 US10245267, Example 66::US10709712, Example 66::US9242969, 66::US9694016, 66 Serine/threonine-protein kinase B-raf Homo sapiens 3.002 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202720&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296702 319495762 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359559 Cc1ccc(NC(=O)c2cccnn2)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C21H21N5O2/c1-15-4-5-17(24-21(27)19-3-2-7-23-25-19)14-18(15)16-6-8-22-20(13-16)26-9-11-28-12-10-26/h2-8,13-14H,9-12H2,1H3,(H,24,27) QFSJWERPFONKIA-UHFFFAOYSA-N 202721 US10245267, Example 67::US10709712, Example 67::US9242969, 67::US9694016, 67 Serine/threonine-protein kinase B-raf Homo sapiens 458.152 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202721&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296703 319495763 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359560 Cc1ccc(NC(=O)c2cccc(c2)S(C)(=O)=O)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C24H25N3O4S/c1-17-6-7-20(26-24(28)19-4-3-5-21(14-19)32(2,29)30)16-22(17)18-8-9-25-23(15-18)27-10-12-31-13-11-27/h3-9,14-16H,10-13H2,1-2H3,(H,26,28) OYRCPJFWDDYQRG-UHFFFAOYSA-N 202722 US10245267, Example 68::US10709712, Example 68::US9242969, 68::US9694016, 68 Serine/threonine-protein kinase B-raf Homo sapiens 0.64 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202722&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296892 319495764 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359561 Cc1ccc(NC(=O)c2ccnc(c2)C(C)(C)C)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C26H30N4O2/c1-18-5-6-21(29-25(31)20-8-9-27-23(15-20)26(2,3)4)17-22(18)19-7-10-28-24(16-19)30-11-13-32-14-12-30/h5-10,15-17H,11-14H2,1-4H3,(H,29,31) INMAGDSAPQEPHY-UHFFFAOYSA-N 202723 US10245267, Example 69::US10709712, Example 69::US9242969, 69::US9694016, 69 Serine/threonine-protein kinase B-raf Homo sapiens 2.054 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202723&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296890 319495765 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359562 Cc1ccc(NC(=O)c2cnccn2)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C21H21N5O2/c1-15-2-3-17(25-21(27)19-14-22-6-7-23-19)13-18(15)16-4-5-24-20(12-16)26-8-10-28-11-9-26/h2-7,12-14H,8-11H2,1H3,(H,25,27) BCZWXKUETCZJNL-UHFFFAOYSA-N 202724 US10245267, Example 70::US10709712, Example 70::US9242969, 70::US9694016, 70 Serine/threonine-protein kinase B-raf Homo sapiens 157 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202724&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409657 319495766 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359563 Cc1ccc(NC(=O)c2cncnc2)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C21H21N5O2/c1-15-2-3-18(25-21(27)17-12-22-14-23-13-17)11-19(15)16-4-5-24-20(10-16)26-6-8-28-9-7-26/h2-5,10-14H,6-9H2,1H3,(H,25,27) BQBDNEAPPRMBAP-UHFFFAOYSA-N 202725 US10245267, Example 71::US10709712, Example 71::US9242969, 71::US9694016, 71 Serine/threonine-protein kinase B-raf Homo sapiens 599.193 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202725&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296891 319495767 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359564 Cc1ccc(NC(=O)c2ccnnc2)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C21H21N5O2/c1-15-2-3-18(25-21(27)17-5-7-23-24-14-17)13-19(15)16-4-6-22-20(12-16)26-8-10-28-11-9-26/h2-7,12-14H,8-11H2,1H3,(H,25,27) WCAXSOQUZPXMLC-UHFFFAOYSA-N 202726 US10245267, Example 72::US10709712, Example 72::US9242969, 72::US9694016, 72 Serine/threonine-protein kinase B-raf Homo sapiens 639.127 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202726&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296893 319495768 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359565 Cc1ccc(NC(=O)c2ccnc(c2)S(C)(=O)=O)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C23H24N4O4S/c1-16-3-4-19(26-23(28)18-6-8-25-22(14-18)32(2,29)30)15-20(16)17-5-7-24-21(13-17)27-9-11-31-12-10-27/h3-8,13-15H,9-12H2,1-2H3,(H,26,28) OJBDIEWQHBNHTP-UHFFFAOYSA-N 202727 US10245267, Example 73::US10709712, Example 73::US9242969, 73::US9694016, 73 Serine/threonine-protein kinase B-raf Homo sapiens 1.499 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202727&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86296894 319495769 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359566 Cc1ccc(NC(=O)c2cccc(c2)C(F)F)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C24H23F2N3O2/c1-16-5-6-20(28-24(30)19-4-2-3-18(13-19)23(25)26)15-21(16)17-7-8-27-22(14-17)29-9-11-31-12-10-29/h2-8,13-15,23H,9-12H2,1H3,(H,28,30) JENDIFUUBSMNTQ-UHFFFAOYSA-N 202729 US10245267, Example 75::US10709712, Example 75::US9242969, 75::US9694016, 75 Serine/threonine-protein kinase B-raf Homo sapiens 0.385 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202729&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297090 319495770 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359567 CN(C)c1cc(cc(n1)N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C InChI=1S/C26H27F3N4O2/c1-17-7-8-21(30-25(34)18-5-4-6-20(13-18)26(27,28)29)16-22(17)19-14-23(32(2)3)31-24(15-19)33-9-11-35-12-10-33/h4-8,13-16H,9-12H2,1-3H3,(H,30,34) PABZMNZFBMSMPR-UHFFFAOYSA-N 202730 US10245267, Example 76::US10709712, Example 76::US9242969, 76::US9694016, 76 Serine/threonine-protein kinase B-raf Homo sapiens 3.222 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202730&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297089 319495771 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359568 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(c1)N1CCOCC1)N1CCOCC1 InChI=1S/C27H28F3N5O3/c1-18-23(16-22(17-31-18)32-26(36)19-3-2-4-21(13-19)27(28,29)30)20-14-24(34-5-9-37-10-6-34)33-25(15-20)35-7-11-38-12-8-35/h2-4,13-17H,5-12H2,1H3,(H,32,36) AQZNVPIHZFYWPU-UHFFFAOYSA-N 202731 US10245267, Example 77::US10709712, Example 77::US9242969, 77::US9694016, 77 Serine/threonine-protein kinase B-raf Homo sapiens 0.632 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202731&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297088 319495772 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359569 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccnc(c1)N1CCO[C@H](CO)C1 InChI=1S/C25H24F3N3O3/c1-16-5-6-20(30-24(33)18-3-2-4-19(11-18)25(26,27)28)13-22(16)17-7-8-29-23(12-17)31-9-10-34-21(14-31)15-32/h2-8,11-13,21,32H,9-10,14-15H2,1H3,(H,30,33)/t21-/m0/s1 RGBVEWZJKRSQCA-NRFANRHFSA-N 202732 US10245267, Example 78::US10709712, Example 78::US9242969, 78::US9694016, 78 Serine/threonine-protein kinase B-raf Homo sapiens 1.49 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202732&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297092 319495773 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359570 C[C@@H]1CO[C@H](CN(C)C)CN1c1cc(ccn1)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)C#N)ccc1C InChI=1S/C30H36N6O2/c1-20-7-8-24(34-29(37)23-10-11-32-27(13-23)30(3,4)19-31)15-26(20)22-9-12-33-28(14-22)36-17-25(16-35(5)6)38-18-21(36)2/h7-15,21,25H,16-18H2,1-6H3,(H,34,37)/t21-,25-/m1/s1 STAZWCVPUNIJEO-PXDATVDWSA-N 202733 US10245267, Example 79::US10709712, Example 79::US9242969, 79::US9694016, 79 Serine/threonine-protein kinase B-raf Homo sapiens 101.957 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202733&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408778 319495774 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359571 C[C@H]1CO[C@@H](CN(C)C)CN1c1cc(ccn1)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)C#N)ccc1C InChI=1S/C30H36N6O2/c1-20-7-8-24(34-29(37)23-10-11-32-27(13-23)30(3,4)19-31)15-26(20)22-9-12-33-28(14-22)36-17-25(16-35(5)6)38-18-21(36)2/h7-15,21,25H,16-18H2,1-6H3,(H,34,37)/t21-,25-/m0/s1 STAZWCVPUNIJEO-OFVILXPXSA-N 202734 US10245267, Example 80::US10709712, Example 80::US9242969, 80::US9694016, 80 Serine/threonine-protein kinase B-raf Homo sapiens 30.653 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202734&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297273 319495775 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359572 CN(C)c1cncc(c1)C(=O)Nc1cnc(C)c(c1)-c1ccnc(c1)N1CCOCC1 InChI=1S/C23H26N6O2/c1-16-21(17-4-5-25-22(11-17)29-6-8-31-9-7-29)12-19(14-26-16)27-23(30)18-10-20(28(2)3)15-24-13-18/h4-5,10-15H,6-9H2,1-3H3,(H,27,30) NTPDQQPEZCMACA-UHFFFAOYSA-N 202735 US10245267, Example 81::US10709712, Example 81::US9242969, 81::US9694016, 81 Serine/threonine-protein kinase B-raf Homo sapiens 14.017 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202735&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297274 319495776 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359573 C[C@@H]1COCCN1c1cc(ccn1)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)C#N)ccc1C InChI=1S/C27H29N5O2/c1-18-5-6-22(31-26(33)21-8-9-29-24(13-21)27(3,4)17-28)15-23(18)20-7-10-30-25(14-20)32-11-12-34-16-19(32)2/h5-10,13-15,19H,11-12,16H2,1-4H3,(H,31,33)/t19-/m1/s1 JWBUKPMOLLPTEL-LJQANCHMSA-N 202736 US10245267, Example 82::US10709712, Example 82::US9242969, 82::US9694016, 82 Serine/threonine-protein kinase B-raf Homo sapiens 14.469 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202736&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297091 319495777 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359574 Cc1ccc(NC(=O)c2ccnc(c2)C(C)(C)C#N)cc1-c1ccnc(c1)N1CCO[C@H](CO)C1 InChI=1S/C27H29N5O3/c1-18-4-5-21(31-26(34)20-7-8-29-24(12-20)27(2,3)17-28)14-23(18)19-6-9-30-25(13-19)32-10-11-35-22(15-32)16-33/h4-9,12-14,22,33H,10-11,15-16H2,1-3H3,(H,31,34)/t22-/m0/s1 PGYUGYRBRUPMST-QFIPXVFZSA-N 202737 US10245267, Example 83::US10709712, Example 83::US9242969, 83::US9694016, 83 Serine/threonine-protein kinase B-raf Homo sapiens 2.533 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202737&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442601 319495778 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359575 CNC[C@@H]1CN(CCO1)c1cc(ccn1)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)C#N)ccc1C InChI=1S/C28H32N6O2/c1-19-5-6-22(33-27(35)21-8-9-31-25(13-21)28(2,3)18-29)15-24(19)20-7-10-32-26(14-20)34-11-12-36-23(17-34)16-30-4/h5-10,13-15,23,30H,11-12,16-17H2,1-4H3,(H,33,35)/t23-/m1/s1 WWYRVCWQGYBXSH-HSZRJFAPSA-N 202738 US10245267, Example 84::US10709712, Example 84::US9242969, 84::US9694016, 84 Serine/threonine-protein kinase B-raf Homo sapiens 2.927 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202738&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297275 319495779 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359576 CC(=O)NC[C@@H]1CN(CCO1)c1cc(ccn1)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)C#N)ccc1C InChI=1S/C29H32N6O3/c1-19-5-6-23(34-28(37)22-8-9-31-26(13-22)29(3,4)18-30)15-25(19)21-7-10-32-27(14-21)35-11-12-38-24(17-35)16-33-20(2)36/h5-10,13-15,24H,11-12,16-17H2,1-4H3,(H,33,36)(H,34,37)/t24-/m1/s1 HFNOOFKUMLMGGI-XMMPIXPASA-N 202739 US10245267, Example 85::US10709712, Example 85::US9242969, 85::US9694016, 85 Serine/threonine-protein kinase B-raf Homo sapiens 10.918 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202739&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297475 319495780 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359577 COC(=O)NC[C@@H]1CN(CCO1)c1cc(ccn1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)cnc1C InChI=1S/C26H26F3N5O4/c1-16-22(12-20(13-31-16)33-24(35)18-4-3-5-19(10-18)26(27,28)29)17-6-7-30-23(11-17)34-8-9-38-21(15-34)14-32-25(36)37-2/h3-7,10-13,21H,8-9,14-15H2,1-2H3,(H,32,36)(H,33,35)/t21-/m1/s1 IPWUKCMMNPEWPT-OAQYLSRUSA-N 202740 US10245267, Example 86::US10709712, Example 86::US9242969, 86::US9694016, 86 Serine/threonine-protein kinase B-raf Homo sapiens 8.43 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202740&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442602 319495781 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359578 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccnc(c1)N1CCO[C@H](CNC(=O)CO)C1 InChI=1S/C26H26F3N5O4/c1-16-22(11-20(12-31-16)33-25(37)18-3-2-4-19(9-18)26(27,28)29)17-5-6-30-23(10-17)34-7-8-38-21(14-34)13-32-24(36)15-35/h2-6,9-12,21,35H,7-8,13-15H2,1H3,(H,32,36)(H,33,37)/t21-/m1/s1 OZOULXXAHRUJJL-OAQYLSRUSA-N 202741 US10245267, Example 87::US10709712, Example 87::US9242969, 87::US9694016, 87 Serine/threonine-protein kinase B-raf Homo sapiens 12.091 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202741&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408063 319495782 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359579 COc1ncc(NC(=O)c2ccnc(c2)C(C)(C)C#N)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C25H26N6O3/c1-25(2,16-26)21-12-18(5-6-27-21)23(32)30-19-14-20(24(33-3)29-15-19)17-4-7-28-22(13-17)31-8-10-34-11-9-31/h4-7,12-15H,8-11H2,1-3H3,(H,30,32) DGVMTMIZIBKSLP-UHFFFAOYSA-N 202742 US10245267, Example 88::US10709712, Example 88::US9242969, 88::US9694016, 1170 Serine/threonine-protein kinase B-raf Homo sapiens 37.439 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202742&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297277 319495783 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359580 CC(F)(F)c1cc(ccn1)C(=O)Nc1c[nH]c(=O)c(c1)-c1ccnc(c1)N1CCOCC1 InChI=1S/C22H21F2N5O3/c1-22(23,24)18-10-15(3-4-25-18)20(30)28-16-12-17(21(31)27-13-16)14-2-5-26-19(11-14)29-6-8-32-9-7-29/h2-5,10-13H,6-9H2,1H3,(H,27,31)(H,28,30) MHXDDBSOWRGCEL-UHFFFAOYSA-N 202743 US10245267, Example 89::US10709712, Example 89::US9242969, 89::US9694016, 1171 Serine/threonine-protein kinase B-raf Homo sapiens >25000.34 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202743&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127053722 319495784 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359581 FC(F)(F)c1cc(ccn1)C(=O)Nc1c[nH]c(=O)c(c1)-c1ccnc(c1)N1CCOCC1 InChI=1S/C21H18F3N5O3/c22-21(23,24)17-9-14(2-3-25-17)19(30)28-15-11-16(20(31)27-12-15)13-1-4-26-18(10-13)29-5-7-32-8-6-29/h1-4,9-12H,5-8H2,(H,27,31)(H,28,30) PDCWNMAIMBYGOD-UHFFFAOYSA-N 202744 US10245267, Example 90::US10709712, Example 90::US9242969, 90::US9694016, 1172 Serine/threonine-protein kinase B-raf Homo sapiens >25000.34 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202744&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127053723 319495785 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359582 CC(C)(C#N)c1cc(ccn1)C(=O)Nc1c[nH]c(=O)c(c1)-c1ccnc(c1)N1CCOCC1 InChI=1S/C24H24N6O3/c1-24(2,15-25)20-11-17(4-5-26-20)22(31)29-18-13-19(23(32)28-14-18)16-3-6-27-21(12-16)30-7-9-33-10-8-30/h3-6,11-14H,7-10H2,1-2H3,(H,28,32)(H,29,31) PTQWLEFABJSRKO-UHFFFAOYSA-N 202745 US10245267, Example 91::US10709712, Example 91::US9242969, 91::US9694016, 1173 Serine/threonine-protein kinase B-raf Homo sapiens 18594.788 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202745&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127053724 319495786 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359583 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N)nc(c1)N1CCOCC1 InChI=1S/C24H23F3N4O2/c1-15-5-6-19(29-23(32)16-3-2-4-18(11-16)24(25,26)27)14-20(15)17-12-21(28)30-22(13-17)31-7-9-33-10-8-31/h2-6,11-14H,7-10H2,1H3,(H2,28,30)(H,29,32) BYOVYFARSYCHOS-UHFFFAOYSA-N 202747 US10245267, Example 93::US10709712, Example 93::US9242969, 93::US9694016, 93 Serine/threonine-protein kinase B-raf Homo sapiens 0.802 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202747&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297477 319495787 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359584 CCn1cc(cc(c1=O)C(F)(F)F)C(=O)Nc1ccc(C)c(c1)-c1ccnc(c1)N1CCOCC1 InChI=1S/C25H25F3N4O3/c1-3-31-15-18(12-21(24(31)34)25(26,27)28)23(33)30-19-5-4-16(2)20(14-19)17-6-7-29-22(13-17)32-8-10-35-11-9-32/h4-7,12-15H,3,8-11H2,1-2H3,(H,30,33) CCCXUVYYHIWBRQ-UHFFFAOYSA-N 202748 US10245267, Example 94::US10709712, Example 94::US9242969, 94::US9694016, 94 Serine/threonine-protein kinase B-raf Homo sapiens 5.788 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202748&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409532 319495788 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359585 Cc1ncc(NC(=O)c2ccnc(c2)C(C)(C)C#N)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C25H26N6O2/c1-17-21(18-4-7-28-23(13-18)31-8-10-33-11-9-31)14-20(15-29-17)30-24(32)19-5-6-27-22(12-19)25(2,3)16-26/h4-7,12-15H,8-11H2,1-3H3,(H,30,32) CFSCYQHLBXZELG-UHFFFAOYSA-N 202749 US10245267, Example 95::US10709712, Example 95::US9242969, 95::US9694016, 95 Serine/threonine-protein kinase B-raf Homo sapiens 13.459 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202749&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297687 319495789 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359586 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C23H21F3N4O2/c1-15-20(16-5-6-27-21(12-16)30-7-9-32-10-8-30)13-19(14-28-15)29-22(31)17-3-2-4-18(11-17)23(24,25)26/h2-6,11-14H,7-10H2,1H3,(H,29,31) ITCUYRPGRFYIBZ-UHFFFAOYSA-N 202750 US10245267, Example 96::US10709712, Example 96::US9242969, 96::US9694016, 96 Serine/threonine-protein kinase B-raf Homo sapiens 1.241 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202750&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297691 319495790 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359587 COc1ccc(cc1C(F)(F)F)C(=O)Nc1cnc(C)c(c1)-c1ccnc(c1)N1CCOCC1 InChI=1S/C24H23F3N4O3/c1-15-19(16-5-6-28-22(12-16)31-7-9-34-10-8-31)13-18(14-29-15)30-23(32)17-3-4-21(33-2)20(11-17)24(25,26)27/h3-6,11-14H,7-10H2,1-2H3,(H,30,32) ICSXPPDQFDQGTE-UHFFFAOYSA-N 202751 US10245267, Example 97::US10709712, Example 97::US9242969, 97::US9694016, 97 Serine/threonine-protein kinase B-raf Homo sapiens 9.087 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202751&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297276 319495791 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359588 COc1cc(ccc1F)C(=O)Nc1cnc(C)c(c1)-c1ccnc(c1)N1CCOCC1 InChI=1S/C23H23FN4O3/c1-15-19(16-5-6-25-22(12-16)28-7-9-31-10-8-28)13-18(14-26-15)27-23(29)17-3-4-20(24)21(11-17)30-2/h3-6,11-14H,7-10H2,1-2H3,(H,27,29) VNTMVGFGGXWVQD-UHFFFAOYSA-N 202752 US10245267, Example 98::US10709712, Example 98::US9242969, 98::US9694016, 98 Serine/threonine-protein kinase B-raf Homo sapiens 25.693 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202752&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297479 319495792 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359589 Cc1ncc(NC(=O)c2cccc(c2)C(F)F)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C23H22F2N4O2/c1-15-20(16-5-6-26-21(12-16)29-7-9-31-10-8-29)13-19(14-27-15)28-23(30)18-4-2-3-17(11-18)22(24)25/h2-6,11-14,22H,7-10H2,1H3,(H,28,30) AUZAPTUBDQMDLQ-UHFFFAOYSA-N 202753 US10245267, Example 99::US10709712, Example 99::US9242969, 99::US9694016, 99 Serine/threonine-protein kinase B-raf Homo sapiens 1.17 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202753&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297480 319495793 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359590 Cc1ncc(NC(=O)c2ccnc(c2)C(C)(F)F)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C23H23F2N5O2/c1-15-19(16-3-6-27-21(12-16)30-7-9-32-10-8-30)13-18(14-28-15)29-22(31)17-4-5-26-20(11-17)23(2,24)25/h3-6,11-14H,7-10H2,1-2H3,(H,29,31) ZAPJTTHBHRSAGS-UHFFFAOYSA-N 202754 US10245267, Example 100::US10709712, Example 100::US9242969, 100::US9694016, 100 Serine/threonine-protein kinase B-raf Homo sapiens 4.089 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202754&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297886 319495794 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359591 Cc1ncc(NC(=O)c2cccc(c2)C(C)(F)F)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C24H24F2N4O2/c1-16-21(17-6-7-27-22(13-17)30-8-10-32-11-9-30)14-20(15-28-16)29-23(31)18-4-3-5-19(12-18)24(2,25)26/h3-7,12-15H,8-11H2,1-2H3,(H,29,31) JMDULIJMVPCUQN-UHFFFAOYSA-N 202755 US10245267, Example 101::US10709712, Example 101::US9242969, 101::US9694016, 101 Serine/threonine-protein kinase B-raf Homo sapiens 2.183 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202755&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297692 319495795 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359592 Cc1ncc(NC(=O)c2ccnc(c2)S(C)(=O)=O)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C22H23N5O4S/c1-15-19(16-3-5-23-20(11-16)27-7-9-31-10-8-27)13-18(14-25-15)26-22(28)17-4-6-24-21(12-17)32(2,29)30/h3-6,11-14H,7-10H2,1-2H3,(H,26,28) UDAKXGQSHNCYDD-UHFFFAOYSA-N 202756 US10245267, Example 102::US10709712, Example 102::US9242969, 102::US9694016, 102 Serine/threonine-protein kinase B-raf Homo sapiens 28.046 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202756&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297689 319495796 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359593 Cc1ncc(NC(=O)c2cccc(c2)S(C)(=O)=O)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C23H24N4O4S/c1-16-21(17-6-7-24-22(13-17)27-8-10-31-11-9-27)14-19(15-25-16)26-23(28)18-4-3-5-20(12-18)32(2,29)30/h3-7,12-15H,8-11H2,1-2H3,(H,26,28) BOFJGENBYWHBQW-UHFFFAOYSA-N 202757 US10245267, Example 103::US10709712, Example 103::US9242969, 103::US9694016, 103 Serine/threonine-protein kinase B-raf Homo sapiens 18.432 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202757&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297888 319495797 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359594 Cc1ncc(NC(=O)c2ccnc(c2)C(C)(C)C)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C25H29N5O2/c1-17-21(18-5-8-27-23(14-18)30-9-11-32-12-10-30)15-20(16-28-17)29-24(31)19-6-7-26-22(13-19)25(2,3)4/h5-8,13-16H,9-12H2,1-4H3,(H,29,31) CCLMBXZFMXSFCV-UHFFFAOYSA-N 202758 US10245267, Example 104::US10709712, Example 104::US9242969, 104::US9694016, 104 Serine/threonine-protein kinase B-raf Homo sapiens 38.535 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202758&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297887 319495798 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359595 Cc1ccc(NC(=O)c2ccnc(c2)C(C)(C)C#N)cc1-c1cc(nc(c1)N1CCOCC1)C1CCOCC1 InChI=1S/C31H35N5O3/c1-21-4-5-25(34-30(37)23-6-9-33-28(17-23)31(2,3)20-32)19-26(21)24-16-27(22-7-12-38-13-8-22)35-29(18-24)36-10-14-39-15-11-36/h4-6,9,16-19,22H,7-8,10-15H2,1-3H3,(H,34,37) YWXHCAQISAEKBP-UHFFFAOYSA-N 202759 US10245267, Example 106::US10709712, Example 106::US9242969, 106::US9694016, 106 Serine/threonine-protein kinase B-raf Homo sapiens 1.708 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202759&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297889 319495799 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359596 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(c1)N1CCOCC1)C1CCOCC1 InChI=1S/C29H30F3N3O3/c1-19-5-6-24(33-28(36)21-3-2-4-23(15-21)29(30,31)32)18-25(19)22-16-26(20-7-11-37-12-8-20)34-27(17-22)35-9-13-38-14-10-35/h2-6,15-18,20H,7-14H2,1H3,(H,33,36) DJEJCPKGTQTKTH-UHFFFAOYSA-N 202760 US10245267, Example 107::US10709712, Example 107::US9242969, 107::US9694016, 107 Serine/threonine-protein kinase B-raf Homo sapiens 1.688 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202760&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297890 319495800 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359597 OCc1ccc(cc1-c1ccnc(c1)N1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C24H22F3N3O3/c25-24(26,27)19-2-1-3-20(14-19)29-23(32)17-4-5-18(15-31)21(12-17)16-6-7-28-22(13-16)30-8-10-33-11-9-30/h1-7,12-14,31H,8-11,15H2,(H,29,32) KHLFEDBCFCMGBK-UHFFFAOYSA-N 202761 US10245267, Example 108::US10709712, Example 108::US9242969, 108::US9694016, 108 Serine/threonine-protein kinase B-raf Homo sapiens 6.113 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202761&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86298091 319495801 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359598 FC(F)c1ccc(cc1-c1ccnc(c1)N1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C24H20F5N3O2/c25-22(26)19-5-4-16(23(33)31-18-3-1-2-17(14-18)24(27,28)29)12-20(19)15-6-7-30-21(13-15)32-8-10-34-11-9-32/h1-7,12-14,22H,8-11H2,(H,31,33) IYANNOOOCLOAND-UHFFFAOYSA-N 202762 US10245267, Example 109::US10709712, Example 109::US9242969, 109::US9694016, 109 Serine/threonine-protein kinase B-raf Homo sapiens 5.035 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202762&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86298092 319495802 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359599 FCc1ccc(cc1-c1ccnc(c1)N1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C24H21F4N3O2/c25-15-18-5-4-17(23(32)30-20-3-1-2-19(14-20)24(26,27)28)12-21(18)16-6-7-29-22(13-16)31-8-10-33-11-9-31/h1-7,12-14H,8-11,15H2,(H,30,32) HADQWOUFZYOCND-UHFFFAOYSA-N 202763 US10245267, Example 110::US10709712, Example 110::US9242969, 110::US9694016, 110 Serine/threonine-protein kinase B-raf Homo sapiens 2.185 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202763&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86297690 319495803 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359600 Cc1ccc(cc1-c1cc(nc(c1)N1CCOCC1)N1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C28H29F3N4O3/c1-19-5-6-20(27(36)32-23-4-2-3-22(18-23)28(29,30)31)15-24(19)21-16-25(34-7-11-37-12-8-34)33-26(17-21)35-9-13-38-14-10-35/h2-6,15-18H,7-14H2,1H3,(H,32,36) XIEGUNPXGANEIU-UHFFFAOYSA-N 202765 US10245267, Example 112::US10709712, Example 112::US9242969, 112::US9694016, 112 Serine/threonine-protein kinase B-raf Homo sapiens 2.384 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202765&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86298095 319495805 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359601 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(c1)-c1cnn(C)c1)N1CCOCC1 InChI=1S/C28H26F3N5O2/c1-18-6-7-23(33-27(37)19-4-3-5-22(12-19)28(29,30)31)15-24(18)20-13-25(21-16-32-35(2)17-21)34-26(14-20)36-8-10-38-11-9-36/h3-7,12-17H,8-11H2,1-2H3,(H,33,37) BRHVOQCQIFRMBJ-UHFFFAOYSA-N 202766 US10245267, Example 113::US10709712, Example 113::US9242969, 113::US9694016, 113 Serine/threonine-protein kinase B-raf Homo sapiens 1.137 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202766&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408411 319495806 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359602 Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1-c1cc(nc(c1)N1CCOCC1)C1CCOCC1 InChI=1S/C32H36N4O3/c1-22-7-8-27(34-31(37)24-5-4-6-26(17-24)32(2,3)21-33)20-28(22)25-18-29(23-9-13-38-14-10-23)35-30(19-25)36-11-15-39-16-12-36/h4-8,17-20,23H,9-16H2,1-3H3,(H,34,37) CJIKCAUEUGYYMV-UHFFFAOYSA-N 202767 US10245267, Example 114::US10709712, Example 114::US9242969, 114::US9694016, 114 Serine/threonine-protein kinase B-raf Homo sapiens 1.626 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202767&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408004 319495807 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359603 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(NCCO)nc(c1)N1CCOCC1 InChI=1S/C26H27F3N4O3/c1-17-5-6-21(31-25(35)18-3-2-4-20(13-18)26(27,28)29)16-22(17)19-14-23(30-7-10-34)32-24(15-19)33-8-11-36-12-9-33/h2-6,13-16,34H,7-12H2,1H3,(H,30,32)(H,31,35) JALUVCXDDMPCDN-UHFFFAOYSA-N 202768 US10245267, Example 115::US10709712, Example 115::US9242969, 115::US9694016, 115 Serine/threonine-protein kinase B-raf Homo sapiens 12.797 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202768&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86298302 319495808 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359604 CCn1cc(cc(c1=O)C(F)(F)F)C(=O)Nc1ccc(C)c(c1)-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C26H27F3N4O4/c1-4-32-15-18(11-21(24(32)35)26(27,28)29)23(34)30-19-6-5-16(2)20(13-19)17-12-22(25(36)31(3)14-17)33-7-9-37-10-8-33/h5-6,11-15H,4,7-10H2,1-3H3,(H,30,34) MKZSFPJXPHOTDV-UHFFFAOYSA-N 202769 US10245267, Example 116::US10709712, Example 116::US9242969, 116::US9694016, 116 Serine/threonine-protein kinase B-raf Homo sapiens 10.923 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202769&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90407968 319495809 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359605 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C25H24F3N3O3/c1-16-6-7-20(29-23(32)17-4-3-5-19(12-17)25(26,27)28)14-21(16)18-13-22(24(33)30(2)15-18)31-8-10-34-11-9-31/h3-7,12-15H,8-11H2,1-2H3,(H,29,32) IINLTCRAWJXNKT-UHFFFAOYSA-N 202770 US10245267, Example 117::US10709712, Example 117::US9242969, 117::US9694016, 117 Serine/threonine-protein kinase B-raf Homo sapiens 2.035 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202770&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408889 319495810 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359606 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cncc(n1)N1CCOCC1 InChI=1S/C23H21F3N4O2/c1-15-5-6-18(28-22(31)16-3-2-4-17(11-16)23(24,25)26)12-19(15)20-13-27-14-21(29-20)30-7-9-32-10-8-30/h2-6,11-14H,7-10H2,1H3,(H,28,31) IVNFWAVJWXWTLH-UHFFFAOYSA-N 202771 US10245267, Example 118::US10709712, Example 118::US9242969, 118::US9694016, 118 Serine/threonine-protein kinase B-raf Homo sapiens 1.003 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202771&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409447 319495811 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359607 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1c[nH]c(=O)c(n1)N1CCOCC1 InChI=1S/C23H21F3N4O3/c1-14-5-6-17(28-21(31)15-3-2-4-16(11-15)23(24,25)26)12-18(14)19-13-27-22(32)20(29-19)30-7-9-33-10-8-30/h2-6,11-13H,7-10H2,1H3,(H,27,32)(H,28,31) WQAAGADGLQVCDN-UHFFFAOYSA-N 202773 US10245267, Example 120::US10709712, Example 120::US9242969, 120::US9694016, 120 Serine/threonine-protein kinase B-raf Homo sapiens 1.214 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202773&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122362957 319495813 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359608 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1c[nH]c(=O)c(n1)N1CCOCC1 InChI=1S/C22H20F3N5O3/c1-13-17(18-12-27-21(32)19(29-18)30-5-7-33-8-6-30)10-16(11-26-13)28-20(31)14-3-2-4-15(9-14)22(23,24)25/h2-4,9-12H,5-8H2,1H3,(H,27,32)(H,28,31) YJAQBROIDYROSH-UHFFFAOYSA-N 202774 US10245267, Example 121::US10709712, Example 121::US9242969, 121::US9694016, 121 Serine/threonine-protein kinase B-raf Homo sapiens 4.451 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202774&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122362958 319495814 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359609 COc1ncc(cc1-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C)N1CCOCC1 InChI=1S/C25H24F3N3O3/c1-16-6-7-19(30-23(32)17-4-3-5-18(12-17)25(26,27)28)13-21(16)22-14-20(15-29-24(22)33-2)31-8-10-34-11-9-31/h3-7,12-15H,8-11H2,1-2H3,(H,30,32) UZEQVEDIWADYDO-UHFFFAOYSA-N 202775 US10245267, Example 122::US10709712, Example 122::US9242969, 122::US9694016, 122 Serine/threonine-protein kinase B-raf Homo sapiens 3.877 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202775&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295254 319495815 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359610 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(cn(C)c1=O)N1CCOCC1 InChI=1S/C25H24F3N3O3/c1-16-6-7-19(29-23(32)17-4-3-5-18(12-17)25(26,27)28)13-21(16)22-14-20(15-30(2)24(22)33)31-8-10-34-11-9-31/h3-7,12-15H,8-11H2,1-2H3,(H,29,32) MILCLACBBNYLMZ-UHFFFAOYSA-N 202776 US10245267, Example 123::US10709712, Example 123::US9242969, 123::US9694016, 123 Serine/threonine-protein kinase B-raf Homo sapiens 23.164 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202776&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86295255 319495816 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359611 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(cn(C)c1=O)N1CCOCC1 InChI=1S/C24H23F3N4O3/c1-15-20(21-12-19(14-30(2)23(21)33)31-6-8-34-9-7-31)11-18(13-28-15)29-22(32)16-4-3-5-17(10-16)24(25,26)27/h3-5,10-14H,6-9H2,1-2H3,(H,29,32) PHWHELVHLQDYNV-UHFFFAOYSA-N 202777 US10245267, Example 124::US10709712, Example 124::US9242969, 124::US9694016, 124 Serine/threonine-protein kinase B-raf Homo sapiens 82.672 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202777&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 86298306 319495817 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359612 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(c[nH]c1=O)N1CCOCC1 InChI=1S/C24H22F3N3O3/c1-15-5-6-18(29-22(31)16-3-2-4-17(11-16)24(25,26)27)12-20(15)21-13-19(14-28-23(21)32)30-7-9-33-10-8-30/h2-6,11-14H,7-10H2,1H3,(H,28,32)(H,29,31) BVFVIFLOVGLFJR-UHFFFAOYSA-N 202778 US10245267, Example 125::US10709712, Example 125::US9242969, 125::US9694016, 125 Serine/threonine-protein kinase B-raf Homo sapiens 22.327 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202778&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122362959 319495818 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359613 COc1ncc(cc1N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C InChI=1S/C25H24F3N3O3/c1-16-6-7-20(30-23(32)17-4-3-5-19(12-17)25(26,27)28)14-21(16)18-13-22(24(33-2)29-15-18)31-8-10-34-11-9-31/h3-7,12-15H,8-11H2,1-2H3,(H,30,32) BHICALKRKYZBTH-UHFFFAOYSA-N 202779 US10245267, Example 126::US10709712, Example 126::US9242969, 126::US9694016, 126 Serine/threonine-protein kinase B-raf Homo sapiens 1.07 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202779&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408193 319495819 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359614 COc1ncc(cc1N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)cnc1C InChI=1S/C24H23F3N4O3/c1-15-20(17-11-21(23(33-2)29-13-17)31-6-8-34-9-7-31)12-19(14-28-15)30-22(32)16-4-3-5-18(10-16)24(25,26)27/h3-5,10-14H,6-9H2,1-2H3,(H,30,32) BSUIIPUXGLKINZ-UHFFFAOYSA-N 202780 US10245267, Example 127::US10709712, Example 127::US9242969, 127::US9694016, 127 Serine/threonine-protein kinase B-raf Homo sapiens 1.667 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202780&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408582 319495820 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359615 COc1ncc(cc1N1CCOCC1)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)C#N)ccc1C InChI=1S/C27H29N5O3/c1-18-5-6-21(31-25(33)19-7-8-29-24(14-19)27(2,3)17-28)15-22(18)20-13-23(26(34-4)30-16-20)32-9-11-35-12-10-32/h5-8,13-16H,9-12H2,1-4H3,(H,31,33) RMODVQQXAZVOQC-UHFFFAOYSA-N 202781 US10245267, Example 128::US10709712, Example 128::US9242969, 128::US9694016, 128 Serine/threonine-protein kinase B-raf Homo sapiens 3.782 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202781&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408886 319495821 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359616 COc1ncc(cc1N1CCOCC1)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)C#N)cnc1C InChI=1S/C26H28N6O3/c1-17-21(19-11-22(25(34-4)30-14-19)32-7-9-35-10-8-32)13-20(15-29-17)31-24(33)18-5-6-28-23(12-18)26(2,3)16-27/h5-6,11-15H,7-10H2,1-4H3,(H,31,33) STHQWWOCJPWQET-UHFFFAOYSA-N 202782 US10245267, Example 129::US10709712, Example 129::US9242969, 129::US9694016, 129 Serine/threonine-protein kinase B-raf Homo sapiens 13.441 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202782&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409311 319495822 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359617 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(c1)C1CCOCC1 InChI=1S/C28H29F3N4O4/c1-18-24(15-22(16-32-18)33-26(36)19-3-2-4-21(13-19)28(29,30)31)20-14-25(34-7-11-39-12-8-34)27(37)35(17-20)23-5-9-38-10-6-23/h2-4,13-17,23H,5-12H2,1H3,(H,33,36) HQVKJIWNVNEHBE-UHFFFAOYSA-N 202783 US10245267, Example 130::US10709712, Example 130::US9242969, 130::US9694016, 130 Serine/threonine-protein kinase B-raf Homo sapiens 5.77 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202783&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408058 319495823 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359618 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cnc(OC2CCOCC2)c(c1)N1CCOCC1 InChI=1S/C28H29F3N4O4/c1-18-24(15-22(17-32-18)34-26(36)19-3-2-4-21(13-19)28(29,30)31)20-14-25(35-7-11-38-12-8-35)27(33-16-20)39-23-5-9-37-10-6-23/h2-4,13-17,23H,5-12H2,1H3,(H,34,36) FYNMINFUAIDIFL-UHFFFAOYSA-N 202784 US10245267, Example 131::US10709712, Example 131::US9242969, 131::US9694016, 131 Serine/threonine-protein kinase B-raf Homo sapiens 0.483 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202784&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 92J 5VAM 90408826 319495824 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359619 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cnc(OC2CCOCC2)c(c1)N1CCOCC1 InChI=1S/C29H30F3N3O4/c1-19-5-6-23(34-27(36)20-3-2-4-22(15-20)29(30,31)32)17-25(19)21-16-26(35-9-13-38-14-10-35)28(33-18-21)39-24-7-11-37-12-8-24/h2-6,15-18,24H,7-14H2,1H3,(H,34,36) NWUJNMRBRDSYBD-UHFFFAOYSA-N 202785 US10245267, Example 132::US10709712, Example 132::US9242969, 132::US9694016, 132 Serine/threonine-protein kinase B-raf Homo sapiens 2.708 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202785&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408156 319495825 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359620 CC(C)n1cc(cc(N2CCOCC2)c1=O)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)cnc1C InChI=1S/C26H27F3N4O3/c1-16(2)33-15-19(12-23(25(33)35)32-7-9-36-10-8-32)22-13-21(14-30-17(22)3)31-24(34)18-5-4-6-20(11-18)26(27,28)29/h4-6,11-16H,7-10H2,1-3H3,(H,31,34) LFXMCPPFKLHZKO-UHFFFAOYSA-N 202786 US10245267, Example 133::US10709712, Example 133::US9242969, 133::US9694016, 133 Serine/threonine-protein kinase B-raf Homo sapiens 28.875 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202786&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408333 319495826 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359621 CC(C)Oc1ncc(cc1N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)cnc1C InChI=1S/C26H27F3N4O3/c1-16(2)36-25-23(33-7-9-35-10-8-33)12-19(14-31-25)22-13-21(15-30-17(22)3)32-24(34)18-5-4-6-20(11-18)26(27,28)29/h4-6,11-16H,7-10H2,1-3H3,(H,32,34) HSMGIQDGRRTVOS-UHFFFAOYSA-N 202787 US10245267, Example 134::US10709712, Example 134::US9242969, 134::US9694016, 134 Serine/threonine-protein kinase B-raf Homo sapiens 3.64 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202787&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90407961 319495827 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359622 CC(C)n1cc(cc(N2CCOCC2)c1=O)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C InChI=1S/C27H28F3N3O3/c1-17(2)33-16-20(14-24(26(33)35)32-9-11-36-12-10-32)23-15-22(8-7-18(23)3)31-25(34)19-5-4-6-21(13-19)27(28,29)30/h4-8,13-17H,9-12H2,1-3H3,(H,31,34) QGEZANVCDSIDGU-UHFFFAOYSA-N 202788 US10245267, Example 135::US10709712, Example 135::US9242969, 135::US9694016, 135 Serine/threonine-protein kinase B-raf Homo sapiens 3.957 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202788&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408770 319495828 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359623 CC(C)Oc1ncc(cc1N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C InChI=1S/C27H28F3N3O3/c1-17(2)36-26-24(33-9-11-35-12-10-33)14-20(16-31-26)23-15-22(8-7-18(23)3)32-25(34)19-5-4-6-21(13-19)27(28,29)30/h4-8,13-17H,9-12H2,1-3H3,(H,32,34) RINDPRPVBOGYGN-UHFFFAOYSA-N 202789 US10245267, Example 136::US10709712, Example 136::US9242969, 136::US9694016, 136 Serine/threonine-protein kinase B-raf Homo sapiens 4.173 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202789&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409412 319495829 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359624 Cc1ccc(cc1-c1cc(N2CCOCC2)c(=O)n(C)c1)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C25H24F3N3O3/c1-16-6-7-17(23(32)29-20-5-3-4-19(14-20)25(26,27)28)12-21(16)18-13-22(24(33)30(2)15-18)31-8-10-34-11-9-31/h3-7,12-15H,8-11H2,1-2H3,(H,29,32) WMUYNQKBTHBDDB-UHFFFAOYSA-N 202790 US10245267, Example 137::US10709712, Example 137::US9242969, 137::US9694016, 137 Serine/threonine-protein kinase B-raf Homo sapiens 3.792 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202790&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408293 319495830 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359625 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C24H23F3N4O3/c1-15-20(17-11-21(23(33)30(2)14-17)31-6-8-34-9-7-31)12-19(13-28-15)29-22(32)16-4-3-5-18(10-16)24(25,26)27/h3-5,10-14H,6-9H2,1-2H3,(H,29,32) NLRKKGQQNSZMJI-UHFFFAOYSA-N 202791 US10245267, Example 138::US10709712, Example 138::US9242969, 138::US9694016, 138 Serine/threonine-protein kinase B-raf Homo sapiens 3.112 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202791&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442604 319495831 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359626 Cc1ccc(NC(=O)c2ccnc(c2)C(C)(C)C)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C27H32N4O3/c1-18-6-7-21(29-25(32)19-8-9-28-24(15-19)27(2,3)4)16-22(18)20-14-23(26(33)30(5)17-20)31-10-12-34-13-11-31/h6-9,14-17H,10-13H2,1-5H3,(H,29,32) QKRZIJKGUSHRML-UHFFFAOYSA-N 202792 US10245267, Example 139::US10709712, Example 139::US9242969, 139::US9694016, 139 Serine/threonine-protein kinase B-raf Homo sapiens 2.454 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202792&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408834 319495832 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359627 Cc1ccc(NC(=O)c2ccnc(c2)C(C)(C)C#N)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C27H29N5O3/c1-18-5-6-21(30-25(33)19-7-8-29-24(14-19)27(2,3)17-28)15-22(18)20-13-23(26(34)31(4)16-20)32-9-11-35-12-10-32/h5-8,13-16H,9-12H2,1-4H3,(H,30,33) OEJFUUXOBQVTCG-UHFFFAOYSA-N 202793 US10245267, Example 140::US10709712, Example 140::US9242969, 140::US9694016, 140 Serine/threonine-protein kinase B-raf Homo sapiens 2.5 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202793&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90410245 319495833 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359628 Cc1ncc(NC(=O)c2ccnc(c2)C(C)(C)C#N)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C26H28N6O3/c1-17-21(19-11-22(25(34)31(4)15-19)32-7-9-35-10-8-32)13-20(14-29-17)30-24(33)18-5-6-28-23(12-18)26(2,3)16-27/h5-6,11-15H,7-10H2,1-4H3,(H,30,33) SFAHMYNGMYEECP-UHFFFAOYSA-N 202794 US10245267, Example 141::US10709712, Example 141::US9242969, 141::US9694016, 141 Serine/threonine-protein kinase B-raf Homo sapiens 34.633 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202794&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408007 319495834 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359629 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(CCO)c1 InChI=1S/C26H26F3N3O4/c1-17-5-6-21(30-24(34)18-3-2-4-20(13-18)26(27,28)29)15-22(17)19-14-23(31-8-11-36-12-9-31)25(35)32(16-19)7-10-33/h2-6,13-16,33H,7-12H2,1H3,(H,30,34) BQIZJHQAWBIMRZ-UHFFFAOYSA-N 202795 US10245267, Example 142::US10709712, Example 142::US9242969, 142::US9694016, 142 Serine/threonine-protein kinase B-raf Homo sapiens 2.23 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202795&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408194 319495835 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359630 Cc1ccc(NC(=O)c2ccnc(c2)C(C)(C)C#N)cc1-c1cc(N2CCOCC2)c(=O)n(CCO)c1 InChI=1S/C28H31N5O4/c1-19-4-5-22(31-26(35)20-6-7-30-25(15-20)28(2,3)18-29)16-23(19)21-14-24(32-9-12-37-13-10-32)27(36)33(17-21)8-11-34/h4-7,14-17,34H,8-13H2,1-3H3,(H,31,35) GGDWRDONSOKHNJ-UHFFFAOYSA-N 202796 US10245267, Example 143::US10709712, Example 143::US9242969, 143::US9694016, 143 Serine/threonine-protein kinase B-raf Homo sapiens 9.98 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202796&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408967 319495836 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359631 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(CCO)c1 InChI=1S/C25H25F3N4O4/c1-16-21(18-12-22(31-6-9-36-10-7-31)24(35)32(15-18)5-8-33)13-20(14-29-16)30-23(34)17-3-2-4-19(11-17)25(26,27)28/h2-4,11-15,33H,5-10H2,1H3,(H,30,34) ZZGNSUMQZJSOAK-UHFFFAOYSA-N 202797 US10245267, Example 144::US10709712, Example 144::US9242969, 144::US9694016, 144 Serine/threonine-protein kinase B-raf Homo sapiens 13.851 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202797&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409059 319495837 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359632 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cnc(OCCO)c(c1)N1CCOCC1 InChI=1S/C25H25F3N4O4/c1-16-21(18-12-22(32-5-8-35-9-6-32)24(30-14-18)36-10-7-33)13-20(15-29-16)31-23(34)17-3-2-4-19(11-17)25(26,27)28/h2-4,11-15,33H,5-10H2,1H3,(H,31,34) YQOYAEIODQJLFI-UHFFFAOYSA-N 202798 US10245267, Example 145::US10709712, Example 145::US9242969, 145::US9694016, 145 Serine/threonine-protein kinase B-raf Homo sapiens 3.786 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202798&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409579 319495838 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359633 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1c[nH]c(=O)c(c1)N1CCOCC1 InChI=1S/C24H22F3N3O3/c1-15-5-6-19(29-22(31)16-3-2-4-18(11-16)24(25,26)27)13-20(15)17-12-21(23(32)28-14-17)30-7-9-33-10-8-30/h2-6,11-14H,7-10H2,1H3,(H,28,32)(H,29,31) SBHUAUMYQMOGOC-UHFFFAOYSA-N 202799 US10245267, Example 146::US10709712, Example 146::US9242969, 146::US9694016, 146 Serine/threonine-protein kinase B-raf Homo sapiens 1.918 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202799&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122362960 319495839 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359634 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(CC#N)c1 InChI=1S/C26H23F3N4O3/c1-17-5-6-21(31-24(34)18-3-2-4-20(13-18)26(27,28)29)15-22(17)19-14-23(32-9-11-36-12-10-32)25(35)33(16-19)8-7-30/h2-6,13-16H,8-12H2,1H3,(H,31,34) GLQHXZGNENSPJX-UHFFFAOYSA-N 202800 US10245267, Example 147::US10709712, Example 147::US9242969, 147::US9694016, 147 Serine/threonine-protein kinase B-raf Homo sapiens 0.756 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202800&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408690 319495840 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359635 C[C@H](C#N)n1cc(cc(N2CCOCC2)c1=O)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C InChI=1S/C27H25F3N4O3/c1-17-6-7-22(32-25(35)19-4-3-5-21(12-19)27(28,29)30)14-23(17)20-13-24(33-8-10-37-11-9-33)26(36)34(16-20)18(2)15-31/h3-7,12-14,16,18H,8-11H2,1-2H3,(H,32,35)/t18-/m1/s1 YBVLKMMGWXPQRX-GOSISDBHSA-N 202801 US10245267, Example 148::US10709712, Example 148::US9242969, 148::US9694016, 148 Serine/threonine-protein kinase B-raf Homo sapiens 1.889 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202801&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90407964 319495841 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359636 C[C@@H](C#N)n1cc(cc(N2CCOCC2)c1=O)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C InChI=1S/C27H25F3N4O3/c1-17-6-7-22(32-25(35)19-4-3-5-21(12-19)27(28,29)30)14-23(17)20-13-24(33-8-10-37-11-9-33)26(36)34(16-20)18(2)15-31/h3-7,12-14,16,18H,8-11H2,1-2H3,(H,32,35)/t18-/m0/s1 YBVLKMMGWXPQRX-SFHVURJKSA-N 202802 US10245267, Example 149::US10709712, Example 149::US9242969, 149::US9694016, 149 Serine/threonine-protein kinase B-raf Homo sapiens 2.181 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202802&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408036 319495842 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359637 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(CCS(C)(=O)=O)c1 InChI=1S/C27H28F3N3O5S/c1-18-6-7-22(31-25(34)19-4-3-5-21(14-19)27(28,29)30)16-23(18)20-15-24(32-8-11-38-12-9-32)26(35)33(17-20)10-13-39(2,36)37/h3-7,14-17H,8-13H2,1-2H3,(H,31,34) JYESOJFCWIWKCG-UHFFFAOYSA-N 202803 US10245267, Example 150::US10709712, Example 150::US9242969, 150::US9694016, 150 Serine/threonine-protein kinase B-raf Homo sapiens 3.933 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202803&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442605 319495843 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359638 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(CCS(C)(=O)=O)c1 InChI=1S/C26H27F3N4O5S/c1-17-22(14-21(15-30-17)31-24(34)18-4-3-5-20(12-18)26(27,28)29)19-13-23(32-6-9-38-10-7-32)25(35)33(16-19)8-11-39(2,36)37/h3-5,12-16H,6-11H2,1-2H3,(H,31,34) IDNUSGHEJHHPPA-UHFFFAOYSA-N 202804 US10245267, Example 151::US10709712, Example 151::US9242969, 151::US9694016, 151 Serine/threonine-protein kinase B-raf Homo sapiens 19.733 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202804&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409060 319495844 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359639 C[C@H](Oc1ncc(cc1N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C)C#N InChI=1S/C27H25F3N4O3/c1-17-6-7-22(33-25(35)19-4-3-5-21(12-19)27(28,29)30)14-23(17)20-13-24(34-8-10-36-11-9-34)26(32-16-20)37-18(2)15-31/h3-7,12-14,16,18H,8-11H2,1-2H3,(H,33,35)/t18-/m0/s1 VXMIFMXPRCRODA-SFHVURJKSA-N 202805 US10245267, Example 152::US10709712, Example 152::US9242969, 152::US9694016, 152 Serine/threonine-protein kinase B-raf Homo sapiens 3.295 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202805&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408138 319495845 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359640 C[C@@H](Oc1ncc(cc1N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C)C#N InChI=1S/C27H25F3N4O3/c1-17-6-7-22(33-25(35)19-4-3-5-21(12-19)27(28,29)30)14-23(17)20-13-24(34-8-10-36-11-9-34)26(32-16-20)37-18(2)15-31/h3-7,12-14,16,18H,8-11H2,1-2H3,(H,33,35)/t18-/m1/s1 VXMIFMXPRCRODA-GOSISDBHSA-N 202806 US10245267, Example 153::US10709712, Example 153::US9242969, 153::US9694016, 153 Serine/threonine-protein kinase B-raf Homo sapiens 1.023 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202806&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408059 319495846 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359641 Cc1ccc(cc1-c1cc(N2CCOCC2)c(=O)n(CCS(C)(=O)=O)c1)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C27H28F3N3O5S/c1-18-6-7-19(25(34)31-22-5-3-4-21(16-22)27(28,29)30)14-23(18)20-15-24(32-8-11-38-12-9-32)26(35)33(17-20)10-13-39(2,36)37/h3-7,14-17H,8-13H2,1-2H3,(H,31,34) DLWIMHBZAQYSDZ-UHFFFAOYSA-N 202807 US10245267, Example 154::US10709712, Example 154::US9242969, 154::US9694016, 154 Serine/threonine-protein kinase B-raf Homo sapiens 7.186 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202807&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408749 319495847 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359642 CCn1cc(cc(N2CCOCC2)c1=O)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C InChI=1S/C26H26F3N3O3/c1-3-31-16-19(14-23(25(31)34)32-9-11-35-12-10-32)22-15-21(8-7-17(22)2)30-24(33)18-5-4-6-20(13-18)26(27,28)29/h4-8,13-16H,3,9-12H2,1-2H3,(H,30,33) QGKARSABKQRTLJ-UHFFFAOYSA-N 202808 US10245267, Example 155::US10709712, Example 155::US9242969, 155::US9694016, 155 Serine/threonine-protein kinase B-raf Homo sapiens 3.831 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202808&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90407897 319495848 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359643 CCOc1ncc(cc1N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C InChI=1S/C26H26F3N3O3/c1-3-35-25-23(32-9-11-34-12-10-32)14-19(16-30-25)22-15-21(8-7-17(22)2)31-24(33)18-5-4-6-20(13-18)26(27,28)29/h4-8,13-16H,3,9-12H2,1-2H3,(H,31,33) LSEPPTJNAQFEES-UHFFFAOYSA-N 202809 US10245267, Example 156::US10709712, Example 235::US9242969, 156::US9694016, 235 Serine/threonine-protein kinase B-raf Homo sapiens 2.484 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202809&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442606 319495849 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359644 CCn1cc(cc(N2CCOCC2)c1=O)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)cnc1C InChI=1S/C25H25F3N4O3/c1-3-31-15-18(12-22(24(31)34)32-7-9-35-10-8-32)21-13-20(14-29-16(21)2)30-23(33)17-5-4-6-19(11-17)25(26,27)28/h4-6,11-15H,3,7-10H2,1-2H3,(H,30,33) JWYJIGNOHJBRAT-UHFFFAOYSA-N 202810 US10245267, Example 157::US10709712, Example 157::US9242969, 157::US9694016, 157 Serine/threonine-protein kinase B-raf Homo sapiens 15.761 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202810&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90407965 319495850 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359645 CCn1cc(cc(N2CCOCC2)c1=O)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C InChI=1S/C25H25F3N4O3/c1-3-31-15-18(12-21(24(31)34)32-8-10-35-11-9-32)20-14-19(5-4-16(20)2)30-23(33)17-6-7-29-22(13-17)25(26,27)28/h4-7,12-15H,3,8-11H2,1-2H3,(H,30,33) UDVFQNCDNUGGGY-UHFFFAOYSA-N 202811 US10245267, Example 158::US10709712, Example 158::US9242969, 158::US9694016, 158 Serine/threonine-protein kinase B-raf Homo sapiens 8.383 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202811&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408274 319495851 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359646 CCOc1ncc(cc1N1CCOCC1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C InChI=1S/C25H25F3N4O3/c1-3-35-24-21(32-8-10-34-11-9-32)12-18(15-30-24)20-14-19(5-4-16(20)2)31-23(33)17-6-7-29-22(13-17)25(26,27)28/h4-7,12-15H,3,8-11H2,1-2H3,(H,31,33) YEJHEWNOBBCKFK-UHFFFAOYSA-N 202812 US10245267, Example 159::US10709712, Example 159::US9242969, 159::US9694016, 159 Serine/threonine-protein kinase B-raf Homo sapiens 2.618 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202812&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408627 319495852 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359647 CCn1cc(cc(N2CCOCC2)c1=O)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)C#N)ccc1C InChI=1S/C28H31N5O3/c1-5-32-17-21(14-24(27(32)35)33-10-12-36-13-11-33)23-16-22(7-6-19(23)2)31-26(34)20-8-9-30-25(15-20)28(3,4)18-29/h6-9,14-17H,5,10-13H2,1-4H3,(H,31,34) UJDISZKLADRITJ-UHFFFAOYSA-N 202813 US10245267, Example 160::US10709712, Example 160::US9242969, 160::US9694016, 160 Serine/threonine-protein kinase B-raf Homo sapiens 9.738 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202813&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408287 319495853 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359648 CCOc1ncc(cc1N1CCOCC1)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)C#N)ccc1C InChI=1S/C28H31N5O3/c1-5-36-27-24(33-10-12-35-13-11-33)14-21(17-31-27)23-16-22(7-6-19(23)2)32-26(34)20-8-9-30-25(15-20)28(3,4)18-29/h6-9,14-17H,5,10-13H2,1-4H3,(H,32,34) BPWZHHUEZAZOGP-UHFFFAOYSA-N 202814 US10245267, Example 161::US10709712, Example 161::US9242969, 161::US9694016, 161 Serine/threonine-protein kinase B-raf Homo sapiens 2.648 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202814&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90410117 319495854 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359649 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)n(C)c(=O)c1 InChI=1S/C25H24F3N3O3/c1-16-6-7-20(29-24(33)17-4-3-5-19(12-17)25(26,27)28)15-21(16)18-13-22(30(2)23(32)14-18)31-8-10-34-11-9-31/h3-7,12-15H,8-11H2,1-2H3,(H,29,33) OREGPRREBGYGBQ-UHFFFAOYSA-N 202815 US10245267, Example 162::US10709712, Example 162::US9242969, 162::US9694016, 162 Serine/threonine-protein kinase B-raf Homo sapiens 1.835 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202815&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408536 319495855 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359650 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)n(C)c(=O)c1 InChI=1S/C24H23F3N4O3/c1-15-20(17-11-21(30(2)22(32)12-17)31-6-8-34-9-7-31)13-19(14-28-15)29-23(33)16-4-3-5-18(10-16)24(25,26)27/h3-5,10-14H,6-9H2,1-2H3,(H,29,33) RIWOUJDVHWYDRK-UHFFFAOYSA-N 202816 US10245267, Example 163::US10709712, Example 163::US9242969, 163::US9694016, 163 Serine/threonine-protein kinase B-raf Homo sapiens 7.69 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202816&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408177 319495856 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359651 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 InChI=1S/C24H23F3N4O3/c1-15-6-7-18(28-22(32)16-4-3-5-17(12-16)24(25,26)27)13-19(15)20-14-21(23(33)30(2)29-20)31-8-10-34-11-9-31/h3-7,12-14H,8-11H2,1-2H3,(H,28,32) HSDDNNQIPLXBIA-UHFFFAOYSA-N 202817 US10245267, Example 164::US10709712, Example 164::US9242969, 164::US9694016, 164 Serine/threonine-protein kinase B-raf Homo sapiens 1.575 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202817&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409627 319495857 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359652 Cc1ccc(cc1-c1cc(N2CCOCC2)c(=O)n(C)n1)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C24H23F3N4O3/c1-15-6-7-16(22(32)28-18-5-3-4-17(13-18)24(25,26)27)12-19(15)20-14-21(23(33)30(2)29-20)31-8-10-34-11-9-31/h3-7,12-14H,8-11H2,1-2H3,(H,28,32) RXKJHRIACPQLIJ-UHFFFAOYSA-N 202818 US10245267, Example 165::US10709712, Example 165::US9242969, 165::US9694016, 653 Serine/threonine-protein kinase B-raf Homo sapiens 3.127 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202818&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90410070 319495858 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359653 Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 InChI=1S/C23H22F3N5O3/c1-14-18(19-12-20(22(33)30(2)29-19)31-6-8-34-9-7-31)11-17(13-27-14)28-21(32)15-4-3-5-16(10-15)23(24,25)26/h3-5,10-13H,6-9H2,1-2H3,(H,28,32) KPZHLNWOKWZIHG-UHFFFAOYSA-N 202819 US10245267, Example 651::US10709712, Example 166::US9242969, 166::US9694016, 651 Serine/threonine-protein kinase B-raf Homo sapiens 6.933 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202819&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408353 319495859 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359654 Cc1ncc(NC(=O)c2ccnc(c2)C(C)(C)C#N)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 InChI=1S/C25H27N7O3/c1-16-19(20-13-21(24(34)31(4)30-20)32-7-9-35-10-8-32)12-18(14-28-16)29-23(33)17-5-6-27-22(11-17)25(2,3)15-26/h5-6,11-14H,7-10H2,1-4H3,(H,29,33) LFXIIYJGGZBWBR-UHFFFAOYSA-N 202820 US10245267, Example 645::US10709712, Example 167::US9242969, 167::US9694016, 645 Serine/threonine-protein kinase B-raf Homo sapiens 106.629 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202820&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409353 319495860 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359655 Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 InChI=1S/C23H22F3N5O3/c1-14-3-4-16(28-21(32)15-5-6-27-20(11-15)23(24,25)26)12-17(14)18-13-19(22(33)30(2)29-18)31-7-9-34-10-8-31/h3-6,11-13H,7-10H2,1-2H3,(H,28,32) IYYMFWZKQUUEMP-UHFFFAOYSA-N 202821 US10245267, Example 168::US10709712, Example 168::US9242969, 168::US9694016, 658 Serine/threonine-protein kinase B-raf Homo sapiens 3.139 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202821&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442607 319495861 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359656 CCn1cc(nc(N2CCOCC2)c1=O)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C InChI=1S/C25H25F3N4O3/c1-3-31-15-21(30-22(24(31)34)32-9-11-35-12-10-32)20-14-19(8-7-16(20)2)29-23(33)17-5-4-6-18(13-17)25(26,27)28/h4-8,13-15H,3,9-12H2,1-2H3,(H,29,33) XQNRCPXMLMNNPS-UHFFFAOYSA-N 202822 US10245267, Example 169::US10709712, Example 169::US9242969, 169::US9694016, 169 Serine/threonine-protein kinase B-raf Homo sapiens 0.775 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202822&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90410080 319495862 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359657 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cn(CC(F)F)c(=O)c(n1)N1CCOCC1 InChI=1S/C25H23F5N4O3/c1-15-5-6-18(31-23(35)16-3-2-4-17(11-16)25(28,29)30)12-19(15)20-13-34(14-21(26)27)24(36)22(32-20)33-7-9-37-10-8-33/h2-6,11-13,21H,7-10,14H2,1H3,(H,31,35) PBQWRGLSSGUZOA-UHFFFAOYSA-N 202823 US10245267, Example 170::US10709712, Example 170::US9242969, 170::US9694016, 170 Serine/threonine-protein kinase B-raf Homo sapiens 1.278 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202823&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408137 319495863 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359658 Cc1ccc(NC(=O)c2cccc(c2)C(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C25H25F2N3O3/c1-16-6-7-20(28-24(31)18-5-3-4-17(12-18)23(26)27)14-21(16)19-13-22(25(32)29(2)15-19)30-8-10-33-11-9-30/h3-7,12-15,23H,8-11H2,1-2H3,(H,28,31) ISYANDALIHYXTG-UHFFFAOYSA-N 202824 US10245267, Example 171::US10709712, Example 171::US9242969, 171::US9694016, 171 Serine/threonine-protein kinase B-raf Homo sapiens 1.254 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202824&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409797 319495864 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359659 Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C28H30N4O3/c1-19-8-9-23(30-26(33)20-6-5-7-22(14-20)28(2,3)18-29)16-24(19)21-15-25(27(34)31(4)17-21)32-10-12-35-13-11-32/h5-9,14-17H,10-13H2,1-4H3,(H,30,33) ATBFVPIZYSUOTG-UHFFFAOYSA-N 202825 US10245267, Example 172::US10709712, Example 172::US9242969, 172::US9694016, 172 Serine/threonine-protein kinase B-raf Homo sapiens 2.908 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202825&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408759 319495865 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359660 CN(C)Cc1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(c1)-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C28H31F3N4O3/c1-18-5-6-23(32-26(36)20-11-19(16-33(2)3)12-22(13-20)28(29,30)31)15-24(18)21-14-25(27(37)34(4)17-21)35-7-9-38-10-8-35/h5-6,11-15,17H,7-10,16H2,1-4H3,(H,32,36) PPRLBIWEKOHUSJ-UHFFFAOYSA-N 202826 US10245267, Example 173::US10709712, Example 173::US9242969, 173::US9694016, 173 Serine/threonine-protein kinase B-raf Homo sapiens 11.8 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202826&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90407957 319495866 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359661 CCN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(c1)-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C31H36F3N5O3/c1-4-37-7-9-38(10-8-37)26-16-22(15-24(18-26)31(32,33)34)29(40)35-25-6-5-21(2)27(19-25)23-17-28(30(41)36(3)20-23)39-11-13-42-14-12-39/h5-6,15-20H,4,7-14H2,1-3H3,(H,35,40) JOXLYUZFRVVHOD-UHFFFAOYSA-N 202827 US10245267, Example 174::US10709712, Example 174::US9242969, 174::US9694016, 174 Serine/threonine-protein kinase B-raf Homo sapiens 10.049 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202827&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90407947 319495867 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359662 CN(C)c1cncc(c1)C(=O)Nc1ccc(C)c(c1)-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C25H29N5O3/c1-17-5-6-20(27-24(31)18-11-21(28(2)3)15-26-14-18)13-22(17)19-12-23(25(32)29(4)16-19)30-7-9-33-10-8-30/h5-6,11-16H,7-10H2,1-4H3,(H,27,31) FRNMUZNDLUBORX-UHFFFAOYSA-N 202828 US10245267, Example 175::US10709712, Example 175::US9242969, 175::US9694016, 175 Serine/threonine-protein kinase B-raf Homo sapiens 1.542 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202828&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408636 319495868 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359663 Cc1ccc(NC(=O)c2cc(cc(c2)S(C)(=O)=O)C(F)(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C26H26F3N3O5S/c1-16-4-5-20(30-24(33)17-10-19(26(27,28)29)13-21(11-17)38(3,35)36)14-22(16)18-12-23(25(34)31(2)15-18)32-6-8-37-9-7-32/h4-5,10-15H,6-9H2,1-3H3,(H,30,33) FFRQDGGNVABUME-UHFFFAOYSA-N 202829 US10245267, Example 176::US10709712, Example 176::US9242969, 176::US9694016, 176 Serine/threonine-protein kinase B-raf Homo sapiens 2.474 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202829&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409069 319495869 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359664 Cc1ccc(NC(=O)c2cccc(c2)C(C)(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C26H27F2N3O3/c1-17-7-8-21(29-24(32)18-5-4-6-20(13-18)26(2,27)28)15-22(17)19-14-23(25(33)30(3)16-19)31-9-11-34-12-10-31/h4-8,13-16H,9-12H2,1-3H3,(H,29,32) ZWLYLYAHGLYJPE-UHFFFAOYSA-N 202830 US10245267, Example 177::US10709712, Example 177::US9242969, 177::US9694016, 177 Serine/threonine-protein kinase B-raf Homo sapiens 0.706 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202830&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409037 319495870 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359665 Cc1ccc(NC(=O)c2ccnc(c2)C(C)(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C25H26F2N4O3/c1-16-4-5-19(29-23(32)17-6-7-28-22(13-17)25(2,26)27)14-20(16)18-12-21(24(33)30(3)15-18)31-8-10-34-11-9-31/h4-7,12-15H,8-11H2,1-3H3,(H,29,32) NBZGAVIGFGPZPW-UHFFFAOYSA-N 202831 US10245267, Example 178::US10709712, Example 178::US9242969, 178::US9694016, 178 Serine/threonine-protein kinase B-raf Homo sapiens 0.862 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202831&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408117 319495871 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359666 Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C24H23F3N4O3/c1-15-3-4-18(29-22(32)16-5-6-28-21(12-16)24(25,26)27)13-19(15)17-11-20(23(33)30(2)14-17)31-7-9-34-10-8-31/h3-6,11-14H,7-10H2,1-2H3,(H,29,32) CYQSREZKCOHNRE-UHFFFAOYSA-N 202832 US10245267, Example 179::US10709712, Example 179::US9242969, 179::US9694016, 179 Serine/threonine-protein kinase B-raf Homo sapiens 0.905 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202832&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409603 319495872 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359667 COc1ccc(cc1C(F)(F)F)C(=O)Nc1cnc(C)c(c1)-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C25H25F3N4O4/c1-15-19(17-11-21(24(34)31(2)14-17)32-6-8-36-9-7-32)12-18(13-29-15)30-23(33)16-4-5-22(35-3)20(10-16)25(26,27)28/h4-5,10-14H,6-9H2,1-3H3,(H,30,33) HTLLEJPPYZSTJI-UHFFFAOYSA-N 202833 US10245267, Example 181::US10709712, Example 181::US9242969, 181::US9694016, 181 Serine/threonine-protein kinase B-raf Homo sapiens 2.664 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202833&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408174 319495873 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359668 COc1cc(ccc1F)C(=O)Nc1cnc(C)c(c1)-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C24H25FN4O4/c1-15-19(17-10-21(24(31)28(2)14-17)29-6-8-33-9-7-29)12-18(13-26-15)27-23(30)16-4-5-20(25)22(11-16)32-3/h4-5,10-14H,6-9H2,1-3H3,(H,27,30) NEPSBBSGLKFXGR-UHFFFAOYSA-N 202834 US10245267, Example 182::US10709712, Example 182::US9242969, 182::US9694016, 182 Serine/threonine-protein kinase B-raf Homo sapiens 21.222 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202834&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408340 319495874 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359669 Cc1ccc(NC(=O)c2ccnc(c2)S(C)(=O)=O)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C24H26N4O5S/c1-16-4-5-19(26-23(29)17-6-7-25-22(13-17)34(3,31)32)14-20(16)18-12-21(24(30)27(2)15-18)28-8-10-33-11-9-28/h4-7,12-15H,8-11H2,1-3H3,(H,26,29) FSMKYSURAWMOEK-UHFFFAOYSA-N 202835 US10245267, Example 184::US10709712, Example 184::US9242969, 184::US9694016, 184 Serine/threonine-protein kinase B-raf Homo sapiens 2.202 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202835&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409107 319495875 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359670 Cc1ccc(NC(=O)c2cccc(c2)S(C)(=O)=O)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C25H27N3O5S/c1-17-7-8-20(26-24(29)18-5-4-6-21(13-18)34(3,31)32)15-22(17)19-14-23(25(30)27(2)16-19)28-9-11-33-12-10-28/h4-8,13-16H,9-12H2,1-3H3,(H,26,29) HJEAPQLJRHRRQR-UHFFFAOYSA-N 202836 US10245267, Example 185::US10709712, Example 186::US9242969, 185::US9694016, 185 Serine/threonine-protein kinase B-raf Homo sapiens 1.819 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202836&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442608 319495876 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359671 Cc1ccc(NC(=O)c2cccc(c2)C(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 InChI=1S/C24H24F2N4O3/c1-15-6-7-18(27-23(31)17-5-3-4-16(12-17)22(25)26)13-19(15)20-14-21(24(32)29(2)28-20)30-8-10-33-11-9-30/h3-7,12-14,22H,8-11H2,1-2H3,(H,27,31) GFMHYSFPEQEHTI-UHFFFAOYSA-N 202837 US10245267, Example 190::US10709712, Example 190::US9242969, 186::US9694016, 655 Serine/threonine-protein kinase B-raf Homo sapiens 2.242 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202837&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408635 319495877 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359672 Cc1ccc(NC(=O)c2ccnc(c2)C(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 InChI=1S/C23H23F2N5O3/c1-14-3-4-16(27-22(31)15-5-6-26-19(11-15)21(24)25)12-17(14)18-13-20(23(32)29(2)28-18)30-7-9-33-10-8-30/h3-6,11-13,21H,7-10H2,1-2H3,(H,27,31) MJXGSJQBDVRXKS-UHFFFAOYSA-N 202838 US10245267, Example 650::US10709712, Example 189::US9242969, 189::US9694016, 650 Serine/threonine-protein kinase B-raf Homo sapiens 4.735 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202838&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408871 319495878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359673 Cc1ccc(NC(=O)c2ccnc(c2)C(C)(C)C#N)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 InChI=1S/C26H28N6O3/c1-17-5-6-19(29-24(33)18-7-8-28-23(13-18)26(2,3)16-27)14-20(17)21-15-22(25(34)31(4)30-21)32-9-11-35-12-10-32/h5-8,13-15H,9-12H2,1-4H3,(H,29,33) LNLLSEAMZKXAPP-UHFFFAOYSA-N 202839 US10245267, Example 640::US10709712, Example 191::US9242969, 191::US9694016, 640 Serine/threonine-protein kinase B-raf Homo sapiens 9.525 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202839&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408121 319495879 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359674 Cn1cc(cc(N2CCOCC2)c1=O)-c1cc(ccc1C(F)F)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C25H22F5N3O3/c1-32-14-16(12-21(24(32)35)33-7-9-36-10-8-33)20-11-15(5-6-19(20)22(26)27)23(34)31-18-4-2-3-17(13-18)25(28,29)30/h2-6,11-14,22H,7-10H2,1H3,(H,31,34) DTQMZXFMSMGSRI-UHFFFAOYSA-N 202840 US10245267, Example 192::US10709712, Example 192::US9242969, 192::US9694016, 192 Serine/threonine-protein kinase B-raf Homo sapiens 33.857 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202840&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409411 319495880 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359675 COC(=O)NCCn1cc(cc(N2CCOCC2)c1=O)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)cnc1C InChI=1S/C27H28F3N5O5/c1-17-22(14-21(15-32-17)33-24(36)18-4-3-5-20(12-18)27(28,29)30)19-13-23(34-8-10-40-11-9-34)25(37)35(16-19)7-6-31-26(38)39-2/h3-5,12-16H,6-11H2,1-2H3,(H,31,38)(H,33,36) LYWNHHSMUZTLKZ-UHFFFAOYSA-N 202841 US10245267, Example 193::US10709712, Example 193::US9242969, 193::US9694016, 193 Serine/threonine-protein kinase B-raf Homo sapiens 105.813 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202841&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442610 319495881 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359676 COC(=O)NCCn1cc(cc(N2CCOCC2)c1=O)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C InChI=1S/C28H29F3N4O5/c1-18-6-7-22(33-25(36)19-4-3-5-21(14-19)28(29,30)31)16-23(18)20-15-24(34-10-12-40-13-11-34)26(37)35(17-20)9-8-32-27(38)39-2/h3-7,14-17H,8-13H2,1-2H3,(H,32,38)(H,33,36) KFFCNUUBQXOSPH-UHFFFAOYSA-N 202842 US10245267, Example 194::US10709712, Example 194::US9242969, 194::US9694016, 194 Serine/threonine-protein kinase B-raf Homo sapiens 12.407 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202842&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442609 319495882 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359677 COc1cc(nc(c1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C)N1CCOCC1 InChI=1S/C25H24F3N3O3/c1-16-6-7-19(29-24(32)17-4-3-5-18(12-17)25(26,27)28)13-21(16)22-14-20(33-2)15-23(30-22)31-8-10-34-11-9-31/h3-7,12-15H,8-11H2,1-2H3,(H,29,32) DCKPXKUYFVTZND-UHFFFAOYSA-N 202843 US10245267, Example 196::US10709712, Example 196::US9242969, 196::US9694016, 196 Serine/threonine-protein kinase B-raf Homo sapiens 2.191 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202843&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409058 319495883 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359678 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(=O)cc([nH]1)N1CCOCC1 InChI=1S/C24H22F3N3O3/c1-15-5-6-18(28-23(32)16-3-2-4-17(11-16)24(25,26)27)12-20(15)21-13-19(31)14-22(29-21)30-7-9-33-10-8-30/h2-6,11-14H,7-10H2,1H3,(H,28,32)(H,29,31) WWBHJFPEMPJRTI-UHFFFAOYSA-N 202844 US9242969, 197 Serine/threonine-protein kinase B-raf Homo sapiens 6.733 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202844&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127053725 319495884 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359679 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)c2nccn2n1 InChI=1S/C25H22F3N5O2/c1-16-5-6-19(30-24(34)17-3-2-4-18(13-17)25(26,27)28)14-20(16)21-15-22(32-9-11-35-12-10-32)23-29-7-8-33(23)31-21/h2-8,13-15H,9-12H2,1H3,(H,30,34) DAPUTCXAHDOMMA-UHFFFAOYSA-N 202847 US10245267, Example 831::US10709712, Example 200::US9242969, 200::US9694016, 831 Serine/threonine-protein kinase B-raf Homo sapiens 1.538 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202847&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442616 319495887 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359680 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CC3CC(C2)O3)c(=O)n(C)c1 InChI=1S/C26H24F3N3O3/c1-15-6-7-19(30-24(33)16-4-3-5-18(8-16)26(27,28)29)10-22(15)17-9-23(25(34)31(2)12-17)32-13-20-11-21(14-32)35-20/h3-10,12,20-21H,11,13-14H2,1-2H3,(H,30,33) GYEBSMWPNKRNAF-UHFFFAOYSA-N 202848 US10245267, Example 464::US10709712, Example 201::US9242969, 201::US9694016, 464 Serine/threonine-protein kinase B-raf Homo sapiens 14.467 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202848&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442617 319495888 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359681 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc2nccn2c(n1)N1CCOCC1 InChI=1S/C25H22F3N5O2/c1-16-5-6-19(30-23(34)17-3-2-4-18(13-17)25(26,27)28)14-20(16)21-15-22-29-7-8-33(22)24(31-21)32-9-11-35-12-10-32/h2-8,13-15H,9-12H2,1H3,(H,30,34) CDBQKPKEEIZUOR-UHFFFAOYSA-N 202849 US10245267, Example 828::US10709712, Example 202::US9242969, 202::US9694016, 828 Serine/threonine-protein kinase B-raf Homo sapiens 0.941 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202849&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442618 319495889 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359682 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cn2ccnc2c(n1)N1CCOCC1 InChI=1S/C25H22F3N5O2/c1-16-5-6-19(30-24(34)17-3-2-4-18(13-17)25(26,27)28)14-20(16)21-15-33-8-7-29-22(33)23(31-21)32-9-11-35-12-10-32/h2-8,13-15H,9-12H2,1H3,(H,30,34) QUBAZPBETZNQAE-UHFFFAOYSA-N 202850 US10245267, Example 824::US10709712, Example 203::US9242969, 203::US9694016, 824 Serine/threonine-protein kinase B-raf Homo sapiens 0.389 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202850&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442619 319495890 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359683 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1nc(N2CCOCC2)c2sccc2n1 InChI=1S/C25H21F3N4O2S/c1-15-5-6-18(29-24(33)16-3-2-4-17(13-16)25(26,27)28)14-19(15)22-30-20-7-12-35-21(20)23(31-22)32-8-10-34-11-9-32/h2-7,12-14H,8-11H2,1H3,(H,29,33) FKUBKOPNAZUGDL-UHFFFAOYSA-N 202851 US10245267, Example 829::US10709712, Example 204::US9242969, 204::US9694016, 829 Serine/threonine-protein kinase B-raf Homo sapiens 0.152 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202851&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442620 319495891 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359684 C[C@@H]1COCCN1c1nc(cn2ccnc12)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C InChI=1S/C26H24F3N5O2/c1-16-6-7-20(31-25(35)18-4-3-5-19(12-18)26(27,28)29)13-21(16)22-14-33-9-8-30-23(33)24(32-22)34-10-11-36-15-17(34)2/h3-9,12-14,17H,10-11,15H2,1-2H3,(H,31,35)/t17-/m1/s1 XWQFRYNHIVMONA-QGZVFWFLSA-N 202852 US10245267, Example 825::US10709712, Example 205::US9242969, 205::US9694016, 825 Serine/threonine-protein kinase B-raf Homo sapiens 1.286 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202852&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442621 319495892 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359685 Cc1ccc(NC(=O)c2ccnc(c2)C(C)(C)C#N)cc1-c1cc2[nH]cnc2c(n1)N1CCOCC1 InChI=1S/C27H27N7O2/c1-17-4-5-19(32-26(35)18-6-7-29-23(12-18)27(2,3)15-28)13-20(17)21-14-22-24(31-16-30-22)25(33-21)34-8-10-36-11-9-34/h4-7,12-14,16H,8-11H2,1-3H3,(H,30,31)(H,32,35) QCRIYJQIMJIEQT-UHFFFAOYSA-N 202853 US10709712, Example 206::US9242969, 206 Serine/threonine-protein kinase B-raf Homo sapiens 9.218 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202853&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442622 319495893 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359686 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)c2oc(=O)[nH]c2c1 InChI=1S/C26H22F3N3O4/c1-15-5-6-19(30-24(33)16-3-2-4-18(11-16)26(27,28)29)14-20(15)17-12-21-23(36-25(34)31-21)22(13-17)32-7-9-35-10-8-32/h2-6,11-14H,7-10H2,1H3,(H,30,33)(H,31,34) ZQVAYYPNZFAWMA-UHFFFAOYSA-N 202854 US10245267, Example 826::US10709712, Example 207::US9242969, 207 Serine/threonine-protein kinase B-raf Homo sapiens 1.399 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202854&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90445503 319495894 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359687 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(cc2[nH]c(=O)oc12)N1CCOCC1 InChI=1S/C26H22F3N3O4/c1-15-5-6-18(30-24(33)16-3-2-4-17(11-16)26(27,28)29)12-20(15)21-13-19(32-7-9-35-10-8-32)14-22-23(21)36-25(34)31-22/h2-6,11-14H,7-10H2,1H3,(H,30,33)(H,31,34) NSUYTCKRYLDDHP-UHFFFAOYSA-N 202855 US10709712, Example 826::US9242969, 208::US9694016, 826 Serine/threonine-protein kinase B-raf Homo sapiens 5.048 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202855&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442625 319495895 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359688 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc2[nH]cnc2c(n1)N1CCOCC1 InChI=1S/C25H22F3N5O2/c1-15-5-6-18(31-24(34)16-3-2-4-17(11-16)25(26,27)28)12-19(15)20-13-21-22(30-14-29-21)23(32-20)33-7-9-35-10-8-33/h2-6,11-14H,7-10H2,1H3,(H,29,30)(H,31,34) SIPHDDWBTBYNTO-UHFFFAOYSA-N 202856 US10709712, Example 209::US9242969, 209 Serine/threonine-protein kinase B-raf Homo sapiens 1.067 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202856&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442627 319495896 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359689 C[C@@H]1COCCN1c1nc(cc2[nH]cnc12)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)C#N)ccc1C 202857 US10709712, Example 858::US9242969, 210::US9694016, 858 Serine/threonine-protein kinase B-raf Homo sapiens 22.094 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202857&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442626 319495897 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359690 C[C@@H]1COCCN1c1nc(cc2[nH]cnc12)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C 202858 US10245267, Example 811::US10709712, Example 811::US9242969, 211::US9694016, 811 Serine/threonine-protein kinase B-raf Homo sapiens 6.261 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202858&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442624 319495898 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359691 Cc1ncc(NC(=O)c2cc(cc(c2)S(C)(=O)=O)C(F)(F)F)cc1-c1ccnc(c1)N1CCOCC1 InChI=1S/C24H23F3N4O4S/c1-15-21(16-3-4-28-22(11-16)31-5-7-35-8-6-31)13-19(14-29-15)30-23(32)17-9-18(24(25,26)27)12-20(10-17)36(2,33)34/h3-4,9-14H,5-8H2,1-2H3,(H,30,32) KVWUPLZRKBYTGG-UHFFFAOYSA-N 202860 US10709712, Example 214::US9242969, 214 Serine/threonine-protein kinase B-raf Homo sapiens 4.83 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202860&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90442628 319495899 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359692 Cc1ccc(NC(=O)c2ccnc(c2)C(F)F)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 InChI=1S/C24H24F2N4O3/c1-15-3-4-18(28-23(31)16-5-6-27-20(11-16)22(25)26)13-19(15)17-12-21(24(32)29(2)14-17)30-7-9-33-10-8-30/h3-6,11-14,22H,7-10H2,1-2H3,(H,28,31) YZFGUJDSWAIDIF-UHFFFAOYSA-N 202861 US10245267, Example 358::US10709712, Example 215::US9242969, 215::US9694016, 215 Serine/threonine-protein kinase B-raf Homo sapiens 7.267 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202861&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90409527 319495900 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 359693 CCN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(c1)-c1ccnc(c1)N1CCOCC1 InChI=1S/C30H34F3N5O2/c1-3-36-8-10-37(11-9-36)26-17-23(16-24(19-26)30(31,32)33)29(39)35-25-5-4-21(2)27(20-25)22-6-7-34-28(18-22)38-12-14-40-15-13-38/h4-7,16-20H,3,8-15H2,1-2H3,(H,35,39) QVRGGLLSYRKKJZ-UHFFFAOYSA-N 202865 US10245267, Example 74::US10709712, Example 74::US9242969, 219::US9694016, 74 Serine/threonine-protein kinase B-raf Homo sapiens 2.834 7.5 25.00 C US Patent 10.7270/Q2VT1QXT aid1802160 US9242969 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202865&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90408857 319495901 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 364060 CSc1nc(N)cc(Oc2ccc(cc2)-c2nnc(Nc3cccc(c3)C(F)(F)F)[nH]2)n1 InChI=1S/C20H16F3N7OS/c1-32-19-26-15(24)10-16(27-19)31-14-7-5-11(6-8-14)17-28-18(30-29-17)25-13-4-2-3-12(9-13)20(21,22)23/h2-10H,1H3,(H2,24,26,27)(H2,25,28,29,30) CMYHZFCJPORPHY-UHFFFAOYSA-N 205483 US9260417, 6 Serine/threonine-protein kinase B-raf Homo sapiens >10000 US Patent 10.7270/Q270807Z aid1802221 US9260417 Murphy, EA; Cheresh, DA; Arnold, LD AMITECH THERAPEUTIC SOLUTIONS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=205483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=205483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53328059 321901072 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371254 O=C1CCc2c(Oc3ccc4CC5C(C5c4c3)c3nc4ccccc4[nH]3)ccnc2N1 210034 US10576087, Compound 1.1::US9273046, 1.1::US9895376, Compound 1.1 Serine/threonine-protein kinase B-raf Homo sapiens 11 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210034&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71622663 329586273 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371255 FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Cc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210035 US10576087, Compound 1.2::US9273046, 1.2::US9895376, Compound 1.2 Serine/threonine-protein kinase B-raf Homo sapiens 72 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210035&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71622802 329586274 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371256 O=C1CCc2c(Oc3ccc4CC5C(C5c4c3)c3nc4ccccc4s3)ccnc2N1 InChI=1S/C25H19N3O2S/c29-21-8-7-15-19(9-10-26-24(15)28-21)30-14-6-5-13-11-17-22(16(13)12-14)23(17)25-27-18-3-1-2-4-20(18)31-25/h1-6,9-10,12,17,22-23H,7-8,11H2,(H,26,28,29) IXJJQTYDLOSUBW-UHFFFAOYSA-N 210036 US10576087, Compound 1.3::US9273046, 1.3 Serine/threonine-protein kinase B-raf Homo sapiens 88 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210036&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71622798 329586275 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371257 O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccccc4[nH]3)ccnc2N1 210037 US10576087, Compound 2.1::US9273046, 2.1::US9895376, Compound 2.1 Serine/threonine-protein kinase B-raf Homo sapiens 3.1 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210037&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71622799 329586276 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371258 FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210038 US10576087, Compound 2.2::US9273046, 2.2::US9895376, Compound 2.2 Serine/threonine-protein kinase B-raf Homo sapiens 7.2 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210038&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71622942 329586277 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371259 FC(F)(F)c1ccc2nc([nH]c2c1)C1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 210039 US9273046, 2.2a Serine/threonine-protein kinase B-raf Homo sapiens 6.7 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210039&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89670175 329586278 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371260 FC(F)(F)c1ccc2nc([nH]c2c1)C1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12 210040 US9273046, 2.2b Serine/threonine-protein kinase B-raf Homo sapiens 53 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210040&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 124081230 329586279 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371261 Clc1cc2nc([nH]c2cc1Cl)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210041 US10576087, Compound 2.3::US9273046, 2.3::US9895376, Compound 2.3 Serine/threonine-protein kinase B-raf Homo sapiens 32 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210041&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71622800 329586280 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371262 Clc1cc2nc([nH]c2cc1Cl)C1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12 210042 US9273046, 2.3a Serine/threonine-protein kinase B-raf Homo sapiens 11 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210042&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 124081231 329586281 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371263 Clc1cc2nc([nH]c2cc1Cl)C1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 210043 US9273046, 2.3b Serine/threonine-protein kinase B-raf Homo sapiens 32 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210043&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 124081232 329586282 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371264 Cc1cc2[nH]c(nc2cc1F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210044 US10576087, Compound 2.4::US9273046, 2.4::US9895376, Compound 2.4 Serine/threonine-protein kinase B-raf Homo sapiens 2.4 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210044&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71622943 329586283 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371265 Cc1cc2[nH]c(nc2cc1F)C1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12 210045 US9273046, 2.4a Serine/threonine-protein kinase B-raf Homo sapiens 3.4 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210045&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 124081233 329586284 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371266 Cc1cc2[nH]c(nc2cc1F)C1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 210046 US9273046, 2.4b Serine/threonine-protein kinase B-raf Homo sapiens 21 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210046&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 124081234 329586285 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371267 FC(F)(F)c1cc2[nH]c(nc2cc1Cl)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210047 US10576087, Compound 2.5::US9273046, 2.5::US9895376, Compound 2.5 Serine/threonine-protein kinase B-raf Homo sapiens 19 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210047&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71622801 329586286 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371268 FC(F)(F)c1cc2[nH]c(nc2cc1Cl)C1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12 210048 US9273046, 2.5a Serine/threonine-protein kinase B-raf Homo sapiens 126 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210048&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 124081235 329586287 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371269 FC(F)(F)c1cc2[nH]c(nc2cc1Cl)C1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 210049 US9273046, 2.5b Serine/threonine-protein kinase B-raf Homo sapiens 11 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210049&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 124081236 329586288 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371270 O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccc(cc4[nH]3)C#N)ccnc2N1 210000 US10576087, Compound 2.6::US9273046, 2.6::US9895376, Compound 2.6 Serine/threonine-protein kinase B-raf Homo sapiens 22 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210000&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71622944 329586239 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371271 Fc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210001 US10576087, Compound 2.7::US9273046, 2.7::US9895376, Compound 2.7 Serine/threonine-protein kinase B-raf Homo sapiens 10 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210001&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71622945 329586240 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371272 Cc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210002 US10576087, Compound 2.8::US9273046, 2.8::US9895376, Compound 2.8 Serine/threonine-protein kinase B-raf Homo sapiens 3.7 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210002&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71620741 329586241 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371273 O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccncc4[nH]3)ccnc2N1 210003 US10576087, Compound 2.9::US9273046, 2.9::US9895376, Compound 2.9 Serine/threonine-protein kinase B-raf Homo sapiens 42 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210003&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71622946 329586242 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371274 FC(F)(F)c1cc(Cl)c2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210004 US10576087, Compound 2.10::US9273046, 2.10::US9895376, Compound 2.10 Serine/threonine-protein kinase B-raf Homo sapiens 80 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210004&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71620742 329586243 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371275 Fc1cc2nc([nH]c2cc1F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210005 US10576087, Compound 2.11::US9273046, 2.11::US9895376, Compound 2.11 Serine/threonine-protein kinase B-raf Homo sapiens 5.9 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210005&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71622947 329586244 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371276 Clc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210006 US10576087, Compound 2.12::US9273046, 2.12::US9895376, Compound 2.12 Serine/threonine-protein kinase B-raf Homo sapiens 12 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210006&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621691 329586245 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371277 Brc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210007 US10576087, Compound 2.13::US9273046, 2.13::US9895376, Compound 2.28 Serine/threonine-protein kinase B-raf Homo sapiens 7.2 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210007&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71620739 329586246 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371278 FC(F)(F)Oc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210008 US10576087, Compound 2.14::US9273046, 2.14::US9895376, Compound 2.14 Serine/threonine-protein kinase B-raf Homo sapiens 28 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210008&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71620743 329586247 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371279 Cn1c(nc2ccccc12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 InChI=1S/C25H20N4O3/c1-29-17-5-3-2-4-16(17)27-25(29)22-21-15-12-13(6-8-18(15)32-23(21)22)31-19-10-11-26-24-14(19)7-9-20(30)28-24/h2-6,8,10-12,21-23H,7,9H2,1H3,(H,26,28,30) HJYUNCUCFSUWLN-UHFFFAOYSA-N 210009 US10576087, Compound 2.15::US9273046, 2.15::US9895376, Compound 2.15 Serine/threonine-protein kinase B-raf Homo sapiens 12 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210009&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71620740 329586248 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371280 COc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210010 US10576087, Compound 2.16::US9273046, 2.16::US9895376, Compound 2.16 Serine/threonine-protein kinase B-raf Homo sapiens 15 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210010&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71620889 329586249 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371281 Fc1cc2[nH]c(nc2cc1Cl)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210011 US10576087, Compound 2.17::US9273046, 2.17::US9895376, Compound 2.17 Serine/threonine-protein kinase B-raf Homo sapiens 5.4 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210011&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71620890 329586250 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371282 FC(F)(F)c1cccc2nc([nH]c12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210012 US10576087, Compound 2.18::US9273046, 2.18::US9895376, Compound 2.18 Serine/threonine-protein kinase B-raf Homo sapiens 89 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210012&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621045 329586251 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371283 Fc1cccc2nc([nH]c12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210013 US10576087, Compound 2.19::US9273046, 2.19::US9895376, Compound 2.19 Serine/threonine-protein kinase B-raf Homo sapiens 11 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210013&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71620891 329586252 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371284 CC(C)(C)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210014 US10576087, Compound 2.20::US9273046, 2.20::US9895376, Compound 2.20 Serine/threonine-protein kinase B-raf Homo sapiens 33 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210014&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621046 329586253 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371285 O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4cc5CCCc5cc4[nH]3)ccnc2N1 210015 US10576087, Compound 2.21::US9273046, 2.21::US9895376, Compound 2.21 Serine/threonine-protein kinase B-raf Homo sapiens 1.2 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210015&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71598638 329586254 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371286 NC(=O)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210016 US10576087, Compound 2.22::US9273046, 2.22::US9895376, Compound 2.22 Serine/threonine-protein kinase B-raf Homo sapiens 4 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210016&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621047 329586255 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371287 Cn1c(nc2ccc(cc12)C(F)(F)F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 InChI=1S/C26H19F3N4O3/c1-33-17-10-12(26(27,28)29)2-5-16(17)31-25(33)22-21-15-11-13(3-6-18(15)36-23(21)22)35-19-8-9-30-24-14(19)4-7-20(34)32-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,30,32,34) PGUXNNCLFWKXCV-UHFFFAOYSA-N 210017 US10576087, Compound 2.23::US9273046, 2.23::US9895376, Compound 2.23 Serine/threonine-protein kinase B-raf Homo sapiens 204 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210017&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71620892 329586256 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371288 Cn1c(nc2cc(ccc12)C(F)(F)F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 InChI=1S/C26H19F3N4O3/c1-33-17-5-2-12(26(27,28)29)10-16(17)31-25(33)22-21-15-11-13(3-6-18(15)36-23(21)22)35-19-8-9-30-24-14(19)4-7-20(34)32-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,30,32,34) NGJLJBKZMQQHLQ-UHFFFAOYSA-N 210018 US10576087, Compound 2.24::US9273046, 2.24::US9895376, Compound 2.24 Serine/threonine-protein kinase B-raf Homo sapiens 47 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210018&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621048 329586257 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371289 FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3c(cccc3Oc3ccnc4NC(=O)CCc34)C12 210019 US10576087, Compound 2.25::US9273046, 2.25::US9895376, Compound 2.25 Serine/threonine-protein kinase B-raf Homo sapiens 849 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210019&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71620893 329586258 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371290 Clc1cccc2nc([nH]c12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210020 US10576087, Compound 2.26::US9273046, 2.26::US9895376, Compound 2.26 Serine/threonine-protein kinase B-raf Homo sapiens 16 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210020&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621049 329586259 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371291 Oc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210021 US10576087, Compound 2.27::US9273046, 2.27::US9895376, Compound 2.27 Serine/threonine-protein kinase B-raf Homo sapiens 2.5 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210021&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621201 329586260 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371292 O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccc(cc4[nH]3)-c3ccccc3)ccnc2N1 210050 US10576087, Compound 2.28::US9273046, 2.28 Serine/threonine-protein kinase B-raf Homo sapiens 232 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210050&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89670211 329586289 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371293 O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc(no3)-c3ccccc3)ccnc2N1 InChI=1S/C25H18N4O4/c30-19-9-7-15-18(10-11-26-24(15)27-19)31-14-6-8-17-16(12-14)20-21(22(20)32-17)25-28-23(29-33-25)13-4-2-1-3-5-13/h1-6,8,10-12,20-22H,7,9H2,(H,26,27,30) IBODLCSYFMEGAG-UHFFFAOYSA-N 210051 US10576087, Compound 2.29::US9273046, 2.29::US9895376, Compound 2.29 Serine/threonine-protein kinase B-raf Homo sapiens 3.2 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210051&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621202 329586290 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371294 O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1 210052 US10576087, Compound 2.30::US9273046, 2.30 Serine/threonine-protein kinase B-raf Homo sapiens 0.72 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210052&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621371 329586291 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371295 O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc(c[nH]3)-c3ccncc3)ccnc2N1 210022 US10576087, Compound 2.31::US9273046, 2.31::US9895376, Compound 2.31 Serine/threonine-protein kinase B-raf Homo sapiens 3.7 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210022&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621203 329586261 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371296 Clc1ccccc1-c1c[nH]c(n1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210023 US10576087, Compound 2.32::US9273046, 2.32::US9895376, Compound 2.32 Serine/threonine-protein kinase B-raf Homo sapiens 3.3 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210023&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621372 329586262 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371297 FC(F)(F)c1c[nH]c(n1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 210024 US10576087, Compound 2.33::US9273046, 2.33::US9895376, Compound 2.33 Serine/threonine-protein kinase B-raf Homo sapiens 6 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210024&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621204 329586263 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371298 OCCn1c(nc2cc(ccc12)C(F)(F)F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 InChI=1S/C27H21F3N4O4/c28-27(29,30)13-1-4-18-17(11-13)32-26(34(18)9-10-35)23-22-16-12-14(2-5-19(16)38-24(22)23)37-20-7-8-31-25-15(20)3-6-21(36)33-25/h1-2,4-5,7-8,11-12,22-24,35H,3,6,9-10H2,(H,31,33,36) KLZJZIQBYPVAEM-UHFFFAOYSA-N 210025 US10576087, Compound 2.34::US9273046, 2.34::US9895376, Compound 2.34 Serine/threonine-protein kinase B-raf Homo sapiens 30 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210025&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621373 329586264 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371299 Cc1cc(Oc2ccnc3NC(=O)CCc23)cc2C3C(Oc12)C3c1nc2ccc(cc2[nH]1)C(F)(F)F 210057 US10576087, Compound 2.35::US9273046, 2.35::US9895376, Compound 2.35 Serine/threonine-protein kinase B-raf Homo sapiens 61 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210057&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621205 329586296 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371300 FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3cc(Cl)c(Oc4ccnc5NC(=O)CCc45)cc3C12 210026 US10576087, Compound 2.36::US9273046, 2.36::US9895376, Compound 2.36 Serine/threonine-protein kinase B-raf Homo sapiens 117 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210026&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621523 329586265 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371301 Cc1cc2nc([nH]c2cc1F)C1C2Oc3cc(Cl)c(Oc4ccnc5NC(=O)CCc45)cc3C12 210027 US10576087, Compound 2.37::US9273046, 2.37::US9895376, Compound 2.37 Serine/threonine-protein kinase B-raf Homo sapiens 173 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210027&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621369 329586266 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371302 CNC(=O)c1cc(Oc2ccc3OC4C(C4c3c2)c2nc3ccc(cc3[nH]2)C(F)(F)F)ccn1 210028 US10576087, Compound 3.1::US9273046, 3.1 Serine/threonine-protein kinase B-raf Homo sapiens 56 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210028&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621524 329586267 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371303 FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccncn4)cc3C12 210031 US10576087, Compound 3.2::US9273046, 3.2::US9895376, Compound 3.2 Serine/threonine-protein kinase B-raf Homo sapiens 569 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210031&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621687 329586270 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371304 FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5[nH]ccc45)cc3C12 210029 US10576087, Compound 3.3::US9273046, 3.3 Serine/threonine-protein kinase B-raf Homo sapiens 522 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210029&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621525 329586268 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371305 FC(F)(F)c1c[nH]c(n1)-c1cc(Oc2ccc3OC4C(C4c3c2)c2nc3ccc(cc3[nH]2)C(F)(F)F)ccn1 210030 US10576087, Compound 3.4::US9273046, 3.4::US9895376, Compound 3.4 Serine/threonine-protein kinase B-raf Homo sapiens 291 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210030&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621688 329586269 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371306 FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ncnc5[nH]cnc45)cc3C12 210053 US10576087, Compound 3.5::US9273046, 3.5::US9895376, Compound 3.5 Serine/threonine-protein kinase B-raf Homo sapiens 56 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210053&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621526 329586292 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371307 FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccncc4)cc3C12 210054 US10576087, Compound 3.6::US9273046, 3.6::US9895376, Compound 3.6 Serine/threonine-protein kinase B-raf Homo sapiens 518 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210054&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621689 329586293 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371308 FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)OCc45)cc3C12 210032 US10576087, Compound 3.7::US9273046, 3.7::US9895376, Compound 3.7 Serine/threonine-protein kinase B-raf Homo sapiens 26 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210032&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621527 329586271 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371309 FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4c(Cl)cnc5NC(=O)CCc45)cc3C12 210033 US10576087, Compound 3.8::US9273046, 3.8::US9895376, Compound 3.8 Serine/threonine-protein kinase B-raf Homo sapiens >1000 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210033&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71621690 329586272 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371310 OC(=O)C1C2Cc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 InChI=1S/C19H16N2O4/c22-15-4-3-11-14(5-6-20-18(11)21-15)25-10-2-1-9-7-13-16(12(9)8-10)17(13)19(23)24/h1-2,5-6,8,13,16-17H,3-4,7H2,(H,23,24)(H,20,21,22) VNKAEQGZYPEZJH-UHFFFAOYSA-N 210055 US10576087, Compound Intermediate I::US9273046, Intermediate I::US9895376, Compound Intermediate I Serine/threonine-protein kinase B-raf Homo sapiens >5000 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210055&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89670169 329586294 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 371311 OC(=O)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 InChI=1S/C18H14N2O5/c21-13-4-2-9-12(5-6-19-17(9)20-13)24-8-1-3-11-10(7-8)14-15(18(22)23)16(14)25-11/h1,3,5-7,14-16H,2,4H2,(H,22,23)(H,19,20,21) DFGSAHDXAISKIW-UHFFFAOYSA-N 210056 US10576087, Compound Intermediate II::US9273046, Intermediate II::US9895376, Compound Intermediate-II Serine/threonine-protein kinase B-raf Homo sapiens >5000 25.00 C US Patent 10.7270/Q28G8JK6 aid1802347 US9273046 Zhou, C; Wang, S; Zhang, G BeiGene, Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210056&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89670176 329586295 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373831 CN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C27H32N8O2/c1-18-6-7-19(26(36)29-25-14-24(37-31-25)27(2,3)4)13-23(18)35-17-22(30-32-35)20-12-21(16-28-15-20)34-10-8-33(5)9-11-34/h6-7,12-17H,8-11H2,1-5H3,(H,29,31,36) DRRAGFXUNAAEDE-UHFFFAOYSA-N 212281 US9290507, I-1 Serine/threonine-protein kinase B-raf Homo sapiens 8 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212281&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464406 329588145 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373832 CN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(C)(C)C InChI=1S/C29H34N8O/c1-20-6-7-21(28(38)32-27-16-23(8-9-31-27)29(2,3)4)15-26(20)37-19-25(33-34-37)22-14-24(18-30-17-22)36-12-10-35(5)11-13-36/h6-9,14-19H,10-13H2,1-5H3,(H,31,32,38) GMZSESCROBYEBD-UHFFFAOYSA-N 212282 US9290507, I-2 Serine/threonine-protein kinase B-raf Homo sapiens 18 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212282&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464407 329588146 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373833 CN(C)CCN(C)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C27H34N8O2/c1-18-8-9-19(26(36)29-25-14-24(37-31-25)27(2,3)4)13-23(18)35-17-22(30-32-35)20-12-21(16-28-15-20)34(7)11-10-33(5)6/h8-9,12-17H,10-11H2,1-7H3,(H,29,31,36) CXOSOTCBVOKHGH-UHFFFAOYSA-N 212283 US9290507, I-3 Serine/threonine-protein kinase B-raf Homo sapiens 7 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212283&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464466 329588147 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373834 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCN(CC1)C(C)(C)C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C30H38N8O2/c1-20-8-9-21(28(39)32-27-16-26(40-34-27)29(2,3)4)15-25(20)38-19-24(33-35-38)22-14-23(18-31-17-22)36-10-12-37(13-11-36)30(5,6)7/h8-9,14-19H,10-13H2,1-7H3,(H,32,34,39) TUCUDNSITLYEKY-UHFFFAOYSA-N 212284 US9290507, I-4 Serine/threonine-protein kinase B-raf Homo sapiens 12 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212284&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464467 329588148 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373835 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCN(CC1)C1CCCC1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C31H38N8O2/c1-21-9-10-22(30(40)33-29-17-28(41-35-29)31(2,3)4)16-27(21)39-20-26(34-36-39)23-15-25(19-32-18-23)38-13-11-37(12-14-38)24-7-5-6-8-24/h9-10,15-20,24H,5-8,11-14H2,1-4H3,(H,33,35,40) URSMWTJTEYWXSV-UHFFFAOYSA-N 212285 US9290507, I-5 Serine/threonine-protein kinase B-raf Homo sapiens 14 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212285&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464468 329588149 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373836 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCN(CC=C)CC1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C29H34N8O2/c1-6-9-35-10-12-36(13-11-35)23-14-22(17-30-18-23)24-19-37(34-32-24)25-15-21(8-7-20(25)2)28(38)31-27-16-26(39-33-27)29(3,4)5/h6-8,14-19H,1,9-13H2,2-5H3,(H,31,33,38) OVRODBLVXQDSSU-UHFFFAOYSA-N 212286 US9290507, I-6 Serine/threonine-protein kinase B-raf Homo sapiens 22 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212286&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464469 329588150 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373837 CCN1CCC2(CCN(C2)c2cncc(c2)-c2cn(nn2)-c2cc(ccc2C)C(=O)Nc2cc(on2)C(C)(C)C)C1 InChI=1S/C31H38N8O2/c1-6-37-11-9-31(19-37)10-12-38(20-31)24-13-23(16-32-17-24)25-18-39(36-34-25)26-14-22(8-7-21(26)2)29(40)33-28-15-27(41-35-28)30(3,4)5/h7-8,13-18H,6,9-12,19-20H2,1-5H3,(H,33,35,40) ZZLUXQUEHOMEDV-UHFFFAOYSA-N 212287 US9290507, I-7 Serine/threonine-protein kinase B-raf Homo sapiens 9 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212287&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464470 329588151 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373838 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCN(CC2CCCO2)CC1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C31H38N8O3/c1-21-7-8-22(30(40)33-29-16-28(42-35-29)31(2,3)4)15-27(21)39-20-26(34-36-39)23-14-24(18-32-17-23)38-11-9-37(10-12-38)19-25-6-5-13-41-25/h7-8,14-18,20,25H,5-6,9-13,19H2,1-4H3,(H,33,35,40) YWNSBCVDFMGTEF-UHFFFAOYSA-N 212288 US9290507, I-8 Serine/threonine-protein kinase B-raf Homo sapiens 22 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212288&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464529 329588152 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373839 CN(C)CC1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C30H38N8O2/c1-20-7-8-22(29(39)32-28-15-27(40-34-28)30(2,3)4)14-26(20)38-19-25(33-35-38)23-13-24(17-31-16-23)37-11-9-21(10-12-37)18-36(5)6/h7-8,13-17,19,21H,9-12,18H2,1-6H3,(H,32,34,39) NDWPFNZZWDYAPN-UHFFFAOYSA-N 212289 US9290507, I-9 Serine/threonine-protein kinase B-raf Homo sapiens 12 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212289&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464530 329588153 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373840 CN(C1CCOC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C27H31N7O3/c1-17-6-7-18(26(35)29-25-12-24(37-31-25)27(2,3)4)11-23(17)34-15-22(30-32-34)19-10-21(14-28-13-19)33(5)20-8-9-36-16-20/h6-7,10-15,20H,8-9,16H2,1-5H3,(H,29,31,35) VUVJZAGCIKDPQH-UHFFFAOYSA-N 212290 US9290507, I-10 Serine/threonine-protein kinase B-raf Homo sapiens 8 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212290&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464531 329588154 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373841 Cc1ccc(cc1-n1cc(nn1)-c1cncc(NC2CCOC2)c1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C26H29N7O3/c1-16-5-6-17(25(34)29-24-11-23(36-31-24)26(2,3)4)10-22(16)33-14-21(30-32-33)18-9-20(13-27-12-18)28-19-7-8-35-15-19/h5-6,9-14,19,28H,7-8,15H2,1-4H3,(H,29,31,34) BUXPYOUBOFZWIB-UHFFFAOYSA-N 212291 US9290507, I-11 Serine/threonine-protein kinase B-raf Homo sapiens 6 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212291&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464532 329588155 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373842 Cc1ccc(cc1-n1cc(nn1)-c1cncc(NC(C)(C)C)c1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C26H31N7O2/c1-16-8-9-17(24(34)28-23-12-22(35-31-23)25(2,3)4)11-21(16)33-15-20(30-32-33)18-10-19(14-27-13-18)29-26(5,6)7/h8-15,29H,1-7H3,(H,28,31,34) ABLVSEGBGKYZMT-UHFFFAOYSA-N 212292 US9290507, I-12 Serine/threonine-protein kinase B-raf Homo sapiens 18 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212292&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464533 329588156 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373843 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCOCC1)C(=O)Nc1cc(n[nH]1)C(C)(C)C InChI=1S/C26H30N8O2/c1-17-5-6-18(25(35)28-24-13-23(30-31-24)26(2,3)4)12-22(17)34-16-21(29-32-34)19-11-20(15-27-14-19)33-7-9-36-10-8-33/h5-6,11-16H,7-10H2,1-4H3,(H2,28,30,31,35) VXQIFGOGSQNXMC-UHFFFAOYSA-N 212293 US9290507, I-13 Serine/threonine-protein kinase B-raf Homo sapiens 12 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212293&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 124081651 329588157 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373844 CC(C)Nc1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C25H29N7O2/c1-15(2)27-19-9-18(12-26-13-19)20-14-32(31-29-20)21-10-17(8-7-16(21)3)24(33)28-23-11-22(34-30-23)25(4,5)6/h7-15,27H,1-6H3,(H,28,30,33) AUXAQWRWLDBOGS-UHFFFAOYSA-N 212294 US9290507, I-14 Serine/threonine-protein kinase B-raf Homo sapiens 17 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212294&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464591 329588158 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373845 CC1CN(CCN1C)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C28H34N8O2/c1-18-7-8-20(27(37)30-26-13-25(38-32-26)28(3,4)5)12-24(18)36-17-23(31-33-36)21-11-22(15-29-14-21)35-10-9-34(6)19(2)16-35/h7-8,11-15,17,19H,9-10,16H2,1-6H3,(H,30,32,37) CIIKPCOMKCMZLI-UHFFFAOYSA-N 212295 US9290507, I-15 Serine/threonine-protein kinase B-raf Homo sapiens 21 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212295&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464592 329588159 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373846 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCN(CCN2CCOCC2)CC1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C32H41N9O3/c1-23-5-6-24(31(42)34-30-19-29(44-36-30)32(2,3)4)18-28(23)41-22-27(35-37-41)25-17-26(21-33-20-25)40-11-9-38(10-12-40)7-8-39-13-15-43-16-14-39/h5-6,17-22H,7-16H2,1-4H3,(H,34,36,42) XPSNEVISIXTWGW-UHFFFAOYSA-N 212296 US9290507, I-16 Serine/threonine-protein kinase B-raf Homo sapiens 14 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212296&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464593 329588160 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373847 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCCOCC1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C27H31N7O3/c1-18-6-7-19(26(35)29-25-14-24(37-31-25)27(2,3)4)13-23(18)34-17-22(30-32-34)20-12-21(16-28-15-20)33-8-5-10-36-11-9-33/h6-7,12-17H,5,8-11H2,1-4H3,(H,29,31,35) IVDIDLFADZPGMP-UHFFFAOYSA-N 212297 US9290507, I-17 Serine/threonine-protein kinase B-raf Homo sapiens 16 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212297&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464594 329588161 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373848 CN(C)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C24H27N7O2/c1-15-7-8-16(23(32)26-22-11-21(33-28-22)24(2,3)4)10-20(15)31-14-19(27-29-31)17-9-18(30(5)6)13-25-12-17/h7-14H,1-6H3,(H,26,28,32) XOILHXCEKRELFR-UHFFFAOYSA-N 212298 US9290507, I-18 Serine/threonine-protein kinase B-raf Homo sapiens 13 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212298&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464595 329588162 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373849 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCC1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C25H27N7O2/c1-16-6-7-17(24(33)27-23-12-22(34-29-23)25(2,3)4)11-21(16)32-15-20(28-30-32)18-10-19(14-26-13-18)31-8-5-9-31/h6-7,10-15H,5,8-9H2,1-4H3,(H,27,29,33) IGTRFLRHDXVJBJ-UHFFFAOYSA-N 212299 US9290507, I-19 Serine/threonine-protein kinase B-raf Homo sapiens 11 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212299&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89707253 329588163 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373850 COCC(C)Nc1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C26H31N7O3/c1-16-7-8-18(25(34)29-24-11-23(36-31-24)26(3,4)5)10-22(16)33-14-21(30-32-33)19-9-20(13-27-12-19)28-17(2)15-35-6/h7-14,17,28H,15H2,1-6H3,(H,29,31,34) BXNJBCSTYAWZBF-UHFFFAOYSA-N 212300 US9290507, I-20 Serine/threonine-protein kinase B-raf Homo sapiens 31 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212300&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464654 329588164 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373851 Cc1ccc(cc1-n1cc(nn1)-c1cncc(NCC(F)(F)F)c1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C24H24F3N7O2/c1-14-5-6-15(22(35)30-21-9-20(36-32-21)23(2,3)4)8-19(14)34-12-18(31-33-34)16-7-17(11-28-10-16)29-13-24(25,26)27/h5-12,29H,13H2,1-4H3,(H,30,32,35) HAOABJDDIWARPY-UHFFFAOYSA-N 212301 US9290507, I-21 Serine/threonine-protein kinase B-raf Homo sapiens 50 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212301&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464655 329588165 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373852 Cc1ccc(cc1-n1cc(nn1)-c1cncc(NCCF)c1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C24H26FN7O2/c1-15-5-6-16(23(33)28-22-11-21(34-30-22)24(2,3)4)10-20(15)32-14-19(29-31-32)17-9-18(13-26-12-17)27-8-7-25/h5-6,9-14,27H,7-8H2,1-4H3,(H,28,30,33) YMHNMXSRGYGEHJ-UHFFFAOYSA-N 212302 US9290507, I-22 Serine/threonine-protein kinase B-raf Homo sapiens 16 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212302&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464656 329588166 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373853 C[C@H]1CN(C[C@@H](C)O1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C28H33N7O3/c1-17-7-8-20(27(36)30-26-11-25(38-32-26)28(4,5)6)10-24(17)35-16-23(31-33-35)21-9-22(13-29-12-21)34-14-18(2)37-19(3)15-34/h7-13,16,18-19H,14-15H2,1-6H3,(H,30,32,36)/t18-,19+ WCIUBVLNCFVFEX-KDURUIRLSA-N 212303 US9290507, I-23 Serine/threonine-protein kinase B-raf Homo sapiens 26 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212303&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464657 329588167 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373854 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCOCC1)C(=O)Nc1cc(nn1C)C(C)(C)C InChI=1S/C27H32N8O2/c1-18-6-7-19(26(36)29-25-14-24(27(2,3)4)31-33(25)5)13-23(18)35-17-22(30-32-35)20-12-21(16-28-15-20)34-8-10-37-11-9-34/h6-7,12-17H,8-11H2,1-5H3,(H,29,36) MNSOSCSEFSJDPQ-UHFFFAOYSA-N 212304 US9290507, I-24 Serine/threonine-protein kinase B-raf Homo sapiens 19 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212304&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464658 329588168 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373855 CN(CC1CCCO1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C28H33N7O3/c1-18-8-9-19(27(36)30-26-13-25(38-32-26)28(2,3)4)12-24(18)35-17-23(31-33-35)20-11-21(15-29-14-20)34(5)16-22-7-6-10-37-22/h8-9,11-15,17,22H,6-7,10,16H2,1-5H3,(H,30,32,36) DDZUMOARQYZLPR-UHFFFAOYSA-N 212305 US9290507, I-25 Serine/threonine-protein kinase B-raf Homo sapiens 45 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212305&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464720 329588169 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373856 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCN(CC1)C1CC1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C29H34N8O2/c1-19-5-6-20(28(38)31-27-15-26(39-33-27)29(2,3)4)14-25(19)37-18-24(32-34-37)21-13-23(17-30-16-21)36-11-9-35(10-12-36)22-7-8-22/h5-6,13-18,22H,7-12H2,1-4H3,(H,31,33,38) FYCUDYUOHYNHTM-UHFFFAOYSA-N 212306 US9290507, I-26 Serine/threonine-protein kinase B-raf Homo sapiens 28 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212306&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464721 329588170 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373857 CCCCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C30H38N8O2/c1-6-7-10-36-11-13-37(14-12-36)24-15-23(18-31-19-24)25-20-38(35-33-25)26-16-22(9-8-21(26)2)29(39)32-28-17-27(40-34-28)30(3,4)5/h8-9,15-20H,6-7,10-14H2,1-5H3,(H,32,34,39) HYIHCBSJLIQUEP-UHFFFAOYSA-N 212307 US9290507, I-27 Serine/threonine-protein kinase B-raf Homo sapiens 15 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212307&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464722 329588171 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373858 Cc1ccc(cc1-n1cc(nn1)-c1cncc(NC2CC2)c1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C25H27N7O2/c1-15-5-6-16(24(33)28-23-11-22(34-30-23)25(2,3)4)10-21(15)32-14-20(29-31-32)17-9-19(13-26-12-17)27-18-7-8-18/h5-6,9-14,18,27H,7-8H2,1-4H3,(H,28,30,33) RIPJDSDGSQEXSS-UHFFFAOYSA-N 212308 US9290507, I-28 Serine/threonine-protein kinase B-raf Homo sapiens 10 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212308&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464723 329588172 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373859 CN(C1CCOCC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C28H33N7O3/c1-18-6-7-19(27(36)30-26-14-25(38-32-26)28(2,3)4)13-24(18)35-17-23(31-33-35)20-12-22(16-29-15-20)34(5)21-8-10-37-11-9-21/h6-7,12-17,21H,8-11H2,1-5H3,(H,30,32,36) YNXDKQSIIHWJFI-UHFFFAOYSA-N 212309 US9290507, I-29 Serine/threonine-protein kinase B-raf Homo sapiens 7 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212309&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464724 329588173 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373860 CNc1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C23H25N7O2/c1-14-6-7-15(22(31)26-21-10-20(32-28-21)23(2,3)4)9-19(14)30-13-18(27-29-30)16-8-17(24-5)12-25-11-16/h6-13,24H,1-5H3,(H,26,28,31) JDGIBDCXYKDOFT-UHFFFAOYSA-N 212310 US9290507, I-30 Serine/threonine-protein kinase B-raf Homo sapiens 14 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212310&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89708472 329588174 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373861 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCN(CC(F)(F)F)CC1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C28H31F3N8O2/c1-18-5-6-19(26(40)33-25-13-24(41-35-25)27(2,3)4)12-23(18)39-16-22(34-36-39)20-11-21(15-32-14-20)38-9-7-37(8-10-38)17-28(29,30)31/h5-6,11-16H,7-10,17H2,1-4H3,(H,33,35,40) BWTXZFVMPJLBNL-UHFFFAOYSA-N 212311 US9290507, I-31 Serine/threonine-protein kinase B-raf Homo sapiens 98 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212311&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464781 329588175 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373862 CC1CN(CC(C)N1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C28H34N8O2/c1-17-7-8-20(27(37)31-26-11-25(38-33-26)28(4,5)6)10-24(17)36-16-23(32-34-36)21-9-22(13-29-12-21)35-14-18(2)30-19(3)15-35/h7-13,16,18-19,30H,14-15H2,1-6H3,(H,31,33,37) JDCCLCGGXFHGLK-UHFFFAOYSA-N 212312 US9290507, I-32 Serine/threonine-protein kinase B-raf Homo sapiens 9 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212312&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700803 329588176 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373863 CCN1CCN(CC1C)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C29H36N8O2/c1-7-35-10-11-36(17-20(35)3)23-12-22(15-30-16-23)24-18-37(34-32-24)25-13-21(9-8-19(25)2)28(38)31-27-14-26(39-33-27)29(4,5)6/h8-9,12-16,18,20H,7,10-11,17H2,1-6H3,(H,31,33,38) LUBLPTWJMOFOCK-UHFFFAOYSA-N 212313 US9290507, I-33 Serine/threonine-protein kinase B-raf Homo sapiens 11 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212313&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464782 329588177 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373864 Cc1ccc(cc1-n1cc(nn1)-c1cncc(NCC2CCCO2)c1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C27H31N7O3/c1-17-7-8-18(26(35)30-25-12-24(37-32-25)27(2,3)4)11-23(17)34-16-22(31-33-34)19-10-20(14-28-13-19)29-15-21-6-5-9-36-21/h7-8,10-14,16,21,29H,5-6,9,15H2,1-4H3,(H,30,32,35) FICYJMRTFDQEBP-UHFFFAOYSA-N 212314 US9290507, I-34 Serine/threonine-protein kinase B-raf Homo sapiens 9 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212314&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700787 329588178 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373865 CC(C)N(C)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C26H31N7O2/c1-16(2)32(7)20-10-19(13-27-14-20)21-15-33(31-29-21)22-11-18(9-8-17(22)3)25(34)28-24-12-23(35-30-24)26(4,5)6/h8-16H,1-7H3,(H,28,30,34) WZEICYCQAMYIMF-UHFFFAOYSA-N 212315 US9290507, I-35 Serine/threonine-protein kinase B-raf Homo sapiens 45 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212315&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464783 329588179 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373866 COCCNc1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C25H29N7O3/c1-16-6-7-17(24(33)28-23-12-22(35-30-23)25(2,3)4)11-21(16)32-15-20(29-31-32)18-10-19(14-26-13-18)27-8-9-34-5/h6-7,10-15,27H,8-9H2,1-5H3,(H,28,30,33) UQMMDSQNHSNVLU-UHFFFAOYSA-N 212316 US9290507, I-36 Serine/threonine-protein kinase B-raf Homo sapiens 16 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212316&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464784 329588180 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373867 CC(C)N1CCN(CC1C)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C30H38N8O2/c1-19(2)37-11-10-36(17-21(37)4)24-12-23(15-31-16-24)25-18-38(35-33-25)26-13-22(9-8-20(26)3)29(39)32-28-14-27(40-34-28)30(5,6)7/h8-9,12-16,18-19,21H,10-11,17H2,1-7H3,(H,32,34,39) KSJFFOOOFYATCA-UHFFFAOYSA-N 212317 US9290507, I-37 Serine/threonine-protein kinase B-raf Homo sapiens 20 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212317&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464785 329588181 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373868 Cc1ccc(cc1-n1cc(nn1)-c1cncc(NC2CCOCC2)c1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C27H31N7O3/c1-17-5-6-18(26(35)30-25-13-24(37-32-25)27(2,3)4)12-23(17)34-16-22(31-33-34)19-11-21(15-28-14-19)29-20-7-9-36-10-8-20/h5-6,11-16,20,29H,7-10H2,1-4H3,(H,30,32,35) OOQARFRXSQBYFP-UHFFFAOYSA-N 212318 US9290507, I-38 Serine/threonine-protein kinase B-raf Homo sapiens 10 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212318&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700623 329588182 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373869 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCCC1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C26H29N7O2/c1-17-7-8-18(25(34)28-24-13-23(35-30-24)26(2,3)4)12-22(17)33-16-21(29-31-33)19-11-20(15-27-14-19)32-9-5-6-10-32/h7-8,11-16H,5-6,9-10H2,1-4H3,(H,28,30,34) DDYHLPUXNXOYOO-UHFFFAOYSA-N 212319 US9290507, I-39 Serine/threonine-protein kinase B-raf Homo sapiens 41 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212319&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464843 329588183 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373870 COCCCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C30H38N8O3/c1-21-7-8-22(29(39)32-28-17-27(41-34-28)30(2,3)4)16-26(21)38-20-25(33-35-38)23-15-24(19-31-18-23)37-12-10-36(11-13-37)9-6-14-40-5/h7-8,15-20H,6,9-14H2,1-5H3,(H,32,34,39) KVRODINJDZOXTQ-UHFFFAOYSA-N 212320 US9290507, I-40 Serine/threonine-protein kinase B-raf Homo sapiens 19 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212320&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700902 329588184 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373871 CCCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C29H36N8O2/c1-6-9-35-10-12-36(13-11-35)23-14-22(17-30-18-23)24-19-37(34-32-24)25-15-21(8-7-20(25)2)28(38)31-27-16-26(39-33-27)29(3,4)5/h7-8,14-19H,6,9-13H2,1-5H3,(H,31,33,38) GKGCPSYYBZFQPM-UHFFFAOYSA-N 212321 US9290507, I-41 Serine/threonine-protein kinase B-raf Homo sapiens 8 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212321&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700905 329588185 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373872 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCCCC1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C27H31N7O2/c1-18-8-9-19(26(35)29-25-14-24(36-31-25)27(2,3)4)13-23(18)34-17-22(30-32-34)20-12-21(16-28-15-20)33-10-6-5-7-11-33/h8-9,12-17H,5-7,10-11H2,1-4H3,(H,29,31,35) GMKOONDJNPWBEC-UHFFFAOYSA-N 212322 US9290507, I-42 Serine/threonine-protein kinase B-raf Homo sapiens 61 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212322&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464844 329588186 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373873 Cc1ccc(cc1-n1cc(nn1)-c1cncc(NC2CCCC2)c1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C27H31N7O2/c1-17-9-10-18(26(35)30-25-13-24(36-32-25)27(2,3)4)12-23(17)34-16-22(31-33-34)19-11-21(15-28-14-19)29-20-7-5-6-8-20/h9-16,20,29H,5-8H2,1-4H3,(H,30,32,35) KRQURAMGEOQYRM-UHFFFAOYSA-N 212323 US9290507, I-43 Serine/threonine-protein kinase B-raf Homo sapiens 38 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212323&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464845 329588187 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373874 CC(C)N1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C29H36N8O2/c1-19(2)35-9-11-36(12-10-35)23-13-22(16-30-17-23)24-18-37(34-32-24)25-14-21(8-7-20(25)3)28(38)31-27-15-26(39-33-27)29(4,5)6/h7-8,13-19H,9-12H2,1-6H3,(H,31,33,38) KYEDJZMFPQINTR-UHFFFAOYSA-N 212324 US9290507, I-44 Serine/threonine-protein kinase B-raf Homo sapiens 11 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212324&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464846 329588188 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373875 COCCN1C(C)CN(CC1C)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C31H40N8O3/c1-20-8-9-23(30(40)33-29-14-28(42-35-29)31(4,5)6)13-27(20)39-19-26(34-36-39)24-12-25(16-32-15-24)37-17-21(2)38(10-11-41-7)22(3)18-37/h8-9,12-16,19,21-22H,10-11,17-18H2,1-7H3,(H,33,35,40) PAWYRQYRXSVHAV-UHFFFAOYSA-N 212325 US9290507, I-45 Serine/threonine-protein kinase B-raf Homo sapiens 29 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212325&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464847 329588189 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373876 CN(C)CCNc1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C26H32N8O2/c1-17-7-8-18(25(35)29-24-13-23(36-31-24)26(2,3)4)12-22(17)34-16-21(30-32-34)19-11-20(15-27-14-19)28-9-10-33(5)6/h7-8,11-16,28H,9-10H2,1-6H3,(H,29,31,35) KLXHGLQHMMAYQB-UHFFFAOYSA-N 212326 US9290507, I-46 Serine/threonine-protein kinase B-raf Homo sapiens 7 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212326&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700653 329588190 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373877 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCOCC1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C26H29N7O3/c1-17-5-6-18(25(34)28-24-13-23(36-30-24)26(2,3)4)12-22(17)33-16-21(29-31-33)19-11-20(15-27-14-19)32-7-9-35-10-8-32/h5-6,11-16H,7-10H2,1-4H3,(H,28,30,34) RQEQPPMWXBAZEE-UHFFFAOYSA-N 212327 US9290507, I-47 Serine/threonine-protein kinase B-raf Homo sapiens 10 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212327&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464903 329588191 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373878 CCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C28H34N8O2/c1-6-34-9-11-35(12-10-34)22-13-21(16-29-17-22)23-18-36(33-31-23)24-14-20(8-7-19(24)2)27(37)30-26-15-25(38-32-26)28(3,4)5/h7-8,13-18H,6,9-12H2,1-5H3,(H,30,32,37) NDBSPWLIHMFFTA-UHFFFAOYSA-N 212328 US9290507, I-48 Serine/threonine-protein kinase B-raf Homo sapiens 6 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212328&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464904 329588192 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373879 CCOCCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C30H38N8O3/c1-6-40-14-13-36-9-11-37(12-10-36)24-15-23(18-31-19-24)25-20-38(35-33-25)26-16-22(8-7-21(26)2)29(39)32-28-17-27(41-34-28)30(3,4)5/h7-8,15-20H,6,9-14H2,1-5H3,(H,32,34,39) ASEFUWVIUFOOQB-UHFFFAOYSA-N 212329 US9290507, I-49 Serine/threonine-protein kinase B-raf Homo sapiens 29 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212329&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700828 329588193 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373880 CC(C)CN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C30H38N8O2/c1-20(2)18-36-9-11-37(12-10-36)24-13-23(16-31-17-24)25-19-38(35-33-25)26-14-22(8-7-21(26)3)29(39)32-28-15-27(40-34-28)30(4,5)6/h7-8,13-17,19-20H,9-12,18H2,1-6H3,(H,32,34,39) OVDRSVMKDGTAKN-UHFFFAOYSA-N 212330 US9290507, I-50 Serine/threonine-protein kinase B-raf Homo sapiens 13 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212330&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464905 329588194 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373881 CN(C)C1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C29H36N8O2/c1-19-7-8-20(28(38)31-27-15-26(39-33-27)29(2,3)4)14-25(19)37-18-24(32-34-37)21-13-23(17-30-16-21)36-11-9-22(10-12-36)35(5)6/h7-8,13-18,22H,9-12H2,1-6H3,(H,31,33,38) ODMUHWZUJSAIOD-UHFFFAOYSA-N 212331 US9290507, I-51 Serine/threonine-protein kinase B-raf Homo sapiens 12 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212331&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700736 329588195 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373882 CC(C)N1CCCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C30H38N8O2/c1-20(2)36-10-7-11-37(13-12-36)24-14-23(17-31-18-24)25-19-38(35-33-25)26-15-22(9-8-21(26)3)29(39)32-28-16-27(40-34-28)30(4,5)6/h8-9,14-20H,7,10-13H2,1-6H3,(H,32,34,39) BUBCMPMDZNNDIQ-UHFFFAOYSA-N 212332 US9290507, I-52 Serine/threonine-protein kinase B-raf Homo sapiens 18 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212332&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464906 329588196 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373883 COCCN(C)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C26H31N7O3/c1-17-7-8-18(25(34)28-24-13-23(36-30-24)26(2,3)4)12-22(17)33-16-21(29-31-33)19-11-20(15-27-14-19)32(5)9-10-35-6/h7-8,11-16H,9-10H2,1-6H3,(H,28,30,34) LGKOYZKZFPXYFT-UHFFFAOYSA-N 212333 US9290507, I-53 Serine/threonine-protein kinase B-raf Homo sapiens 11 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212333&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700593 329588197 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373884 Cc1ccc(cc1-n1cc(nn1)-c1cncc(NCC(F)F)c1)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C24H25F2N7O2/c1-14-5-6-15(23(34)29-22-9-20(35-31-22)24(2,3)4)8-19(14)33-13-18(30-32-33)16-7-17(11-27-10-16)28-12-21(25)26/h5-11,13,21,28H,12H2,1-4H3,(H,29,31,34) WNYONRPCXMBITO-UHFFFAOYSA-N 212334 US9290507, I-54 Serine/threonine-protein kinase B-raf Homo sapiens 51 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212334&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464907 329588198 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373885 CN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(nn1C)C(C)(C)C InChI=1S/C28H35N9O/c1-19-7-8-20(27(38)30-26-15-25(28(2,3)4)32-35(26)6)14-24(19)37-18-23(31-33-37)21-13-22(17-29-16-21)36-11-9-34(5)10-12-36/h7-8,13-18H,9-12H2,1-6H3,(H,30,38) HBXHRLBONWLAHK-UHFFFAOYSA-N 212335 US9290507, I-55 Serine/threonine-protein kinase B-raf Homo sapiens 16 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212335&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464965 329588199 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373886 CCN(C)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C25H29N7O2/c1-7-31(6)19-10-18(13-26-14-19)20-15-32(30-28-20)21-11-17(9-8-16(21)2)24(33)27-23-12-22(34-29-23)25(3,4)5/h8-15H,7H2,1-6H3,(H,27,29,33) NSOVXBNKVVKMCX-UHFFFAOYSA-N 212336 US9290507, I-56 Serine/threonine-protein kinase B-raf Homo sapiens 18 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212336&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89707258 329588200 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373887 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCC1)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C24H20F3N7O/c1-15-3-4-16(23(35)30-22-11-18(5-6-29-22)24(25,26)27)10-21(15)34-14-20(31-32-34)17-9-19(13-28-12-17)33-7-2-8-33/h3-6,9-14H,2,7-8H2,1H3,(H,29,30,35) WQNAOIHLCGWVOM-UHFFFAOYSA-N 212337 US9290507, I-57 Serine/threonine-protein kinase B-raf Homo sapiens 16 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212337&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464966 329588201 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373888 Cc1ccc(cc1-n1cc(nn1)-c1cncc(NCC2CCCO2)c1)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C26H24F3N7O2/c1-16-4-5-17(25(37)33-24-11-19(6-7-31-24)26(27,28)29)10-23(16)36-15-22(34-35-36)18-9-20(13-30-12-18)32-14-21-3-2-8-38-21/h4-7,9-13,15,21,32H,2-3,8,14H2,1H3,(H,31,33,37) CSRDMUXGZCAREQ-UHFFFAOYSA-N 212338 US9290507, I-58 Serine/threonine-protein kinase B-raf Homo sapiens 11 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212338&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700541 329588202 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373889 CN(CC1CCCO1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C27H26F3N7O2/c1-17-5-6-18(26(38)33-25-12-20(7-8-32-25)27(28,29)30)11-24(17)37-16-23(34-35-37)19-10-21(14-31-13-19)36(2)15-22-4-3-9-39-22/h5-8,10-14,16,22H,3-4,9,15H2,1-2H3,(H,32,33,38) FTWJFTLHYIMPDI-UHFFFAOYSA-N 212339 US9290507, I-59 Serine/threonine-protein kinase B-raf Homo sapiens 44 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212339&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464968 329588203 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373890 CN(C)C1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C28H29F3N8O/c1-18-4-5-19(27(40)34-26-14-21(6-9-33-26)28(29,30)31)13-25(18)39-17-24(35-36-39)20-12-23(16-32-15-20)38-10-7-22(8-11-38)37(2)3/h4-6,9,12-17,22H,7-8,10-11H2,1-3H3,(H,33,34,40) LXCUQMOWNGHZSS-UHFFFAOYSA-N 212340 US9290507, I-60 Serine/threonine-protein kinase B-raf Homo sapiens 8 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212340&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464969 329588204 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373891 COCCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C28H29F3N8O2/c1-19-3-4-20(27(40)34-26-15-22(5-6-33-26)28(29,30)31)14-25(19)39-18-24(35-36-39)21-13-23(17-32-16-21)38-9-7-37(8-10-38)11-12-41-2/h3-6,13-18H,7-12H2,1-2H3,(H,33,34,40) BOHVJZNCVSVWCV-UHFFFAOYSA-N 212341 US9290507, I-61 Serine/threonine-protein kinase B-raf Homo sapiens 11 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212341&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700898 329588205 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373892 CN(C)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C23H20F3N7O/c1-14-4-5-15(22(34)29-21-10-17(6-7-28-21)23(24,25)26)9-20(14)33-13-19(30-31-33)16-8-18(32(2)3)12-27-11-16/h4-13H,1-3H3,(H,28,29,34) XPHVDNRZZLTRDU-UHFFFAOYSA-N 212342 US9290507, I-62 Serine/threonine-protein kinase B-raf Homo sapiens 24 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212342&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465027 329588206 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373893 CN1CCC(C1)Nc1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C26H25F3N8O/c1-16-3-4-17(25(38)33-24-11-19(5-7-31-24)26(27,28)29)10-23(16)37-15-22(34-35-37)18-9-21(13-30-12-18)32-20-6-8-36(2)14-20/h3-5,7,9-13,15,20,32H,6,8,14H2,1-2H3,(H,31,33,38) OBEXXTVYTXIYKD-UHFFFAOYSA-N 212343 US9290507, I-63 Serine/threonine-protein kinase B-raf Homo sapiens 6 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212343&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465028 329588207 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373894 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCCCC1)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C26H24F3N7O/c1-17-5-6-18(25(37)32-24-13-20(7-8-31-24)26(27,28)29)12-23(17)36-16-22(33-34-36)19-11-21(15-30-14-19)35-9-3-2-4-10-35/h5-8,11-16H,2-4,9-10H2,1H3,(H,31,32,37) VTIFHHGVTURRAG-UHFFFAOYSA-N 212344 US9290507, I-64 Serine/threonine-protein kinase B-raf Homo sapiens 69 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212344&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465029 329588208 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373895 CN(CCN1CCCC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C28H29F3N8O/c1-19-5-6-20(27(40)34-26-15-22(7-8-33-26)28(29,30)31)14-25(19)39-18-24(35-36-39)21-13-23(17-32-16-21)37(2)11-12-38-9-3-4-10-38/h5-8,13-18H,3-4,9-12H2,1-2H3,(H,33,34,40) JVHSCCOVJXRVFZ-UHFFFAOYSA-N 212345 US9290507, I-65 Serine/threonine-protein kinase B-raf Homo sapiens 9 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212345&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700602 329588209 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373896 Cc1ccc(cc1-n1cc(nn1)-c1cncc(NC2CC2)c1)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C24H20F3N7O/c1-14-2-3-15(23(35)31-22-10-17(6-7-29-22)24(25,26)27)9-21(14)34-13-20(32-33-34)16-8-19(12-28-11-16)30-18-4-5-18/h2-3,6-13,18,30H,4-5H2,1H3,(H,29,31,35) WAKHKROVYRMZEP-UHFFFAOYSA-N 212346 US9290507, I-66 Serine/threonine-protein kinase B-raf Homo sapiens 44 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212346&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465030 329588210 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373897 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCCOCC1)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C26H24F3N7O2/c1-17-3-4-18(25(37)32-24-13-20(5-6-31-24)26(27,28)29)12-23(17)36-16-22(33-34-36)19-11-21(15-30-14-19)35-7-2-9-38-10-8-35/h3-6,11-16H,2,7-10H2,1H3,(H,31,32,37) ZYZBVGVNBIGPIB-UHFFFAOYSA-N 212347 US9290507, I-67 Serine/threonine-protein kinase B-raf Homo sapiens 24 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212347&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700968 329588211 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373898 CN(C1CCOC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C26H24F3N7O2/c1-16-3-4-17(25(37)32-24-11-19(5-7-31-24)26(27,28)29)10-23(16)36-14-22(33-34-36)18-9-21(13-30-12-18)35(2)20-6-8-38-15-20/h3-5,7,9-14,20H,6,8,15H2,1-2H3,(H,31,32,37) QZLYEEJKBKZBIR-UHFFFAOYSA-N 212348 US9290507, I-68 Serine/threonine-protein kinase B-raf Homo sapiens 7 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212348&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465031 329588212 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373899 CN(C1CCOCC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C27H26F3N7O2/c1-17-3-4-18(26(38)33-25-13-20(5-8-32-25)27(28,29)30)12-24(17)37-16-23(34-35-37)19-11-22(15-31-14-19)36(2)21-6-9-39-10-7-21/h3-5,8,11-16,21H,6-7,9-10H2,1-2H3,(H,32,33,38) DMZPEEISRJPQKJ-UHFFFAOYSA-N 212349 US9290507, I-69 Serine/threonine-protein kinase B-raf Homo sapiens 30 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212349&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700865 329588213 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373900 Cc1ccc(cc1-n1cc(nn1)-c1cncc(NC2CCOC2)c1)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C25H22F3N7O2/c1-15-2-3-16(24(36)32-23-10-18(4-6-30-23)25(26,27)28)9-22(15)35-13-21(33-34-35)17-8-20(12-29-11-17)31-19-5-7-37-14-19/h2-4,6,8-13,19,31H,5,7,14H2,1H3,(H,30,32,36) MUZCYBOFIJXZNV-UHFFFAOYSA-N 212350 US9290507, I-70 Serine/threonine-protein kinase B-raf Homo sapiens 11 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212350&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700985 329588214 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373901 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1C[C@@H]2C[C@H]1CN2)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C26H23F3N8O/c1-15-2-3-16(25(38)33-24-8-18(4-5-31-24)26(27,28)29)7-23(15)37-14-22(34-35-37)17-6-20(11-30-10-17)36-13-19-9-21(36)12-32-19/h2-8,10-11,14,19,21,32H,9,12-13H2,1H3,(H,31,33,38)/t19-,21-/m0/s1 PFPOPNWNTZLCJA-FPOVZHCZSA-N 212351 US9290507, I-71 Serine/threonine-protein kinase B-raf Homo sapiens 4 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212351&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89708460 329588215 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373902 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCOCC1)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C25H22F3N7O2/c1-16-2-3-17(24(36)31-23-12-19(4-5-30-23)25(26,27)28)11-22(16)35-15-21(32-33-35)18-10-20(14-29-13-18)34-6-8-37-9-7-34/h2-5,10-15H,6-9H2,1H3,(H,30,31,36) SXYPDORQXYTNSX-UHFFFAOYSA-N 212352 US9290507, I-72 Serine/threonine-protein kinase B-raf Homo sapiens 12 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212352&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700831 329588216 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373903 COCCN(C)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C25H24F3N7O2/c1-16-4-5-17(24(36)31-23-12-19(6-7-30-23)25(26,27)28)11-22(16)35-15-21(32-33-35)18-10-20(14-29-13-18)34(2)8-9-37-3/h4-7,10-15H,8-9H2,1-3H3,(H,30,31,36) IDCOKADKSRJDFI-UHFFFAOYSA-N 212353 US9290507, I-73 Serine/threonine-protein kinase B-raf Homo sapiens 34 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212353&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465091 329588217 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373904 CN(C1CCN(C)CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C28H29F3N8O/c1-18-4-5-19(27(40)34-26-14-21(6-9-33-26)28(29,30)31)13-25(18)39-17-24(35-36-39)20-12-23(16-32-15-20)38(3)22-7-10-37(2)11-8-22/h4-6,9,12-17,22H,7-8,10-11H2,1-3H3,(H,33,34,40) VKBPECGNYQKXTG-UHFFFAOYSA-N 212354 US9290507, I-74 Serine/threonine-protein kinase B-raf Homo sapiens 12 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212354&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700726 329588218 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373905 CN(C)C1CCN(C1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C27H27F3N8O/c1-17-4-5-18(26(39)33-25-12-20(6-8-32-25)27(28,29)30)11-24(17)38-16-23(34-35-38)19-10-22(14-31-13-19)37-9-7-21(15-37)36(2)3/h4-6,8,10-14,16,21H,7,9,15H2,1-3H3,(H,32,33,39) HDMBORCMWKIQAY-UHFFFAOYSA-N 212355 US9290507, I-75 Serine/threonine-protein kinase B-raf Homo sapiens 7 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212355&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465092 329588219 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373906 CN1CCC(CC1)Nc1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C27H27F3N8O/c1-17-3-4-18(26(39)34-25-13-20(5-8-32-25)27(28,29)30)12-24(17)38-16-23(35-36-38)19-11-22(15-31-14-19)33-21-6-9-37(2)10-7-21/h3-5,8,11-16,21,33H,6-7,9-10H2,1-2H3,(H,32,34,39) IPYCDBMGZHDWKG-UHFFFAOYSA-N 212356 US9290507, I-76 Serine/threonine-protein kinase B-raf Homo sapiens 21 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212356&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465093 329588220 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373907 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCNCC1)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C25H23F3N8O/c1-16-2-3-17(24(37)32-23-12-19(4-5-31-23)25(26,27)28)11-22(16)36-15-21(33-34-36)18-10-20(14-30-13-18)35-8-6-29-7-9-35/h2-5,10-15,29H,6-9H2,1H3,(H,31,32,37) IHNQJLJQPQXXKL-UHFFFAOYSA-N 212357 US9290507, I-77 Serine/threonine-protein kinase B-raf Homo sapiens 5 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212357&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465094 329588221 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373908 CN(C1CCN(C)C1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C27H27F3N8O/c1-17-4-5-18(26(39)33-25-12-20(6-8-32-25)27(28,29)30)11-24(17)38-16-23(34-35-38)19-10-22(14-31-13-19)37(3)21-7-9-36(2)15-21/h4-6,8,10-14,16,21H,7,9,15H2,1-3H3,(H,32,33,39) XPNSQZZBGJJWJG-UHFFFAOYSA-N 212358 US9290507, I-78 Serine/threonine-protein kinase B-raf Homo sapiens 4 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212358&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700907 329588222 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373909 CN(C)[C@H]1CCN(C1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C27H27F3N8O/c1-17-4-5-18(26(39)33-25-12-20(6-8-32-25)27(28,29)30)11-24(17)38-16-23(34-35-38)19-10-22(14-31-13-19)37-9-7-21(15-37)36(2)3/h4-6,8,10-14,16,21H,7,9,15H2,1-3H3,(H,32,33,39)/t21-/m0/s1 HDMBORCMWKIQAY-NRFANRHFSA-N 212359 US9290507, I-79 Serine/threonine-protein kinase B-raf Homo sapiens 9 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212359&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465166 329588223 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373910 CN(C)[C@@H]1CCN(C1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C27H27F3N8O/c1-17-4-5-18(26(39)33-25-12-20(6-8-32-25)27(28,29)30)11-24(17)38-16-23(34-35-38)19-10-22(14-31-13-19)37-9-7-21(15-37)36(2)3/h4-6,8,10-14,16,21H,7,9,15H2,1-3H3,(H,32,33,39)/t21-/m1/s1 HDMBORCMWKIQAY-OAQYLSRUSA-N 212360 US9290507, I-80 Serine/threonine-protein kinase B-raf Homo sapiens 15 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212360&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89707259 329588224 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373911 Cc1ccc(cc1-n1cc(nn1)-c1cncc(NC2CCOCC2)c1)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C26H24F3N7O2/c1-16-2-3-17(25(37)33-24-12-19(4-7-31-24)26(27,28)29)11-23(16)36-15-22(34-35-36)18-10-21(14-30-13-18)32-20-5-8-38-9-6-20/h2-4,7,10-15,20,32H,5-6,8-9H2,1H3,(H,31,33,37) IETZOCLJGCDMDS-UHFFFAOYSA-N 212361 US9290507, I-81 Serine/threonine-protein kinase B-raf Homo sapiens 10 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212361&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465167 329588225 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373912 CN1C[C@@H]2C[C@H]1CN2c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C27H25F3N8O/c1-16-3-4-17(26(39)33-25-9-19(5-6-32-25)27(28,29)30)8-24(16)38-15-23(34-35-38)18-7-20(12-31-11-18)37-14-21-10-22(37)13-36(21)2/h3-9,11-12,15,21-22H,10,13-14H2,1-2H3,(H,32,33,39)/t21-,22-/m0/s1 UIVCUNYROJRLBP-VXKWHMMOSA-N 212362 US9290507, I-82 Serine/threonine-protein kinase B-raf Homo sapiens 6 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212362&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89707260 329588226 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373913 CN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C26H25F3N8O/c1-17-3-4-18(25(38)32-24-13-20(5-6-31-24)26(27,28)29)12-23(17)37-16-22(33-34-37)19-11-21(15-30-14-19)36-9-7-35(2)8-10-36/h3-6,11-16H,7-10H2,1-2H3,(H,31,32,38) DPEPZQPTURAHMG-UHFFFAOYSA-N 212363 US9290507, I-83 Serine/threonine-protein kinase B-raf Homo sapiens 7 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212363&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700864 329588227 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373914 Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCCC1)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C25H22F3N7O/c1-16-4-5-17(24(36)31-23-12-19(6-7-30-23)25(26,27)28)11-22(16)35-15-21(32-33-35)18-10-20(14-29-13-18)34-8-2-3-9-34/h4-7,10-15H,2-3,8-9H2,1H3,(H,30,31,36) FDHJQTFPEYOGRE-UHFFFAOYSA-N 212364 US9290507, I-84 Serine/threonine-protein kinase B-raf Homo sapiens 7 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212364&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465169 329588228 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373915 CN(C)CCNc1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C25H25F3N8O/c1-16-4-5-17(24(37)32-23-12-19(6-7-31-23)25(26,27)28)11-22(16)36-15-21(33-34-36)18-10-20(14-29-13-18)30-8-9-35(2)3/h4-7,10-15,30H,8-9H2,1-3H3,(H,31,32,37) HERPQSOQAYRJBG-UHFFFAOYSA-N 212365 US9290507, I-85 Serine/threonine-protein kinase B-raf Homo sapiens 10 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212365&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700714 329588229 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373916 CN(C)CCN(C)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C26H27F3N8O/c1-17-5-6-18(25(38)32-24-13-20(7-8-31-24)26(27,28)29)12-23(17)37-16-22(33-34-37)19-11-21(15-30-14-19)36(4)10-9-35(2)3/h5-8,11-16H,9-10H2,1-4H3,(H,31,32,38) XRTYPUIMWWVPCS-UHFFFAOYSA-N 212366 US9290507, I-86 Serine/threonine-protein kinase B-raf Homo sapiens 10 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212366&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465170 329588230 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373917 CCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C27H27F3N8O/c1-3-36-8-10-37(11-9-36)22-12-20(15-31-16-22)23-17-38(35-34-23)24-13-19(5-4-18(24)2)26(39)33-25-14-21(6-7-32-25)27(28,29)30/h4-7,12-17H,3,8-11H2,1-2H3,(H,32,33,39) JMJFSJZEYMNBOE-UHFFFAOYSA-N 212367 US9290507, I-87 Serine/threonine-protein kinase B-raf Homo sapiens 7 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212367&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465237 329588231 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373918 CC(C)N1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(ccn1)C(F)(F)F InChI=1S/C28H29F3N8O/c1-18(2)37-8-10-38(11-9-37)23-12-21(15-32-16-23)24-17-39(36-35-24)25-13-20(5-4-19(25)3)27(40)34-26-14-22(6-7-33-26)28(29,30)31/h4-7,12-18H,8-11H2,1-3H3,(H,33,34,40) UYPHUQOZPBSELH-UHFFFAOYSA-N 212368 US9290507, I-88 Serine/threonine-protein kinase B-raf Homo sapiens 8 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212368&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89701045 329588232 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373919 CN1CCN(CC1)C1CCN(C1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C31H39N9O2/c1-21-6-7-22(30(41)33-29-16-28(42-35-29)31(2,3)4)15-27(21)40-20-26(34-36-40)23-14-25(18-32-17-23)39-9-8-24(19-39)38-12-10-37(5)11-13-38/h6-7,14-18,20,24H,8-13,19H2,1-5H3,(H,33,35,41) JQXORVQRPOJWJL-UHFFFAOYSA-N 212369 US9290507, I-89 Serine/threonine-protein kinase B-raf Homo sapiens 6 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212369&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465238 329588233 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373920 CN1CCN(CC1)C1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C32H41N9O2/c1-22-6-7-23(31(42)34-30-18-29(43-36-30)32(2,3)4)17-28(22)41-21-27(35-37-41)24-16-26(20-33-19-24)39-10-8-25(9-11-39)40-14-12-38(5)13-15-40/h6-7,16-21,25H,8-15H2,1-5H3,(H,34,36,42) CNKBCOPETZRMDE-UHFFFAOYSA-N 212370 US9290507, I-90 Serine/threonine-protein kinase B-raf Homo sapiens 10 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212370&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465239 329588234 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373921 CN1CCCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C28H34N8O2/c1-19-7-8-20(27(37)30-26-15-25(38-32-26)28(2,3)4)14-24(19)36-18-23(31-33-36)21-13-22(17-29-16-21)35-10-6-9-34(5)11-12-35/h7-8,13-18H,6,9-12H2,1-5H3,(H,30,32,37) BWUZXLRHKZXGGK-UHFFFAOYSA-N 212371 US9290507, I-91 Serine/threonine-protein kinase B-raf Homo sapiens 8 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212371&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465240 329588235 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373922 CC(C)N1CCN(CC1)C1CCN(C1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C33H43N9O2/c1-22(2)39-11-13-40(14-12-39)26-9-10-41(20-26)27-15-25(18-34-19-27)28-21-42(38-36-28)29-16-24(8-7-23(29)3)32(43)35-31-17-30(44-37-31)33(4,5)6/h7-8,15-19,21-22,26H,9-14,20H2,1-6H3,(H,35,37,43) XKWCJKPPLRDKFT-UHFFFAOYSA-N 212372 US9290507, I-92 Serine/threonine-protein kinase B-raf Homo sapiens 8 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212372&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53465241 329588236 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373923 CN1CCN(CC1)C1CN(C1)c1cncc(c1)-c1cn(nn1)-c1cc(ccc1C)C(=O)Nc1cc(on1)C(C)(C)C InChI=1S/C30H37N9O2/c1-20-6-7-21(29(40)32-28-14-27(41-34-28)30(2,3)4)13-26(20)39-19-25(33-35-39)22-12-23(16-31-15-22)38-17-24(18-38)37-10-8-36(5)9-11-37/h6-7,12-16,19,24H,8-11,17-18H2,1-5H3,(H,32,34,40) OAZDGACWKJQCQV-UHFFFAOYSA-N 212373 US9290507, I-93 Serine/threonine-protein kinase B-raf Homo sapiens 8 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212373&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700798 329588237 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373924 Cc1ccc(NC(=O)c2cc(ccn2)C(F)(F)F)cc1-n1cc(nn1)-c1cncc(c1)N1CCOCC1 InChI=1S/C25H22F3N7O2/c1-16-2-3-19(31-24(36)21-11-18(4-5-30-21)25(26,27)28)12-23(16)35-15-22(32-33-35)17-10-20(14-29-13-17)34-6-8-37-9-7-34/h2-5,10-15H,6-9H2,1H3,(H,31,36) OAEBOVXPSWAUAM-UHFFFAOYSA-N 212388 US9290507, II-1 Serine/threonine-protein kinase B-raf Homo sapiens 9 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212388&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464282 329588238 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373925 CC(C)NCc1cc(oc1C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1cc(nn1)-c1cncc(c1)N1CCOCC1 InChI=1S/C31H39N7O3/c1-20(2)33-17-23-14-28(41-29(23)31(4,5)6)30(39)34-24-8-7-21(3)27(15-24)38-19-26(35-36-38)22-13-25(18-32-16-22)37-9-11-40-12-10-37/h7-8,13-16,18-20,33H,9-12,17H2,1-6H3,(H,34,39) HQGOGKHAZOPAGY-UHFFFAOYSA-N 212389 US9290507, II-2 Serine/threonine-protein kinase B-raf Homo sapiens 14 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212389&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464283 329588239 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373926 Cc1ccc(NC(=O)c2ccc(o2)C(C)(C)C)cc1-n1cc(nn1)-c1cncc(c1)N1CCN(CC1)C(C)(C)C InChI=1S/C31H39N7O2/c1-21-8-9-23(33-29(39)27-10-11-28(40-27)30(2,3)4)17-26(21)38-20-25(34-35-38)22-16-24(19-32-18-22)36-12-14-37(15-13-36)31(5,6)7/h8-11,16-20H,12-15H2,1-7H3,(H,33,39) IZQHZWRCLXSDSI-UHFFFAOYSA-N 212390 US9290507, II-3 Serine/threonine-protein kinase B-raf Homo sapiens 3 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212390&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464284 329588240 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373927 Cc1ccc(NC(=O)c2cc(nn2C)C(C)(C)C)cc1-n1cc(nn1)-c1cncc(c1)N1CCOCC1 InChI=1S/C27H32N8O2/c1-18-6-7-20(29-26(36)24-14-25(27(2,3)4)31-33(24)5)13-23(18)35-17-22(30-32-35)19-12-21(16-28-15-19)34-8-10-37-11-9-34/h6-7,12-17H,8-11H2,1-5H3,(H,29,36) PDPFIZJINIHYOS-UHFFFAOYSA-N 212391 US9290507, II-4 Serine/threonine-protein kinase B-raf Homo sapiens 11 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212391&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464285 329588241 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373928 Cc1ccc(NC(=O)c2cc(on2)C(C)(C)C)cc1-n1cc(nn1)-c1cncc(c1)N1CCOCC1 InChI=1S/C26H29N7O3/c1-17-5-6-19(28-25(34)21-13-24(36-30-21)26(2,3)4)12-23(17)33-16-22(29-31-33)18-11-20(15-27-14-18)32-7-9-35-10-8-32/h5-6,11-16H,7-10H2,1-4H3,(H,28,34) OGHREGIWGUAILA-UHFFFAOYSA-N 212392 US9290507, II-5 Serine/threonine-protein kinase B-raf Homo sapiens 8 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212392&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464286 329588242 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373929 CN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2cc(nn2C)C(C)(C)C)ccc1C InChI=1S/C28H35N9O/c1-19-7-8-21(30-27(38)25-15-26(28(2,3)4)32-35(25)6)14-24(19)37-18-23(31-33-37)20-13-22(17-29-16-20)36-11-9-34(5)10-12-36/h7-8,13-18H,9-12H2,1-6H3,(H,30,38) LYKVGFSAFKXXRG-UHFFFAOYSA-N 212393 US9290507, II-6 Serine/threonine-protein kinase B-raf Homo sapiens 8 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212393&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89708500 329588243 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373930 CN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2cc(ccn2)C(F)(F)F)ccc1C InChI=1S/C26H25F3N8O/c1-17-3-4-20(32-25(38)22-12-19(5-6-31-22)26(27,28)29)13-24(17)37-16-23(33-34-37)18-11-21(15-30-14-18)36-9-7-35(2)8-10-36/h3-6,11-16H,7-10H2,1-2H3,(H,32,38) SHUCVICRDSHPBN-UHFFFAOYSA-N 212394 US9290507, II-7 Serine/threonine-protein kinase B-raf Homo sapiens 4 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212394&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464345 329588244 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373931 CN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2cc(on2)C(C)(C)C)ccc1C InChI=1S/C27H32N8O2/c1-18-6-7-20(29-26(36)22-14-25(37-31-22)27(2,3)4)13-24(18)35-17-23(30-32-35)19-12-21(16-28-15-19)34-10-8-33(5)9-11-34/h6-7,12-17H,8-11H2,1-5H3,(H,29,36) STWRVWDECRFHAL-UHFFFAOYSA-N 212395 US9290507, II-8 Serine/threonine-protein kinase B-raf Homo sapiens 5 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212395&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464346 329588245 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373932 Cc1cc(nn1C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1cc(nn1)-c1cncc(c1)N1CCOCC1 InChI=1S/C27H32N8O2/c1-18-6-7-21(29-26(36)23-12-19(2)35(31-23)27(3,4)5)14-25(18)34-17-24(30-32-34)20-13-22(16-28-15-20)33-8-10-37-11-9-33/h6-7,12-17H,8-11H2,1-5H3,(H,29,36) ANTPPDMHFTWHJV-UHFFFAOYSA-N 212396 US9290507, II-9 Serine/threonine-protein kinase B-raf Homo sapiens 18 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212396&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464347 329588246 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373933 Cc1ccc(NC(=O)c2cc(CN3CCCC3)c(o2)C(C)(C)C)cc1-n1cc(nn1)-c1cncc(c1)N1CCOCC1 InChI=1S/C32H39N7O3/c1-22-7-8-25(34-31(40)29-16-24(20-37-9-5-6-10-37)30(42-29)32(2,3)4)17-28(22)39-21-27(35-36-39)23-15-26(19-33-18-23)38-11-13-41-14-12-38/h7-8,15-19,21H,5-6,9-14,20H2,1-4H3,(H,34,40) PPTUNDVCQIJXJS-UHFFFAOYSA-N 212397 US9290507, II-10 Serine/threonine-protein kinase B-raf Homo sapiens 11 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212397&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464348 329588247 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373934 Cc1ccc(NC(=O)c2ccc(s2)C(C)(C)C)cc1-n1cc(nn1)-c1cncc(c1)N1CCOCC1 InChI=1S/C27H30N6O2S/c1-18-5-6-20(29-26(34)24-7-8-25(36-24)27(2,3)4)14-23(18)33-17-22(30-31-33)19-13-21(16-28-15-19)32-9-11-35-12-10-32/h5-8,13-17H,9-12H2,1-4H3,(H,29,34) VWKVMRIROVCTMY-UHFFFAOYSA-N 212398 US9290507, II-11 Serine/threonine-protein kinase B-raf Homo sapiens 10 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212398&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89708469 329588248 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373935 Cc1oc(cc1C(=O)Nc1ccc(C)c(c1)-n1cc(nn1)-c1cncc(c1)N1CCOCC1)C(C)(C)C InChI=1S/C28H32N6O3/c1-18-6-7-21(30-27(35)23-14-26(28(3,4)5)37-19(23)2)13-25(18)34-17-24(31-32-34)20-12-22(16-29-15-20)33-8-10-36-11-9-33/h6-7,12-17H,8-11H2,1-5H3,(H,30,35) MERMDEUOYAVJJE-UHFFFAOYSA-N 212399 US9290507, II-12 Serine/threonine-protein kinase B-raf Homo sapiens 15 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212399&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464408 329588249 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373936 Cc1ccc(NC(=O)c2ccc(o2)C(C)(C)C)cc1-n1cc(nn1)-c1cncc(c1)N1CCOCC1 InChI=1S/C27H30N6O3/c1-18-5-6-20(29-26(34)24-7-8-25(36-24)27(2,3)4)14-23(18)33-17-22(30-31-33)19-13-21(16-28-15-19)32-9-11-35-12-10-32/h5-8,13-17H,9-12H2,1-4H3,(H,29,34) OANDYRPVFAGGNQ-UHFFFAOYSA-N 212400 US9290507, II-13 Serine/threonine-protein kinase B-raf Homo sapiens 9 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212400&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464349 329588250 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373937 CCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2ccc(o2)C(C)(C)C)ccc1C InChI=1S/C29H35N7O2/c1-6-34-11-13-35(14-12-34)23-15-21(17-30-18-23)24-19-36(33-32-24)25-16-22(8-7-20(25)2)31-28(37)26-9-10-27(38-26)29(3,4)5/h7-10,15-19H,6,11-14H2,1-5H3,(H,31,37) XZLMUHMFGCXPNL-UHFFFAOYSA-N 212401 US9290507, II-14 Serine/threonine-protein kinase B-raf Homo sapiens 3 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212401&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464409 329588251 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373938 CN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2ccc(o2)C(C)(C)C)ccc1C InChI=1S/C28H33N7O2/c1-19-6-7-21(30-27(36)25-8-9-26(37-25)28(2,3)4)15-24(19)35-18-23(31-32-35)20-14-22(17-29-16-20)34-12-10-33(5)11-13-34/h6-9,14-18H,10-13H2,1-5H3,(H,30,36) WFRRCLUHVKVNSL-UHFFFAOYSA-N 212402 US9290507, II-15 Serine/threonine-protein kinase B-raf Homo sapiens 2 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212402&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464410 329588252 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373939 Cc1ccc(NC(=O)c2ccc(o2)C(C)(C)C)cc1-n1cc(nn1)-c1cncc(c1)N1CCN(CC2CC2)CC1 InChI=1S/C31H37N7O2/c1-21-5-8-24(33-30(39)28-9-10-29(40-28)31(2,3)4)16-27(21)38-20-26(34-35-38)23-15-25(18-32-17-23)37-13-11-36(12-14-37)19-22-6-7-22/h5,8-10,15-18,20,22H,6-7,11-14,19H2,1-4H3,(H,33,39) ZSJXOURKFXNGHD-UHFFFAOYSA-N 212403 US9290507, II-16 Serine/threonine-protein kinase B-raf Homo sapiens 2 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212403&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89708476 329588253 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373940 COCCCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2ccc(o2)C(C)(C)C)ccc1C InChI=1S/C31H39N7O3/c1-22-7-8-24(33-30(39)28-9-10-29(41-28)31(2,3)4)18-27(22)38-21-26(34-35-38)23-17-25(20-32-19-23)37-14-12-36(13-15-37)11-6-16-40-5/h7-10,17-21H,6,11-16H2,1-5H3,(H,33,39) BMSGGODTVOHPOI-UHFFFAOYSA-N 212404 US9290507, II-17 Serine/threonine-protein kinase B-raf Homo sapiens 1 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212404&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53377589 329588254 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373941 Cc1ccc(NC(=O)c2ccc(o2)C(C)(C)C)cc1-n1cc(nn1)-c1cncc(c1)N1CCN(CC=C)CC1 InChI=1S/C30H35N7O2/c1-6-11-35-12-14-36(15-13-35)24-16-22(18-31-19-24)25-20-37(34-33-25)26-17-23(8-7-21(26)2)32-29(38)27-9-10-28(39-27)30(3,4)5/h6-10,16-20H,1,11-15H2,2-5H3,(H,32,38) INXTYEBZZFBLQE-UHFFFAOYSA-N 212405 US9290507, II-18 Serine/threonine-protein kinase B-raf Homo sapiens 5 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212405&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89708498 329588255 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373942 CC(C)CN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2ccc(o2)C(C)(C)C)ccc1C InChI=1S/C31H39N7O2/c1-21(2)19-36-11-13-37(14-12-36)25-15-23(17-32-18-25)26-20-38(35-34-26)27-16-24(8-7-22(27)3)33-30(39)28-9-10-29(40-28)31(4,5)6/h7-10,15-18,20-21H,11-14,19H2,1-6H3,(H,33,39) OEBCPIXHQFRWGF-UHFFFAOYSA-N 212406 US9290507, II-19 Serine/threonine-protein kinase B-raf Homo sapiens 5 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212406&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464411 329588256 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373943 Cc1ccc(NC(=O)c2ccc(o2)C(C)(C)C)cc1-n1cc(nn1)-c1cncc(c1)N1CCNCC1 InChI=1S/C27H31N7O2/c1-18-5-6-20(30-26(35)24-7-8-25(36-24)27(2,3)4)14-23(18)34-17-22(31-32-34)19-13-21(16-29-15-19)33-11-9-28-10-12-33/h5-8,13-17,28H,9-12H2,1-4H3,(H,30,35) SEUPGAKGRSBRCW-UHFFFAOYSA-N 212408 US9290507, II-21 Serine/threonine-protein kinase B-raf Homo sapiens 1 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212408&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464412 329588257 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373944 CCOCCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2ccc(o2)C(C)(C)C)ccc1C InChI=1S/C31H39N7O3/c1-6-40-16-15-36-11-13-37(14-12-36)25-17-23(19-32-20-25)26-21-38(35-34-26)27-18-24(8-7-22(27)2)33-30(39)28-9-10-29(41-28)31(3,4)5/h7-10,17-21H,6,11-16H2,1-5H3,(H,33,39) BGBXTHZJYAZJHZ-UHFFFAOYSA-N 212409 US9290507, II-22 Serine/threonine-protein kinase B-raf Homo sapiens 7 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212409&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89708477 329588258 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373945 Cc1ccc(NC(=O)c2ccc(s2)C(C)(C)C)cc1-n1cc(nn1)-c1cncc(c1)N1CCN(CC1)C(=O)OC(C)(C)C InChI=1S/C32H39N7O3S/c1-21-8-9-23(34-29(40)27-10-11-28(43-27)31(2,3)4)17-26(21)39-20-25(35-36-39)22-16-24(19-33-18-22)37-12-14-38(15-13-37)30(41)42-32(5,6)7/h8-11,16-20H,12-15H2,1-7H3,(H,34,40) MLHNVFBXMVJJLI-UHFFFAOYSA-N 212410 US9290507, II-23 Serine/threonine-protein kinase B-raf Homo sapiens 141 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212410&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464471 329588259 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373946 Cc1ccc(NC(=O)c2ccc(s2)C(C)(C)C)cc1-n1cc(nn1)-c1cncc(c1)N1CCNCC1 InChI=1S/C27H31N7OS/c1-18-5-6-20(30-26(35)24-7-8-25(36-24)27(2,3)4)14-23(18)34-17-22(31-32-34)19-13-21(16-29-15-19)33-11-9-28-10-12-33/h5-8,13-17,28H,9-12H2,1-4H3,(H,30,35) HACIXPOSBVOXEL-UHFFFAOYSA-N 212411 US9290507, II-24 Serine/threonine-protein kinase B-raf Homo sapiens 4 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212411&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89708456 329588260 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373947 CCCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2ccc(s2)C(C)(C)C)ccc1C InChI=1S/C30H37N7OS/c1-6-11-35-12-14-36(15-13-35)24-16-22(18-31-19-24)25-20-37(34-33-25)26-17-23(8-7-21(26)2)32-29(38)27-9-10-28(39-27)30(3,4)5/h7-10,16-20H,6,11-15H2,1-5H3,(H,32,38) KQRPDWKSTBEUSO-UHFFFAOYSA-N 212412 US9290507, II-25 Serine/threonine-protein kinase B-raf Homo sapiens 9 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212412&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464472 329588261 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373948 CN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2ccc(s2)C(C)(C)C)ccc1C InChI=1S/C28H33N7OS/c1-19-6-7-21(30-27(36)25-8-9-26(37-25)28(2,3)4)15-24(19)35-18-23(31-32-35)20-14-22(17-29-16-20)34-12-10-33(5)11-13-34/h6-9,14-18H,10-13H2,1-5H3,(H,30,36) PVNXSWRTWUFNTA-UHFFFAOYSA-N 212413 US9290507, II-26 Serine/threonine-protein kinase B-raf Homo sapiens 6 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212413&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464600 329588262 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373949 CCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2ccc(s2)C(C)(C)C)ccc1C InChI=1S/C29H35N7OS/c1-6-34-11-13-35(14-12-34)23-15-21(17-30-18-23)24-19-36(33-32-24)25-16-22(8-7-20(25)2)31-28(37)26-9-10-27(38-26)29(3,4)5/h7-10,15-19H,6,11-14H2,1-5H3,(H,31,37) HAOJZJCOHCASES-UHFFFAOYSA-N 212414 US9290507, II-27 Serine/threonine-protein kinase B-raf Homo sapiens 8 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212414&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89708455 329588263 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373950 CCOCCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2ccc(s2)C(C)(C)C)ccc1C InChI=1S/C31H39N7O2S/c1-6-40-16-15-36-11-13-37(14-12-36)25-17-23(19-32-20-25)26-21-38(35-34-26)27-18-24(8-7-22(27)2)33-30(39)28-9-10-29(41-28)31(3,4)5/h7-10,17-21H,6,11-16H2,1-5H3,(H,33,39) TVSWHNSYRVEPPY-UHFFFAOYSA-N 212415 US9290507, II-28 Serine/threonine-protein kinase B-raf Homo sapiens 10 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212415&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464473 329588264 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373951 Cc1ccc(NC(=O)c2ccc(s2)C(C)(C)C)cc1-n1cc(nn1)-c1cncc(c1)N1CCN(CC1)C(C)(C)C InChI=1S/C31H39N7OS/c1-21-8-9-23(33-29(39)27-10-11-28(40-27)30(2,3)4)17-26(21)38-20-25(34-35-38)22-16-24(19-32-18-22)36-12-14-37(15-13-36)31(5,6)7/h8-11,16-20H,12-15H2,1-7H3,(H,33,39) IDIJELODJIRWPS-UHFFFAOYSA-N 212416 US9290507, II-29 Serine/threonine-protein kinase B-raf Homo sapiens 10 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212416&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89708479 329588265 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373952 CC(C)CN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2ccc(s2)C(C)(C)C)ccc1C InChI=1S/C31H39N7OS/c1-21(2)19-36-11-13-37(14-12-36)25-15-23(17-32-18-25)26-20-38(35-34-26)27-16-24(8-7-22(27)3)33-30(39)28-9-10-29(40-28)31(4,5)6/h7-10,15-18,20-21H,11-14,19H2,1-6H3,(H,33,39) BRAYPKRMEFDMKJ-UHFFFAOYSA-N 212417 US9290507, II-30 Serine/threonine-protein kinase B-raf Homo sapiens 18 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212417&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464474 329588266 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373953 Cc1ccc(NC(=O)c2ccc(s2)C(C)(C)C)cc1-n1cc(nn1)-c1cncc(c1)N1CCN(CC2CC2)CC1 InChI=1S/C31H37N7OS/c1-21-5-8-24(33-30(39)28-9-10-29(40-28)31(2,3)4)16-27(21)38-20-26(34-35-38)23-15-25(18-32-17-23)37-13-11-36(12-14-37)19-22-6-7-22/h5,8-10,15-18,20,22H,6-7,11-14,19H2,1-4H3,(H,33,39) YKWHLKQEJOUDPQ-UHFFFAOYSA-N 212418 US9290507, II-31 Serine/threonine-protein kinase B-raf Homo sapiens 8 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212418&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700830 329588267 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373954 Cc1ccc(NC(=O)c2ccc(s2)C(C)(C)C)cc1-n1cc(nn1)-c1cncc(c1)N1CCN(CC=C)CC1 InChI=1S/C30H35N7OS/c1-6-11-35-12-14-36(15-13-35)24-16-22(18-31-19-24)25-20-37(34-33-25)26-17-23(8-7-21(26)2)32-29(38)27-9-10-28(39-27)30(3,4)5/h6-10,16-20H,1,11-15H2,2-5H3,(H,32,38) MEQVRVHDKIKGJC-UHFFFAOYSA-N 212419 US9290507, II-32 Serine/threonine-protein kinase B-raf Homo sapiens 13 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212419&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464475 329588268 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373955 COCCCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2ccc(s2)C(C)(C)C)ccc1C InChI=1S/C31H39N7O2S/c1-22-7-8-24(33-30(39)28-9-10-29(41-28)31(2,3)4)18-27(22)38-21-26(34-35-38)23-17-25(20-32-19-23)37-14-12-36(13-15-37)11-6-16-40-5/h7-10,17-21H,6,11-16H2,1-5H3,(H,33,39) SGNZPOHNKGXXOZ-UHFFFAOYSA-N 212420 US9290507, II-33 Serine/threonine-protein kinase B-raf Homo sapiens 7 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212420&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464534 329588269 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373956 Cc1cc(nn1C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1cc(nn1)-c1cncc(c1)N1CCN(CC1)C1CC1 InChI=1S/C30H37N9O/c1-20-6-7-23(32-29(40)26-14-21(2)39(34-26)30(3,4)5)16-28(20)38-19-27(33-35-38)22-15-25(18-31-17-22)37-12-10-36(11-13-37)24-8-9-24/h6-7,14-19,24H,8-13H2,1-5H3,(H,32,40) WGBJKDQAFDGCEL-UHFFFAOYSA-N 212421 US9290507, II-34 Serine/threonine-protein kinase B-raf Homo sapiens 31 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212421&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464535 329588270 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373957 CCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2cc(C)n(n2)C(C)(C)C)ccc1C InChI=1S/C29H37N9O/c1-7-35-10-12-36(13-11-35)24-15-22(17-30-18-24)26-19-37(34-32-26)27-16-23(9-8-20(27)2)31-28(39)25-14-21(3)38(33-25)29(4,5)6/h8-9,14-19H,7,10-13H2,1-6H3,(H,31,39) DEJMGHGOVBKMRV-UHFFFAOYSA-N 212422 US9290507, II-35 Serine/threonine-protein kinase B-raf Homo sapiens 10 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212422&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67403922 329588271 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373958 CC(C)N1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2cc(C)n(n2)C(C)(C)C)ccc1C InChI=1S/C30H39N9O/c1-20(2)36-10-12-37(13-11-36)25-15-23(17-31-18-25)27-19-38(35-33-27)28-16-24(9-8-21(28)3)32-29(40)26-14-22(4)39(34-26)30(5,6)7/h8-9,14-20H,10-13H2,1-7H3,(H,32,40) UXONOBNMDRJULU-UHFFFAOYSA-N 212423 US9290507, II-36 Serine/threonine-protein kinase B-raf Homo sapiens 13 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212423&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464536 329588272 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373959 CCCN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2cc(C)n(n2)C(C)(C)C)ccc1C InChI=1S/C30H39N9O/c1-7-10-36-11-13-37(14-12-36)25-16-23(18-31-19-25)27-20-38(35-33-27)28-17-24(9-8-21(28)2)32-29(40)26-15-22(3)39(34-26)30(4,5)6/h8-9,15-20H,7,10-14H2,1-6H3,(H,32,40) KQCBRFGFPKTOMU-UHFFFAOYSA-N 212424 US9290507, II-37 Serine/threonine-protein kinase B-raf Homo sapiens 11 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212424&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67404522 329588273 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373960 CN1CCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2cc(C)n(n2)C(C)(C)C)ccc1C InChI=1S/C28H35N9O/c1-19-7-8-22(30-27(38)24-13-20(2)37(32-24)28(3,4)5)15-26(19)36-18-25(31-33-36)21-14-23(17-29-16-21)35-11-9-34(6)10-12-35/h7-8,13-18H,9-12H2,1-6H3,(H,30,38) FXZNMBUEUHWGGH-UHFFFAOYSA-N 212425 US9290507, II-38 Serine/threonine-protein kinase B-raf Homo sapiens 11 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212425&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464537 329588274 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373961 CN1CCCN(CC1)c1cncc(c1)-c1cn(nn1)-c1cc(NC(=O)c2cc(C)n(n2)C(C)(C)C)ccc1C InChI=1S/C29H37N9O/c1-20-8-9-23(31-28(39)25-14-21(2)38(33-25)29(3,4)5)16-27(20)37-19-26(32-34-37)22-15-24(18-30-17-22)36-11-7-10-35(6)12-13-36/h8-9,14-19H,7,10-13H2,1-6H3,(H,31,39) UJJXAOMDFCWDMI-UHFFFAOYSA-N 212426 US9290507, II-39 Serine/threonine-protein kinase B-raf Homo sapiens 9 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212426&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464599 329588275 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373962 Cc1ccc(NC(=O)c2cc(CNC(C)(C)C)c(o2)C(C)(C)C)cc1-n1cc(nn1)-c1cncc(c1)N1CCOCC1 InChI=1S/C32H41N7O3/c1-21-8-9-24(35-30(40)28-15-23(18-34-32(5,6)7)29(42-28)31(2,3)4)16-27(21)39-20-26(36-37-39)22-14-25(19-33-17-22)38-10-12-41-13-11-38/h8-9,14-17,19-20,34H,10-13,18H2,1-7H3,(H,35,40) TXAINDWEDLELPZ-UHFFFAOYSA-N 212427 US9290507, II-40 Serine/threonine-protein kinase B-raf Homo sapiens 11 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212427&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89700965 329588276 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373963 CN1CCC(CC1)NCc1cc(oc1C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1cc(nn1)-c1cncc(c1)N1CCOCC1 InChI=1S/C34H44N8O3/c1-23-6-7-27(18-30(23)42-22-29(38-39-42)24-16-28(21-35-19-24)41-12-14-44-15-13-41)37-33(43)31-17-25(32(45-31)34(2,3)4)20-36-26-8-10-40(5)11-9-26/h6-7,16-19,21-22,26,36H,8-15,20H2,1-5H3,(H,37,43) AADXGJWDXHLDDI-UHFFFAOYSA-N 212428 US9290507, II-41 Serine/threonine-protein kinase B-raf Homo sapiens 14 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212428&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67403093 329588277 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373964 CN1CCN(Cc2cc(oc2C(C)(C)C)C(=O)Nc2ccc(C)c(c2)-n2cc(nn2)-c2cncc(c2)N2CCOCC2)CC1 InChI=1S/C33H42N8O3/c1-23-6-7-26(35-32(42)30-17-25(31(44-30)33(2,3)4)21-39-10-8-38(5)9-11-39)18-29(23)41-22-28(36-37-41)24-16-27(20-34-19-24)40-12-14-43-15-13-40/h6-7,16-20,22H,8-15,21H2,1-5H3,(H,35,42) QXPXRBCJHNJSGR-UHFFFAOYSA-N 212429 US9290507, II-42 Serine/threonine-protein kinase B-raf Homo sapiens 16 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212429&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464538 329588278 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373965 CN(C)CCN(C)Cc1cc(oc1C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1cc(nn1)-c1cncc(c1)N1CCOCC1 InChI=1S/C33H44N8O3/c1-23-8-9-26(35-32(42)30-17-25(31(44-30)33(2,3)4)21-39(7)11-10-38(5)6)18-29(23)41-22-28(36-37-41)24-16-27(20-34-19-24)40-12-14-43-15-13-40/h8-9,16-20,22H,10-15,21H2,1-7H3,(H,35,42) YSTQIVKZEYNVNQ-UHFFFAOYSA-N 212430 US9290507, II-43 Serine/threonine-protein kinase B-raf Homo sapiens 36 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212430&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464596 329588279 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373966 CN(C)Cc1cc(oc1C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1cc(nn1)-c1cncc(c1)N1CCOCC1 InChI=1S/C30H37N7O3/c1-20-7-8-23(32-29(38)27-14-22(18-35(5)6)28(40-27)30(2,3)4)15-26(20)37-19-25(33-34-37)21-13-24(17-31-16-21)36-9-11-39-12-10-36/h7-8,13-17,19H,9-12,18H2,1-6H3,(H,32,38) AMXIPLKCYBIJDI-UHFFFAOYSA-N 212431 US9290507, II-44 Serine/threonine-protein kinase B-raf Homo sapiens 11 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212431&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464597 329588280 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 373967 CN(C)CCNCc1cc(oc1C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1cc(nn1)-c1cncc(c1)N1CCOCC1 InChI=1S/C32H42N8O3/c1-22-7-8-25(35-31(41)29-16-24(19-33-9-10-38(5)6)30(43-29)32(2,3)4)17-28(22)40-21-27(36-37-40)23-15-26(20-34-18-23)39-11-13-42-14-12-39/h7-8,15-18,20-21,33H,9-14,19H2,1-6H3,(H,35,41) KPDJXLXGMBROEU-UHFFFAOYSA-N 212432 US9290507, II-45 Serine/threonine-protein kinase B-raf Homo sapiens 10 7.5 US Patent 10.7270/Q2PK0F1H aid1802372 US9290507 Steurer, S; Ettmayer, P; Mantoulidis, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212432&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53464598 329588281 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388186 COC(=O)N[C@@H](C)CNc1nccc(n1)-c1cn(nc1-c1cc(Cl)cc(NS(C)(=O)=O)c1)C(C)C InChI=1S/C22H28ClN7O4S/c1-13(2)30-12-18(19-6-7-24-21(27-19)25-11-14(3)26-22(31)34-4)20(28-30)15-8-16(23)10-17(9-15)29-35(5,32)33/h6-10,12-14,29H,11H2,1-5H3,(H,26,31)(H,24,25,27)/t14-/m0/s1 AZFXVYSHIJAZOU-AWEZNQCLSA-N 221681 US10568884, Cpd 2::US9314464, 2::US9593100, Compound 2::USRE49556, Compound 2 Serine/threonine-protein kinase B-raf Homo sapiens 0.8 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221681&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51033570 335960650 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388187 COC(=O)N[C@@H](C)CNc1nccc(n1)-c1cn(nc1-c1cccc(NS(C)(=O)=O)c1F)C(C)C InChI=1S/C22H28FN7O4S/c1-13(2)30-12-16(17-9-10-24-21(27-17)25-11-14(3)26-22(31)34-4)20(28-30)15-7-6-8-18(19(15)23)29-35(5,32)33/h6-10,12-14,29H,11H2,1-5H3,(H,26,31)(H,24,25,27)/t14-/m0/s1 FCSQNBKYSFKSHZ-AWEZNQCLSA-N 221683 US10568884, Cpd 4::US9314464, 4::US9593100, Compound 4::USRE49556, Compound 4 Serine/threonine-protein kinase B-raf Homo sapiens 2.3 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221683&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51033572 335960651 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388188 CCCS(=O)(=O)Nc1cc(Cl)cc(c1)-c1nn(cc1-c1ccnc(NC[C@H](C)NC(=O)OC)n1)C(C)C InChI=1S/C24H32ClN7O4S/c1-6-9-37(34,35)31-19-11-17(10-18(25)12-19)22-20(14-32(30-22)15(2)3)21-7-8-26-23(29-21)27-13-16(4)28-24(33)36-5/h7-8,10-12,14-16,31H,6,9,13H2,1-5H3,(H,28,33)(H,26,27,29)/t16-/m0/s1 PCDHTILQESNIQQ-INIZCTEOSA-N 221684 US10568884, Cpd 5::US9314464, 5::US9593100, Compound 5::USRE49556, Compound 5 Serine/threonine-protein kinase B-raf Homo sapiens 0.2 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221684&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51033573 335960652 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388189 COC(=O)N[C@@H](C)CNc1nccc(n1)-c1cn(nc1-c1c(F)ccc(NS(C)(=O)=O)c1F)C(C)C InChI=1S/C22H27F2N7O4S/c1-12(2)31-11-14(16-8-9-25-21(28-16)26-10-13(3)27-22(32)35-4)20(29-31)18-15(23)6-7-17(19(18)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1 MKCVFAPLFKXTKT-ZDUSSCGKSA-N 221685 US10568884, Cpd 6::US9314464, 6::US9593100, Compound 6::USRE49556, Compound 6 Serine/threonine-protein kinase B-raf Homo sapiens 3.9 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221685&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51033574 335960653 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388190 CCCS(=O)(=O)Nc1ccc(F)c(-c2nn(cc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)C(C)C)c1F InChI=1S/C24H31F2N7O4S/c1-6-11-38(35,36)32-19-8-7-17(25)20(21(19)26)22-16(13-33(31-22)14(2)3)18-9-10-27-23(30-18)28-12-15(4)29-24(34)37-5/h7-10,13-15,32H,6,11-12H2,1-5H3,(H,29,34)(H,27,28,30)/t15-/m0/s1 BEPGTMTXHVYWRS-HNNXBMFYSA-N 221686 US10568884, Cpd 7::US9314464, 7::US9593100, Compound 7::USRE49556, Compound 7 Serine/threonine-protein kinase B-raf Homo sapiens 0.7 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221686&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51033681 335960654 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388191 COC(=O)N[C@@H](C)CNc1nccc(n1)-c1cn(nc1-c1cc(Cl)cc(NS(C)(=O)=O)c1F)C(C)C InChI=1S/C22H27ClFN7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)26-10-13(3)27-22(32)35-4)20(29-31)15-8-14(23)9-18(19(15)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1 CMJCXYNUCSMDBY-ZDUSSCGKSA-N 221688 US10568884, Cpd 9::US9314464, 9::US9593100, Compound 9::USRE49556, Compound 9 Serine/threonine-protein kinase B-raf Homo sapiens 0.3 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221688&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 50922675 335960655 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388192 COC(=O)N[C@@H](C)CNc1nccc(n1)-c1cn(nc1-c1cc(F)cc(NS(C)(=O)=O)c1F)C(C)C InChI=1S/C22H27F2N7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)26-10-13(3)27-22(32)35-4)20(29-31)15-8-14(23)9-18(19(15)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1 IDDGSCPILQDMST-ZDUSSCGKSA-N 221689 US10568884, Cpd 10::US9314464, 10::US9593100, Compound 10::USRE49556, Compound 10 Serine/threonine-protein kinase B-raf Homo sapiens 0.6 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221689&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51033912 335960656 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388193 CCn1cc(c(n1)-c1cc(Cl)cc(NS(C)(=O)=O)c1F)-c1ccnc(NC[C@H](C)NC(=O)OC)n1 InChI=1S/C21H25ClFN7O4S/c1-5-30-11-15(16-6-7-24-20(27-16)25-10-12(2)26-21(31)34-3)19(28-30)14-8-13(22)9-17(18(14)23)29-35(4,32)33/h6-9,11-12,29H,5,10H2,1-4H3,(H,26,31)(H,24,25,27)/t12-/m0/s1 XVXYXUQCGWHPKG-LBPRGKRZSA-N 221690 US10568884, Cpd 11::US9314464, 11::US9593100, Compound 11::USRE49556, Compound 11 Serine/threonine-protein kinase B-raf Homo sapiens 0.5 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221690&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51034011 335960657 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388194 COC(=O)N[C@@H](C)CNc1nccc(n1)-c1cn(nc1-c1cc(C)cc(NS(C)(=O)=O)c1F)C(C)C InChI=1S/C23H30FN7O4S/c1-13(2)31-12-17(18-7-8-25-22(28-18)26-11-15(4)27-23(32)35-5)21(29-31)16-9-14(3)10-19(20(16)24)30-36(6,33)34/h7-10,12-13,15,30H,11H2,1-6H3,(H,27,32)(H,25,26,28)/t15-/m0/s1 FOKYULGGOAAGRF-HNNXBMFYSA-N 221691 US10568884, Cpd 12::US9314464, 12::US9593100, Compound 12::USRE49556, Compound 12 Serine/threonine-protein kinase B-raf Homo sapiens 0.95 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221691&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51034012 335960658 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388195 COC(=O)N[C@@H](C)CNc1nccc(n1)-c1cn(nc1-c1cc(C)cc(NS(C)(=O)=O)c1Cl)C(C)C InChI=1S/C23H30ClN7O4S/c1-13(2)31-12-17(18-7-8-25-22(28-18)26-11-15(4)27-23(32)35-5)21(29-31)16-9-14(3)10-19(20(16)24)30-36(6,33)34/h7-10,12-13,15,30H,11H2,1-6H3,(H,27,32)(H,25,26,28)/t15-/m0/s1 YIEWFBJIVDMNJO-HNNXBMFYSA-N 221692 US10568884, Cpd 13::US9314464, 13::US9593100, Compound 13::USRE49556, Compound 13 Serine/threonine-protein kinase B-raf Homo sapiens 1 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221692&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51034013 335960659 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388196 COC(=O)N[C@@H](C)CNc1nccc(n1)-c1cn(nc1-c1cc(F)cc(NS(C)(=O)=O)c1Cl)C(C)C InChI=1S/C22H27ClFN7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)26-10-13(3)27-22(32)35-4)20(29-31)15-8-14(24)9-18(19(15)23)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1 ZKZGAMDUVHYNPH-ZDUSSCGKSA-N 221694 US10568884, Cpd 15::US9314464, 15::US9593100, Compound 15::USRE49556, Compound 15 Serine/threonine-protein kinase B-raf Homo sapiens 1.1 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221694&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51034014 335960660 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388197 COC(=O)N[C@@H](C)CNc1nccc(n1)-c1cn(nc1-c1ccnc(NS(C)(=O)=O)c1F)C(C)C InChI=1S/C21H27FN8O4S/c1-12(2)30-11-15(16-7-9-24-20(27-16)25-10-13(3)26-21(31)34-4)18(28-30)14-6-8-23-19(17(14)22)29-35(5,32)33/h6-9,11-13H,10H2,1-5H3,(H,23,29)(H,26,31)(H,24,25,27)/t13-/m0/s1 BEJNUMRZYPYGDM-ZDUSSCGKSA-N 221695 US10568884, Cpd 16::US9314464, 16::US9593100, Compound 16::USRE49556, Compound 16 Serine/threonine-protein kinase B-raf Homo sapiens 24 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221695&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51033684 335960661 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388198 COC(=O)N[C@@H](C)CNc1nccc(n1)-c1cn(nc1-c1ccc(F)c(NS(C)(=O)=O)c1F)C(C)C InChI=1S/C22H27F2N7O4S/c1-12(2)31-11-15(17-8-9-25-21(28-17)26-10-13(3)27-22(32)35-4)19(29-31)14-6-7-16(23)20(18(14)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1 SJTRSVMDXLVDFY-ZDUSSCGKSA-N 221698 US10568884, Cpd 19::US9314464, 19::US9593100, Compound 19::USRE49556, Compound 19 Serine/threonine-protein kinase B-raf Homo sapiens 6.1 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221698&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51033800 335960662 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388199 COC(=O)N[C@H](C)CNc1nccc(n1)-c1cn(nc1-c1cc(Cl)cc(NS(C)(=O)=O)c1F)C(C)C InChI=1S/C22H27ClFN7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)26-10-13(3)27-22(32)35-4)20(29-31)15-8-14(23)9-18(19(15)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m1/s1 CMJCXYNUCSMDBY-CYBMUJFWSA-N 221699 US10568884, Cpd 20::US9314464, 20::US9593100, Compound 20::USRE49556, Compound 20 Serine/threonine-protein kinase B-raf Homo sapiens 0.8 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221699&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51034015 335960663 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388200 CCS(=O)(=O)Nc1c(F)ccc(-c2nn(cc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)C(C)C)c1F InChI=1S/C23H29F2N7O4S/c1-6-37(34,35)31-21-17(24)8-7-15(19(21)25)20-16(12-32(30-20)13(2)3)18-9-10-26-22(29-18)27-11-14(4)28-23(33)36-5/h7-10,12-14,31H,6,11H2,1-5H3,(H,28,33)(H,26,27,29)/t14-/m0/s1 MISNBEQFUJYEAG-AWEZNQCLSA-N 221705 US10568884, Cpd 26::US9314464, 26::US9593100, Compound 26::USRE49556, Compound 26 Serine/threonine-protein kinase B-raf Homo sapiens 1.7 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221705&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51033803 335960664 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388201 COC(=O)N[C@@H](C)CNc1nccc(n1)-c1cn(nc1-c1cc(NS(C)(=O)=O)c(C)c(OC)c1)C(C)C InChI=1S/C24H33N7O5S/c1-14(2)31-13-18(19-8-9-25-23(28-19)26-12-15(3)27-24(32)36-6)22(29-31)17-10-20(30-37(7,33)34)16(4)21(11-17)35-5/h8-11,13-15,30H,12H2,1-7H3,(H,27,32)(H,25,26,28)/t15-/m0/s1 SISWDKICRBYYDV-HNNXBMFYSA-N 221706 US10568884, Cpd 27::US9314464, 27::US9593100, Compound 27::USRE49556, Compound 27 Serine/threonine-protein kinase B-raf Homo sapiens 390 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221706&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 58553836 335960665 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388202 CC(C)n1cc(c(n1)-c1cc(Cl)cc(NS(C)(=O)=O)c1F)-c1ccnc(NCCN(C)C)n1 InChI=1S/C21H27ClFN7O2S/c1-13(2)30-12-16(17-6-7-24-21(26-17)25-8-9-29(3)4)20(27-30)15-10-14(22)11-18(19(15)23)28-33(5,31)32/h6-7,10-13,28H,8-9H2,1-5H3,(H,24,25,26) XHBPQUQPPQNMMJ-UHFFFAOYSA-N 221707 US10568884, Cpd 28::US9314464, 28::US9593100, Compound 28::USRE49556, Compound 28 Serine/threonine-protein kinase B-raf Homo sapiens 90 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221707&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51034123 335960666 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388203 CNc1nccc(n1)-c1cn(nc1-c1cc(Cl)cc(NS(C)(=O)=O)c1F)C(C)C InChI=1S/C18H20ClFN6O2S/c1-10(2)26-9-13(14-5-6-22-18(21-3)23-14)17(24-26)12-7-11(19)8-15(16(12)20)25-29(4,27)28/h5-10,25H,1-4H3,(H,21,22,23) LDNRMMCYKPMHQR-UHFFFAOYSA-N 221708 US10568884, Cpd 29::US9314464, 29::US9593100, Compound 29::USRE49556, Compound 29 Serine/threonine-protein kinase B-raf Homo sapiens 8 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221708&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51034124 335960667 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388204 CC(C)n1cc(c(n1)-c1cc(Cl)cc(NS(C)(=O)=O)c1F)-c1ccnc(N)n1 InChI=1S/C17H18ClFN6O2S/c1-9(2)25-8-12(13-4-5-21-17(20)22-13)16(23-25)11-6-10(18)7-14(15(11)19)24-28(3,26)27/h4-9,24H,1-3H3,(H2,20,21,22) XRCYSJXOEWSFPE-UHFFFAOYSA-N 221709 US10568884, Cpd 30::US9314464, 30::US9593100, Compound 30::USRE49556, Compound 30 Serine/threonine-protein kinase B-raf Homo sapiens 4.3 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221709&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51034125 335960668 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388205 COC(=O)N[C@@H](C)CNc1nccc(n1)-c1c[nH]nc1-c1cc(Cl)cc(NS(C)(=O)=O)c1F 221710 US10568884, Cpd 31::US9314464, 31::US9593100, Compound 31::USRE49556, Compound 31 Serine/threonine-protein kinase B-raf Homo sapiens 0.8 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221710&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 126842507 335960669 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388206 COC(=O)NC[C@H](C)Nc1nccc(n1)-c1cn(nc1-c1cc(Cl)cc(NS(C)(=O)=O)c1F)C(C)C InChI=1S/C22H27ClFN7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)27-13(3)10-26-22(32)35-4)20(29-31)15-8-14(23)9-18(19(15)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,26,32)(H,25,27,28)/t13-/m0/s1 HKXKEELLDFNXRA-ZDUSSCGKSA-N 221711 US10568884, Cpd 32::US9314464, 32::US9593100, Compound 32::USRE49556, Compound 32 Serine/threonine-protein kinase B-raf Homo sapiens 2.9 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221711&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51033804 335960670 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 388207 CCCS(=O)(=O)Nc1c(F)ccc(-c2nn(cc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)C(C)C)c1F InChI=1S/C24H31F2N7O4S/c1-6-11-38(35,36)32-22-18(25)8-7-16(20(22)26)21-17(13-33(31-21)14(2)3)19-9-10-27-23(30-19)28-12-15(4)29-24(34)37-5/h7-10,13-15,32H,6,11-12H2,1-5H3,(H,29,34)(H,27,28,30)/t15-/m0/s1 GTVBBDKLBUVTKF-HNNXBMFYSA-N 221713 US10568884, Cpd 34::US9314464, 34::US9593100, Compound 34::USRE49556, Compound 34 Serine/threonine-protein kinase B-raf Homo sapiens 2.7 7.5 25.00 C US Patent 10.7270/Q2J67FS0 aid1802562 US9314464 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Novartis AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221713&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51033908 335960671 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410268 Cc1cc(Oc2cc(NC(=O)C3CC3)ncn2)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F InChI=1S/C23H19ClF3N5O3/c1-12-8-15(35-20-10-19(28-11-29-20)32-21(33)13-2-3-13)5-7-18(12)31-22(34)30-14-4-6-17(24)16(9-14)23(25,26)27/h4-11,13H,2-3H2,1H3,(H2,30,31,34)(H,28,29,32,33) DJRJTXSOXZTTSQ-UHFFFAOYSA-N 235391 US9359338, Exe. 001 Serine/threonine-protein kinase B-raf Homo sapiens 39 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235391&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 72945584 340095054 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410269 FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3cc(NC(=O)C4CC4)ncn3)cc2)ccc1Cl InChI=1S/C22H17ClF3N5O3/c23-17-8-5-14(9-16(17)22(24,25)26)30-21(33)29-13-3-6-15(7-4-13)34-19-10-18(27-11-28-19)31-20(32)12-1-2-12/h3-12H,1-2H2,(H2,29,30,33)(H,27,28,31,32) VJXYXBNJVZLNDH-UHFFFAOYSA-N 235397 US9359338, Exe. 007 Serine/threonine-protein kinase B-raf Homo sapiens 24.8 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235397&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233877 340095060 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410270 Fc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)ccc1Oc1cc(NC(=O)C2CC2)ncn1 InChI=1S/C22H16ClF4N5O3/c23-15-5-3-12(7-14(15)22(25,26)27)30-21(34)31-13-4-6-17(16(24)8-13)35-19-9-18(28-10-29-19)32-20(33)11-1-2-11/h3-11H,1-2H2,(H2,30,31,34)(H,28,29,32,33) OILFPGHQSJVKOB-UHFFFAOYSA-N 235398 US9359338, Exe. 008 Serine/threonine-protein kinase B-raf Homo sapiens 24.9 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235398&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233879 340095061 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410271 Fc1cc(Oc2cc(NC(=O)C3CC3)ncn2)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F InChI=1S/C22H16ClF4N5O3/c23-15-5-3-12(7-14(15)22(25,26)27)30-21(34)31-17-6-4-13(8-16(17)24)35-19-9-18(28-10-29-19)32-20(33)11-1-2-11/h3-11H,1-2H2,(H2,30,31,34)(H,28,29,32,33) BQXWKDUCYCISEQ-UHFFFAOYSA-N 235399 US9359338, Exe. 009 Serine/threonine-protein kinase B-raf Homo sapiens 26 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235399&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233878 340095062 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410272 Cc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)ccc1Oc1cc(NC(=O)C2CC2)ncn1 InChI=1S/C23H19ClF3N5O3/c1-12-8-14(30-22(34)31-15-4-6-17(24)16(9-15)23(25,26)27)5-7-18(12)35-20-10-19(28-11-29-20)32-21(33)13-2-3-13/h4-11,13H,2-3H2,1H3,(H2,30,31,34)(H,28,29,32,33) ZDIBAWFHWRSKFC-UHFFFAOYSA-N 235400 US9359338, Exe. 010 Serine/threonine-protein kinase B-raf Homo sapiens 97 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235400&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 72945586 340095063 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410273 Cc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cnc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C23H19ClF3N5O3/c1-12-8-15(31-22(34)30-14-4-5-18(24)17(9-14)23(25,26)27)11-29-21(12)35-16-6-7-28-19(10-16)32-20(33)13-2-3-13/h4-11,13H,2-3H2,1H3,(H,28,32,33)(H2,30,31,34) QBLQFPPLGKWCTC-UHFFFAOYSA-N 235407 US9359338, Exe. 017 Serine/threonine-protein kinase B-raf Homo sapiens 15.7 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235407&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233835 340095070 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410274 FC(F)(F)c1cc(NC(=O)Nc2cnc(Oc3ccnc(NC(=O)C4CC4)c3)c(Cl)c2)ccc1Cl InChI=1S/C22H16Cl2F3N5O3/c23-16-4-3-12(7-15(16)22(25,26)27)30-21(34)31-13-8-17(24)20(29-10-13)35-14-5-6-28-18(9-14)32-19(33)11-1-2-11/h3-11H,1-2H2,(H,28,32,33)(H2,30,31,34) OABCTVGILTVQAC-UHFFFAOYSA-N 235409 US9359338, Exe. 019 Serine/threonine-protein kinase B-raf Homo sapiens 18.1 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235409&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233963 340095072 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410275 FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)nc2)ccc1Cl InChI=1S/C22H17ClF3N5O3/c23-17-5-3-13(9-16(17)22(24,25)26)29-21(33)30-14-4-6-19(28-11-14)34-15-7-8-27-18(10-15)31-20(32)12-1-2-12/h3-12H,1-2H2,(H,27,31,32)(H2,29,30,33) LDYYUUDPUXWYDF-UHFFFAOYSA-N 235410 US9359338, Exe. 020 Serine/threonine-protein kinase B-raf Homo sapiens 19.7 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235410&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233789 340095073 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410276 FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cn2)ccc1Cl InChI=1S/C22H17ClF3N5O3/c23-17-5-3-13(9-16(17)22(24,25)26)29-21(33)31-18-6-4-15(11-28-18)34-14-7-8-27-19(10-14)30-20(32)12-1-2-12/h3-12H,1-2H2,(H,27,30,32)(H2,28,29,31,33) BVFGQAAEFGLNAJ-UHFFFAOYSA-N 235411 US9359338, Exe. 021 Serine/threonine-protein kinase B-raf Homo sapiens 24.7 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235411&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233957 340095074 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410277 Fc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C23H17ClF4N4O3/c24-17-5-3-13(9-16(17)23(26,27)28)30-22(34)31-14-4-6-19(18(25)10-14)35-15-7-8-29-20(11-15)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34) ZHKQXCXYBWZCJF-UHFFFAOYSA-N 235412 US9359338, Exe. 022::US9359338, Exe. 027 Serine/threonine-protein kinase B-raf Homo sapiens 3.6 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235412&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233913 340095075 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410278 Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F InChI=1S/C24H20ClF3N4O3/c1-13-10-16(35-17-8-9-29-21(12-17)32-22(33)14-2-3-14)5-7-20(13)31-23(34)30-15-4-6-19(25)18(11-15)24(26,27)28/h4-12,14H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34) SLLLZAODUMTCIH-UHFFFAOYSA-N 235413 US9359338, Exe. 023 Serine/threonine-protein kinase B-raf Homo sapiens 15 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235413&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233784 340095076 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410279 Fc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cc(Oc2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C23H17ClF4N4O3/c24-19-4-3-14(10-18(19)23(26,27)28)30-22(34)31-15-7-13(25)8-17(9-15)35-16-5-6-29-20(11-16)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34) DGRSBVYLOQLHCF-UHFFFAOYSA-N 235414 US9359338, Exe. 024 Serine/threonine-protein kinase B-raf Homo sapiens 5.1 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235414&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118231336 340095077 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410280 Fc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cnc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C22H16ClF4N5O3/c23-16-4-3-12(7-15(16)22(25,26)27)30-21(34)31-13-8-17(24)20(29-10-13)35-14-5-6-28-18(9-14)32-19(33)11-1-2-11/h3-11H,1-2H2,(H,28,32,33)(H2,30,31,34) SILQMMMQYPKYGU-UHFFFAOYSA-N 235415 US9359338, Exe. 025 Serine/threonine-protein kinase B-raf Homo sapiens 9.1 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235415&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233881 340095078 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410281 CC1(CC1)C(=O)Nc1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2F)ccn1 InChI=1S/C24H19ClF4N4O3/c1-23(7-8-23)21(34)33-20-12-15(6-9-30-20)36-19-5-3-14(11-18(19)26)32-22(35)31-13-2-4-17(25)16(10-13)24(27,28)29/h2-6,9-12H,7-8H2,1H3,(H,30,33,34)(H2,31,32,35) ZDWVEWBBYMWVIZ-UHFFFAOYSA-N 235418 US9359338, Exe. 028 Serine/threonine-protein kinase B-raf Homo sapiens 21 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235418&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233965 340095080 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410282 Fc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F InChI=1S/C23H17ClF4N4O3/c24-17-5-3-13(9-16(17)23(26,27)28)30-22(34)31-19-6-4-14(10-18(19)25)35-15-7-8-29-20(11-15)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34) HUJRSGGBAXUNTD-UHFFFAOYSA-N 235419 US9359338, Exe. 029 Serine/threonine-protein kinase B-raf Homo sapiens 7.3 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235419&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233911 340095081 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410283 Cc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F InChI=1S/C24H20ClF3N4O3/c1-13-2-6-16(35-17-8-9-29-21(12-17)32-22(33)14-3-4-14)11-20(13)31-23(34)30-15-5-7-19(25)18(10-15)24(26,27)28/h2,5-12,14H,3-4H2,1H3,(H,29,32,33)(H2,30,31,34) PGLFODISHUVFOO-UHFFFAOYSA-N 235420 US9359338, Exe. 030 Serine/threonine-protein kinase B-raf Homo sapiens 18 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235420&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118231337 340095082 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410284 Cc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C24H20ClF3N4O3/c1-13-10-15(30-23(34)31-16-4-6-19(25)18(11-16)24(26,27)28)5-7-20(13)35-17-8-9-29-21(12-17)32-22(33)14-2-3-14/h4-12,14H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34) CSVJUWNAVHSNSI-UHFFFAOYSA-N 235421 US9359338, Exe. 031 Serine/threonine-protein kinase B-raf Homo sapiens 25 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235421&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233880 340095083 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410285 Fc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cccc(OC(F)(F)F)c1 InChI=1S/C23H18F4N4O4/c24-18-11-15(34-16-8-9-28-20(12-16)31-21(32)13-4-5-13)6-7-19(18)30-22(33)29-14-2-1-3-17(10-14)35-23(25,26)27/h1-3,6-13H,4-5H2,(H,28,31,32)(H2,29,30,33) FFRGRENUQPZOSO-UHFFFAOYSA-N 235424 US9359338, Exe. 034 Serine/threonine-protein kinase B-raf Homo sapiens 9.4 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235424&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233838 340095086 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410286 CC(F)(F)c1cc(F)cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)c1 InChI=1S/C24H20F4N4O3/c1-24(27,28)14-8-15(25)10-16(9-14)30-23(34)31-20-5-4-17(11-19(20)26)35-18-6-7-29-21(12-18)32-22(33)13-2-3-13/h4-13H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34) GPCLSBWLIVAILX-UHFFFAOYSA-N 235425 US9359338, Exe. 035 Serine/threonine-protein kinase B-raf Homo sapiens 8.9 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235425&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233788 340095087 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410287 CS(=O)(=O)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F InChI=1S/C24H20F4N4O5S/c1-38(35,36)18-9-14(24(26,27)28)8-16(10-18)31-23(34)30-15-4-5-20(19(25)11-15)37-17-6-7-29-21(12-17)32-22(33)13-2-3-13/h4-13H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34) IETSOOJAROKDKW-UHFFFAOYSA-N 235427 US9359338, Exe. 037 Serine/threonine-protein kinase B-raf Homo sapiens 26 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235427&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234004 340095089 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410288 CN1CCC(C1)Oc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F InChI=1S/C28H27F4N5O4/c1-37-9-7-21(15-37)40-22-11-17(28(30,31)32)10-19(12-22)35-27(39)34-18-4-5-24(23(29)13-18)41-20-6-8-33-25(14-20)36-26(38)16-2-3-16/h4-6,8,10-14,16,21H,2-3,7,9,15H2,1H3,(H,33,36,38)(H2,34,35,39) WGVUHCVNCPVFAO-UHFFFAOYSA-N 235428 US9359338, Exe. 038 Serine/threonine-protein kinase B-raf Homo sapiens 5.3 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235428&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234011 340095090 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410289 CC1CN(C(=O)O1)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F InChI=1S/C27H23F4N5O5/c1-14-13-36(26(39)40-14)19-9-16(27(29,30)31)8-18(10-19)34-25(38)33-17-4-5-22(21(28)11-17)41-20-6-7-32-23(12-20)35-24(37)15-2-3-15/h4-12,14-15H,2-3,13H2,1H3,(H,32,35,37)(H2,33,34,38) RMDFMOXKNINXOM-UHFFFAOYSA-N 235431 US9359338, Exe. 041 Serine/threonine-protein kinase B-raf Homo sapiens 37.5 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235431&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233836 340095093 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410290 CC(=O)Nc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F InChI=1S/C25H21F4N5O4/c1-13(35)31-17-8-15(25(27,28)29)9-18(10-17)33-24(37)32-16-4-5-21(20(26)11-16)38-19-6-7-30-22(12-19)34-23(36)14-2-3-14/h4-12,14H,2-3H2,1H3,(H,31,35)(H,30,34,36)(H2,32,33,37) LGZIXEVNBUGLPI-UHFFFAOYSA-N 235434 US9359338, Exe. 044 Serine/threonine-protein kinase B-raf Homo sapiens 13 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235434&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233884 340095096 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410291 CC1CN(CC(C)O1)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F InChI=1S/C29H29F4N5O4/c1-16-14-38(15-17(2)41-16)22-10-19(29(31,32)33)9-21(11-22)36-28(40)35-20-5-6-25(24(30)12-20)42-23-7-8-34-26(13-23)37-27(39)18-3-4-18/h5-13,16-18H,3-4,14-15H2,1-2H3,(H,34,37,39)(H2,35,36,40) YPZXUAHYYGAQGH-UHFFFAOYSA-N 235437 US9359338, Exe. 047 Serine/threonine-protein kinase B-raf Homo sapiens 73.6 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235437&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233885 340095099 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410292 CN(C)C1CCN(C1)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F InChI=1S/C29H30F4N6O3/c1-38(2)21-8-10-39(16-21)22-12-18(29(31,32)33)11-20(13-22)36-28(41)35-19-5-6-25(24(30)14-19)42-23-7-9-34-26(15-23)37-27(40)17-3-4-17/h5-7,9,11-15,17,21H,3-4,8,10,16H2,1-2H3,(H,34,37,40)(H2,35,36,41) JPKYSAGLJGHLBE-UHFFFAOYSA-N 235438 US9359338, Exe. 048 Serine/threonine-protein kinase B-raf Homo sapiens 11 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235438&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233918 340095100 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410293 OC1CCN(CC1)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F InChI=1S/C28H27F4N5O4/c29-23-14-18(3-4-24(23)41-22-5-8-33-25(15-22)36-26(39)16-1-2-16)34-27(40)35-19-11-17(28(30,31)32)12-20(13-19)37-9-6-21(38)7-10-37/h3-5,8,11-16,21,38H,1-2,6-7,9-10H2,(H,33,36,39)(H2,34,35,40) KDRVYRSRGFXYOO-UHFFFAOYSA-N 235441 US9359338, Exe. 051 Serine/threonine-protein kinase B-raf Homo sapiens 23.6 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235441&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233791 340095103 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410294 Fc1cc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)N2CCCC2=O)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C27H23F4N5O4/c28-21-13-17(5-6-22(21)40-20-7-8-32-23(14-20)35-25(38)15-3-4-15)33-26(39)34-18-10-16(27(29,30)31)11-19(12-18)36-9-1-2-24(36)37/h5-8,10-15H,1-4,9H2,(H,32,35,38)(H2,33,34,39) JFYUBWFIZUZXMV-UHFFFAOYSA-N 235442 US9359338, Exe. 052 Serine/threonine-protein kinase B-raf Homo sapiens 13 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235442&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233969 340095104 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410295 CC(F)(F)c1cncc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c1 InChI=1S/C23H20F3N5O3/c1-23(25,26)14-8-16(12-27-11-14)30-22(33)29-15-4-5-19(18(24)9-15)34-17-6-7-28-20(10-17)31-21(32)13-2-3-13/h4-13H,2-3H2,1H3,(H,28,31,32)(H2,29,30,33) OQJZBWFPSBLNRC-UHFFFAOYSA-N 235446 US9359338, Exe. 056 Serine/threonine-protein kinase B-raf Homo sapiens 65 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235446&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233966 340095108 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410296 Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)C1CC1 InChI=1S/C25H22F2N4O3/c26-19-7-5-16(14-1-2-14)11-21(19)30-25(33)29-17-6-8-22(20(27)12-17)34-18-9-10-28-23(13-18)31-24(32)15-3-4-15/h5-15H,1-4H2,(H,28,31,32)(H2,29,30,33) CUWALEUMEYIAPG-UHFFFAOYSA-N 235448 US9359338, Exe. 058 Serine/threonine-protein kinase B-raf Homo sapiens 116 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235448&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233839 340095110 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410297 Fc1c[nH]c2ccc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)cc12 InChI=1S/C24H19F2N5O3/c25-18-10-15(30-24(33)29-14-3-5-20-17(9-14)19(26)12-28-20)4-6-21(18)34-16-7-8-27-22(11-16)31-23(32)13-1-2-13/h3-13,28H,1-2H2,(H,27,31,32)(H2,29,30,33) XYTFGVXDSQVGBZ-UHFFFAOYSA-N 235449 US9359338, Exe. 059 Serine/threonine-protein kinase B-raf Homo sapiens 90 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235449&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233970 340095111 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410298 Fc1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C23H18F4N4O3/c24-18-11-16(30-22(33)29-15-3-1-2-14(10-15)23(25,26)27)6-7-19(18)34-17-8-9-28-20(12-17)31-21(32)13-4-5-13/h1-3,6-13H,4-5H2,(H,28,31,32)(H2,29,30,33) BPCWWXWVIUQJOJ-UHFFFAOYSA-N 235451 US9359338, Exe. 061 Serine/threonine-protein kinase B-raf Homo sapiens 6.3 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235451&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233919 340095113 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410299 Fc1cc(NC(=O)Nc2ccc(C#N)c(c2)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C24H17F4N5O3/c25-19-10-16(32-23(35)31-15-4-3-14(12-29)18(9-15)24(26,27)28)5-6-20(19)36-17-7-8-30-21(11-17)33-22(34)13-1-2-13/h3-11,13H,1-2H2,(H,30,33,34)(H2,31,32,35) YSIDYNUWOMCGCH-UHFFFAOYSA-N 235452 US9359338, Exe. 062 Serine/threonine-protein kinase B-raf Homo sapiens 7 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235452&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233794 340095114 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410300 Fc1cc(NC(=O)Nc2ccc(Cl)c(OC(F)(F)F)c2)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C23H17ClF4N4O4/c24-16-5-3-14(10-19(16)36-23(26,27)28)31-22(34)30-13-4-6-18(17(25)9-13)35-15-7-8-29-20(11-15)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34) WLRIPCABMAVKCW-UHFFFAOYSA-N 235453 US9359338, Exe. 063 Serine/threonine-protein kinase B-raf Homo sapiens 14.9 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235453&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233494 340095115 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410301 CN1CCN(Cc2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3)cc(c2)C(F)(F)F)CC1 InChI=1S/C29H31F3N6O3/c1-37-10-12-38(13-11-37)18-19-14-21(29(30,31)32)16-23(15-19)35-28(40)34-22-4-6-24(7-5-22)41-25-8-9-33-26(17-25)36-27(39)20-2-3-20/h4-9,14-17,20H,2-3,10-13,18H2,1H3,(H,33,36,39)(H2,34,35,40) VMDPIUWBKSTZID-UHFFFAOYSA-N 235454 US9359338, Exe. 064 Serine/threonine-protein kinase B-raf Homo sapiens 4.6 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235454&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233972 340095116 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410302 CC(F)(F)c1cncc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)c1 InChI=1S/C23H21F2N5O3/c1-23(24,25)15-10-17(13-26-12-15)29-22(32)28-16-4-6-18(7-5-16)33-19-8-9-27-20(11-19)30-21(31)14-2-3-14/h4-14H,2-3H2,1H3,(H,27,30,31)(H2,28,29,32) KFKKAFWDFOBUQJ-UHFFFAOYSA-N 235455 US9359338, Exe. 065 Serine/threonine-protein kinase B-raf Homo sapiens 25 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235455&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233886 340095117 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410303 Cc1cc(Oc2cc(NC(=O)C3CC3)ncn2)ccc1NC(=O)Nc1ccc(F)c(c1)C(F)(F)F InChI=1S/C23H19F4N5O3/c1-12-8-15(35-20-10-19(28-11-29-20)32-21(33)13-2-3-13)5-7-18(12)31-22(34)30-14-4-6-17(24)16(9-14)23(25,26)27/h4-11,13H,2-3H2,1H3,(H2,30,31,34)(H,28,29,32,33) YWADFMAXJQIFHP-UHFFFAOYSA-N 235460 US9359338, Exe. 070 Serine/threonine-protein kinase B-raf Homo sapiens 145 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235460&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 72945587 340095122 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410304 Cc1cc(Oc2cc(NC(=O)C3CC3)ncn2)ccc1NC(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C23H20F3N5O3/c1-13-9-17(34-20-11-19(27-12-28-20)31-21(32)14-5-6-14)7-8-18(13)30-22(33)29-16-4-2-3-15(10-16)23(24,25)26/h2-4,7-12,14H,5-6H2,1H3,(H2,29,30,33)(H,27,28,31,32) VUHUIMGDVJTWMZ-UHFFFAOYSA-N 235464 US9359338, Exe. 074 Serine/threonine-protein kinase B-raf Homo sapiens 146 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235464&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 72945769 340095126 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410305 Cc1cc(Oc2cc(NC(=O)C3CC3)ncn2)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(C)(F)F InChI=1S/C24H22ClF2N5O3/c1-13-9-16(35-21-11-20(28-12-29-21)32-22(33)14-3-4-14)6-8-19(13)31-23(34)30-15-5-7-18(25)17(10-15)24(2,26)27/h5-12,14H,3-4H2,1-2H3,(H2,30,31,34)(H,28,29,32,33) PPZGVHXCWUFSES-UHFFFAOYSA-N 235475 US9359338, Exe. 085 Serine/threonine-protein kinase B-raf Homo sapiens 45 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235475&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233896 340095137 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410306 CC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3cc(NC(=O)C4CC4)ncn3)c(F)c2)ccc1Cl InChI=1S/C23H19ClF3N5O3/c1-23(26,27)15-8-13(4-6-16(15)24)30-22(34)31-14-5-7-18(17(25)9-14)35-20-10-19(28-11-29-20)32-21(33)12-2-3-12/h4-12H,2-3H2,1H3,(H2,30,31,34)(H,28,29,32,33) FGTIIEVHDSVXQZ-UHFFFAOYSA-N 235495 US9359338, Exe. 105 Serine/threonine-protein kinase B-raf Homo sapiens 153 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235495&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233921 340095157 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410307 Fc1ccc(cc1NC(=O)Nc1ccc(Oc2cc(NC(=O)C3CC3)ncn2)cc1F)C(F)(F)F InChI=1S/C22H16F5N5O3/c23-14-5-3-12(22(25,26)27)7-17(14)31-21(34)30-16-6-4-13(8-15(16)24)35-19-9-18(28-10-29-19)32-20(33)11-1-2-11/h3-11H,1-2H2,(H2,30,31,34)(H,28,29,32,33) QUZXQYOKNVMOLF-UHFFFAOYSA-N 235497 US9359338, Exe. 107 Serine/threonine-protein kinase B-raf Homo sapiens 31 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235497&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233796 340095159 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410308 Fc1cc(Oc2cc(NC(=O)C3CC3)ncn2)ccc1NC(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C22H17F4N5O3/c23-16-9-15(34-19-10-18(27-11-28-19)31-20(32)12-4-5-12)6-7-17(16)30-21(33)29-14-3-1-2-13(8-14)22(24,25)26/h1-3,6-12H,4-5H2,(H2,29,30,33)(H,27,28,31,32) GLWAISIRFQVHLA-UHFFFAOYSA-N 235498 US9359338, Exe. 108 Serine/threonine-protein kinase B-raf Homo sapiens 41 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235498&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233899 340095160 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410309 CC(F)(F)c1ccc(F)c(NC(=O)Nc2ccc(Oc3cc(NC(=O)C4CC4)ncn3)cc2F)c1 InChI=1S/C23H19F4N5O3/c1-23(26,27)13-4-6-15(24)18(8-13)31-22(34)30-17-7-5-14(9-16(17)25)35-20-10-19(28-11-29-20)32-21(33)12-2-3-12/h4-12H,2-3H2,1H3,(H2,30,31,34)(H,28,29,32,33) RUGFDAFGDGVRQI-UHFFFAOYSA-N 235499 US9359338, Exe. 109 Serine/threonine-protein kinase B-raf Homo sapiens 32 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235499&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234018 340095161 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410310 CC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3cc(NC(=O)C4CC4)ncn3)cc2F)ccc1Cl InChI=1S/C23H19ClF3N5O3/c1-23(26,27)15-8-13(4-6-16(15)24)30-22(34)31-18-7-5-14(9-17(18)25)35-20-10-19(28-11-29-20)32-21(33)12-2-3-12/h4-12H,2-3H2,1H3,(H2,30,31,34)(H,28,29,32,33) MXSVQWYXYFLIGH-UHFFFAOYSA-N 235500 US9359338, Exe. 110 Serine/threonine-protein kinase B-raf Homo sapiens 24 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235500&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233837 340095162 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410311 Cc1cc(NC(=O)Nc2cc(ccc2F)C(C)(F)F)ccc1Oc1cc(NC(=O)C2CC2)ncn1 InChI=1S/C24H22F3N5O3/c1-13-9-16(30-23(34)31-18-10-15(24(2,26)27)5-7-17(18)25)6-8-19(13)35-21-11-20(28-12-29-21)32-22(33)14-3-4-14/h5-12,14H,3-4H2,1-2H3,(H2,30,31,34)(H,28,29,32,33) JBWLAJFACDKALA-UHFFFAOYSA-N 235506 US9359338, Exe. 116 Serine/threonine-protein kinase B-raf Homo sapiens 111 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235506&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233798 340095168 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410312 Cc1cc(NC(=O)Nc2ccc(F)c(c2)C(C)(F)F)ccc1Oc1cc(NC(=O)C2CC2)ncn1 InChI=1S/C24H22F3N5O3/c1-13-9-15(30-23(34)31-16-5-7-18(25)17(10-16)24(2,26)27)6-8-19(13)35-21-11-20(28-12-29-21)32-22(33)14-3-4-14/h5-12,14H,3-4H2,1-2H3,(H2,30,31,34)(H,28,29,32,33) ZMABKJDXSRFNMC-UHFFFAOYSA-N 235508 US9359338, Exe. 118 Serine/threonine-protein kinase B-raf Homo sapiens 293 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235508&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233843 340095170 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410313 Cc1cc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cnc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C23H19F4N5O3/c1-12-8-15(30-22(34)31-18-9-14(23(25,26)27)4-5-17(18)24)11-29-21(12)35-16-6-7-28-19(10-16)32-20(33)13-2-3-13/h4-11,13H,2-3H2,1H3,(H,28,32,33)(H2,30,31,34) LNTLFPJKIYSVOZ-UHFFFAOYSA-N 235514 US9359338, Exe. 124 Serine/threonine-protein kinase B-raf Homo sapiens 10.4 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235514&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233849 340095176 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410314 COc1ccc(NC(=O)Nc2cnc(Oc3ccnc(NC(=O)C4CC4)c3)c(C)c2)cc1C(F)(F)F InChI=1S/C24H22F3N5O4/c1-13-9-16(31-23(34)30-15-5-6-19(35-2)18(10-15)24(25,26)27)12-29-22(13)36-17-7-8-28-20(11-17)32-21(33)14-3-4-14/h5-12,14H,3-4H2,1-2H3,(H,28,32,33)(H2,30,31,34) YQWKSFHULJHPKO-UHFFFAOYSA-N 235515 US9359338, Exe. 125 Serine/threonine-protein kinase B-raf Homo sapiens 8.6 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235515&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234017 340095177 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410315 CC(C)Oc1cc(NC(=O)Nc2cnc(Oc3ccnc(NC(=O)C4CC4)c3)c(C)c2)cc(c1)C(F)(F)F InChI=1S/C26H26F3N5O4/c1-14(2)37-21-10-17(26(27,28)29)9-18(11-21)32-25(36)33-19-8-15(3)24(31-13-19)38-20-6-7-30-22(12-20)34-23(35)16-4-5-16/h6-14,16H,4-5H2,1-3H3,(H,30,34,35)(H2,32,33,36) WHCYNEVUNVSFSN-UHFFFAOYSA-N 235516 US9359338, Exe. 126 Serine/threonine-protein kinase B-raf Homo sapiens 61.4 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235516&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233928 340095178 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410316 Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ncc1NC(=O)Nc1cc(ccc1F)C(F)(F)F InChI=1S/C23H19F4N5O3/c1-12-8-20(35-15-6-7-28-19(10-15)32-21(33)13-2-3-13)29-11-18(12)31-22(34)30-17-9-14(23(25,26)27)4-5-16(17)24/h4-11,13H,2-3H2,1H3,(H,28,32,33)(H2,30,31,34) UZSRDXFBZCKHKI-UHFFFAOYSA-N 235517 US9359338, Exe. 127 Serine/threonine-protein kinase B-raf Homo sapiens 7.2 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235517&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233846 340095179 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410317 Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ncc1NC(=O)Nc1cc(ccc1F)C(C)(F)F InChI=1S/C24H22F3N5O3/c1-13-9-21(35-16-7-8-28-20(11-16)32-22(33)14-3-4-14)29-12-19(13)31-23(34)30-18-10-15(24(2,26)27)5-6-17(18)25/h5-12,14H,3-4H2,1-2H3,(H,28,32,33)(H2,30,31,34) LWTJZNSUKOTVRV-UHFFFAOYSA-N 235518 US9359338, Exe. 128 Serine/threonine-protein kinase B-raf Homo sapiens 6.2 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235518&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233795 340095180 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410318 CS(=O)(=O)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)nc2)cc(c1)C(F)(F)F InChI=1S/C23H20F3N5O5S/c1-37(34,35)18-9-14(23(24,25)26)8-16(10-18)30-22(33)29-15-4-5-20(28-12-15)36-17-6-7-27-19(11-17)31-21(32)13-2-3-13/h4-13H,2-3H2,1H3,(H,27,31,32)(H2,29,30,33) OFZXVZSRHPGDON-UHFFFAOYSA-N 235520 US9359338, Exe. 130 Serine/threonine-protein kinase B-raf Homo sapiens 29.7 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235520&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233980 340095182 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410319 CN1CCC(CC1)Nc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)nc2)cc(c1)C(F)(F)F InChI=1S/C28H30F3N7O3/c1-38-10-7-19(8-11-38)34-21-12-18(28(29,30)31)13-22(14-21)36-27(40)35-20-4-5-25(33-16-20)41-23-6-9-32-24(15-23)37-26(39)17-2-3-17/h4-6,9,12-17,19,34H,2-3,7-8,10-11H2,1H3,(H,32,37,39)(H2,35,36,40) ZDUYBXCDPILNJU-UHFFFAOYSA-N 235521 US9359338, Exe. 131 Serine/threonine-protein kinase B-raf Homo sapiens 12.5 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235521&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233985 340095183 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410320 FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)nc2)cc(c1)N1CCS(=O)(=O)CC1 InChI=1S/C26H25F3N6O5S/c27-26(28,29)17-11-19(13-20(12-17)35-7-9-41(38,39)10-8-35)33-25(37)32-18-3-4-23(31-15-18)40-21-5-6-30-22(14-21)34-24(36)16-1-2-16/h3-6,11-16H,1-2,7-10H2,(H,30,34,36)(H2,32,33,37) ZGFGGOXPGJYLDU-UHFFFAOYSA-N 235522 US9359338, Exe. 132 Serine/threonine-protein kinase B-raf Homo sapiens 39 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235522&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233844 340095184 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410321 FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cn2)ccc1C#N InChI=1S/C23H17F3N6O3/c24-23(25,26)18-9-15(4-3-14(18)11-27)30-22(34)32-19-6-5-17(12-29-19)35-16-7-8-28-20(10-16)31-21(33)13-1-2-13/h3-10,12-13H,1-2H2,(H,28,31,33)(H2,29,30,32,34) SGWAIEWMTQWUJP-UHFFFAOYSA-N 235523 US9359338, Exe. 133 Serine/threonine-protein kinase B-raf Homo sapiens 25 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235523&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233799 340095185 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410322 CS(=O)(=O)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cn2)cc(c1)C(F)(F)F InChI=1S/C23H20F3N5O5S/c1-37(34,35)18-9-14(23(24,25)26)8-15(10-18)29-22(33)31-19-5-4-17(12-28-19)36-16-6-7-27-20(11-16)30-21(32)13-2-3-13/h4-13H,2-3H2,1H3,(H,27,30,32)(H2,28,29,31,33) YKSOFUBFGNIVRO-UHFFFAOYSA-N 235526 US9359338, Exe. 136 Serine/threonine-protein kinase B-raf Homo sapiens 29 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235526&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233797 340095188 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410323 FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)ccc1Cl InChI=1S/C23H18ClF3N4O3/c24-19-8-5-15(11-18(19)23(25,26)27)30-22(33)29-14-3-6-16(7-4-14)34-17-9-10-28-20(12-17)31-21(32)13-1-2-13/h3-13H,1-2H2,(H,28,31,32)(H2,29,30,33) PULXDQFSRXRBQQ-UHFFFAOYSA-N 235527 US9359338, Exe. 137 Serine/threonine-protein kinase B-raf Homo sapiens 11.3 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235527&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233930 340095189 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410324 Fc1ccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)cc1C(F)(F)F InChI=1S/C23H18F4N4O3/c24-19-8-5-15(11-18(19)23(25,26)27)30-22(33)29-14-3-6-16(7-4-14)34-17-9-10-28-20(12-17)31-21(32)13-1-2-13/h3-13H,1-2H2,(H,28,31,32)(H2,29,30,33) JPDKXKDXMZBWEF-UHFFFAOYSA-N 235528 US9359338, Exe. 138 Serine/threonine-protein kinase B-raf Homo sapiens 26 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235528&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234023 340095190 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410325 FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)ccc1C#N InChI=1S/C24H18F3N5O3/c25-24(26,27)20-11-17(4-3-15(20)13-28)31-23(34)30-16-5-7-18(8-6-16)35-19-9-10-29-21(12-19)32-22(33)14-1-2-14/h3-12,14H,1-2H2,(H,29,32,33)(H2,30,31,34) SVMJLSDURUIKEY-UHFFFAOYSA-N 235529 US9359338, Exe. 139 Serine/threonine-protein kinase B-raf Homo sapiens 13 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235529&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233847 340095191 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410326 Fc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)cc(c1)C(F)(F)F InChI=1S/C23H18F4N4O3/c24-15-9-14(23(25,26)27)10-17(11-15)30-22(33)29-16-3-5-18(6-4-16)34-19-7-8-28-20(12-19)31-21(32)13-1-2-13/h3-13H,1-2H2,(H,28,31,32)(H2,29,30,33) MBQWLHAWLFCPBZ-UHFFFAOYSA-N 235531 US9359338, Exe. 141 Serine/threonine-protein kinase B-raf Homo sapiens 125 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235531&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233986 340095193 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410327 FC(F)(F)c1ccc(Cl)c(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)c1 InChI=1S/C23H18ClF3N4O3/c24-18-8-3-14(23(25,26)27)11-19(18)30-22(33)29-15-4-6-16(7-5-15)34-17-9-10-28-20(12-17)31-21(32)13-1-2-13/h3-13H,1-2H2,(H,28,31,32)(H2,29,30,33) HXOLNQUWFVHPAT-UHFFFAOYSA-N 235532 US9359338, Exe. 142 Serine/threonine-protein kinase B-raf Homo sapiens 39 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235532&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233901 340095194 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410328 CN1CCC(CC1)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)cc(c1)C(F)(F)F InChI=1S/C29H30F3N5O3/c1-37-12-9-18(10-13-37)20-14-21(29(30,31)32)16-23(15-20)35-28(39)34-22-4-6-24(7-5-22)40-25-8-11-33-26(17-25)36-27(38)19-2-3-19/h4-8,11,14-19H,2-3,9-10,12-13H2,1H3,(H,33,36,38)(H2,34,35,39) KCKRCSUCMZGMIL-UHFFFAOYSA-N 235533 US9359338, Exe. 143 Serine/threonine-protein kinase B-raf Homo sapiens 5.5 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235533&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234025 340095195 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410329 FC(F)(F)c1cccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)c1 InChI=1S/C23H19F3N4O3/c24-23(25,26)15-2-1-3-17(12-15)29-22(32)28-16-6-8-18(9-7-16)33-19-10-11-27-20(13-19)30-21(31)14-4-5-14/h1-3,6-14H,4-5H2,(H,27,30,31)(H2,28,29,32) KIIDDYRUSRTQAQ-UHFFFAOYSA-N 235534 US9359338, Exe. 144 Serine/threonine-protein kinase B-raf Homo sapiens 30 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235534&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233850 340095196 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410330 CS(=O)(=O)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)cc(c1)C(F)(F)F InChI=1S/C24H21F3N4O5S/c1-37(34,35)20-11-15(24(25,26)27)10-17(12-20)30-23(33)29-16-4-6-18(7-5-16)36-19-8-9-28-21(13-19)31-22(32)14-2-3-14/h4-14H,2-3H2,1H3,(H,28,31,32)(H2,29,30,33) ALVYZBFXDIJQLR-UHFFFAOYSA-N 235535 US9359338, Exe. 145 Serine/threonine-protein kinase B-raf Homo sapiens 5.1 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235535&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233851 340095197 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410331 FC(F)(F)Oc1cccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)c1 InChI=1S/C23H19F3N4O4/c24-23(25,26)34-19-3-1-2-16(12-19)29-22(32)28-15-6-8-17(9-7-15)33-18-10-11-27-20(13-18)30-21(31)14-4-5-14/h1-3,6-14H,4-5H2,(H,27,30,31)(H2,28,29,32) WWJACNFNSNFPFJ-UHFFFAOYSA-N 235536 US9359338, Exe. 146 Serine/threonine-protein kinase B-raf Homo sapiens 14 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235536&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233857 340095198 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410332 CC(F)(F)c1ccnc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)c1 InChI=1S/C23H21F2N5O3/c1-23(24,25)15-8-10-26-19(12-15)30-22(32)28-16-4-6-17(7-5-16)33-18-9-11-27-20(13-18)29-21(31)14-2-3-14/h4-14H,2-3H2,1H3,(H,27,29,31)(H2,26,28,30,32) AQYOQSLGTSHULO-UHFFFAOYSA-N 235537 US9359338, Exe. 147 Serine/threonine-protein kinase B-raf Homo sapiens 15 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235537&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233801 340095199 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410333 CC(F)(F)c1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)c1 InChI=1S/C24H21F3N4O3/c1-24(26,27)15-4-9-19(25)20(12-15)30-23(33)29-16-5-7-17(8-6-16)34-18-10-11-28-21(13-18)31-22(32)14-2-3-14/h4-14H,2-3H2,1H3,(H,28,31,32)(H2,29,30,33) MEYILBGKENVRGC-UHFFFAOYSA-N 235538 US9359338, Exe. 148 Serine/threonine-protein kinase B-raf Homo sapiens 16 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235538&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233988 340095200 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410334 CC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)ccc1Cl InChI=1S/C24H21ClF2N4O3/c1-24(26,27)19-12-16(6-9-20(19)25)30-23(33)29-15-4-7-17(8-5-15)34-18-10-11-28-21(13-18)31-22(32)14-2-3-14/h4-14H,2-3H2,1H3,(H,28,31,32)(H2,29,30,33) YNRDEUFQOSIAMC-UHFFFAOYSA-N 235539 US9359338, Exe. 149 Serine/threonine-protein kinase B-raf Homo sapiens 38 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235539&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233990 340095201 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410335 FC1(F)CCOc2ccc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3)cc12 InChI=1S/C25H22F2N4O4/c26-25(27)10-12-34-21-8-5-17(13-20(21)25)30-24(33)29-16-3-6-18(7-4-16)35-19-9-11-28-22(14-19)31-23(32)15-1-2-15/h3-9,11,13-15H,1-2,10,12H2,(H,28,31,32)(H2,29,30,33) BJCCMNRETBMKRO-UHFFFAOYSA-N 235541 US9359338, Exe. 151 Serine/threonine-protein kinase B-raf Homo sapiens 3.3 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235541&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233981 340095203 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410336 FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)cc(c1)C#N InChI=1S/C24H18F3N5O3/c25-24(26,27)16-9-14(13-28)10-18(11-16)31-23(34)30-17-3-5-19(6-4-17)35-20-7-8-29-21(12-20)32-22(33)15-1-2-15/h3-12,15H,1-2H2,(H,29,32,33)(H2,30,31,34) NMHPFEBNFJYDBV-UHFFFAOYSA-N 235542 US9359338, Exe. 152 Serine/threonine-protein kinase B-raf Homo sapiens 72 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235542&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233989 340095204 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410337 Fc1ccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc1C(F)(F)F InChI=1S/C23H17F5N4O3/c24-17-5-3-13(9-16(17)23(26,27)28)30-22(34)31-14-4-6-19(18(25)10-14)35-15-7-8-29-20(11-15)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34) AFHFZUPLWVRDMP-UHFFFAOYSA-N 235543 US9359338, Exe. 153 Serine/threonine-protein kinase B-raf Homo sapiens 32 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235543&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233906 340095205 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410338 Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)C(F)(F)F InChI=1S/C23H17F5N4O3/c24-16-5-3-13(23(26,27)28)9-18(16)31-22(34)30-14-4-6-19(17(25)10-14)35-15-7-8-29-20(11-15)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34) YUEXOEVVUSJCCS-UHFFFAOYSA-N 235546 US9359338, Exe. 156 Serine/threonine-protein kinase B-raf Homo sapiens 37 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235546&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233984 340095208 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410339 Fc1cc(NC(=O)Nc2cc(ccc2Cl)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C23H17ClF4N4O3/c24-16-5-3-13(23(26,27)28)9-18(16)31-22(34)30-14-4-6-19(17(25)10-14)35-15-7-8-29-20(11-15)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34) MUUBZCZSPQCDFI-UHFFFAOYSA-N 235547 US9359338, Exe. 157 Serine/threonine-protein kinase B-raf Homo sapiens 43 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235547&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233992 340095209 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410340 Fc1cc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)-c2ccncc2)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C28H21F4N5O3/c29-23-14-20(3-4-24(23)40-22-7-10-34-25(15-22)37-26(38)17-1-2-17)35-27(39)36-21-12-18(16-5-8-33-9-6-16)11-19(13-21)28(30,31)32/h3-15,17H,1-2H2,(H,34,37,38)(H2,35,36,39) SZUKWCISGROJRA-UHFFFAOYSA-N 235549 US9359338, Exe. 159 Serine/threonine-protein kinase B-raf Homo sapiens 35.4 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235549&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233993 340095211 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410341 CN1CCC(CC1)Nc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F InChI=1S/C29H30F4N6O3/c1-39-10-7-19(8-11-39)35-21-12-18(29(31,32)33)13-22(14-21)37-28(41)36-20-4-5-25(24(30)15-20)42-23-6-9-34-26(16-23)38-27(40)17-2-3-17/h4-6,9,12-17,19,35H,2-3,7-8,10-11H2,1H3,(H,34,38,40)(H2,36,37,41) OCIKWMHJONAJRM-UHFFFAOYSA-N 235551 US9359338, Exe. 161 Serine/threonine-protein kinase B-raf Homo sapiens 7.9 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235551&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233912 340095213 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410342 CC1CN(CCO1)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F InChI=1S/C28H27F4N5O4/c1-16-15-37(8-9-40-16)21-11-18(28(30,31)32)10-20(12-21)35-27(39)34-19-4-5-24(23(29)13-19)41-22-6-7-33-25(14-22)36-26(38)17-2-3-17/h4-7,10-14,16-17H,2-3,8-9,15H2,1H3,(H,33,36,38)(H2,34,35,39) HXTKTWLQDFJSIJ-UHFFFAOYSA-N 235552 US9359338, Exe. 162 Serine/threonine-protein kinase B-raf Homo sapiens 22.5 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235552&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233991 340095214 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410343 Fc1cc(NC(=O)Nc2cc(NC(=O)C=C)cc(c2)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C26H21F4N5O4/c1-2-23(36)32-17-9-15(26(28,29)30)10-18(11-17)34-25(38)33-16-5-6-21(20(27)12-16)39-19-7-8-31-22(13-19)35-24(37)14-3-4-14/h2,5-14H,1,3-4H2,(H,32,36)(H,31,35,37)(H2,33,34,38) KTJRIGZLXIKSGR-UHFFFAOYSA-N 235553 US9359338, Exe. 163 Serine/threonine-protein kinase B-raf Homo sapiens 24 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235553&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233938 340095215 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410344 CN1CCC(CC1)Oc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F InChI=1S/C29H29F4N5O4/c1-38-10-7-21(8-11-38)41-23-13-18(29(31,32)33)12-20(14-23)36-28(40)35-19-4-5-25(24(30)15-19)42-22-6-9-34-26(16-22)37-27(39)17-2-3-17/h4-6,9,12-17,21H,2-3,7-8,10-11H2,1H3,(H,34,37,39)(H2,35,36,40) RWALNINUCKMSQQ-UHFFFAOYSA-N 235554 US9359338, Exe. 164 Serine/threonine-protein kinase B-raf Homo sapiens 71.5 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235554&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233810 340095216 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410345 CS(=O)(=O)Nc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F InChI=1S/C24H21F4N5O5S/c1-39(36,37)33-17-9-14(24(26,27)28)8-16(10-17)31-23(35)30-15-4-5-20(19(25)11-15)38-18-6-7-29-21(12-18)32-22(34)13-2-3-13/h4-13,33H,2-3H2,1H3,(H,29,32,34)(H2,30,31,35) OMRQQSCMAHVMJT-UHFFFAOYSA-N 235555 US9359338, Exe. 165 Serine/threonine-protein kinase B-raf Homo sapiens 6.6 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235555&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233805 340095217 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410346 Fc1cc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)N2CCS(=O)(=O)CC2)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C27H25F4N5O5S/c28-22-14-18(3-4-23(22)41-21-5-6-32-24(15-21)35-25(37)16-1-2-16)33-26(38)34-19-11-17(27(29,30)31)12-20(13-19)36-7-9-42(39,40)10-8-36/h3-6,11-16H,1-2,7-10H2,(H,32,35,37)(H2,33,34,38) YKQIPFPCSZULFR-UHFFFAOYSA-N 235556 US9359338, Exe. 166 Serine/threonine-protein kinase B-raf Homo sapiens 27 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235556&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233994 340095218 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410347 CN1CCN(Cc2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)cc(c2)C(F)(F)F)CC1 InChI=1S/C29H30F4N6O3/c1-38-8-10-39(11-9-38)17-18-12-20(29(31,32)33)14-22(13-18)36-28(41)35-21-4-5-25(24(30)15-21)42-23-6-7-34-26(16-23)37-27(40)19-2-3-19/h4-7,12-16,19H,2-3,8-11,17H2,1H3,(H,34,37,40)(H2,35,36,41) LYBQCYLQVVRONY-UHFFFAOYSA-N 235557 US9359338, Exe. 167 Serine/threonine-protein kinase B-raf Homo sapiens 23.8 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235557&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233806 340095219 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410348 CN1CCC(CC1)Nc1ccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc1C(F)(F)F InChI=1S/C29H30F4N6O3/c1-39-12-9-18(10-13-39)35-24-6-4-19(14-22(24)29(31,32)33)36-28(41)37-20-5-7-25(23(30)15-20)42-21-8-11-34-26(16-21)38-27(40)17-2-3-17/h4-8,11,14-18,35H,2-3,9-10,12-13H2,1H3,(H,34,38,40)(H2,36,37,41) QAJLXACBOOCFOX-UHFFFAOYSA-N 235558 US9359338, Exe. 168 Serine/threonine-protein kinase B-raf Homo sapiens 7.9 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235558&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233852 340095220 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410349 Fc1cc(NC(=O)Nc2cc(ncn2)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C21H16F4N6O3/c22-14-7-12(29-20(33)31-18-9-16(21(23,24)25)27-10-28-18)3-4-15(14)34-13-5-6-26-17(8-13)30-19(32)11-1-2-11/h3-11H,1-2H2,(H,26,30,32)(H2,27,28,29,31,33) FOCSQGCMWCXWHS-UHFFFAOYSA-N 235560 US9359338, Exe. 170 Serine/threonine-protein kinase B-raf Homo sapiens 96 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235560&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234027 340095222 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410350 Fc1cc(NC(=O)Nc2cccc(OC(F)(F)F)c2)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C23H18F4N4O4/c24-18-11-15(30-22(33)29-14-2-1-3-17(10-14)35-23(25,26)27)6-7-19(18)34-16-8-9-28-20(12-16)31-21(32)13-4-5-13/h1-3,6-13H,4-5H2,(H,28,31,32)(H2,29,30,33) UJIFKUWCTKOZIC-UHFFFAOYSA-N 235565 US9359338, Exe. 175 Serine/threonine-protein kinase B-raf Homo sapiens 9.8 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235565&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233904 340095227 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410351 Fc1cc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C23H18F4N4O4/c24-18-11-15(30-22(33)29-14-3-6-16(7-4-14)35-23(25,26)27)5-8-19(18)34-17-9-10-28-20(12-17)31-21(32)13-1-2-13/h3-13H,1-2H2,(H,28,31,32)(H2,29,30,33) DVHXPBCAVUTLGS-UHFFFAOYSA-N 235568 US9359338, Exe. 178 Serine/threonine-protein kinase B-raf Homo sapiens 34.7 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235568&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234020 340095230 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410352 CC(F)(F)c1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c1 InChI=1S/C24H20F4N4O3/c1-24(27,28)14-4-6-17(25)19(10-14)31-23(34)30-15-5-7-20(18(26)11-15)35-16-8-9-29-21(12-16)32-22(33)13-2-3-13/h4-13H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34) MDNLKYRIJOCOMZ-UHFFFAOYSA-N 235571 US9359338, Exe. 181 Serine/threonine-protein kinase B-raf Homo sapiens 4.8 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235571&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233999 340095233 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410353 CC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)ccc1Cl InChI=1S/C24H20ClF3N4O3/c1-24(27,28)17-10-14(4-6-18(17)25)30-23(34)31-15-5-7-20(19(26)11-15)35-16-8-9-29-21(12-16)32-22(33)13-2-3-13/h4-13H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34) SBKGYSBNEKDGLO-UHFFFAOYSA-N 235572 US9359338, Exe. 182 Serine/threonine-protein kinase B-raf Homo sapiens 32 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235572&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234001 340095234 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410354 CC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)ccc1F InChI=1S/C24H20F4N4O3/c1-24(27,28)17-10-14(4-6-18(17)25)30-23(34)31-15-5-7-20(19(26)11-15)35-16-8-9-29-21(12-16)32-22(33)13-2-3-13/h4-13H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34) KRVCCGBAAVWARK-UHFFFAOYSA-N 235573 US9359338, Exe. 183 Serine/threonine-protein kinase B-raf Homo sapiens 56 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235573&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234024 340095235 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410355 Fc1ccc(Cl)cc1NC(=O)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1 InChI=1S/C22H17ClF2N4O3/c23-13-3-5-16(24)18(9-13)28-22(31)27-14-4-6-19(17(25)10-14)32-15-7-8-26-20(11-15)29-21(30)12-1-2-12/h3-12H,1-2H2,(H,26,29,30)(H2,27,28,31) COPGQJZYDLKRLX-UHFFFAOYSA-N 235574 US9359338, Exe. 184 Serine/threonine-protein kinase B-raf Homo sapiens 73.4 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235574&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233942 340095236 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410356 Fc1cc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)-c2cccnc2)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C28H21F4N5O3/c29-23-13-20(5-6-24(23)40-22-7-9-34-25(14-22)37-26(38)16-3-4-16)35-27(39)36-21-11-18(17-2-1-8-33-15-17)10-19(12-21)28(30,31)32/h1-2,5-16H,3-4H2,(H,34,37,38)(H2,35,36,39) PJPBXYITYFKAMG-UHFFFAOYSA-N 235576 US9359338, Exe. 186 Serine/threonine-protein kinase B-raf Homo sapiens 27.5 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235576&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233945 340095238 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410357 CC(C)Nc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F InChI=1S/C26H25F4N5O3/c1-14(2)32-18-9-16(26(28,29)30)10-19(11-18)34-25(37)33-17-5-6-22(21(27)12-17)38-20-7-8-31-23(13-20)35-24(36)15-3-4-15/h5-15,32H,3-4H2,1-2H3,(H,31,35,36)(H2,33,34,37) WSJRJUWHVORBLK-UHFFFAOYSA-N 235577 US9359338, Exe. 187 Serine/threonine-protein kinase B-raf Homo sapiens 34.3 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235577&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234002 340095239 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410358 CN1CCC(CC1)Oc1ccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc1C(F)(F)F InChI=1S/C29H29F4N5O4/c1-38-12-9-20(10-13-38)41-24-6-4-18(14-22(24)29(31,32)33)35-28(40)36-19-5-7-25(23(30)15-19)42-21-8-11-34-26(16-21)37-27(39)17-2-3-17/h4-8,11,14-17,20H,2-3,9-10,12-13H2,1H3,(H,34,37,39)(H2,35,36,40) PXVPOPQWCUEDMO-UHFFFAOYSA-N 235578 US9359338, Exe. 188 Serine/threonine-protein kinase B-raf Homo sapiens 19 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235578&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233902 340095240 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410359 Fc1cc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)N2CCOCC2)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C27H25F4N5O4/c28-22-14-18(3-4-23(22)40-21-5-6-32-24(15-21)35-25(37)16-1-2-16)33-26(38)34-19-11-17(27(29,30)31)12-20(13-19)36-7-9-39-10-8-36/h3-6,11-16H,1-2,7-10H2,(H,32,35,37)(H2,33,34,38) CVXUIZBQLGQZAQ-UHFFFAOYSA-N 235579 US9359338, Exe. 189 Serine/threonine-protein kinase B-raf Homo sapiens 29.8 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235579&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233905 340095241 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410360 Fc1cc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)C#N)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C24H17F4N5O3/c25-19-10-16(31-23(35)32-17-8-13(12-29)7-15(9-17)24(26,27)28)3-4-20(19)36-18-5-6-30-21(11-18)33-22(34)14-1-2-14/h3-11,14H,1-2H2,(H,30,33,34)(H2,31,32,35) PDUCXNYIJRWCKG-UHFFFAOYSA-N 235580 US9359338, Exe. 190 Serine/threonine-protein kinase B-raf Homo sapiens 87 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235580&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233863 340095242 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410361 Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1ccc(F)c(c1)C(F)(F)F InChI=1S/C24H20F4N4O3/c1-13-10-16(35-17-8-9-29-21(12-17)32-22(33)14-2-3-14)5-7-20(13)31-23(34)30-15-4-6-19(25)18(11-15)24(26,27)28/h4-12,14H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34) GVMPOIUFFPTGSJ-UHFFFAOYSA-N 235581 US9359338, Exe. 191 Serine/threonine-protein kinase B-raf Homo sapiens 10 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235581&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233856 340095243 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410362 Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C24H21F3N4O3/c1-14-11-18(34-19-9-10-28-21(13-19)31-22(32)15-5-6-15)7-8-20(14)30-23(33)29-17-4-2-3-16(12-17)24(25,26)27/h2-4,7-13,15H,5-6H2,1H3,(H,28,31,32)(H2,29,30,33) KQGDLJKZNRMTIU-UHFFFAOYSA-N 235583 US9359338, Exe. 193 Serine/threonine-protein kinase B-raf Homo sapiens 6.8 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235583&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233903 340095245 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410363 Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cccc(OC(F)(F)F)c1 InChI=1S/C24H21F3N4O4/c1-14-11-17(34-18-9-10-28-21(13-18)31-22(32)15-5-6-15)7-8-20(14)30-23(33)29-16-3-2-4-19(12-16)35-24(25,26)27/h2-4,7-13,15H,5-6H2,1H3,(H,28,31,32)(H2,29,30,33) NWZQWAZWZIECMX-UHFFFAOYSA-N 235584 US9359338, Exe. 194 Serine/threonine-protein kinase B-raf Homo sapiens 8.8 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235584&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234005 340095246 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410364 Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cc(OC(F)(F)F)ccc1F InChI=1S/C24H20F4N4O4/c1-13-10-15(35-16-8-9-29-21(12-16)32-22(33)14-2-3-14)5-7-19(13)30-23(34)31-20-11-17(4-6-18(20)25)36-24(26,27)28/h4-12,14H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34) KEDDRBPCAZCIPR-UHFFFAOYSA-N 235585 US9359338, Exe. 195 Serine/threonine-protein kinase B-raf Homo sapiens 13 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235585&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233866 340095247 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410365 Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1ccc(F)c(OC(F)(F)F)c1 InChI=1S/C24H20F4N4O4/c1-13-10-16(35-17-8-9-29-21(12-17)32-22(33)14-2-3-14)5-7-19(13)31-23(34)30-15-4-6-18(25)20(11-15)36-24(26,27)28/h4-12,14H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34) NYFNROBCKFVABW-UHFFFAOYSA-N 235586 US9359338, Exe. 196 Serine/threonine-protein kinase B-raf Homo sapiens 13 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235586&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233947 340095248 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410366 Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(C)(F)F InChI=1S/C25H23ClF2N4O3/c1-14-11-17(35-18-9-10-29-22(13-18)32-23(33)15-3-4-15)6-8-21(14)31-24(34)30-16-5-7-20(26)19(12-16)25(2,27)28/h5-13,15H,3-4H2,1-2H3,(H,29,32,33)(H2,30,31,34) XVXLKXIFKZFJRL-UHFFFAOYSA-N 235589 US9359338, Exe. 199 Serine/threonine-protein kinase B-raf Homo sapiens 11.7 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235589&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233811 340095251 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410367 Fc1ccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)cc1C(F)(F)F InChI=1S/C23H17F5N4O3/c24-17-5-3-13(9-16(17)23(26,27)28)30-22(34)31-19-6-4-14(10-18(19)25)35-15-7-8-29-20(11-15)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34) YSYCXJHLLAATBI-UHFFFAOYSA-N 235595 US9359338, Exe. 205 Serine/threonine-protein kinase B-raf Homo sapiens 13 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235595&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234006 340095257 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410368 Fc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)cc(c1)C(F)(F)F InChI=1S/C23H17F5N4O3/c24-14-7-13(23(26,27)28)8-15(9-14)30-22(34)31-19-4-3-16(10-18(19)25)35-17-5-6-29-20(11-17)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34) BLEFICDALLFRHM-UHFFFAOYSA-N 235598 US9359338, Exe. 208 Serine/threonine-protein kinase B-raf Homo sapiens 37 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235598&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233875 340095260 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410369 Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1F)C(F)(F)F InChI=1S/C23H17F5N4O3/c24-16-5-3-13(23(26,27)28)9-19(16)31-22(34)30-18-6-4-14(10-17(18)25)35-15-7-8-29-20(11-15)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34) QPWPVJYCRFLDDK-UHFFFAOYSA-N 235599 US9359338, Exe. 209 Serine/threonine-protein kinase B-raf Homo sapiens 9 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235599&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233948 340095261 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410370 Fc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cc(ccc1Cl)C(F)(F)F InChI=1S/C23H17ClF4N4O3/c24-16-5-3-13(23(26,27)28)9-19(16)31-22(34)30-18-6-4-14(10-17(18)25)35-15-7-8-29-20(11-15)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34) ANXZHTXPSJDZAL-UHFFFAOYSA-N 235600 US9359338, Exe. 210 Serine/threonine-protein kinase B-raf Homo sapiens 19 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235600&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233941 340095262 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410371 Fc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C23H18F4N4O3/c24-18-11-16(34-17-8-9-28-20(12-17)31-21(32)13-4-5-13)6-7-19(18)30-22(33)29-15-3-1-2-14(10-15)23(25,26)27/h1-3,6-13H,4-5H2,(H,28,31,32)(H2,29,30,33) ZQYRVJDYQHILFP-UHFFFAOYSA-N 235601 US9359338, Exe. 211 Serine/threonine-protein kinase B-raf Homo sapiens 6.4 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235601&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233812 340095263 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410372 Fc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cc(cc(c1)C(F)(F)F)N1CC(F)(F)C1 InChI=1S/C26H21F6N5O3/c27-20-10-18(40-19-5-6-33-22(11-19)36-23(38)14-1-2-14)3-4-21(20)35-24(39)34-16-7-15(26(30,31)32)8-17(9-16)37-12-25(28,29)13-37/h3-11,14H,1-2,12-13H2,(H,33,36,38)(H2,34,35,39) WFNBWWZDVNXSRQ-UHFFFAOYSA-N 235602 US9359338, Exe. 212 Serine/threonine-protein kinase B-raf Homo sapiens 20.1 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235602&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233816 340095264 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410373 Fc1ccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)cc1OC(F)(F)F InChI=1S/C23H17F5N4O4/c24-16-5-3-13(9-19(16)36-23(26,27)28)30-22(34)31-18-6-4-14(10-17(18)25)35-15-7-8-29-20(11-15)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34) WGWCEHBHEOUGEW-UHFFFAOYSA-N 235605 US9359338, Exe. 215 Serine/threonine-protein kinase B-raf Homo sapiens 19 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235605&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233815 340095267 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410374 CC(F)(F)c1ccnc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)c1 InChI=1S/C23H20F3N5O3/c1-23(25,26)14-6-8-27-19(10-14)31-22(33)29-18-5-4-15(11-17(18)24)34-16-7-9-28-20(12-16)30-21(32)13-2-3-13/h4-13H,2-3H2,1H3,(H,28,30,32)(H2,27,29,31,33) XRODDTARSAGLOF-UHFFFAOYSA-N 235606 US9359338, Exe. 216 Serine/threonine-protein kinase B-raf Homo sapiens 10 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235606&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234029 340095268 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410375 CC(F)(F)c1cccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)c1 InChI=1S/C24H21F3N4O3/c1-24(26,27)15-3-2-4-16(11-15)29-23(33)30-20-8-7-17(12-19(20)25)34-18-9-10-28-21(13-18)31-22(32)14-5-6-14/h2-4,7-14H,5-6H2,1H3,(H,28,31,32)(H2,29,30,33) RQGDSDBEMROIPL-UHFFFAOYSA-N 235607 US9359338, Exe. 217 Serine/threonine-protein kinase B-raf Homo sapiens 8.9 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235607&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233872 340095269 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410376 CC(F)(F)c1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)c1 InChI=1S/C24H20F4N4O3/c1-24(27,28)14-4-6-17(25)20(10-14)31-23(34)30-19-7-5-15(11-18(19)26)35-16-8-9-29-21(12-16)32-22(33)13-2-3-13/h4-13H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34) PLAXNGIKGQRFBQ-UHFFFAOYSA-N 235608 US9359338, Exe. 218 Serine/threonine-protein kinase B-raf Homo sapiens 7.8 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235608&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233860 340095270 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410377 CC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)ccc1Cl InChI=1S/C24H20ClF3N4O3/c1-24(27,28)17-10-14(4-6-18(17)25)30-23(34)31-20-7-5-15(11-19(20)26)35-16-8-9-29-21(12-16)32-22(33)13-2-3-13/h4-13H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34) XVMZDKQISUJCOP-UHFFFAOYSA-N 235609 US9359338, Exe. 219 Serine/threonine-protein kinase B-raf Homo sapiens 8.3 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235609&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233822 340095271 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410378 CC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)ccc1F InChI=1S/C24H20F4N4O3/c1-24(27,28)17-10-14(4-6-18(17)25)30-23(34)31-20-7-5-15(11-19(20)26)35-16-8-9-29-21(12-16)32-22(33)13-2-3-13/h4-13H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34) DRUUNRHVJYGYTP-UHFFFAOYSA-N 235610 US9359338, Exe. 220 Serine/threonine-protein kinase B-raf Homo sapiens 7.1 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235610&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234028 340095272 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410379 Fc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1ccc(C#N)c(Cl)c1 InChI=1S/C23H17ClFN5O3/c24-18-9-15(4-3-14(18)12-26)28-23(32)29-20-6-5-16(10-19(20)25)33-17-7-8-27-21(11-17)30-22(31)13-1-2-13/h3-11,13H,1-2H2,(H,27,30,31)(H2,28,29,32) PCIUPUJAEYWFRQ-UHFFFAOYSA-N 235611 US9359338, Exe. 221 Serine/threonine-protein kinase B-raf Homo sapiens 11 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235611&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233809 340095273 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410380 Cc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1NC(=O)Nc1cc(F)cc(c1)C(F)(F)F InChI=1S/C24H20F4N4O3/c1-13-2-5-18(35-19-6-7-29-21(12-19)32-22(33)14-3-4-14)11-20(13)31-23(34)30-17-9-15(24(26,27)28)8-16(25)10-17/h2,5-12,14H,3-4H2,1H3,(H,29,32,33)(H2,30,31,34) BOIQOTLLDYGXDH-UHFFFAOYSA-N 235614 US9359338, Exe. 224 Serine/threonine-protein kinase B-raf Homo sapiens 29 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235614&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118231354 340095276 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410381 Cc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1NC(=O)Nc1cc(ccc1F)C(F)(F)F InChI=1S/C24H20F4N4O3/c1-13-2-6-16(35-17-8-9-29-21(12-17)32-22(33)14-3-4-14)11-19(13)30-23(34)31-20-10-15(24(26,27)28)5-7-18(20)25/h2,5-12,14H,3-4H2,1H3,(H,29,32,33)(H2,30,31,34) RJQKMPOQVHQEFB-UHFFFAOYSA-N 235615 US9359338, Exe. 225 Serine/threonine-protein kinase B-raf Homo sapiens 11 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235615&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118231352 340095277 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410382 Cc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1NC(=O)Nc1cc(ccc1F)C(C)(F)F InChI=1S/C25H23F3N4O3/c1-14-3-7-17(35-18-9-10-29-22(13-18)32-23(33)15-4-5-15)12-20(14)30-24(34)31-21-11-16(25(2,27)28)6-8-19(21)26/h3,6-13,15H,4-5H2,1-2H3,(H,29,32,33)(H2,30,31,34) FUABMLOANOSRDB-UHFFFAOYSA-N 235617 US9359338, Exe. 227 Serine/threonine-protein kinase B-raf Homo sapiens 27 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235617&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118231353 340095279 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410383 Cc1cc(NC(=O)Nc2ccc(F)c(c2)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C24H20F4N4O3/c1-13-10-15(30-23(34)31-16-4-6-19(25)18(11-16)24(26,27)28)5-7-20(13)35-17-8-9-29-21(12-17)32-22(33)14-2-3-14/h4-12,14H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34) BHMPFCRUQAZDJH-UHFFFAOYSA-N 235620 US9359338, Exe. 230 Serine/threonine-protein kinase B-raf Homo sapiens 20.7 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235620&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233951 340095282 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410384 Cc1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C24H21F3N4O3/c1-14-11-18(30-23(33)29-17-4-2-3-16(12-17)24(25,26)27)7-8-20(14)34-19-9-10-28-21(13-19)31-22(32)15-5-6-15/h2-4,7-13,15H,5-6H2,1H3,(H,28,31,32)(H2,29,30,33) UHWVBAWEGIDZLA-UHFFFAOYSA-N 235621 US9359338, Exe. 231 Serine/threonine-protein kinase B-raf Homo sapiens 12.5 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235621&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118234007 340095283 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410385 Cc1cc(NC(=O)Nc2cccc(OC(F)(F)F)c2)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C24H21F3N4O4/c1-14-11-17(30-23(33)29-16-3-2-4-19(12-16)35-24(25,26)27)7-8-20(14)34-18-9-10-28-21(13-18)31-22(32)15-5-6-15/h2-4,7-13,15H,5-6H2,1H3,(H,28,31,32)(H2,29,30,33) QBRHTMDADHIQAG-UHFFFAOYSA-N 235622 US9359338, Exe. 232 Serine/threonine-protein kinase B-raf Homo sapiens 14 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235622&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233869 340095284 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410386 Cc1cc(NC(=O)Nc2cc(ccc2F)C(C)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C25H23F3N4O3/c1-14-11-17(30-24(34)31-20-12-16(25(2,27)28)5-7-19(20)26)6-8-21(14)35-18-9-10-29-22(13-18)32-23(33)15-3-4-15/h5-13,15H,3-4H2,1-2H3,(H,29,32,33)(H2,30,31,34) UPJMWOZAGHFAMT-UHFFFAOYSA-N 235624 US9359338, Exe. 234 Serine/threonine-protein kinase B-raf Homo sapiens 16 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235624&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233821 340095286 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410387 Cc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(C)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C25H23ClF2N4O3/c1-14-11-16(30-24(34)31-17-5-7-20(26)19(12-17)25(2,27)28)6-8-21(14)35-18-9-10-29-22(13-18)32-23(33)15-3-4-15/h5-13,15H,3-4H2,1-2H3,(H,29,32,33)(H2,30,31,34) CFMORAKHQKGHJV-UHFFFAOYSA-N 235625 US9359338, Exe. 235::US9359338, Exe. 236 Serine/threonine-protein kinase B-raf Homo sapiens 22 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235625&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233949 340095287 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410388 Cc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(C)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1 InChI=1S/C25H23ClF2N4O3/c1-14-11-16(30-24(34)31-17-5-7-20(26)19(12-17)25(2,27)28)6-8-21(14)35-18-9-10-29-22(13-18)32-23(33)15-3-4-15/h5-13,15H,3-4H2,1-2H3,(H,29,32,33)(H2,30,31,34) CFMORAKHQKGHJV-UHFFFAOYSA-N 235625 US9359338, Exe. 235::US9359338, Exe. 236 Serine/threonine-protein kinase B-raf Homo sapiens 21 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235625&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233949 340095287 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410389 FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)cc(OCC2CNC2)c1 InChI=1S/C27H26F3N5O4/c28-27(29,30)18-9-20(11-23(10-18)38-15-16-13-31-14-16)34-26(37)33-19-3-5-21(6-4-19)39-22-7-8-32-24(12-22)35-25(36)17-1-2-17/h3-12,16-17,31H,1-2,13-15H2,(H,32,35,36)(H2,33,34,37) JHOBFPMJKZVXEQ-UHFFFAOYSA-N 235627 US9359338, Exe. 237 Serine/threonine-protein kinase B-raf Homo sapiens 3.7 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235627&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90019802 340095288 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410390 Nc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F InChI=1S/C23H19F4N5O3/c24-18-10-15(30-22(34)31-16-8-13(23(25,26)27)7-14(28)9-16)3-4-19(18)35-17-5-6-29-20(11-17)32-21(33)12-1-2-12/h3-12H,1-2,28H2,(H,29,32,33)(H2,30,31,34) ZPHTXJMXXYVIIA-UHFFFAOYSA-N 235629 US9359338, Exe. 239 Serine/threonine-protein kinase B-raf Homo sapiens 7 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235629&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118233870 340095290 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 410391 CN1CC(C1)Oc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)cc(c1)C(F)(F)F InChI=1S/C27H26F3N5O4/c1-35-14-23(15-35)39-22-11-17(27(28,29)30)10-19(12-22)33-26(37)32-18-4-6-20(7-5-18)38-21-8-9-31-24(13-21)34-25(36)16-2-3-16/h4-13,16,23H,2-3,14-15H2,1H3,(H,31,34,36)(H2,32,33,37) AGYPJIVSNGSKON-UHFFFAOYSA-N 235631 US9359338, Exe. 241 Serine/threonine-protein kinase B-raf Homo sapiens 9.1 30.00 C US Patent 10.7270/Q2KH0M7N aid1803017 US9359338 Zhang, D; Zhang, R; Zhong, B; Shih, C CROWN BIOSCIENCE INC. (Taiwan) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235631&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90029424 340095292 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 415920 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12 InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34) JETCTCUSGZDEGL-UHFFFAOYSA-N 238345 US9388165, 1 Serine/threonine-protein kinase B-raf Homo sapiens 87 US Patent 10.7270/Q2F76BF9 aid1803154 US9388165 Bae, IH; Han, SM; Kwak, EJ; Ahn, YG; Suh, KH Hanmi Pharm. Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238345&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118090792 340131706 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 421746 Nc1c(c(nn1-c1c(Cl)cc(Cl)cc1Cl)-c1ccncc1)-c1ccc(F)cc1 InChI=1S/C20H12Cl3FN4/c21-13-9-15(22)19(16(23)10-13)28-20(25)17(11-1-3-14(24)4-2-11)18(27-28)12-5-7-26-8-6-12/h1-10H,25H2 MOHYPRXHKRXDSE-UHFFFAOYSA-N 50379214 CHEMBL2011291::US9416123, 6 Serine/threonine-protein kinase B-raf Homo sapiens 270 7.5 30.00 C US Patent 10.7270/Q2V123PP aid1803274 US9416123 Burnet, MW; Thaher, BA; Ehlert, J; Kubbutat, M; Schaechtele, C; Totzke, F Synovo GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379214&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 56924694 160858297 CHEMBL2011291 ZINC84604180 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50074640 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) YZDJQTHVDDOVHR-UHFFFAOYSA-N 25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720 Serine/threonine-protein kinase B-raf Homo sapiens 46 ChEMBL 10.1021/jm300613w 10.7270/Q29K4CC8 22808911 Wang, X; Kim, J Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25617&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 324 3C4C,4WO5 24180719 56412907 DB06999 5703 ZINC39059267 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50074641 Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1Nc1ncccc1-c1ncnc2nc[nH]c12 InChI=1S/C26H19ClN8/c1-15-4-9-19-18(10-12-29-24(19)34-17-7-5-16(27)6-8-17)21(15)35-25-20(3-2-11-28-25)22-23-26(32-13-30-22)33-14-31-23/h2-14H,1H3,(H,28,35)(H,29,34)(H,30,31,32,33) KKVYYGGCHJGEFJ-UHFFFAOYSA-N 35327 pyridylpurine aminoisoquinoline, 1 Serine/threonine-protein kinase B-raf Homo sapiens 1 ChEMBL 10.1021/jm300613w 10.7270/Q29K4CC8 22808911 Wang, X; Kim, J Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35327&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search L1E 3IDP 44223999 85753403 ZINC39300628 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50074643 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) YZDJQTHVDDOVHR-UHFFFAOYSA-N 25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720 Serine/threonine-protein kinase B-raf Homo sapiens 160 ChEMBL 10.1021/jm300613w 10.7270/Q29K4CC8 22808911 Wang, X; Kim, J Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25617&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 324 3C4C,4WO5 24180719 56412907 DB06999 5703 ZINC39059267 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50074644 OCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,18,24H,2,4,9-10H2 RIGIGAFKKVBACY-UHFFFAOYSA-N 25628 2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethan-1-ol::AR00341677::CHEMBL525191::GDC-0879 Serine/threonine-protein kinase B-raf Homo sapiens <1000 ChEMBL 10.1021/jm300613w 10.7270/Q29K4CC8 22808911 Wang, X; Kim, J Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25628&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91448975 56412918 CHEMBL525191 ZINC34640412 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50074645 CN(C)CCOc1ccc(cc1)-c1nc(c([nH]1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1 InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,24H,6,10,15-16H2,1-2H3,(H,29,30) ZLWRKMXLUCZVAR-UHFFFAOYSA-N 25391 CHEMBL200622::SB-590885::SB590885::[2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)-1H-imidazol-2-yl}phenoxy)ethyl]dimethylamine Serine/threonine-protein kinase B-raf Homo sapiens 0.30 ChEMBL 10.1021/jm300613w 10.7270/Q29K4CC8 22808911 Wang, X; Kim, J Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25391&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2FB8 91369525 56374530 CHEMBL200622 ZINC89224159 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50083766 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Oc2ccc3nc(NC(=O)C4CCOCC4)cn3n2)c1 InChI=1S/C26H22F3N5O4/c27-26(28,29)18-4-1-3-17(13-18)25(36)30-19-5-2-6-20(14-19)38-23-8-7-22-31-21(15-34(22)33-23)32-24(35)16-9-11-37-12-10-16/h1-8,13-16H,9-12H2,(H,30,36)(H,32,35) WFIZKEJDQNESRZ-UHFFFAOYSA-N 50432397 CHEMBL2348989 Serine/threonine-protein kinase B-raf Homo sapiens 43 ChEMBL 10.1016/j.ejmech.2013.11.018 10.7270/Q2F1917Z 24424304 El-Nassan, HB Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432397&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57386061 164161272 CHEMBL2348989 ZINC95601126 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50083767 O=C1NC(=S)NC(=O)C1=Cc1ccc(o1)-c1ccc2OCOc2c1 InChI=1S/C16H10N2O5S/c19-14-10(15(20)18-16(24)17-14)6-9-2-4-11(23-9)8-1-3-12-13(5-8)22-7-21-12/h1-6H,7H2,(H2,17,18,19,20,24) WGEYBHFHUSJOKS-UHFFFAOYSA-N 50006649 CHEMBL3235904 Serine/threonine-protein kinase B-raf Homo sapiens 1150 ChEMBL 10.1016/j.ejmech.2013.11.018 10.7270/Q2F1917Z 24424304 El-Nassan, HB Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50006649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50006649&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 66554192 242057061 CHEMBL3235904 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50083768 O\N=C1/CCc2cc(ccc12)-c1cn(nc1-c1ccncc1)C1CCNCC1 InChI=1S/C22H23N5O/c28-26-21-4-2-16-13-17(1-3-19(16)21)20-14-27(18-7-11-24-12-8-18)25-22(20)15-5-9-23-10-6-15/h1,3,5-6,9-10,13-14,18,24,28H,2,4,7-8,11-12H2/b26-21+ KWEFZSZCLBHIEQ-YYADALCUSA-N 50006650 CHEMBL526479 Serine/threonine-protein kinase B-raf Homo sapiens 9.0 ChEMBL 10.1016/j.ejmech.2013.11.018 10.7270/Q2F1917Z 24424304 El-Nassan, HB Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50006650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50006650&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search SM5 3OMV,3D4Q 11653652 242057062 CHEMBL526479 DB08553 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50083771 O\N=C1/CCc2cc(ccc12)-c1cn(nc1-c1ccncc1)C1CCNCC1 InChI=1S/C22H23N5O/c28-26-21-4-2-16-13-17(1-3-19(16)21)20-14-27(18-7-11-24-12-8-18)25-22(20)15-5-9-23-10-6-15/h1,3,5-6,9-10,13-14,18,24,28H,2,4,7-8,11-12H2/b26-21+ KWEFZSZCLBHIEQ-YYADALCUSA-N 50006650 CHEMBL526479 Serine/threonine-protein kinase B-raf Homo sapiens 0.030000 ChEMBL 10.1016/j.ejmech.2013.11.018 10.7270/Q2F1917Z 24424304 El-Nassan, HB Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50006650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50006650&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search SM5 3OMV,3D4Q 11653652 242057062 CHEMBL526479 DB08553 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50083772 CN1CCC(CC1)n1cc(c(n1)-c1ccncc1)-c1ccc2\C(CCc2c1)=N\O InChI=1S/C23H25N5O/c1-27-12-8-19(9-13-27)28-15-21(23(25-28)16-6-10-24-11-7-16)18-2-4-20-17(14-18)3-5-22(20)26-29/h2,4,6-7,10-11,14-15,19,29H,3,5,8-9,12-13H2,1H3/b26-22+ HRKVZMGUPVYSKL-XTCLZLMSSA-N 50006652 CHEMBL498674 Serine/threonine-protein kinase B-raf Homo sapiens 0.340000 ChEMBL 10.1016/j.ejmech.2013.11.018 10.7270/Q2F1917Z 24424304 El-Nassan, HB Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50006652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50006652&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11639637 242057064 CHEMBL498674 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50083773 O\N=C1/CCc2cc(ccc12)-c1cn(nc1-c1ccncc1)C1CCOCC1 InChI=1S/C22H22N4O2/c27-25-21-4-2-16-13-17(1-3-19(16)21)20-14-26(18-7-11-28-12-8-18)24-22(20)15-5-9-23-10-6-15/h1,3,5-6,9-10,13-14,18,27H,2,4,7-8,11-12H2/b25-21+ RZCDDUDKDKUXLC-NJNXFGOHSA-N 50006653 CHEMBL497671 Serine/threonine-protein kinase B-raf Homo sapiens 0.220000 ChEMBL 10.1016/j.ejmech.2013.11.018 10.7270/Q2F1917Z 24424304 El-Nassan, HB Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50006653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50006653&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11624965 242057065 CHEMBL497671 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50083775 CCN(CCO)CCCOc1ccc2c(Nc3cccc(NC(=O)Nc4ccc(F)c(Cl)c4)c3)ncnc2c1 InChI=1S/C28H30ClFN6O3/c1-2-36(12-13-37)11-4-14-39-22-8-9-23-26(17-22)31-18-32-27(23)33-19-5-3-6-20(15-19)34-28(38)35-21-7-10-25(30)24(29)16-21/h3,5-10,15-18,37H,2,4,11-14H2,1H3,(H,31,32,33)(H2,34,35,38) ZBXDUDJPTQSVHR-UHFFFAOYSA-N 50006651 CHEMBL3133758 Serine/threonine-protein kinase B-raf Homo sapiens 22 ChEMBL 10.1016/j.ejmech.2013.11.018 10.7270/Q2F1917Z 24424304 El-Nassan, HB Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50006651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50006651&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57524403 242057063 CHEMBL3133758 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50091734 CC(NC(=O)c1cccc(c1)-c1ccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cc1)c1ccccc1 InChI=1S/C29H23ClF3N3O2/c1-18(19-6-3-2-4-7-19)34-27(37)22-9-5-8-21(16-22)20-10-12-23(13-11-20)35-28(38)36-24-14-15-26(30)25(17-24)29(31,32)33/h2-18H,1H3,(H,34,37)(H2,35,36,38) SZAPQHXYXAURBX-UHFFFAOYSA-N 50011572 CHEMBL3262871 Serine/threonine-protein kinase B-raf Homo sapiens >50000 ChEMBL 10.1016/j.ejmech.2014.03.020 10.7270/Q2G73G8W 24675135 Lu, C; Tang, K; Li, Y; Li, P; Lin, Z; Yin, D; Chen, X; Huang, H Peking Union Medical College & Chinese Academy of Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011572&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90655989 103924104 CHEMBL3262871 ZINC03870513 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50091735 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 43 ChEMBL 10.1016/j.ejmech.2014.03.020 10.7270/Q2G73G8W 24675135 Lu, C; Tang, K; Li, Y; Li, P; Lin, Z; Yin, D; Chen, X; Huang, H Peking Union Medical College & Chinese Academy of Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50096779 COc1ccc(Oc2cc(C)c(-c3csc(NC(=O)c4ccnc(F)c4)n3)c(C)c2)cc1 InChI=1S/C24H20FN3O3S/c1-14-10-19(31-18-6-4-17(30-3)5-7-18)11-15(2)22(14)20-13-32-24(27-20)28-23(29)16-8-9-26-21(25)12-16/h4-13H,1-3H3,(H,27,28,29) JZGFZITYBNEDHQ-UHFFFAOYSA-N 50015314 CHEMBL3263869 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1021/jm401990s 10.7270/Q23J3FH9 24773549 Lee, YS; Chuang, SH; Huang, LY; Lai, CL; Lin, YH; Yang, JY; Liu, CW; Yang, SC; Lin, HS; Chang, CC; Lai, JY; Jian, PS; Lam, K; Chang, JM; Lau, JY; Huang, JJ Development Center for Biotechnology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50015314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50015314&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53389651 103927133 CHEMBL3263869 ZINC28761613 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50105046 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 136 ChEMBL 10.1016/j.ejmech.2014.05.025 10.7270/Q2K075VT 24858546 Diez-Cecilia, E; Kelly, B; Perez, C; Zisterer, DM; Nevin, DK; Lloyd, DG; Rozas, I Trinity College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50105047 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 120 ChEMBL 10.1016/j.ejmech.2014.05.025 10.7270/Q2K075VT 24858546 Diez-Cecilia, E; Kelly, B; Perez, C; Zisterer, DM; Nevin, DK; Lloyd, DG; Rozas, I Trinity College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50165458 C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 UIARLYUEJFELEN-LROUJFHJSA-N 50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2V9 5WNJ,4OTG 126565 104162421 CHEMBL603469 5672 ZINC03781738 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50160356 Cc1cc(ccc1-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc(O)c1)N1C[C@@H]2C[C@H]1CN2 InChI=1S/C29H26N6O/c1-18-13-22(34-17-21-15-23(34)16-32-21)5-6-25(18)26-9-12-31-29-27(20-3-2-4-24(36)14-20)28(33-35(26)29)19-7-10-30-11-8-19/h2-14,21,23,32,36H,15-17H2,1H3/t21-,23-/m0/s1 NHSOOSWIKATDPJ-GMAHTHKFSA-N 50026028 CHEMBL1087001 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026028&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880076 277286607 CHEMBL1087001 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50160357 CN1C2CCC1CN(C2)c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(Cl)c(O)c1 InChI=1S/C30H27ClN6O/c1-35-23-7-8-24(35)18-36(17-23)22-5-2-19(3-6-22)26-12-15-33-30-28(21-4-9-25(31)27(38)16-21)29(34-37(26)30)20-10-13-32-14-11-20/h2-6,9-16,23-24,38H,7-8,17-18H2,1H3 VDZOQIIFFIDBKL-UHFFFAOYSA-N 50026030 CHEMBL1080833 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026030&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44226449 277286608 CHEMBL1080833 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50160359 CN1C[C@@H]2C[C@H]1CN2c1ccc(c(F)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc(O)c1 InChI=1S/C29H25FN6O/c1-34-16-22-14-21(34)17-35(22)20-5-6-24(25(30)15-20)26-9-12-32-29-27(19-3-2-4-23(37)13-19)28(33-36(26)29)18-7-10-31-11-8-18/h2-13,15,21-22,37H,14,16-17H2,1H3/t21-,22-/m0/s1 BBYIZUORJHYAIY-VXKWHMMOSA-N 50026010 CHEMBL1087013 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026010&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880138 277286603 CHEMBL1087013 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50160363 CN1C[C@@H]2C[C@H]1CN2c1ccc(c(C)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(F)c(O)c1 InChI=1S/C30H27FN6O/c1-18-13-21(36-17-22-15-23(36)16-35(22)2)4-5-24(18)26-9-12-33-30-28(20-3-6-25(31)27(38)14-20)29(34-37(26)30)19-7-10-32-11-8-19/h3-14,22-23,38H,15-17H2,1-2H3/t22-,23-/m0/s1 FBURAFZZOWGKPS-GOTSBHOMSA-N 50026014 CHEMBL1081284 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026014&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880218 277286605 CHEMBL1081284 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50160364 CN1C[C@@H]2C[C@H]1CN2c1ccc(c(C)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc(O)c1 InChI=1S/C30H28N6O/c1-19-14-22(35-18-23-16-24(35)17-34(23)2)6-7-26(19)27-10-13-32-30-28(21-4-3-5-25(37)15-21)29(33-36(27)30)20-8-11-31-12-9-20/h3-15,23-24,37H,16-18H2,1-2H3/t23-,24-/m0/s1 RRSJWNKMMLAHOA-ZEQRLZLVSA-N 50026013 CHEMBL1086882 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026013&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880137 277286604 CHEMBL1086882 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50160365 Oc1cccc(c1)-c1c(nn2c(ccnc12)-c1ccc(cc1F)N1C[C@@H]2C[C@H]1CN2)-c1ccncc1 InChI=1S/C28H23FN6O/c29-24-14-20(34-16-19-13-21(34)15-32-19)4-5-23(24)25-8-11-31-28-26(18-2-1-3-22(36)12-18)27(33-35(25)28)17-6-9-30-10-7-17/h1-12,14,19,21,32,36H,13,15-16H2/t19-,21-/m0/s1 BNFCWDYUUFZZDC-FPOVZHCZSA-N 50025981 CHEMBL1088437 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50025981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50025981&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880102 277286602 CHEMBL1088437 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50160366 Oc1cccc(c1)-c1c(nn2c(ccnc12)-c1ccc(cc1Cl)N1C[C@@H]2C[C@H]1CN2)-c1ccncc1 InChI=1S/C28H23ClN6O/c29-24-14-20(34-16-19-13-21(34)15-32-19)4-5-23(24)25-8-11-31-28-26(18-2-1-3-22(36)12-18)27(33-35(25)28)17-6-9-30-10-7-17/h1-12,14,19,21,32,36H,13,15-16H2/t19-,21-/m0/s1 QAIFKOURADMRAF-FPOVZHCZSA-N 50025947 CHEMBL1088438 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50025947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50025947&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880103 103935693 CHEMBL1088438 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50160367 Oc1cc(ccc1F)-c1c(nn2c(ccnc12)-c1ccc(cc1)N1C[C@@H]2C[C@H]1CN2)-c1ccncc1 InChI=1S/C28H23FN6O/c29-23-6-3-19(13-25(23)36)26-27(18-7-10-30-11-8-18)33-35-24(9-12-31-28(26)35)17-1-4-21(5-2-17)34-16-20-14-22(34)15-32-20/h1-13,20,22,32,36H,14-16H2/t20-,22-/m0/s1 KRSYZLFRSXTAHG-UNMCSNQZSA-N 50025938 CHEMBL1088439 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50025938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50025938&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880104 103935684 CHEMBL1088439 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50160368 CN1C[C@@H]2C[C@H]1CN2c1ccc(c(Cl)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc(O)c1 InChI=1S/C29H25ClN6O/c1-34-16-22-14-21(34)17-35(22)20-5-6-24(25(30)15-20)26-9-12-32-29-27(19-3-2-4-23(37)13-19)28(33-36(26)29)18-7-10-31-11-8-18/h2-13,15,21-22,37H,14,16-17H2,1H3/t21-,22-/m0/s1 DODFKUBADJWIEL-VXKWHMMOSA-N 50026023 CHEMBL1080931 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026023&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46198375 277286606 CHEMBL1080931 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50160369 CN1C[C@@H]2C[C@H]1CN2c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(F)c(O)c1 InChI=1S/C29H25FN6O/c1-34-16-23-15-22(34)17-35(23)21-5-2-18(3-6-21)25-10-13-32-29-27(20-4-7-24(30)26(37)14-20)28(33-36(25)29)19-8-11-31-12-9-19/h2-14,22-23,37H,15-17H2,1H3/t22-,23-/m0/s1 YLZMRFLWQLYPJH-GOTSBHOMSA-N 50026022 CHEMBL1081283 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026022&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880217 103935764 CHEMBL1081283 ZINC40631764 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50168936 Fc1cc(cc(F)c1-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12)N1C[C@@H]2C[C@H]1CN2C1CCC1 50026210 CHEMBL1276196 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026210&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49837402 277286614 CHEMBL1276196 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50168938 CN1C[C@@H]2C[C@H]1CN2c1ccc(c(F)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(F)c2[nH]ncc12 50026212 CHEMBL1276185 Serine/threonine-protein kinase B-raf Homo sapiens <0.100000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026212&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836965 277286616 CHEMBL1276185 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50168939 CC(C)CN1C[C@@H]2C[C@H]1CN2c1cc(F)c(c(F)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 50026206 CHEMBL1276195 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026206&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49837401 277286610 CHEMBL1276195 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50168940 CN1C[C@@H]2C[C@H]1CN2c1ccc(c(C)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(F)c2[nH]ncc12 50026211 CHEMBL1276184 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026211&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836964 277286615 CHEMBL1276184 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50168941 CC(C)N1C[C@@H]2C[C@H]1CN2c1cc(F)c(c(F)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 50026205 CHEMBL1276194 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026205&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49837301 277286609 CHEMBL1276194 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50168942 CN1C[C@@H]2C[C@H]1CN2c1ccc(c(Br)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 50026209 CHEMBL1276171 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026209&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836541 277286613 CHEMBL1276171 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50168943 CCN1C[C@@H]2C[C@H]1CN2c1cc(F)c(c(F)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 50026208 CHEMBL1276193 Serine/threonine-protein kinase B-raf Homo sapiens <0.320000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026208&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49837300 277286612 CHEMBL1276193 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50168944 CN1C[C@@H]2C[C@H]1CN2c1ccc(c(Cl)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 50026207 CHEMBL1276170 Serine/threonine-protein kinase B-raf Homo sapiens <0.100000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026207&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836540 277286611 CHEMBL1276170 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50165900 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50184811 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31) JOOXLOJCABQBSG-UHFFFAOYSA-N 50332294 CHEMBL1287853::N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide::US10112907, Example 00018::US10730860, TABLE 1.3::US10766894, Compound TABLE 1.3::US11203595, TABLE 1.3::US11384069, Example T-5 Serine/threonine-protein kinase B-raf Homo sapiens 9800 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332294&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2TA 4OGJ,4PS5,6VNE 16722836 123111409 CHEMBL1287853 5716 ZINC19862646 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50185845 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50185863 O=C(N1CCNCC1)c1ccc(\C=C\c2n[nH]c3ccccc23)cc1 InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+ YYLKKYCXAOBSRM-JXMROGBWSA-N 50355496 CHEMBL1908397 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355496&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11427553 136959520 CHEMBL1908397 ZINC43201999 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50185865 CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34) GUBJNPWVIUFSTR-UHFFFAOYSA-N 50355499 CHEMBL1908395::CHEMBL1908842 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355499&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11676971 136959523 CHEMBL1908842CHEMBL1908395 ZINC38226716 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50185866 COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 InChI=1S/C24H24N4O5S/c1-14(23-26-9-10-34-23)27-24(29)28-17-6-5-15(11-20(17)30-2)33-19-7-8-25-18-13-22(32-4)21(31-3)12-16(18)19/h5-14H,1-4H3,(H2,27,28,29) SHPFDGWALWEPGS-UHFFFAOYSA-N 50355494 CHEMBL1908396 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355494&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9869779 136959518 CHEMBL1908396 ZINC13975055 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50190138 COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1 InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35) QQWUGDVOUVUTOY-UHFFFAOYSA-N 482158 BDBM50242742::TAE684 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=482158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=482158&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16038120 443551321 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50191222 CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1 InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27) LHNIIDJUOCFXAP-UHFFFAOYSA-N 25028 4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine::GDC-0941::GDC0941::US10112932, pictilisib::US10851091, Compound pictilisib Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25028&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search GD9 3DBS,2Y3A,2WXP 17755052 56374172 65326 ZINC16052714 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50181502 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50190201 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1 OYONTEXKYJZFHA-SSHUPFPWSA-N 50242737 (R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one::CHEMBL450786::PHA-665752::TCMDC-125885 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242737&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10461815 104099202 CHEMBL450786 5700 ZINC03938668 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50179467 Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37) HHZIURLSWUIHRB-UHFFFAOYSA-N 50237710 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide::AMN 107::AMN107::CHEMBL255863::NILOTINIB::US11649218, Example Nilotinib Serine/threonine-protein kinase B-raf Homo sapiens 1700 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50237710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50237710&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search NIL 5MO4,3CS9,3GP0 644241 104056419 52172 CHEMBL255863 DB04868 5697 ZINC06716957 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50184931 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Serine/threonine-protein kinase B-raf Homo sapiens 570 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50187085 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Serine/threonine-protein kinase B-raf Homo sapiens 730 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50180609 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50181679 CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26) VAARYSWULJUGST-UHFFFAOYSA-N 6568 6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfanyl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL386051::PD-173955::PD173955::US11136333, Compound PD173955 Serine/threonine-protein kinase B-raf Homo sapiens 5.7 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6568&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search P17 1M52,5IA3 447077 8036145 49791 CHEMBL386051 DB02567 5699 ZINC02047743 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50186101 COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31) UBPYILGKFZZVDX-UHFFFAOYSA-N 4552 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile::4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile::BOSUTINIB::CHEMBL288441::SKI-606 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4552&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search DB8 6OP9,5AJQ,4MXO,4MXY,4MXX,4MXZ,3SOA,5VC3,6FDY,5I9X,3UE4,4QMN,5VCY 5328940 8034215 39112 CHEMBL288441 DB06616 5710 ZINC22448983 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50178561 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50181720 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50182883 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) YZDJQTHVDDOVHR-UHFFFAOYSA-N 25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720 Serine/threonine-protein kinase B-raf Homo sapiens 330 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25617&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 324 3C4C,4WO5 24180719 56412907 DB06999 5703 ZINC39059267 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50182908 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50186156 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Serine/threonine-protein kinase B-raf Homo sapiens 3300 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50188269 CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 50322823 (S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide::AFATINIB::CHEMBL1173655::US10085983, Compound BIBW2992::US10196365, Afatinib::US10435400, Compound BIBW2992::US9388170, Afatinib::US9890168, Compound BIBW2992::WO2022090481, Example afatinib Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322823&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 0WM 4G5J 10184653 104144352 61390 CHEMBL1173655 DB08916 5667 ZINC03976838 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50190370 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50190390 C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 UIARLYUEJFELEN-LROUJFHJSA-N 50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2V9 5WNJ,4OTG 126565 104162421 CHEMBL603469 5672 ZINC03781738 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50179674 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50188291 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50190431 N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 50355501 INCB-018424::RUXOLITINIB::RUXOLITINIB PHOSPHATE::US10112907, Example 00016::US10766894, Compound TABLE 1.1::US10875847, Compound JAKAFI::US11203595, TABLE 1.1::US11279703, TABLE 6.147 Serine/threonine-protein kinase B-raf Homo sapiens 4200 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355501&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search RXT 6VNK,6WTN,6VGL,4U5J,7F3G 25126798 136959525 66919 DB08877 ZINC43207851 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50188367 C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1 WCWUXEGQKLTGDX-LLVKDONJSA-N 50184807 (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol::(R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol::BMS-540215::CHEMBL377300 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50184807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50184807&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11234052 104069124 CHEMBL377300 5671 ZINC13684256 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50188385 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50189428 CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12 InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34) HZTYDQRUAWIZRE-UHFFFAOYSA-N 27817 2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-dihydro-1H-indol-6-yl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluoro-N-methylbenzamide::pyrrolo[2,3-d]pyrimidine deriv., 40 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27817&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25182616 57560329 5683 ZINC43202844 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50186361 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50188417 Clc1cccc(Cl)c1C(=O)Nc1cn[nH]c1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 24654 4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-pyrazole-3,4-diamido::AT7519::JMC514986 Compound 33::pyrazole diamide, 33 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24654&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 56269605 5662 ZINC16052857 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50188418 CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc12 InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19) MFAQYJIYDMLAIM-UHFFFAOYSA-N 36409 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol, PP242::CID24905147::US10172858, Table 2.1::US9828378, # 1 Serine/threonine-protein kinase B-raf Homo sapiens 880 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36409&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search P2X 4JT5 24905147 117643995 ZINC36056301 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50177724 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50182022 COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24) JRNJNYBQQYBCLE-UHFFFAOYSA-N 12621 2,4-Diamino-5-ketopyrimidine 39::5-[(2,3-difluoro-6-methoxyphenyl)carbonyl]-2-N-(1-methanesulfonylpiperidin-4-yl)pyrimidine-2,4-diamine::R547::[4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12621&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search LIA 2FVD 6918852 46513075 DB08094 5707 ZINC13983251 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50184280 COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30) NHHQJBCNYHBUSI-UHFFFAOYSA-N 60665 BDBM50249542::US9145414, R406::US9212178, R406 Serine/threonine-protein kinase B-raf Homo sapiens 240 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60665&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 585 3PIY,3FQS 11213558 316921779 DB07159 ZINC13555629 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50187542 Fc1ccc(C(=O)NOCC2CC2)c(Nc2ccc(I)cc2Cl)c1F InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24) GFMMXOIFOQCCGU-UHFFFAOYSA-N 50132260 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide::2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide::CHEMBL105442::CI-1040::PD-18435::PD-184352::US8575391, 341 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50132260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50132260&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 6918454 104023279 CHEMBL105442 5676 ZINC01489691 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50183258 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50183294 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Serine/threonine-protein kinase B-raf Homo sapiens 710 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50186584 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50177962 COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28- XZXHXSATPCNXJR-ZIADKAODSA-N 50026612 BIBF-1120::Nintedanib::US10981896, Compound Nintedanib::US11046672, Nintedanib::US11208381, Nintedanib::Vargatef Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026612&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search XIN 5MAF,6NEC,3C7Q,5TE0 9809715 277286638 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50185541 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50186650 Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) CYOHGALHFOKKQC-UHFFFAOYSA-N 50355497 AZD-6244::CHEMBL1614701 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355497&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 3EW 4U7Z,7JUZ,7JUT,7M0T 10127622 136959521 CHEMBL1614701 ZINC31773258 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50188698 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50177997 OCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,18,24H,2,4,9-10H2 RIGIGAFKKVBACY-UHFFFAOYSA-N 25628 2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethan-1-ol::AR00341677::CHEMBL525191::GDC-0879 Serine/threonine-protein kinase B-raf Homo sapiens 0.190000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25628&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91448975 56412918 CHEMBL525191 ZINC34640412 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50182311 Cc1cnc2c(NCCN)nc3ccc(C)cc3n12 InChI=1S/C14H17N5/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18) PSPFQEBFYXJZEV-UHFFFAOYSA-N 25919 BMS-345541::BMS345541::CHEMBL471496::N-(2-aminoethyl)-3,12-dimethyl-2,5,8-triazatricyclo[7.4.0.0^{2,6}]trideca-1(13),3,5,7,9,11-hexaen-7-amine Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25919&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9813758 56413207 CHEMBL471496 5669 ZINC13285379 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50186758 Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1 InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24) UJIAQDJKSXQLIT-UHFFFAOYSA-N 25084 3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol::JMC504279 Compound 6::TG100-115 Serine/threonine-protein kinase B-raf Homo sapiens 2000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25084&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search B6J 5WNK 10427712 56374226 5715 ZINC06718666 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50186767 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50181311 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50184656 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Serine/threonine-protein kinase B-raf Homo sapiens 1300 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50184658 Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4ncccc4c3)n2n1 InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 BCZUAADEACICHN-UHFFFAOYSA-N 60589 6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline (4)::BDBM50355498 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60589&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search SX8 3DKF,3DKG 16187854 24782328 DB08584 ZINC15962404 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50185769 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50187859 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50191091 COc1c(Cl)cc2c3ccncc3[nH]c2c1NC(=O)c1cccnc1C InChI=1S/C19H15ClN4O2/c1-10-11(4-3-6-22-10)19(25)24-17-16-13(8-14(20)18(17)26-2)12-5-7-21-9-15(12)23-16/h3-9,23H,1-2H3,(H,24,25) ZNOLRTPMNMPLHY-UHFFFAOYSA-N 50309910 CHEMBL608154::ML-120B::N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylnicotinamide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50309910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50309910&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9929127 104164271 CHEMBL608154 5694 ZINC06717113 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50181356 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Serine/threonine-protein kinase B-raf Homo sapiens 1200 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50181360 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Serine/threonine-protein kinase B-raf Homo sapiens 2900 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50185826 COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)NC4=CCC(F)C=C4)cc3F)ccnc2cc1OCCCN1CCOCC1 InChI=1S/C34H36F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3,5-9,12,19-22H,2,4,10-11,13-18H2,1H3,(H,38,41)(H,39,42) SEJGTFPOEJWEGG-UHFFFAOYSA-N 50355504 CHEMBL1908393 Serine/threonine-protein kinase B-raf Homo sapiens 3500 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355504&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57399640 136959528 CHEMBL1908393 ZINC73140828 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50185827 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 ZHJGWYRLJUCMRT-QGZVFWFLSA-N 50355500 CHEMBL1908394::US9695172, GSK461364 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355500&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 15983966 136959524 CHEMBL1908394 ZINC43154472 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50185828 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nc(cs3)-c3cccnc3)c2)CC1 InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32) WJEOLQLKVOPQFV-UHFFFAOYSA-N 50355495 CHEMBL1908391 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355495&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search G65 7TVX,5MQL,7JU7 10074640 136959519 63450 CHEMBL1908391 ZINC34177219 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50185833 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 540 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50186865 CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ RITAVMQDGBJQJZ-FMIVXFBMSA-N 25117 AG-013736::AXITINIB::N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide::US10464902, Axitinib::US9205078, Axitinib ::US9617222, Compound A Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25117&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 6450551 56374259 66910 5659 ZINC03816287 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50179340 CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+ JWNPDZNEKVCWMY-VQHVLOKHSA-N 50161957 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide::CHEMBL180022::HKI-272::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide::NERATINIB::US10822334, Compound Neratinib Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50161957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50161957&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9915743 104048227 CHEMBL180022 5686 ZINC03916214 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50181458 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Serine/threonine-protein kinase B-raf Homo sapiens 630 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50181459 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Serine/threonine-protein kinase B-raf Homo sapiens 1700 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50192310 COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3 XXJWYDDUDKYVKI-UHFFFAOYSA-N 50331096 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline::CHEMBL491473::Cediranib::US10464902, Cediranib::ZD-2171 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331096&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9933475 123110211 CHEMBL491473 DB04849 5664 ZINC03948085 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50192323 Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(Cc4ccccn4)CC3)c3ccccc23)c2ccccc12 InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39) AXRCEOKUDYDWLF-UHFFFAOYSA-N 50128285 3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indol-3-yl]-pyrrole-2,5-dione::CHEMBL300138 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50128285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50128285&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 176167 104020050 CHEMBL300138 5693 ZINC01494900 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50193622 CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 KGPGFQWBCSZGEL-ZDUSSCGKSA-N 25013 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol::GSK-690693::GSK690693::US10550114, Compound GSK690693 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25013&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search G93 3D0E,5U94 16725726 56374157 5196 ZINC34285211 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50195748 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50194709 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50194739 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50193830 C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 50306682 (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-(2,6-dichloro-3-fluorobenzyloxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine::CHEMBL601719::CRIZOTINIB::PF-2341066::US10370379, Crizotinib::US10543199, Compound Crizotinib::US10780082, Compound Crizotinib::US11059827, Compound Crizotinib::US11517561, Compound Crizotinib::US9126941, PF-2341066::US9199944, Crizotinib::US9226923, Crizotinib Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306682&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search VGH 2YFX,5AAA,5AAC,5AAB,4ANS,4ANQ,2XP2,2WGJ,3ZBF,4C9W,6IMZ 11626560 104161043 64310 CHEMBL601719 DB08700 4903 ZINC35902489 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50192788 Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1 InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1 BPNUQXPIQBZCMR-IBGZPJMESA-N 15138 5-indazolyl pyridine 11g::5-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-3-methyl-1H-indazole::A-674563::Biochemistry 469551 Compound 11::indazole-pyridine, 7 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15138&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search SS3 2UZT 11314340 46515449 DB08568 5655 ZINC16052569 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50192867 C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 UIARLYUEJFELEN-LROUJFHJSA-N 50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2V9 5WNJ,4OTG 126565 104162421 CHEMBL603469 5672 ZINC03781738 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50195097 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50194110 COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28- XZXHXSATPCNXJR-ZIADKAODSA-N 50026612 BIBF-1120::Nintedanib::US10981896, Compound Nintedanib::US11046672, Nintedanib::US11208381, Nintedanib::Vargatef Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026612&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search XIN 5MAF,6NEC,3C7Q,5TE0 9809715 277286638 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50192037 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50193158 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50211245 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 3 ChEMBL 10.1073/pnas.0707498104 10.7270/Q24X58QS 18077425 McDermott, U; Sharma, SV; Dowell, L; Greninger, P; Montagut, C; Lamb, J; Archibald, H; Raudales, R; Tam, A; Lee, D; Rothenberg, SM; Supko, JG; Sordella, R; Ulkus, LE; Iafrate, AJ; Maheswaran, S; Njauw, CN; Tsao, H; Drew, L; Hanke, JH; Ma, XJ; Erlander, MG; Gray, NS; Haber, DA; Settleman, J Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50227523 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Serine/threonine-protein kinase B-raf Homo sapiens 2300 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50227526 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Serine/threonine-protein kinase B-raf Homo sapiens 330 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50227537 Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) QHKYPYXTTXKZST-UHFFFAOYSA-N 13531 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190 Serine/threonine-protein kinase B-raf Homo sapiens 620 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13531&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 5353940 172097219 ZINC14951176 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50228663 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50228799 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Serine/threonine-protein kinase B-raf Homo sapiens 2700 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50227787 COCC(=O)NC\C=C\c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1 InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+ LLVZBTWPGQVVLW-SNAWJCMRSA-N 31340 2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridyl)oxy]anilino]quinazolin-6-yl]allyl]acetamide::2-methoxy-N-[(E)-3-[4-[[3-methyl-4-(6-methylpyridin-3-yl)oxy-phenyl]amino]quinazolin-6-yl]prop-2-enyl]ethanamide::CHEMBL483321::CP-724714::cid_9874913 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31340&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9874913 252615341 CHEMBL483321 ZINC03817105 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50229962 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) KDKUVYLMPJIGKA-UHFFFAOYSA-N 6866 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b::4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide::CHEMBL191003::JNJ-7706621::cid_5330790 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6866&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search SKE 5WIN,5USZ,5USY,5DR9,8B99,5OBR,6DRW,5DPV,5DR6,6P11,6P10,3AMA,4QMU,5DT0 5330790 8036422 CHEMBL191003 ZINC03938688 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50227892 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Serine/threonine-protein kinase B-raf Homo sapiens 530 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50226909 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50230064 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50230085 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50230104 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50227986 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50227995 NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCOc2c1)-c1ccccn1 InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26) FHYUGAJXYORMHI-UHFFFAOYSA-N 50110208 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(4-Benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::4-(5-(benzo[d][1,3]dioxol-5-yl)-4-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(5-benzo[1,3]dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::CHEMBL440084::SB-431542::cid_4521392 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110208&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 085 3TZM 4521392 104005054 CHEMBL440084 ZINC00603769 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50230138 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50230141 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236423 CC(C)N1CCN(CC(=O)Nc2cc(Oc3ccc4n(C)c(Nc5cc(ccc5F)C(F)(F)F)nc4c3)ccn2)CC1 InChI=1S/C29H31F4N7O2/c1-18(2)40-12-10-39(11-13-40)17-27(41)37-26-16-21(8-9-34-26)42-20-5-7-25-24(15-20)36-28(38(25)3)35-23-14-19(29(31,32)33)4-6-22(23)30/h4-9,14-16,18H,10-13,17H2,1-3H3,(H,35,36)(H,34,37,41) ZKNOTFQILSPCMY-UHFFFAOYSA-N 50026674 CHEMBL3335386 Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026674&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 59790182 103936261 CHEMBL3335386 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236424 CN1CCC(CC1)C(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cccc(c4)C(C)(C)C)nc3c2)ccn1 InChI=1S/C30H36N6O2/c1-30(2,3)21-7-6-8-22(17-21)32-29-33-25-18-23(9-10-26(25)36(29)5)38-24-11-14-31-27(19-24)34-28(37)20-12-15-35(4)16-13-20/h6-11,14,17-20H,12-13,15-16H2,1-5H3,(H,32,33)(H,31,34,37) UFZLFECVKGGBOA-UHFFFAOYSA-N 50026675 CHEMBL3335383 Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026675&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568606 103936262 CHEMBL3335383 ZINC13643648 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236425 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4ccc(cc4)C(F)(F)F)nc3c2)ccn1 InChI=1S/C22H18F3N5O2/c1-13(31)27-20-12-17(9-10-26-20)32-16-7-8-19-18(11-16)29-21(30(19)2)28-15-5-3-14(4-6-15)22(23,24)25/h3-12H,1-2H3,(H,28,29)(H,26,27,31) JSAGFLYKPJTEDK-UHFFFAOYSA-N 50026676 CHEMBL3335380 Serine/threonine-protein kinase B-raf Homo sapiens 50 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026676&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568477 103936263 CHEMBL3335380 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236426 CCc1ccc(Nc2nc3cc(Oc4ccnc(NC(C)=O)c4)ccc3n2C)cc1 InChI=1S/C23H23N5O2/c1-4-16-5-7-17(8-6-16)26-23-27-20-13-18(9-10-21(20)28(23)3)30-19-11-12-24-22(14-19)25-15(2)29/h5-14H,4H2,1-3H3,(H,26,27)(H,24,25,29) ZVLQDFZYWZFDCF-UHFFFAOYSA-N 50026677 CHEMBL3335377 Serine/threonine-protein kinase B-raf Homo sapiens 80 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026677&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568544 103936264 CHEMBL3335377 ZINC29338023 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236427 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cccc(OC(F)(F)F)c4)nc3c2)ccn1 InChI=1S/C22H18F3N5O3/c1-13(31)27-20-12-16(8-9-26-20)32-15-6-7-19-18(11-15)29-21(30(19)2)28-14-4-3-5-17(10-14)33-22(23,24)25/h3-12H,1-2H3,(H,28,29)(H,26,27,31) HGJCYDGGRLXLFD-UHFFFAOYSA-N 50026678 CHEMBL3335374 Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026678&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568471 103936265 CHEMBL3335374 ZINC29345285 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236428 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cccc(c4)C(C)(C)C)nc3c2)ccn1 InChI=1S/C25H27N5O2/c1-16(31)27-23-15-20(11-12-26-23)32-19-9-10-22-21(14-19)29-24(30(22)5)28-18-8-6-7-17(13-18)25(2,3)4/h6-15H,1-5H3,(H,28,29)(H,26,27,31) WSBZFFNSBMBYQA-UHFFFAOYSA-N 50026679 CHEMBL3335371 Serine/threonine-protein kinase B-raf Homo sapiens 40 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026679&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 59790029 103936266 CHEMBL3335371 ZINC29340348 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236429 CC(C)N1CCC(CC1)C(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cc(ccc4F)C(F)(F)F)nc3c2)ccn1 InChI=1S/C29H30F4N6O2/c1-17(2)39-12-9-18(10-13-39)27(40)37-26-16-21(8-11-34-26)41-20-5-7-25-24(15-20)36-28(38(25)3)35-23-14-19(29(31,32)33)4-6-22(23)30/h4-8,11,14-18H,9-10,12-13H2,1-3H3,(H,35,36)(H,34,37,40) NLHOWBQQPCBEPZ-UHFFFAOYSA-N 50026680 CHEMBL3335385 Serine/threonine-protein kinase B-raf Homo sapiens 2.0 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026680&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11433057 103936267 CHEMBL3335385 ZINC29330780 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236430 Cn1c(Nc2cccc(c2)C(C)(C)C)nc2cc(Oc3ccnc(NC(=O)C4CCNCC4)c3)ccc12 InChI=1S/C29H34N6O2/c1-29(2,3)20-6-5-7-21(16-20)32-28-33-24-17-22(8-9-25(24)35(28)4)37-23-12-15-31-26(18-23)34-27(36)19-10-13-30-14-11-19/h5-9,12,15-19,30H,10-11,13-14H2,1-4H3,(H,32,33)(H,31,34,36) NUDNMPOWFBWWRP-UHFFFAOYSA-N 50026681 CHEMBL3335382 Serine/threonine-protein kinase B-raf Homo sapiens 7.0 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026681&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568487 103936268 CHEMBL3335382 ZINC29343186 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236431 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4ccc(OC(F)(F)F)cc4)nc3c2)ccn1 InChI=1S/C22H18F3N5O3/c1-13(31)27-20-12-17(9-10-26-20)32-16-7-8-19-18(11-16)29-21(30(19)2)28-14-3-5-15(6-4-14)33-22(23,24)25/h3-12H,1-2H3,(H,28,29)(H,26,27,31) ZDPAPCJVVMWLKA-UHFFFAOYSA-N 50026683 CHEMBL3335379 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026683&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568562 103936270 CHEMBL3335379 ZINC29344121 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236432 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4ccc(cc4)C(C)(C)C)nc3c2)ccn1 InChI=1S/C25H27N5O2/c1-16(31)27-23-15-20(12-13-26-23)32-19-10-11-22-21(14-19)29-24(30(22)5)28-18-8-6-17(7-9-18)25(2,3)4/h6-15H,1-5H3,(H,28,29)(H,26,27,31) XHDADNXUBWKZIM-UHFFFAOYSA-N 50026684 CHEMBL3335376 Serine/threonine-protein kinase B-raf Homo sapiens 9.0 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026684&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568454 103936271 CHEMBL3335376 ZINC29328172 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236433 CC(C)c1cccc(Nc2nc3cc(Oc4ccnc(NC(C)=O)c4)ccc3n2C)c1 InChI=1S/C24H25N5O2/c1-15(2)17-6-5-7-18(12-17)27-24-28-21-13-19(8-9-22(21)29(24)4)31-20-10-11-25-23(14-20)26-16(3)30/h5-15H,1-4H3,(H,27,28)(H,25,26,30) CGKCRNMLFZNYKA-UHFFFAOYSA-N 50026685 CHEMBL3335373 Serine/threonine-protein kinase B-raf Homo sapiens <0.400000 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026685&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568594 103936272 CHEMBL3335373 ZINC29346890 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236436 CC(C)N1CCC(CC1)C(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cc(ccc4F)C(F)(F)F)nc3c2)ccn1 InChI=1S/C29H30F4N6O2/c1-17(2)39-12-9-18(10-13-39)27(40)37-26-16-21(8-11-34-26)41-20-5-7-25-24(15-20)36-28(38(25)3)35-23-14-19(29(31,32)33)4-6-22(23)30/h4-8,11,14-18H,9-10,12-13H2,1-3H3,(H,35,36)(H,34,37,40) NLHOWBQQPCBEPZ-UHFFFAOYSA-N 50026680 CHEMBL3335385 Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026680&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11433057 103936267 CHEMBL3335385 ZINC29330780 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236437 Cn1c(Nc2cccc(c2)C(C)(C)C)nc2cc(Oc3ccnc(NC(=O)C4CCNCC4)c3)ccc12 InChI=1S/C29H34N6O2/c1-29(2,3)20-6-5-7-21(16-20)32-28-33-24-17-22(8-9-25(24)35(28)4)37-23-12-15-31-26(18-23)34-27(36)19-10-13-30-14-11-19/h5-9,12,15-19,30H,10-11,13-14H2,1-4H3,(H,32,33)(H,31,34,36) NUDNMPOWFBWWRP-UHFFFAOYSA-N 50026681 CHEMBL3335382 Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026681&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568487 103936268 CHEMBL3335382 ZINC29343186 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236438 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4ccc(OC(F)(F)F)cc4)nc3c2)ccn1 InChI=1S/C22H18F3N5O3/c1-13(31)27-20-12-17(9-10-26-20)32-16-7-8-19-18(11-16)29-21(30(19)2)28-14-3-5-15(6-4-14)33-22(23,24)25/h3-12H,1-2H3,(H,28,29)(H,26,27,31) ZDPAPCJVVMWLKA-UHFFFAOYSA-N 50026683 CHEMBL3335379 Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026683&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568562 103936270 CHEMBL3335379 ZINC29344121 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236439 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4ccc(cc4)C(C)(C)C)nc3c2)ccn1 InChI=1S/C25H27N5O2/c1-16(31)27-23-15-20(12-13-26-23)32-19-10-11-22-21(14-19)29-24(30(22)5)28-18-8-6-17(7-9-18)25(2,3)4/h6-15H,1-5H3,(H,28,29)(H,26,27,31) XHDADNXUBWKZIM-UHFFFAOYSA-N 50026684 CHEMBL3335376 Serine/threonine-protein kinase B-raf Homo sapiens 50 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026684&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568454 103936271 CHEMBL3335376 ZINC29328172 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236440 CC(C)c1cccc(Nc2nc3cc(Oc4ccnc(NC(C)=O)c4)ccc3n2C)c1 InChI=1S/C24H25N5O2/c1-15(2)17-6-5-7-18(12-17)27-24-28-21-13-19(8-9-22(21)29(24)4)31-20-10-11-25-23(14-20)26-16(3)30/h5-15H,1-4H3,(H,27,28)(H,25,26,30) CGKCRNMLFZNYKA-UHFFFAOYSA-N 50026685 CHEMBL3335373 Serine/threonine-protein kinase B-raf Homo sapiens 50 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026685&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568594 103936272 CHEMBL3335373 ZINC29346890 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236441 CCN1CCN(CC(=O)Nc2cc(Oc3ccc4n(C)c(Nc5cc(ccc5F)C(F)(F)F)nc4c3)ccn2)CC1 InChI=1S/C28H29F4N7O2/c1-3-38-10-12-39(13-11-38)17-26(40)36-25-16-20(8-9-33-25)41-19-5-7-24-23(15-19)35-27(37(24)2)34-22-14-18(28(30,31)32)4-6-21(22)29/h4-9,14-16H,3,10-13,17H2,1-2H3,(H,34,35)(H,33,36,40) CXXTWUWDVIYTID-UHFFFAOYSA-N 50026673 CHEMBL3335387 Serine/threonine-protein kinase B-raf Homo sapiens 6.0 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11387552 103936260 CHEMBL3335387 ZINC29334780 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236442 CC(C)N1CCC(CC1)C(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cccc(c4)C(C)(C)C)nc3c2)ccn1 InChI=1S/C32H40N6O2/c1-21(2)38-16-13-22(14-17-38)30(39)36-29-20-26(12-15-33-29)40-25-10-11-28-27(19-25)35-31(37(28)6)34-24-9-7-8-23(18-24)32(3,4)5/h7-12,15,18-22H,13-14,16-17H2,1-6H3,(H,34,35)(H,33,36,39) XTXLNRXRPGKTRM-UHFFFAOYSA-N 50026686 CHEMBL3335384 Serine/threonine-protein kinase B-raf Homo sapiens 20 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026686&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568472 103936273 CHEMBL3335384 ZINC29339118 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236443 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cc(ccc4F)C(F)(F)F)nc3c2)ccn1 InChI=1S/C22H17F4N5O2/c1-12(32)28-20-11-15(7-8-27-20)33-14-4-6-19-18(10-14)30-21(31(19)2)29-17-9-13(22(24,25)26)3-5-16(17)23/h3-11H,1-2H3,(H,29,30)(H,27,28,32) ZWEATXDGZUTATR-UHFFFAOYSA-N 50026692 CHEMBL3335381 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026692&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11476663 103936279 CHEMBL3335381 ZINC29392711 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236444 CC(C)c1ccc(Nc2nc3cc(Oc4ccnc(NC(C)=O)c4)ccc3n2C)cc1 InChI=1S/C24H25N5O2/c1-15(2)17-5-7-18(8-6-17)27-24-28-21-13-19(9-10-22(21)29(24)4)31-20-11-12-25-23(14-20)26-16(3)30/h5-15H,1-4H3,(H,27,28)(H,25,26,30) WLEYVDRNBJKUAC-UHFFFAOYSA-N 50026693 CHEMBL3335378 Serine/threonine-protein kinase B-raf Homo sapiens 4.0 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026693&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568636 103936280 CHEMBL3335378 ZINC01611849 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236445 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cccc(c4)C(F)(F)F)nc3c2)ccn1 InChI=1S/C22H18F3N5O2/c1-13(31)27-20-12-17(8-9-26-20)32-16-6-7-19-18(11-16)29-21(30(19)2)28-15-5-3-4-14(10-15)22(23,24)25/h3-12H,1-2H3,(H,28,29)(H,26,27,31) CUPDAZFMKZKJEG-UHFFFAOYSA-N 50026694 CHEMBL3335375 Serine/threonine-protein kinase B-raf Homo sapiens 3.0 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026694&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568638 103936281 CHEMBL3335375 ZINC29392756 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236446 CCc1cccc(Nc2nc3cc(Oc4ccnc(NC(C)=O)c4)ccc3n2C)c1 InChI=1S/C23H23N5O2/c1-4-16-6-5-7-17(12-16)26-23-27-20-13-18(8-9-21(20)28(23)3)30-19-10-11-24-22(14-19)25-15(2)29/h5-14H,4H2,1-3H3,(H,26,27)(H,24,25,29) XWYAQRNOHRWIKN-UHFFFAOYSA-N 50026695 CHEMBL3335372 Serine/threonine-protein kinase B-raf Homo sapiens <0.400000 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026695&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568659 103936282 CHEMBL3335372 ZINC29392717 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236449 CCN1CCN(CC(=O)Nc2cc(Oc3ccc4n(C)c(Nc5cc(ccc5F)C(F)(F)F)nc4c3)ccn2)CC1 InChI=1S/C28H29F4N7O2/c1-3-38-10-12-39(13-11-38)17-26(40)36-25-16-20(8-9-33-25)41-19-5-7-24-23(15-19)35-27(37(24)2)34-22-14-18(28(30,31)32)4-6-21(22)29/h4-9,14-16H,3,10-13,17H2,1-2H3,(H,34,35)(H,33,36,40) CXXTWUWDVIYTID-UHFFFAOYSA-N 50026673 CHEMBL3335387 Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11387552 103936260 CHEMBL3335387 ZINC29334780 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236450 CC(C)N1CCC(CC1)C(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cccc(c4)C(C)(C)C)nc3c2)ccn1 InChI=1S/C32H40N6O2/c1-21(2)38-16-13-22(14-17-38)30(39)36-29-20-26(12-15-33-29)40-25-10-11-28-27(19-25)35-31(37(28)6)34-24-9-7-8-23(18-24)32(3,4)5/h7-12,15,18-22H,13-14,16-17H2,1-6H3,(H,34,35)(H,33,36,39) XTXLNRXRPGKTRM-UHFFFAOYSA-N 50026686 CHEMBL3335384 Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026686&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568472 103936273 CHEMBL3335384 ZINC29339118 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236451 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cc(ccc4F)C(F)(F)F)nc3c2)ccn1 InChI=1S/C22H17F4N5O2/c1-12(32)28-20-11-15(7-8-27-20)33-14-4-6-19-18(10-14)30-21(31(19)2)29-17-9-13(22(24,25)26)3-5-16(17)23/h3-11H,1-2H3,(H,29,30)(H,27,28,32) ZWEATXDGZUTATR-UHFFFAOYSA-N 50026692 CHEMBL3335381 Serine/threonine-protein kinase B-raf Homo sapiens 90 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026692&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11476663 103936279 CHEMBL3335381 ZINC29392711 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236452 CC(C)c1ccc(Nc2nc3cc(Oc4ccnc(NC(C)=O)c4)ccc3n2C)cc1 InChI=1S/C24H25N5O2/c1-15(2)17-5-7-18(8-6-17)27-24-28-21-13-19(9-10-22(21)29(24)4)31-20-11-12-25-23(14-20)26-16(3)30/h5-15H,1-4H3,(H,27,28)(H,25,26,30) WLEYVDRNBJKUAC-UHFFFAOYSA-N 50026693 CHEMBL3335378 Serine/threonine-protein kinase B-raf Homo sapiens 90 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026693&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568636 103936280 CHEMBL3335378 ZINC01611849 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236453 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cccc(c4)C(F)(F)F)nc3c2)ccn1 InChI=1S/C22H18F3N5O2/c1-13(31)27-20-12-17(8-9-26-20)32-16-6-7-19-18(11-16)29-21(30(19)2)28-15-5-3-4-14(10-15)22(23,24)25/h3-12H,1-2H3,(H,28,29)(H,26,27,31) CUPDAZFMKZKJEG-UHFFFAOYSA-N 50026694 CHEMBL3335375 Serine/threonine-protein kinase B-raf Homo sapiens 400 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026694&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568638 103936281 CHEMBL3335375 ZINC29392756 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236454 CCc1cccc(Nc2nc3cc(Oc4ccnc(NC(C)=O)c4)ccc3n2C)c1 InChI=1S/C23H23N5O2/c1-4-16-6-5-7-17(12-16)26-23-27-20-13-18(8-9-21(20)28(23)3)30-19-10-11-24-22(14-19)25-15(2)29/h5-14H,4H2,1-3H3,(H,26,27)(H,24,25,29) XWYAQRNOHRWIKN-UHFFFAOYSA-N 50026695 CHEMBL3335372 Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026695&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568659 103936282 CHEMBL3335372 ZINC29392717 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236455 CC(C)N1CCN(CC(=O)Nc2cc(Oc3ccc4n(C)c(Nc5cc(ccc5F)C(F)(F)F)nc4c3)ccn2)CC1 InChI=1S/C29H31F4N7O2/c1-18(2)40-12-10-39(11-13-40)17-27(41)37-26-16-21(8-9-34-26)42-20-5-7-25-24(15-20)36-28(38(25)3)35-23-14-19(29(31,32)33)4-6-22(23)30/h4-9,14-16,18H,10-13,17H2,1-3H3,(H,35,36)(H,34,37,41) ZKNOTFQILSPCMY-UHFFFAOYSA-N 50026674 CHEMBL3335386 Serine/threonine-protein kinase B-raf Homo sapiens 6.0 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026674&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 59790182 103936261 CHEMBL3335386 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236456 CN1CCC(CC1)C(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cccc(c4)C(C)(C)C)nc3c2)ccn1 InChI=1S/C30H36N6O2/c1-30(2,3)21-7-6-8-22(17-21)32-29-33-25-18-23(9-10-26(25)36(29)5)38-24-11-14-31-27(19-24)34-28(37)20-12-15-35(4)16-13-20/h6-11,14,17-20H,12-13,15-16H2,1-5H3,(H,32,33)(H,31,34,37) UFZLFECVKGGBOA-UHFFFAOYSA-N 50026675 CHEMBL3335383 Serine/threonine-protein kinase B-raf Homo sapiens 10.0 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026675&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568606 103936262 CHEMBL3335383 ZINC13643648 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50229128 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236457 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4ccc(cc4)C(F)(F)F)nc3c2)ccn1 InChI=1S/C22H18F3N5O2/c1-13(31)27-20-12-17(9-10-26-20)32-16-7-8-19-18(11-16)29-21(30(19)2)28-15-5-3-14(4-6-15)22(23,24)25/h3-12H,1-2H3,(H,28,29)(H,26,27,31) JSAGFLYKPJTEDK-UHFFFAOYSA-N 50026676 CHEMBL3335380 Serine/threonine-protein kinase B-raf Homo sapiens 4.0 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026676&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568477 103936263 CHEMBL3335380 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236458 CCc1ccc(Nc2nc3cc(Oc4ccnc(NC(C)=O)c4)ccc3n2C)cc1 InChI=1S/C23H23N5O2/c1-4-16-5-7-17(8-6-16)26-23-27-20-13-18(9-10-21(20)28(23)3)30-19-11-12-24-22(14-19)25-15(2)29/h5-14H,4H2,1-3H3,(H,26,27)(H,24,25,29) ZVLQDFZYWZFDCF-UHFFFAOYSA-N 50026677 CHEMBL3335377 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026677&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568544 103936264 CHEMBL3335377 ZINC29338023 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236459 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cccc(OC(F)(F)F)c4)nc3c2)ccn1 InChI=1S/C22H18F3N5O3/c1-13(31)27-20-12-16(8-9-26-20)32-15-6-7-19-18(11-15)29-21(30(19)2)28-14-4-3-5-17(10-14)33-22(23,24)25/h3-12H,1-2H3,(H,28,29)(H,26,27,31) HGJCYDGGRLXLFD-UHFFFAOYSA-N 50026678 CHEMBL3335374 Serine/threonine-protein kinase B-raf Homo sapiens 0.400000 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026678&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57568471 103936265 CHEMBL3335374 ZINC29345285 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50236460 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cccc(c4)C(C)(C)C)nc3c2)ccn1 InChI=1S/C25H27N5O2/c1-16(31)27-23-15-20(11-12-26-23)32-19-9-10-22-21(14-19)29-24(30(22)5)28-18-8-6-7-17(13-18)25(2,3)4/h6-15H,1-5H3,(H,28,29)(H,26,27,31) WSBZFFNSBMBYQA-UHFFFAOYSA-N 50026679 CHEMBL3335371 Serine/threonine-protein kinase B-raf Homo sapiens 3.0 ChEMBL 10.1021/ml5002272 10.7270/Q2RN39FP 25221654 Subramanian, S; Costales, A; Williams, TE; Levine, B; McBride, CM; Poon, D; Amiri, P; Renhowe, PA; Shafer, CM; Stuart, D; Verhagen, J; Ramurthy, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026679&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 59790029 103936266 CHEMBL3335371 ZINC29340348 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50230283 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50230292 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50229216 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50229217 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Serine/threonine-protein kinase B-raf Homo sapiens 500 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50228254 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50230382 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50230434 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50228328 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50230448 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50230500 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50227388 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50228376 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50228399 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Serine/threonine-protein kinase B-raf Homo sapiens 430 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50228402 CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+ WVUNYSQLFKLYNI-AATRIKPKSA-N 31090 (E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-3-cyano-7-ethoxy-quinolin-6-yl]-4-(dimethylamino)but-2-enamide::EKB-569::Pelitinib::cid_6445562 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31090&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 93J 7AXM,5VCW 6445562 252615337 38927 ZINC00602803 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50228427 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 540 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50227409 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50228483 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50229546 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50241214 OCCn1cc(c(n1)-c1ccncc1)-c1ccc2\C(CCc2c1)=N\O InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,24-25H,2,4,9-10H2/b22-18+ DEZZLWQELQORIU-RELWKKBWSA-N 50029085 CHEBI:83405::CHEMBL525191::GDC-0879 Serine/threonine-protein kinase B-raf Homo sapiens 0.130000 ChEMBL 10.1016/j.bmc.2014.08.029 10.7270/Q2RB7658 25267006 Wang, SF; Zhu, YL; Zhu, PT; Makawana, JA; Zhang, YL; Zhao, MY; Lv, PC; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029085&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 29L 6U2H,4MNF,7SHV 11717001 313065644 CHEMBL525191 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50227476 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50227509 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Serine/threonine-protein kinase B-raf Homo sapiens 280 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50227512 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Serine/threonine-protein kinase B-raf Homo sapiens 130 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50229596 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50229619 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258101 Fc1ccc(NS(=O)(=O)c2ccoc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H13F2N7O3S/c21-13-3-4-14(29-33(30,31)11-5-7-32-8-11)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-10,29H,(H,23,28)(H,24,25,26,27) ACIXGVIVJZJKNT-UHFFFAOYSA-N 50038473 CHEMBL3354844::US9216981, 18 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038473&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 56965341 313067299 CHEMBL3354844 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258102 FC(F)(F)c1cc(NC(=O)Nc2cccc(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)ccc1Cl InChI=1S/C24H16ClF3N8O/c25-18-7-6-15(10-17(18)24(26,27)28)36-23(37)35-14-4-1-3-13(9-14)34-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,34)(H2,35,36,37)(H,30,31,32,33) OPIIBVGNKWURBU-UHFFFAOYSA-N 50038474 CHEMBL3354377 Serine/threonine-protein kinase B-raf Homo sapiens 12 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038474&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118720154 313067300 CHEMBL3354377 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258103 Cc1ccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C25H18ClF3N8O/c1-13-4-5-15(36-24(38)35-14-6-7-18(26)17(9-14)25(27,28)29)10-19(13)37-22-16(3-2-8-30-22)20-21-23(33-11-31-20)34-12-32-21/h2-12H,1H3,(H,30,37)(H2,35,36,38)(H,31,32,33,34) STTDIXQHJWIPKY-UHFFFAOYSA-N 50038475 CHEMBL3354378 Serine/threonine-protein kinase B-raf Homo sapiens 4.2 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038475&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118720155 313067301 CHEMBL3354378 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258104 FC(F)(F)c1cc(NC(=O)c2cccc(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)ccc1Cl InChI=1S/C24H15ClF3N7O/c25-18-7-6-15(10-17(18)24(26,27)28)35-23(36)13-3-1-4-14(9-13)34-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,34)(H,35,36)(H,30,31,32,33) YPZDKTXOVIBNTQ-UHFFFAOYSA-N 50038476 CHEMBL3354379 Serine/threonine-protein kinase B-raf Homo sapiens 14 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038476&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118720156 313067302 CHEMBL3354379 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258105 Cc1ccc(cc1Nc1ncccc1-c1ncnc2[nH]cnc12)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F InChI=1S/C25H17ClF3N7O/c1-13-4-5-14(24(37)35-15-6-7-18(26)17(10-15)25(27,28)29)9-19(13)36-22-16(3-2-8-30-22)20-21-23(33-11-31-20)34-12-32-21/h2-12H,1H3,(H,30,36)(H,35,37)(H,31,32,33,34) WQRFPBBFVQEFCU-UHFFFAOYSA-N 50038477 CHEMBL3354380 Serine/threonine-protein kinase B-raf Homo sapiens 3.2 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038477&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73330891 313067303 CHEMBL3354380 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258106 Cc1ccc(cc1Nc1ncccc1-c1ncnc2[nH]cnc12)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C25H18F3N7O/c1-14-7-8-15(24(36)34-17-5-2-4-16(11-17)25(26,27)28)10-19(14)35-22-18(6-3-9-29-22)20-21-23(32-12-30-20)33-13-31-21/h2-13H,1H3,(H,29,35)(H,34,36)(H,30,31,32,33) VEAGMIRFBPBOSJ-UHFFFAOYSA-N 50038478 CHEMBL3354381 Serine/threonine-protein kinase B-raf Homo sapiens 2.2 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038478&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331182 313067304 CHEMBL3354381 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258107 CC(C)c1cccc(NC(=O)c2ccc(C)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)c1 InChI=1S/C27H25N7O/c1-16(2)18-6-4-7-20(12-18)33-27(35)19-10-9-17(3)22(13-19)34-25-21(8-5-11-28-25)23-24-26(31-14-29-23)32-15-30-24/h4-16H,1-3H3,(H,28,34)(H,33,35)(H,29,30,31,32) VCGDGUIMJHDFOR-UHFFFAOYSA-N 50038479 CHEMBL3354382 Serine/threonine-protein kinase B-raf Homo sapiens 1.7 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038479&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73330894 313067305 CHEMBL3354382 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258108 Cc1ccc(cc1Nc1ncccc1-c1ncnc2[nH]cnc12)C(=O)Nc1cccc(c1)C#N InChI=1S/C25H18N8O/c1-15-7-8-17(25(34)32-18-5-2-4-16(10-18)12-26)11-20(15)33-23-19(6-3-9-27-23)21-22-24(30-13-28-21)31-14-29-22/h2-11,13-14H,1H3,(H,27,33)(H,32,34)(H,28,29,30,31) SKZJSARUKPUIFQ-UHFFFAOYSA-N 50038480 CHEMBL3352837 Serine/threonine-protein kinase B-raf Homo sapiens 0.717000 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038480&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331037 313067306 CHEMBL3352837 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258109 Cc1ccc(cc1Nc1ncccc1-c1ncnc2[nH]cnc12)C(=O)Nc1cccc(F)c1 InChI=1S/C24H18FN7O/c1-14-7-8-15(24(33)31-17-5-2-4-16(25)11-17)10-19(14)32-22-18(6-3-9-26-22)20-21-23(29-12-27-20)30-13-28-21/h2-13H,1H3,(H,26,32)(H,31,33)(H,27,28,29,30) BJRDHINFCGGDPH-UHFFFAOYSA-N 50038481 CHEMBL3354383 Serine/threonine-protein kinase B-raf Homo sapiens 1.0 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038481&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331038 313067307 CHEMBL3354383 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258110 Cc1cc(NC(=O)c2ccc(C)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)ccc1Cl InChI=1S/C25H20ClN7O/c1-14-5-6-16(25(34)32-17-7-8-19(26)15(2)10-17)11-20(14)33-23-18(4-3-9-27-23)21-22-24(30-12-28-21)31-13-29-22/h3-13H,1-2H3,(H,27,33)(H,32,34)(H,28,29,30,31) CJHJDHMTGXCQIJ-UHFFFAOYSA-N 50038482 CHEMBL3354384 Serine/threonine-protein kinase B-raf Homo sapiens 1.4 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038482&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331039 313067308 CHEMBL3354384 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258111 Cc1ccc(cc1Nc1ncccc1-c1ncnc2[nH]cnc12)C(=O)Nc1cccc(Cl)c1 InChI=1S/C24H18ClN7O/c1-14-7-8-15(24(33)31-17-5-2-4-16(25)11-17)10-19(14)32-22-18(6-3-9-26-22)20-21-23(29-12-27-20)30-13-28-21/h2-13H,1H3,(H,26,32)(H,31,33)(H,27,28,29,30) CBWHWLUSSFEGLA-UHFFFAOYSA-N 50038483 CHEMBL3354385 Serine/threonine-protein kinase B-raf Homo sapiens 1.3 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331041 313067309 CHEMBL3354385 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258112 Cc1ccc(cc1Nc1ncccc1-c1ncnc2[nH]cnc12)C(=O)Nc1ccc(Cl)c(Br)c1 InChI=1S/C24H17BrClN7O/c1-13-4-5-14(24(34)32-15-6-7-18(26)17(25)10-15)9-19(13)33-22-16(3-2-8-27-22)20-21-23(30-11-28-20)31-12-29-21/h2-12H,1H3,(H,27,33)(H,32,34)(H,28,29,30,31) DVMPNCIXUVJTKE-UHFFFAOYSA-N 50038484 CHEMBL3354386 Serine/threonine-protein kinase B-raf Homo sapiens 3.6 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038484&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331183 313067310 CHEMBL3354386 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258113 Cc1ccc(cc1Nc1ncccc1-c1ncnc2[nH]cnc12)C(=O)Nc1ccc(cc1)C(F)(F)F InChI=1S/C25H18F3N7O/c1-14-4-5-15(24(36)34-17-8-6-16(7-9-17)25(26,27)28)11-19(14)35-22-18(3-2-10-29-22)20-21-23(32-12-30-20)33-13-31-21/h2-13H,1H3,(H,29,35)(H,34,36)(H,30,31,32,33) QEJNTUKPRFPRBK-UHFFFAOYSA-N 50038485 CHEMBL3354387 Serine/threonine-protein kinase B-raf Homo sapiens 1.5 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038485&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331184 313067311 CHEMBL3354387 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258114 FC(F)(F)c1cc(NC(=O)c2ccc(Cl)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)ccc1Cl InChI=1S/C24H14Cl2F3N7O/c25-16-6-4-13(9-15(16)24(27,28)29)35-23(37)12-3-5-17(26)18(8-12)36-21-14(2-1-7-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,36)(H,35,37)(H,31,32,33,34) RDALVTOYVIWLPR-UHFFFAOYSA-N 50038486 CHEMBL3354388 Serine/threonine-protein kinase B-raf Homo sapiens 11 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038486&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118720157 313067312 CHEMBL3354388 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258115 FC(F)(F)c1cccc(NC(=O)c2ccc(Cl)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)c1 InChI=1S/C24H15ClF3N7O/c25-17-7-6-13(23(36)34-15-4-1-3-14(10-15)24(26,27)28)9-18(17)35-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,35)(H,34,36)(H,30,31,32,33) KEWAGIYMGOBSQD-UHFFFAOYSA-N 50038487 CHEMBL3354389 Serine/threonine-protein kinase B-raf Homo sapiens 2.8 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038487&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73330892 313067313 CHEMBL3354389 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258116 CC(C)c1cccc(NC(=O)c2ccc(Cl)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)c1 InChI=1S/C26H22ClN7O/c1-15(2)16-5-3-6-18(11-16)33-26(35)17-8-9-20(27)21(12-17)34-24-19(7-4-10-28-24)22-23-25(31-13-29-22)32-14-30-23/h3-15H,1-2H3,(H,28,34)(H,33,35)(H,29,30,31,32) VINDXEHBECAULT-UHFFFAOYSA-N 50038488 CHEMBL3354390 Serine/threonine-protein kinase B-raf Homo sapiens 8.1 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038488&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331186 313067314 CHEMBL3354390 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258117 Clc1ccc(NC(=O)c2ccc(Cl)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)cc1Cl InChI=1S/C23H14Cl3N7O/c24-15-6-4-13(9-17(15)26)32-23(34)12-3-5-16(25)18(8-12)33-21-14(2-1-7-27-21)19-20-22(30-10-28-19)31-11-29-20/h1-11H,(H,27,33)(H,32,34)(H,28,29,30,31) SMPZSQIXFODPDJ-UHFFFAOYSA-N 50038489 CHEMBL3354391 Serine/threonine-protein kinase B-raf Homo sapiens 1.6 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038489&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331040 313067315 CHEMBL3354391 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258118 Fc1ccc(cc1Nc1ncccc1-c1ncnc2[nH]cnc12)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F InChI=1S/C24H14ClF4N7O/c25-16-5-4-13(9-15(16)24(27,28)29)35-23(37)12-3-6-17(26)18(8-12)36-21-14(2-1-7-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,36)(H,35,37)(H,31,32,33,34) PQJNDAWDFNEYOV-UHFFFAOYSA-N 50038490 CHEMBL3354392 Serine/threonine-protein kinase B-raf Homo sapiens 4.8 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038490&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331185 312697419 CHEMBL3354392 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258119 FC(F)(F)c1cc(ccc1Cl)C(=O)Nc1cccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c1 InChI=1S/C24H15ClF3N7O/c25-18-7-6-13(9-17(18)24(26,27)28)23(36)35-15-4-1-3-14(10-15)34-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,34)(H,35,36)(H,30,31,32,33) VJCGQSIIVIDIRZ-UHFFFAOYSA-N 50038491 CHEMBL3354393 Serine/threonine-protein kinase B-raf Homo sapiens 3.0 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038491&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331464 313067316 CHEMBL3354393 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258120 Cc1ccc(NC(=O)c2ccc(Cl)c(c2)C(F)(F)F)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C25H17ClF3N7O/c1-13-4-6-15(35-24(37)14-5-7-18(26)17(9-14)25(27,28)29)10-19(13)36-22-16(3-2-8-30-22)20-21-23(33-11-31-20)34-12-32-21/h2-12H,1H3,(H,30,36)(H,35,37)(H,31,32,33,34) QMMVAJULMXHTAH-UHFFFAOYSA-N 50038492 CHEMBL3354394 Serine/threonine-protein kinase B-raf Homo sapiens 2.7 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038492&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331324 313067317 CHEMBL3354394 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258121 Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C25H18F3N7O/c1-14-7-8-17(34-24(36)15-4-2-5-16(10-15)25(26,27)28)11-19(14)35-22-18(6-3-9-29-22)20-21-23(32-12-30-20)33-13-31-21/h2-13H,1H3,(H,29,35)(H,34,36)(H,30,31,32,33) ANPGGCNBNSJETG-UHFFFAOYSA-N 50038493 CHEMBL3354835::US10844062, Example 71 Serine/threonine-protein kinase B-raf Homo sapiens 2.5 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038493&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331323 313067318 CHEMBL3354835 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258122 Cc1ccc(NC(=O)c2cccc(c2)C#N)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C25H18N8O/c1-15-7-8-18(32-25(34)17-5-2-4-16(10-17)12-26)11-20(15)33-23-19(6-3-9-27-23)21-22-24(30-13-28-21)31-14-29-22/h2-11,13-14H,1H3,(H,27,33)(H,32,34)(H,28,29,30,31) GVVVKNSBSBPROI-UHFFFAOYSA-N 50038494 CHEMBL3354836 Serine/threonine-protein kinase B-raf Homo sapiens 0.669000 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038494&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118720457 313067319 CHEMBL3354836 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258123 Cc1cc(ccc1Cl)C(=O)Nc1ccc(C)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1 InChI=1S/C25H20ClN7O/c1-14-5-7-17(32-25(34)16-6-8-19(26)15(2)10-16)11-20(14)33-23-18(4-3-9-27-23)21-22-24(30-12-28-21)31-13-29-22/h3-13H,1-2H3,(H,27,33)(H,32,34)(H,28,29,30,31) GHLGXWRGXAEXSW-UHFFFAOYSA-N 50038495 CHEMBL3354837 Serine/threonine-protein kinase B-raf Homo sapiens 2.6 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038495&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118720458 313067320 CHEMBL3354837 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258124 Cc1ccc(NC(=O)c2cccc(Cl)c2)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C24H18ClN7O/c1-14-7-8-17(31-24(33)15-4-2-5-16(25)10-15)11-19(14)32-22-18(6-3-9-26-22)20-21-23(29-12-27-20)30-13-28-21/h2-13H,1H3,(H,26,32)(H,31,33)(H,27,28,29,30) LJXUQKGKTYYFSC-UHFFFAOYSA-N 50038496 CHEMBL3354838 Serine/threonine-protein kinase B-raf Homo sapiens 1.8 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038496&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118720459 313067321 CHEMBL3354838 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258125 COc1cccc(c1)C(=O)Nc1ccc(C)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1 InChI=1S/C25H21N7O2/c1-15-8-9-17(31-25(33)16-5-3-6-18(11-16)34-2)12-20(15)32-23-19(7-4-10-26-23)21-22-24(29-13-27-21)30-14-28-22/h3-14H,1-2H3,(H,26,32)(H,31,33)(H,27,28,29,30) GJORKFGZQPJBPU-UHFFFAOYSA-N 50038497 CHEMBL3354839 Serine/threonine-protein kinase B-raf Homo sapiens 1.2 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038497&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73330893 313067322 CHEMBL3354839 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258126 CN(C)c1cccc(c1)C(=O)Nc1ccc(C)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1 InChI=1S/C26H24N8O/c1-16-9-10-18(32-26(35)17-6-4-7-19(12-17)34(2)3)13-21(16)33-24-20(8-5-11-27-24)22-23-25(30-14-28-22)31-15-29-23/h4-15H,1-3H3,(H,27,33)(H,32,35)(H,28,29,30,31) UHZCQUJTKLRWKF-UHFFFAOYSA-N 50038498 CHEMBL3354840 Serine/threonine-protein kinase B-raf Homo sapiens 0.790000 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038498&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331320 313067323 CHEMBL3354840 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258127 CC(C)c1cccc(NC(=O)c2ccc(C)c(Nc3ncccc3-c3ncnc4n(C)cnc34)c2)c1 InChI=1S/C28H27N7O/c1-17(2)19-7-5-8-21(13-19)33-28(36)20-11-10-18(3)23(14-20)34-26-22(9-6-12-29-26)24-25-27(31-15-30-24)35(4)16-32-25/h5-17H,1-4H3,(H,29,34)(H,33,36) CTNLHENHAALKMX-UHFFFAOYSA-N 50038597 CHEMBL3354841 Serine/threonine-protein kinase B-raf Homo sapiens 7.4 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038597&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118720460 103945897 CHEMBL3354841 ZINC35565131 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258128 O=C(Nc1cccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c1)C1CC1 InChI=1S/C20H17N7O/c28-20(12-6-7-12)27-14-4-1-3-13(9-14)26-18-15(5-2-8-21-18)16-17-19(24-10-22-16)25-11-23-17/h1-5,8-12H,6-7H2,(H,21,26)(H,27,28)(H,22,23,24,25) UTQHRNZQNHJNAJ-UHFFFAOYSA-N 50038606 CHEMBL3354842 Serine/threonine-protein kinase B-raf Homo sapiens 471 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038606&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118720461 313067324 CHEMBL3354842 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258129 CC(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1Cl InChI=1S/C18H14ClN7O/c1-10(27)25-14-7-11(4-5-13(14)19)26-17-12(3-2-6-20-17)15-16-18(23-8-21-15)24-9-22-16/h2-9H,1H3,(H,20,26)(H,25,27)(H,21,22,23,24) JEUUUSWGGIADJD-UHFFFAOYSA-N 50038607 CHEMBL3354843 Serine/threonine-protein kinase B-raf Homo sapiens 6430 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038607&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118720462 313067325 CHEMBL3354843 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258130 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 26 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258131 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 23 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258132 Cc1cc(NC(=O)c2ccc(C)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)ccc1Cl InChI=1S/C25H20ClN7O/c1-14-5-6-16(25(34)32-17-7-8-19(26)15(2)10-17)11-20(14)33-23-18(4-3-9-27-23)21-22-24(30-12-28-21)31-13-29-22/h3-13H,1-2H3,(H,27,33)(H,32,34)(H,28,29,30,31) CJHJDHMTGXCQIJ-UHFFFAOYSA-N 50038482 CHEMBL3354384 Serine/threonine-protein kinase B-raf Homo sapiens 16 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038482&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331039 313067308 CHEMBL3354384 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258133 CN(C)c1cccc(c1)C(=O)Nc1ccc(C)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1 InChI=1S/C26H24N8O/c1-16-9-10-18(32-26(35)17-6-4-7-19(12-17)34(2)3)13-21(16)33-24-20(8-5-11-27-24)22-23-25(30-14-28-22)31-15-29-23/h4-15H,1-3H3,(H,27,33)(H,32,35)(H,28,29,30,31) UHZCQUJTKLRWKF-UHFFFAOYSA-N 50038498 CHEMBL3354840 Serine/threonine-protein kinase B-raf Homo sapiens 5.1 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038498&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331320 313067323 CHEMBL3354840 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258134 Cc1ccc(cc1Nc1ncccc1-c1ncnc2[nH]cnc12)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C25H18F3N7O/c1-14-7-8-15(24(36)34-17-5-2-4-16(11-17)25(26,27)28)10-19(14)35-22-18(6-3-9-29-22)20-21-23(32-12-30-20)33-13-31-21/h2-13H,1H3,(H,29,35)(H,34,36)(H,30,31,32,33) VEAGMIRFBPBOSJ-UHFFFAOYSA-N 50038478 CHEMBL3354381 Serine/threonine-protein kinase B-raf Homo sapiens 10 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038478&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331182 313067304 CHEMBL3354381 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258135 CC(C)c1cccc(NC(=O)c2ccc(C)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)c1 InChI=1S/C27H25N7O/c1-16(2)18-6-4-7-20(12-18)33-27(35)19-10-9-17(3)22(13-19)34-25-21(8-5-11-28-25)23-24-26(31-14-29-23)32-15-30-24/h4-16H,1-3H3,(H,28,34)(H,33,35)(H,29,30,31,32) VCGDGUIMJHDFOR-UHFFFAOYSA-N 50038479 CHEMBL3354382 Serine/threonine-protein kinase B-raf Homo sapiens 19 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038479&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73330894 313067305 CHEMBL3354382 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258136 Cc1ccc(cc1Nc1ncccc1-c1ncnc2[nH]cnc12)C(=O)Nc1cccc(c1)C#N InChI=1S/C25H18N8O/c1-15-7-8-17(25(34)32-18-5-2-4-16(10-18)12-26)11-20(15)33-23-19(6-3-9-27-23)21-22-24(30-13-28-21)31-14-29-22/h2-11,13-14H,1H3,(H,27,33)(H,32,34)(H,28,29,30,31) SKZJSARUKPUIFQ-UHFFFAOYSA-N 50038480 CHEMBL3352837 Serine/threonine-protein kinase B-raf Homo sapiens 29 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038480&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331037 313067306 CHEMBL3352837 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258137 Cc1cc(NC(=O)c2ccc(C)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)ccc1Cl InChI=1S/C25H20ClN7O/c1-14-5-6-16(25(34)32-17-7-8-19(26)15(2)10-17)11-20(14)33-23-18(4-3-9-27-23)21-22-24(30-12-28-21)31-13-29-22/h3-13H,1-2H3,(H,27,33)(H,32,34)(H,28,29,30,31) CJHJDHMTGXCQIJ-UHFFFAOYSA-N 50038482 CHEMBL3354384 Serine/threonine-protein kinase B-raf Homo sapiens 7.1 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038482&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331039 313067308 CHEMBL3354384 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258138 CN(C)c1cccc(c1)C(=O)Nc1ccc(C)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1 InChI=1S/C26H24N8O/c1-16-9-10-18(32-26(35)17-6-4-7-19(12-17)34(2)3)13-21(16)33-24-20(8-5-11-27-24)22-23-25(30-14-28-22)31-15-29-23/h4-15H,1-3H3,(H,27,33)(H,32,35)(H,28,29,30,31) UHZCQUJTKLRWKF-UHFFFAOYSA-N 50038498 CHEMBL3354840 Serine/threonine-protein kinase B-raf Homo sapiens 6.3 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038498&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73331320 313067323 CHEMBL3354840 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50258139 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 33 ChEMBL 10.1016/j.ejmech.2014.10.039 10.7270/Q21N82R6 25462267 Yang, W; Chen, Y; Zhou, X; Gu, Y; Qian, W; Zhang, F; Han, W; Lu, T; Tang, W China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50244341 CC(=O)c1ccc(cc1)N1CCN(CC1)C(=O)CN1CC[C@H](C1)C(=O)Nc1ccc(O)c(Cl)c1 InChI=1S/C25H29ClN4O4/c1-17(31)18-2-5-21(6-3-18)29-10-12-30(13-11-29)24(33)16-28-9-8-19(15-28)25(34)27-20-4-7-23(32)22(26)14-20/h2-7,14,19,32H,8-13,15-16H2,1H3,(H,27,34)/t19-/m1/s1 YPNCCYRKEHPJMN-LJQANCHMSA-N 50030881 CHEMBL3356117 Serine/threonine-protein kinase B-raf Homo sapiens >30000 ChEMBL 10.1021/jm500847m 10.7270/Q2Q52R6D 25313996 Deng, Y; Shipps, GW; Cooper, A; English, JM; Annis, DA; Carr, D; Nan, Y; Wang, T; Zhu, HY; Chuang, CC; Dayananth, P; Hruza, AW; Xiao, L; Jin, W; Kirschmeier, P; Windsor, WT; Samatar, AA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030881&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 3G7 4QYY 58985201 313065931 CHEMBL3356117 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50251789 Cc1cc(\C=N\NC(=O)Nc2ccc(cc2)-c2nc(N3CCOCC3)c3sccc3n2)cc(C)c1O InChI=1S/C26H26N6O3S/c1-16-13-18(14-17(2)22(16)33)15-27-31-26(34)28-20-5-3-19(4-6-20)24-29-21-7-12-36-23(21)25(30-24)32-8-10-35-11-9-32/h3-7,12-15,33H,8-11H2,1-2H3,(H2,28,31,34)/b27-15+ RSMAHTSDYGXRPV-JFLMPSFJSA-N 50035526 CHEMBL3343621 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2014.10.022 10.7270/Q22Z174Z 25440879 Liu, Z; Wu, S; Wang, Y; Li, R; Wang, J; Wang, L; Zhao, Y; Gong, P Shenyang Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50035526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50035526&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118717185 103943543 CHEMBL3343621 ZINC27523050 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50251790 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 12 ChEMBL 10.1016/j.ejmech.2014.10.022 10.7270/Q22Z174Z 25440879 Liu, Z; Wu, S; Wang, Y; Li, R; Wang, J; Wang, L; Zhao, Y; Gong, P Shenyang Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50267618 C[C@H](O)CNc1nccc(n1)-n1ccnc1Cc1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1 InChI=1S/C25H23ClF3N7O2/c1-15(37)14-32-23-31-8-7-21(35-23)36-10-9-30-22(36)12-16-3-2-4-17(11-16)33-24(38)34-18-5-6-20(26)19(13-18)25(27,28)29/h2-11,13,15,37H,12,14H2,1H3,(H,31,32,35)(H2,33,34,38)/t15-/m0/s1 QKYKUTTWIHRLFI-HNNXBMFYSA-N 50044783 CHEMBL3309549 Serine/threonine-protein kinase B-raf Homo sapiens 38 ChEMBL 10.1016/j.bmcl.2014.05.030 10.7270/Q2RN39HK 24878193 Kim, M; Lee, J; Jung, K; Kim, H; Aman, W; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50044783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50044783&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118705925 313068336 CHEMBL3309549 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50267619 C[C@H](O)CNc1nccc(n1)-n1ccnc1Cc1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1 InChI=1S/C25H23ClF3N7O2/c1-15(37)14-32-23-31-8-7-21(35-23)36-10-9-30-22(36)12-16-3-2-4-17(11-16)33-24(38)34-18-5-6-20(26)19(13-18)25(27,28)29/h2-11,13,15,37H,12,14H2,1H3,(H,31,32,35)(H2,33,34,38)/t15-/m0/s1 QKYKUTTWIHRLFI-HNNXBMFYSA-N 50044783 CHEMBL3309549 Serine/threonine-protein kinase B-raf Homo sapiens 186 ChEMBL 10.1016/j.bmcl.2014.05.030 10.7270/Q2RN39HK 24878193 Kim, M; Lee, J; Jung, K; Kim, H; Aman, W; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50044783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50044783&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118705925 313068336 CHEMBL3309549 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50267622 Oc1c(Br)cc(\C=C2/C(=O)Nc3ccc(I)cc23)cc1Br InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3- LMXYVLFTZRPNRV-KMKOMSMNSA-N 50085415 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one::3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one::3-[1-(3,5-Dibromo-4-hydroxy-phenyl)-meth-(Z)-ylidene]-5-iodo-1,3-dihydro-indol-2-one::CHEMBL72365::G6416 (GW5074)::GW-5074 Serine/threonine-protein kinase B-raf Homo sapiens 5.4 ChEMBL 10.1016/j.bmcl.2014.05.030 10.7270/Q2RN39HK 24878193 Kim, M; Lee, J; Jung, K; Kim, H; Aman, W; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085415&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search GWD 3ETG 5924208 103984884 CHEMBL72365 ZINC16052818 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50267625 Oc1c(Br)cc(\C=C2/C(=O)Nc3ccc(I)cc23)cc1Br InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3- LMXYVLFTZRPNRV-KMKOMSMNSA-N 50085415 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one::3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one::3-[1-(3,5-Dibromo-4-hydroxy-phenyl)-meth-(Z)-ylidene]-5-iodo-1,3-dihydro-indol-2-one::CHEMBL72365::G6416 (GW5074)::GW-5074 Serine/threonine-protein kinase B-raf Homo sapiens 11 ChEMBL 10.1016/j.bmcl.2014.05.030 10.7270/Q2RN39HK 24878193 Kim, M; Lee, J; Jung, K; Kim, H; Aman, W; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085415&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search GWD 3ETG 5924208 103984884 CHEMBL72365 ZINC16052818 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50286557 CCN(CC)CCCNc1nc(nc2ccsc12)-c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1 InChI=1S/C26H29ClN6OS/c1-3-33(4-2)16-5-15-28-25-23-22(14-17-35-23)31-24(32-25)18-6-10-20(11-7-18)29-26(34)30-21-12-8-19(27)9-13-21/h6-14,17H,3-5,15-16H2,1-2H3,(H,28,31,32)(H2,29,30,34) KVQXSRPPMDSZLB-UHFFFAOYSA-N 50055864 CHEMBL3326099 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2014.07.099 10.7270/Q24T6M19 25086238 Liu, Z; Wang, Y; Lin, H; Zuo, D; Wang, L; Zhao, Y; Gong, P Shenyang Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055864&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118711367 313069937 CHEMBL3326099 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50286558 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 12 ChEMBL 10.1016/j.ejmech.2014.07.099 10.7270/Q24T6M19 25086238 Liu, Z; Wang, Y; Lin, H; Zuo, D; Wang, L; Zhao, Y; Gong, P Shenyang Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50277944 Cc1cccc(n1)-c1n[nH]cc1-c1ccc2ncccc2n1 InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22) LBPKYPYHDKKRFS-UHFFFAOYSA-N 50151347 2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine::2-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-[1,5]naphthyridine::CHEMBL185238 Serine/threonine-protein kinase B-raf Homo sapiens >16000 ChEMBL 10.1021/jm0400247 10.7270/Q2VQ325T 15317461 Gellibert, F; Woolven, J; Fouchet, MH; Mathews, N; Goodland, H; Lovegrove, V; Laroze, A; Nguyen, VL; Sautet, S; Wang, R; Janson, C; Smith, W; Krysa, G; Boullay, V; De Gouville, AC; Huet, S; Hartley, D GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50151347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50151347&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 449054 104039525 CHEMBL185238 ZINC16052804 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50282283 Cn1c(Nc2cccc(c2)C(C)(C)C)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)-c3ccccc3)ccc12 InChI=1S/C32H30N6O/c1-32(2,3)22-11-8-12-23(17-22)35-31-37-26-18-24(13-14-29(26)38(31)4)39-25-15-16-33-27(19-25)30-34-20-28(36-30)21-9-6-5-7-10-21/h5-20H,1-4H3,(H,34,36)(H,35,37) PYBNNACSMHESLC-UHFFFAOYSA-N 50131831 CHEMBL3632718 Serine/threonine-protein kinase B-raf Homo sapiens 480 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131831&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16064748 104022888 CHEMBL3632718 ZINC27109708 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50282284 Cn1c(Nc2cccc(c2)C(C)(C)C)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C27H25F3N6O/c1-26(2,3)16-6-5-7-17(12-16)33-25-34-20-13-18(8-9-22(20)36(25)4)37-19-10-11-31-21(14-19)24-32-15-23(35-24)27(28,29)30/h5-15H,1-4H3,(H,32,35)(H,33,34) SCUGTCMSRMQNNQ-UHFFFAOYSA-N 50131822 CHEMBL3632719 Serine/threonine-protein kinase B-raf Homo sapiens 120 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131822&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16064750 104022879 CHEMBL3632719 ZINC27109831 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50282285 Cn1c(Nc2ccc(cc2)C(C)(C)C)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C27H25F3N6O/c1-26(2,3)16-5-7-17(8-6-16)33-25-34-20-13-18(9-10-22(20)36(25)4)37-19-11-12-31-21(14-19)24-32-15-23(35-24)27(28,29)30/h5-15H,1-4H3,(H,32,35)(H,33,34) JSLFPRZIKITLJX-UHFFFAOYSA-N 50131830 CHEMBL3632720 Serine/threonine-protein kinase B-raf Homo sapiens 130 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131830&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16064288 104022887 CHEMBL3632720 ZINC27192014 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50282286 Cn1c(Nc2cc(ccc2F)C(C)(C)C)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C27H24F4N6O/c1-26(2,3)15-5-7-18(28)19(11-15)34-25-35-20-12-16(6-8-22(20)37(25)4)38-17-9-10-32-21(13-17)24-33-14-23(36-24)27(29,30)31/h5-14H,1-4H3,(H,33,36)(H,34,35) KLUQUTDAFSUQQQ-UHFFFAOYSA-N 50131827 CHEMBL3632721 Serine/threonine-protein kinase B-raf Homo sapiens 42 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131827&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16064892 104022884 CHEMBL3632721 ZINC40487258 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50282287 Cn1c(Nc2cccc(c2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-6-5-15(10-17(19)34-22(36)33-14-4-2-3-13(9-14)23(25,26)27)37-16-7-8-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) DVJYMPYLFMEZMR-UHFFFAOYSA-N 50131826 CHEMBL3632722 Serine/threonine-protein kinase B-raf Homo sapiens 780 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131826&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16064449 104022883 CHEMBL3632722 ZINC27110136 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50282288 Cn1c(Nc2cc(ccc2F)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H15F7N6O/c1-37-19-5-3-13(38-14-6-7-32-18(10-14)21-33-11-20(36-21)24(29,30)31)9-17(19)35-22(37)34-16-8-12(23(26,27)28)2-4-15(16)25/h2-11H,1H3,(H,33,36)(H,34,35) BSOYRWMMIWLZGL-UHFFFAOYSA-N 50131825 CHEMBL3632723 Serine/threonine-protein kinase B-raf Homo sapiens 210 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131825&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16064891 104022882 CHEMBL3632723 ZINC27190459 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50282289 Cc1cnc([nH]1)-c1cc(Oc2ccc3n(C)c(Nc4cc(ccc4F)C(F)(F)F)nc3c2)ccn1 InChI=1S/C24H18F4N6O/c1-13-12-30-22(31-13)20-11-16(7-8-29-20)35-15-4-6-21-19(10-15)33-23(34(21)2)32-18-9-14(24(26,27)28)3-5-17(18)25/h3-12H,1-2H3,(H,30,31)(H,32,33) RECKFDASWBRPIB-UHFFFAOYSA-N 50131824 CHEMBL3632724 Serine/threonine-protein kinase B-raf Homo sapiens 620 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131824&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16064893 104022881 CHEMBL3632724 ZINC36107858 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50282290 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Serine/threonine-protein kinase B-raf Homo sapiens 140 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50282292 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Serine/threonine-protein kinase B-raf Homo sapiens 0.500000 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50282293 Cn1c(Nc2cccc(c2)C(C)(C)C)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C27H25F3N6O/c1-26(2,3)16-6-5-7-17(12-16)33-25-34-20-13-18(8-9-22(20)36(25)4)37-19-10-11-31-21(14-19)24-32-15-23(35-24)27(28,29)30/h5-15H,1-4H3,(H,32,35)(H,33,34) SCUGTCMSRMQNNQ-UHFFFAOYSA-N 50131822 CHEMBL3632719 Serine/threonine-protein kinase B-raf Homo sapiens 55 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131822&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16064750 104022879 CHEMBL3632719 ZINC27109831 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50278263 Cn1c(Nc2cccc(c2)C(C)(C)C)nc2cc(Oc3ccnc(c3)-c3ncc[nH]3)ccc12 InChI=1S/C16H15FN4O/c1-2-22-11-21-19-15(12-3-5-14(17)6-4-12)16(20-21)13-7-9-18-10-8-13/h3-10H,2,11H2,1H3 DGXCRAFGLIAUJR-UHFFFAOYSA-N 50127687 CHEMBL3632717 Serine/threonine-protein kinase B-raf Homo sapiens 90 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127687&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 60098131 104019534 CHEMBL3632717 ZINC13489722 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50278264 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cccc(c4)C(C)(C)C)nc3c2)ccn1 InChI=1S/C25H27N5O2/c1-16(31)27-23-15-20(11-12-26-23)32-19-9-10-22-21(14-19)29-24(30(22)5)28-18-8-6-7-17(13-18)25(2,3)4/h6-15H,1-5H3,(H,28,29)(H,26,27,31) WSBZFFNSBMBYQA-UHFFFAOYSA-N 50026679 CHEMBL3335371 Serine/threonine-protein kinase B-raf Homo sapiens 3.0 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026679&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 59790029 103936266 CHEMBL3335371 ZINC29340348 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50278265 CNC(=O)c1cc(Oc2ccc3n(C)c(Nc4cccc(c4)C(C)(C)C)nc3c2)ccn1 InChI=1S/C25H27N5O2/c1-25(2,3)16-7-6-8-17(13-16)28-24-29-20-14-18(9-10-22(20)30(24)5)32-19-11-12-27-21(15-19)23(31)26-4/h6-15H,1-5H3,(H,26,31)(H,28,29) SILANKVZJSUJHJ-UHFFFAOYSA-N 26028 4-({2-[(3-tert-butylphenyl)(methyl)amino]-1H-1,3-benzodiazol-5-yl}oxy)-N-methylpyridine-2-carboxamide::arylaminobenzimidazole, 23 Serine/threonine-protein kinase B-raf Homo sapiens 45 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26028&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 22041319 56464465 ZINC40895399 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50278266 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Serine/threonine-protein kinase B-raf Homo sapiens 40 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50278267 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Serine/threonine-protein kinase B-raf Homo sapiens 40 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50278268 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Serine/threonine-protein kinase B-raf Homo sapiens 40 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50278270 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Serine/threonine-protein kinase B-raf Homo sapiens 70 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50281538 CNC(=O)c1cc(Oc2ccc3n(C)c(Nc4cccc(c4)C(C)(C)C)nc3c2)ccn1 InChI=1S/C25H27N5O2/c1-25(2,3)16-7-6-8-17(13-16)28-24-29-20-14-18(9-10-22(20)30(24)5)32-19-11-12-27-21(15-19)23(31)26-4/h6-15H,1-5H3,(H,26,31)(H,28,29) SILANKVZJSUJHJ-UHFFFAOYSA-N 26028 4-({2-[(3-tert-butylphenyl)(methyl)amino]-1H-1,3-benzodiazol-5-yl}oxy)-N-methylpyridine-2-carboxamide::arylaminobenzimidazole, 23 Serine/threonine-protein kinase B-raf Homo sapiens 280 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26028&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 22041319 56464465 ZINC40895399 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50281539 CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cccc(c4)C(C)(C)C)nc3c2)ccn1 InChI=1S/C25H27N5O2/c1-16(31)27-23-15-20(11-12-26-23)32-19-9-10-22-21(14-19)29-24(30(22)5)28-18-8-6-7-17(13-18)25(2,3)4/h6-15H,1-5H3,(H,28,29)(H,26,27,31) WSBZFFNSBMBYQA-UHFFFAOYSA-N 50026679 CHEMBL3335371 Serine/threonine-protein kinase B-raf Homo sapiens 44 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026679&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 59790029 103936266 CHEMBL3335371 ZINC29340348 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50281540 Cn1c(Nc2cccc(c2)C(C)(C)C)nc2cc(Oc3ccnc(c3)-c3ncc[nH]3)ccc12 InChI=1S/C16H15FN4O/c1-2-22-11-21-19-15(12-3-5-14(17)6-4-12)16(20-21)13-7-9-18-10-8-13/h3-10H,2,11H2,1H3 DGXCRAFGLIAUJR-UHFFFAOYSA-N 50127687 CHEMBL3632717 Serine/threonine-protein kinase B-raf Homo sapiens 390 ChEMBL 10.1021/ml500526p 10.7270/Q28W3G4S 26396681 Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127687&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 60098131 104019534 CHEMBL3632717 ZINC13489722 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50292559 COc1ccc(cc1)C(=O)Nc1ccc(C)c(c1)C(=O)Nc1ccc(nc1)-c1ncc[nH]1 InChI=1S/C24H21N5O3/c1-15-3-6-17(28-23(30)16-4-8-19(32-2)9-5-16)13-20(15)24(31)29-18-7-10-21(27-14-18)22-25-11-12-26-22/h3-14H,1-2H3,(H,25,26)(H,28,30)(H,29,31) ORXPYRNFLBIKQO-UHFFFAOYSA-N 50101400 CHEMBL3393800 Serine/threonine-protein kinase B-raf Homo sapiens 40400 ChEMBL 10.1016/j.ejmech.2014.11.008 10.7270/Q2S18451 25461318 Jiao, Y; Xin, BT; Zhang, Y; Wu, J; Lu, X; Zheng, Y; Tang, W; Zhou, X China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101400&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118725687 318490816 CHEMBL3393800 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50292561 FC(F)(F)c1cc(ccc1Cl)C(=O)Nc1ccc(Cl)c(c1)C(=O)Nc1ccc(nc1)-c1ncc[nH]1 InChI=1S/C23H14Cl2F3N5O2/c24-17-5-2-13(32-21(34)12-1-4-18(25)16(9-12)23(26,27)28)10-15(17)22(35)33-14-3-6-19(31-11-14)20-29-7-8-30-20/h1-11H,(H,29,30)(H,32,34)(H,33,35) QEMXFLNJOAETGF-UHFFFAOYSA-N 50059790 CHEMBL3393803 Serine/threonine-protein kinase B-raf Homo sapiens 650 ChEMBL 10.1016/j.ejmech.2014.11.008 10.7270/Q2S18451 25461318 Jiao, Y; Xin, BT; Zhang, Y; Wu, J; Lu, X; Zheng, Y; Tang, W; Zhou, X China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059790&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118725690 103955571 CHEMBL3393803 ZINC26748387 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50292562 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 38 ChEMBL 10.1016/j.ejmech.2014.11.008 10.7270/Q2S18451 25461318 Jiao, Y; Xin, BT; Zhang, Y; Wu, J; Lu, X; Zheng, Y; Tang, W; Zhou, X China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318006 CCCS(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c(F)c1 InChI=1S/C17H14ClF2N3O3S/c1-2-3-27(25,26)23-10-5-13(19)15(14(20)6-10)16(24)12-8-22-17-11(12)4-9(18)7-21-17/h4-8,23H,2-3H2,1H3,(H,21,22) IIDTUADQWHMXCU-UHFFFAOYSA-N 50075576 CHEMBL3415554 Serine/threonine-protein kinase B-raf Homo sapiens 160 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075576&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531936 313073172 CHEMBL3415554 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318009 CCN(C)S(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c(F)c1 InChI=1S/C23H19ClF2N4O3S/c1-3-30(2)34(32,33)29-16-9-19(25)21(20(26)10-16)22(31)18-12-28-23-17(18)8-14(11-27-23)13-4-6-15(24)7-5-13/h4-12,29H,3H2,1-2H3,(H,27,28) LLAFAUCUKNMECC-UHFFFAOYSA-N 50075577 CHEMBL3415556 Serine/threonine-protein kinase B-raf Homo sapiens <100 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075577&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531937 313073173 CHEMBL3415556 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318010 CCCS(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c(F)c1 InChI=1S/C17H14ClF2N3O3S/c1-2-3-27(25,26)23-10-5-13(19)15(14(20)6-10)16(24)12-8-22-17-11(12)4-9(18)7-21-17/h4-8,23H,2-3H2,1H3,(H,21,22) IIDTUADQWHMXCU-UHFFFAOYSA-N 50075576 CHEMBL3415554 Serine/threonine-protein kinase B-raf Homo sapiens 13 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075576&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531936 313073172 CHEMBL3415554 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318011 CCCS(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c(F)c1 InChI=1S/C23H18ClF2N3O3S/c1-2-7-33(31,32)29-16-9-19(25)21(20(26)10-16)22(30)18-12-28-23-17(18)8-14(11-27-23)13-3-5-15(24)6-4-13/h3-6,8-12,29H,2,7H2,1H3,(H,27,28) WCJKXQIGIZQRIB-UHFFFAOYSA-N 50075578 CHEMBL3415553 Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075578&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90120675 313073174 CHEMBL3415553 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318012 CCN(C)S(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c(F)c1 InChI=1S/C17H15ClF2N4O3S/c1-3-24(2)28(26,27)23-10-5-13(19)15(14(20)6-10)16(25)12-8-22-17-11(12)4-9(18)7-21-17/h4-8,23H,3H2,1-2H3,(H,21,22) JLIADOPNPNQIHY-UHFFFAOYSA-N 50075581 CHEMBL3415555 Serine/threonine-protein kinase B-raf Homo sapiens <100 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075581&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531938 313073175 CHEMBL3415555 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318013 CCCS(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c(F)c1 InChI=1S/C23H18ClF2N3O3S/c1-2-7-33(31,32)29-16-9-19(25)21(20(26)10-16)22(30)18-12-28-23-17(18)8-14(11-27-23)13-3-5-15(24)6-4-13/h3-6,8-12,29H,2,7H2,1H3,(H,27,28) WCJKXQIGIZQRIB-UHFFFAOYSA-N 50075578 CHEMBL3415553 Serine/threonine-protein kinase B-raf Homo sapiens 31 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075578&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90120675 313073174 CHEMBL3415553 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318015 CCCS(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c(F)c1 InChI=1S/C23H18ClF2N3O3S/c1-2-7-33(31,32)29-16-9-19(25)21(20(26)10-16)22(30)18-12-28-23-17(18)8-14(11-27-23)13-3-5-15(24)6-4-13/h3-6,8-12,29H,2,7H2,1H3,(H,27,28) WCJKXQIGIZQRIB-UHFFFAOYSA-N 50075578 CHEMBL3415553 Serine/threonine-protein kinase B-raf Homo sapiens 130 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075578&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90120675 313073174 CHEMBL3415553 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318016 CCCS(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c(F)c1 InChI=1S/C17H14ClF2N3O3S/c1-2-3-27(25,26)23-10-5-13(19)15(14(20)6-10)16(24)12-8-22-17-11(12)4-9(18)7-21-17/h4-8,23H,2-3H2,1H3,(H,21,22) IIDTUADQWHMXCU-UHFFFAOYSA-N 50075576 CHEMBL3415554 Serine/threonine-protein kinase B-raf Homo sapiens 140 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075576&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531936 313073172 CHEMBL3415554 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318017 CCN(C)S(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c(F)c1 InChI=1S/C17H15ClF2N4O3S/c1-3-24(2)28(26,27)23-10-5-13(19)15(14(20)6-10)16(25)12-8-22-17-11(12)4-9(18)7-21-17/h4-8,23H,3H2,1-2H3,(H,21,22) JLIADOPNPNQIHY-UHFFFAOYSA-N 50075581 CHEMBL3415555 Serine/threonine-protein kinase B-raf Homo sapiens 550 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075581&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531938 313073175 CHEMBL3415555 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318018 CCN(C)S(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c(F)c1 InChI=1S/C23H19ClF2N4O3S/c1-3-30(2)34(32,33)29-16-9-19(25)21(20(26)10-16)22(31)18-12-28-23-17(18)8-14(11-27-23)13-4-6-15(24)7-5-13/h4-12,29H,3H2,1-2H3,(H,27,28) LLAFAUCUKNMECC-UHFFFAOYSA-N 50075577 CHEMBL3415556 Serine/threonine-protein kinase B-raf Homo sapiens 1410 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075577&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531937 313073173 CHEMBL3415556 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318019 CCCS(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c(F)c1 InChI=1S/C23H18ClF2N3O3S/c1-2-7-33(31,32)29-16-9-19(25)21(20(26)10-16)22(30)18-12-28-23-17(18)8-14(11-27-23)13-3-5-15(24)6-4-13/h3-6,8-12,29H,2,7H2,1H3,(H,27,28) WCJKXQIGIZQRIB-UHFFFAOYSA-N 50075578 CHEMBL3415553 Serine/threonine-protein kinase B-raf Homo sapiens 62 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075578&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90120675 313073174 CHEMBL3415553 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318021 CCCS(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c(F)c1 InChI=1S/C17H14ClF2N3O3S/c1-2-3-27(25,26)23-10-5-13(19)15(14(20)6-10)16(24)12-8-22-17-11(12)4-9(18)7-21-17/h4-8,23H,2-3H2,1H3,(H,21,22) IIDTUADQWHMXCU-UHFFFAOYSA-N 50075576 CHEMBL3415554 Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075576&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531936 313073172 CHEMBL3415554 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318022 CCN(C)S(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c(F)c1 InChI=1S/C17H15ClF2N4O3S/c1-3-24(2)28(26,27)23-10-5-13(19)15(14(20)6-10)16(25)12-8-22-17-11(12)4-9(18)7-21-17/h4-8,23H,3H2,1-2H3,(H,21,22) JLIADOPNPNQIHY-UHFFFAOYSA-N 50075581 CHEMBL3415555 Serine/threonine-protein kinase B-raf Homo sapiens 400 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075581&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531938 313073175 CHEMBL3415555 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318023 CCN(C)S(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c(F)c1 InChI=1S/C23H19ClF2N4O3S/c1-3-30(2)34(32,33)29-16-9-19(25)21(20(26)10-16)22(31)18-12-28-23-17(18)8-14(11-27-23)13-4-6-15(24)7-5-13/h4-12,29H,3H2,1-2H3,(H,27,28) LLAFAUCUKNMECC-UHFFFAOYSA-N 50075577 CHEMBL3415556 Serine/threonine-protein kinase B-raf Homo sapiens 690 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075577&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531937 313073173 CHEMBL3415556 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318024 CCCS(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c(F)c1 InChI=1S/C17H14ClF2N3O3S/c1-2-3-27(25,26)23-10-5-13(19)15(14(20)6-10)16(24)12-8-22-17-11(12)4-9(18)7-21-17/h4-8,23H,2-3H2,1H3,(H,21,22) IIDTUADQWHMXCU-UHFFFAOYSA-N 50075576 CHEMBL3415554 Serine/threonine-protein kinase B-raf Homo sapiens <500 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075576&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531936 313073172 CHEMBL3415554 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318026 CCN(C)S(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c(F)c1 InChI=1S/C17H15ClF2N4O3S/c1-3-24(2)28(26,27)23-10-5-13(19)15(14(20)6-10)16(25)12-8-22-17-11(12)4-9(18)7-21-17/h4-8,23H,3H2,1-2H3,(H,21,22) JLIADOPNPNQIHY-UHFFFAOYSA-N 50075581 CHEMBL3415555 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075581&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531938 313073175 CHEMBL3415555 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318029 CCN(C)S(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c(F)c1 InChI=1S/C23H19ClF2N4O3S/c1-3-30(2)34(32,33)29-16-9-19(25)21(20(26)10-16)22(31)18-12-28-23-17(18)8-14(11-27-23)13-4-6-15(24)7-5-13/h4-12,29H,3H2,1-2H3,(H,27,28) LLAFAUCUKNMECC-UHFFFAOYSA-N 50075577 CHEMBL3415556 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075577&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531937 313073173 CHEMBL3415556 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318030 CCCS(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c(F)c1 InChI=1S/C17H14ClF2N3O3S/c1-2-3-27(25,26)23-10-5-13(19)15(14(20)6-10)16(24)12-8-22-17-11(12)4-9(18)7-21-17/h4-8,23H,2-3H2,1H3,(H,21,22) IIDTUADQWHMXCU-UHFFFAOYSA-N 50075576 CHEMBL3415554 Serine/threonine-protein kinase B-raf Homo sapiens <800 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075576&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531936 313073172 CHEMBL3415554 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318031 CCN(C)S(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c(F)c1 InChI=1S/C17H15ClF2N4O3S/c1-3-24(2)28(26,27)23-10-5-13(19)15(14(20)6-10)16(25)12-8-22-17-11(12)4-9(18)7-21-17/h4-8,23H,3H2,1-2H3,(H,21,22) JLIADOPNPNQIHY-UHFFFAOYSA-N 50075581 CHEMBL3415555 Serine/threonine-protein kinase B-raf Homo sapiens <1000 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075581&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531938 313073175 CHEMBL3415555 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312657 CNc1ncc2ccc(Oc3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2n1 InChI=1S/C33H28N6O3/c1-20-14-17-25(28(34)31(20)42-24-16-15-22-19-36-33(35-2)37-26(22)18-24)30(40)27-29(21-10-6-4-7-11-21)38(3)39(32(27)41)23-12-8-5-9-13-23/h4-19H,34H2,1-3H3,(H,35,36,37) AOPRQCPYNNEYPV-UHFFFAOYSA-N 50072070 CHEMBL3407504 Serine/threonine-protein kinase B-raf Homo sapiens 190 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072070&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730410 313072580 CHEMBL3407504 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50318032 CCN(C)S(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c(F)c1 InChI=1S/C23H19ClF2N4O3S/c1-3-30(2)34(32,33)29-16-9-19(25)21(20(26)10-16)22(31)18-12-28-23-17(18)8-14(11-27-23)13-4-6-15(24)7-5-13/h4-12,29H,3H2,1-2H3,(H,27,28) LLAFAUCUKNMECC-UHFFFAOYSA-N 50075577 CHEMBL3415556 Serine/threonine-protein kinase B-raf Homo sapiens <1000 ChEMBL 10.1021/jm501667n 10.7270/Q27M09N7 25611072 Arora, R; Di Michele, M; Stes, E; Vandermarliere, E; Martens, L; Gevaert, K; Van Heerde, E; Linders, JT; Brehmer, D; Jacoby, E; Bonnet, P UMR CNRS-Universit£ d'Orl£ans 7311 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075577&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 102531937 313073173 CHEMBL3415556 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312815 Cn1cc(-c2ccc3N(CC(=O)c4cc(F)cc(c4)C(F)(F)F)CCc3c2)c2c(N)ncnc12 InChI=1S/C24H19F4N5O/c1-32-10-18(21-22(29)30-12-31-23(21)32)13-2-3-19-14(6-13)4-5-33(19)11-20(34)15-7-16(24(26,27)28)9-17(25)8-15/h2-3,6-10,12H,4-5,11H2,1H3,(H2,29,30,31) ZWDWGLVLLJCBMR-UHFFFAOYSA-N 50072075 CHEMBL3407846 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072075&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730408 313072585 CHEMBL3407846 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312816 CNc1ncc2cc(ccc2n1)-c1c(C)ccc(C(=O)Nc2ccc(OC)c(c2)C(F)(F)F)c1N InChI=1S/C25H22F3N5O2/c1-13-4-7-17(23(34)32-16-6-9-20(35-3)18(11-16)25(26,27)28)22(29)21(13)14-5-8-19-15(10-14)12-31-24(30-2)33-19/h4-12H,29H2,1-3H3,(H,32,34)(H,30,31,33) NYVUSSXLPQHLMH-UHFFFAOYSA-N 50072074 CHEMBL3407847 Serine/threonine-protein kinase B-raf Homo sapiens 8.0 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072074&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 3Z1 4X7J 86583042 313072584 CHEMBL3407847 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312817 COc1cc2nccc(Oc3ccc(NC(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC InChI=1S/C33H27N5O5/c1-37-31(21-10-6-4-7-11-21)30(33(40)38(37)22-12-8-5-9-13-22)32(39)36-29-15-14-23(20-35-29)43-26-16-17-34-25-19-28(42-3)27(41-2)18-24(25)26/h4-20H,1-3H3,(H,35,36,39) PVNWAPAWLNSQHB-UHFFFAOYSA-N 50072073 CHEMBL3407848 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072073&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730409 313072583 CHEMBL3407848 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312818 CNc1ncc2ccc(Oc3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2n1 InChI=1S/C33H28N6O3/c1-20-14-17-25(28(34)31(20)42-24-16-15-22-19-36-33(35-2)37-26(22)18-24)30(40)27-29(21-10-6-4-7-11-21)38(3)39(32(27)41)23-12-8-5-9-13-23/h4-19H,34H2,1-3H3,(H,35,36,37) AOPRQCPYNNEYPV-UHFFFAOYSA-N 50072070 CHEMBL3407504 Serine/threonine-protein kinase B-raf Homo sapiens 300 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072070&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730410 313072580 CHEMBL3407504 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312819 CNc1ncc2ccc(Oc3cc(ccc3C)C(=O)c3c(-c4ccccc4)n(C)n(-c4ccccc4)c3=O)cc2n1 InChI=1S/C33H27N5O3/c1-21-14-15-23(18-28(21)41-26-17-16-24-20-35-33(34-2)36-27(24)19-26)31(39)29-30(22-10-6-4-7-11-22)37(3)38(32(29)40)25-12-8-5-9-13-25/h4-20H,1-3H3,(H,34,35,36) QLCVZRYQHBSADC-UHFFFAOYSA-N 50072072 CHEMBL3407849 Serine/threonine-protein kinase B-raf Homo sapiens 8.0 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072072&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730411 313072582 CHEMBL3407849 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312820 CNc1ncc2ccc(Oc3cc(ccc3N)C(=O)c3c(-c4ccccc4)n(C)n(-c4ccccc4)c3=O)cc2n1 InChI=1S/C32H26N6O3/c1-34-32-35-19-22-13-15-24(18-26(22)36-32)41-27-17-21(14-16-25(27)33)30(39)28-29(20-9-5-3-6-10-20)37(2)38(31(28)40)23-11-7-4-8-12-23/h3-19H,33H2,1-2H3,(H,34,35,36) JGQCTMHFTXGHEP-UHFFFAOYSA-N 50071957 CHEMBL3407850 Serine/threonine-protein kinase B-raf Homo sapiens 66 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071957&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730412 313048458 CHEMBL3407850 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312824 CNc1ncc2ccc(Oc3cc(ccc3Cl)C(=O)c3c(-c4ccccc4)n(C)n(-c4ccccc4)c3=O)cc2n1 InChI=1S/C32H24ClN5O3/c1-34-32-35-19-22-13-15-24(18-26(22)36-32)41-27-17-21(14-16-25(27)33)30(39)28-29(20-9-5-3-6-10-20)37(2)38(31(28)40)23-11-7-4-8-12-23/h3-19H,1-2H3,(H,34,35,36) LTKYUQAQPQMHNJ-UHFFFAOYSA-N 50072026 CHEMBL3407851 Serine/threonine-protein kinase B-raf Homo sapiens 13 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072026&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730413 103965716 CHEMBL3407851 ZINC26652349 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312826 CNc1ncc2c(F)cc(Oc3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2n1 InChI=1S/C33H27FN6O3/c1-19-14-15-23(28(35)31(19)43-22-16-25(34)24-18-37-33(36-2)38-26(24)17-22)30(41)27-29(20-10-6-4-7-11-20)39(3)40(32(27)42)21-12-8-5-9-13-21/h4-18H,35H2,1-3H3,(H,36,37,38) KFTURBBKSPHDAZ-UHFFFAOYSA-N 50072027 CHEMBL3407852 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072027&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730414 103965717 CHEMBL3407852 ZINC53156605 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312827 CNc1ncc2c(Cl)cc(Oc3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2n1 InChI=1S/C33H27ClN6O3/c1-19-14-15-23(28(35)31(19)43-22-16-25(34)24-18-37-33(36-2)38-26(24)17-22)30(41)27-29(20-10-6-4-7-11-20)39(3)40(32(27)42)21-12-8-5-9-13-21/h4-18H,35H2,1-3H3,(H,36,37,38) MOEKDAUMPQWOMG-UHFFFAOYSA-N 50072028 CHEMBL3407853 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072028&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730415 103965718 CHEMBL3407853 ZINC26655956 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312829 Cc1ncc2ccc(Oc3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2n1 InChI=1S/C33H27N5O3/c1-20-14-17-26(29(34)32(20)41-25-16-15-23-19-35-21(2)36-27(23)18-25)31(39)28-30(22-10-6-4-7-11-22)37(3)38(33(28)40)24-12-8-5-9-13-24/h4-19H,34H2,1-3H3 YVGNBSYAGOXRNK-UHFFFAOYSA-N 50072029 CHEMBL3407854 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072029&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730416 103965719 CHEMBL3407854 ZINC00578676 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312831 Cc1nc2cc(ccc2s1)-c1c(C)ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c1N InChI=1S/C32H26N4O2S/c1-19-14-16-24(29(33)27(19)22-15-17-26-25(18-22)34-20(2)39-26)31(37)28-30(21-10-6-4-7-11-21)35(3)36(32(28)38)23-12-8-5-9-13-23/h4-18H,33H2,1-3H3 FMKSPJHSPNIVAS-UHFFFAOYSA-N 50072071 CHEMBL3407855 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072071&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730417 313072581 CHEMBL3407855 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312834 Cc1nc2ccc(cc2s1)-c1c(C)ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c1N InChI=1S/C32H26N4O2S/c1-19-14-16-24(29(33)27(19)22-15-17-25-26(18-22)39-20(2)34-25)31(37)28-30(21-10-6-4-7-11-21)35(3)36(32(28)38)23-12-8-5-9-13-23/h4-18H,33H2,1-3H3 CTFSTDZNMXJUAP-UHFFFAOYSA-N 50072030 CHEMBL3407856 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072030&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730418 103965720 CHEMBL3407856 ZINC53156630 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312835 CNc1nc2ccc(cc2s1)-c1c(C)ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c1N InChI=1S/C32H27N5O2S/c1-19-14-16-23(28(33)26(19)21-15-17-24-25(18-21)40-32(34-2)35-24)30(38)27-29(20-10-6-4-7-11-20)36(3)37(31(27)39)22-12-8-5-9-13-22/h4-18H,33H2,1-3H3,(H,34,35) XUIZYNXJUPSUNY-UHFFFAOYSA-N 50072031 CHEMBL3407857 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072031&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 3Z4 4X7L 86583044 103965721 CHEMBL3407857 ZINC26657388 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312837 Cc1ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c(N)c1-c1ccc2nc(N)sc2c1 InChI=1S/C31H25N5O2S/c1-18-13-15-22(27(32)25(18)20-14-16-23-24(17-20)39-31(33)34-23)29(37)26-28(19-9-5-3-6-10-19)35(2)36(30(26)38)21-11-7-4-8-12-21/h3-17H,32H2,1-2H3,(H2,33,34) GNBOANVFMKLPAQ-UHFFFAOYSA-N 50072032 CHEMBL3407858 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072032&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730419 103965722 CHEMBL3407858 ZINC00578682 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312838 Cc1ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c(N)c1-c1ccc2nc(CF)sc2c1 InChI=1S/C32H25FN4O2S/c1-19-13-15-23(29(34)27(19)21-14-16-24-25(17-21)40-26(18-33)35-24)31(38)28-30(20-9-5-3-6-10-20)36(2)37(32(28)39)22-11-7-4-8-12-22/h3-17H,18,34H2,1-2H3 KLMUKGOQPKWEOQ-UHFFFAOYSA-N 50072033 CHEMBL3407859 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072033&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730420 103965723 CHEMBL3407859 ZINC00578683 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312839 Cc1ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c(N)c1-c1ccc2nc(sc2c1)C(F)F InChI=1S/C32H24F2N4O2S/c1-18-13-15-22(27(35)25(18)20-14-16-23-24(17-20)41-31(36-23)30(33)34)29(39)26-28(19-9-5-3-6-10-19)37(2)38(32(26)40)21-11-7-4-8-12-21/h3-17,30H,35H2,1-2H3 SSCBWUSFTGYEDY-UHFFFAOYSA-N 50072034 CHEMBL3407860 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072034&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730421 103965724 CHEMBL3407860 ZINC26656979 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312841 Cc1ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c(N)c1-c1ccc2nc(sc2c1)C(F)(F)F InChI=1S/C32H23F3N4O2S/c1-18-13-15-22(27(36)25(18)20-14-16-23-24(17-20)42-31(37-23)32(33,34)35)29(40)26-28(19-9-5-3-6-10-19)38(2)39(30(26)41)21-11-7-4-8-12-21/h3-17H,36H2,1-2H3 DRQQNHJHIDNZOM-UHFFFAOYSA-N 50072035 CHEMBL3407861 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072035&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730422 103965725 CHEMBL3407861 ZINC26658146 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312842 Cc1ccc2cc(ccc2n1)-c1c(C)ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c1N InChI=1S/C34H28N4O2/c1-21-14-18-27(31(35)29(21)25-17-19-28-24(20-25)16-15-22(2)36-28)33(39)30-32(23-10-6-4-7-11-23)37(3)38(34(30)40)26-12-8-5-9-13-26/h4-20H,35H2,1-3H3 YPPSMYLMSKHYAY-UHFFFAOYSA-N 50072036 CHEMBL3407862 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072036&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 3Z5 4X7N 86583045 103965726 CHEMBL3407862 ZINC26652330 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312843 Cc1nc(N)c2c(cn(C)c2n1)-c1ccc2N(CC(=O)c3cc(F)cc(c3)C(F)(F)F)CCc2c1 InChI=1S/C25H21F4N5O/c1-13-31-23(30)22-19(11-33(2)24(22)32-13)14-3-4-20-15(7-14)5-6-34(20)12-21(35)16-8-17(25(27,28)29)10-18(26)9-16/h3-4,7-11H,5-6,12H2,1-2H3,(H2,30,31,32) OFKRFKMCADRHKY-UHFFFAOYSA-N 50072038 CHEMBL3407863 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072038&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118730423 103965728 CHEMBL3407863 ZINC26659786 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50312886 CNc1ncc2cc(ccc2n1)-c1c(C)ccc(C(=O)Nc2ccc(OC)c(c2)C(F)(F)F)c1N InChI=1S/C25H22F3N5O2/c1-13-4-7-17(23(34)32-16-6-9-20(35-3)18(11-16)25(26,27)28)22(29)21(13)14-5-8-19-15(10-14)12-31-24(30-2)33-19/h4-12H,29H2,1-3H3,(H,32,34)(H,30,31,33) NYVUSSXLPQHLMH-UHFFFAOYSA-N 50072074 CHEMBL3407847 Serine/threonine-protein kinase B-raf Homo sapiens 11 ChEMBL 10.1021/jm5017494 10.7270/Q27W6DWN 25587754 Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072074&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 3Z1 4X7J 86583042 313072584 CHEMBL3407847 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50336869 CCn1nc(C#Cc2cc(ccc2C)C(=O)Nc2ccc(CN3CCN(C)CC3)c(c2)C(F)(F)F)c2c(N)ncnc12 InChI=1S/C30H31F3N8O/c1-4-41-28-26(27(34)35-18-36-28)25(38-41)10-8-20-15-21(6-5-19(20)2)29(42)37-23-9-7-22(24(16-23)30(31,32)33)17-40-13-11-39(3)12-14-40/h5-7,9,15-16,18H,4,11-14,17H2,1-3H3,(H,37,42)(H2,34,35,36) BNRXMSGHPVYSDK-UHFFFAOYSA-N 50086441 CHEMBL3426225::US10266537, Compound 3 Serine/threonine-protein kinase B-raf Homo sapiens 92 ChEMBL 10.1021/acs.jmedchem.5b00270 10.7270/Q2J38V91 25835317 Zhang, CH; Zheng, MW; Li, YP; Lin, XD; Huang, M; Zhong, L; Li, GB; Zhang, RJ; Lin, WT; Jiao, Y; Wu, XA; Yang, J; Xiang, R; Chen, LJ; Zhao, YL; Cheng, W; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50086441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50086441&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118737057 103985649 CHEMBL3426225 ZINC27650632 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50336870 CCn1nc(C#Cc2cc(ccc2C)C(=O)Nc2ccc(CN3CCN(C)CC3)c(c2)C(F)(F)F)c2c(N)ncnc12 InChI=1S/C30H31F3N8O/c1-4-41-28-26(27(34)35-18-36-28)25(38-41)10-8-20-15-21(6-5-19(20)2)29(42)37-23-9-7-22(24(16-23)30(31,32)33)17-40-13-11-39(3)12-14-40/h5-7,9,15-16,18H,4,11-14,17H2,1-3H3,(H,37,42)(H2,34,35,36) BNRXMSGHPVYSDK-UHFFFAOYSA-N 50086441 CHEMBL3426225::US10266537, Compound 3 Serine/threonine-protein kinase B-raf Homo sapiens 15 ChEMBL 10.1021/acs.jmedchem.5b00270 10.7270/Q2J38V91 25835317 Zhang, CH; Zheng, MW; Li, YP; Lin, XD; Huang, M; Zhong, L; Li, GB; Zhang, RJ; Lin, WT; Jiao, Y; Wu, XA; Yang, J; Xiang, R; Chen, LJ; Zhao, YL; Cheng, W; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50086441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50086441&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118737057 103985649 CHEMBL3426225 ZINC27650632 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334078 CC(=O)Nc1cccc(c1)-c1cncc(NCc2cc(C)n[nH]2)n1 InChI=1S/C17H18N6O/c1-11-6-15(23-22-11)8-19-17-10-18-9-16(21-17)13-4-3-5-14(7-13)20-12(2)24/h3-7,9-10H,8H2,1-2H3,(H,19,21)(H,20,24)(H,22,23) GIHLYUUIMBKART-UHFFFAOYSA-N 50180327 2-[(1,5-Dimethyl-1H-pyrazol-3-yl)methylamino]-6-(3-acetamidophenyl)pyrazine::CHEMBL382262 Serine/threonine-protein kinase B-raf Homo sapiens 14000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180327&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406750 104065414 CHEMBL382262 ZINC28567650 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334079 CC(=O)Nc1cccc(c1)-c1cncc(NCCc2ccccc2)n1 InChI=1S/C20H20N4O/c1-15(25)23-18-9-5-8-17(12-18)19-13-21-14-20(24-19)22-11-10-16-6-3-2-4-7-16/h2-9,12-14H,10-11H2,1H3,(H,22,24)(H,23,25) KPUDQOJMEHYWFH-UHFFFAOYSA-N 50180328 2-(Phenylethylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL372149 Serine/threonine-protein kinase B-raf Homo sapiens 45000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180328&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11544514 104065415 CHEMBL372149 ZINC13679283 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334080 CC(=O)Nc1cccc(c1)-c1cncc(Nc2nc(cs2)C(C)(C)C)n1 InChI=1S/C19H21N5OS/c1-12(25)21-14-7-5-6-13(8-14)15-9-20-10-17(22-15)24-18-23-16(11-26-18)19(2,3)4/h5-11H,1-4H3,(H,21,25)(H,22,23,24) JVRVIJGVFCOEMN-UHFFFAOYSA-N 50180329 2-(4-tert-Butylthiazol-2-ylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL381275 Serine/threonine-protein kinase B-raf Homo sapiens 20000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180329&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11494370 104065416 CHEMBL381275 ZINC13679268 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334081 CC(=O)Nc1cccc(c1)-c1cncc(Nc2cccc(Cl)c2)n1 InChI=1S/C18H15ClN4O/c1-12(24)21-15-6-2-4-13(8-15)17-10-20-11-18(23-17)22-16-7-3-5-14(19)9-16/h2-11H,1H3,(H,21,24)(H,22,23) IJTBMFYXAKZFBZ-UHFFFAOYSA-N 50180330 2-(3-Chlorophenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL201322 Serine/threonine-protein kinase B-raf Homo sapiens 8800 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180330&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11709835 104065417 CHEMBL201322 ZINC13679238 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334082 CC(=O)Nc1cccc(c1)-c1cncc(NCc2ccc3OCOc3c2)n1 InChI=1S/C20H18N4O3/c1-13(25)23-16-4-2-3-15(8-16)17-10-21-11-20(24-17)22-9-14-5-6-18-19(7-14)27-12-26-18/h2-8,10-11H,9,12H2,1H3,(H,22,24)(H,23,25) GPHPIMUYAQUIEO-UHFFFAOYSA-N 50180332 2-(3,4-Methylenedioxyphenylaminomethyl)-6-(3-acetamidophenyl)pyrazine::CHEMBL201576 Serine/threonine-protein kinase B-raf Homo sapiens 3800 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180332&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11660528 104065419 CHEMBL201576 ZINC13679272 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334083 CC(=O)Nc1cccc(c1)-c1cncc(NCc2cc(C)on2)n1 InChI=1S/C17H17N5O2/c1-11-6-15(22-24-11)8-19-17-10-18-9-16(21-17)13-4-3-5-14(7-13)20-12(2)23/h3-7,9-10H,8H2,1-2H3,(H,19,21)(H,20,23) UJOLEAOYRSZYCV-UHFFFAOYSA-N 50180333 2-[(5-Methyl-3-isoxazolyl)methylamino]-6-(3-acetamidophenyl)pyrazine::CHEMBL201625 Serine/threonine-protein kinase B-raf Homo sapiens 38000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180333&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11702547 104065420 CHEMBL201625 ZINC13679275 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334084 COc1cc(Nc2cncc(n2)-c2cccc(NC(C)=O)c2)cc(OC)c1 InChI=1S/C20H20N4O3/c1-13(25)22-15-6-4-5-14(7-15)19-11-21-12-20(24-19)23-16-8-17(26-2)10-18(9-16)27-3/h4-12H,1-3H3,(H,22,25)(H,23,24) MTTHTAYIMMMAOW-UHFFFAOYSA-N 50180331 2-(3,5-Dimethoxyphenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL425577 Serine/threonine-protein kinase B-raf Homo sapiens 3000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180331&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11574129 104065418 CHEMBL425577 ZINC13679232 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334085 COc1cc(Nc2cncc(n2)-c2cccc(NC(C)=O)c2)cc(OC)c1 InChI=1S/C20H20N4O3/c1-13(25)22-15-6-4-5-14(7-15)19-11-21-12-20(24-19)23-16-8-17(26-2)10-18(9-16)27-3/h4-12H,1-3H3,(H,22,25)(H,23,24) MTTHTAYIMMMAOW-UHFFFAOYSA-N 50180331 2-(3,5-Dimethoxyphenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL425577 Serine/threonine-protein kinase B-raf Homo sapiens 2700 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180331&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11574129 104065418 CHEMBL425577 ZINC13679232 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334086 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc3OCOc3c2)n1 InChI=1S/C19H16N4O3/c1-12(24)21-14-4-2-3-13(7-14)16-9-20-10-19(23-16)22-15-5-6-17-18(8-15)26-11-25-17/h2-10H,11H2,1H3,(H,21,24)(H,22,23) VCQYSCPNENRBFZ-UHFFFAOYSA-N 50180334 2-(3,4-Methylenedioxyphenylamino)-6-(3-acetamidophenyl)-pyrazine::CHEMBL371958 Serine/threonine-protein kinase B-raf Homo sapiens 32 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180334&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11501142 104065421 CHEMBL371958 ZINC13679252 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334087 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc3OC(F)(F)C(F)(F)Oc3c2)n1 InChI=1S/C20H14F4N4O3/c1-11(29)26-13-4-2-3-12(7-13)15-9-25-10-18(28-15)27-14-5-6-16-17(8-14)31-20(23,24)19(21,22)30-16/h2-10H,1H3,(H,26,29)(H,27,28) NFTWEOSEEWLMRF-UHFFFAOYSA-N 50180335 2-(2,2,3,3-Tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-ylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL373242 Serine/threonine-protein kinase B-raf Homo sapiens 39000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180335&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11590139 104065422 CHEMBL373242 ZINC13679258 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334088 COc1cc(Nc2cncc(n2)-c2cccc(NC(C)=O)c2)cc(OC)c1OC InChI=1S/C21H22N4O4/c1-13(26)23-15-7-5-6-14(8-15)17-11-22-12-20(25-17)24-16-9-18(27-2)21(29-4)19(10-16)28-3/h5-12H,1-4H3,(H,23,26)(H,24,25) XHHWYSOCWRJUGN-UHFFFAOYSA-N 25561 2,6-Disubstituted Pyrazine, 1::CHEMBL200114::N-(3-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}phenyl)acetamide Serine/threonine-protein kinase B-raf Homo sapiens 3500 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25561&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11682654 56412851 CHEMBL200114 ZINC13679218 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334089 COc1cc(CNc2cncc(n2)-c2cccc(NC(C)=O)c2)cc(OC)c1OC InChI=1S/C22H24N4O4/c1-14(27)25-17-7-5-6-16(10-17)18-12-23-13-21(26-18)24-11-15-8-19(28-2)22(30-4)20(9-15)29-3/h5-10,12-13H,11H2,1-4H3,(H,24,26)(H,25,27) LLXKKDSZHADWJG-UHFFFAOYSA-N 50180336 2-(3,4,5-Trimethoxybenzylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL199892 Serine/threonine-protein kinase B-raf Homo sapiens >100000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180336&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11704203 104065423 CHEMBL199892 ZINC13679291 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334090 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 46 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334091 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc3OCCOc3c2)n1 InChI=1S/C20H18N4O3/c1-13(25)22-15-4-2-3-14(9-15)17-11-21-12-20(24-17)23-16-5-6-18-19(10-16)27-8-7-26-18/h2-6,9-12H,7-8H2,1H3,(H,22,25)(H,23,24) TXTKXFOMRHZRLS-UHFFFAOYSA-N 50180337 2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-ylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL199833 Serine/threonine-protein kinase B-raf Homo sapiens 3000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180337&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11624720 104065424 CHEMBL199833 ZINC13679254 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334092 CC(=O)Nc1cccc(c1)-c1cncc(NCCCc2ccccc2)n1 InChI=1S/C21H22N4O/c1-16(26)24-19-11-5-10-18(13-19)20-14-22-15-21(25-20)23-12-6-9-17-7-3-2-4-8-17/h2-5,7-8,10-11,13-15H,6,9,12H2,1H3,(H,23,25)(H,24,26) NBTVCGJHKNPKQV-UHFFFAOYSA-N 50180338 2-(3-Phenylpropylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL200130 Serine/threonine-protein kinase B-raf Homo sapiens 33000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180338&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11602668 104065425 CHEMBL200130 ZINC13679285 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334093 COc1ccc(Nc2cncc(n2)-c2cccc(NC(C)=O)c2)cc1OC InChI=1S/C20H20N4O3/c1-13(25)22-15-6-4-5-14(9-15)17-11-21-12-20(24-17)23-16-7-8-18(26-2)19(10-16)27-3/h4-12H,1-3H3,(H,22,25)(H,23,24) VVMYJVKNHBSETM-UHFFFAOYSA-N 50180339 2-(3,4-Dimethoxyphenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL203093 Serine/threonine-protein kinase B-raf Homo sapiens 6400 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180339&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11588629 104065426 CHEMBL203093 ZINC13679234 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334094 CC(=O)Nc1cccc(c1)-c1cncc(NCCOc2ccccc2)n1 InChI=1S/C20H20N4O2/c1-15(25)23-17-7-5-6-16(12-17)19-13-21-14-20(24-19)22-10-11-26-18-8-3-2-4-9-18/h2-9,12-14H,10-11H2,1H3,(H,22,24)(H,23,25) UHEGFFPCYMLGKR-UHFFFAOYSA-N 50180340 2-Phenoxyethylamino-6-(3-acetamidophenyl)pyrazine::CHEMBL200964 Serine/threonine-protein kinase B-raf Homo sapiens 33000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180340&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11573823 104065427 CHEMBL200964 ZINC13679287 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334095 CC(=O)Nc1cccc(c1)-c1cncc(NCc2cc(C)n[nH]2)n1 InChI=1S/C17H18N6O/c1-11-6-15(23-22-11)8-19-17-10-18-9-16(21-17)13-4-3-5-14(7-13)20-12(2)24/h3-7,9-10H,8H2,1-2H3,(H,19,21)(H,20,24)(H,22,23) GIHLYUUIMBKART-UHFFFAOYSA-N 50180327 2-[(1,5-Dimethyl-1H-pyrazol-3-yl)methylamino]-6-(3-acetamidophenyl)pyrazine::CHEMBL382262 Serine/threonine-protein kinase B-raf Homo sapiens 18000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180327&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406750 104065414 CHEMBL382262 ZINC28567650 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334096 COc1cc(Nc2cncc(n2)-c2cccc(NC(C)=O)c2)cc(OC)c1OC InChI=1S/C21H22N4O4/c1-13(26)23-15-7-5-6-14(8-15)17-11-22-12-20(25-17)24-16-9-18(27-2)21(29-4)19(10-16)28-3/h5-12H,1-4H3,(H,23,26)(H,24,25) XHHWYSOCWRJUGN-UHFFFAOYSA-N 25561 2,6-Disubstituted Pyrazine, 1::CHEMBL200114::N-(3-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}phenyl)acetamide Serine/threonine-protein kinase B-raf Homo sapiens 3600 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25561&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11682654 56412851 CHEMBL200114 ZINC13679218 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334097 COc1cccc(Nc2cncc(n2)-c2cccc(NC(C)=O)c2)c1 InChI=1S/C19H18N4O2/c1-13(24)21-15-6-3-5-14(9-15)18-11-20-12-19(23-18)22-16-7-4-8-17(10-16)25-2/h3-12H,1-2H3,(H,21,24)(H,22,23) QLEZPLWRRGWYIU-UHFFFAOYSA-N 50180341 2-(3-Methoxyphenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL373006 Serine/threonine-protein kinase B-raf Homo sapiens 4800 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180341&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11667144 104065428 CHEMBL373006 ZINC13679226 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334098 COc1cc(CNc2cncc(n2)-c2cccc(NC(C)=O)c2)cc(OC)c1OC InChI=1S/C22H24N4O4/c1-14(27)25-17-7-5-6-16(10-17)18-12-23-13-21(26-18)24-11-15-8-19(28-2)22(30-4)20(9-15)29-3/h5-10,12-13H,11H2,1-4H3,(H,24,26)(H,25,27) LLXKKDSZHADWJG-UHFFFAOYSA-N 50180336 2-(3,4,5-Trimethoxybenzylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL199892 Serine/threonine-protein kinase B-raf Homo sapiens 37000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180336&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11704203 104065423 CHEMBL199892 ZINC13679291 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334099 CC(=O)Nc1cccc(c1)-c1cncc(NCc2ccoc2)n1 InChI=1S/C17H16N4O2/c1-12(22)20-15-4-2-3-14(7-15)16-9-18-10-17(21-16)19-8-13-5-6-23-11-13/h2-7,9-11H,8H2,1H3,(H,19,21)(H,20,22) NWZWUOACKDKPFB-UHFFFAOYSA-N 50180342 2-(3-Furylmethylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL199588 Serine/threonine-protein kinase B-raf Homo sapiens 33000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180342&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11645222 104065429 CHEMBL199588 ZINC13679295 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334100 CC(=O)Nc1cccc(c1)-c1cncc(NCCOc2ccccc2)n1 InChI=1S/C20H20N4O2/c1-15(25)23-17-7-5-6-16(12-17)19-13-21-14-20(24-19)22-10-11-26-18-8-3-2-4-9-18/h2-9,12-14H,10-11H2,1H3,(H,22,24)(H,23,25) UHEGFFPCYMLGKR-UHFFFAOYSA-N 50180340 2-Phenoxyethylamino-6-(3-acetamidophenyl)pyrazine::CHEMBL200964 Serine/threonine-protein kinase B-raf Homo sapiens 65000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180340&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11573823 104065427 CHEMBL200964 ZINC13679287 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334101 CC(=O)Nc1cccc(c1)-c1cncc(Nc2cccc3OC(F)(F)C(F)(F)Oc23)n1 InChI=1S/C20H14F4N4O3/c1-11(29)26-13-5-2-4-12(8-13)15-9-25-10-17(28-15)27-14-6-3-7-16-18(14)31-20(23,24)19(21,22)30-16/h2-10H,1H3,(H,26,29)(H,27,28) LDSWLRCAVNUBMQ-UHFFFAOYSA-N 50180343 CHEMBL199605::N-(3-(6-(2,2,3,3-Tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-ylamino)pyrazin-2-yl)phenyl)acetamide Serine/threonine-protein kinase B-raf Homo sapiens >100000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180343&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11633452 104065430 CHEMBL199605 ZINC13679262 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334102 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc3OC(F)(F)Oc3c2)n1 InChI=1S/C19H14F2N4O3/c1-11(26)23-13-4-2-3-12(7-13)15-9-22-10-18(25-15)24-14-5-6-16-17(8-14)28-19(20,21)27-16/h2-10H,1H3,(H,23,26)(H,24,25) RZVOBOMCZOXHTE-UHFFFAOYSA-N 50180345 2-(2,2-Difluorobenzo[d][1,3]dioxol-5-ylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL200075 Serine/threonine-protein kinase B-raf Homo sapiens 37000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180345&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11501869 104065432 CHEMBL200075 ZINC13679260 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334103 CC(=O)Nc1cccc(c1)-c1cncc(NCCCc2ccccc2)n1 InChI=1S/C21H22N4O/c1-16(26)24-19-11-5-10-18(13-19)20-14-22-15-21(25-20)23-12-6-9-17-7-3-2-4-8-17/h2-5,7-8,10-11,13-15H,6,9,12H2,1H3,(H,23,25)(H,24,26) NBTVCGJHKNPKQV-UHFFFAOYSA-N 50180338 2-(3-Phenylpropylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL200130 Serine/threonine-protein kinase B-raf Homo sapiens >100000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180338&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11602668 104065425 CHEMBL200130 ZINC13679285 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334104 CC(=O)Nc1cccc(c1)-c1cncc(NCc2cccc(F)c2)n1 InChI=1S/C19H17FN4O/c1-13(25)23-17-7-3-5-15(9-17)18-11-21-12-19(24-18)22-10-14-4-2-6-16(20)8-14/h2-9,11-12H,10H2,1H3,(H,22,24)(H,23,25) JHOWTFRMOUVWQN-UHFFFAOYSA-N 50180344 2-(3-Fluorophenylmethylamino)-6-(3'-acetamidophenyl)pyrazine::CHEMBL440761 Serine/threonine-protein kinase B-raf Homo sapiens 8000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180344&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11522875 104065431 CHEMBL440761 ZINC13679293 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334105 COc1cccc(Nc2cncc(n2)-c2cccc(NC(C)=O)c2)c1 InChI=1S/C19H18N4O2/c1-13(24)21-15-6-3-5-14(9-15)18-11-20-12-19(23-18)22-16-7-4-8-17(10-16)25-2/h3-12H,1-2H3,(H,21,24)(H,22,23) QLEZPLWRRGWYIU-UHFFFAOYSA-N 50180341 2-(3-Methoxyphenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL373006 Serine/threonine-protein kinase B-raf Homo sapiens 4000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180341&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11667144 104065428 CHEMBL373006 ZINC13679226 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334106 CC(=O)Nc1cccc(c1)-c1cncc(NCc2ccc(F)c(Cl)c2)n1 InChI=1S/C19H16ClFN4O/c1-12(26)24-15-4-2-3-14(8-15)18-10-22-11-19(25-18)23-9-13-5-6-17(21)16(20)7-13/h2-8,10-11H,9H2,1H3,(H,23,25)(H,24,26) DXCYGLXVGWPKEI-UHFFFAOYSA-N 50180347 2-(3-Chloro-4-fluorobenzylamino)-6-(3-acetamidophenyl)-pyrazine::CHEMBL274738 Serine/threonine-protein kinase B-raf Homo sapiens 99000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180347&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11501578 104065434 CHEMBL274738 ZINC13679297 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334107 CN(Nc1cncc(n1)-c1cccc(NC(C)=O)c1)c1ccccc1 InChI=1S/C19H19N5O/c1-14(25)21-16-8-6-7-15(11-16)18-12-20-13-19(22-18)23-24(2)17-9-4-3-5-10-17/h3-13H,1-2H3,(H,21,25)(H,22,23) DHWSDQAWLZEOQK-UHFFFAOYSA-N 50180346 2-(Phenyl-N-methylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL199805 Serine/threonine-protein kinase B-raf Homo sapiens 49600 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180346&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406731 104065433 CHEMBL199805 ZINC28566522 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334108 COc1ccc(Nc2cncc(n2)-c2cccc(NC(C)=O)c2)cc1OC InChI=1S/C20H20N4O3/c1-13(25)22-15-6-4-5-14(9-15)17-11-21-12-20(24-17)23-16-7-8-18(26-2)19(10-16)27-3/h4-12H,1-3H3,(H,22,25)(H,23,24) VVMYJVKNHBSETM-UHFFFAOYSA-N 50180339 2-(3,4-Dimethoxyphenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL203093 Serine/threonine-protein kinase B-raf Homo sapiens 1300 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180339&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11588629 104065426 CHEMBL203093 ZINC13679234 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334109 CC(=O)Nc1cccc(c1)-c1cncc(Nc2cccc(c2)-c2cnco2)n1 InChI=1S/C21H17N5O2/c1-14(27)24-17-6-2-4-15(8-17)19-10-22-12-21(26-19)25-18-7-3-5-16(9-18)20-11-23-13-28-20/h2-13H,1H3,(H,24,27)(H,25,26) NJENIOUMKVKNRM-UHFFFAOYSA-N 50180350 2-[3-(Oxazol-5-yl)phenylamino]-6-(3-acetamidophenyl)pyrazine::CHEMBL198244 Serine/threonine-protein kinase B-raf Homo sapiens 45000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180350&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11574273 104065437 CHEMBL198244 ZINC13679246 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334110 COc1ccc(Nc2cncc(n2)-c2cccc(NC(C)=O)c2)c(OC)c1 InChI=1S/C20H20N4O3/c1-13(25)22-15-6-4-5-14(9-15)18-11-21-12-20(24-18)23-17-8-7-16(26-2)10-19(17)27-3/h4-12H,1-3H3,(H,22,25)(H,23,24) MVRQJAIGNAEYLC-UHFFFAOYSA-N 50180351 2-(2,4-Dimethoxyphenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL201272 Serine/threonine-protein kinase B-raf Homo sapiens 8800 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180351&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11581360 104065438 CHEMBL201272 ZINC13679236 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334111 COc1ccc(Nc2cncc(n2)-c2cccc(NC(C)=O)c2)c(OC)c1 InChI=1S/C20H20N4O3/c1-13(25)22-15-6-4-5-14(9-15)18-11-21-12-20(24-18)23-17-8-7-16(26-2)10-19(17)27-3/h4-12H,1-3H3,(H,22,25)(H,23,24) MVRQJAIGNAEYLC-UHFFFAOYSA-N 50180351 2-(2,4-Dimethoxyphenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL201272 Serine/threonine-protein kinase B-raf Homo sapiens 21000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180351&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11581360 104065438 CHEMBL201272 ZINC13679236 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334112 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccccc2)n1 InChI=1S/C18H16N4O/c1-13(23)20-16-9-5-6-14(10-16)17-11-19-12-18(22-17)21-15-7-3-2-4-8-15/h2-12H,1H3,(H,20,23)(H,21,22) MKRMZWIJCMWBDU-UHFFFAOYSA-N 50180352 2-(Phenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL425576 Serine/threonine-protein kinase B-raf Homo sapiens 12000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180352&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11515006 104065439 CHEMBL425576 ZINC13679220 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334113 CC(=O)Nc1cccc(c1)-c1cncc(NCc2ccccn2)n1 InChI=1S/C18H17N5O/c1-13(24)22-15-7-4-5-14(9-15)17-11-19-12-18(23-17)21-10-16-6-2-3-8-20-16/h2-9,11-12H,10H2,1H3,(H,21,23)(H,22,24) KBTGWRVIMPDTFG-UHFFFAOYSA-N 50180348 2-(2-Pyridylmethylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL433992 Serine/threonine-protein kinase B-raf Homo sapiens >100000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180348&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11573300 104065435 CHEMBL433992 ZINC13679279 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334114 COc1ccc(OCCNc2cncc(n2)-c2cccc(NC(C)=O)c2)cc1 InChI=1S/C21H22N4O3/c1-15(26)24-17-5-3-4-16(12-17)20-13-22-14-21(25-20)23-10-11-28-19-8-6-18(27-2)7-9-19/h3-9,12-14H,10-11H2,1-2H3,(H,23,25)(H,24,26) GRJCMBQOXBJUJH-UHFFFAOYSA-N 50180349 2-(4-Methoxyphenyloxyethylamino)-6-(3-acetamidophenyl)-pyrazine::CHEMBL198400 Serine/threonine-protein kinase B-raf Homo sapiens 58000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180349&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11632277 104065436 CHEMBL198400 ZINC13679289 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334115 CN(Nc1cncc(n1)-c1cccc(NC(C)=O)c1)c1ccccc1 InChI=1S/C19H19N5O/c1-14(25)21-16-8-6-7-15(11-16)18-12-20-13-19(22-18)23-24(2)17-9-4-3-5-10-17/h3-13H,1-2H3,(H,21,25)(H,22,23) DHWSDQAWLZEOQK-UHFFFAOYSA-N 50180346 2-(Phenyl-N-methylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL199805 Serine/threonine-protein kinase B-raf Homo sapiens >100000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180346&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406731 104065433 CHEMBL199805 ZINC28566522 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334116 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc(cc2)N2CCOCC2)n1 InChI=1S/C22H23N5O2/c1-16(28)24-19-4-2-3-17(13-19)21-14-23-15-22(26-21)25-18-5-7-20(8-6-18)27-9-11-29-12-10-27/h2-8,13-15H,9-12H2,1H3,(H,24,28)(H,25,26) SSOSLWIJKQSITE-UHFFFAOYSA-N 50180354 2-(4-Morpholinophenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL383374 Serine/threonine-protein kinase B-raf Homo sapiens 2300 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180354&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11574625 104065441 CHEMBL383374 ZINC13679250 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334117 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc(OC(F)(F)F)cc2)n1 InChI=1S/C19H15F3N4O2/c1-12(27)24-15-4-2-3-13(9-15)17-10-23-11-18(26-17)25-14-5-7-16(8-6-14)28-19(20,21)22/h2-11H,1H3,(H,24,27)(H,25,26) PNBFEKVAJLXKGT-UHFFFAOYSA-N 50180355 2-[4-(Trifluoromethoxy)phenylamino]-6-(3-acetamidophenyl)-pyrazine::CHEMBL378600 Serine/threonine-protein kinase B-raf Homo sapiens 5200 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180355&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11639649 104065442 CHEMBL378600 ZINC13679242 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334121 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 6100 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334122 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)n1 InChI=1S/C22H23N5O4S/c1-16(28)24-19-4-2-3-17(13-19)21-14-23-15-22(26-21)25-18-5-7-20(8-6-18)32(29,30)27-9-11-31-12-10-27/h2-8,13-15H,9-12H2,1H3,(H,24,28)(H,25,26) ZVCMGYVZXOWATH-UHFFFAOYSA-N 50180357 2-[4-(Morpholinosulfonyl)phenylamino]-6-(3-acetamidophenyl)pyrazine::CHEMBL200080 Serine/threonine-protein kinase B-raf Homo sapiens 8800 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180357&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11546962 104065444 CHEMBL200080 ZINC13679248 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334123 CC(=O)Nc1cccc(c1)-c1cncc(Nc2cccc(OCCN)c2)n1 InChI=1S/C20H21N5O2/c1-14(26)23-16-5-2-4-15(10-16)19-12-22-13-20(25-19)24-17-6-3-7-18(11-17)27-9-8-21/h2-7,10-13H,8-9,21H2,1H3,(H,23,26)(H,24,25) ZKFXUGYLQAMRAD-UHFFFAOYSA-N 50180358 2-[3-(2-Aminoethoxy)phenylamino]-6-(3-acetamidophenyl)-pyrazine::CHEMBL199355 Serine/threonine-protein kinase B-raf Homo sapiens 3800 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180358&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11545064 104065445 CHEMBL199355 ZINC13679228 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334124 CC(=O)Nc1cccc(c1)-c1cncc(NCc2ccc(F)c(Cl)c2)n1 InChI=1S/C19H16ClFN4O/c1-12(26)24-15-4-2-3-14(8-15)18-10-22-11-19(25-18)23-9-13-5-6-17(21)16(20)7-13/h2-8,10-11H,9H2,1H3,(H,23,25)(H,24,26) DXCYGLXVGWPKEI-UHFFFAOYSA-N 50180347 2-(3-Chloro-4-fluorobenzylamino)-6-(3-acetamidophenyl)-pyrazine::CHEMBL274738 Serine/threonine-protein kinase B-raf Homo sapiens 27000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180347&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11501578 104065434 CHEMBL274738 ZINC13679297 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334125 CC(=O)Nc1cccc(c1)-c1cncc(NCc2ccccn2)n1 InChI=1S/C18H17N5O/c1-13(24)22-15-7-4-5-14(9-15)17-11-19-12-18(23-17)21-10-16-6-2-3-8-20-16/h2-9,11-12H,10H2,1H3,(H,21,23)(H,22,24) KBTGWRVIMPDTFG-UHFFFAOYSA-N 50180348 2-(2-Pyridylmethylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL433992 Serine/threonine-protein kinase B-raf Homo sapiens >100000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180348&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11573300 104065435 CHEMBL433992 ZINC13679279 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334126 CC(=O)Nc1cccc(c1)-c1cncc(Nc2cccc(OCCN)c2)n1 InChI=1S/C20H21N5O2/c1-14(26)23-16-5-2-4-15(10-16)19-12-22-13-20(25-19)24-17-6-3-7-18(11-17)27-9-8-21/h2-7,10-13H,8-9,21H2,1H3,(H,23,26)(H,24,25) ZKFXUGYLQAMRAD-UHFFFAOYSA-N 50180358 2-[3-(2-Aminoethoxy)phenylamino]-6-(3-acetamidophenyl)-pyrazine::CHEMBL199355 Serine/threonine-protein kinase B-raf Homo sapiens 5200 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180358&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11545064 104065445 CHEMBL199355 ZINC13679228 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334127 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc3COC(=O)c3c2)n1 InChI=1S/C20H16N4O3/c1-12(25)22-15-4-2-3-13(7-15)18-9-21-10-19(24-18)23-16-6-5-14-11-27-20(26)17(14)8-16/h2-10H,11H2,1H3,(H,22,25)(H,23,24) BOJDCYLXQYKJPO-UHFFFAOYSA-N 50180359 2-(3-Oxo-1,3-dihydroisobenzofuran-5-ylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL199811 Serine/threonine-protein kinase B-raf Homo sapiens 490 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180359&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11717449 104065446 CHEMBL199811 ZINC13679264 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334118 CC(=O)Nc1cccc(c1)-c1cncc(Nc2cc(Cl)nc(Cl)c2)n1 InChI=1S/C17H13Cl2N5O/c1-10(25)21-12-4-2-3-11(5-12)14-8-20-9-17(23-14)22-13-6-15(18)24-16(19)7-13/h2-9H,1H3,(H,21,25)(H,22,23,24) HBZLYXODYAMSLH-UHFFFAOYSA-N 50180353 2-(2,6-Dichloropyridin-4-ylamino)-6-(3-acetamidophenyl)-pyrazine::CHEMBL199948 Serine/threonine-protein kinase B-raf Homo sapiens 950 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180353&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11523639 104065440 CHEMBL199948 ZINC13679266 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334128 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc3OCCCOc3c2)n1 InChI=1S/C21H20N4O3/c1-14(26)23-16-5-2-4-15(10-16)18-12-22-13-21(25-18)24-17-6-7-19-20(11-17)28-9-3-8-27-19/h2,4-7,10-13H,3,8-9H2,1H3,(H,23,26)(H,24,25) SNZNFJNCSRVWJV-UHFFFAOYSA-N 50180356 2-(3,4-Dihydro-2H-benzo[b][1,4]dioxepin-7-ylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL199281 Serine/threonine-protein kinase B-raf Homo sapiens 3300 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180356&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11552560 104065443 CHEMBL199281 ZINC13679256 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334129 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc(OC(F)(F)F)cc2)n1 InChI=1S/C19H15F3N4O2/c1-12(27)24-15-4-2-3-13(9-15)17-10-23-11-18(26-17)25-14-5-7-16(8-6-14)28-19(20,21)22/h2-11H,1H3,(H,24,27)(H,25,26) PNBFEKVAJLXKGT-UHFFFAOYSA-N 50180355 2-[4-(Trifluoromethoxy)phenylamino]-6-(3-acetamidophenyl)-pyrazine::CHEMBL378600 Serine/threonine-protein kinase B-raf Homo sapiens 84000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180355&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11639649 104065442 CHEMBL378600 ZINC13679242 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334130 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc(cc2)N2CCOCC2)n1 InChI=1S/C22H23N5O2/c1-16(28)24-19-4-2-3-17(13-19)21-14-23-15-22(26-21)25-18-5-7-20(8-6-18)27-9-11-29-12-10-27/h2-8,13-15H,9-12H2,1H3,(H,24,28)(H,25,26) SSOSLWIJKQSITE-UHFFFAOYSA-N 50180354 2-(4-Morpholinophenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL383374 Serine/threonine-protein kinase B-raf Homo sapiens 10000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180354&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11574625 104065441 CHEMBL383374 ZINC13679250 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334131 CC(=O)Nc1cccc(c1)-c1cncc(Nc2cccc(O)c2)n1 InChI=1S/C18H16N4O2/c1-12(23)20-14-5-2-4-13(8-14)17-10-19-11-18(22-17)21-15-6-3-7-16(24)9-15/h2-11,24H,1H3,(H,20,23)(H,21,22) MFFDJRZIKKOABK-UHFFFAOYSA-N 50180360 2-(3-Hydroxyphenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL199394 Serine/threonine-protein kinase B-raf Homo sapiens 14000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180360&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11580569 104065447 CHEMBL199394 ZINC13679240 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334132 CC(=O)Nc1cccc(c1)-c1cncc(Nc2cccc3OC(F)(F)C(F)(F)Oc23)n1 InChI=1S/C20H14F4N4O3/c1-11(29)26-13-5-2-4-12(8-13)15-9-25-10-17(28-15)27-14-6-3-7-16-18(14)31-20(23,24)19(21,22)30-16/h2-10H,1H3,(H,26,29)(H,27,28) LDSWLRCAVNUBMQ-UHFFFAOYSA-N 50180343 CHEMBL199605::N-(3-(6-(2,2,3,3-Tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-ylamino)pyrazin-2-yl)phenyl)acetamide Serine/threonine-protein kinase B-raf Homo sapiens >100000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180343&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11633452 104065430 CHEMBL199605 ZINC13679262 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334133 CC(=O)Nc1cccc(c1)-c1cncc(Nc2cccc(Cl)c2)n1 InChI=1S/C18H15ClN4O/c1-12(24)21-15-6-2-4-13(8-15)17-10-20-11-18(23-17)22-16-7-3-5-14(19)9-16/h2-11H,1H3,(H,21,24)(H,22,23) IJTBMFYXAKZFBZ-UHFFFAOYSA-N 50180330 2-(3-Chlorophenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL201322 Serine/threonine-protein kinase B-raf Homo sapiens 1400 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180330&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11709835 104065417 CHEMBL201322 ZINC13679238 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334134 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)n1 InChI=1S/C22H23N5O4S/c1-16(28)24-19-4-2-3-17(13-19)21-14-23-15-22(26-21)25-18-5-7-20(8-6-18)32(29,30)27-9-11-31-12-10-27/h2-8,13-15H,9-12H2,1H3,(H,24,28)(H,25,26) ZVCMGYVZXOWATH-UHFFFAOYSA-N 50180357 2-[4-(Morpholinosulfonyl)phenylamino]-6-(3-acetamidophenyl)pyrazine::CHEMBL200080 Serine/threonine-protein kinase B-raf Homo sapiens 8300 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180357&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11546962 104065444 CHEMBL200080 ZINC13679248 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334135 COc1ccccc1Nc1cncc(n1)-c1cccc(NC(C)=O)c1 InChI=1S/C19H18N4O2/c1-13(24)21-15-7-5-6-14(10-15)17-11-20-12-19(23-17)22-16-8-3-4-9-18(16)25-2/h3-12H,1-2H3,(H,21,24)(H,22,23) DTNPANCCJJMVSB-UHFFFAOYSA-N 50180361 2-(2-Methoxyphenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL201023 Serine/threonine-protein kinase B-raf Homo sapiens 74000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180361&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11660026 104065448 CHEMBL201023 ZINC13679224 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334136 CC(=O)Nc1cccc(c1)-c1cncc(NCc2ccccc2)n1 InChI=1S/C19H18N4O/c1-14(24)22-17-9-5-8-16(10-17)18-12-20-13-19(23-18)21-11-15-6-3-2-4-7-15/h2-10,12-13H,11H2,1H3,(H,21,23)(H,22,24) APNYMHFAZCCZRG-UHFFFAOYSA-N 50180363 2-(Benzylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL199800 Serine/threonine-protein kinase B-raf Homo sapiens 18000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180363&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11631107 104065450 CHEMBL199800 ZINC13679281 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334137 COc1ccc(OCCNc2cncc(n2)-c2cccc(NC(C)=O)c2)cc1 InChI=1S/C21H22N4O3/c1-15(26)24-17-5-3-4-16(12-17)20-13-22-14-21(25-20)23-10-11-28-19-8-6-18(27-2)7-9-19/h3-9,12-14H,10-11H2,1-2H3,(H,23,25)(H,24,26) GRJCMBQOXBJUJH-UHFFFAOYSA-N 50180349 2-(4-Methoxyphenyloxyethylamino)-6-(3-acetamidophenyl)-pyrazine::CHEMBL198400 Serine/threonine-protein kinase B-raf Homo sapiens 38000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180349&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11632277 104065436 CHEMBL198400 ZINC13679289 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334119 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc3OCCOc3c2)n1 InChI=1S/C20H18N4O3/c1-13(25)22-15-4-2-3-14(9-15)17-11-21-12-20(24-17)23-16-5-6-18-19(10-16)27-8-7-26-18/h2-6,9-12H,7-8H2,1H3,(H,22,25)(H,23,24) TXTKXFOMRHZRLS-UHFFFAOYSA-N 50180337 2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-ylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL199833 Serine/threonine-protein kinase B-raf Homo sapiens 5400 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180337&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11624720 104065424 CHEMBL199833 ZINC13679254 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334138 COc1ccc(Nc2cncc(n2)-c2cccc(NC(C)=O)c2)cc1 InChI=1S/C19H18N4O2/c1-13(24)21-16-5-3-4-14(10-16)18-11-20-12-19(23-18)22-15-6-8-17(25-2)9-7-15/h3-12H,1-2H3,(H,21,24)(H,22,23) OGQIXTVTCCTJOB-UHFFFAOYSA-N 50180362 CHEMBL199798::N-(3-(6-(4-methoxyphenylamino)pyrazin-2-yl)phenyl)acetamide Serine/threonine-protein kinase B-raf Homo sapiens 26000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180362&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11551727 104065449 CHEMBL199798 ZINC13679230 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334120 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc3OCCCOc3c2)n1 InChI=1S/C21H20N4O3/c1-14(26)23-16-5-2-4-15(10-16)18-12-22-13-21(25-18)24-17-6-7-19-20(11-17)28-9-3-8-27-19/h2,4-7,10-13H,3,8-9H2,1H3,(H,23,26)(H,24,25) SNZNFJNCSRVWJV-UHFFFAOYSA-N 50180356 2-(3,4-Dihydro-2H-benzo[b][1,4]dioxepin-7-ylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL199281 Serine/threonine-protein kinase B-raf Homo sapiens 4500 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180356&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11552560 104065443 CHEMBL199281 ZINC13679256 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334139 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccccc2)n1 InChI=1S/C18H16N4O/c1-13(23)20-16-9-5-6-14(10-16)17-11-19-12-18(22-17)21-15-7-3-2-4-8-15/h2-12H,1H3,(H,20,23)(H,21,22) MKRMZWIJCMWBDU-UHFFFAOYSA-N 50180352 2-(Phenylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL425576 Serine/threonine-protein kinase B-raf Homo sapiens 7900 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180352&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11515006 104065439 CHEMBL425576 ZINC13679220 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334140 CC(=O)Nc1cccc(c1)-c1cncc(NCc2ccc3OCCOc3c2)n1 InChI=1S/C21H20N4O3/c1-14(26)24-17-4-2-3-16(10-17)18-12-22-13-21(25-18)23-11-15-5-6-19-20(9-15)28-8-7-27-19/h2-6,9-10,12-13H,7-8,11H2,1H3,(H,23,25)(H,24,26) RICRNXHHSBGKSW-UHFFFAOYSA-N 50180365 2-(2,3-Dehydro-1,4-benzodioxin-6-methylamino)-6-(3'-acetamidophenyl)pyrazine::CHEMBL370112 Serine/threonine-protein kinase B-raf Homo sapiens 34000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180365&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11552561 104065452 CHEMBL370112 ZINC13679270 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334141 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc3COC(=O)c3c2)n1 InChI=1S/C20H16N4O3/c1-12(25)22-15-4-2-3-13(7-15)18-9-21-10-19(24-18)23-16-6-5-14-11-27-20(26)17(14)8-16/h2-10H,11H2,1H3,(H,22,25)(H,23,24) BOJDCYLXQYKJPO-UHFFFAOYSA-N 50180359 2-(3-Oxo-1,3-dihydroisobenzofuran-5-ylamino)-6-(3-acetamidophenyl)pyrazine::CHEMBL199811 Serine/threonine-protein kinase B-raf Homo sapiens 740 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180359&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11717449 104065446 CHEMBL199811 ZINC13679264 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334142 CC(=O)Nc1cccc(c1)-c1cncc(NCc2cc(C)on2)n1 InChI=1S/C17H17N5O2/c1-11-6-15(22-24-11)8-19-17-10-18-9-16(21-17)13-4-3-5-14(7-13)20-12(2)23/h3-7,9-10H,8H2,1-2H3,(H,19,21)(H,20,23) UJOLEAOYRSZYCV-UHFFFAOYSA-N 50180333 2-[(5-Methyl-3-isoxazolyl)methylamino]-6-(3-acetamidophenyl)pyrazine::CHEMBL201625 Serine/threonine-protein kinase B-raf Homo sapiens 4200 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180333&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11702547 104065420 CHEMBL201625 ZINC13679275 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334143 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc(F)c(Cl)c2)n1 InChI=1S/C18H14ClFN4O/c1-11(25)22-13-4-2-3-12(7-13)17-9-21-10-18(24-17)23-14-5-6-16(20)15(19)8-14/h2-10H,1H3,(H,22,25)(H,23,24) GXUCGIAWJYEQOX-UHFFFAOYSA-N 50180364 2-(3-Chloro-4-fluorophenylamino)-6-(3-acetamidophenyl)-pyrazine::CHEMBL198348 Serine/threonine-protein kinase B-raf Homo sapiens >100000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180364&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11681939 104065451 CHEMBL198348 ZINC13679244 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334144 CC(=O)Nc1cccc(c1)-c1cncc(Nc2cccc(c2)-c2cnco2)n1 InChI=1S/C21H17N5O2/c1-14(27)24-17-6-2-4-15(8-17)19-10-22-12-21(26-19)25-18-7-3-5-16(9-18)20-11-23-13-28-20/h2-13H,1H3,(H,24,27)(H,25,26) NJENIOUMKVKNRM-UHFFFAOYSA-N 50180350 2-[3-(Oxazol-5-yl)phenylamino]-6-(3-acetamidophenyl)pyrazine::CHEMBL198244 Serine/threonine-protein kinase B-raf Homo sapiens 790 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180350&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11574273 104065437 CHEMBL198244 ZINC13679246 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50334145 CC(=O)Nc1cccc(c1)-c1cncc(Nc2ccc3OCOc3c2)n1 InChI=1S/C19H16N4O3/c1-12(24)21-14-4-2-3-13(7-14)16-9-20-10-19(23-16)22-15-5-6-17-18(8-15)26-11-25-17/h2-10H,11H2,1H3,(H,21,24)(H,22,23) VCQYSCPNENRBFZ-UHFFFAOYSA-N 50180334 2-(3,4-Methylenedioxyphenylamino)-6-(3-acetamidophenyl)-pyrazine::CHEMBL371958 Serine/threonine-protein kinase B-raf Homo sapiens 10000 ChEMBL 10.1021/jm050983g 10.7270/Q2KD1XH9 16392826 Niculescu-Duvaz, I; Roman, E; Whittaker, SR; Friedlos, F; Kirk, R; Scanlon, IJ; Davies, LC; Niculescu-Duvaz, D; Marais, R; Springer, CJ Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180334&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11501142 104065421 CHEMBL371958 ZINC13679252 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348649 Fc1ccc(cc1)-c1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccnc2)c1F InChI=1S/C32H35F2N5O5/c1-43-18-26-27(29(40)44-2)28(20-8-11-24(33)25(34)16-20)39(31(42)37-26)30(41)36-22-9-10-23(17-22)38-14-12-32(19-35,13-15-38)21-6-4-3-5-7-21/h3-8,11,16,22-23,28H,9-10,12-15,17-18H2,1-2H3,(H,36,41)(H,37,42)/t22?,23-,28-/m0/s1 UMVYPFAJDLQOIO-POYSAHEBSA-N 50091712 CHEMBL3582400 Serine/threonine-protein kinase B-raf Homo sapiens 11 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091712&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179535 103989942 CHEMBL3582400 ZINC29551794 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348650 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1C#Cc1cnc2[nH]nc(-c3ccc(Cl)cc3)c2c1 InChI=1S/C25H14ClF2N5O2S/c26-17-6-4-16(5-7-17)24-20-12-15(13-30-25(20)32-31-24)3-8-19-21(27)9-10-22(23(19)28)33-36(34,35)18-2-1-11-29-14-18/h1-2,4-7,9-14,33H,(H,30,31,32) HJYQHYRYGCMEJS-UHFFFAOYSA-N 50091762 CHEMBL3582399 Serine/threonine-protein kinase B-raf Homo sapiens 21 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091762&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179534 318473143 CHEMBL3582399 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348651 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1C#Cc1cnc2[nH]nc(-c3cccc(Cl)c3)c2c1 InChI=1S/C25H14ClF2N5O2S/c26-17-4-1-3-16(12-17)24-20-11-15(13-30-25(20)32-31-24)6-7-19-21(27)8-9-22(23(19)28)33-36(34,35)18-5-2-10-29-14-18/h1-5,8-14,33H,(H,30,31,32) GVNURFFMXXNZAQ-UHFFFAOYSA-N 50091763 CHEMBL3582398 Serine/threonine-protein kinase B-raf Homo sapiens 107 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091763&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179533 318473144 CHEMBL3582398 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348652 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1C#Cc1cnc2[nH]nc(-c3ccccc3Cl)c2c1 InChI=1S/C25H14ClF2N5O2S/c26-20-6-2-1-5-17(20)24-19-12-15(13-30-25(19)32-31-24)7-8-18-21(27)9-10-22(23(18)28)33-36(34,35)16-4-3-11-29-14-16/h1-6,9-14,33H,(H,30,31,32) YBBCRBQMANVTPM-UHFFFAOYSA-N 50091764 CHEMBL3582397 Serine/threonine-protein kinase B-raf Homo sapiens 131 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091764&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179532 318473145 CHEMBL3582397 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348653 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1C#Cc1cnc2[nH]nc(-c3ccncc3)c2c1 InChI=1S/C24H14F2N6O2S/c25-20-5-6-21(32-35(33,34)17-2-1-9-28-14-17)22(26)18(20)4-3-15-12-19-23(16-7-10-27-11-8-16)30-31-24(19)29-13-15/h1-2,5-14,32H,(H,29,30,31) XDTVEDUDDFICMG-UHFFFAOYSA-N 50091765 CHEMBL3582396 Serine/threonine-protein kinase B-raf Homo sapiens 3.0 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091765&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179531 318473146 CHEMBL3582396 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348655 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1C#Cc1cnc2[nH]nc(-c3ccccc3)c2c1 InChI=1S/C8H17N3O2/c9-4-2-1-3-7(8(12)13)11-6-5-10/h5,7,10-11H,1-4,6,9H2,(H,12,13)/t7-/m0/s1 NNRMAICNBIUGOW-ZETCQYMHSA-N 50091796 CHEMBL3582395 Serine/threonine-protein kinase B-raf Homo sapiens 16 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091796&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179530 103990022 CHEMBL3582395 ZINC26158331 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348657 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1C#Cc1cnc2[nH]nc(C3CC3)c2c1 InChI=1S/C22H15F2N5O2S/c23-18-7-8-19(29-32(30,31)15-2-1-9-25-12-15)20(24)16(18)6-3-13-10-17-21(14-4-5-14)27-28-22(17)26-11-13/h1-2,7-12,14,29H,4-5H2,(H,26,27,28) QHFQFWYLROSXCZ-UHFFFAOYSA-N 50091819 CHEMBL3582394 Serine/threonine-protein kinase B-raf Homo sapiens 10.0 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091819&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179529 318473147 CHEMBL3582394 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348659 Cc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccnc2)c1F InChI=1S/C20H13F2N5O2S/c1-12-16-9-13(10-24-20(16)26-25-12)4-5-15-17(21)6-7-18(19(15)22)27-30(28,29)14-3-2-8-23-11-14/h2-3,6-11,27H,1H3,(H,24,25,26) XGYFNELDYNKIEO-UHFFFAOYSA-N 50091820 CHEMBL3582393 Serine/threonine-protein kinase B-raf Homo sapiens 25 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091820&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179528 318473148 CHEMBL3582393 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348661 CCOc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccnc2)c1F InChI=1S/C21H15F2N5O3S/c1-2-31-21-16-10-13(11-25-20(16)26-27-21)5-6-15-17(22)7-8-18(19(15)23)28-32(29,30)14-4-3-9-24-12-14/h3-4,7-12,28H,2H2,1H3,(H,25,26,27) PNHLZOKSEBWVOX-UHFFFAOYSA-N 50091863 CHEMBL3582392 Serine/threonine-protein kinase B-raf Homo sapiens 122 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091863&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179527 318473149 CHEMBL3582392 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348662 COc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccnc2)c1F InChI=1S/C20H13F2N5O3S/c1-30-20-15-9-12(10-24-19(15)25-26-20)4-5-14-16(21)6-7-17(18(14)22)27-31(28,29)13-3-2-8-23-11-13/h2-3,6-11,27H,1H3,(H,24,25,26) XFXIISXNIPIZIZ-UHFFFAOYSA-N 50091864 CHEMBL3582391 Serine/threonine-protein kinase B-raf Homo sapiens 17 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091864&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179526 318473150 CHEMBL3582391 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348663 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1C#Cc1cnc2ccnn2c1 InChI=1S/C19H11F2N5O2S/c20-16-5-6-17(25-29(27,28)14-2-1-8-22-11-14)19(21)15(16)4-3-13-10-23-18-7-9-24-26(18)12-13/h1-2,5-12,25H CBGJZIAUYLUGFE-UHFFFAOYSA-N 50091865 CHEMBL3582390 Serine/threonine-protein kinase B-raf Homo sapiens 533 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091865&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179525 318473151 CHEMBL3582390 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348664 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1C#Cc1ccc2[nH]ncc2c1 InChI=1S/C20H12F2N4O2S/c21-17-6-8-19(26-29(27,28)15-2-1-9-23-12-15)20(22)16(17)5-3-13-4-7-18-14(10-13)11-24-25-18/h1-2,4,6-12,26H,(H,24,25) OHFQSPNVOAYQQX-UHFFFAOYSA-N 50091866 CHEMBL3582389 Serine/threonine-protein kinase B-raf Homo sapiens 4310 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091866&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179524 318473152 CHEMBL3582389 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348665 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1C#Cc1cnc2[nH]ccc2c1 InChI=1S/C27H34N2O4S/c1-3-18(2)23(34)24(30)29-27(15-7-8-16-27)26(33)28-22(25(31)32)17-19-11-13-21(14-12-19)20-9-5-4-6-10-20/h4-6,9-14,18,22-23,34H,3,7-8,15-17H2,1-2H3,(H,28,33)(H,29,30)(H,31,32)/t18?,22-,23+/m0/s1 OGXZPPQKOPSYNJ-AMHZRHSASA-N 50091881 CHEMBL3582388 Serine/threonine-protein kinase B-raf Homo sapiens 48 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091881&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179523 103990101 CHEMBL3582388 ZINC26158992 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348666 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1C#Cc1cnc2[nH]ncc2c1 InChI=1S/C19H11F2N5O2S/c20-16-5-6-17(26-29(27,28)14-2-1-7-22-11-14)18(21)15(16)4-3-12-8-13-10-24-25-19(13)23-9-12/h1-2,5-11,26H,(H,23,24,25) SSOPSBQSYPGIAA-UHFFFAOYSA-N 50091957 CHEMBL3582387 Serine/threonine-protein kinase B-raf Homo sapiens 51 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091957&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179522 318473153 CHEMBL3582387 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348667 Fc1ccc(NS(=O)(=O)c2ccccn2)c(F)c1C#Cc1cnc2[nH]ncc2c1 InChI=1S/C19H11F2N5O2S/c20-15-6-7-16(26-29(27,28)17-3-1-2-8-22-17)18(21)14(15)5-4-12-9-13-11-24-25-19(13)23-10-12/h1-3,6-11,26H,(H,23,24,25) IQMAIRGDVISVMU-UHFFFAOYSA-N 50091974 CHEMBL3582386 Serine/threonine-protein kinase B-raf Homo sapiens 593 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091974&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179521 103990193 CHEMBL3582386 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348668 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(F)c(C#Cc2cnc3[nH]ncc3c2)c1F InChI=1S/C20H11F3N4O2S/c21-14-2-4-15(5-3-14)30(28,29)27-18-8-7-17(22)16(19(18)23)6-1-12-9-13-11-25-26-20(13)24-10-12/h2-5,7-11,27H,(H,24,25,26) OVZUWMSLWUONJX-UHFFFAOYSA-N 50092010 CHEMBL3582385 Serine/threonine-protein kinase B-raf Homo sapiens 917 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092010&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179520 318473154 CHEMBL3582385 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348670 Fc1cccc(c1)S(=O)(=O)Nc1ccc(F)c(C#Cc2cnc3[nH]ncc3c2)c1F InChI=1S/C20H11F3N4O2S/c21-14-2-1-3-15(9-14)30(28,29)27-18-7-6-17(22)16(19(18)23)5-4-12-8-13-11-25-26-20(13)24-10-12/h1-3,6-11,27H,(H,24,25,26) HBJGQDFVZLTVDA-UHFFFAOYSA-N 50092011 CHEMBL3582384 Serine/threonine-protein kinase B-raf Homo sapiens 68 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092011&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179519 318473155 CHEMBL3582384 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348671 Fc1ccccc1S(=O)(=O)Nc1ccc(F)c(C#Cc2cnc3[nH]ncc3c2)c1F InChI=1S/C20H11F3N4O2S/c21-15-7-8-17(27-30(28,29)18-4-2-1-3-16(18)22)19(23)14(15)6-5-12-9-13-11-25-26-20(13)24-10-12/h1-4,7-11,27H,(H,24,25,26) ZSNCKPLYEUNIMY-UHFFFAOYSA-N 50092012 CHEMBL3582383 Serine/threonine-protein kinase B-raf Homo sapiens 177 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092012&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179518 318473156 CHEMBL3582383 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348672 Fc1ccc(NS(=O)(=O)c2ccccc2)c(F)c1C#Cc1cnc2[nH]ncc2c1 InChI=1S/C20H12F2N4O2S/c21-17-8-9-18(26-29(27,28)15-4-2-1-3-5-15)19(22)16(17)7-6-13-10-14-12-24-25-20(14)23-11-13/h1-5,8-12,26H,(H,23,24,25) XWZBNSFNTCQVII-UHFFFAOYSA-N 50092013 CHEMBL3582382 Serine/threonine-protein kinase B-raf Homo sapiens 149 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092013&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179517 318473157 CHEMBL3582382 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348674 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 33 ChEMBL 10.1021/acsmedchemlett.5b00039 10.7270/Q26W9CT5 26005530 Li, Y; Cheng, H; Zhang, Z; Zhuang, X; Luo, J; Long, H; Zhou, Y; Xu, Y; Taghipouran, R; Li, D; Patterson, A; Smaill, J; Tu, Z; Wu, D; Ren, X; Ding, K Guangzhou Institutes of Biomedicine and Health http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50348987 N#Cc1ccc(cc1)-c1cnc2ccc(NCc3ccccc3)nn12 InChI=1S/C20H15N5/c21-12-15-6-8-17(9-7-15)18-14-23-20-11-10-19(24-25(18)20)22-13-16-4-2-1-3-5-16/h1-11,14H,13H2,(H,22,24) OXQTXNVWTNDAQF-UHFFFAOYSA-N 50092080 CHEMBL3582427 Serine/threonine-protein kinase B-raf Homo sapiens 2500 ChEMBL 10.1021/acsmedchemlett.5b00050 10.7270/Q2TM7CW4 26005534 Choi, HS; Rucker, PV; Wang, Z; Fan, Y; Albaugh, P; Chopiuk, G; Gessier, F; Sun, F; Adrian, F; Liu, G; Hood, T; Li, N; Jia, Y; Che, J; McCormack, S; Li, A; Li, J; Steffy, A; Culazzo, A; Tompkins, C; Phung, V; Kreusch, A; Lu, M; Hu, B; Chaudhary, A; Prashad, M; Tuntland, T; Liu, B; Harris, J; Seidel, HM; Loren, J; Molteni, V Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092080&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 4EJ 4YMJ 122179540 103990292 CHEMBL3582427 ZINC34800649 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50349037 OC1CCN(CC1)c1cc(ccn1)-c1cnc2ccc(nn12)N1CCC[C@@H]1c1cccc(F)c1 InChI=1S/C26H27FN6O/c27-20-4-1-3-18(15-20)22-5-2-12-32(22)25-7-6-24-29-17-23(33(24)30-25)19-8-11-28-26(16-19)31-13-9-21(34)10-14-31/h1,3-4,6-8,11,15-17,21-22,34H,2,5,9-10,12-14H2/t22-/m1/s1 QSGGLLCPVRJDDE-JOCHJYFZSA-N 50092081 CHEMBL3582442 Serine/threonine-protein kinase B-raf Homo sapiens 5900 ChEMBL 10.1021/acsmedchemlett.5b00050 10.7270/Q2TM7CW4 26005534 Choi, HS; Rucker, PV; Wang, Z; Fan, Y; Albaugh, P; Chopiuk, G; Gessier, F; Sun, F; Adrian, F; Liu, G; Hood, T; Li, N; Jia, Y; Che, J; McCormack, S; Li, A; Li, J; Steffy, A; Culazzo, A; Tompkins, C; Phung, V; Kreusch, A; Lu, M; Hu, B; Chaudhary, A; Prashad, M; Tuntland, T; Liu, B; Harris, J; Seidel, HM; Loren, J; Molteni, V Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092081&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179548 103990293 CHEMBL3582442 ZINC34800643 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50349038 OC(=O)CN1CCN(CC1)c1cc(ccn1)-c1cnc2ccc(nn12)N1CCC[C@@H]1c1cccc(F)c1 InChI=1S/C27H28FN7O2/c28-21-4-1-3-19(15-21)22-5-2-10-34(22)25-7-6-24-30-17-23(35(24)31-25)20-8-9-29-26(16-20)33-13-11-32(12-14-33)18-27(36)37/h1,3-4,6-9,15-17,22H,2,5,10-14,18H2,(H,36,37)/t22-/m1/s1 UQKLTKAHTNLXPA-JOCHJYFZSA-N 50092082 CHEMBL3582441 Serine/threonine-protein kinase B-raf Homo sapiens 6200 ChEMBL 10.1021/acsmedchemlett.5b00050 10.7270/Q2TM7CW4 26005534 Choi, HS; Rucker, PV; Wang, Z; Fan, Y; Albaugh, P; Chopiuk, G; Gessier, F; Sun, F; Adrian, F; Liu, G; Hood, T; Li, N; Jia, Y; Che, J; McCormack, S; Li, A; Li, J; Steffy, A; Culazzo, A; Tompkins, C; Phung, V; Kreusch, A; Lu, M; Hu, B; Chaudhary, A; Prashad, M; Tuntland, T; Liu, B; Harris, J; Seidel, HM; Loren, J; Molteni, V Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092082&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122179547 103990294 CHEMBL3582441 ZINC34800639 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358803 CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C InChI=1S/C18H13N3O5/c22-14(23)5-4-10-8-21-13-7-12-9(6-15(24)25)2-1-3-11(12)16(13)20-18(26)17(21)19-10/h1-5,8H,6-7H2,(H,20,26)(H,22,23)(H,24,25)/b5-4+ UIJRICRAFILDOG-SNAWJCMRSA-N 50096279 CHEMBL3577124 Serine/threonine-protein kinase B-raf Homo sapiens 37 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096279&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 4Z5 5C9C 71721540 103993832 CHEMBL3577124 ZINC00022478 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358804 CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C InChI=1S/C22H17N3O2/c1-27-20-12-5-4-11-19(20)25-21(14-13-16-8-6-7-15-23-16)24-18-10-3-2-9-17(18)22(25)26/h2-15H,1H3/b14-13+ WJNBQLVNPARPAK-BUHFOSPRSA-N 50096323 CHEMBL3577123 Serine/threonine-protein kinase B-raf Homo sapiens 27 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096323&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89814000 103993876 CHEMBL3577123 ZINC05249767 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358805 CNc1cc2nc(C)c(cc2cn1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C InChI=1S/C26H22ClFN4O/c27-21-8-2-3-9-23(21)32-25(30-22-13-11-18(28)17-20(22)26(32)33)14-12-19-7-6-10-24(29-19)31-15-4-1-5-16-31/h2-3,6-14,17H,1,4-5,15-16H2/b14-12+ UCNQXJWFRZSRRU-WYMLVPIESA-N 50096324 CHEMBL3577121 Serine/threonine-protein kinase B-raf Homo sapiens 47 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096324&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71736864 103993877 CHEMBL3577121 ZINC29479291 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358806 CNc1cc2nc(C)c(cc2cn1)-c1ccc(F)c(NC(=O)NCCC(C)(C)C)c1 InChI=1S/C22H16ClN3O/c1-15-6-2-3-8-20(15)26-21(12-10-17-7-4-5-13-24-17)25-19-14-16(23)9-11-18(19)22(26)27/h2-14H,1H3/b12-10+ IRSLFBOEKZDCQE-ZRDIBKRKSA-N 50096325 CHEMBL3577120 Serine/threonine-protein kinase B-raf Homo sapiens 82 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096325&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71736390 103993878 CHEMBL3577120 ZINC29479778 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358807 CNc1ncc2cc(c(C)nc2n1)-c1ccc(F)c(NC(=O)NCCC(C)(C)C)c1 InChI=1S/C22H16ClN3O/c1-15-6-2-3-8-20(15)26-21(12-10-17-7-4-5-13-24-17)25-19-11-9-16(23)14-18(19)22(26)27/h2-14H,1H3/b12-10+ VAIRGGJNURCERD-ZRDIBKRKSA-N 50096328 CHEMBL3577119 Serine/threonine-protein kinase B-raf Homo sapiens 110 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096328&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71730951 103993881 CHEMBL3577119 ZINC29479194 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358808 CNc1cc2nc(C)c(cc2cn1)-c1cc(NC(=O)NCCC(C)(C)C)ccc1C InChI=1S/C22H16ClN3O/c1-15-7-2-3-11-19(15)26-20(13-12-16-8-4-5-14-24-16)25-21-17(22(26)27)9-6-10-18(21)23/h2-14H,1H3/b13-12+ QZLRYCZRJNTIGT-OUKQBFOZSA-N 50096329 CHEMBL3577118 Serine/threonine-protein kinase B-raf Homo sapiens 140 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096329&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71736552 103993882 CHEMBL3577118 ZINC29479671 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358809 CNc1cc2nc(C)c(cc2cn1)-c1cc(NC(=O)NC[C@@H](O)C(C)(C)C)c(F)cc1C InChI=1S/C22H13ClFN3O3/c23-16-5-1-2-7-19(16)27-20(11-9-14-4-3-6-18(25-14)22(29)30)26-17-10-8-13(24)12-15(17)21(27)28/h1-12H,(H,29,30)/b11-9+ PXJPTTIMVOXZBL-PKNBQFBNSA-N 50096330 CHEMBL3577117 Serine/threonine-protein kinase B-raf Homo sapiens 22 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096330&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89827799 103993883 CHEMBL3577117 ZINC29476023 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358810 CCn1c2cc(NC)ncc2cc(-c2cc(NC(=O)NCCC(C)(C)C)c(F)cc2C)c1=O InChI=1S/C21H14ClN3O/c22-17-9-2-4-11-19(17)25-20(13-12-15-7-5-6-14-23-15)24-18-10-3-1-8-16(18)21(25)26/h1-14H/b13-12+ GFIAVWYCWQNCLS-OUKQBFOZSA-N 50096331 CHEMBL3577116 Serine/threonine-protein kinase B-raf Homo sapiens 40 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096331&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122177478 103993884 CHEMBL3577116 ZINC04450431 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358811 CCn1c2cc(NC)ncc2cc(-c2ccc(F)c(NC(=O)Nc3cc(no3)C(C)(C)C)c2)c1=O InChI=1S/C22H15ClFN3O2/c23-18-6-1-2-7-20(18)27-21(11-9-15-4-3-5-16(13-28)25-15)26-19-10-8-14(24)12-17(19)22(27)29/h1-12,28H,13H2/b11-9+ GCRARKBYMYFDTH-PKNBQFBNSA-N 50096332 CHEMBL3577115 Serine/threonine-protein kinase B-raf Homo sapiens 96 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096332&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 69037249 103993885 CHEMBL3577115 ZINC29480759 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358812 CNc1cc2n([C@H]3CCOC3)c(=O)c(cc2cn1)-c1ccc(F)c(NC(=O)Nc2cc(no2)C(C)(C)C)c1 InChI=1S/C21H13F2N3O/c22-14-8-10-18-16(13-14)21(27)26(19-7-2-1-6-17(19)23)20(25-18)11-9-15-5-3-4-12-24-15/h1-13H/b11-9+ NKLRLPLSEJDIIC-PKNBQFBNSA-N 50096333 CHEMBL3577114 Serine/threonine-protein kinase B-raf Homo sapiens 6.8 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096333&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122177477 103993886 CHEMBL3577114 ZINC29481930 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358813 CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29) BFSMGDJOXZAERB-UHFFFAOYSA-N 50428286 DABRAFENIB::GSK2118436A Serine/threonine-protein kinase B-raf Homo sapiens 11 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50428286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50428286&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search P06 7RIV,4XV2,5CSW,6HJ2,6V2U,5HIE 44462760 164157161 75045 DB08912 ZINC68153186 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358814 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 150 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358827 CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C InChI=1S/C18H13N3O5/c22-14(23)5-4-10-8-21-13-7-12-9(6-15(24)25)2-1-3-11(12)16(13)20-18(26)17(21)19-10/h1-5,8H,6-7H2,(H,20,26)(H,22,23)(H,24,25)/b5-4+ UIJRICRAFILDOG-SNAWJCMRSA-N 50096279 CHEMBL3577124 Serine/threonine-protein kinase B-raf Homo sapiens 15 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096279&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 4Z5 5C9C 71721540 103993832 CHEMBL3577124 ZINC00022478 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358828 CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C InChI=1S/C22H17N3O2/c1-27-20-12-5-4-11-19(20)25-21(14-13-16-8-6-7-15-23-16)24-18-10-3-2-9-17(18)22(25)26/h2-15H,1H3/b14-13+ WJNBQLVNPARPAK-BUHFOSPRSA-N 50096323 CHEMBL3577123 Serine/threonine-protein kinase B-raf Homo sapiens 4.4 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096323&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89814000 103993876 CHEMBL3577123 ZINC05249767 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358831 CNc1cc2nc(C)c(cc2cn1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C InChI=1S/C26H22ClFN4O/c27-21-8-2-3-9-23(21)32-25(30-22-13-11-18(28)17-20(22)26(32)33)14-12-19-7-6-10-24(29-19)31-15-4-1-5-16-31/h2-3,6-14,17H,1,4-5,15-16H2/b14-12+ UCNQXJWFRZSRRU-WYMLVPIESA-N 50096324 CHEMBL3577121 Serine/threonine-protein kinase B-raf Homo sapiens 28 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096324&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71736864 103993877 CHEMBL3577121 ZINC29479291 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358870 CNc1cc2nc(C)c(cc2cn1)-c1ccc(F)c(NC(=O)NCCC(C)(C)C)c1 InChI=1S/C22H16ClN3O/c1-15-6-2-3-8-20(15)26-21(12-10-17-7-4-5-13-24-17)25-19-14-16(23)9-11-18(19)22(26)27/h2-14H,1H3/b12-10+ IRSLFBOEKZDCQE-ZRDIBKRKSA-N 50096325 CHEMBL3577120 Serine/threonine-protein kinase B-raf Homo sapiens 8.4 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096325&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71736390 103993878 CHEMBL3577120 ZINC29479778 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358871 CNc1ncc2cc(c(C)nc2n1)-c1ccc(F)c(NC(=O)NCCC(C)(C)C)c1 InChI=1S/C22H16ClN3O/c1-15-6-2-3-8-20(15)26-21(12-10-17-7-4-5-13-24-17)25-19-11-9-16(23)14-18(19)22(26)27/h2-14H,1H3/b12-10+ VAIRGGJNURCERD-ZRDIBKRKSA-N 50096328 CHEMBL3577119 Serine/threonine-protein kinase B-raf Homo sapiens 18 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096328&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71730951 103993881 CHEMBL3577119 ZINC29479194 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358872 CNc1cc2nc(C)c(cc2cn1)-c1cc(NC(=O)NCCC(C)(C)C)ccc1C InChI=1S/C22H16ClN3O/c1-15-7-2-3-11-19(15)26-20(13-12-16-8-4-5-14-24-16)25-21-17(22(26)27)9-6-10-18(21)23/h2-14H,1H3/b13-12+ QZLRYCZRJNTIGT-OUKQBFOZSA-N 50096329 CHEMBL3577118 Serine/threonine-protein kinase B-raf Homo sapiens 27 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096329&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71736552 103993882 CHEMBL3577118 ZINC29479671 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358873 CNc1cc2nc(C)c(cc2cn1)-c1cc(NC(=O)NC[C@@H](O)C(C)(C)C)c(F)cc1C InChI=1S/C22H13ClFN3O3/c23-16-5-1-2-7-19(16)27-20(11-9-14-4-3-6-18(25-14)22(29)30)26-17-10-8-13(24)12-15(17)21(27)28/h1-12H,(H,29,30)/b11-9+ PXJPTTIMVOXZBL-PKNBQFBNSA-N 50096330 CHEMBL3577117 Serine/threonine-protein kinase B-raf Homo sapiens 39 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096330&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89827799 103993883 CHEMBL3577117 ZINC29476023 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358874 CCn1c2cc(NC)ncc2cc(-c2cc(NC(=O)NCCC(C)(C)C)c(F)cc2C)c1=O InChI=1S/C21H14ClN3O/c22-17-9-2-4-11-19(17)25-20(13-12-15-7-5-6-14-23-15)24-18-10-3-1-8-16(18)21(25)26/h1-14H/b13-12+ GFIAVWYCWQNCLS-OUKQBFOZSA-N 50096331 CHEMBL3577116 Serine/threonine-protein kinase B-raf Homo sapiens 11 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096331&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122177478 103993884 CHEMBL3577116 ZINC04450431 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358875 CCn1c2cc(NC)ncc2cc(-c2ccc(F)c(NC(=O)Nc3cc(no3)C(C)(C)C)c2)c1=O InChI=1S/C22H15ClFN3O2/c23-18-6-1-2-7-20(18)27-21(11-9-15-4-3-5-16(13-28)25-15)26-19-10-8-14(24)12-17(19)22(27)29/h1-12,28H,13H2/b11-9+ GCRARKBYMYFDTH-PKNBQFBNSA-N 50096332 CHEMBL3577115 Serine/threonine-protein kinase B-raf Homo sapiens 10.0 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096332&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 69037249 103993885 CHEMBL3577115 ZINC29480759 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358876 CNc1cc2n([C@H]3CCOC3)c(=O)c(cc2cn1)-c1ccc(F)c(NC(=O)Nc2cc(no2)C(C)(C)C)c1 InChI=1S/C21H13F2N3O/c22-14-8-10-18-16(13-14)21(27)26(19-7-2-1-6-17(19)23)20(25-18)11-9-15-5-3-4-12-24-15/h1-13H/b11-9+ NKLRLPLSEJDIIC-PKNBQFBNSA-N 50096333 CHEMBL3577114 Serine/threonine-protein kinase B-raf Homo sapiens 18 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096333&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122177477 103993886 CHEMBL3577114 ZINC29481930 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358877 CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29) BFSMGDJOXZAERB-UHFFFAOYSA-N 50428286 DABRAFENIB::GSK2118436A Serine/threonine-protein kinase B-raf Homo sapiens 9.7 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50428286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50428286&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search P06 7RIV,4XV2,5CSW,6HJ2,6V2U,5HIE 44462760 164157161 75045 DB08912 ZINC68153186 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358878 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 34 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358879 CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C InChI=1S/C18H13N3O5/c22-14(23)5-4-10-8-21-13-7-12-9(6-15(24)25)2-1-3-11(12)16(13)20-18(26)17(21)19-10/h1-5,8H,6-7H2,(H,20,26)(H,22,23)(H,24,25)/b5-4+ UIJRICRAFILDOG-SNAWJCMRSA-N 50096279 CHEMBL3577124 Serine/threonine-protein kinase B-raf Homo sapiens 5.8 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096279&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 4Z5 5C9C 71721540 103993832 CHEMBL3577124 ZINC00022478 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358880 CNc1ncc2cc(cnc2n1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C InChI=1S/C22H17N3O2/c1-27-20-12-5-4-11-19(20)25-21(14-13-16-8-6-7-15-23-16)24-18-10-3-2-9-17(18)22(25)26/h2-15H,1H3/b14-13+ WJNBQLVNPARPAK-BUHFOSPRSA-N 50096323 CHEMBL3577123 Serine/threonine-protein kinase B-raf Homo sapiens 2.0 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096323&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89814000 103993876 CHEMBL3577123 ZINC05249767 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358881 Cc1cc(F)c(NC(=O)NCCC(C)(C)C)cc1-c1cc2cnc(N)nc2nc1C InChI=1S/C21H13BrFN3O/c22-17-6-1-2-7-19(17)26-20(11-9-15-5-3-4-12-24-15)25-18-10-8-14(23)13-16(18)21(26)27/h1-13H/b11-9+ AGNIOTWTCBTBJB-PKNBQFBNSA-N 50096334 CHEMBL3577122 Serine/threonine-protein kinase B-raf Homo sapiens 7.9 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096334&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71731206 103993887 CHEMBL3577122 ZINC29481708 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358890 CNc1cc2nc(C)c(cc2cn1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C InChI=1S/C26H22ClFN4O/c27-21-8-2-3-9-23(21)32-25(30-22-13-11-18(28)17-20(22)26(32)33)14-12-19-7-6-10-24(29-19)31-15-4-1-5-16-31/h2-3,6-14,17H,1,4-5,15-16H2/b14-12+ UCNQXJWFRZSRRU-WYMLVPIESA-N 50096324 CHEMBL3577121 Serine/threonine-protein kinase B-raf Homo sapiens 18 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096324&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71736864 103993877 CHEMBL3577121 ZINC29479291 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358893 CNc1cc2nc(C)c(cc2cn1)-c1ccc(F)c(NC(=O)NCCC(C)(C)C)c1 InChI=1S/C22H16ClN3O/c1-15-6-2-3-8-20(15)26-21(12-10-17-7-4-5-13-24-17)25-19-14-16(23)9-11-18(19)22(26)27/h2-14H,1H3/b12-10+ IRSLFBOEKZDCQE-ZRDIBKRKSA-N 50096325 CHEMBL3577120 Serine/threonine-protein kinase B-raf Homo sapiens 3.0 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096325&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71736390 103993878 CHEMBL3577120 ZINC29479778 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358894 CNc1ncc2cc(c(C)nc2n1)-c1ccc(F)c(NC(=O)NCCC(C)(C)C)c1 InChI=1S/C22H16ClN3O/c1-15-6-2-3-8-20(15)26-21(12-10-17-7-4-5-13-24-17)25-19-11-9-16(23)14-18(19)22(26)27/h2-14H,1H3/b12-10+ VAIRGGJNURCERD-ZRDIBKRKSA-N 50096328 CHEMBL3577119 Serine/threonine-protein kinase B-raf Homo sapiens 7.6 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096328&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71730951 103993881 CHEMBL3577119 ZINC29479194 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358895 CNc1cc2nc(C)c(cc2cn1)-c1cc(NC(=O)NCCC(C)(C)C)ccc1C InChI=1S/C22H16ClN3O/c1-15-7-2-3-11-19(15)26-20(13-12-16-8-4-5-14-24-16)25-21-17(22(26)27)9-6-10-18(21)23/h2-14H,1H3/b13-12+ QZLRYCZRJNTIGT-OUKQBFOZSA-N 50096329 CHEMBL3577118 Serine/threonine-protein kinase B-raf Homo sapiens 4.3 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096329&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71736552 103993882 CHEMBL3577118 ZINC29479671 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358896 CNc1cc2nc(C)c(cc2cn1)-c1cc(NC(=O)NC[C@@H](O)C(C)(C)C)c(F)cc1C InChI=1S/C22H13ClFN3O3/c23-16-5-1-2-7-19(16)27-20(11-9-14-4-3-6-18(25-14)22(29)30)26-17-10-8-13(24)12-15(17)21(27)28/h1-12H,(H,29,30)/b11-9+ PXJPTTIMVOXZBL-PKNBQFBNSA-N 50096330 CHEMBL3577117 Serine/threonine-protein kinase B-raf Homo sapiens 7.7 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096330&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 89827799 103993883 CHEMBL3577117 ZINC29476023 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358897 CCn1c2cc(NC)ncc2cc(-c2cc(NC(=O)NCCC(C)(C)C)c(F)cc2C)c1=O InChI=1S/C21H14ClN3O/c22-17-9-2-4-11-19(17)25-20(13-12-15-7-5-6-14-23-15)24-18-10-3-1-8-16(18)21(25)26/h1-14H/b13-12+ GFIAVWYCWQNCLS-OUKQBFOZSA-N 50096331 CHEMBL3577116 Serine/threonine-protein kinase B-raf Homo sapiens 4.2 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096331&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122177478 103993884 CHEMBL3577116 ZINC04450431 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358898 CCn1c2cc(NC)ncc2cc(-c2ccc(F)c(NC(=O)Nc3cc(no3)C(C)(C)C)c2)c1=O InChI=1S/C22H15ClFN3O2/c23-18-6-1-2-7-20(18)27-21(11-9-15-4-3-5-16(13-28)25-15)26-19-10-8-14(24)12-17(19)22(27)29/h1-12,28H,13H2/b11-9+ GCRARKBYMYFDTH-PKNBQFBNSA-N 50096332 CHEMBL3577115 Serine/threonine-protein kinase B-raf Homo sapiens 1.2 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096332&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 69037249 103993885 CHEMBL3577115 ZINC29480759 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358899 CNc1cc2n([C@H]3CCOC3)c(=O)c(cc2cn1)-c1ccc(F)c(NC(=O)Nc2cc(no2)C(C)(C)C)c1 InChI=1S/C21H13F2N3O/c22-14-8-10-18-16(13-14)21(27)26(19-7-2-1-6-17(19)23)20(25-18)11-9-15-5-3-4-12-24-15/h1-13H/b11-9+ NKLRLPLSEJDIIC-PKNBQFBNSA-N 50096333 CHEMBL3577114 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096333&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122177477 103993886 CHEMBL3577114 ZINC29481930 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50358900 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 6.1 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50359011 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 260 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50359012 CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29) BFSMGDJOXZAERB-UHFFFAOYSA-N 50428286 DABRAFENIB::GSK2118436A Serine/threonine-protein kinase B-raf Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50428286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50428286&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search P06 7RIV,4XV2,5CSW,6HJ2,6V2U,5HIE 44462760 164157161 75045 DB08912 ZINC68153186 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50359013 CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C InChI=1S/C18H13N3O5/c22-14(23)5-4-10-8-21-13-7-12-9(6-15(24)25)2-1-3-11(12)16(13)20-18(26)17(21)19-10/h1-5,8H,6-7H2,(H,20,26)(H,22,23)(H,24,25)/b5-4+ UIJRICRAFILDOG-SNAWJCMRSA-N 50096279 CHEMBL3577124 Serine/threonine-protein kinase B-raf Homo sapiens 31 ChEMBL 10.1021/acs.jmedchem.5b00067 10.7270/Q2ZS2Z85 25965804 Henry, JR; Kaufman, MD; Peng, SB; Ahn, YM; Caldwell, TM; Vogeti, L; Telikepalli, H; Lu, WP; Hood, MM; Rutkoski, TJ; Smith, BD; Vogeti, S; Miller, D; Wise, SC; Chun, L; Zhang, X; Zhang, Y; Kays, L; Hipskind, PA; Wrobleski, AD; Lobb, KL; Clay, JM; Cohen, JD; Walgren, JL; McCann, D; Patel, P; Clawson, DK; Guo, S; Manglicmot, D; Groshong, C; Logan, C; Starling, JJ; Flynn, DL Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50096279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50096279&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 4Z5 5C9C 71721540 103993832 CHEMBL3577124 ZINC00022478 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50370641 COc1cccc(c1)C(=O)Nc1ccc(C)c(c1)C(=O)Nc1ccc(nc1)-c1ncc[nH]1 InChI=1S/C24H21N5O3/c1-15-6-7-17(28-23(30)16-4-3-5-19(12-16)32-2)13-20(15)24(31)29-18-8-9-21(27-14-18)22-25-10-11-26-22/h3-14H,1-2H3,(H,25,26)(H,28,30)(H,29,31) JTXHRRLLHCWTMB-UHFFFAOYSA-N 50059793 CHEMBL3393796 Serine/threonine-protein kinase B-raf Homo sapiens 2470 ChEMBL 10.1016/j.ejmech.2014.11.008 10.7270/Q2S18451 25461318 Jiao, Y; Xin, BT; Zhang, Y; Wu, J; Lu, X; Zheng, Y; Tang, W; Zhou, X China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059793&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118725683 103955574 CHEMBL3393796 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50370643 FC(F)(F)c1cc(NC(=O)c2ccc(Cl)c(c2)C(=O)Nc2ccc(nc2)-c2ncc[nH]2)ccc1Cl InChI=1S/C23H14Cl2F3N5O2/c24-17-4-1-12(21(34)32-13-2-5-18(25)16(10-13)23(26,27)28)9-15(17)22(35)33-14-3-6-19(31-11-14)20-29-7-8-30-20/h1-11H,(H,29,30)(H,32,34)(H,33,35) WLMAHUGJWNORQI-UHFFFAOYSA-N 50059791 CHEMBL3393897 Serine/threonine-protein kinase B-raf Homo sapiens 531 ChEMBL 10.1016/j.ejmech.2014.11.008 10.7270/Q2S18451 25461318 Jiao, Y; Xin, BT; Zhang, Y; Wu, J; Lu, X; Zheng, Y; Tang, W; Zhou, X China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059791&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118725758 103955572 CHEMBL3393897 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50374889 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase B-raf Homo sapiens 5.0 ChEMBL 10.1016/j.bmc.2014.12.026 10.7270/Q23X88F1 25662701 Ye, Q; Mao, W; Zhou, Y; Xu, L; Li, Q; Gao, Y; Wang, J; Li, C; Xu, Y; Xu, Y; Liao, H; Zhang, L; Gao, J; Li, J; Pang, T Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390546 Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C20H16F2N4O3/c21-20(22)28-16-6-5-13(10-17(16)29-20)26-19(27)14-3-1-2-4-15(14)25-11-12-7-8-24-18(23)9-12/h1-10,25H,11H2,(H2,23,24)(H,26,27) COXZTUCUTWYLEP-UHFFFAOYSA-N 50215758 2-((2-aminopyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide::CHEMBL400109 Serine/threonine-protein kinase B-raf Homo sapiens 634 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215758&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442395 104090313 CHEMBL400109 ZINC28951767 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390547 OCCOCCNc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C24H24F2N4O5/c25-24(26)34-20-6-5-17(14-21(20)35-24)30-23(32)18-3-1-2-4-19(18)29-15-16-7-8-27-22(13-16)28-9-11-33-12-10-31/h1-8,13-14,29,31H,9-12,15H2,(H,27,28)(H,30,32) IDFVXZZDQOMMGE-UHFFFAOYSA-N 50215759 CHEMBL247423::N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(2-(2-hydroxyethoxy)ethylamino)pyridin-4-yl)methylamino)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 165 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215759&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442407 104090314 CHEMBL247423 ZINC28951809 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390548 FC1(F)Oc2ccc(NC(=O)c3ccccc3NCc3ccnc(NC(=O)NCc4ccccc4)c3)cc2O1 InChI=1S/C28H23F2N5O4/c29-28(30)38-23-11-10-20(15-24(23)39-28)34-26(36)21-8-4-5-9-22(21)32-17-19-12-13-31-25(14-19)35-27(37)33-16-18-6-2-1-3-7-18/h1-15,32H,16-17H2,(H,34,36)(H2,31,33,35,37) QRLOFSLOYOQNON-UHFFFAOYSA-N 50215760 1-(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)pyridin-2-yl)-3-benzylurea::CHEMBL395705 Serine/threonine-protein kinase B-raf Homo sapiens 232 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215760&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442412 104090315 CHEMBL395705 ZINC28951831 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390549 CNC(=O)Nc1ccc(CNc2ncsc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)cn1 InChI=1S/C19H16F2N6O4S/c1-22-18(29)27-14-5-2-10(7-23-14)8-24-16-15(32-9-25-16)17(28)26-11-3-4-12-13(6-11)31-19(20,21)30-12/h2-7,9,24H,8H2,1H3,(H,26,28)(H2,22,23,27,29) APMQKHHNTLVDQD-UHFFFAOYSA-N 50215761 1-(5-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)thiazol-4-ylamino)methyl)pyridin-2-yl)-3-methylurea::CHEMBL247250 Serine/threonine-protein kinase B-raf Homo sapiens 69 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215761&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442418 104090316 CHEMBL247250 ZINC28951859 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390551 CNC(=O)Nc1ccc(CNc2c(cnn2C)C(=O)Nc2ccc(SC(F)(F)F)cc2)cn1 InChI=1S/C20H20F3N7O2S/c1-24-19(32)29-16-8-3-12(9-25-16)10-26-17-15(11-27-30(17)2)18(31)28-13-4-6-14(7-5-13)33-20(21,22)23/h3-9,11,26H,10H2,1-2H3,(H,28,31)(H2,24,25,29,32) MHVFDATVTOZXQW-UHFFFAOYSA-N 50215763 1-methyl-3-(5-((1-methyl-4-((4-(trifluoromethylthio)phenyl)carbamoyl)-1H-pyrazol-5-ylamino)methyl)pyridin-2-yl)urea::CHEMBL247797 Serine/threonine-protein kinase B-raf Homo sapiens 899 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215763&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442416 104090318 CHEMBL247797 ZINC28951850 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390552 FC1(F)Oc2ccc(NC(=O)c3ccccc3NCc3ccnc(c3)C3=NCCN3)cc2O1 InChI=1S/C23H19F2N5O3/c24-23(25)32-19-6-5-15(12-20(19)33-23)30-22(31)16-3-1-2-4-17(16)29-13-14-7-8-26-18(11-14)21-27-9-10-28-21/h1-8,11-12,29H,9-10,13H2,(H,27,28)(H,30,31) QDDQDPRUOSGUNC-UHFFFAOYSA-N 50215764 CHEMBL400308::N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(4,5-dihydro-1H-imidazol-2-yl)pyridin-4-yl)methylamino)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 153 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215764&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442399 104090319 CHEMBL400308 ZINC28951775 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390556 NC(=O)c1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C21H16F2N4O4/c22-21(23)30-17-6-5-13(10-18(17)31-21)27-20(29)14-3-1-2-4-15(14)26-11-12-7-8-25-16(9-12)19(24)28/h1-10,26H,11H2,(H2,24,28)(H,27,29) DCTIKIWYRXDSOC-UHFFFAOYSA-N 50215766 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)picolinamide::CHEMBL248051 Serine/threonine-protein kinase B-raf Homo sapiens 34 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215766&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442388 104090321 CHEMBL248051 ZINC28951746 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390560 FC1(F)Oc2ccc(NC(=O)c3ncsc3NCc3ccncc3)cc2OC1(F)F InChI=1S/C18H12F4N4O3S/c19-17(20)18(21,22)29-13-7-11(1-2-12(13)28-17)26-15(27)14-16(30-9-25-14)24-8-10-3-5-23-6-4-10/h1-7,9,24H,8H2,(H,26,27) PIMSTQWPHQNTGW-UHFFFAOYSA-N 50215769 5-(pyridin-4-ylmethylamino)-N-(2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)thiazole-4-carboxamide::CHEMBL392600 Serine/threonine-protein kinase B-raf Homo sapiens 2560 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215769&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442414 104090324 CHEMBL392600 ZINC28951839 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390561 FC1(F)Oc2ccc(NC(=O)c3ccccc3NCc3ccnc(c3)C(=O)NC3CC3)cc2O1 InChI=1S/C24H20F2N4O4/c25-24(26)33-20-8-7-16(12-21(20)34-24)30-22(31)17-3-1-2-4-18(17)28-13-14-9-10-27-19(11-14)23(32)29-15-5-6-15/h1-4,7-12,15,28H,5-6,13H2,(H,29,32)(H,30,31) NCJGUXSHLPYQDR-UHFFFAOYSA-N 50215771 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-cyclopropylpicolinamide::CHEMBL248398 Serine/threonine-protein kinase B-raf Homo sapiens 192 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215771&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11634109 104090326 CHEMBL248398 ZINC28951756 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390564 CCNC(=O)Nc1ccc(CNc2ncsc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)cn1 InChI=1S/C20H18F2N6O4S/c1-2-23-19(30)28-15-6-3-11(8-24-15)9-25-17-16(33-10-26-17)18(29)27-12-4-5-13-14(7-12)32-20(21,22)31-13/h3-8,10,25H,2,9H2,1H3,(H,27,29)(H2,23,24,28,30) BPGIPYJOESFNQI-UHFFFAOYSA-N 50215770 1-(5-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)thiazol-4-ylamino)methyl)pyridin-2-yl)-3-ethylurea::CHEMBL247798 Serine/threonine-protein kinase B-raf Homo sapiens 122 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215770&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442417 104090325 CHEMBL247798 ZINC28951852 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390567 Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C20H16F2N4O3/c21-20(22)28-16-6-5-13(10-17(16)29-20)26-19(27)14-3-1-2-4-15(14)25-11-12-7-8-24-18(23)9-12/h1-10,25H,11H2,(H2,23,24)(H,26,27) COXZTUCUTWYLEP-UHFFFAOYSA-N 50215758 2-((2-aminopyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide::CHEMBL400109 Serine/threonine-protein kinase B-raf Homo sapiens 634 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215758&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442395 104090313 CHEMBL400109 ZINC28951767 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390568 CNc1nccc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)n1 InChI=1S/C20H17F2N5O3/c1-23-19-24-9-8-13(27-19)11-25-15-5-3-2-4-14(15)18(28)26-12-6-7-16-17(10-12)30-20(21,22)29-16/h2-10,25H,11H2,1H3,(H,26,28)(H,23,24,27) LRUKBEHTGXFIJS-UHFFFAOYSA-N 50215774 CHEMBL246424::N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(methylamino)pyrimidin-4-yl)methylamino)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 26 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215774&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11697289 104090329 CHEMBL246424 ZINC28951779 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390569 CNC(=O)Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C22H19F2N5O4/c1-25-21(31)29-19-10-13(8-9-26-19)12-27-16-5-3-2-4-15(16)20(30)28-14-6-7-17-18(11-14)33-22(23,24)32-17/h2-11,27H,12H2,1H3,(H,28,30)(H2,25,26,29,31) VBXKSTHBDBMAQV-UHFFFAOYSA-N 50215775 1-(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)pyridin-2-yl)-3-methylurea::CHEMBL394503 Serine/threonine-protein kinase B-raf Homo sapiens 24 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215775&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11583341 104090330 CHEMBL394503 ZINC28951816 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390570 CNC(=O)c1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C22H18F2N4O4/c1-25-21(30)17-10-13(8-9-26-17)12-27-16-5-3-2-4-15(16)20(29)28-14-6-7-18-19(11-14)32-22(23,24)31-18/h2-11,27H,12H2,1H3,(H,25,30)(H,28,29) OYNIXDXAPYDRHC-UHFFFAOYSA-N 50215773 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-methylpicolinamide::CHEMBL247437 Serine/threonine-protein kinase B-raf Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215773&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11704845 104090328 CHEMBL247437 ZINC28951869 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390571 CNC(=O)Nc1ccc(CNc2c(cnn2C)C(=O)Nc2ccc3OC(F)(F)C(F)(F)Oc3c2)cn1 InChI=1S/C21H19F4N7O4/c1-26-19(34)31-16-6-3-11(8-27-16)9-28-17-13(10-29-32(17)2)18(33)30-12-4-5-14-15(7-12)36-21(24,25)20(22,23)35-14/h3-8,10,28H,9H2,1-2H3,(H,30,33)(H2,26,27,31,34) MEQSMKIFBMBPQX-UHFFFAOYSA-N 50215768 1-methyl-3-(5-((1-methyl-4-((2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)carbamoyl)-1H-pyrazol-5-ylamino)methyl)pyridin-2-yl)urea::CHEMBL247619 Serine/threonine-protein kinase B-raf Homo sapiens 191 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215768&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442415 104090323 CHEMBL247619 ZINC28951848 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390572 CCNC(=O)Nc1ccc(CNc2ncsc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)cn1 InChI=1S/C20H18F2N6O4S/c1-2-23-19(30)28-15-6-3-11(8-24-15)9-25-17-16(33-10-26-17)18(29)27-12-4-5-13-14(7-12)32-20(21,22)31-13/h3-8,10,25H,2,9H2,1H3,(H,27,29)(H2,23,24,28,30) BPGIPYJOESFNQI-UHFFFAOYSA-N 50215770 1-(5-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)thiazol-4-ylamino)methyl)pyridin-2-yl)-3-ethylurea::CHEMBL247798 Serine/threonine-protein kinase B-raf Homo sapiens 824 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215770&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442417 104090325 CHEMBL247798 ZINC28951852 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390573 OCCNc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C22H20F2N4O4/c23-22(24)31-18-6-5-15(12-19(18)32-22)28-21(30)16-3-1-2-4-17(16)27-13-14-7-8-25-20(11-14)26-9-10-29/h1-8,11-12,27,29H,9-10,13H2,(H,25,26)(H,28,30) MBUPGYAZYBFASN-UHFFFAOYSA-N 50215782 CHEMBL398052::N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(2-hydroxyethylamino)pyridin-4-yl)methylamino)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 112 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215782&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442404 104090337 CHEMBL398052 ZINC28951797 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390574 FC1(F)Oc2ccc(NC(=O)c3ccccc3NCc3ccncc3)cc2OC1(F)F InChI=1S/C21H15F4N3O3/c22-20(23)21(24,25)31-18-11-14(5-6-17(18)30-20)28-19(29)15-3-1-2-4-16(15)27-12-13-7-9-26-10-8-13/h1-11,27H,12H2,(H,28,29) DKDIYRYSJHNWTO-UHFFFAOYSA-N 50215781 2-(pyridin-4-ylmethylamino)-N-(2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzamide::CHEMBL391781 Serine/threonine-protein kinase B-raf Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215781&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442419 104090336 CHEMBL391781 ZINC28951867 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390577 CNC(=O)Nc1ccc(CNc2ncsc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)cn1 InChI=1S/C19H16F2N6O4S/c1-22-18(29)27-14-5-2-10(7-23-14)8-24-16-15(32-9-25-16)17(28)26-11-3-4-12-13(6-11)31-19(20,21)30-12/h2-7,9,24H,8H2,1H3,(H,26,28)(H2,22,23,27,29) APMQKHHNTLVDQD-UHFFFAOYSA-N 50215761 1-(5-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)thiazol-4-ylamino)methyl)pyridin-2-yl)-3-methylurea::CHEMBL247250 Serine/threonine-protein kinase B-raf Homo sapiens 508 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215761&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442418 104090316 CHEMBL247250 ZINC28951859 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390578 COCCNC(=O)c1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C24H22F2N4O5/c1-33-11-10-28-23(32)19-12-15(8-9-27-19)14-29-18-5-3-2-4-17(18)22(31)30-16-6-7-20-21(13-16)35-24(25,26)34-20/h2-9,12-13,29H,10-11,14H2,1H3,(H,28,32)(H,30,31) WZERXMDVFBGCAP-UHFFFAOYSA-N 50215780 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(2-methoxyethyl)picolinamide::CHEMBL245805 Serine/threonine-protein kinase B-raf Homo sapiens 497 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215780&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11605467 104090335 CHEMBL245805 ZINC28951760 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390580 FC1(F)Oc2ccc(NC(=O)c3ccccc3NCc3ccnc(NC(=O)Nc4ccc5CCCc5c4)c3)cc2O1 InChI=1S/C30H25F2N5O4/c31-30(32)40-25-11-10-22(16-26(25)41-30)35-28(38)23-6-1-2-7-24(23)34-17-18-12-13-33-27(14-18)37-29(39)36-21-9-8-19-4-3-5-20(19)15-21/h1-2,6-16,34H,3-5,17H2,(H,35,38)(H2,33,36,37,39) IJYMFACDQZQZLG-UHFFFAOYSA-N 50215783 1-(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)pyridin-2-yl)-3-(2,3-dihydro-1H-inden-5-yl)urea::CHEMBL399571 Serine/threonine-protein kinase B-raf Homo sapiens 64 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215783&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442411 104090338 CHEMBL399571 ZINC28951826 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390581 COCCCNc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C24H24F2N4O4/c1-32-12-4-10-27-22-13-16(9-11-28-22)15-29-19-6-3-2-5-18(19)23(31)30-17-7-8-20-21(14-17)34-24(25,26)33-20/h2-3,5-9,11,13-14,29H,4,10,12,15H2,1H3,(H,27,28)(H,30,31) ZUURGOPVVCUCTB-UHFFFAOYSA-N 50215776 CHEMBL247591::N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(3-methoxypropylamino)pyridin-4-yl)methylamino)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 156 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215776&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442405 104090331 CHEMBL247591 ZINC28951801 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390582 CCN(CC)CCCNC(=O)c1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C28H31F2N5O4/c1-3-35(4-2)15-7-13-32-27(37)23-16-19(12-14-31-23)18-33-22-9-6-5-8-21(22)26(36)34-20-10-11-24-25(17-20)39-28(29,30)38-24/h5-6,8-12,14,16-17,33H,3-4,7,13,15,18H2,1-2H3,(H,32,37)(H,34,36) RMIFSWAMEGYQEO-UHFFFAOYSA-N 50215779 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(3-(diethylamino)propyl)picolinamide::CHEMBL248397 Serine/threonine-protein kinase B-raf Homo sapiens 175 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215779&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442390 104090334 CHEMBL248397 ZINC28951752 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390583 CNC(=O)c1cc(CNc2c(cnn2C)C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C20H18F2N6O4/c1-23-19(30)14-7-11(5-6-24-14)9-25-17-13(10-26-28(17)2)18(29)27-12-3-4-15-16(8-12)32-20(21,22)31-15/h3-8,10,25H,9H2,1-2H3,(H,23,30)(H,27,29) FJYFVYKYNSQZCC-UHFFFAOYSA-N 50215777 4-((4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)-1-methyl-1H-pyrazol-5-ylamino)methyl)-N-methylpicolinamide::CHEMBL247435 Serine/threonine-protein kinase B-raf Homo sapiens 199 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215777&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16101466 104090332 CHEMBL247435 ZINC28951841 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390584 FC1(F)Oc2ccc(NC(=O)c3ccccc3NCc3ccnc(NC(=O)Nc4ccccc4)c3)cc2O1 InChI=1S/C27H21F2N5O4/c28-27(29)37-22-11-10-19(15-23(22)38-27)32-25(35)20-8-4-5-9-21(20)31-16-17-12-13-30-24(14-17)34-26(36)33-18-6-2-1-3-7-18/h1-15,31H,16H2,(H,32,35)(H2,30,33,34,36) BOPCXEIMMJMHTF-UHFFFAOYSA-N 50215778 1-(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)pyridin-2-yl)-3-phenylurea::CHEMBL397345 Serine/threonine-protein kinase B-raf Homo sapiens 39 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215778&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442410 104090333 CHEMBL397345 ZINC28951822 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390588 CCNC(=O)Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C23H21F2N5O4/c1-2-26-22(32)30-20-11-14(9-10-27-20)13-28-17-6-4-3-5-16(17)21(31)29-15-7-8-18-19(12-15)34-23(24,25)33-18/h3-12,28H,2,13H2,1H3,(H,29,31)(H2,26,27,30,32) ACBAZTUYTSKGTP-UHFFFAOYSA-N 50215789 1-(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)pyridin-2-yl)-3-ethylurea::CHEMBL247793 Serine/threonine-protein kinase B-raf Homo sapiens 90 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215789&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11705461 104090344 CHEMBL247793 ZINC28951820 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390592 CCN(CC)CCNC(=O)c1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C27H29F2N5O4/c1-3-34(4-2)14-13-31-26(36)22-15-18(11-12-30-22)17-32-21-8-6-5-7-20(21)25(35)33-19-9-10-23-24(16-19)38-27(28,29)37-23/h5-12,15-16,32H,3-4,13-14,17H2,1-2H3,(H,31,36)(H,33,35) HAQQTZNLPUNEGW-UHFFFAOYSA-N 50215786 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(2-(diethylamino)ethyl)picolinamide::CHEMBL248227 Serine/threonine-protein kinase B-raf Homo sapiens 138 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215786&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442389 104090341 CHEMBL248227 ZINC28951750 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390598 CNC(=O)c1cc(CNc2ncsc2C(=O)Nc2ccc3OC(F)(F)C(F)(F)Oc3c2)ccn1 InChI=1S/C20H15F4N5O4S/c1-25-17(30)12-6-10(4-5-26-12)8-27-16-15(34-9-28-16)18(31)29-11-2-3-13-14(7-11)33-20(23,24)19(21,22)32-13/h2-7,9,27H,8H2,1H3,(H,25,30)(H,29,31) BAFNQSRMVYVKQR-UHFFFAOYSA-N 50215787 4-((5-((2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)carbamoyl)thiazol-4-ylamino)methyl)-N-methylpicolinamide::CHEMBL247434 Serine/threonine-protein kinase B-raf Homo sapiens 192 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215787&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442413 104090342 CHEMBL247434 ZINC28951837 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390599 FC1(F)Oc2ccc(NC(=O)c3ccccc3NCc3ccnc(c3)C(=O)NCCCN3CCOCC3)cc2O1 InChI=1S/C28H29F2N5O5/c29-28(30)39-24-7-6-20(17-25(24)40-28)34-26(36)21-4-1-2-5-22(21)33-18-19-8-10-31-23(16-19)27(37)32-9-3-11-35-12-14-38-15-13-35/h1-2,4-8,10,16-17,33H,3,9,11-15,18H2,(H,32,37)(H,34,36) PYSNXODTSWLJKM-UHFFFAOYSA-N 50215762 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(3-morpholinopropyl)picolinamide::CHEMBL398872 Serine/threonine-protein kinase B-raf Homo sapiens 6830 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215762&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442391 104090317 CHEMBL398872 ZINC28951754 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390602 FC1(F)Oc2ccc(NC(=O)c3ccccc3NCc3ccnc(NCCCn4ccnc4)c3)cc2O1 InChI=1S/C26H24F2N6O3/c27-26(28)36-22-7-6-19(15-23(22)37-26)33-25(35)20-4-1-2-5-21(20)32-16-18-8-10-31-24(14-18)30-9-3-12-34-13-11-29-17-34/h1-2,4-8,10-11,13-15,17,32H,3,9,12,16H2,(H,30,31)(H,33,35) NRCYJQOXMJLQTP-UHFFFAOYSA-N 50215790 2-((2-(3-(1H-imidazol-1-yl)propylamino)pyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide::CHEMBL247424 Serine/threonine-protein kinase B-raf Homo sapiens 101 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215790&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442408 104090345 CHEMBL247424 ZINC28951811 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390605 CS(=O)(=O)Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C21H18F2N4O5S/c1-33(29,30)27-19-10-13(8-9-24-19)12-25-16-5-3-2-4-15(16)20(28)26-14-6-7-17-18(11-14)32-21(22,23)31-17/h2-11,25H,12H2,1H3,(H,24,27)(H,26,28) YZNNUIOSLHHWJF-UHFFFAOYSA-N 50215794 CHEMBL246423::N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(methylsulfonamido)pyridin-4-yl)methylamino)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 594 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215794&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442400 104090349 CHEMBL246423 ZINC28951777 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390613 CNC(=O)c1cc(CNc2ccsc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C20H16F2N4O4S/c1-23-18(27)14-8-11(4-6-24-14)10-25-13-5-7-31-17(13)19(28)26-12-2-3-15-16(9-12)30-20(21,22)29-15/h2-9,25H,10H2,1H3,(H,23,27)(H,26,28) CXDOYTGMCAHUID-UHFFFAOYSA-N 50215793 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)thiophen-3-ylamino)methyl)-N-methylpicolinamide::CHEMBL247618 Serine/threonine-protein kinase B-raf Homo sapiens 61 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215793&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11597486 104090348 CHEMBL247618 ZINC28951846 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390616 CN(C)c1nccc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)n1 InChI=1S/C21H19F2N5O3/c1-28(2)20-24-10-9-14(27-20)12-25-16-6-4-3-5-15(16)19(29)26-13-7-8-17-18(11-13)31-21(22,23)30-17/h3-11,25H,12H2,1-2H3,(H,26,29) ROESLTYJYYWMJD-UHFFFAOYSA-N 50215796 CHEMBL400057::N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(dimethylamino)pyrimidin-4-yl)methylamino)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 349 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215796&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442401 104090351 CHEMBL400057 ZINC28951781 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390618 OCCCNc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C23H22F2N4O4/c24-23(25)32-19-7-6-16(13-20(19)33-23)29-22(31)17-4-1-2-5-18(17)28-14-15-8-10-27-21(12-15)26-9-3-11-30/h1-2,4-8,10,12-13,28,30H,3,9,11,14H2,(H,26,27)(H,29,31) IHZBPVIBWDITMK-UHFFFAOYSA-N 50215798 CHEMBL395700::N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(3-hydroxypropylamino)pyridin-4-yl)methylamino)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 142 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215798&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442406 104090353 CHEMBL395700 ZINC28951803 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390620 FC1(F)Oc2ccc(NC(=O)c3ccccc3NCc3ccnc(c3)C#N)cc2O1 InChI=1S/C21H14F2N4O3/c22-21(23)29-18-6-5-14(10-19(18)30-21)27-20(28)16-3-1-2-4-17(16)26-12-13-7-8-25-15(9-13)11-24/h1-10,26H,12H2,(H,27,28) MBVMUJLUEAVVFH-UHFFFAOYSA-N 50215797 2-((2-cyanopyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide::CHEMBL248257 Serine/threonine-protein kinase B-raf Homo sapiens 110 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215797&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442397 104090352 CHEMBL248257 ZINC28951771 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390623 CCNC(=O)c1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C23H20F2N4O4/c1-2-26-22(31)18-11-14(9-10-27-18)13-28-17-6-4-3-5-16(17)21(30)29-15-7-8-19-20(12-15)33-23(24,25)32-19/h3-12,28H,2,13H2,1H3,(H,26,31)(H,29,30) LQXIQYJEMNHPCH-UHFFFAOYSA-N 50215765 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-ethylpicolinamide::CHEMBL248226 Serine/threonine-protein kinase B-raf Homo sapiens 333 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215765&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11604883 104090320 CHEMBL248226 ZINC28951748 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390624 CNC(=O)c1cc(CNc2ncsc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C19H15F2N5O4S/c1-22-17(27)12-6-10(4-5-23-12)8-24-16-15(31-9-25-16)18(28)26-11-2-3-13-14(7-11)30-19(20,21)29-13/h2-7,9,24H,8H2,1H3,(H,22,27)(H,26,28) GXFMUXGPPXGMTM-UHFFFAOYSA-N 50215792 4-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)thiazol-4-ylamino)methyl)-N-methylpicolinamide::CHEMBL247248 Serine/threonine-protein kinase B-raf Homo sapiens 1240 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215792&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11561411 104090347 CHEMBL247248 ZINC28951833 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390629 CNC(=O)Nc1ccc(CNc2c(cnn2C)C(=O)Nc2ccc(SC(F)(F)F)cc2)cn1 InChI=1S/C20H20F3N7O2S/c1-24-19(32)29-16-8-3-12(9-25-16)10-26-17-15(11-27-30(17)2)18(31)28-13-4-6-14(7-5-13)33-20(21,22)23/h3-9,11,26H,10H2,1-2H3,(H,28,31)(H2,24,25,29,32) MHVFDATVTOZXQW-UHFFFAOYSA-N 50215763 1-methyl-3-(5-((1-methyl-4-((4-(trifluoromethylthio)phenyl)carbamoyl)-1H-pyrazol-5-ylamino)methyl)pyridin-2-yl)urea::CHEMBL247797 Serine/threonine-protein kinase B-raf Homo sapiens 154 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215763&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442416 104090318 CHEMBL247797 ZINC28951850 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390630 CS(=O)(=O)CCNC(=O)c1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C24H22F2N4O6S/c1-37(33,34)11-10-28-23(32)19-12-15(8-9-27-19)14-29-18-5-3-2-4-17(18)22(31)30-16-6-7-20-21(13-16)36-24(25,26)35-20/h2-9,12-13,29H,10-11,14H2,1H3,(H,28,32)(H,30,31) NXEKPYWQVKXSPV-UHFFFAOYSA-N 50215795 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(2-(methylsulfonyl)ethyl)picolinamide::CHEMBL245804 Serine/threonine-protein kinase B-raf Homo sapiens 221 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215795&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442392 104090350 CHEMBL245804 ZINC28951758 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390632 FC1(F)Oc2ccc(NC(=O)c3ccccc3NCc3ccnc(NCCc4cnc[nH]4)c3)cc2O1 InChI=1S/C25H22F2N6O3/c26-25(27)35-21-6-5-17(12-22(21)36-25)33-24(34)19-3-1-2-4-20(19)31-13-16-7-9-29-23(11-16)30-10-8-18-14-28-15-32-18/h1-7,9,11-12,14-15,31H,8,10,13H2,(H,28,32)(H,29,30)(H,33,34) FLYZOVOQWUDRBN-UHFFFAOYSA-N 50215799 2-((2-(2-(1H-imidazol-5-yl)ethylamino)pyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide::CHEMBL247792 Serine/threonine-protein kinase B-raf Homo sapiens 146 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215799&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442409 104090354 CHEMBL247792 ZINC28951815 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390637 CNc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C21H18F2N4O3/c1-24-19-10-13(8-9-25-19)12-26-16-5-3-2-4-15(16)20(28)27-14-6-7-17-18(11-14)30-21(22,23)29-17/h2-11,26H,12H2,1H3,(H,24,25)(H,27,28) QXMRDWNIKLPTAU-UHFFFAOYSA-N 50215788 CHEMBL399534::N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(methylamino)pyridin-4-yl)methylamino)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215788&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442402 104090343 CHEMBL399534 ZINC28951792 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390638 CNC(=O)Nc1ccc(CNc2c(cnn2C)C(=O)Nc2ccc3OC(F)(F)C(F)(F)Oc3c2)cn1 InChI=1S/C21H19F4N7O4/c1-26-19(34)31-16-6-3-11(8-27-16)9-28-17-13(10-29-32(17)2)18(33)30-12-4-5-14-15(7-12)36-21(24,25)20(22,23)35-14/h3-8,10,28H,9H2,1-2H3,(H,30,33)(H2,26,27,31,34) MEQSMKIFBMBPQX-UHFFFAOYSA-N 50215768 1-methyl-3-(5-((1-methyl-4-((2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)carbamoyl)-1H-pyrazol-5-ylamino)methyl)pyridin-2-yl)urea::CHEMBL247619 Serine/threonine-protein kinase B-raf Homo sapiens 448 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215768&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442415 104090323 CHEMBL247619 ZINC28951848 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390639 CC(=O)Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C22H18F2N4O4/c1-13(29)27-20-10-14(8-9-25-20)12-26-17-5-3-2-4-16(17)21(30)28-15-6-7-18-19(11-15)32-22(23,24)31-18/h2-11,26H,12H2,1H3,(H,28,30)(H,25,27,29) JDQIOIVXAWOMGD-UHFFFAOYSA-N 50215791 2-((2-acetamidopyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide::CHEMBL248256 Serine/threonine-protein kinase B-raf Homo sapiens 5 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215791&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442396 104090346 CHEMBL248256 ZINC28951769 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390585 COCCCNC(=O)c1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C25H24F2N4O5/c1-34-12-4-10-29-24(33)20-13-16(9-11-28-20)15-30-19-6-3-2-5-18(19)23(32)31-17-7-8-21-22(14-17)36-25(26,27)35-21/h2-3,5-9,11,13-14,30H,4,10,12,15H2,1H3,(H,29,33)(H,31,32) BLXZMOITRCHHRV-UHFFFAOYSA-N 50215785 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(3-methoxypropyl)picolinamide::CHEMBL247030 Serine/threonine-protein kinase B-raf Homo sapiens 1030 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215785&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442393 104090340 CHEMBL247030 ZINC28951762 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390586 COCCNc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C23H22F2N4O4/c1-31-11-10-27-21-12-15(8-9-26-21)14-28-18-5-3-2-4-17(18)22(30)29-16-6-7-19-20(13-16)33-23(24,25)32-19/h2-9,12-13,28H,10-11,14H2,1H3,(H,26,27)(H,29,30) KOTIZNKRVDGKNU-UHFFFAOYSA-N 50215772 CHEMBL248860::N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(2-methoxyethylamino)pyridin-4-yl)methylamino)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 104 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215772&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442403 104090327 CHEMBL248860 ZINC28951794 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390587 OCCNC(=O)c1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C23H20F2N4O5/c24-23(25)33-19-6-5-15(12-20(19)34-23)29-21(31)16-3-1-2-4-17(16)28-13-14-7-8-26-18(11-14)22(32)27-9-10-30/h1-8,11-12,28,30H,9-10,13H2,(H,27,32)(H,29,31) XTMWIEVQVYQIFB-UHFFFAOYSA-N 50215784 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(2-hydroxyethyl)picolinamide::CHEMBL246608 Serine/threonine-protein kinase B-raf Homo sapiens 397 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215784&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442394 104090339 CHEMBL246608 C04080 ZINC28951764 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50390641 NC(=S)c1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 InChI=1S/C21H16F2N4O3S/c22-21(23)29-17-6-5-13(10-18(17)30-21)27-20(28)14-3-1-2-4-15(14)26-11-12-7-8-25-16(9-12)19(24)31/h1-10,26H,11H2,(H2,24,31)(H,27,28) DIOLCKJIPOAFOB-UHFFFAOYSA-N 50215767 2-((2-carbamothioylpyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide::CHEMBL248258 Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1016/j.bmcl.2007.02.075 10.7270/Q28K78S7 17574417 Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J Bayer Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50215767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50215767&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44442398 104090322 CHEMBL248258 ZINC28951773 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408677 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c4ccccc4c23)c1 InChI=1S/C17H15N5O2S/c1-18-25(23,24)12-6-4-5-11(9-12)21-16-15-13-7-2-3-8-14(13)22-17(15)20-10-19-16/h2-10,18H,1H3,(H2,19,20,21,22) RQNWKCHEEKHWBJ-UHFFFAOYSA-N 50118390 CHEMBL3613191 Serine/threonine-protein kinase B-raf Homo sapiens 40 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118390&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52933587 104011708 CHEMBL3613191 ZINC13491216 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408718 CNS(=O)(=O)c1ccc(N2CCOCC2)c(Nc2ncnc3[nH]c(cc23)-c2cccc(c2)C(F)(F)F)c1 InChI=1S/C24H23F3N6O3S/c1-28-37(34,35)17-5-6-21(33-7-9-36-10-8-33)20(12-17)32-23-18-13-19(31-22(18)29-14-30-23)15-3-2-4-16(11-15)24(25,26)27/h2-6,11-14,28H,7-10H2,1H3,(H2,29,30,31,32) KTIDFNQTLHQGAM-UHFFFAOYSA-N 50118388 CHEMBL3613309 Serine/threonine-protein kinase B-raf Homo sapiens 1.3 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118388&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54675473 104011706 CHEMBL3613309 ZINC00038943 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408805 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cnc23)c1 InChI=1S/C12H12N6O2S/c1-13-21(19,20)9-4-2-3-8(5-9)18-12-10-11(15-6-14-10)16-7-17-12/h2-7,13H,1H3,(H2,14,15,16,17,18) ONVDHHGLDDAZRU-UHFFFAOYSA-N 50118389 CHEMBL3612641 Serine/threonine-protein kinase B-raf Homo sapiens 32 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118389&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 4CW 4YFI 54675470 104011707 CHEMBL3612641 C02860 ZINC13491193 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408806 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]ccc23)c1 InChI=1S/C13H13N5O2S/c1-14-21(19,20)10-4-2-3-9(7-10)18-13-11-5-6-15-12(11)16-8-17-13/h2-8,14H,1H3,(H2,15,16,17,18) OOBRVBGRWPCKGK-UHFFFAOYSA-N 50118396 CHEMBL3612647 Serine/threonine-protein kinase B-raf Homo sapiens 50 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118396&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67995854 104011714 CHEMBL3612647 ZINC13491186 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408807 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(C)c23)c1 InChI=1S/C14H15N5O2S/c1-9-7-16-13-12(9)14(18-8-17-13)19-10-4-3-5-11(6-10)22(20,21)15-2/h3-8,15H,1-2H3,(H2,16,17,18,19) BLOGYXPMEFIABI-UHFFFAOYSA-N 50118411 CHEMBL3612661 Serine/threonine-protein kinase B-raf Homo sapiens 63 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118411&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67995742 104011729 CHEMBL3612661 ZINC96300787 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408808 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(C(C)C)c23)c1 InChI=1S/C16H19N5O2S/c1-10(2)13-8-18-15-14(13)16(20-9-19-15)21-11-5-4-6-12(7-11)24(22,23)17-3/h4-10,17H,1-3H3,(H2,18,19,20,21) MGDKKLPMXIEOJN-UHFFFAOYSA-N 50118413 CHEMBL3612662 Serine/threonine-protein kinase B-raf Homo sapiens 79 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118413&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54675444 104011731 CHEMBL3612662 ZINC27425594 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408810 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(F)c23)c1 InChI=1S/C13H12FN5O2S/c1-15-22(20,21)9-4-2-3-8(5-9)19-13-11-10(14)6-16-12(11)17-7-18-13/h2-7,15H,1H3,(H2,16,17,18,19) BROIYLJWUMQYQV-UHFFFAOYSA-N 50118415 CHEMBL3612664 Serine/threonine-protein kinase B-raf Homo sapiens 79 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118415&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67996103 104011733 CHEMBL3612664 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408811 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(Cl)c23)c1 InChI=1S/C13H12ClN5O2S/c1-15-22(20,21)9-4-2-3-8(5-9)19-13-11-10(14)6-16-12(11)17-7-18-13/h2-7,15H,1H3,(H2,16,17,18,19) MCLHLDXITKQYFX-UHFFFAOYSA-N 50118416 CHEMBL3612665 Serine/threonine-protein kinase B-raf Homo sapiens 13 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118416&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67995947 104011734 CHEMBL3612665 ZINC96300796 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408812 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(Br)c23)c1 InChI=1S/C13H12BrN5O2S/c1-15-22(20,21)9-4-2-3-8(5-9)19-13-11-10(14)6-16-12(11)17-7-18-13/h2-7,15H,1H3,(H2,16,17,18,19) KVTPQZZMIHGOTJ-UHFFFAOYSA-N 50118417 CHEMBL3612666 Serine/threonine-protein kinase B-raf Homo sapiens 5.0 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118417&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67996004 104011735 CHEMBL3612666 ZINC96300800 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408813 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4ccccc4)c23)c1 InChI=1S/C19H17N5O2S/c1-20-27(25,26)15-9-5-8-14(10-15)24-19-17-16(13-6-3-2-4-7-13)11-21-18(17)22-12-23-19/h2-12,20H,1H3,(H2,21,22,23,24) UCBHSPGNEZCSHN-UHFFFAOYSA-N 50118418 CHEMBL3612667 Serine/threonine-protein kinase B-raf Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118418&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67996588 104011736 CHEMBL3612667 ZINC37858407 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408814 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4ccccc4Cl)c23)c1 InChI=1S/C19H16ClN5O2S/c1-21-28(26,27)13-6-4-5-12(9-13)25-19-17-15(10-22-18(17)23-11-24-19)14-7-2-3-8-16(14)20/h2-11,21H,1H3,(H2,22,23,24,25) FTJOQDUGAGFHMY-UHFFFAOYSA-N 50118419 CHEMBL3613176 Serine/threonine-protein kinase B-raf Homo sapiens 10.0 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118419&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54675413 104011737 CHEMBL3613176 ZINC27419292 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408815 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4cccc(Cl)c4)c23)c1 InChI=1S/C19H16ClN5O2S/c1-21-28(26,27)15-7-3-6-14(9-15)25-19-17-16(10-22-18(17)23-11-24-19)12-4-2-5-13(20)8-12/h2-11,21H,1H3,(H2,22,23,24,25) APTZOLCMZQNBAH-UHFFFAOYSA-N 50118420 CHEMBL3613177 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118420&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70648685 104011738 CHEMBL3613177 ZINC37858409 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408816 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4ccc(Cl)cc4)c23)c1 InChI=1S/C19H16ClN5O2S/c1-21-28(26,27)15-4-2-3-14(9-15)25-19-17-16(10-22-18(17)23-11-24-19)12-5-7-13(20)8-6-12/h2-11,21H,1H3,(H2,22,23,24,25) GRKHWSIIZZRHBT-UHFFFAOYSA-N 50118421 CHEMBL3613178 Serine/threonine-protein kinase B-raf Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118421&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70648329 104011739 CHEMBL3613178 ZINC37858411 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408817 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4ccc(OC)cc4)c23)c1 InChI=1S/C20H19N5O3S/c1-21-29(26,27)16-5-3-4-14(10-16)25-20-18-17(11-22-19(18)23-12-24-20)13-6-8-15(28-2)9-7-13/h3-12,21H,1-2H3,(H2,22,23,24,25) YJPQMIQMTGFJMV-UHFFFAOYSA-N 50118422 CHEMBL3613179 Serine/threonine-protein kinase B-raf Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118422&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70649115 104011740 CHEMBL3613179 ZINC96300804 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408818 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4ccncc4)c23)c1 InChI=1S/C18H16N6O2S/c1-19-27(25,26)14-4-2-3-13(9-14)24-18-16-15(12-5-7-20-8-6-12)10-21-17(16)22-11-23-18/h2-11,19H,1H3,(H2,21,22,23,24) FLWDQXQPTMVOLP-UHFFFAOYSA-N 50118423 CHEMBL3613180 Serine/threonine-protein kinase B-raf Homo sapiens 32 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118423&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70649102 104011741 CHEMBL3613180 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408819 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4ccc(CN)cc4)c23)c1 InChI=1S/C20H20N6O2S/c1-22-29(27,28)16-4-2-3-15(9-16)26-20-18-17(11-23-19(18)24-12-25-20)14-7-5-13(10-21)6-8-14/h2-9,11-12,22H,10,21H2,1H3,(H2,23,24,25,26) GMVVBHGDCSWBIU-UHFFFAOYSA-N 50118424 CHEMBL3613181 Serine/threonine-protein kinase B-raf Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118424&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70648331 104011742 CHEMBL3613181 ZINC27422408 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408820 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4ccc(cc4)C(O)=O)c23)c1 InChI=1S/C20H17N5O4S/c1-21-30(28,29)15-4-2-3-14(9-15)25-19-17-16(10-22-18(17)23-11-24-19)12-5-7-13(8-6-12)20(26)27/h2-11,21H,1H3,(H,26,27)(H2,22,23,24,25) FNRKRAHEJJODJT-UHFFFAOYSA-N 50118426 CHEMBL3613182 Serine/threonine-protein kinase B-raf Homo sapiens 16 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118426&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67991931 104011744 CHEMBL3613182 ZINC27420597 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408821 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(Br)cc23)c1 InChI=1S/C13H12BrN5O2S/c1-15-22(20,21)9-4-2-3-8(5-9)18-12-10-6-11(14)19-13(10)17-7-16-12/h2-7,15H,1H3,(H2,16,17,18,19) CGGLCGPBRBEBNW-UHFFFAOYSA-N 50118427 CHEMBL3613183 Serine/threonine-protein kinase B-raf Homo sapiens 16 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118427&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54675446 104011745 CHEMBL3613183 ZINC27426784 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408822 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(cc23)-c2ccccc2)c1 InChI=1S/C19H17N5O2S/c1-20-27(25,26)15-9-5-8-14(10-15)23-18-16-11-17(13-6-3-2-4-7-13)24-19(16)22-12-21-18/h2-12,20H,1H3,(H2,21,22,23,24) ZDCFCBAJUCODDS-UHFFFAOYSA-N 50118428 CHEMBL3613184 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118428&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67996291 104011746 CHEMBL3613184 ZINC27422943 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408823 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(cc23)-c2ccccc2C)c1 InChI=1S/C20H19N5O2S/c1-13-6-3-4-9-16(13)18-11-17-19(22-12-23-20(17)25-18)24-14-7-5-8-15(10-14)28(26,27)21-2/h3-12,21H,1-2H3,(H2,22,23,24,25) QVQALZRFHOCGOG-UHFFFAOYSA-N 50118429 CHEMBL3613185 Serine/threonine-protein kinase B-raf Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118429&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70649129 104011747 CHEMBL3613185 ZINC27420611 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408824 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(cc23)-c2cccc(C)c2)c1 InChI=1S/C20H19N5O2S/c1-13-5-3-6-14(9-13)18-11-17-19(22-12-23-20(17)25-18)24-15-7-4-8-16(10-15)28(26,27)21-2/h3-12,21H,1-2H3,(H2,22,23,24,25) SPPKDDHWXPUFAA-UHFFFAOYSA-N 50118464 CHEMBL3613186 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118464&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67995956 104011782 CHEMBL3613186 ZINC13491270 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408809 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(CC(C)C)c23)c1 InChI=1S/C17H21N5O2S/c1-11(2)7-12-9-19-16-15(12)17(21-10-20-16)22-13-5-4-6-14(8-13)25(23,24)18-3/h4-6,8-11,18H,7H2,1-3H3,(H2,19,20,21,22) ARMYNGCDLOKDLO-UHFFFAOYSA-N 50118414 CHEMBL3612663 Serine/threonine-protein kinase B-raf Homo sapiens 40 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118414&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67995748 104011732 CHEMBL3612663 ZINC96300791 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408944 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(cc23)-c2ccc(C)cc2)c1 InChI=1S/C20H19N5O2S/c1-13-6-8-14(9-7-13)18-11-17-19(22-12-23-20(17)25-18)24-15-4-3-5-16(10-15)28(26,27)21-2/h3-12,21H,1-2H3,(H2,22,23,24,25) VFQPSAHXVPLCEP-UHFFFAOYSA-N 50118465 CHEMBL3613187 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118465&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70649110 104011783 CHEMBL3613187 ZINC13491276 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408946 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(cc23)-c2cccc(c2)C(F)(F)F)c1 InChI=1S/C20H16F3N5O2S/c1-24-31(29,30)15-7-3-6-14(9-15)27-18-16-10-17(28-19(16)26-11-25-18)12-4-2-5-13(8-12)20(21,22)23/h2-11,24H,1H3,(H2,25,26,27,28) ICLSHNIWDHMQDD-UHFFFAOYSA-N 50118466 CHEMBL3613188 Serine/threonine-protein kinase B-raf Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118466&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67996483 104011784 CHEMBL3613188 ZINC03960338 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408947 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(cc23)-c2ccc(O)cc2)c1 InChI=1S/C19H17N5O3S/c1-20-28(26,27)15-4-2-3-13(9-15)23-18-16-10-17(24-19(16)22-11-21-18)12-5-7-14(25)8-6-12/h2-11,20,25H,1H3,(H2,21,22,23,24) DABNWVFIPGBOEE-UHFFFAOYSA-N 50118467 CHEMBL3613189 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118467&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70649136 104011785 CHEMBL3613189 ZINC13491278 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408948 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(cc23)-c2ccncc2)c1 InChI=1S/C18H16N6O2S/c1-19-27(25,26)14-4-2-3-13(9-14)23-17-15-10-16(12-5-7-20-8-6-12)24-18(15)22-11-21-17/h2-11,19H,1H3,(H2,21,22,23,24) UKXBJWFWOIBXLA-UHFFFAOYSA-N 50118468 CHEMBL3613190 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118468&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70649109 104011786 CHEMBL3613190 ZINC13491272 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408949 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(cc23)C(O)=O)c1 InChI=1S/C14H13N5O4S/c1-15-24(22,23)9-4-2-3-8(5-9)18-12-10-6-11(14(20)21)19-13(10)17-7-16-12/h2-7,15H,1H3,(H,20,21)(H2,16,17,18,19) AYUVTOFTSPATMT-UHFFFAOYSA-N 50118469 CHEMBL3612079 Serine/threonine-protein kinase B-raf Homo sapiens 40 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118469&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54675418 104011787 CHEMBL3612079 ZINC13491280 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408950 CNS(=O)(=O)c1ccc(Cl)c(Nc2ncnc3[nH]ccc23)c1 InChI=1S/C13H12ClN5O2S/c1-15-22(20,21)8-2-3-10(14)11(6-8)19-13-9-4-5-16-12(9)17-7-18-13/h2-7,15H,1H3,(H2,16,17,18,19) SLDWVUQGWUNROC-UHFFFAOYSA-N 50118472 CHEMBL3613193 Serine/threonine-protein kinase B-raf Homo sapiens 32 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118472&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54675261 104011790 CHEMBL3613193 ZINC03960339 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408951 CNc1ccc(cc1Nc1ncnc2[nH]ccc12)S(=O)(=O)NC InChI=1S/C14H16N6O2S/c1-15-11-4-3-9(23(21,22)16-2)7-12(11)20-14-10-5-6-17-13(10)18-8-19-14/h3-8,15-16H,1-2H3,(H2,17,18,19,20) GHNAHBBVAPPKKC-UHFFFAOYSA-N 50118473 CHEMBL3613194 Serine/threonine-protein kinase B-raf Homo sapiens 1000 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118473&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70649137 104011791 CHEMBL3613194 ZINC13491266 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408952 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]ccc23)c1 InChI=1S/C15H18N6O2S/c1-16-24(22,23)10-4-5-13(21(2)3)12(8-10)20-15-11-6-7-17-14(11)18-9-19-15/h4-9,16H,1-3H3,(H2,17,18,19,20) FRRDBCZMMUBGNF-UHFFFAOYSA-N 50118379 CHEMBL3613195 Serine/threonine-protein kinase B-raf Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118379&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70648666 104011697 CHEMBL3613195 ZINC13491207 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408953 CNS(=O)(=O)c1ccc(N2CCOCC2)c(Nc2ncnc3[nH]ccc23)c1 InChI=1S/C17H20N6O3S/c1-18-27(24,25)12-2-3-15(23-6-8-26-9-7-23)14(10-12)22-17-13-4-5-19-16(13)20-11-21-17/h2-5,10-11,18H,6-9H2,1H3,(H2,19,20,21,22) WDWFOYNZUZNVNJ-UHFFFAOYSA-N 50118380 CHEMBL3613196 Serine/threonine-protein kinase B-raf Homo sapiens 8.0 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118380&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70649090 104011698 CHEMBL3613196 ZINC13491203 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408954 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]cc(C)c23)c1 InChI=1S/C16H20N6O2S/c1-10-8-18-15-14(10)16(20-9-19-15)21-12-7-11(25(23,24)17-2)5-6-13(12)22(3)4/h5-9,17H,1-4H3,(H2,18,19,20,21) XCLJGHDOBNHEIT-UHFFFAOYSA-N 50118381 CHEMBL3613197 Serine/threonine-protein kinase B-raf Homo sapiens 0.500000 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118381&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67996169 104011699 CHEMBL3613197 ZINC02573995 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408955 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]cc(Br)c23)c1 InChI=1S/C15H17BrN6O2S/c1-17-25(23,24)9-4-5-12(22(2)3)11(6-9)21-15-13-10(16)7-18-14(13)19-8-20-15/h4-8,17H,1-3H3,(H2,18,19,20,21) JPELQPFYUQYAPX-UHFFFAOYSA-N 50118382 CHEMBL3613198 Serine/threonine-protein kinase B-raf Homo sapiens 0.200000 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118382&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54675374 104011700 CHEMBL3613198 ZINC13491185 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408957 CNS(=O)(=O)c1ccc(N2CCOCC2)c(Nc2ncnc3[nH]cc(C)c23)c1 InChI=1S/C18H22N6O3S/c1-12-10-20-17-16(12)18(22-11-21-17)23-14-9-13(28(25,26)19-2)3-4-15(14)24-5-7-27-8-6-24/h3-4,9-11,19H,5-8H2,1-2H3,(H2,20,21,22,23) KDNOQIGPPRAKPY-UHFFFAOYSA-N 50118383 CHEMBL3613199 Serine/threonine-protein kinase B-raf Homo sapiens 1.3 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118383&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54675336 104011701 CHEMBL3613199 ZINC13491190 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408959 CNS(=O)(=O)c1ccc(N2CCOCC2)c(Nc2ncnc3[nH]cc(Br)c23)c1 InChI=1S/C17H19BrN6O3S/c1-19-28(25,26)11-2-3-14(24-4-6-27-7-5-24)13(8-11)23-17-15-12(18)9-20-16(15)21-10-22-17/h2-3,8-10,19H,4-7H2,1H3,(H2,20,21,22,23) IMXJHHQPHUBYBA-UHFFFAOYSA-N 50118384 CHEMBL3613305 Serine/threonine-protein kinase B-raf Homo sapiens 0.500000 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118384&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 4CV 4YFF 70648683 104011702 CHEMBL3613305 ZINC01933195 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408960 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]c(Br)cc23)c1 InChI=1S/C15H17BrN6O2S/c1-17-25(23,24)9-4-5-12(22(2)3)11(6-9)20-14-10-7-13(16)21-15(10)19-8-18-14/h4-8,17H,1-3H3,(H2,18,19,20,21) QMRCGCBWNRHDTC-UHFFFAOYSA-N 50118385 CHEMBL3613306 Serine/threonine-protein kinase B-raf Homo sapiens 6.3 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118385&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54675419 104011703 CHEMBL3613306 ZINC13491192 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408961 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]c(cc23)-c2cccc(c2)C(F)(F)F)c1 InChI=1S/C22H21F3N6O2S/c1-26-34(32,33)15-7-8-19(31(2)3)18(10-15)30-21-16-11-17(29-20(16)27-12-28-21)13-5-4-6-14(9-13)22(23,24)25/h4-12,26H,1-3H3,(H2,27,28,29,30) CTGTWMKGYMJBNV-UHFFFAOYSA-N 50118386 CHEMBL3613307 Serine/threonine-protein kinase B-raf Homo sapiens 0.600000 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118386&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54675501 104011704 CHEMBL3613307 ZINC13491212 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50408962 CNS(=O)(=O)c1ccc(N2CCOCC2)c(Nc2ncnc3[nH]c(Br)cc23)c1 InChI=1S/C17H19BrN6O3S/c1-19-28(25,26)11-2-3-14(24-4-6-27-7-5-24)13(8-11)22-16-12-9-15(18)23-17(12)21-10-20-16/h2-3,8-10,19H,4-7H2,1H3,(H2,20,21,22,23) CVKDTMOMVBGJJS-UHFFFAOYSA-N 50118387 CHEMBL3613308 Serine/threonine-protein kinase B-raf Homo sapiens 8.0 ChEMBL 10.1021/acs.jmedchem.5b00931 10.7270/Q2FT8NV1 26355916 Lawhorn, BG; Philp, J; Zhao, Y; Louer, C; Hammond, M; Cheung, M; Fries, H; Graves, AP; Shewchuk, L; Wang, L; Cottom, JE; Qi, H; Zhao, H; Totoritis, R; Zhang, G; Schwartz, B; Li, H; Sweitzer, S; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118387&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54675442 104011705 CHEMBL3613308 ZINC13491198 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50414694 CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(NC(=O)c2cnoc2C)c1 InChI=1S/C25H26F3N5O3/c1-15-4-5-19(13-22(15)31-24(35)21-14-29-36-16(21)2)30-23(34)17-10-18(25(26,27)28)12-20(11-17)33-8-6-32(3)7-9-33/h4-5,10-14H,6-9H2,1-3H3,(H,30,34)(H,31,35) XQGUIRKPWAXDLW-UHFFFAOYSA-N 50121690 CHEMBL3616960 Serine/threonine-protein kinase B-raf Homo sapiens 5960 ChEMBL 10.1016/j.ejmech.2015.08.031 10.7270/Q2XG9SXV 26318067 Im, D; Jung, K; Yang, S; Aman, W; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121690&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122189918 319566273 CHEMBL3616960 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50414695 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase B-raf Homo sapiens 14 ChEMBL 10.1016/j.ejmech.2015.08.031 10.7270/Q2XG9SXV 26318067 Im, D; Jung, K; Yang, S; Aman, W; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50414696 CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(NC(=O)c2cnoc2C)c1 InChI=1S/C25H26F3N5O3/c1-15-4-5-19(13-22(15)31-24(35)21-14-29-36-16(21)2)30-23(34)17-10-18(25(26,27)28)12-20(11-17)33-8-6-32(3)7-9-33/h4-5,10-14H,6-9H2,1-3H3,(H,30,34)(H,31,35) XQGUIRKPWAXDLW-UHFFFAOYSA-N 50121690 CHEMBL3616960 Serine/threonine-protein kinase B-raf Homo sapiens 668 ChEMBL 10.1016/j.ejmech.2015.08.031 10.7270/Q2XG9SXV 26318067 Im, D; Jung, K; Yang, S; Aman, W; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121690&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 122189918 319566273 CHEMBL3616960 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50414697 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase B-raf Homo sapiens 4.5 ChEMBL 10.1016/j.ejmech.2015.08.031 10.7270/Q2XG9SXV 26318067 Im, D; Jung, K; Yang, S; Aman, W; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50414984 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 120 ChEMBL 10.1016/j.bmcl.2015.07.082 10.7270/Q2J9686Z 26318998 Diez-Cecilia, E; Carson, R; Kelly, B; van Schaeybroeck, S; Murray, JT; Rozas, I Trinity College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50434172 CCN1CCN(CC\C=C\c2ccc3c(Nc4ccc(Sc5nccn5C)c(Cl)c4)c(cnc3c2)C#N)CC1 InChI=1S/C30H32ClN7S/c1-3-37-14-16-38(17-15-37)12-5-4-6-22-7-9-25-27(18-22)34-21-23(20-32)29(25)35-24-8-10-28(26(31)19-24)39-30-33-11-13-36(30)2/h4,6-11,13,18-19,21H,3,5,12,14-17H2,1-2H3,(H,34,35)/b6-4+ OYAMULIHRWEUAR-GQCTYLIASA-N 50274385 4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]phenyl}-amino)-7-[(1E)-4-(4-ethylpiperazin-1-yl)but-1-enyl]quinoline-3-carbonitrile::CHEMBL489058 Serine/threonine-protein kinase B-raf Homo sapiens 8800 ChEMBL 10.1016/j.bmc.2008.09.009 10.7270/Q2DJ5FGD 18815050 Berger, DM; Dutia, M; Powell, D; Floyd, MB; Torres, N; Mallon, R; Wojciechowicz, D; Kim, S; Feldberg, L; Collins, K; Chaudhary, I Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274385&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25211064 104118179 CHEMBL489058 ZINC49877677 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50447823 Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(c1=O)S(=O)(=O)c1ccc(F)cc1F InChI=1S/C22H15F2N5O3S/c1-29-20-13(9-19(21(29)30)33(31,32)18-5-2-14(23)10-16(18)24)11-26-22(28-20)27-15-3-4-17-12(8-15)6-7-25-17/h2-11,25H,1H3,(H,26,27,28) ZEHBZHZMQSHZFI-UHFFFAOYSA-N 50135286 CHEMBL3745885 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.11.045 10.7270/Q24Q7WT8 26762835 Reddy, MV; Akula, B; Jatiani, S; Vasquez-Del Carpio, R; Billa, VK; Mallireddigari, MR; Cosenza, SC; Venkata Subbaiah, DR; Bharathi, EV; Pallela, VR; Ramkumar, P; Jain, R; Aggarwal, AK; Reddy, EP Icahn School of Medicine at Mount Sinai http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50135286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50135286&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67240318 336951802 CHEMBL3745885 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453316 CCCS(=O)(=O)Nc1ccc(F)c(c1F)-c1ccc2cc(N)ncc2c1 InChI=1S/C18H17F2N3O2S/c1-2-7-26(24,25)23-15-6-5-14(19)17(18(15)20)12-4-3-11-9-16(21)22-10-13(11)8-12/h3-6,8-10,23H,2,7H2,1H3,(H2,21,22) ARJQWXGFNXYBIQ-UHFFFAOYSA-N 50139054 CHEMBL2023335 Serine/threonine-protein kinase B-raf Homo sapiens 8.7 ChEMBL 10.1016/j.bmcl.2015.12.086 10.7270/Q2W097S9 26739779 Lu, B; Cao, H; Cao, J; Huang, S; Hu, Q; Liu, D; Shen, R; Shen, X; Tao, W; Wan, H; Wang, D; Yan, Y; Yang, L; Zhang, J; Zhang, L; Zhang, L; Zhang, M Shanghai Hengrui Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139054&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70696122 336952175 CHEMBL2023335 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453317 CCCS(=O)(=O)Nc1ccc(F)c(c1F)-c1ccc2cc(NC[C@@H](C)NC(=O)OC)ncc2c1 InChI=1S/C23H26F2N4O4S/c1-4-9-34(31,32)29-19-8-7-18(24)21(22(19)25)16-6-5-15-11-20(27-13-17(15)10-16)26-12-14(2)28-23(30)33-3/h5-8,10-11,13-14,29H,4,9,12H2,1-3H3,(H,26,27)(H,28,30)/t14-/m1/s1 MJKJTOBDFGGWCD-CQSZACIVSA-N 50139055 CHEMBL3754116 Serine/threonine-protein kinase B-raf Homo sapiens >30 ChEMBL 10.1016/j.bmcl.2015.12.086 10.7270/Q2W097S9 26739779 Lu, B; Cao, H; Cao, J; Huang, S; Hu, Q; Liu, D; Shen, R; Shen, X; Tao, W; Wan, H; Wang, D; Yan, Y; Yang, L; Zhang, J; Zhang, L; Zhang, L; Zhang, M Shanghai Hengrui Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139055&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127026035 336952176 CHEMBL3754116 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453318 CCCS(=O)(=O)Nc1ccc(F)c(c1F)-c1ccc2cc(NC[C@H](C)NC(=O)OC)ncc2c1 InChI=1S/C23H26F2N4O4S/c1-4-9-34(31,32)29-19-8-7-18(24)21(22(19)25)16-6-5-15-11-20(27-13-17(15)10-16)26-12-14(2)28-23(30)33-3/h5-8,10-11,13-14,29H,4,9,12H2,1-3H3,(H,26,27)(H,28,30)/t14-/m0/s1 MJKJTOBDFGGWCD-AWEZNQCLSA-N 50139056 CHEMBL3754618 Serine/threonine-protein kinase B-raf Homo sapiens 0.800000 ChEMBL 10.1016/j.bmcl.2015.12.086 10.7270/Q2W097S9 26739779 Lu, B; Cao, H; Cao, J; Huang, S; Hu, Q; Liu, D; Shen, R; Shen, X; Tao, W; Wan, H; Wang, D; Yan, Y; Yang, L; Zhang, J; Zhang, L; Zhang, L; Zhang, M Shanghai Hengrui Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139056&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73425627 336952177 CHEMBL3754618 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453319 CCCS(=O)(=O)Nc1ccc(F)c(c1F)-c1cc2cnc(N)cc2cc1OC InChI=1S/C19H19F2N3O3S/c1-3-6-28(25,26)24-15-5-4-14(20)18(19(15)21)13-7-12-10-23-17(22)9-11(12)8-16(13)27-2/h4-5,7-10,24H,3,6H2,1-2H3,(H2,22,23) HILKHCSSTCIPDV-UHFFFAOYSA-N 50139057 CHEMBL3752762 Serine/threonine-protein kinase B-raf Homo sapiens 0.800000 ChEMBL 10.1016/j.bmcl.2015.12.086 10.7270/Q2W097S9 26739779 Lu, B; Cao, H; Cao, J; Huang, S; Hu, Q; Liu, D; Shen, R; Shen, X; Tao, W; Wan, H; Wang, D; Yan, Y; Yang, L; Zhang, J; Zhang, L; Zhang, L; Zhang, M Shanghai Hengrui Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139057&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73425628 104029036 CHEMBL3752762 ZINC43911078 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453320 CCCS(=O)(=O)Nc1ccc(F)c(c1F)-c1cc2cnc(NC[C@H](C)NC(=O)OC)cc2cc1OC InChI=1S/C24H28F2N4O5S/c1-5-8-36(32,33)30-19-7-6-18(25)22(23(19)26)17-9-16-13-28-21(11-15(16)10-20(17)34-3)27-12-14(2)29-24(31)35-4/h6-7,9-11,13-14,30H,5,8,12H2,1-4H3,(H,27,28)(H,29,31)/t14-/m0/s1 HPLIVFZYIUPVFO-AWEZNQCLSA-N 50139058 CHEMBL3752213 Serine/threonine-protein kinase B-raf Homo sapiens 0.100000 ChEMBL 10.1016/j.bmcl.2015.12.086 10.7270/Q2W097S9 26739779 Lu, B; Cao, H; Cao, J; Huang, S; Hu, Q; Liu, D; Shen, R; Shen, X; Tao, W; Wan, H; Wang, D; Yan, Y; Yang, L; Zhang, J; Zhang, L; Zhang, L; Zhang, M Shanghai Hengrui Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139058&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73425629 104029037 CHEMBL3752213 ZINC44280969 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453321 CCCS(=O)(=O)Nc1ccc(F)c(c1F)-c1cc2cnc(NC[C@H](C)NC(=O)OC)cc2cc1CC InChI=1S/C25H30F2N4O4S/c1-5-9-36(33,34)31-21-8-7-20(26)23(24(21)27)19-11-18-14-29-22(12-17(18)10-16(19)6-2)28-13-15(3)30-25(32)35-4/h7-8,10-12,14-15,31H,5-6,9,13H2,1-4H3,(H,28,29)(H,30,32)/t15-/m0/s1 QHWGGIDIMHBKTC-HNNXBMFYSA-N 50139059 CHEMBL3753260 Serine/threonine-protein kinase B-raf Homo sapiens 0.600000 ChEMBL 10.1016/j.bmcl.2015.12.086 10.7270/Q2W097S9 26739779 Lu, B; Cao, H; Cao, J; Huang, S; Hu, Q; Liu, D; Shen, R; Shen, X; Tao, W; Wan, H; Wang, D; Yan, Y; Yang, L; Zhang, J; Zhang, L; Zhang, L; Zhang, M Shanghai Hengrui Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139059&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73425728 336952178 CHEMBL3753260 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453322 CCCS(=O)(=O)Nc1ccc(F)c(c1F)-c1cc2cnc3[nH]ncc3c2cc1OC InChI=1S/C20H18F2N4O3S/c1-3-6-30(27,28)26-16-5-4-15(21)18(19(16)22)13-7-11-9-23-20-14(10-24-25-20)12(11)8-17(13)29-2/h4-5,7-10,26H,3,6H2,1-2H3,(H,23,24,25) VPAQTCKWOOMLRP-UHFFFAOYSA-N 50139060 CHEMBL3753663 Serine/threonine-protein kinase B-raf Homo sapiens 70 ChEMBL 10.1016/j.bmcl.2015.12.086 10.7270/Q2W097S9 26739779 Lu, B; Cao, H; Cao, J; Huang, S; Hu, Q; Liu, D; Shen, R; Shen, X; Tao, W; Wan, H; Wang, D; Yan, Y; Yang, L; Zhang, J; Zhang, L; Zhang, L; Zhang, M Shanghai Hengrui Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139060&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73427048 336952179 CHEMBL3753663 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50455513 Oc1cc(CNC=C2C(=O)NC(=O)c3ccc(I)cc23)ccc1-c1ccoc1 InChI=1S/C21H15IN2O4/c22-14-2-4-16-17(8-14)18(21(27)24-20(16)26)10-23-9-12-1-3-15(19(25)7-12)13-5-6-28-11-13/h1-8,10-11,23,25H,9H2,(H,24,26,27) CUISPPCDYZFGCY-UHFFFAOYSA-N 50267255 4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]-6-iodo-4Hisoquinoline-1,3-dione::CHEMBL504547 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1021/jm801026e 10.7270/Q27H1JG7 19317452 Tsou, HR; Liu, X; Birnberg, G; Kaplan, J; Otteng, M; Tran, T; Kutterer, K; Tang, Z; Suayan, R; Zask, A; Ravi, M; Bretz, A; Grillo, M; McGinnis, JP; Rabindran, SK; Ayral-Kaloustian, S; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50267255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50267255&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 42625986 104114157 CHEMBL504547 ZINC40981103 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453392 Cl.Cl.CCNCc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H29F3N4O3.2ClH/c1-2-33-16-17-11-20(13-21(12-17)29(30,31)32)28(38)35-22-5-3-18-4-6-23(15-19(18)14-22)39-25-9-10-34-27-24(25)7-8-26(37)36-27;;/h4,6,9-13,15,22,33H,2-3,5,7-8,14,16H2,1H3,(H,35,38)(H,34,36,37);2*1H/t22-;;/m1../s1 PEOJMACLKYXLPT-GJICFQLNSA-N 50139147 CHEMBL3765509 Serine/threonine-protein kinase B-raf Homo sapiens 1.9 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139147&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039872 336952228 CHEMBL3765509 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453393 Cl.Cl.NCc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C27H25F3N4O3.2ClH/c28-27(29,30)19-10-15(14-31)9-18(11-19)26(36)33-20-3-1-16-2-4-21(13-17(16)12-20)37-23-7-8-32-25-22(23)5-6-24(35)34-25;;/h2,4,7-11,13,20H,1,3,5-6,12,14,31H2,(H,33,36)(H,32,34,35);2*1H/t20-;;/m1../s1 LWVGDBMVZYRODI-FAVHNTAZSA-N 50139148 CHEMBL3764101 Serine/threonine-protein kinase B-raf Homo sapiens 2.9 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139148&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039873 336952229 CHEMBL3764101 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453394 CC(C)(N)c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H29F3N4O3/c1-28(2,33)19-11-18(12-20(15-19)29(30,31)32)27(38)35-21-5-3-16-4-6-22(14-17(16)13-21)39-24-9-10-34-26-23(24)7-8-25(37)36-26/h4,6,9-12,14-15,21H,3,5,7-8,13,33H2,1-2H3,(H,35,38)(H,34,36,37)/t21-/m1/s1 GXEGTVQATHKFDH-OAQYLSRUSA-N 50339608 3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide::CHEMBL1688861 Serine/threonine-protein kinase B-raf Homo sapiens 2.1 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339608&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 50992247 125089710 CHEMBL1688861 ZINC66128696 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453395 Cl.Cl.NC1(CCC1)c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C30H29F3N4O3.2ClH/c31-30(32,33)21-13-19(12-20(16-21)29(34)9-1-10-29)28(39)36-22-4-2-17-3-5-23(15-18(17)14-22)40-25-8-11-35-27-24(25)6-7-26(38)37-27;;/h3,5,8,11-13,15-16,22H,1-2,4,6-7,9-10,14,34H2,(H,36,39)(H,35,37,38);2*1H/t22-;;/m1../s1 QWYNJGPOKODWOW-GJICFQLNSA-N 50139149 CHEMBL3765012 Serine/threonine-protein kinase B-raf Homo sapiens 1.8 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139149&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127038886 336952230 CHEMBL3765012 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453396 Cl.N[C@H](CO)c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C28H27F3N4O4.ClH/c29-28(30,31)19-10-17(23(32)14-36)9-18(11-19)27(38)34-20-3-1-15-2-4-21(13-16(15)12-20)39-24-7-8-33-26-22(24)5-6-25(37)35-26;/h2,4,7-11,13,20,23,36H,1,3,5-6,12,14,32H2,(H,34,38)(H,33,35,37);1H/t20-,23-;/m1./s1 HPOLRKQDHHIYBD-KFWGXXPESA-N 50139150 CHEMBL3763999 Serine/threonine-protein kinase B-raf Homo sapiens 1.7 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139150&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039874 336952231 CHEMBL3763999 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453397 Cl.Cl.OC1(CNC1)c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H27F3N4O4.2ClH/c30-29(31,32)20-10-18(9-19(13-20)28(39)14-33-15-28)27(38)35-21-3-1-16-2-4-22(12-17(16)11-21)40-24-7-8-34-26-23(24)5-6-25(37)36-26;;/h2,4,7-10,12-13,21,33,39H,1,3,5-6,11,14-15H2,(H,35,38)(H,34,36,37);2*1H/t21-;;/m1../s1 ZLLIDYXIKGEGQI-GHVWMZMZSA-N 50139151 CHEMBL3764870 Serine/threonine-protein kinase B-raf Homo sapiens 2.2 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139151&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039875 336952232 CHEMBL3764870 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453398 OCC1COCCN1Cc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C32H33F3N4O5/c33-32(34,35)23-12-19(16-39-9-10-43-18-25(39)17-40)11-22(13-23)31(42)37-24-3-1-20-2-4-26(15-21(20)14-24)44-28-7-8-36-30-27(28)5-6-29(41)38-30/h2,4,7-8,11-13,15,24-25,40H,1,3,5-6,9-10,14,16-18H2,(H,37,42)(H,36,38,41)/t24-,25?/m1/s1 PVXTZQASVQOJKV-IKOFQBKESA-N 50139152 CHEMBL3764275 Serine/threonine-protein kinase B-raf Homo sapiens 4.0 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139152&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127038548 336952233 CHEMBL3764275 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453399 FC(F)(F)c1cc(cc(c1)-c1cnc[nH]1)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H24F3N5O3/c30-29(31,32)20-10-18(24-14-33-15-35-24)9-19(11-20)28(39)36-21-3-1-16-2-4-22(13-17(16)12-21)40-25-7-8-34-27-23(25)5-6-26(38)37-27/h2,4,7-11,13-15,21H,1,3,5-6,12H2,(H,33,35)(H,36,39)(H,34,37,38)/t21-/m1/s1 AZGJHEXVDFPTCF-OAQYLSRUSA-N 50139153 CHEMBL3765355 Serine/threonine-protein kinase B-raf Homo sapiens 2.0 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139153&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039876 336952234 CHEMBL3765355 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453400 FC(F)(F)c1cc(cc(c1)-c1cc[nH]n1)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H24F3N5O3/c30-29(31,32)20-12-18(24-7-10-34-37-24)11-19(13-20)28(39)35-21-3-1-16-2-4-22(15-17(16)14-21)40-25-8-9-33-27-23(25)5-6-26(38)36-27/h2,4,7-13,15,21H,1,3,5-6,14H2,(H,34,37)(H,35,39)(H,33,36,38)/t21-/m1/s1 QPMHNEWPHATGSK-OAQYLSRUSA-N 50139154 CHEMBL3765074 Serine/threonine-protein kinase B-raf Homo sapiens 9.5 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139154&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127041188 336952235 CHEMBL3765074 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453401 Cl.FC(F)(F)c1cc(cc(c1)-c1cn[nH]c1)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H24F3N5O3.ClH/c30-29(31,32)21-10-17(20-14-34-35-15-20)9-19(11-21)28(39)36-22-3-1-16-2-4-23(13-18(16)12-22)40-25-7-8-33-27-24(25)5-6-26(38)37-27;/h2,4,7-11,13-15,22H,1,3,5-6,12H2,(H,34,35)(H,36,39)(H,33,37,38);1H/t22-;/m1./s1 LUWQBNYXTXXQTG-VZYDHVRKSA-N 50139155 CHEMBL3765708 Serine/threonine-protein kinase B-raf Homo sapiens 2.9 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139155&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039247 336952236 CHEMBL3765708 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453402 Cl.Cl.Cn1cnc(c1)-c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C30H26F3N5O3.2ClH/c1-38-15-25(35-16-38)19-10-20(12-21(11-19)30(31,32)33)29(40)36-22-4-2-17-3-5-23(14-18(17)13-22)41-26-8-9-34-28-24(26)6-7-27(39)37-28;;/h3,5,8-12,14-16,22H,2,4,6-7,13H2,1H3,(H,36,40)(H,34,37,39);2*1H/t22-;;/m1../s1 JNPDPRNGEUSPRB-GJICFQLNSA-N 50139156 CHEMBL3763694 Serine/threonine-protein kinase B-raf Homo sapiens 2.1 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139156&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039248 336952237 CHEMBL3763694 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453403 Cl.Cn1nccc1-c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C30H26F3N5O3.ClH/c1-38-25(8-11-35-38)19-12-20(14-21(13-19)30(31,32)33)29(40)36-22-4-2-17-3-5-23(16-18(17)15-22)41-26-9-10-34-28-24(26)6-7-27(39)37-28;/h3,5,8-14,16,22H,2,4,6-7,15H2,1H3,(H,36,40)(H,34,37,39);1H/t22-;/m1./s1 QCOWBGMSPURULY-VZYDHVRKSA-N 50139157 CHEMBL3764588 Serine/threonine-protein kinase B-raf Homo sapiens 1.5 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139157&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039249 336952238 CHEMBL3764588 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453404 Cl.Cn1cc(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C30H26F3N5O3.ClH/c1-38-16-21(15-35-38)18-10-20(12-22(11-18)30(31,32)33)29(40)36-23-4-2-17-3-5-24(14-19(17)13-23)41-26-8-9-34-28-25(26)6-7-27(39)37-28;/h3,5,8-12,14-16,23H,2,4,6-7,13H2,1H3,(H,36,40)(H,34,37,39);1H/t23-;/m1./s1 BTMLMFGWUXYUEE-GNAFDRTKSA-N 50139158 CHEMBL3763646 Serine/threonine-protein kinase B-raf Homo sapiens 2.1 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139158&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039250 336952239 CHEMBL3763646 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453405 CN(C)Cc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H29F3N4O3/c1-36(2)16-17-11-20(13-21(12-17)29(30,31)32)28(38)34-22-5-3-18-4-6-23(15-19(18)14-22)39-25-9-10-33-27-24(25)7-8-26(37)35-27/h4,6,9-13,15,22H,3,5,7-8,14,16H2,1-2H3,(H,34,38)(H,33,35,37)/t22-/m1/s1 DZUFTTMDQLYMBE-JOCHJYFZSA-N 50339609 3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide::CHEMBL1688860 Serine/threonine-protein kinase B-raf Homo sapiens 48 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339609&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 50990961 125089711 CHEMBL1688860 ZINC66128693 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453406 FC(F)(F)c1cccc(c1)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C26H22F3N3O3/c27-26(28,29)18-3-1-2-16(12-18)25(34)31-19-6-4-15-5-7-20(14-17(15)13-19)35-22-10-11-30-24-21(22)8-9-23(33)32-24/h1-3,5,7,10-12,14,19H,4,6,8-9,13H2,(H,31,34)(H,30,32,33)/t19-/m1/s1 VWDIIVROCTXOMH-LJQANCHMSA-N 50139159 CHEMBL3765596 Serine/threonine-protein kinase B-raf Homo sapiens 487 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139159&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127042768 336952240 CHEMBL3765596 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453407 CNCc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C28H27F3N4O3/c1-32-15-16-10-19(12-20(11-16)28(29,30)31)27(37)34-21-4-2-17-3-5-22(14-18(17)13-21)38-24-8-9-33-26-23(24)6-7-25(36)35-26/h3,5,8-12,14,21,32H,2,4,6-7,13,15H2,1H3,(H,34,37)(H,33,35,36)/t21-/m1/s1 CHOXZXLXXUVMGG-OAQYLSRUSA-N 50339621 3-[(methylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide::CHEMBL1688876 Serine/threonine-protein kinase B-raf Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339621&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51355461 125089723 CHEMBL1688876 ZINC66112621 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453408 Cl.Cl.CCNCc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H29F3N4O3.2ClH/c1-2-33-16-17-11-20(13-21(12-17)29(30,31)32)28(38)35-22-5-3-18-4-6-23(15-19(18)14-22)39-25-9-10-34-27-24(25)7-8-26(37)36-27;;/h4,6,9-13,15,22,33H,2-3,5,7-8,14,16H2,1H3,(H,35,38)(H,34,36,37);2*1H/t22-;;/m1../s1 PEOJMACLKYXLPT-GJICFQLNSA-N 50139147 CHEMBL3765509 Serine/threonine-protein kinase B-raf Homo sapiens 56 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139147&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039872 336952228 CHEMBL3765509 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453409 Cl.Cl.NCc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C27H25F3N4O3.2ClH/c28-27(29,30)19-10-15(14-31)9-18(11-19)26(36)33-20-3-1-16-2-4-21(13-17(16)12-20)37-23-7-8-32-25-22(23)5-6-24(35)34-25;;/h2,4,7-11,13,20H,1,3,5-6,12,14,31H2,(H,33,36)(H,32,34,35);2*1H/t20-;;/m1../s1 LWVGDBMVZYRODI-FAVHNTAZSA-N 50139148 CHEMBL3764101 Serine/threonine-protein kinase B-raf Homo sapiens 274 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139148&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039873 336952229 CHEMBL3764101 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453410 CC(C)(N)c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H29F3N4O3/c1-28(2,33)19-11-18(12-20(15-19)29(30,31)32)27(38)35-21-5-3-16-4-6-22(14-17(16)13-21)39-24-9-10-34-26-23(24)7-8-25(37)36-26/h4,6,9-12,14-15,21H,3,5,7-8,13,33H2,1-2H3,(H,35,38)(H,34,36,37)/t21-/m1/s1 GXEGTVQATHKFDH-OAQYLSRUSA-N 50339608 3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide::CHEMBL1688861 Serine/threonine-protein kinase B-raf Homo sapiens 56 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339608&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 50992247 125089710 CHEMBL1688861 ZINC66128696 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453411 Cl.Cl.NC1(CCC1)c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C30H29F3N4O3.2ClH/c31-30(32,33)21-13-19(12-20(16-21)29(34)9-1-10-29)28(39)36-22-4-2-17-3-5-23(15-18(17)14-22)40-25-8-11-35-27-24(25)6-7-26(38)37-27;;/h3,5,8,11-13,15-16,22H,1-2,4,6-7,9-10,14,34H2,(H,36,39)(H,35,37,38);2*1H/t22-;;/m1../s1 QWYNJGPOKODWOW-GJICFQLNSA-N 50139149 CHEMBL3765012 Serine/threonine-protein kinase B-raf Homo sapiens 67 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139149&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127038886 336952230 CHEMBL3765012 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453412 Cl.N[C@H](CO)c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C28H27F3N4O4.ClH/c29-28(30,31)19-10-17(23(32)14-36)9-18(11-19)27(38)34-20-3-1-15-2-4-21(13-16(15)12-20)39-24-7-8-33-26-22(24)5-6-25(37)35-26;/h2,4,7-11,13,20,23,36H,1,3,5-6,12,14,32H2,(H,34,38)(H,33,35,37);1H/t20-,23-;/m1./s1 HPOLRKQDHHIYBD-KFWGXXPESA-N 50139150 CHEMBL3763999 Serine/threonine-protein kinase B-raf Homo sapiens 207 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139150&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039874 336952231 CHEMBL3763999 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453413 Cl.Cl.OC1(CNC1)c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H27F3N4O4.2ClH/c30-29(31,32)20-10-18(9-19(13-20)28(39)14-33-15-28)27(38)35-21-3-1-16-2-4-22(12-17(16)11-21)40-24-7-8-34-26-23(24)5-6-25(37)36-26;;/h2,4,7-10,12-13,21,33,39H,1,3,5-6,11,14-15H2,(H,35,38)(H,34,36,37);2*1H/t21-;;/m1../s1 ZLLIDYXIKGEGQI-GHVWMZMZSA-N 50139151 CHEMBL3764870 Serine/threonine-protein kinase B-raf Homo sapiens 854 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139151&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039875 336952232 CHEMBL3764870 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453414 OCC1COCCN1Cc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C32H33F3N4O5/c33-32(34,35)23-12-19(16-39-9-10-43-18-25(39)17-40)11-22(13-23)31(42)37-24-3-1-20-2-4-26(15-21(20)14-24)44-28-7-8-36-30-27(28)5-6-29(41)38-30/h2,4,7-8,11-13,15,24-25,40H,1,3,5-6,9-10,14,16-18H2,(H,37,42)(H,36,38,41)/t24-,25?/m1/s1 PVXTZQASVQOJKV-IKOFQBKESA-N 50139152 CHEMBL3764275 Serine/threonine-protein kinase B-raf Homo sapiens 254 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139152&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127038548 336952233 CHEMBL3764275 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453415 FC(F)(F)c1cc(cc(c1)-c1cnc[nH]1)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H24F3N5O3/c30-29(31,32)20-10-18(24-14-33-15-35-24)9-19(11-20)28(39)36-21-3-1-16-2-4-22(13-17(16)12-21)40-25-7-8-34-27-23(25)5-6-26(38)37-27/h2,4,7-11,13-15,21H,1,3,5-6,12H2,(H,33,35)(H,36,39)(H,34,37,38)/t21-/m1/s1 AZGJHEXVDFPTCF-OAQYLSRUSA-N 50139153 CHEMBL3765355 Serine/threonine-protein kinase B-raf Homo sapiens 38 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139153&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039876 336952234 CHEMBL3765355 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453416 FC(F)(F)c1cc(cc(c1)-c1cc[nH]n1)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H24F3N5O3/c30-29(31,32)20-12-18(24-7-10-34-37-24)11-19(13-20)28(39)35-21-3-1-16-2-4-22(15-17(16)14-21)40-25-8-9-33-27-23(25)5-6-26(38)36-27/h2,4,7-13,15,21H,1,3,5-6,14H2,(H,34,37)(H,35,39)(H,33,36,38)/t21-/m1/s1 QPMHNEWPHATGSK-OAQYLSRUSA-N 50139154 CHEMBL3765074 Serine/threonine-protein kinase B-raf Homo sapiens 121 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139154&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127041188 336952235 CHEMBL3765074 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453417 Cl.FC(F)(F)c1cc(cc(c1)-c1cn[nH]c1)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H24F3N5O3.ClH/c30-29(31,32)21-10-17(20-14-34-35-15-20)9-19(11-21)28(39)36-22-3-1-16-2-4-23(13-18(16)12-22)40-25-7-8-33-27-24(25)5-6-26(38)37-27;/h2,4,7-11,13-15,22H,1,3,5-6,12H2,(H,34,35)(H,36,39)(H,33,37,38);1H/t22-;/m1./s1 LUWQBNYXTXXQTG-VZYDHVRKSA-N 50139155 CHEMBL3765708 Serine/threonine-protein kinase B-raf Homo sapiens 55 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139155&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039247 336952236 CHEMBL3765708 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453418 Cl.Cl.Cn1cnc(c1)-c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C30H26F3N5O3.2ClH/c1-38-15-25(35-16-38)19-10-20(12-21(11-19)30(31,32)33)29(40)36-22-4-2-17-3-5-23(14-18(17)13-22)41-26-8-9-34-28-24(26)6-7-27(39)37-28;;/h3,5,8-12,14-16,22H,2,4,6-7,13H2,1H3,(H,36,40)(H,34,37,39);2*1H/t22-;;/m1../s1 JNPDPRNGEUSPRB-GJICFQLNSA-N 50139156 CHEMBL3763694 Serine/threonine-protein kinase B-raf Homo sapiens 123 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139156&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039248 336952237 CHEMBL3763694 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453419 Cl.Cn1nccc1-c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C30H26F3N5O3.ClH/c1-38-25(8-11-35-38)19-12-20(14-21(13-19)30(31,32)33)29(40)36-22-4-2-17-3-5-23(16-18(17)15-22)41-26-9-10-34-28-24(26)6-7-27(39)37-28;/h3,5,8-14,16,22H,2,4,6-7,15H2,1H3,(H,36,40)(H,34,37,39);1H/t22-;/m1./s1 QCOWBGMSPURULY-VZYDHVRKSA-N 50139157 CHEMBL3764588 Serine/threonine-protein kinase B-raf Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139157&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039249 336952238 CHEMBL3764588 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453420 Cl.Cn1cc(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C30H26F3N5O3.ClH/c1-38-16-21(15-35-38)18-10-20(12-22(11-18)30(31,32)33)29(40)36-23-4-2-17-3-5-24(14-19(17)13-23)41-26-8-9-34-28-25(26)6-7-27(39)37-28;/h3,5,8-12,14-16,23H,2,4,6-7,13H2,1H3,(H,36,40)(H,34,37,39);1H/t23-;/m1./s1 BTMLMFGWUXYUEE-GNAFDRTKSA-N 50139158 CHEMBL3763646 Serine/threonine-protein kinase B-raf Homo sapiens 34 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139158&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127039250 336952239 CHEMBL3763646 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50457802 COc1c(NC(=O)Nc2ccc(-c3ccc(CN4CCOCC4)nc3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C InChI=1S/C33H39N5O5S/c1-33(2,3)23-18-29(31(42-4)30(19-23)37-44(5,40)41)36-32(39)35-28-13-12-25(26-8-6-7-9-27(26)28)22-10-11-24(34-20-22)21-38-14-16-43-17-15-38/h6-13,18-20,37H,14-17,21H2,1-5H3,(H2,35,36,39) KLPFPTSVYVEKOL-UHFFFAOYSA-N 50277623 CHEMBL451523::N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinomethyl)pyridin-3-yl)naphthalen-1-yl)ureido)phenyl)methanesulfonamide::N-{5-tert-butyl-2-methoxy-3-[({4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl}carbamoyl)amino]phenyl}methanesulfonamide Serine/threonine-protein kinase B-raf Homo sapiens 7200 ChEMBL 10.1016/j.bmcl.2009.03.104 10.7270/Q22N525R 19356929 Cirillo, PF; Hickey, ER; Moss, N; Breitfelder, S; Betageri, R; Fadra, T; Gaenzler, F; Gilmore, T; Goldberg, DR; Kamhi, V; Kirrane, T; Kroe, RR; Madwed, J; Moriak, M; Netherton, M; Pargellis, CA; Patel, UR; Qian, KC; Sharma, R; Sun, S; Swinamer, A; Torcellini, C; Takahashi, H; Tsang, M; Xiong, Z Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277623&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search B10 3GI3 9917045 104120159 CHEMBL451523 ZINC39274991 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453683 CN(C)Cc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H29F3N4O3/c1-36(2)16-17-11-20(13-21(12-17)29(30,31)32)28(38)34-22-5-3-18-4-6-23(15-19(18)14-22)39-25-9-10-33-27-24(25)7-8-26(37)35-27/h4,6,9-13,15,22H,3,5,7-8,14,16H2,1-2H3,(H,34,38)(H,33,35,37)/t22-/m1/s1 DZUFTTMDQLYMBE-JOCHJYFZSA-N 50339609 3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide::CHEMBL1688860 Serine/threonine-protein kinase B-raf Homo sapiens 2.7 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339609&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 50990961 125089711 CHEMBL1688860 ZINC66128693 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453684 FC(F)(F)c1cccc(c1)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C26H22F3N3O3/c27-26(28,29)18-3-1-2-16(12-18)25(34)31-19-6-4-15-5-7-20(14-17(15)13-19)35-22-10-11-30-24-21(22)8-9-23(33)32-24/h1-3,5,7,10-12,14,19H,4,6,8-9,13H2,(H,31,34)(H,30,32,33)/t19-/m1/s1 VWDIIVROCTXOMH-LJQANCHMSA-N 50139159 CHEMBL3765596 Serine/threonine-protein kinase B-raf Homo sapiens 3.1 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139159&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127042768 336952240 CHEMBL3765596 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453685 CNCc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C28H27F3N4O3/c1-32-15-16-10-19(12-20(11-16)28(29,30)31)27(37)34-21-4-2-17-3-5-22(14-18(17)13-21)38-24-8-9-33-26-23(24)6-7-25(36)35-26/h3,5,8-12,14,21,32H,2,4,6-7,13,15H2,1H3,(H,34,37)(H,33,35,36)/t21-/m1/s1 CHOXZXLXXUVMGG-OAQYLSRUSA-N 50339621 3-[(methylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide::CHEMBL1688876 Serine/threonine-protein kinase B-raf Homo sapiens 2.2 ChEMBL 10.1016/j.bmcl.2016.01.049 10.7270/Q29P33HD 26804230 Huang, SC; Adhikari, S; Afroze, R; Brewer, K; Calderwood, EF; Chouitar, J; England, DB; Fisher, C; Galvin, KM; Gaulin, J; Greenspan, PD; Harrison, SJ; Kim, MS; Langston, SP; Ma, LT; Menon, S; Mizutani, H; Rezaei, M; Smith, MD; Zhang, DM; Gould, AE Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339621&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 51355461 125089723 CHEMBL1688876 ZINC66112621 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453708 C[C@H](NC(=O)c1[nH]nc2cc(NCc3cccc(NC(=O)c4cc(cc(c4)C(F)(F)F)-n4cncc4C)c3)ccc12)C(N)=O InChI=1S/C30H27F3N8O3/c1-16-13-35-15-41(16)23-10-19(9-20(11-23)30(31,32)33)28(43)38-22-5-3-4-18(8-22)14-36-21-6-7-24-25(12-21)39-40-26(24)29(44)37-17(2)27(34)42/h3-13,15,17,36H,14H2,1-2H3,(H2,34,42)(H,37,44)(H,38,43)(H,39,40)/t17-/m0/s1 KCKJDURDBLOYPJ-KRWDZBQOSA-N 50145175 CHEMBL3764798 Serine/threonine-protein kinase B-raf Homo sapiens 9450 ChEMBL 10.1016/j.bmcl.2016.01.037 10.7270/Q2251M2P 26810260 Aman, W; Lee, J; Kim, M; Yang, S; Jung, H; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145175&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44317656 85426123 CHEMBL3764798 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50453713 C[C@H](NC(=O)c1[nH]nc2cc(NCc3cccc(NC(=O)c4cc(cc(c4)C(F)(F)F)-n4cncc4C)c3)ccc12)C(N)=O InChI=1S/C30H27F3N8O3/c1-16-13-35-15-41(16)23-10-19(9-20(11-23)30(31,32)33)28(43)38-22-5-3-4-18(8-22)14-36-21-6-7-24-25(12-21)39-40-26(24)29(44)37-17(2)27(34)42/h3-13,15,17,36H,14H2,1-2H3,(H2,34,42)(H,37,44)(H,38,43)(H,39,40)/t17-/m0/s1 KCKJDURDBLOYPJ-KRWDZBQOSA-N 50145175 CHEMBL3764798 Serine/threonine-protein kinase B-raf Homo sapiens 7820 ChEMBL 10.1016/j.bmcl.2016.01.037 10.7270/Q2251M2P 26810260 Aman, W; Lee, J; Kim, M; Yang, S; Jung, H; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145175&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44317656 85426123 CHEMBL3764798 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50455997 COc1cc2c3c(n[nH]c3ncc2cc1-c1c(F)ccc(NS(=O)(=O)CCCF)c1Cl)C1CC1 InChI=1S/C23H21ClF2N4O3S/c1-33-18-10-14-13(11-27-23-20(14)22(28-29-23)12-3-4-12)9-15(18)19-16(26)5-6-17(21(19)24)30-34(31,32)8-2-7-25/h5-6,9-12,30H,2-4,7-8H2,1H3,(H,27,28,29) JSKJFDXTKYWPAH-UHFFFAOYSA-N 50140046 CHEMBL3751896 Serine/threonine-protein kinase B-raf Homo sapiens 7 ChEMBL 10.1016/j.bmcl.2015.12.086 10.7270/Q2W097S9 26739779 Lu, B; Cao, H; Cao, J; Huang, S; Hu, Q; Liu, D; Shen, R; Shen, X; Tao, W; Wan, H; Wang, D; Yan, Y; Yang, L; Zhang, J; Zhang, L; Zhang, L; Zhang, M Shanghai Hengrui Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140046&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73427153 336952404 CHEMBL3751896 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50455998 CCCS(=O)(=O)Nc1ccc(F)c(c1Cl)-c1cc2cnc3[nH]nc(C4CC4)c3c2cc1OC InChI=1S/C23H22ClFN4O3S/c1-3-8-33(30,31)29-17-7-6-16(25)19(21(17)24)15-9-13-11-26-23-20(14(13)10-18(15)32-2)22(27-28-23)12-4-5-12/h6-7,9-12,29H,3-5,8H2,1-2H3,(H,26,27,28) TXGZNFUKEFASJI-UHFFFAOYSA-N 50140051 CHEMBL3753972 Serine/threonine-protein kinase B-raf Homo sapiens 80 ChEMBL 10.1016/j.bmcl.2015.12.086 10.7270/Q2W097S9 26739779 Lu, B; Cao, H; Cao, J; Huang, S; Hu, Q; Liu, D; Shen, R; Shen, X; Tao, W; Wan, H; Wang, D; Yan, Y; Yang, L; Zhang, J; Zhang, L; Zhang, L; Zhang, M Shanghai Hengrui Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140051&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73427152 336952406 CHEMBL3753972 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50455999 CCCS(=O)(=O)Nc1ccc(F)c(c1F)-c1cc2cnc3[nH]nc(C4CC4)c3c2cc1OC InChI=1S/C23H22F2N4O3S/c1-3-8-33(30,31)29-17-7-6-16(24)19(21(17)25)15-9-13-11-26-23-20(14(13)10-18(15)32-2)22(27-28-23)12-4-5-12/h6-7,9-12,29H,3-5,8H2,1-2H3,(H,26,27,28) DBMZTIOYELPZGQ-UHFFFAOYSA-N 50140052 CHEMBL3753129 Serine/threonine-protein kinase B-raf Homo sapiens 220 ChEMBL 10.1016/j.bmcl.2015.12.086 10.7270/Q2W097S9 26739779 Lu, B; Cao, H; Cao, J; Huang, S; Hu, Q; Liu, D; Shen, R; Shen, X; Tao, W; Wan, H; Wang, D; Yan, Y; Yang, L; Zhang, J; Zhang, L; Zhang, L; Zhang, M Shanghai Hengrui Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140052&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73427150 104029802 CHEMBL3753129 ZINC28225580 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50456000 CCCS(=O)(=O)Nc1ccc(F)c(c1Cl)-c1cc2cnc3[nH]ncc3c2cc1OC InChI=1S/C20H18ClFN4O3S/c1-3-6-30(27,28)26-16-5-4-15(22)18(19(16)21)13-7-11-9-23-20-14(10-24-25-20)12(11)8-17(13)29-2/h4-5,7-10,26H,3,6H2,1-2H3,(H,23,24,25) ZDADYCWPYSFPHC-UHFFFAOYSA-N 50140047 CHEMBL3752457 Serine/threonine-protein kinase B-raf Homo sapiens 11 ChEMBL 10.1016/j.bmcl.2015.12.086 10.7270/Q2W097S9 26739779 Lu, B; Cao, H; Cao, J; Huang, S; Hu, Q; Liu, D; Shen, R; Shen, X; Tao, W; Wan, H; Wang, D; Yan, Y; Yang, L; Zhang, J; Zhang, L; Zhang, L; Zhang, M Shanghai Hengrui Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140047&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73427050 104029799 CHEMBL3752457 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50456001 COc1cc2c3cn[nH]c3ncc2cc1-c1c(F)ccc(NS(=O)(=O)CCCF)c1Cl InChI=1S/C20H17ClF2N4O3S/c1-30-17-8-12-11(9-24-20-14(12)10-25-26-20)7-13(17)18-15(23)3-4-16(19(18)21)27-31(28,29)6-2-5-22/h3-4,7-10,27H,2,5-6H2,1H3,(H,24,25,26) QHKLWEMOPLBBPP-UHFFFAOYSA-N 50140048 CHEMBL3752478 Serine/threonine-protein kinase B-raf Homo sapiens 7 ChEMBL 10.1016/j.bmcl.2015.12.086 10.7270/Q2W097S9 26739779 Lu, B; Cao, H; Cao, J; Huang, S; Hu, Q; Liu, D; Shen, R; Shen, X; Tao, W; Wan, H; Wang, D; Yan, Y; Yang, L; Zhang, J; Zhang, L; Zhang, L; Zhang, M Shanghai Hengrui Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140048&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 73427151 104029800 CHEMBL3752478 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50456002 CCCS(=O)(=O)Nc1ccc(Cl)c(c1Cl)-c1cc2cnc3[nH]ncc3c2cc1OC InChI=1S/C20H18Cl2N4O3S/c1-3-6-30(27,28)26-16-5-4-15(21)18(19(16)22)13-7-11-9-23-20-14(10-24-25-20)12(11)8-17(13)29-2/h4-5,7-10,26H,3,6H2,1-2H3,(H,23,24,25) JVPXMJPJDKPDCX-UHFFFAOYSA-N 50140049 CHEMBL3751892 Serine/threonine-protein kinase B-raf Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2015.12.086 10.7270/Q2W097S9 26739779 Lu, B; Cao, H; Cao, J; Huang, S; Hu, Q; Liu, D; Shen, R; Shen, X; Tao, W; Wan, H; Wang, D; Yan, Y; Yang, L; Zhang, J; Zhang, L; Zhang, L; Zhang, M Shanghai Hengrui Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140049&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127028929 104029801 CHEMBL3751892 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50456003 CCCCS(=O)(=O)Nc1ccc(F)c(c1Cl)-c1cc2cnc3[nH]nc(C4CC4)c3c2cc1OC InChI=1S/C24H24ClFN4O3S/c1-3-4-9-34(31,32)30-18-8-7-17(26)20(22(18)25)16-10-14-12-27-24-21(15(14)11-19(16)33-2)23(28-29-24)13-5-6-13/h7-8,10-13,30H,3-6,9H2,1-2H3,(H,27,28,29) AZUXEHZHKJOAQC-UHFFFAOYSA-N 50140050 CHEMBL3753363 Serine/threonine-protein kinase B-raf Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2015.12.086 10.7270/Q2W097S9 26739779 Lu, B; Cao, H; Cao, J; Huang, S; Hu, Q; Liu, D; Shen, R; Shen, X; Tao, W; Wan, H; Wang, D; Yan, Y; Yang, L; Zhang, J; Zhang, L; Zhang, L; Zhang, M Shanghai Hengrui Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140050&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127026051 336952405 CHEMBL3753363 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50456016 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) YZDJQTHVDDOVHR-UHFFFAOYSA-N 25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720 Serine/threonine-protein kinase B-raf Homo sapiens 220 ChEMBL 10.1016/j.bmcl.2015.12.086 10.7270/Q2W097S9 26739779 Lu, B; Cao, H; Cao, J; Huang, S; Hu, Q; Liu, D; Shen, R; Shen, X; Tao, W; Wan, H; Wang, D; Yan, Y; Yang, L; Zhang, J; Zhang, L; Zhang, L; Zhang, M Shanghai Hengrui Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25617&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 324 3C4C,4WO5 24180719 56412907 DB06999 5703 ZINC39059267 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50467227 FC(F)(F)c1cc(ccc1Cl)C(=O)Nc1cccc(c1)-c1cnc2c(NC(=O)c3cc(Cl)cc(Cl)c3)nccn12 InChI=1S/C27H15Cl3F3N5O2/c28-17-8-16(9-18(29)12-17)26(40)37-23-24-35-13-22(38(24)7-6-34-23)14-2-1-3-19(10-14)36-25(39)15-4-5-21(30)20(11-15)27(31,32)33/h1-13H,(H,36,39)(H,34,37,40) ZZSMAQLIEZGUAP-UHFFFAOYSA-N 50146587 CHEMBL3764571 Serine/threonine-protein kinase B-raf Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2015.12.001 10.7270/Q2Z60QX5 26724730 Garamvölgyi, R; Dobos, J; Sipos, A; Boros, S; Illyés, E; Baska, F; Kékesi, L; Szabadkai, I; Szántai-Kis, C; Kéri, G; Orfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50146587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50146587&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9925446 104035176 CHEMBL3764571 ZINC13560989 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50467228 Fc1ccc(NC(=O)Nc2cccc(c2)-c2cnc3c(NC(=O)c4cc(Cl)cc(Cl)c4)nccn23)c(F)c1 InChI=1S/C26H16Cl2F2N6O2/c27-16-8-15(9-17(28)11-16)25(37)35-23-24-32-13-22(36(24)7-6-31-23)14-2-1-3-19(10-14)33-26(38)34-21-5-4-18(29)12-20(21)30/h1-13H,(H,31,35,37)(H2,33,34,38) JTLWTLJMIQDBQM-UHFFFAOYSA-N 50146588 CHEMBL3764145 Serine/threonine-protein kinase B-raf Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2015.12.001 10.7270/Q2Z60QX5 26724730 Garamvölgyi, R; Dobos, J; Sipos, A; Boros, S; Illyés, E; Baska, F; Kékesi, L; Szabadkai, I; Szántai-Kis, C; Kéri, G; Orfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50146588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50146588&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10411726 104035177 CHEMBL3764145 ZINC03948439 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50467229 FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)-c2cnc3c(NC(=O)c4cc(Cl)cc(Cl)c4)nccn23)ccc1Cl InChI=1S/C27H16Cl3F3N6O2/c28-16-8-15(9-17(29)11-16)25(40)38-23-24-35-13-22(39(24)7-6-34-23)14-2-1-3-18(10-14)36-26(41)37-19-4-5-21(30)20(12-19)27(31,32)33/h1-13H,(H,34,38,40)(H2,36,37,41) FKJSPJLILXPUJZ-UHFFFAOYSA-N 50146589 CHEMBL3765683 Serine/threonine-protein kinase B-raf Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2015.12.001 10.7270/Q2Z60QX5 26724730 Garamvölgyi, R; Dobos, J; Sipos, A; Boros, S; Illyés, E; Baska, F; Kékesi, L; Szabadkai, I; Szántai-Kis, C; Kéri, G; Orfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50146589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50146589&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10158779 104035178 CHEMBL3765683 ZINC12365506 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50467230 FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1nccn2c(cnc12)-c1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1 InChI=1S/C29H16ClF9N6O2/c30-21-5-4-19(12-20(21)29(37,38)39)43-26(47)42-18-3-1-2-14(10-18)22-13-41-24-23(40-6-7-45(22)24)44-25(46)15-8-16(27(31,32)33)11-17(9-15)28(34,35)36/h1-13H,(H,40,44,46)(H2,42,43,47) SOJZMBOWRWJKBH-UHFFFAOYSA-N 50146590 CHEMBL3765068 Serine/threonine-protein kinase B-raf Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2015.12.001 10.7270/Q2Z60QX5 26724730 Garamvölgyi, R; Dobos, J; Sipos, A; Boros, S; Illyés, E; Baska, F; Kékesi, L; Szabadkai, I; Szántai-Kis, C; Kéri, G; Orfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50146590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50146590&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10430909 104035179 CHEMBL3765068 ZINC03947630 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50467231 Fc1ccc(cc1C(F)(F)F)C(=O)Nc1nccn2c(cnc12)-c1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1 InChI=1S/C28H16ClF7N6O2/c29-20-6-5-17(12-18(20)27(31,32)33)40-26(44)39-16-3-1-2-14(10-16)22-13-38-24-23(37-8-9-42(22)24)41-25(43)15-4-7-21(30)19(11-15)28(34,35)36/h1-13H,(H,37,41,43)(H2,39,40,44) IRLSPFFMFJRFCW-UHFFFAOYSA-N 50146591 CHEMBL3763692 Serine/threonine-protein kinase B-raf Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2015.12.001 10.7270/Q2Z60QX5 26724730 Garamvölgyi, R; Dobos, J; Sipos, A; Boros, S; Illyés, E; Baska, F; Kékesi, L; Szabadkai, I; Szántai-Kis, C; Kéri, G; Orfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50146591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50146591&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9903069 104035180 CHEMBL3763692 ZINC13560995 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50467232 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 1140 ChEMBL 10.1016/j.ejmech.2015.12.001 10.7270/Q2Z60QX5 26724730 Garamvölgyi, R; Dobos, J; Sipos, A; Boros, S; Illyés, E; Baska, F; Kékesi, L; Szabadkai, I; Szántai-Kis, C; Kéri, G; Orfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50467233 FC(F)(F)c1cc(ccc1Cl)C(=O)Nc1cccc(c1)-c1cnc2c(NC(=O)c3cc(Cl)cc(Cl)c3)nccn12 InChI=1S/C27H15Cl3F3N5O2/c28-17-8-16(9-18(29)12-17)26(40)37-23-24-35-13-22(38(24)7-6-34-23)14-2-1-3-19(10-14)36-25(39)15-4-5-21(30)20(11-15)27(31,32)33/h1-13H,(H,36,39)(H,34,37,40) ZZSMAQLIEZGUAP-UHFFFAOYSA-N 50146587 CHEMBL3764571 Serine/threonine-protein kinase B-raf Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2015.12.001 10.7270/Q2Z60QX5 26724730 Garamvölgyi, R; Dobos, J; Sipos, A; Boros, S; Illyés, E; Baska, F; Kékesi, L; Szabadkai, I; Szántai-Kis, C; Kéri, G; Orfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50146587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50146587&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9925446 104035176 CHEMBL3764571 ZINC13560989 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50467234 Fc1ccc(NC(=O)Nc2cccc(c2)-c2cnc3c(NC(=O)c4cc(Cl)cc(Cl)c4)nccn23)c(F)c1 InChI=1S/C26H16Cl2F2N6O2/c27-16-8-15(9-17(28)11-16)25(37)35-23-24-32-13-22(36(24)7-6-31-23)14-2-1-3-19(10-14)33-26(38)34-21-5-4-18(29)12-20(21)30/h1-13H,(H,31,35,37)(H2,33,34,38) JTLWTLJMIQDBQM-UHFFFAOYSA-N 50146588 CHEMBL3764145 Serine/threonine-protein kinase B-raf Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2015.12.001 10.7270/Q2Z60QX5 26724730 Garamvölgyi, R; Dobos, J; Sipos, A; Boros, S; Illyés, E; Baska, F; Kékesi, L; Szabadkai, I; Szántai-Kis, C; Kéri, G; Orfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50146588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50146588&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10411726 104035177 CHEMBL3764145 ZINC03948439 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50467235 FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)-c2cnc3c(NC(=O)c4cc(Cl)cc(Cl)c4)nccn23)ccc1Cl InChI=1S/C27H16Cl3F3N6O2/c28-16-8-15(9-17(29)11-16)25(40)38-23-24-35-13-22(39(24)7-6-34-23)14-2-1-3-18(10-14)36-26(41)37-19-4-5-21(30)20(12-19)27(31,32)33/h1-13H,(H,34,38,40)(H2,36,37,41) FKJSPJLILXPUJZ-UHFFFAOYSA-N 50146589 CHEMBL3765683 Serine/threonine-protein kinase B-raf Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2015.12.001 10.7270/Q2Z60QX5 26724730 Garamvölgyi, R; Dobos, J; Sipos, A; Boros, S; Illyés, E; Baska, F; Kékesi, L; Szabadkai, I; Szántai-Kis, C; Kéri, G; Orfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50146589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50146589&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10158779 104035178 CHEMBL3765683 ZINC12365506 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50467236 FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1nccn2c(cnc12)-c1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1 InChI=1S/C29H16ClF9N6O2/c30-21-5-4-19(12-20(21)29(37,38)39)43-26(47)42-18-3-1-2-14(10-18)22-13-41-24-23(40-6-7-45(22)24)44-25(46)15-8-16(27(31,32)33)11-17(9-15)28(34,35)36/h1-13H,(H,40,44,46)(H2,42,43,47) SOJZMBOWRWJKBH-UHFFFAOYSA-N 50146590 CHEMBL3765068 Serine/threonine-protein kinase B-raf Homo sapiens >12500 ChEMBL 10.1016/j.ejmech.2015.12.001 10.7270/Q2Z60QX5 26724730 Garamvölgyi, R; Dobos, J; Sipos, A; Boros, S; Illyés, E; Baska, F; Kékesi, L; Szabadkai, I; Szántai-Kis, C; Kéri, G; Orfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50146590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50146590&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10430909 104035179 CHEMBL3765068 ZINC03947630 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50467237 Fc1ccc(cc1C(F)(F)F)C(=O)Nc1nccn2c(cnc12)-c1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1 InChI=1S/C28H16ClF7N6O2/c29-20-6-5-17(12-18(20)27(31,32)33)40-26(44)39-16-3-1-2-14(10-16)22-13-38-24-23(37-8-9-42(22)24)41-25(43)15-4-7-21(30)19(11-15)28(34,35)36/h1-13H,(H,37,41,43)(H2,39,40,44) IRLSPFFMFJRFCW-UHFFFAOYSA-N 50146591 CHEMBL3763692 Serine/threonine-protein kinase B-raf Homo sapiens 5010 ChEMBL 10.1016/j.ejmech.2015.12.001 10.7270/Q2Z60QX5 26724730 Garamvölgyi, R; Dobos, J; Sipos, A; Boros, S; Illyés, E; Baska, F; Kékesi, L; Szabadkai, I; Szántai-Kis, C; Kéri, G; Orfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50146591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50146591&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9903069 104035180 CHEMBL3763692 ZINC13560995 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50467238 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 280 ChEMBL 10.1016/j.ejmech.2015.12.001 10.7270/Q2Z60QX5 26724730 Garamvölgyi, R; Dobos, J; Sipos, A; Boros, S; Illyés, E; Baska, F; Kékesi, L; Szabadkai, I; Szántai-Kis, C; Kéri, G; Orfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50497696 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 31 ChEMBL 10.1021/acs.jnatprod.5b01055 10.7270/Q2W37Z73 26852623 Newman, DJ; Cragg, GM NIH Special Volunteer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50497697 N(c1c[nH]c2ncccc12)c1ccccc1 InChI=1S/C13H11N3/c1-2-5-10(6-3-1)16-12-9-15-13-11(12)7-4-8-14-13/h1-9,16H,(H,14,15) CQFGXDQUQWRXLE-UHFFFAOYSA-N 50172099 CHEMBL1231605 Serine/threonine-protein kinase B-raf Homo sapiens >100000 ChEMBL 10.1021/acs.jnatprod.5b01055 10.7270/Q2W37Z73 26852623 Newman, DJ; Cragg, GM NIH Special Volunteer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50172099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50172099&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search C4E 3C4E 24180721 346548606 CHEMBL1231605 DB07524 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494516 Fc1ccc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2C#N)cc1NC(=O)Cc1cccc(c1)C(F)(F)F InChI=1S/C27H18F4N4O3S/c28-19-7-6-17(12-21(19)33-23(36)11-14-2-1-3-16(10-14)27(29,30)31)38-22-9-8-20-24(18(22)13-32)39-26(34-20)35-25(37)15-4-5-15/h1-3,6-10,12,15H,4-5,11H2,(H,33,36)(H,34,35,37) OJFKUJDRGJSAQB-UHFFFAOYSA-N 99471 US8497274, 32 Serine/threonine-protein kinase B-raf Homo sapiens 77 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=99471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=99471&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 1SU 6OC1,4KSP 46209401 164040715 ZINC68208189 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494517 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 119 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494518 CC(=O)Nc1cc(Nc2cccc(NC(=O)c3cccc(c3)C3CC3)c2)ccn1 InChI=1S/C23H22N4O2/c1-15(28)25-22-14-21(10-11-24-22)26-19-6-3-7-20(13-19)27-23(29)18-5-2-4-17(12-18)16-8-9-16/h2-7,10-14,16H,8-9H2,1H3,(H,27,29)(H2,24,25,26,28) SXKIBVXCNLXFDA-UHFFFAOYSA-N 50167875 CHEMBL3799934 Serine/threonine-protein kinase B-raf Homo sapiens 1200 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167875&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047786 341098084 CHEMBL3799934 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494519 O=C(Nc1cc(Nc2cccc(NC(=O)c3cccc(c3)C3(CC3)C#N)c2)ccn1)C1CC1 InChI=1S/C26H23N5O2/c27-16-26(10-11-26)19-4-1-3-18(13-19)25(33)30-21-6-2-5-20(14-21)29-22-9-12-28-23(15-22)31-24(32)17-7-8-17/h1-6,9,12-15,17H,7-8,10-11H2,(H,30,33)(H2,28,29,31,32) SHADBITUPIDTHH-UHFFFAOYSA-N 50167876 CHEMBL3800220 Serine/threonine-protein kinase B-raf Homo sapiens 2031 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167876&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046461 104053081 CHEMBL3800220 ZINC28476859 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494520 CC(C)(C#N)c1cccc(c1)C(=O)Nc1cccc(Nc2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C26H25N5O2/c1-26(2,16-27)19-6-3-5-18(13-19)25(33)30-21-8-4-7-20(14-21)29-22-11-12-28-23(15-22)31-24(32)17-9-10-17/h3-8,11-15,17H,9-10H2,1-2H3,(H,30,33)(H2,28,29,31,32) JWVFWAOUTZYRSM-UHFFFAOYSA-N 50167877 CHEMBL3798081 Serine/threonine-protein kinase B-raf Homo sapiens 476 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167877&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046460 104053082 CHEMBL3798081 ZINC28467821 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494521 O=C(Nc1cc(Nc2cccc(NC(=O)c3cccc(c3)C3CC3)c2)ccn1)C1CC1 InChI=1S/C25H24N4O2/c30-24(17-9-10-17)29-23-15-22(11-12-26-23)27-20-5-2-6-21(14-20)28-25(31)19-4-1-3-18(13-19)16-7-8-16/h1-6,11-17H,7-10H2,(H,28,31)(H2,26,27,29,30) NQSVGLUQAXAPFF-UHFFFAOYSA-N 50167878 CHEMBL3798225 Serine/threonine-protein kinase B-raf Homo sapiens 453 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167878&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046459 104053083 CHEMBL3798225 ZINC40538368 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494522 CC(C)(C)c1cccc(c1)C(=O)Nc1cccc(Nc2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C26H28N4O2/c1-26(2,3)19-7-4-6-18(14-19)25(32)29-21-9-5-8-20(15-21)28-22-12-13-27-23(16-22)30-24(31)17-10-11-17/h4-9,12-17H,10-11H2,1-3H3,(H,29,32)(H2,27,28,30,31) YKVDJCJICRUOFC-UHFFFAOYSA-N 50167879 CHEMBL3797670 Serine/threonine-protein kinase B-raf Homo sapiens 240 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167879&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046458 104053084 CHEMBL3797670 ZINC28473627 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494523 CC(C)c1cccc(c1)C(=O)Nc1cccc(Nc2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C25H26N4O2/c1-16(2)18-5-3-6-19(13-18)25(31)28-21-8-4-7-20(14-21)27-22-11-12-26-23(15-22)29-24(30)17-9-10-17/h3-8,11-17H,9-10H2,1-2H3,(H,28,31)(H2,26,27,29,30) FVMZLWPHAKPWKE-UHFFFAOYSA-N 50167880 CHEMBL3800043 Serine/threonine-protein kinase B-raf Homo sapiens 148 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167880&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046457 104053085 CHEMBL3800043 ZINC28473152 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494524 Fc1ccc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2C#N)cc1NC(=O)Cc1cccc(c1)C(F)(F)F InChI=1S/C27H18F4N4O3S/c28-19-7-6-17(12-21(19)33-23(36)11-14-2-1-3-16(10-14)27(29,30)31)38-22-9-8-20-24(18(22)13-32)39-26(34-20)35-25(37)15-4-5-15/h1-3,6-10,12,15H,4-5,11H2,(H,33,36)(H,34,35,37) OJFKUJDRGJSAQB-UHFFFAOYSA-N 99471 US8497274, 32 Serine/threonine-protein kinase B-raf Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=99471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=99471&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 1SU 6OC1,4KSP 46209401 164040715 ZINC68208189 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494525 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 59 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494526 O=C(Nc1cc(Nc2cccc(NC(=O)c3cccc(c3)C3CC3)c2)ccn1)C1CCCCC1 InChI=1S/C28H30N4O2/c33-27(20-6-2-1-3-7-20)32-26-18-25(14-15-29-26)30-23-10-5-11-24(17-23)31-28(34)22-9-4-8-21(16-22)19-12-13-19/h4-5,8-11,14-20H,1-3,6-7,12-13H2,(H,31,34)(H2,29,30,32,33) VKWOAZDLUKBFTR-UHFFFAOYSA-N 50167881 CHEMBL3797591 Serine/threonine-protein kinase B-raf Homo sapiens 563 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167881&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047125 104053086 CHEMBL3797591 ZINC28470639 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494527 O=C(Nc1cc(Nc2cccc(NC(=O)c3cccc(c3)C3CC3)c2)ccn1)C1CCCC1 InChI=1S/C27H28N4O2/c32-26(19-5-1-2-6-19)31-25-17-24(13-14-28-25)29-22-9-4-10-23(16-22)30-27(33)21-8-3-7-20(15-21)18-11-12-18/h3-4,7-10,13-19H,1-2,5-6,11-12H2,(H,30,33)(H2,28,29,31,32) SKGXODAWMYHOHA-UHFFFAOYSA-N 50167882 CHEMBL3800517 Serine/threonine-protein kinase B-raf Homo sapiens 434 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167882&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047909 104053087 CHEMBL3800517 ZINC28468132 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494528 O=C(Nc1cc(Nc2cccc(NC(=O)c3cccc(c3)C3CC3)c2)ccn1)C1CCC1 InChI=1S/C26H26N4O2/c31-25(18-4-1-5-18)30-24-16-23(12-13-27-24)28-21-8-3-9-22(15-21)29-26(32)20-7-2-6-19(14-20)17-10-11-17/h2-3,6-9,12-18H,1,4-5,10-11H2,(H,29,32)(H2,27,28,30,31) CHHBQJYQDREXPZ-UHFFFAOYSA-N 50167883 CHEMBL3798661 Serine/threonine-protein kinase B-raf Homo sapiens 182 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167883&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047908 104053088 CHEMBL3798661 ZINC28473741 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494529 CC(C)(C)C(=O)Nc1cc(Nc2cccc(NC(=O)c3cccc(c3)C3CC3)c2)ccn1 InChI=1S/C26H28N4O2/c1-26(2,3)25(32)30-23-16-22(12-13-27-23)28-20-8-5-9-21(15-20)29-24(31)19-7-4-6-18(14-19)17-10-11-17/h4-9,12-17H,10-11H2,1-3H3,(H,29,31)(H2,27,28,30,32) GRIOPPDFIYVNPG-UHFFFAOYSA-N 50167884 CHEMBL3799637 Serine/threonine-protein kinase B-raf Homo sapiens 1030 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167884&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047788 341098085 CHEMBL3799637 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494530 CC(C)C(=O)Nc1cc(Nc2cccc(NC(=O)c3cccc(c3)C3CC3)c2)ccn1 InChI=1S/C25H26N4O2/c1-16(2)24(30)29-23-15-22(11-12-26-23)27-20-7-4-8-21(14-20)28-25(31)19-6-3-5-18(13-19)17-9-10-17/h3-8,11-17H,9-10H2,1-2H3,(H,28,31)(H2,26,27,29,30) PDNKYBOAYZVYIE-UHFFFAOYSA-N 50167885 CHEMBL3800288 Serine/threonine-protein kinase B-raf Homo sapiens 420 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167885&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046232 341098086 CHEMBL3800288 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494531 CCC(=O)Nc1cc(Nc2cccc(NC(=O)c3cccc(c3)C3CC3)c2)ccn1 InChI=1S/C24H24N4O2/c1-2-23(29)28-22-15-21(11-12-25-22)26-19-7-4-8-20(14-19)27-24(30)18-6-3-5-17(13-18)16-9-10-16/h3-8,11-16H,2,9-10H2,1H3,(H,27,30)(H2,25,26,28,29) KJUNKADRFBSOFC-UHFFFAOYSA-N 50167886 CHEMBL3797339 Serine/threonine-protein kinase B-raf Homo sapiens 125 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167886&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047787 341098087 CHEMBL3797339 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494532 CC(=O)Nc1cc(Nc2cccc(NC(=O)c3cccc(c3)C3CC3)c2)ccn1 InChI=1S/C23H22N4O2/c1-15(28)25-22-14-21(10-11-24-22)26-19-6-3-7-20(13-19)27-23(29)18-5-2-4-17(12-18)16-8-9-16/h2-7,10-14,16H,8-9H2,1H3,(H,27,29)(H2,24,25,26,28) SXKIBVXCNLXFDA-UHFFFAOYSA-N 50167875 CHEMBL3799934 Serine/threonine-protein kinase B-raf Homo sapiens 50 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167875&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047786 341098084 CHEMBL3799934 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494533 O=C(Nc1cc(Nc2cccc(NC(=O)c3cccc(c3)C3(CC3)C#N)c2)ccn1)C1CC1 InChI=1S/C26H23N5O2/c27-16-26(10-11-26)19-4-1-3-18(13-19)25(33)30-21-6-2-5-20(14-21)29-22-9-12-28-23(15-22)31-24(32)17-7-8-17/h1-6,9,12-15,17H,7-8,10-11H2,(H,30,33)(H2,28,29,31,32) SHADBITUPIDTHH-UHFFFAOYSA-N 50167876 CHEMBL3800220 Serine/threonine-protein kinase B-raf Homo sapiens 79 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167876&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046461 104053081 CHEMBL3800220 ZINC28476859 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494534 CC(C)(C#N)c1cccc(c1)C(=O)Nc1cccc(Nc2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C26H25N5O2/c1-26(2,16-27)19-6-3-5-18(13-19)25(33)30-21-8-4-7-20(14-21)29-22-11-12-28-23(15-22)31-24(32)17-9-10-17/h3-8,11-15,17H,9-10H2,1-2H3,(H,30,33)(H2,28,29,31,32) JWVFWAOUTZYRSM-UHFFFAOYSA-N 50167877 CHEMBL3798081 Serine/threonine-protein kinase B-raf Homo sapiens 38 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167877&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046460 104053082 CHEMBL3798081 ZINC28467821 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494535 O=C(Nc1cc(Nc2cccc(NC(=O)c3cccc(c3)C3CC3)c2)ccn1)C1CC1 InChI=1S/C25H24N4O2/c30-24(17-9-10-17)29-23-15-22(11-12-26-23)27-20-5-2-6-21(14-20)28-25(31)19-4-1-3-18(13-19)16-7-8-16/h1-6,11-17H,7-10H2,(H,28,31)(H2,26,27,29,30) NQSVGLUQAXAPFF-UHFFFAOYSA-N 50167878 CHEMBL3798225 Serine/threonine-protein kinase B-raf Homo sapiens 35 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167878&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046459 104053083 CHEMBL3798225 ZINC40538368 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494536 CC(C)(C)c1cccc(c1)C(=O)Nc1cccc(Nc2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C26H28N4O2/c1-26(2,3)19-7-4-6-18(14-19)25(32)29-21-9-5-8-20(15-21)28-22-12-13-27-23(16-22)30-24(31)17-10-11-17/h4-9,12-17H,10-11H2,1-3H3,(H,29,32)(H2,27,28,30,31) YKVDJCJICRUOFC-UHFFFAOYSA-N 50167879 CHEMBL3797670 Serine/threonine-protein kinase B-raf Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167879&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046458 104053084 CHEMBL3797670 ZINC28473627 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494537 CC(C)c1cccc(c1)C(=O)Nc1cccc(Nc2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C25H26N4O2/c1-16(2)18-5-3-6-19(13-18)25(31)28-21-8-4-7-20(14-21)27-22-11-12-26-23(15-22)29-24(30)17-9-10-17/h3-8,11-17H,9-10H2,1-2H3,(H,28,31)(H2,26,27,29,30) FVMZLWPHAKPWKE-UHFFFAOYSA-N 50167880 CHEMBL3800043 Serine/threonine-protein kinase B-raf Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167880&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046457 104053085 CHEMBL3800043 ZINC28473152 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494538 CCc1cccc(c1)C(=O)Nc1cccc(Nc2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C24H24N4O2/c1-2-16-5-3-6-18(13-16)24(30)27-20-8-4-7-19(14-20)26-21-11-12-25-22(15-21)28-23(29)17-9-10-17/h3-8,11-15,17H,2,9-10H2,1H3,(H,27,30)(H2,25,26,28,29) PVEWZZQGPHDGHI-UHFFFAOYSA-N 50167888 CHEMBL3798469 Serine/threonine-protein kinase B-raf Homo sapiens 110 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167888&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047632 341098088 CHEMBL3798469 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494539 Cc1cccc(c1)C(=O)Nc1cccc(Nc2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C23H22N4O2/c1-15-4-2-5-17(12-15)23(29)26-19-7-3-6-18(13-19)25-20-10-11-24-21(14-20)27-22(28)16-8-9-16/h2-7,10-14,16H,8-9H2,1H3,(H,26,29)(H2,24,25,27,28) PUEYELXDFDXVBI-UHFFFAOYSA-N 50167889 CHEMBL3800388 Serine/threonine-protein kinase B-raf Homo sapiens 1210 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167889&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047509 341098089 CHEMBL3800388 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494540 O=C(Nc1cc(Nc2cccc(NC(=O)c3cccc(c3)C#N)c2)ccn1)C1CC1 InChI=1S/C23H19N5O2/c24-14-15-3-1-4-17(11-15)23(30)27-19-6-2-5-18(12-19)26-20-9-10-25-21(13-20)28-22(29)16-7-8-16/h1-6,9-13,16H,7-8H2,(H,27,30)(H2,25,26,28,29) VLCZAESJCBRRPR-UHFFFAOYSA-N 50167893 CHEMBL3798792 Serine/threonine-protein kinase B-raf Homo sapiens 3530 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167893&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047508 341098090 CHEMBL3798792 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494541 [O-][N+](=O)c1cccc(c1)C(=O)Nc1cccc(Nc2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C22H19N5O4/c28-21(14-7-8-14)26-20-13-18(9-10-23-20)24-16-4-2-5-17(12-16)25-22(29)15-3-1-6-19(11-15)27(30)31/h1-6,9-14H,7-8H2,(H,25,29)(H2,23,24,26,28) WBZDZPAJFBUGOG-UHFFFAOYSA-N 50167894 CHEMBL3797953 Serine/threonine-protein kinase B-raf Homo sapiens 1512 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167894&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047507 341098091 CHEMBL3797953 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494542 Clc1cccc(c1)C(=O)Nc1cccc(Nc2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C22H19ClN4O2/c23-16-4-1-3-15(11-16)22(29)26-18-6-2-5-17(12-18)25-19-9-10-24-20(13-19)27-21(28)14-7-8-14/h1-6,9-14H,7-8H2,(H,26,29)(H2,24,25,27,28) YFFLRXNHRUQGET-UHFFFAOYSA-N 50167895 CHEMBL3797868 Serine/threonine-protein kinase B-raf Homo sapiens 785 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167895&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047506 341098092 CHEMBL3797868 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494543 FC(F)(F)c1ccc(cc1)C(=O)Nc1cccc(Nc2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C23H19F3N4O2/c24-23(25,26)16-8-6-15(7-9-16)21(31)29-18-3-1-2-17(12-18)28-19-10-11-27-20(13-19)30-22(32)14-4-5-14/h1-3,6-14H,4-5H2,(H,29,31)(H2,27,28,30,32) UNXFKAKUEUZZNW-UHFFFAOYSA-N 50167897 CHEMBL3798151 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167897&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047369 104053094 CHEMBL3798151 ZINC28476702 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494544 FC(F)(F)c1ccccc1C(=O)Nc1cccc(Nc2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C23H19F3N4O2/c24-23(25,26)19-7-2-1-6-18(19)22(32)29-16-5-3-4-15(12-16)28-17-10-11-27-20(13-17)30-21(31)14-8-9-14/h1-7,10-14H,8-9H2,(H,29,32)(H2,27,28,30,31) PZMXYXPIGYIEAO-UHFFFAOYSA-N 50167899 CHEMBL3799344 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167899&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047368 341098093 CHEMBL3799344 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50494545 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Nc2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C23H19F3N4O2/c24-23(25,26)16-4-1-3-15(11-16)22(32)29-18-6-2-5-17(12-18)28-19-9-10-27-20(13-19)30-21(31)14-7-8-14/h1-6,9-14H,7-8H2,(H,29,32)(H2,27,28,30,31) JFBCQCMZRYKEGS-UHFFFAOYSA-N 50167900 CHEMBL3799171 Serine/threonine-protein kinase B-raf Homo sapiens 141 ChEMBL 10.1016/j.bmcl.2016.04.076 10.7270/Q2J67JTP 27155899 Li, X; Shen, J; Tan, L; Zhang, Z; Gao, D; Luo, J; Cheng, H; Zhou, X; Ma, J; Ding, K; Lu, X Jilin University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167900&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127045839 341098094 CHEMBL3799171 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50496765 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase B-raf Homo sapiens 5.0 ChEMBL 10.1016/j.ejmech.2016.03.074 10.7270/Q2QJ7K5K 27089211 Zhan, W; Xu, L; Dong, X; Dong, J; Yi, X; Ma, X; Qiu, N; Li, J; Yang, B; Zhou, Y; Hu, Y Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50497957 COC(=O)c1cc2cc(NCc3cc(NC(=O)c4cc(cc(c4)C(F)(F)F)-n4cnc(C)c4)ccc3C)cnc2[nH]1 InChI=1S/C29H25F3N6O3/c1-16-4-5-22(8-20(16)12-33-23-7-18-10-25(28(40)41-3)37-26(18)34-13-23)36-27(39)19-6-21(29(30,31)32)11-24(9-19)38-14-17(2)35-15-38/h4-11,13-15,33H,12H2,1-3H3,(H,34,37)(H,36,39) PGQWALGGBUYLQF-UHFFFAOYSA-N 50172492 CHEMBL3808884 Serine/threonine-protein kinase B-raf Homo sapiens 10.0 ChEMBL 10.1021/acs.jmedchem.6b00087 10.7270/Q2QF8VTR 27010810 Daydé-Cazals, B; Fauvel, B; Singer, M; Feneyrolles, C; Bestgen, B; Gassiot, F; Spenlinhauer, A; Warnault, P; Van Hijfte, N; Borjini, N; Chevé, G; Yasri, A OriBase Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50172492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50172492&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 68796885 104058547 CHEMBL3808884 ZINC36177101 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493168 Cc1n[nH]c(C)c1S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C21H17F2N9O2S/c1-10-19(11(2)31-30-10)35(33,34)32-14-6-5-13(22)17(15(14)23)29-20-12(4-3-7-24-20)16-18-21(27-8-25-16)28-9-26-18/h3-9,32H,1-2H3,(H,24,29)(H,30,31)(H,25,26,27,28) GOZZYNGIYPRQOB-UHFFFAOYSA-N 50165855 CHEMBL3800378 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165855&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127045771 104051353 CHEMBL3800378 ZINC28524373 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493169 CC(C)(C)CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C21H21F2N7O2S/c1-21(2,3)9-33(31,32)30-14-7-6-13(22)17(15(14)23)29-19-12(5-4-8-24-19)16-18-20(27-10-25-16)28-11-26-18/h4-8,10-11,30H,9H2,1-3H3,(H,24,29)(H,25,26,27,28) SMQPPWBGDWYCFJ-UHFFFAOYSA-N 50165856 CHEMBL3799342 Serine/threonine-protein kinase B-raf Homo sapiens 6.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165856&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046615 104051354 CHEMBL3799342 ZINC28524535 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493170 Fc1ccc(NS(=O)(=O)Cc2ccccc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C23H17F2N7O2S/c24-16-8-9-17(32-35(33,34)11-14-5-2-1-3-6-14)18(25)20(16)31-22-15(7-4-10-26-22)19-21-23(29-12-27-19)30-13-28-21/h1-10,12-13,32H,11H2,(H,26,31)(H,27,28,29,30) KXZXQWZNHDHQET-UHFFFAOYSA-N 50165857 CHEMBL3800157 Serine/threonine-protein kinase B-raf Homo sapiens 186 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165857&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047893 104051355 CHEMBL3800157 ZINC28522120 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493171 CC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H17F2N7O2S/c1-10(2)31(29,30)28-13-6-5-12(20)16(14(13)21)27-18-11(4-3-7-22-18)15-17-19(25-8-23-15)26-9-24-17/h3-10,28H,1-2H3,(H,22,27)(H,23,24,25,26) LJGJKSMJLUENHX-UHFFFAOYSA-N 197673 US9216981, 1 Serine/threonine-protein kinase B-raf Homo sapiens 14 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344791 318488790 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493172 CCC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H19F2N7O2S/c1-3-11(2)32(30,31)29-14-7-6-13(21)17(15(14)22)28-19-12(5-4-8-23-19)16-18-20(26-9-24-16)27-10-25-18/h4-11,29H,3H2,1-2H3,(H,23,28)(H,24,25,26,27) XMFJRQPXMQXCTL-UHFFFAOYSA-N 50165858 CHEMBL3800227 Serine/threonine-protein kinase B-raf Homo sapiens 7.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165858&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048021 341097711 CHEMBL3800227 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493173 CCCC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C21H21F2N7O2S/c1-3-5-12(2)33(31,32)30-15-8-7-14(22)18(16(15)23)29-20-13(6-4-9-24-20)17-19-21(27-10-25-17)28-11-26-19/h4,6-12,30H,3,5H2,1-2H3,(H,24,29)(H,25,26,27,28) KASOTWCGKVLVEN-UHFFFAOYSA-N 50165859 CHEMBL3799288 Serine/threonine-protein kinase B-raf Homo sapiens 18 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165859&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048022 341097712 CHEMBL3799288 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493174 Fc1ccc(NS(=O)(=O)C2CC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C19H15F2N7O2S/c20-12-5-6-13(28-31(29,30)10-3-4-10)14(21)16(12)27-18-11(2-1-7-22-18)15-17-19(25-8-23-15)26-9-24-17/h1-2,5-10,28H,3-4H2,(H,22,27)(H,23,24,25,26) SMMQTLKZQUWOFV-UHFFFAOYSA-N 197690 US9216981, 19 Serine/threonine-protein kinase B-raf Homo sapiens 41 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197690&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345095 318488807 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493175 Fc1ccc(NS(=O)(=O)C2CCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H17F2N7O2S/c21-13-6-7-14(29-32(30,31)11-3-1-4-11)15(22)17(13)28-19-12(5-2-8-23-19)16-18-20(26-9-24-16)27-10-25-18/h2,5-11,29H,1,3-4H2,(H,23,28)(H,24,25,26,27) JONADRDDUBKXHN-UHFFFAOYSA-N 50165860 CHEMBL3798630 Serine/threonine-protein kinase B-raf Homo sapiens 4.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165860&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048023 341097713 CHEMBL3798630 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493176 Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C26H19ClN8/c1-15-4-9-19-18(10-12-29-24(19)34-17-7-5-16(27)6-8-17)21(15)35-25-20(3-2-11-28-25)22-23-26(32-13-30-22)33-14-31-23/h2-14H,1H3,(H,28,35)(H,29,34)(H,30,31,32,33) KKVYYGGCHJGEFJ-UHFFFAOYSA-N 50165861 CHEMBL1197798 Serine/threonine-protein kinase B-raf Homo sapiens 2.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165861&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44223999 341097714 CHEMBL1197798 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493177 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 20 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493178 CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29) BFSMGDJOXZAERB-UHFFFAOYSA-N 50428286 DABRAFENIB::GSK2118436A Serine/threonine-protein kinase B-raf Homo sapiens 0.400000 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50428286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50428286&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search P06 7RIV,4XV2,5CSW,6HJ2,6V2U,5HIE 44462760 164157161 75045 DB08912 ZINC68153186 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493179 Fc1ccc(NS(=O)(=O)c2ccccc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H15F2N7O2S/c23-15-8-9-16(31-34(32,33)13-5-2-1-3-6-13)17(24)19(15)30-21-14(7-4-10-25-21)18-20-22(28-11-26-18)29-12-27-20/h1-12,31H,(H,25,30)(H,26,27,28,29) UHPAFPKCOMSYMO-UHFFFAOYSA-N 197706 US9216981, 35::US9550781, 15 Serine/threonine-protein kinase B-raf Homo sapiens 17 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197706&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343766 318488823 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493180 Fc1ccc(NS(=O)(=O)c2ccccc2F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H14F3N7O2S/c23-13-5-1-2-6-16(13)35(33,34)32-15-8-7-14(24)19(17(15)25)31-21-12(4-3-9-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) ILBNLHRNSBVYOE-UHFFFAOYSA-N 50165863 CHEMBL3800226 Serine/threonine-protein kinase B-raf Homo sapiens 10.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165863&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047050 341097715 CHEMBL3800226 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493181 Fc1cccc(c1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H14F3N7O2S/c23-12-3-1-4-13(9-12)35(33,34)32-16-7-6-15(24)19(17(16)25)31-21-14(5-2-8-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) NAMHUPSTGXJBQO-UHFFFAOYSA-N 50165864 CHEMBL3799014 Serine/threonine-protein kinase B-raf Homo sapiens 4.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165864&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047051 341097716 CHEMBL3799014 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493182 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H14F3N7O2S/c23-12-3-5-13(6-4-12)35(33,34)32-16-8-7-15(24)19(17(16)25)31-21-14(2-1-9-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) HWTHWPBGOLUDQA-UHFFFAOYSA-N 50165865 CHEMBL3798423::US9550781, 23 Serine/threonine-protein kinase B-raf Homo sapiens 83 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165865&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71570866 341097717 CHEMBL3798423 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493183 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H14F2N8O2S/c22-14-5-6-15(31-34(32,33)12-3-1-7-24-9-12)16(23)18(14)30-20-13(4-2-8-25-20)17-19-21(28-10-26-17)29-11-27-19/h1-11,31H,(H,25,30)(H,26,27,28,29) JTESGLUEGOKQOX-UHFFFAOYSA-N 197701 US9216981, 30 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197701&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345328 318488818 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493184 Fc1ccc(NS(=O)(=O)c2ccccn2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H14F2N8O2S/c22-13-6-7-14(31-34(32,33)15-5-1-2-8-24-15)16(23)18(13)30-20-12(4-3-9-25-20)17-19-21(28-10-26-17)29-11-27-19/h1-11,31H,(H,25,30)(H,26,27,28,29) AVXOLCIHZKRJSD-UHFFFAOYSA-N 50165866 CHEMBL3799483 Serine/threonine-protein kinase B-raf Homo sapiens 41 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165866&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127045991 341097718 CHEMBL3799483 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493185 Fc1ccc(NS(=O)(=O)c2cccs2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H13F2N7O2S2/c21-12-5-6-13(29-33(30,31)14-4-2-8-32-14)15(22)17(12)28-19-11(3-1-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-10,29H,(H,23,28)(H,24,25,26,27) AUPADWFQWOIWBW-UHFFFAOYSA-N 197676 US9216981, 4 Serine/threonine-protein kinase B-raf Homo sapiens 0.500000 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197676&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344794 318488793 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493186 Fc1ccc(NS(=O)(=O)c2nccs2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C19H12F2N8O2S2/c20-11-3-4-12(29-33(30,31)19-23-6-7-32-19)13(21)15(11)28-17-10(2-1-5-22-17)14-16-18(26-8-24-14)27-9-25-16/h1-9,29H,(H,22,28)(H,24,25,26,27) XKEIGURBFSAWSQ-UHFFFAOYSA-N 50165868 CHEMBL3800081 Serine/threonine-protein kinase B-raf Homo sapiens 2.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165868&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127045769 341097719 CHEMBL3800081 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493187 Fc1ccc(NS(=O)(=O)c2cn[nH]c2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C19H13F2N9O2S/c20-12-3-4-13(30-33(31,32)10-6-27-28-7-10)14(21)16(12)29-18-11(2-1-5-22-18)15-17-19(25-8-23-15)26-9-24-17/h1-9,30H,(H,22,29)(H,27,28)(H,23,24,25,26) ZFTVIODRJLZDMA-UHFFFAOYSA-N 50165870 CHEMBL3797403 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165870&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127045770 341097720 CHEMBL3797403 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493188 Cn1cc(cn1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H15F2N9O2S/c1-31-8-11(7-28-31)34(32,33)30-14-5-4-13(21)17(15(14)22)29-19-12(3-2-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h2-10,30H,1H3,(H,23,29)(H,24,25,26,27) MFGDWGYOUFSTFA-UHFFFAOYSA-N 197714 US9216981, 43 Serine/threonine-protein kinase B-raf Homo sapiens 19 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197714&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343972 318488831 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493189 CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C17H13F2N7O2S/c1-29(27,28)26-11-5-4-10(18)14(12(11)19)25-16-9(3-2-6-20-16)13-15-17(23-7-21-13)24-8-22-15/h2-8,26H,1H3,(H,20,25)(H,21,22,23,24) WCNKFDYACPTVPO-UHFFFAOYSA-N 50165871 CHEMBL3798635::US9550781, 13 Serine/threonine-protein kinase B-raf Homo sapiens 412 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165871&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71570573 341097721 CHEMBL3798635 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493190 CCCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H17F2N7O2S/c1-2-8-31(29,30)28-13-6-5-12(20)16(14(13)21)27-18-11(4-3-7-22-18)15-17-19(25-9-23-15)26-10-24-17/h3-7,9-10,28H,2,8H2,1H3,(H,22,27)(H,23,24,25,26) ZCFRMOFRDWXLRB-UHFFFAOYSA-N 197677 US9216981, 5::US9550781, 1 Serine/threonine-protein kinase B-raf Homo sapiens 12 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197677&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344795 318488794 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493191 Fc1ccc(NS(=O)(=O)CC(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C18H12F5N7O2S/c19-10-3-4-11(30-33(31,32)6-18(21,22)23)12(20)14(10)29-16-9(2-1-5-24-16)13-15-17(27-7-25-13)28-8-26-15/h1-5,7-8,30H,6H2,(H,24,29)(H,25,26,27,28) PWEHFDUGZVTNNL-UHFFFAOYSA-N 50165873 CHEMBL3800014::US9550781, 19 Serine/threonine-protein kinase B-raf Homo sapiens 10.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165873&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71570722 341097722 CHEMBL3800014 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493192 CC(C)CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H19F2N7O2S/c1-11(2)8-32(30,31)29-14-6-5-13(21)17(15(14)22)28-19-12(4-3-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h3-7,9-11,29H,8H2,1-2H3,(H,23,28)(H,24,25,26,27) QWFFFUZGWWOIMW-UHFFFAOYSA-N 50165874 CHEMBL3799488 Serine/threonine-protein kinase B-raf Homo sapiens 16 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165874&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046445 341097723 CHEMBL3799488 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493193 Fc1ccc(NS(=O)(=O)CC2CC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H17F2N7O2S/c21-13-5-6-14(29-32(30,31)8-11-3-4-11)15(22)17(13)28-19-12(2-1-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-2,5-7,9-11,29H,3-4,8H2,(H,23,28)(H,24,25,26,27) YPINALOZMFRIOO-UHFFFAOYSA-N 50165875 CHEMBL3798570 Serine/threonine-protein kinase B-raf Homo sapiens 26 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165875&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046446 341097724 CHEMBL3798570 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493194 CC(C)(C)CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C21H21F2N7O2S/c1-21(2,3)9-33(31,32)30-14-7-6-13(22)17(15(14)23)29-19-12(5-4-8-24-19)16-18-20(27-10-25-16)28-11-26-18/h4-8,10-11,30H,9H2,1-3H3,(H,24,29)(H,25,26,27,28) SMQPPWBGDWYCFJ-UHFFFAOYSA-N 50165856 CHEMBL3799342 Serine/threonine-protein kinase B-raf Homo sapiens 5.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165856&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046615 104051354 CHEMBL3799342 ZINC28524535 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493195 Fc1ccc(NS(=O)(=O)Cc2ccccc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C23H17F2N7O2S/c24-16-8-9-17(32-35(33,34)11-14-5-2-1-3-6-14)18(25)20(16)31-22-15(7-4-10-26-22)19-21-23(29-12-27-19)30-13-28-21/h1-10,12-13,32H,11H2,(H,26,31)(H,27,28,29,30) KXZXQWZNHDHQET-UHFFFAOYSA-N 50165857 CHEMBL3800157 Serine/threonine-protein kinase B-raf Homo sapiens 111 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165857&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047893 104051355 CHEMBL3800157 ZINC28522120 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493196 CC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H17F2N7O2S/c1-10(2)31(29,30)28-13-6-5-12(20)16(14(13)21)27-18-11(4-3-7-22-18)15-17-19(25-8-23-15)26-9-24-17/h3-10,28H,1-2H3,(H,22,27)(H,23,24,25,26) LJGJKSMJLUENHX-UHFFFAOYSA-N 197673 US9216981, 1 Serine/threonine-protein kinase B-raf Homo sapiens 66 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344791 318488790 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493197 CCC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H19F2N7O2S/c1-3-11(2)32(30,31)29-14-7-6-13(21)17(15(14)22)28-19-12(5-4-8-23-19)16-18-20(26-9-24-16)27-10-25-18/h4-11,29H,3H2,1-2H3,(H,23,28)(H,24,25,26,27) XMFJRQPXMQXCTL-UHFFFAOYSA-N 50165858 CHEMBL3800227 Serine/threonine-protein kinase B-raf Homo sapiens 38 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165858&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048021 341097711 CHEMBL3800227 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493198 CCCC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C21H21F2N7O2S/c1-3-5-12(2)33(31,32)30-15-8-7-14(22)18(16(15)23)29-20-13(6-4-9-24-20)17-19-21(27-10-25-17)28-11-26-19/h4,6-12,30H,3,5H2,1-2H3,(H,24,29)(H,25,26,27,28) KASOTWCGKVLVEN-UHFFFAOYSA-N 50165859 CHEMBL3799288 Serine/threonine-protein kinase B-raf Homo sapiens 112 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165859&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048022 341097712 CHEMBL3799288 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493199 Fc1ccc(NS(=O)(=O)C2CC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C19H15F2N7O2S/c20-12-5-6-13(28-31(29,30)10-3-4-10)14(21)16(12)27-18-11(2-1-7-22-18)15-17-19(25-8-23-15)26-9-24-17/h1-2,5-10,28H,3-4H2,(H,22,27)(H,23,24,25,26) SMMQTLKZQUWOFV-UHFFFAOYSA-N 197690 US9216981, 19 Serine/threonine-protein kinase B-raf Homo sapiens 132 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197690&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345095 318488807 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493200 Fc1ccc(NS(=O)(=O)C2CCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H17F2N7O2S/c21-13-6-7-14(29-32(30,31)11-3-1-4-11)15(22)17(13)28-19-12(5-2-8-23-19)16-18-20(26-9-24-16)27-10-25-18/h2,5-11,29H,1,3-4H2,(H,23,28)(H,24,25,26,27) JONADRDDUBKXHN-UHFFFAOYSA-N 50165860 CHEMBL3798630 Serine/threonine-protein kinase B-raf Homo sapiens 46 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165860&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048023 341097713 CHEMBL3798630 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493201 Fc1ccc(NS(=O)(=O)C2CCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H19F2N7O2S/c22-14-7-8-15(30-33(31,32)12-4-1-2-5-12)16(23)18(14)29-20-13(6-3-9-24-20)17-19-21(27-10-25-17)28-11-26-19/h3,6-12,30H,1-2,4-5H2,(H,24,29)(H,25,26,27,28) JYFROOXDYMGYMV-UHFFFAOYSA-N 50165876 CHEMBL3800364 Serine/threonine-protein kinase B-raf Homo sapiens 21 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165876&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047243 341097725 CHEMBL3800364 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493202 Fc1ccc(NS(=O)(=O)C2CCOC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H17F2N7O3S/c21-13-3-4-14(29-33(30,31)11-5-7-32-8-11)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-4,6,9-11,29H,5,7-8H2,(H,23,28)(H,24,25,26,27) FVFZJRXMBNFYKM-UHFFFAOYSA-N 50165878 CHEMBL3798235 Serine/threonine-protein kinase B-raf Homo sapiens 26 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165878&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047244 341097726 CHEMBL3798235 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493203 Fc1ccc(NS(=O)(=O)C2CCCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H21F2N7O2S/c23-15-8-9-16(31-34(32,33)13-5-2-1-3-6-13)17(24)19(15)30-21-14(7-4-10-25-21)18-20-22(28-11-26-18)29-12-27-20/h4,7-13,31H,1-3,5-6H2,(H,25,30)(H,26,27,28,29) HELVMFLMFAYVHW-UHFFFAOYSA-N 197683 US9216981, 11 Serine/threonine-protein kinase B-raf Homo sapiens 51 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197683&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344993 318488800 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493204 Fc1ccc(NS(=O)(=O)C2CCOCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H19F2N7O3S/c22-14-3-4-15(30-34(31,32)12-5-8-33-9-6-12)16(23)18(14)29-20-13(2-1-7-24-20)17-19-21(27-10-25-17)28-11-26-19/h1-4,7,10-12,30H,5-6,8-9H2,(H,24,29)(H,25,26,27,28) STVYRNAAKPYOJY-UHFFFAOYSA-N 50165879 CHEMBL3798516 Serine/threonine-protein kinase B-raf Homo sapiens 179 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165879&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047245 341097727 CHEMBL3798516 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493205 CN(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C18H16F2N8O2S/c1-28(2)31(29,30)27-12-6-5-11(19)15(13(12)20)26-17-10(4-3-7-21-17)14-16-18(24-8-22-14)25-9-23-16/h3-9,27H,1-2H3,(H,21,26)(H,22,23,24,25) DFMZBEXLPWVTSV-UHFFFAOYSA-N 50165880 CHEMBL3798256 Serine/threonine-protein kinase B-raf Homo sapiens 90 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165880&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118988423 341097728 CHEMBL3798256 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493206 CCN(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H18F2N8O2S/c1-3-29(2)32(30,31)28-13-7-6-12(20)16(14(13)21)27-18-11(5-4-8-22-18)15-17-19(25-9-23-15)26-10-24-17/h4-10,28H,3H2,1-2H3,(H,22,27)(H,23,24,25,26) AFSMOIAGUMMQNG-UHFFFAOYSA-N 50165881 CHEMBL3797223 Serine/threonine-protein kinase B-raf Homo sapiens 157 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165881&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047246 341097729 CHEMBL3797223 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493207 CCN(CC)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H20F2N8O2S/c1-3-30(4-2)33(31,32)29-14-8-7-13(21)17(15(14)22)28-19-12(6-5-9-23-19)16-18-20(26-10-24-16)27-11-25-18/h5-11,29H,3-4H2,1-2H3,(H,23,28)(H,24,25,26,27) QKCAIQUAPOMAIJ-UHFFFAOYSA-N 50165883 CHEMBL3797353 Serine/threonine-protein kinase B-raf Homo sapiens 165 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165883&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046079 341097730 CHEMBL3797353 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493208 Fc1ccc(NS(=O)(=O)N2CCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H18F2N8O2S/c21-13-5-6-14(29-33(31,32)30-8-1-2-9-30)15(22)17(13)28-19-12(4-3-7-23-19)16-18-20(26-10-24-16)27-11-25-18/h3-7,10-11,29H,1-2,8-9H2,(H,23,28)(H,24,25,26,27) KBAJWXYBQYEMSD-UHFFFAOYSA-N 50165884 CHEMBL3799949 Serine/threonine-protein kinase B-raf Homo sapiens 31 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165884&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046080 341097731 CHEMBL3799949 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493209 Fc1ccc(NS(=O)(=O)N2CCCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H20F2N8O2S/c22-14-6-7-15(30-34(32,33)31-9-2-1-3-10-31)16(23)18(14)29-20-13(5-4-8-24-20)17-19-21(27-11-25-17)28-12-26-19/h4-8,11-12,30H,1-3,9-10H2,(H,24,29)(H,25,26,27,28) IZHJQYWDFVOZBF-UHFFFAOYSA-N 50165885 CHEMBL3798505 Serine/threonine-protein kinase B-raf Homo sapiens 38 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165885&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046081 341097732 CHEMBL3798505 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493210 O[C@H]1CCN(C1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H18F2N8O3S/c21-13-3-4-14(29-34(32,33)30-7-5-11(31)8-30)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-4,6,9-11,29,31H,5,7-8H2,(H,23,28)(H,24,25,26,27)/t11-/m0/s1 ZHQDXUJBHCRZBE-NSHDSACASA-N 50165886 CHEMBL3800002 Serine/threonine-protein kinase B-raf Homo sapiens 122 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165886&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046082 341097733 CHEMBL3800002 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493211 O[C@@H]1CCN(C1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H18F2N8O3S/c21-13-3-4-14(29-34(32,33)30-7-5-11(31)8-30)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-4,6,9-11,29,31H,5,7-8H2,(H,23,28)(H,24,25,26,27)/t11-/m1/s1 ZHQDXUJBHCRZBE-LLVKDONJSA-N 50165887 CHEMBL3797494 Serine/threonine-protein kinase B-raf Homo sapiens 68 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165887&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046289 341097734 CHEMBL3797494 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493212 Fc1ccc(NS(=O)(=O)N2CCOCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H18F2N8O3S/c21-13-3-4-14(29-34(31,32)30-6-8-33-9-7-30)15(22)17(13)28-19-12(2-1-5-23-19)16-18-20(26-10-24-16)27-11-25-18/h1-5,10-11,29H,6-9H2,(H,23,28)(H,24,25,26,27) PVLBWLQBZCGLQR-UHFFFAOYSA-N 197692 US9216981, 21 Serine/threonine-protein kinase B-raf Homo sapiens 102 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197692&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345097 318488809 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493213 Fc1ccc(NS(=O)(=O)N2CCNCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H19F2N9O2S/c21-13-3-4-14(30-34(32,33)31-8-6-23-7-9-31)15(22)17(13)29-19-12(2-1-5-24-19)16-18-20(27-10-25-16)28-11-26-18/h1-5,10-11,23,30H,6-9H2,(H,24,29)(H,25,26,27,28) INHDDMDMADEERR-UHFFFAOYSA-N 50165888 CHEMBL3799046 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165888&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047676 341097735 CHEMBL3799046 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493214 Fc1ccc(NS(=O)(=O)N2CCNCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H19F2N9O2S/c21-13-3-4-14(30-34(32,33)31-8-6-23-7-9-31)15(22)17(13)29-19-12(2-1-5-24-19)16-18-20(27-10-25-16)28-11-26-18/h1-5,10-11,23,30H,6-9H2,(H,24,29)(H,25,26,27,28) INHDDMDMADEERR-UHFFFAOYSA-N 50165888 CHEMBL3799046 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165888&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047676 341097735 CHEMBL3799046 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493215 Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C26H19ClN8/c1-15-4-9-19-18(10-12-29-24(19)34-17-7-5-16(27)6-8-17)21(15)35-25-20(3-2-11-28-25)22-23-26(32-13-30-22)33-14-31-23/h2-14H,1H3,(H,28,35)(H,29,34)(H,30,31,32,33) KKVYYGGCHJGEFJ-UHFFFAOYSA-N 50165861 CHEMBL1197798 Serine/threonine-protein kinase B-raf Homo sapiens 22 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165861&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44223999 341097714 CHEMBL1197798 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493216 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 2290 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493217 CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29) BFSMGDJOXZAERB-UHFFFAOYSA-N 50428286 DABRAFENIB::GSK2118436A Serine/threonine-protein kinase B-raf Homo sapiens 529 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50428286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50428286&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search P06 7RIV,4XV2,5CSW,6HJ2,6V2U,5HIE 44462760 164157161 75045 DB08912 ZINC68153186 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493218 Fc1ccc(NS(=O)(=O)c2ccccc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H15F2N7O2S/c23-15-8-9-16(31-34(32,33)13-5-2-1-3-6-13)17(24)19(15)30-21-14(7-4-10-25-21)18-20-22(28-11-26-18)29-12-27-20/h1-12,31H,(H,25,30)(H,26,27,28,29) UHPAFPKCOMSYMO-UHFFFAOYSA-N 197706 US9216981, 35::US9550781, 15 Serine/threonine-protein kinase B-raf Homo sapiens 2290 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197706&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343766 318488823 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493219 Fc1ccc(NS(=O)(=O)c2ccccc2F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H14F3N7O2S/c23-13-5-1-2-6-16(13)35(33,34)32-15-8-7-14(24)19(17(15)25)31-21-12(4-3-9-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) ILBNLHRNSBVYOE-UHFFFAOYSA-N 50165863 CHEMBL3800226 Serine/threonine-protein kinase B-raf Homo sapiens 873 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165863&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047050 341097715 CHEMBL3800226 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493220 Fc1cccc(c1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H14F3N7O2S/c23-12-3-1-4-13(9-12)35(33,34)32-16-7-6-15(24)19(17(16)25)31-21-14(5-2-8-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) NAMHUPSTGXJBQO-UHFFFAOYSA-N 50165864 CHEMBL3799014 Serine/threonine-protein kinase B-raf Homo sapiens 1510 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165864&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047051 341097716 CHEMBL3799014 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493221 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H14F3N7O2S/c23-12-3-5-13(6-4-12)35(33,34)32-16-8-7-15(24)19(17(16)25)31-21-14(2-1-9-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) HWTHWPBGOLUDQA-UHFFFAOYSA-N 50165865 CHEMBL3798423::US9550781, 23 Serine/threonine-protein kinase B-raf Homo sapiens 5650 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165865&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71570866 341097717 CHEMBL3798423 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493222 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H14F2N8O2S/c22-14-5-6-15(31-34(32,33)12-3-1-7-24-9-12)16(23)18(14)30-20-13(4-2-8-25-20)17-19-21(28-10-26-17)29-11-27-19/h1-11,31H,(H,25,30)(H,26,27,28,29) JTESGLUEGOKQOX-UHFFFAOYSA-N 197701 US9216981, 30 Serine/threonine-protein kinase B-raf Homo sapiens 786 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197701&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345328 318488818 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493223 Fc1ccc(NS(=O)(=O)c2ccccn2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H14F2N8O2S/c22-13-6-7-14(31-34(32,33)15-5-1-2-8-24-15)16(23)18(13)30-20-12(4-3-9-25-20)17-19-21(28-10-26-17)29-11-27-19/h1-11,31H,(H,25,30)(H,26,27,28,29) AVXOLCIHZKRJSD-UHFFFAOYSA-N 50165866 CHEMBL3799483 Serine/threonine-protein kinase B-raf Homo sapiens 7940 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165866&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127045991 341097718 CHEMBL3799483 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493225 Fc1ccc(NS(=O)(=O)c2cccs2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H13F2N7O2S2/c21-12-5-6-13(29-33(30,31)14-4-2-8-32-14)15(22)17(12)28-19-11(3-1-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-10,29H,(H,23,28)(H,24,25,26,27) AUPADWFQWOIWBW-UHFFFAOYSA-N 197676 US9216981, 4 Serine/threonine-protein kinase B-raf Homo sapiens 402 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197676&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344794 318488793 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493226 Fc1ccc(NS(=O)(=O)c2nccs2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C19H12F2N8O2S2/c20-11-3-4-12(29-33(30,31)19-23-6-7-32-19)13(21)15(11)28-17-10(2-1-5-22-17)14-16-18(26-8-24-14)27-9-25-16/h1-9,29H,(H,22,28)(H,24,25,26,27) XKEIGURBFSAWSQ-UHFFFAOYSA-N 50165868 CHEMBL3800081 Serine/threonine-protein kinase B-raf Homo sapiens 783 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165868&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127045769 341097719 CHEMBL3800081 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493228 Fc1ccc(NS(=O)(=O)c2cn[nH]c2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C19H13F2N9O2S/c20-12-3-4-13(30-33(31,32)10-6-27-28-7-10)14(21)16(12)29-18-11(2-1-5-22-18)15-17-19(25-8-23-15)26-9-24-17/h1-9,30H,(H,22,29)(H,27,28)(H,23,24,25,26) ZFTVIODRJLZDMA-UHFFFAOYSA-N 50165870 CHEMBL3797403 Serine/threonine-protein kinase B-raf Homo sapiens 807 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165870&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127045770 341097720 CHEMBL3797403 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493229 Cn1cc(cn1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H15F2N9O2S/c1-31-8-11(7-28-31)34(32,33)30-14-5-4-13(21)17(15(14)22)29-19-12(3-2-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h2-10,30H,1H3,(H,23,29)(H,24,25,26,27) MFGDWGYOUFSTFA-UHFFFAOYSA-N 197714 US9216981, 43 Serine/threonine-protein kinase B-raf Homo sapiens 2220 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197714&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343972 318488831 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493230 CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C17H13F2N7O2S/c1-29(27,28)26-11-5-4-10(18)14(12(11)19)25-16-9(3-2-6-20-16)13-15-17(23-7-21-13)24-8-22-15/h2-8,26H,1H3,(H,20,25)(H,21,22,23,24) WCNKFDYACPTVPO-UHFFFAOYSA-N 50165871 CHEMBL3798635::US9550781, 13 Serine/threonine-protein kinase B-raf Homo sapiens 6690 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165871&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71570573 341097721 CHEMBL3798635 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493231 CCCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H17F2N7O2S/c1-2-8-31(29,30)28-13-6-5-12(20)16(14(13)21)27-18-11(4-3-7-22-18)15-17-19(25-9-23-15)26-10-24-17/h3-7,9-10,28H,2,8H2,1H3,(H,22,27)(H,23,24,25,26) ZCFRMOFRDWXLRB-UHFFFAOYSA-N 197677 US9216981, 5::US9550781, 1 Serine/threonine-protein kinase B-raf Homo sapiens 936 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197677&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344795 318488794 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493232 Fc1ccc(NS(=O)(=O)CC(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C18H12F5N7O2S/c19-10-3-4-11(30-33(31,32)6-18(21,22)23)12(20)14(10)29-16-9(2-1-5-24-16)13-15-17(27-7-25-13)28-8-26-15/h1-5,7-8,30H,6H2,(H,24,29)(H,25,26,27,28) PWEHFDUGZVTNNL-UHFFFAOYSA-N 50165873 CHEMBL3800014::US9550781, 19 Serine/threonine-protein kinase B-raf Homo sapiens 713 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165873&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71570722 341097722 CHEMBL3800014 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493233 CC(C)CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H19F2N7O2S/c1-11(2)8-32(30,31)29-14-6-5-13(21)17(15(14)22)28-19-12(4-3-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h3-7,9-11,29H,8H2,1-2H3,(H,23,28)(H,24,25,26,27) QWFFFUZGWWOIMW-UHFFFAOYSA-N 50165874 CHEMBL3799488 Serine/threonine-protein kinase B-raf Homo sapiens 1450 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165874&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046445 341097723 CHEMBL3799488 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493234 Fc1ccc(NS(=O)(=O)CC2CC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H17F2N7O2S/c21-13-5-6-14(29-32(30,31)8-11-3-4-11)15(22)17(13)28-19-12(2-1-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-2,5-7,9-11,29H,3-4,8H2,(H,23,28)(H,24,25,26,27) YPINALOZMFRIOO-UHFFFAOYSA-N 50165875 CHEMBL3798570 Serine/threonine-protein kinase B-raf Homo sapiens 2140 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165875&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046446 341097724 CHEMBL3798570 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493235 CC(C)(C)CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C21H21F2N7O2S/c1-21(2,3)9-33(31,32)30-14-7-6-13(22)17(15(14)23)29-19-12(5-4-8-24-19)16-18-20(27-10-25-16)28-11-26-18/h4-8,10-11,30H,9H2,1-3H3,(H,24,29)(H,25,26,27,28) SMQPPWBGDWYCFJ-UHFFFAOYSA-N 50165856 CHEMBL3799342 Serine/threonine-protein kinase B-raf Homo sapiens 202 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165856&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046615 104051354 CHEMBL3799342 ZINC28524535 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493236 Fc1ccc(NS(=O)(=O)Cc2ccccc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C23H17F2N7O2S/c24-16-8-9-17(32-35(33,34)11-14-5-2-1-3-6-14)18(25)20(16)31-22-15(7-4-10-26-22)19-21-23(29-12-27-19)30-13-28-21/h1-10,12-13,32H,11H2,(H,26,31)(H,27,28,29,30) KXZXQWZNHDHQET-UHFFFAOYSA-N 50165857 CHEMBL3800157 Serine/threonine-protein kinase B-raf Homo sapiens 5080 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165857&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047893 104051355 CHEMBL3800157 ZINC28522120 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493237 CC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H17F2N7O2S/c1-10(2)31(29,30)28-13-6-5-12(20)16(14(13)21)27-18-11(4-3-7-22-18)15-17-19(25-8-23-15)26-9-24-17/h3-10,28H,1-2H3,(H,22,27)(H,23,24,25,26) LJGJKSMJLUENHX-UHFFFAOYSA-N 197673 US9216981, 1 Serine/threonine-protein kinase B-raf Homo sapiens 1540 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344791 318488790 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493238 CCC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H19F2N7O2S/c1-3-11(2)32(30,31)29-14-7-6-13(21)17(15(14)22)28-19-12(5-4-8-23-19)16-18-20(26-9-24-16)27-10-25-18/h4-11,29H,3H2,1-2H3,(H,23,28)(H,24,25,26,27) XMFJRQPXMQXCTL-UHFFFAOYSA-N 50165858 CHEMBL3800227 Serine/threonine-protein kinase B-raf Homo sapiens 778 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165858&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048021 341097711 CHEMBL3800227 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493239 CCCC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C21H21F2N7O2S/c1-3-5-12(2)33(31,32)30-15-8-7-14(22)18(16(15)23)29-20-13(6-4-9-24-20)17-19-21(27-10-25-17)28-11-26-19/h4,6-12,30H,3,5H2,1-2H3,(H,24,29)(H,25,26,27,28) KASOTWCGKVLVEN-UHFFFAOYSA-N 50165859 CHEMBL3799288 Serine/threonine-protein kinase B-raf Homo sapiens 8090 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165859&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048022 341097712 CHEMBL3799288 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493240 Fc1ccc(NS(=O)(=O)C2CC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C19H15F2N7O2S/c20-12-5-6-13(28-31(29,30)10-3-4-10)14(21)16(12)27-18-11(2-1-7-22-18)15-17-19(25-8-23-15)26-9-24-17/h1-2,5-10,28H,3-4H2,(H,22,27)(H,23,24,25,26) SMMQTLKZQUWOFV-UHFFFAOYSA-N 197690 US9216981, 19 Serine/threonine-protein kinase B-raf Homo sapiens 2070 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197690&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345095 318488807 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493241 Fc1ccc(NS(=O)(=O)C2CCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H17F2N7O2S/c21-13-6-7-14(29-32(30,31)11-3-1-4-11)15(22)17(13)28-19-12(5-2-8-23-19)16-18-20(26-9-24-16)27-10-25-18/h2,5-11,29H,1,3-4H2,(H,23,28)(H,24,25,26,27) JONADRDDUBKXHN-UHFFFAOYSA-N 50165860 CHEMBL3798630 Serine/threonine-protein kinase B-raf Homo sapiens 1790 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165860&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048023 341097713 CHEMBL3798630 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493242 Fc1ccc(NS(=O)(=O)C2CCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H19F2N7O2S/c22-14-7-8-15(30-33(31,32)12-4-1-2-5-12)16(23)18(14)29-20-13(6-3-9-24-20)17-19-21(27-10-25-17)28-11-26-19/h3,6-12,30H,1-2,4-5H2,(H,24,29)(H,25,26,27,28) JYFROOXDYMGYMV-UHFFFAOYSA-N 50165876 CHEMBL3800364 Serine/threonine-protein kinase B-raf Homo sapiens 1800 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165876&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047243 341097725 CHEMBL3800364 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493243 Fc1ccc(NS(=O)(=O)C2CCOC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H17F2N7O3S/c21-13-3-4-14(29-33(30,31)11-5-7-32-8-11)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-4,6,9-11,29H,5,7-8H2,(H,23,28)(H,24,25,26,27) FVFZJRXMBNFYKM-UHFFFAOYSA-N 50165878 CHEMBL3798235 Serine/threonine-protein kinase B-raf Homo sapiens 1480 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165878&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047244 341097726 CHEMBL3798235 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493244 Fc1ccc(NS(=O)(=O)C2CCCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H21F2N7O2S/c23-15-8-9-16(31-34(32,33)13-5-2-1-3-6-13)17(24)19(15)30-21-14(7-4-10-25-21)18-20-22(28-11-26-18)29-12-27-20/h4,7-13,31H,1-3,5-6H2,(H,25,30)(H,26,27,28,29) HELVMFLMFAYVHW-UHFFFAOYSA-N 197683 US9216981, 11 Serine/threonine-protein kinase B-raf Homo sapiens 4370 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197683&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344993 318488800 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493245 CN(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C18H16F2N8O2S/c1-28(2)31(29,30)27-12-6-5-11(19)15(13(12)20)26-17-10(4-3-7-21-17)14-16-18(24-8-22-14)25-9-23-16/h3-9,27H,1-2H3,(H,21,26)(H,22,23,24,25) DFMZBEXLPWVTSV-UHFFFAOYSA-N 50165880 CHEMBL3798256 Serine/threonine-protein kinase B-raf Homo sapiens 1780 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165880&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118988423 341097728 CHEMBL3798256 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493246 CCN(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H18F2N8O2S/c1-3-29(2)32(30,31)28-13-7-6-12(20)16(14(13)21)27-18-11(5-4-8-22-18)15-17-19(25-9-23-15)26-10-24-17/h4-10,28H,3H2,1-2H3,(H,22,27)(H,23,24,25,26) AFSMOIAGUMMQNG-UHFFFAOYSA-N 50165881 CHEMBL3797223 Serine/threonine-protein kinase B-raf Homo sapiens 1780 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165881&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047246 341097729 CHEMBL3797223 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493247 CCN(CC)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H20F2N8O2S/c1-3-30(4-2)33(31,32)29-14-8-7-13(21)17(15(14)22)28-19-12(6-5-9-23-19)16-18-20(26-10-24-16)27-11-25-18/h5-11,29H,3-4H2,1-2H3,(H,23,28)(H,24,25,26,27) QKCAIQUAPOMAIJ-UHFFFAOYSA-N 50165883 CHEMBL3797353 Serine/threonine-protein kinase B-raf Homo sapiens 9910 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165883&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046079 341097730 CHEMBL3797353 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493248 Fc1ccc(NS(=O)(=O)N2CCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H18F2N8O2S/c21-13-5-6-14(29-33(31,32)30-8-1-2-9-30)15(22)17(13)28-19-12(4-3-7-23-19)16-18-20(26-10-24-16)27-11-25-18/h3-7,10-11,29H,1-2,8-9H2,(H,23,28)(H,24,25,26,27) KBAJWXYBQYEMSD-UHFFFAOYSA-N 50165884 CHEMBL3799949 Serine/threonine-protein kinase B-raf Homo sapiens 2070 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165884&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046080 341097731 CHEMBL3799949 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493249 Fc1ccc(NS(=O)(=O)N2CCCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H20F2N8O2S/c22-14-6-7-15(30-34(32,33)31-9-2-1-3-10-31)16(23)18(14)29-20-13(5-4-8-24-20)17-19-21(27-11-25-17)28-12-26-19/h4-8,11-12,30H,1-3,9-10H2,(H,24,29)(H,25,26,27,28) IZHJQYWDFVOZBF-UHFFFAOYSA-N 50165885 CHEMBL3798505 Serine/threonine-protein kinase B-raf Homo sapiens 1220 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165885&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046081 341097732 CHEMBL3798505 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493250 O[C@@H]1CCN(C1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H18F2N8O3S/c21-13-3-4-14(29-34(32,33)30-7-5-11(31)8-30)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-4,6,9-11,29,31H,5,7-8H2,(H,23,28)(H,24,25,26,27)/t11-/m1/s1 ZHQDXUJBHCRZBE-LLVKDONJSA-N 50165887 CHEMBL3797494 Serine/threonine-protein kinase B-raf Homo sapiens 7190 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165887&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046289 341097734 CHEMBL3797494 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493251 Fc1ccc(NS(=O)(=O)N2CCOCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H18F2N8O3S/c21-13-3-4-14(29-34(31,32)30-6-8-33-9-7-30)15(22)17(13)28-19-12(2-1-5-23-19)16-18-20(26-10-24-16)27-11-25-18/h1-5,10-11,29H,6-9H2,(H,23,28)(H,24,25,26,27) PVLBWLQBZCGLQR-UHFFFAOYSA-N 197692 US9216981, 21 Serine/threonine-protein kinase B-raf Homo sapiens 3580 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197692&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345097 318488809 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493252 Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C26H19ClN8/c1-15-4-9-19-18(10-12-29-24(19)34-17-7-5-16(27)6-8-17)21(15)35-25-20(3-2-11-28-25)22-23-26(32-13-30-22)33-14-31-23/h2-14H,1H3,(H,28,35)(H,29,34)(H,30,31,32,33) KKVYYGGCHJGEFJ-UHFFFAOYSA-N 50165861 CHEMBL1197798 Serine/threonine-protein kinase B-raf Homo sapiens 2.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165861&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44223999 341097714 CHEMBL1197798 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493253 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 17 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493254 CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29) BFSMGDJOXZAERB-UHFFFAOYSA-N 50428286 DABRAFENIB::GSK2118436A Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50428286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50428286&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search P06 7RIV,4XV2,5CSW,6HJ2,6V2U,5HIE 44462760 164157161 75045 DB08912 ZINC68153186 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493255 Fc1ccc(NS(=O)(=O)c2ccccc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H15F2N7O2S/c23-15-8-9-16(31-34(32,33)13-5-2-1-3-6-13)17(24)19(15)30-21-14(7-4-10-25-21)18-20-22(28-11-26-18)29-12-27-20/h1-12,31H,(H,25,30)(H,26,27,28,29) UHPAFPKCOMSYMO-UHFFFAOYSA-N 197706 US9216981, 35::US9550781, 15 Serine/threonine-protein kinase B-raf Homo sapiens 28 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197706&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343766 318488823 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493256 Fc1ccc(NS(=O)(=O)c2ccccc2F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H14F3N7O2S/c23-13-5-1-2-6-16(13)35(33,34)32-15-8-7-14(24)19(17(15)25)31-21-12(4-3-9-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) ILBNLHRNSBVYOE-UHFFFAOYSA-N 50165863 CHEMBL3800226 Serine/threonine-protein kinase B-raf Homo sapiens 12 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165863&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047050 341097715 CHEMBL3800226 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493257 Fc1cccc(c1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H14F3N7O2S/c23-12-3-1-4-13(9-12)35(33,34)32-16-7-6-15(24)19(17(16)25)31-21-14(5-2-8-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) NAMHUPSTGXJBQO-UHFFFAOYSA-N 50165864 CHEMBL3799014 Serine/threonine-protein kinase B-raf Homo sapiens 15 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165864&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047051 341097716 CHEMBL3799014 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493258 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H14F3N7O2S/c23-12-3-5-13(6-4-12)35(33,34)32-16-8-7-15(24)19(17(16)25)31-21-14(2-1-9-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) HWTHWPBGOLUDQA-UHFFFAOYSA-N 50165865 CHEMBL3798423::US9550781, 23 Serine/threonine-protein kinase B-raf Homo sapiens 242 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165865&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71570866 341097717 CHEMBL3798423 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493259 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H14F2N8O2S/c22-14-5-6-15(31-34(32,33)12-3-1-7-24-9-12)16(23)18(14)30-20-13(4-2-8-25-20)17-19-21(28-10-26-17)29-11-27-19/h1-11,31H,(H,25,30)(H,26,27,28,29) JTESGLUEGOKQOX-UHFFFAOYSA-N 197701 US9216981, 30 Serine/threonine-protein kinase B-raf Homo sapiens 10.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197701&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345328 318488818 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493260 Fc1ccc(NS(=O)(=O)c2ccccn2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H14F2N8O2S/c22-13-6-7-14(31-34(32,33)15-5-1-2-8-24-15)16(23)18(13)30-20-12(4-3-9-25-20)17-19-21(28-10-26-17)29-11-27-19/h1-11,31H,(H,25,30)(H,26,27,28,29) AVXOLCIHZKRJSD-UHFFFAOYSA-N 50165866 CHEMBL3799483 Serine/threonine-protein kinase B-raf Homo sapiens 177 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165866&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127045991 341097718 CHEMBL3799483 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493261 Fc1ccc(NS(=O)(=O)c2cccs2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H13F2N7O2S2/c21-12-5-6-13(29-33(30,31)14-4-2-8-32-14)15(22)17(12)28-19-11(3-1-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-10,29H,(H,23,28)(H,24,25,26,27) AUPADWFQWOIWBW-UHFFFAOYSA-N 197676 US9216981, 4 Serine/threonine-protein kinase B-raf Homo sapiens 7.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197676&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344794 318488793 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493262 Fc1ccc(NS(=O)(=O)c2nccs2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C19H12F2N8O2S2/c20-11-3-4-12(29-33(30,31)19-23-6-7-32-19)13(21)15(11)28-17-10(2-1-5-22-17)14-16-18(26-8-24-14)27-9-25-16/h1-9,29H,(H,22,28)(H,24,25,26,27) XKEIGURBFSAWSQ-UHFFFAOYSA-N 50165868 CHEMBL3800081 Serine/threonine-protein kinase B-raf Homo sapiens 31 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165868&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127045769 341097719 CHEMBL3800081 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493263 Fc1ccc(NS(=O)(=O)c2cn[nH]c2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C19H13F2N9O2S/c20-12-3-4-13(30-33(31,32)10-6-27-28-7-10)14(21)16(12)29-18-11(2-1-5-22-18)15-17-19(25-8-23-15)26-9-24-17/h1-9,30H,(H,22,29)(H,27,28)(H,23,24,25,26) ZFTVIODRJLZDMA-UHFFFAOYSA-N 50165870 CHEMBL3797403 Serine/threonine-protein kinase B-raf Homo sapiens 6.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165870&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127045770 341097720 CHEMBL3797403 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493264 Cn1cc(cn1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H15F2N9O2S/c1-31-8-11(7-28-31)34(32,33)30-14-5-4-13(21)17(15(14)22)29-19-12(3-2-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h2-10,30H,1H3,(H,23,29)(H,24,25,26,27) MFGDWGYOUFSTFA-UHFFFAOYSA-N 197714 US9216981, 43 Serine/threonine-protein kinase B-raf Homo sapiens 710 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197714&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343972 318488831 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493265 CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C17H13F2N7O2S/c1-29(27,28)26-11-5-4-10(18)14(12(11)19)25-16-9(3-2-6-20-16)13-15-17(23-7-21-13)24-8-22-15/h2-8,26H,1H3,(H,20,25)(H,21,22,23,24) WCNKFDYACPTVPO-UHFFFAOYSA-N 50165871 CHEMBL3798635::US9550781, 13 Serine/threonine-protein kinase B-raf Homo sapiens 356 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165871&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71570573 341097721 CHEMBL3798635 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493266 CCCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H17F2N7O2S/c1-2-8-31(29,30)28-13-6-5-12(20)16(14(13)21)27-18-11(4-3-7-22-18)15-17-19(25-9-23-15)26-10-24-17/h3-7,9-10,28H,2,8H2,1H3,(H,22,27)(H,23,24,25,26) ZCFRMOFRDWXLRB-UHFFFAOYSA-N 197677 US9216981, 5::US9550781, 1 Serine/threonine-protein kinase B-raf Homo sapiens 24 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197677&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344795 318488794 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493267 Fc1ccc(NS(=O)(=O)CC(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C18H12F5N7O2S/c19-10-3-4-11(30-33(31,32)6-18(21,22)23)12(20)14(10)29-16-9(2-1-5-24-16)13-15-17(27-7-25-13)28-8-26-15/h1-5,7-8,30H,6H2,(H,24,29)(H,25,26,27,28) PWEHFDUGZVTNNL-UHFFFAOYSA-N 50165873 CHEMBL3800014::US9550781, 19 Serine/threonine-protein kinase B-raf Homo sapiens 40 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165873&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71570722 341097722 CHEMBL3800014 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493268 CC(C)CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H19F2N7O2S/c1-11(2)8-32(30,31)29-14-6-5-13(21)17(15(14)22)28-19-12(4-3-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h3-7,9-11,29H,8H2,1-2H3,(H,23,28)(H,24,25,26,27) QWFFFUZGWWOIMW-UHFFFAOYSA-N 50165874 CHEMBL3799488 Serine/threonine-protein kinase B-raf Homo sapiens 17 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165874&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046445 341097723 CHEMBL3799488 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493269 Fc1ccc(NS(=O)(=O)CC2CC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H17F2N7O2S/c21-13-5-6-14(29-32(30,31)8-11-3-4-11)15(22)17(13)28-19-12(2-1-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-2,5-7,9-11,29H,3-4,8H2,(H,23,28)(H,24,25,26,27) YPINALOZMFRIOO-UHFFFAOYSA-N 50165875 CHEMBL3798570 Serine/threonine-protein kinase B-raf Homo sapiens 33 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165875&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046446 341097724 CHEMBL3798570 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493270 CC(C)(C)CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C21H21F2N7O2S/c1-21(2,3)9-33(31,32)30-14-7-6-13(22)17(15(14)23)29-19-12(5-4-8-24-19)16-18-20(27-10-25-16)28-11-26-18/h4-8,10-11,30H,9H2,1-3H3,(H,24,29)(H,25,26,27,28) SMQPPWBGDWYCFJ-UHFFFAOYSA-N 50165856 CHEMBL3799342 Serine/threonine-protein kinase B-raf Homo sapiens 63 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165856&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046615 104051354 CHEMBL3799342 ZINC28524535 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493271 Fc1ccc(NS(=O)(=O)Cc2ccccc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C23H17F2N7O2S/c24-16-8-9-17(32-35(33,34)11-14-5-2-1-3-6-14)18(25)20(16)31-22-15(7-4-10-26-22)19-21-23(29-12-27-19)30-13-28-21/h1-10,12-13,32H,11H2,(H,26,31)(H,27,28,29,30) KXZXQWZNHDHQET-UHFFFAOYSA-N 50165857 CHEMBL3800157 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165857&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047893 104051355 CHEMBL3800157 ZINC28522120 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493272 CC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H17F2N7O2S/c1-10(2)31(29,30)28-13-6-5-12(20)16(14(13)21)27-18-11(4-3-7-22-18)15-17-19(25-8-23-15)26-9-24-17/h3-10,28H,1-2H3,(H,22,27)(H,23,24,25,26) LJGJKSMJLUENHX-UHFFFAOYSA-N 197673 US9216981, 1 Serine/threonine-protein kinase B-raf Homo sapiens 45 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344791 318488790 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493273 CCC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H19F2N7O2S/c1-3-11(2)32(30,31)29-14-7-6-13(21)17(15(14)22)28-19-12(5-4-8-23-19)16-18-20(26-9-24-16)27-10-25-18/h4-11,29H,3H2,1-2H3,(H,23,28)(H,24,25,26,27) XMFJRQPXMQXCTL-UHFFFAOYSA-N 50165858 CHEMBL3800227 Serine/threonine-protein kinase B-raf Homo sapiens 27 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165858&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048021 341097711 CHEMBL3800227 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493274 CCCC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C21H21F2N7O2S/c1-3-5-12(2)33(31,32)30-15-8-7-14(22)18(16(15)23)29-20-13(6-4-9-24-20)17-19-21(27-10-25-17)28-11-26-19/h4,6-12,30H,3,5H2,1-2H3,(H,24,29)(H,25,26,27,28) KASOTWCGKVLVEN-UHFFFAOYSA-N 50165859 CHEMBL3799288 Serine/threonine-protein kinase B-raf Homo sapiens 130 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165859&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048022 341097712 CHEMBL3799288 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493275 Fc1ccc(NS(=O)(=O)C2CC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C19H15F2N7O2S/c20-12-5-6-13(28-31(29,30)10-3-4-10)14(21)16(12)27-18-11(2-1-7-22-18)15-17-19(25-8-23-15)26-9-24-17/h1-2,5-10,28H,3-4H2,(H,22,27)(H,23,24,25,26) SMMQTLKZQUWOFV-UHFFFAOYSA-N 197690 US9216981, 19 Serine/threonine-protein kinase B-raf Homo sapiens 173 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197690&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345095 318488807 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493276 Fc1ccc(NS(=O)(=O)C2CCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H17F2N7O2S/c21-13-6-7-14(29-32(30,31)11-3-1-4-11)15(22)17(13)28-19-12(5-2-8-23-19)16-18-20(26-9-24-16)27-10-25-18/h2,5-11,29H,1,3-4H2,(H,23,28)(H,24,25,26,27) JONADRDDUBKXHN-UHFFFAOYSA-N 50165860 CHEMBL3798630 Serine/threonine-protein kinase B-raf Homo sapiens 41 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165860&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048023 341097713 CHEMBL3798630 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493277 Fc1ccc(NS(=O)(=O)C2CCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H19F2N7O2S/c22-14-7-8-15(30-33(31,32)12-4-1-2-5-12)16(23)18(14)29-20-13(6-3-9-24-20)17-19-21(27-10-25-17)28-11-26-19/h3,6-12,30H,1-2,4-5H2,(H,24,29)(H,25,26,27,28) JYFROOXDYMGYMV-UHFFFAOYSA-N 50165876 CHEMBL3800364 Serine/threonine-protein kinase B-raf Homo sapiens 11 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165876&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047243 341097725 CHEMBL3800364 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493278 Fc1ccc(NS(=O)(=O)C2CCOC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H17F2N7O3S/c21-13-3-4-14(29-33(30,31)11-5-7-32-8-11)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-4,6,9-11,29H,5,7-8H2,(H,23,28)(H,24,25,26,27) FVFZJRXMBNFYKM-UHFFFAOYSA-N 50165878 CHEMBL3798235 Serine/threonine-protein kinase B-raf Homo sapiens 31 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165878&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047244 341097726 CHEMBL3798235 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493279 Fc1ccc(NS(=O)(=O)C2CCCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H21F2N7O2S/c23-15-8-9-16(31-34(32,33)13-5-2-1-3-6-13)17(24)19(15)30-21-14(7-4-10-25-21)18-20-22(28-11-26-18)29-12-27-20/h4,7-13,31H,1-3,5-6H2,(H,25,30)(H,26,27,28,29) HELVMFLMFAYVHW-UHFFFAOYSA-N 197683 US9216981, 11 Serine/threonine-protein kinase B-raf Homo sapiens 40 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197683&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344993 318488800 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493280 Fc1ccc(NS(=O)(=O)C2CCOCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H19F2N7O3S/c22-14-3-4-15(30-34(31,32)12-5-8-33-9-6-12)16(23)18(14)29-20-13(2-1-7-24-20)17-19-21(27-10-25-17)28-11-26-19/h1-4,7,10-12,30H,5-6,8-9H2,(H,24,29)(H,25,26,27,28) STVYRNAAKPYOJY-UHFFFAOYSA-N 50165879 CHEMBL3798516 Serine/threonine-protein kinase B-raf Homo sapiens 356 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165879&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047245 341097727 CHEMBL3798516 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493281 CN(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C18H16F2N8O2S/c1-28(2)31(29,30)27-12-6-5-11(19)15(13(12)20)26-17-10(4-3-7-21-17)14-16-18(24-8-22-14)25-9-23-16/h3-9,27H,1-2H3,(H,21,26)(H,22,23,24,25) DFMZBEXLPWVTSV-UHFFFAOYSA-N 50165880 CHEMBL3798256 Serine/threonine-protein kinase B-raf Homo sapiens 54 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165880&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118988423 341097728 CHEMBL3798256 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493282 CCN(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H18F2N8O2S/c1-3-29(2)32(30,31)28-13-7-6-12(20)16(14(13)21)27-18-11(5-4-8-22-18)15-17-19(25-9-23-15)26-10-24-17/h4-10,28H,3H2,1-2H3,(H,22,27)(H,23,24,25,26) AFSMOIAGUMMQNG-UHFFFAOYSA-N 50165881 CHEMBL3797223 Serine/threonine-protein kinase B-raf Homo sapiens 87 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165881&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047246 341097729 CHEMBL3797223 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493283 CCN(CC)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H20F2N8O2S/c1-3-30(4-2)33(31,32)29-14-8-7-13(21)17(15(14)22)28-19-12(6-5-9-23-19)16-18-20(26-10-24-16)27-11-25-18/h5-11,29H,3-4H2,1-2H3,(H,23,28)(H,24,25,26,27) QKCAIQUAPOMAIJ-UHFFFAOYSA-N 50165883 CHEMBL3797353 Serine/threonine-protein kinase B-raf Homo sapiens 603 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165883&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046079 341097730 CHEMBL3797353 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493284 Fc1ccc(NS(=O)(=O)N2CCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H18F2N8O2S/c21-13-5-6-14(29-33(31,32)30-8-1-2-9-30)15(22)17(13)28-19-12(4-3-7-23-19)16-18-20(26-10-24-16)27-11-25-18/h3-7,10-11,29H,1-2,8-9H2,(H,23,28)(H,24,25,26,27) KBAJWXYBQYEMSD-UHFFFAOYSA-N 50165884 CHEMBL3799949 Serine/threonine-protein kinase B-raf Homo sapiens 44 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165884&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046080 341097731 CHEMBL3799949 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493285 Fc1ccc(NS(=O)(=O)N2CCCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H20F2N8O2S/c22-14-6-7-15(30-34(32,33)31-9-2-1-3-10-31)16(23)18(14)29-20-13(5-4-8-24-20)17-19-21(27-11-25-17)28-12-26-19/h4-8,11-12,30H,1-3,9-10H2,(H,24,29)(H,25,26,27,28) IZHJQYWDFVOZBF-UHFFFAOYSA-N 50165885 CHEMBL3798505 Serine/threonine-protein kinase B-raf Homo sapiens 65 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165885&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046081 341097732 CHEMBL3798505 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500626 CCOc1cc2ncnc(Nc3cc(ccc3OCC(F)(F)F)S(=O)(=O)NC)c2cc1OC InChI=1S/C20H21F3N4O5S/c1-4-31-18-9-14-13(8-17(18)30-3)19(26-11-25-14)27-15-7-12(33(28,29)24-2)5-6-16(15)32-10-20(21,22)23/h5-9,11,24H,4,10H2,1-3H3,(H,25,26,27) FFLPSTMYRDDWDO-UHFFFAOYSA-N 50178306 CHEMBL3814998 Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178306&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52932689 346549416 CHEMBL3814998 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500627 CNS(=O)(=O)c1ccc(OCC(F)(F)F)c(Nc2ncnc3cc(OC(C)C)c(OC)cc23)c1 InChI=1S/C21H23F3N4O5S/c1-12(2)33-19-9-15-14(8-18(19)31-4)20(27-11-26-15)28-16-7-13(34(29,30)25-3)5-6-17(16)32-10-21(22,23)24/h5-9,11-12,25H,10H2,1-4H3,(H,26,27,28) PNEYRCXCZRJLTK-UHFFFAOYSA-N 50178307 CHEMBL3814685 Serine/threonine-protein kinase B-raf Homo sapiens 32000 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178307&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52932691 346549417 CHEMBL3814685 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500628 CNS(=O)(=O)c1ccc(OCC(F)(F)F)c(Nc2ncnc3cc(OCCCOC)ccc23)c1 InChI=1S/C21H23F3N4O5S/c1-25-34(29,30)15-5-7-19(33-12-21(22,23)24)18(11-15)28-20-16-6-4-14(32-9-3-8-31-2)10-17(16)26-13-27-20/h4-7,10-11,13,25H,3,8-9,12H2,1-2H3,(H,26,27,28) TUINBAPNAKPWHO-UHFFFAOYSA-N 50178308 CHEMBL3814442 Serine/threonine-protein kinase B-raf Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178308&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52932914 346549418 CHEMBL3814442 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500629 CNS(=O)(=O)c1ccc(OCC(F)(F)F)c(Nc2ncnc3cc(OCCCN4CCOCC4)ccc23)c1 InChI=1S/C24H28F3N5O5S/c1-28-38(33,34)18-4-6-22(37-15-24(25,26)27)21(14-18)31-23-19-5-3-17(13-20(19)29-16-30-23)36-10-2-7-32-8-11-35-12-9-32/h3-6,13-14,16,28H,2,7-12,15H2,1H3,(H,29,30,31) BCPFKHJCHDHGPM-UHFFFAOYSA-N 50178309 CHEMBL3813957 Serine/threonine-protein kinase B-raf Homo sapiens 1300 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178309&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52932692 346549419 CHEMBL3813957 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500675 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]ccc23)c1 InChI=1S/C15H18N6O2S/c1-16-24(22,23)10-4-5-13(21(2)3)12(8-10)20-15-11-6-7-17-14(11)18-9-19-15/h4-9,16H,1-3H3,(H2,17,18,19,20) FRRDBCZMMUBGNF-UHFFFAOYSA-N 50118379 CHEMBL3613195 Serine/threonine-protein kinase B-raf Homo sapiens 6.0 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118379&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70648666 104011697 CHEMBL3613195 ZINC13491207 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500676 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3cc(OC)c(OC)cc23)c1 InChI=1S/C19H23N5O4S/c1-20-29(25,26)12-6-7-16(24(2)3)15(8-12)23-19-13-9-17(27-4)18(28-5)10-14(13)21-11-22-19/h6-11,20H,1-5H3,(H,21,22,23) YUSROMRPOFFTMX-UHFFFAOYSA-N 50178310 CHEMBL3815093 Serine/threonine-protein kinase B-raf Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178310&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52933152 346549420 CHEMBL3815093 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500677 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]ccc23)c1 InChI=1S/C13H13N5O2S/c1-14-21(19,20)10-4-2-3-9(7-10)18-13-11-5-6-15-12(11)16-8-17-13/h2-8,14H,1H3,(H2,15,16,17,18) OOBRVBGRWPCKGK-UHFFFAOYSA-N 50118396 CHEMBL3612647 Serine/threonine-protein kinase B-raf Homo sapiens 50 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118396&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67995854 104011714 CHEMBL3612647 ZINC13491186 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500678 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(C)c23)c1 InChI=1S/C14H15N5O2S/c1-9-7-16-13-12(9)14(18-8-17-13)19-10-4-3-5-11(6-10)22(20,21)15-2/h3-8,15H,1-2H3,(H2,16,17,18,19) BLOGYXPMEFIABI-UHFFFAOYSA-N 50118411 CHEMBL3612661 Serine/threonine-protein kinase B-raf Homo sapiens 63 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118411&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67995742 104011729 CHEMBL3612661 ZINC96300787 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500679 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(F)c23)c1 InChI=1S/C13H12FN5O2S/c1-15-22(20,21)9-4-2-3-8(5-9)19-13-11-10(14)6-16-12(11)17-7-18-13/h2-7,15H,1H3,(H2,16,17,18,19) BROIYLJWUMQYQV-UHFFFAOYSA-N 50118415 CHEMBL3612664 Serine/threonine-protein kinase B-raf Homo sapiens 79 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118415&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67996103 104011733 CHEMBL3612664 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500680 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(Cl)c23)c1 InChI=1S/C13H12ClN5O2S/c1-15-22(20,21)9-4-2-3-8(5-9)19-13-11-10(14)6-16-12(11)17-7-18-13/h2-7,15H,1H3,(H2,16,17,18,19) MCLHLDXITKQYFX-UHFFFAOYSA-N 50118416 CHEMBL3612665 Serine/threonine-protein kinase B-raf Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118416&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67995947 104011734 CHEMBL3612665 ZINC96300796 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500681 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(Br)c23)c1 InChI=1S/C13H12BrN5O2S/c1-15-22(20,21)9-4-2-3-8(5-9)19-13-11-10(14)6-16-12(11)17-7-18-13/h2-7,15H,1H3,(H2,16,17,18,19) KVTPQZZMIHGOTJ-UHFFFAOYSA-N 50118417 CHEMBL3612666 Serine/threonine-protein kinase B-raf Homo sapiens 5.0 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118417&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67996004 104011735 CHEMBL3612666 ZINC96300800 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500682 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4ccccc4)c23)c1 InChI=1S/C19H17N5O2S/c1-20-27(25,26)15-9-5-8-14(10-15)24-19-17-16(13-6-3-2-4-7-13)11-21-18(17)22-12-23-19/h2-12,20H,1H3,(H2,21,22,23,24) UCBHSPGNEZCSHN-UHFFFAOYSA-N 50118418 CHEMBL3612667 Serine/threonine-protein kinase B-raf Homo sapiens 4.0 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118418&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 67996588 104011736 CHEMBL3612667 ZINC37858407 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500683 CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4cccc(Cl)c4)c23)c1 InChI=1S/C19H16ClN5O2S/c1-21-28(26,27)15-7-3-6-14(9-15)25-19-17-16(10-22-18(17)23-11-24-19)12-4-2-5-13(20)8-12/h2-11,21H,1H3,(H2,22,23,24,25) APTZOLCMZQNBAH-UHFFFAOYSA-N 50118420 CHEMBL3613177 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118420&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70648685 104011738 CHEMBL3613177 ZINC37858409 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500684 CNS(=O)(=O)c1ccc(N2CCOCC2)c(Nc2ncnc3[nH]cc(Br)c23)c1 InChI=1S/C17H19BrN6O3S/c1-19-28(25,26)11-2-3-14(24-4-6-27-7-5-24)13(8-11)23-17-15-12(18)9-20-16(15)21-10-22-17/h2-3,8-10,19H,4-7H2,1H3,(H2,20,21,22,23) IMXJHHQPHUBYBA-UHFFFAOYSA-N 50118384 CHEMBL3613305 Serine/threonine-protein kinase B-raf Homo sapiens 0.500000 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118384&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 4CV 4YFF 70648683 104011702 CHEMBL3613305 ZINC01933195 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500685 CNS(=O)(=O)c1ccc(N2CCOCC2)c(Nc2ncnc3[nH]cc(Cl)c23)c1 InChI=1S/C17H19ClN6O3S/c1-19-28(25,26)11-2-3-14(24-4-6-27-7-5-24)13(8-11)23-17-15-12(18)9-20-16(15)21-10-22-17/h2-3,8-10,19H,4-7H2,1H3,(H2,20,21,22,23) LINMNMJCBXXKNC-UHFFFAOYSA-N 50178344 CHEMBL3814798 Serine/threonine-protein kinase B-raf Homo sapiens 0.600000 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178344&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 4EF 4YHT 70649546 104063673 CHEMBL3814798 ZINC28568435 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500686 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3ccccc23)c1 InChI=1S/C17H19N5O2S/c1-18-25(23,24)12-8-9-16(22(2)3)15(10-12)21-17-13-6-4-5-7-14(13)19-11-20-17/h4-11,18H,1-3H3,(H,19,20,21) GXUZZZRWJPJLHA-UHFFFAOYSA-N 50178345 CHEMBL3814179 Serine/threonine-protein kinase B-raf Homo sapiens 250 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178345&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52934796 104063674 CHEMBL3814179 ZINC28568280 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500687 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3ccsc23)c1 InChI=1S/C15H17N5O2S2/c1-16-24(21,22)10-4-5-13(20(2)3)12(8-10)19-15-14-11(6-7-23-14)17-9-18-15/h4-9,16H,1-3H3,(H,17,18,19) WTUQKICTFCBUOL-UHFFFAOYSA-N 50178346 CHEMBL3814515 Serine/threonine-protein kinase B-raf Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178346&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127051137 104063675 CHEMBL3814515 ZINC28568090 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500688 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3ccn(C)c23)c1 InChI=1S/C16H20N6O2S/c1-17-25(23,24)11-5-6-14(21(2)3)13(9-11)20-16-15-12(18-10-19-16)7-8-22(15)4/h5-10,17H,1-4H3,(H,18,19,20) NYCXATWLUSZHMH-UHFFFAOYSA-N 50178311 CHEMBL3814010 Serine/threonine-protein kinase B-raf Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178311&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127052416 346549421 CHEMBL3814010 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493286 O[C@H]1CCN(C1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H18F2N8O3S/c21-13-3-4-14(29-34(32,33)30-7-5-11(31)8-30)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-4,6,9-11,29,31H,5,7-8H2,(H,23,28)(H,24,25,26,27)/t11-/m0/s1 ZHQDXUJBHCRZBE-NSHDSACASA-N 50165886 CHEMBL3800002 Serine/threonine-protein kinase B-raf Homo sapiens 201 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165886&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046082 341097733 CHEMBL3800002 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493287 O[C@@H]1CCN(C1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H18F2N8O3S/c21-13-3-4-14(29-34(32,33)30-7-5-11(31)8-30)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-4,6,9-11,29,31H,5,7-8H2,(H,23,28)(H,24,25,26,27)/t11-/m1/s1 ZHQDXUJBHCRZBE-LLVKDONJSA-N 50165887 CHEMBL3797494 Serine/threonine-protein kinase B-raf Homo sapiens 233 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165887&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046289 341097734 CHEMBL3797494 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493288 Fc1ccc(NS(=O)(=O)N2CCOCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H18F2N8O3S/c21-13-3-4-14(29-34(31,32)30-6-8-33-9-7-30)15(22)17(13)28-19-12(2-1-5-23-19)16-18-20(26-10-24-16)27-11-25-18/h1-5,10-11,29H,6-9H2,(H,23,28)(H,24,25,26,27) PVLBWLQBZCGLQR-UHFFFAOYSA-N 197692 US9216981, 21 Serine/threonine-protein kinase B-raf Homo sapiens 293 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197692&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345097 318488809 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493289 Fc1ccc(NS(=O)(=O)N2CCNCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H19F2N9O2S/c21-13-3-4-14(30-34(32,33)31-8-6-23-7-9-31)15(22)17(13)29-19-12(2-1-5-24-19)16-18-20(27-10-25-16)28-11-26-18/h1-5,10-11,23,30H,6-9H2,(H,24,29)(H,25,26,27,28) INHDDMDMADEERR-UHFFFAOYSA-N 50165888 CHEMBL3799046 Serine/threonine-protein kinase B-raf Homo sapiens 1000 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165888&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047676 341097735 CHEMBL3799046 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493290 Fc1ccc(NS(=O)(=O)C2CCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H19F2N7O2S/c22-14-7-8-15(30-33(31,32)12-4-1-2-5-12)16(23)18(14)29-20-13(6-3-9-24-20)17-19-21(27-10-25-17)28-11-26-19/h3,6-12,30H,1-2,4-5H2,(H,24,29)(H,25,26,27,28) JYFROOXDYMGYMV-UHFFFAOYSA-N 50165876 CHEMBL3800364 Serine/threonine-protein kinase B-raf Homo sapiens 2.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165876&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047243 341097725 CHEMBL3800364 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493291 Fc1ccc(NS(=O)(=O)C2CCOC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H17F2N7O3S/c21-13-3-4-14(29-33(30,31)11-5-7-32-8-11)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-4,6,9-11,29H,5,7-8H2,(H,23,28)(H,24,25,26,27) FVFZJRXMBNFYKM-UHFFFAOYSA-N 50165878 CHEMBL3798235 Serine/threonine-protein kinase B-raf Homo sapiens 5.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165878&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047244 341097726 CHEMBL3798235 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493292 Fc1ccc(NS(=O)(=O)C2CCCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H21F2N7O2S/c23-15-8-9-16(31-34(32,33)13-5-2-1-3-6-13)17(24)19(15)30-21-14(7-4-10-25-21)18-20-22(28-11-26-18)29-12-27-20/h4,7-13,31H,1-3,5-6H2,(H,25,30)(H,26,27,28,29) HELVMFLMFAYVHW-UHFFFAOYSA-N 197683 US9216981, 11 Serine/threonine-protein kinase B-raf Homo sapiens 18 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197683&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344993 318488800 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493293 Fc1ccc(NS(=O)(=O)C2CCOCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H19F2N7O3S/c22-14-3-4-15(30-34(31,32)12-5-8-33-9-6-12)16(23)18(14)29-20-13(2-1-7-24-20)17-19-21(27-10-25-17)28-11-26-19/h1-4,7,10-12,30H,5-6,8-9H2,(H,24,29)(H,25,26,27,28) STVYRNAAKPYOJY-UHFFFAOYSA-N 50165879 CHEMBL3798516 Serine/threonine-protein kinase B-raf Homo sapiens 31 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165879&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047245 341097727 CHEMBL3798516 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493294 CN(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C18H16F2N8O2S/c1-28(2)31(29,30)27-12-6-5-11(19)15(13(12)20)26-17-10(4-3-7-21-17)14-16-18(24-8-22-14)25-9-23-16/h3-9,27H,1-2H3,(H,21,26)(H,22,23,24,25) DFMZBEXLPWVTSV-UHFFFAOYSA-N 50165880 CHEMBL3798256 Serine/threonine-protein kinase B-raf Homo sapiens 8.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165880&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118988423 341097728 CHEMBL3798256 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493295 Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C26H19ClN8/c1-15-4-9-19-18(10-12-29-24(19)34-17-7-5-16(27)6-8-17)21(15)35-25-20(3-2-11-28-25)22-23-26(32-13-30-22)33-14-31-23/h2-14H,1H3,(H,28,35)(H,29,34)(H,30,31,32,33) KKVYYGGCHJGEFJ-UHFFFAOYSA-N 50165861 CHEMBL1197798 Serine/threonine-protein kinase B-raf Homo sapiens 2.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165861&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44223999 341097714 CHEMBL1197798 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493296 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 4.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493297 CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29) BFSMGDJOXZAERB-UHFFFAOYSA-N 50428286 DABRAFENIB::GSK2118436A Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50428286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50428286&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search P06 7RIV,4XV2,5CSW,6HJ2,6V2U,5HIE 44462760 164157161 75045 DB08912 ZINC68153186 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493298 Fc1ccc(NS(=O)(=O)c2ccccc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H15F2N7O2S/c23-15-8-9-16(31-34(32,33)13-5-2-1-3-6-13)17(24)19(15)30-21-14(7-4-10-25-21)18-20-22(28-11-26-18)29-12-27-20/h1-12,31H,(H,25,30)(H,26,27,28,29) UHPAFPKCOMSYMO-UHFFFAOYSA-N 197706 US9216981, 35::US9550781, 15 Serine/threonine-protein kinase B-raf Homo sapiens 7.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197706&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343766 318488823 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493299 Fc1ccc(NS(=O)(=O)c2ccccc2F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C22H14F3N7O2S/c23-13-5-1-2-6-16(13)35(33,34)32-15-8-7-14(24)19(17(15)25)31-21-12(4-3-9-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) ILBNLHRNSBVYOE-UHFFFAOYSA-N 50165863 CHEMBL3800226 Serine/threonine-protein kinase B-raf Homo sapiens 3.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165863&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047050 341097715 CHEMBL3800226 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493300 Fc1cccc(c1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H14F3N7O2S/c23-12-3-1-4-13(9-12)35(33,34)32-16-7-6-15(24)19(17(16)25)31-21-14(5-2-8-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) NAMHUPSTGXJBQO-UHFFFAOYSA-N 50165864 CHEMBL3799014 Serine/threonine-protein kinase B-raf Homo sapiens 3.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165864&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047051 341097716 CHEMBL3799014 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493301 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C22H14F3N7O2S/c23-12-3-5-13(6-4-12)35(33,34)32-16-8-7-15(24)19(17(16)25)31-21-14(2-1-9-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30) HWTHWPBGOLUDQA-UHFFFAOYSA-N 50165865 CHEMBL3798423::US9550781, 23 Serine/threonine-protein kinase B-raf Homo sapiens 36 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165865&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71570866 341097717 CHEMBL3798423 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493302 Fc1ccc(NS(=O)(=O)c2cccnc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H14F2N8O2S/c22-14-5-6-15(31-34(32,33)12-3-1-7-24-9-12)16(23)18(14)30-20-13(4-2-8-25-20)17-19-21(28-10-26-17)29-11-27-19/h1-11,31H,(H,25,30)(H,26,27,28,29) JTESGLUEGOKQOX-UHFFFAOYSA-N 197701 US9216981, 30 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197701&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345328 318488818 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493303 Fc1ccc(NS(=O)(=O)c2ccccn2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H14F2N8O2S/c22-13-6-7-14(31-34(32,33)15-5-1-2-8-24-15)16(23)18(13)30-20-12(4-3-9-25-20)17-19-21(28-10-26-17)29-11-27-19/h1-11,31H,(H,25,30)(H,26,27,28,29) AVXOLCIHZKRJSD-UHFFFAOYSA-N 50165866 CHEMBL3799483 Serine/threonine-protein kinase B-raf Homo sapiens 21 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165866&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127045991 341097718 CHEMBL3799483 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493304 Fc1ccc(NS(=O)(=O)c2cccs2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H13F2N7O2S2/c21-12-5-6-13(29-33(30,31)14-4-2-8-32-14)15(22)17(12)28-19-11(3-1-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-10,29H,(H,23,28)(H,24,25,26,27) AUPADWFQWOIWBW-UHFFFAOYSA-N 197676 US9216981, 4 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197676&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344794 318488793 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493305 Fc1ccc(NS(=O)(=O)c2nccs2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C19H12F2N8O2S2/c20-11-3-4-12(29-33(30,31)19-23-6-7-32-19)13(21)15(11)28-17-10(2-1-5-22-17)14-16-18(26-8-24-14)27-9-25-16/h1-9,29H,(H,22,28)(H,24,25,26,27) XKEIGURBFSAWSQ-UHFFFAOYSA-N 50165868 CHEMBL3800081 Serine/threonine-protein kinase B-raf Homo sapiens 1.000000 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165868&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127045769 341097719 CHEMBL3800081 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493306 Fc1ccc(NS(=O)(=O)c2cn[nH]c2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C19H13F2N9O2S/c20-12-3-4-13(30-33(31,32)10-6-27-28-7-10)14(21)16(12)29-18-11(2-1-5-22-18)15-17-19(25-8-23-15)26-9-24-17/h1-9,30H,(H,22,29)(H,27,28)(H,23,24,25,26) ZFTVIODRJLZDMA-UHFFFAOYSA-N 50165870 CHEMBL3797403 Serine/threonine-protein kinase B-raf Homo sapiens 0.200000 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165870&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127045770 341097720 CHEMBL3797403 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493307 Cn1cc(cn1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H15F2N9O2S/c1-31-8-11(7-28-31)34(32,33)30-14-5-4-13(21)17(15(14)22)29-19-12(3-2-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h2-10,30H,1H3,(H,23,29)(H,24,25,26,27) MFGDWGYOUFSTFA-UHFFFAOYSA-N 197714 US9216981, 43 Serine/threonine-protein kinase B-raf Homo sapiens 8.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197714&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343972 318488831 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493308 Cc1n[nH]c(C)c1S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C21H17F2N9O2S/c1-10-19(11(2)31-30-10)35(33,34)32-14-6-5-13(22)17(15(14)23)29-20-12(4-3-7-24-20)16-18-21(27-8-25-16)28-9-26-18/h3-9,32H,1-2H3,(H,24,29)(H,30,31)(H,25,26,27,28) GOZZYNGIYPRQOB-UHFFFAOYSA-N 50165855 CHEMBL3800378 Serine/threonine-protein kinase B-raf Homo sapiens 216 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165855&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127045771 104051353 CHEMBL3800378 ZINC28524373 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493309 CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C17H13F2N7O2S/c1-29(27,28)26-11-5-4-10(18)14(12(11)19)25-16-9(3-2-6-20-16)13-15-17(23-7-21-13)24-8-22-15/h2-8,26H,1H3,(H,20,25)(H,21,22,23,24) WCNKFDYACPTVPO-UHFFFAOYSA-N 50165871 CHEMBL3798635::US9550781, 13 Serine/threonine-protein kinase B-raf Homo sapiens 360 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165871&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71570573 341097721 CHEMBL3798635 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493310 CCCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H17F2N7O2S/c1-2-8-31(29,30)28-13-6-5-12(20)16(14(13)21)27-18-11(4-3-7-22-18)15-17-19(25-9-23-15)26-10-24-17/h3-7,9-10,28H,2,8H2,1H3,(H,22,27)(H,23,24,25,26) ZCFRMOFRDWXLRB-UHFFFAOYSA-N 197677 US9216981, 5::US9550781, 1 Serine/threonine-protein kinase B-raf Homo sapiens 9.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197677&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57344795 318488794 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493311 Fc1ccc(NS(=O)(=O)CC(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C18H12F5N7O2S/c19-10-3-4-11(30-33(31,32)6-18(21,22)23)12(20)14(10)29-16-9(2-1-5-24-16)13-15-17(27-7-25-13)28-8-26-15/h1-5,7-8,30H,6H2,(H,24,29)(H,25,26,27,28) PWEHFDUGZVTNNL-UHFFFAOYSA-N 50165873 CHEMBL3800014::US9550781, 19 Serine/threonine-protein kinase B-raf Homo sapiens 3.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165873&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 71570722 341097722 CHEMBL3800014 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493312 CC(C)CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H19F2N7O2S/c1-11(2)8-32(30,31)29-14-6-5-13(21)17(15(14)22)28-19-12(4-3-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h3-7,9-11,29H,8H2,1-2H3,(H,23,28)(H,24,25,26,27) QWFFFUZGWWOIMW-UHFFFAOYSA-N 50165874 CHEMBL3799488 Serine/threonine-protein kinase B-raf Homo sapiens 6.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165874&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046445 341097723 CHEMBL3799488 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493313 Fc1ccc(NS(=O)(=O)CC2CC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H17F2N7O2S/c21-13-5-6-14(29-32(30,31)8-11-3-4-11)15(22)17(13)28-19-12(2-1-7-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-2,5-7,9-11,29H,3-4,8H2,(H,23,28)(H,24,25,26,27) YPINALOZMFRIOO-UHFFFAOYSA-N 50165875 CHEMBL3798570 Serine/threonine-protein kinase B-raf Homo sapiens 8.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165875&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046446 341097724 CHEMBL3798570 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493314 CCN(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C19H18F2N8O2S/c1-3-29(2)32(30,31)28-13-7-6-12(20)16(14(13)21)27-18-11(5-4-8-22-18)15-17-19(25-9-23-15)26-10-24-17/h4-10,28H,3H2,1-2H3,(H,22,27)(H,23,24,25,26) AFSMOIAGUMMQNG-UHFFFAOYSA-N 50165881 CHEMBL3797223 Serine/threonine-protein kinase B-raf Homo sapiens 22 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165881&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127047246 341097729 CHEMBL3797223 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493315 CCN(CC)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H20F2N8O2S/c1-3-30(4-2)33(31,32)29-14-8-7-13(21)17(15(14)22)28-19-12(6-5-9-23-19)16-18-20(26-10-24-16)27-11-25-18/h5-11,29H,3-4H2,1-2H3,(H,23,28)(H,24,25,26,27) QKCAIQUAPOMAIJ-UHFFFAOYSA-N 50165883 CHEMBL3797353 Serine/threonine-protein kinase B-raf Homo sapiens 57 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165883&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046079 341097730 CHEMBL3797353 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493316 Fc1ccc(NS(=O)(=O)N2CCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H18F2N8O2S/c21-13-5-6-14(29-33(31,32)30-8-1-2-9-30)15(22)17(13)28-19-12(4-3-7-23-19)16-18-20(26-10-24-16)27-11-25-18/h3-7,10-11,29H,1-2,8-9H2,(H,23,28)(H,24,25,26,27) KBAJWXYBQYEMSD-UHFFFAOYSA-N 50165884 CHEMBL3799949 Serine/threonine-protein kinase B-raf Homo sapiens 2.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165884&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046080 341097731 CHEMBL3799949 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493317 Fc1ccc(NS(=O)(=O)N2CCCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C21H20F2N8O2S/c22-14-6-7-15(30-34(32,33)31-9-2-1-3-10-31)16(23)18(14)29-20-13(5-4-8-24-20)17-19-21(27-11-25-17)28-12-26-19/h4-8,11-12,30H,1-3,9-10H2,(H,24,29)(H,25,26,27,28) IZHJQYWDFVOZBF-UHFFFAOYSA-N 50165885 CHEMBL3798505 Serine/threonine-protein kinase B-raf Homo sapiens 15 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165885&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046081 341097732 CHEMBL3798505 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493318 O[C@H]1CCN(C1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H18F2N8O3S/c21-13-3-4-14(29-34(32,33)30-7-5-11(31)8-30)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-4,6,9-11,29,31H,5,7-8H2,(H,23,28)(H,24,25,26,27)/t11-/m0/s1 ZHQDXUJBHCRZBE-NSHDSACASA-N 50165886 CHEMBL3800002 Serine/threonine-protein kinase B-raf Homo sapiens 9.0 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165886&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046082 341097733 CHEMBL3800002 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493319 O[C@@H]1CCN(C1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F InChI=1S/C20H18F2N8O3S/c21-13-3-4-14(29-34(32,33)30-7-5-11(31)8-30)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-4,6,9-11,29,31H,5,7-8H2,(H,23,28)(H,24,25,26,27)/t11-/m1/s1 ZHQDXUJBHCRZBE-LLVKDONJSA-N 50165887 CHEMBL3797494 Serine/threonine-protein kinase B-raf Homo sapiens 16 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165887&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127046289 341097734 CHEMBL3797494 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50493320 Fc1ccc(NS(=O)(=O)N2CCOCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 InChI=1S/C20H18F2N8O3S/c21-13-3-4-14(29-34(31,32)30-6-8-33-9-7-30)15(22)17(13)28-19-12(2-1-5-23-19)16-18-20(26-10-24-16)27-11-25-18/h1-5,10-11,29H,6-9H2,(H,23,28)(H,24,25,26,27) PVLBWLQBZCGLQR-UHFFFAOYSA-N 197692 US9216981, 21 Serine/threonine-protein kinase B-raf Homo sapiens 62 ChEMBL 10.1016/j.bmc.2016.03.055 10.7270/Q21C1ZS0 27085672 Liu, L; Lee, MR; Kim, JL; Whittington, DA; Bregman, H; Hua, Z; Lewis, RT; Martin, MW; Nishimura, N; Potashman, M; Yang, K; Yi, S; Vaida, KR; Epstein, LF; Babij, C; Fernando, M; Carnahan, J; Norman, MH Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=197692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=197692&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57345097 318488809 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500689 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3cc[nH]c23)c1 InChI=1S/C15H18N6O2S/c1-16-24(22,23)10-4-5-13(21(2)3)12(8-10)20-15-14-11(6-7-17-14)18-9-19-15/h4-9,16-17H,1-3H3,(H,18,19,20) WAOIOMNKIUTNHS-UHFFFAOYSA-N 50178312 CHEMBL3815116 Serine/threonine-protein kinase B-raf Homo sapiens 250 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178312&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127052706 346549422 CHEMBL3815116 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500690 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3ccc(OC)cc23)c1 InChI=1S/C18H21N5O3S/c1-19-27(24,25)13-6-8-17(23(2)3)16(10-13)22-18-14-9-12(26-4)5-7-15(14)20-11-21-18/h5-11,19H,1-4H3,(H,20,21,22) FFRWTFPJRTXJRL-UHFFFAOYSA-N 50178347 CHEMBL3813871 Serine/threonine-protein kinase B-raf Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178347&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52934573 104063676 CHEMBL3813871 ZINC28568468 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500691 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3ccc(N)cc23)c1 InChI=1S/C17H20N6O2S/c1-19-26(24,25)12-5-7-16(23(2)3)15(9-12)22-17-13-8-11(18)4-6-14(13)20-10-21-17/h4-10,19H,18H2,1-3H3,(H,20,21,22) OQHRVARQAYXXKB-UHFFFAOYSA-N 50178348 CHEMBL3814121 Serine/threonine-protein kinase B-raf Homo sapiens 630 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178348&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52932687 104063677 CHEMBL3814121 ZINC28568243 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500692 CNc1ccc2ncnc(Nc3cc(ccc3N(C)C)S(=O)(=O)NC)c2c1 InChI=1S/C18H22N6O2S/c1-19-12-5-7-15-14(9-12)18(22-11-21-15)23-16-10-13(27(25,26)20-2)6-8-17(16)24(3)4/h5-11,19-20H,1-4H3,(H,21,22,23) HSXXPAFGNVISQH-UHFFFAOYSA-N 50178349 CHEMBL3813902 Serine/threonine-protein kinase B-raf Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178349&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52936114 104063678 CHEMBL3813902 ZINC28568099 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500693 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3cc(N)ccc23)c1 InChI=1S/C17H20N6O2S/c1-19-26(24,25)12-5-7-16(23(2)3)15(9-12)22-17-13-6-4-11(18)8-14(13)20-10-21-17/h4-10,19H,18H2,1-3H3,(H,20,21,22) LVRXFIZRHGNOHR-UHFFFAOYSA-N 50178350 CHEMBL3814727 Serine/threonine-protein kinase B-raf Homo sapiens 4000 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178350&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52936117 104063679 CHEMBL3814727 ZINC28568458 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500694 CNc1ccc2c(Nc3cc(ccc3N(C)C)S(=O)(=O)NC)ncnc2c1 InChI=1S/C18H22N6O2S/c1-19-12-5-7-14-15(9-12)21-11-22-18(14)23-16-10-13(27(25,26)20-2)6-8-17(16)24(3)4/h5-11,19-20H,1-4H3,(H,21,22,23) GSRJICYGMFRKNT-UHFFFAOYSA-N 50178351 CHEMBL3813872 Serine/threonine-protein kinase B-raf Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178351&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52935028 104063680 CHEMBL3813872 ZINC28568173 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500695 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3cc(OCCCOC)ccc23)c1 InChI=1S/C21H27N5O4S/c1-22-31(27,28)16-7-9-20(26(2)3)19(13-16)25-21-17-8-6-15(30-11-5-10-29-4)12-18(17)23-14-24-21/h6-9,12-14,22H,5,10-11H2,1-4H3,(H,23,24,25) BWIUPWHYSIZHBS-UHFFFAOYSA-N 50178313 CHEMBL3814871 Serine/threonine-protein kinase B-raf Homo sapiens 800 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178313&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52932915 346549423 CHEMBL3814871 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500696 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3cc(OCCCN4CCOCC4)ccc23)c1 InChI=1S/C24H32N6O4S/c1-25-35(31,32)19-6-8-23(29(2)3)22(16-19)28-24-20-7-5-18(15-21(20)26-17-27-24)34-12-4-9-30-10-13-33-14-11-30/h5-8,15-17,25H,4,9-14H2,1-3H3,(H,26,27,28) QYAZLRALCQRFSU-UHFFFAOYSA-N 50178339 CHEMBL3814923 Serine/threonine-protein kinase B-raf Homo sapiens 2500 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178339&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52932917 104063668 CHEMBL3814923 ZINC28568140 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500697 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3cc(OC)cc(OC)c23)c1 InChI=1S/C19H23N5O4S/c1-20-29(25,26)13-6-7-16(24(2)3)14(10-13)23-19-18-15(21-11-22-19)8-12(27-4)9-17(18)28-5/h6-11,20H,1-5H3,(H,21,22,23) KFBXNJYHMZCVDH-UHFFFAOYSA-N 50178340 CHEMBL3814834 Serine/threonine-protein kinase B-raf Homo sapiens 79 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178340&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52933647 104063669 CHEMBL3814834 ZINC28568403 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500698 CNS(=O)(=O)c1ccc(OCC(F)(F)F)c(Nc2ncnc3cc(OC)c(OC)cc23)c1 InChI=1S/C19H19F3N4O5S/c1-23-32(27,28)11-4-5-15(31-9-19(20,21)22)14(6-11)26-18-12-7-16(29-2)17(30-3)8-13(12)24-10-25-18/h4-8,10,23H,9H2,1-3H3,(H,24,25,26) NRHLZORMVVHHTO-UHFFFAOYSA-N 50178341 CHEMBL3814635 Serine/threonine-protein kinase B-raf Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178341&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52934570 104063670 CHEMBL3814635 ZINC28568604 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500699 CNS(=O)(=O)c1ccc(OCC(F)(F)F)c(Nc2ncnc3cc(OC)cc(OC)c23)c1 InChI=1S/C19H19F3N4O5S/c1-23-32(27,28)12-4-5-15(31-9-19(20,21)22)13(8-12)26-18-17-14(24-10-25-18)6-11(29-2)7-16(17)30-3/h4-8,10,23H,9H2,1-3H3,(H,24,25,26) CBKNUIDRLNIWKI-UHFFFAOYSA-N 50178342 CHEMBL3813948 Serine/threonine-protein kinase B-raf Homo sapiens 50 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178342&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52934106 104063671 CHEMBL3813948 ZINC49937078 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50500700 CNS(=O)(=O)c1ccc(OCC(F)(F)F)c(Nc2ncnc3cc(OC)c(OC)c(OC)c23)c1 InChI=1S/C20H21F3N4O6S/c1-24-34(28,29)11-5-6-14(33-9-20(21,22)23)12(7-11)27-19-16-13(25-10-26-19)8-15(30-2)17(31-3)18(16)32-4/h5-8,10,24H,9H2,1-4H3,(H,25,26,27) POLFXEZBQNZFED-UHFFFAOYSA-N 50178343 CHEMBL3814097 Serine/threonine-protein kinase B-raf Homo sapiens 79 ChEMBL 10.1016/j.bmcl.2016.05.033 10.7270/Q27083BJ 27246618 Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178343&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52935890 104063672 CHEMBL3814097 ZINC28568177 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501208 CS(=O)(=O)Nc1cccc(Cn2c(=O)oc3cc(OC(=O)c4ccccc4)ccc3c2=O)c1F InChI=1S/C23H17FN2O7S/c1-34(30,31)25-18-9-5-8-15(20(18)24)13-26-21(27)17-11-10-16(12-19(17)33-23(26)29)32-22(28)14-6-3-2-4-7-14/h2-12,25H,13H2,1H3 HQMTYBQAVSAJOJ-UHFFFAOYSA-N 50179521 CHEMBL3814031 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179521&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127052124 346549593 CHEMBL3814031 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501209 COc1ccc2c(c1)oc(=O)n(Cc1cccc(NS(=O)(=O)NCCC#N)c1F)c2=O InChI=1S/C19H17FN4O6S/c1-29-13-6-7-14-16(10-13)30-19(26)24(18(14)25)11-12-4-2-5-15(17(12)20)23-31(27,28)22-9-3-8-21/h2,4-7,10,22-23H,3,9,11H2,1H3 AYAZLPMZEOHROO-UHFFFAOYSA-N 50179522 CHEMBL3814289 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179522&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127052125 346549594 CHEMBL3814289 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501210 CCCC(=O)Oc1ccc2c(c1)oc(=O)n(Cc1cccc(NS(=O)(=O)NC)c1F)c2=O InChI=1S/C20H20FN3O7S/c1-3-5-17(25)30-13-8-9-14-16(10-13)31-20(27)24(19(14)26)11-12-6-4-7-15(18(12)21)23-32(28,29)22-2/h4,6-10,22-23H,3,5,11H2,1-2H3 BCFLRYFKNBAZHJ-UHFFFAOYSA-N 50179523 CHEMBL3815032 Serine/threonine-protein kinase B-raf Homo sapiens 1200 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179523&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127052123 346549595 CHEMBL3815032 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501214 CNS(=O)(=O)Nc1cccc(Cn2c(=O)oc3cc(OC(C)=O)ccc3c2=O)c1F InChI=1S/C18H16FN3O7S/c1-10(23)28-12-6-7-13-15(8-12)29-18(25)22(17(13)24)9-11-4-3-5-14(16(11)19)21-30(26,27)20-2/h3-8,20-21H,9H2,1-2H3 GUCAUSGSYGTPSO-UHFFFAOYSA-N 50179524 CHEMBL3814543 Serine/threonine-protein kinase B-raf Homo sapiens 610 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179524&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048328 346549596 CHEMBL3814543 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501215 CCC(=O)Oc1ccc2c(c1)oc(=O)n(Cc1cccc(NS(=O)(=O)NC)c1F)c2=O InChI=1S/C19H18FN3O7S/c1-3-16(24)29-12-7-8-13-15(9-12)30-19(26)23(18(13)25)10-11-5-4-6-14(17(11)20)22-31(27,28)21-2/h4-9,21-22H,3,10H2,1-2H3 MZIZUNUKDZJTOZ-UHFFFAOYSA-N 50179525 CHEMBL3813945 Serine/threonine-protein kinase B-raf Homo sapiens 230 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179525&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048329 346549597 CHEMBL3813945 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501216 CNS(=O)(=O)Nc1cccc(Cn2c(=O)oc3cc(OC(=O)C(C)C)ccc3c2=O)c1F InChI=1S/C20H20FN3O7S/c1-11(2)19(26)30-13-7-8-14-16(9-13)31-20(27)24(18(14)25)10-12-5-4-6-15(17(12)21)23-32(28,29)22-3/h4-9,11,22-23H,10H2,1-3H3 ZVAVSIROVSNHJZ-UHFFFAOYSA-N 50179526 CHEMBL3814233 Serine/threonine-protein kinase B-raf Homo sapiens 720 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179526&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048676 346549598 CHEMBL3814233 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501217 CNS(=O)(=O)Nc1cccc(Cn2c(=O)oc3cc(OS(C)(=O)=O)ccc3c2=O)c1F InChI=1S/C17H16FN3O8S2/c1-19-31(26,27)20-13-5-3-4-10(15(13)18)9-21-16(22)12-7-6-11(29-30(2,24)25)8-14(12)28-17(21)23/h3-8,19-20H,9H2,1-2H3 RBQHLZJOEPCDFV-UHFFFAOYSA-N 50179527 CHEMBL3814868 Serine/threonine-protein kinase B-raf Homo sapiens 2540 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179527&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048677 346549599 CHEMBL3814868 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501218 CCS(=O)(=O)Oc1ccc2c(c1)oc(=O)n(Cc1cccc(NS(=O)(=O)NC)c1F)c2=O InChI=1S/C18H18FN3O8S2/c1-3-31(25,26)30-12-7-8-13-15(9-12)29-18(24)22(17(13)23)10-11-5-4-6-14(16(11)19)21-32(27,28)20-2/h4-9,20-21H,3,10H2,1-2H3 GHPAVDUROZUHKQ-UHFFFAOYSA-N 50179528 CHEMBL3814118 Serine/threonine-protein kinase B-raf Homo sapiens 670 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179528&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048678 346549600 CHEMBL3814118 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501219 CN(C)C(=O)Oc1ccc2c(c1)oc(=O)n(Cc1cccc(NS(=O)(=O)NCc3ccccc3)c1F)c2=O InChI=1S/C25H23FN4O7S/c1-29(2)24(32)36-18-11-12-19-21(13-18)37-25(33)30(23(19)31)15-17-9-6-10-20(22(17)26)28-38(34,35)27-14-16-7-4-3-5-8-16/h3-13,27-28H,14-15H2,1-2H3 KIWHVDKXYWSISW-UHFFFAOYSA-N 50179529 CHEMBL3814639 Serine/threonine-protein kinase B-raf Homo sapiens 1490 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179529&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127048327 346549601 CHEMBL3814639 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501220 CN(C)C(=O)Oc1ccc2c(c1)oc(=O)n(Cc1cccc(NS(=O)(=O)Nc3ccccc3)c1F)c2=O InChI=1S/C24H21FN4O7S/c1-28(2)23(31)35-17-11-12-18-20(13-17)36-24(32)29(22(18)30)14-15-7-6-10-19(21(15)25)27-37(33,34)26-16-8-4-3-5-9-16/h3-13,26-27H,14H2,1-2H3 UWTJHCNABDWRAA-UHFFFAOYSA-N 50179530 CHEMBL3814758 Serine/threonine-protein kinase B-raf Homo sapiens 1640 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179530&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127049665 346549602 CHEMBL3814758 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501221 CC(C)NS(=O)(=O)Nc1cccc(Cn2c(=O)oc3cc(OC(=O)N(C)C)ccc3c2=O)c1F InChI=1S/C21H23FN4O7S/c1-12(2)23-34(30,31)24-16-7-5-6-13(18(16)22)11-26-19(27)15-9-8-14(32-20(28)25(3)4)10-17(15)33-21(26)29/h5-10,12,23-24H,11H2,1-4H3 BFEHBFRVNJDJJL-UHFFFAOYSA-N 50179531 CHEMBL3815096 Serine/threonine-protein kinase B-raf Homo sapiens 210 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179531&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127049664 346549603 CHEMBL3815096 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501222 CN(C)C(=O)Oc1ccc2c(c1)oc(=O)n(Cc1cccc(NS(=O)(=O)NCCC#N)c1F)c2=O InChI=1S/C21H20FN5O7S/c1-26(2)20(29)33-14-7-8-15-17(11-14)34-21(30)27(19(15)28)12-13-5-3-6-16(18(13)22)25-35(31,32)24-10-4-9-23/h3,5-8,11,24-25H,4,10,12H2,1-2H3 WPDBDHCUCQOOTQ-UHFFFAOYSA-N 50179615 CHEMBL3814173 Serine/threonine-protein kinase B-raf Homo sapiens 60 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179615&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127049663 104064764 CHEMBL3814173 ZINC28570551 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501223 CN(C)C(=O)Oc1ccc2c(c1)oc(=O)n(Cc1cccc(NS(=O)(=O)NCC(F)(F)F)c1F)c2=O InChI=1S/C20H18F4N4O7S/c1-27(2)18(30)34-12-6-7-13-15(8-12)35-19(31)28(17(13)29)9-11-4-3-5-14(16(11)21)26-36(32,33)25-10-20(22,23)24/h3-8,25-26H,9-10H2,1-2H3 ZIHQAIDCEQXGDJ-UHFFFAOYSA-N 50179650 CHEMBL3814582 Serine/threonine-protein kinase B-raf Homo sapiens 420 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179650&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127049662 346549604 CHEMBL3814582 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501224 CNS(=O)(=O)Nc1cccc(Cn2c(=O)oc3cc(OC(=O)N(C)C)ccc3c2=O)c1F InChI=1S/C19H19FN4O7S/c1-21-32(28,29)22-14-6-4-5-11(16(14)20)10-24-17(25)13-8-7-12(30-18(26)23(2)3)9-15(13)31-19(24)27/h4-9,21-22H,10H2,1-3H3 QXVGNWIPGKANMZ-UHFFFAOYSA-N 50179651 CHEMBL3814978 Serine/threonine-protein kinase B-raf Homo sapiens 55 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179651&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127049661 346549605 CHEMBL3814978 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501225 CN(C)C(=O)Oc1ccc2c(c1)oc(=O)n(Cc1cccc(NS(N)(=O)=O)c1F)c2=O InChI=1S/C18H17FN4O7S/c1-22(2)17(25)29-11-6-7-12-14(8-11)30-18(26)23(16(12)24)9-10-4-3-5-13(15(10)19)21-31(20,27)28/h3-8,21H,9H2,1-2H3,(H2,20,27,28) JFGVFSHQBGUZOT-UHFFFAOYSA-N 50179759 CHEMBL3814609 Serine/threonine-protein kinase B-raf Homo sapiens 840 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179759&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127049660 104064906 CHEMBL3814609 ZINC28572158 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501226 CCS(=O)(=O)Nc1cccc(Cn2c(=O)oc3cc(OC(=O)N(C)C)ccc3c2=O)c1F InChI=1S/C20H20FN3O7S/c1-4-32(28,29)22-15-7-5-6-12(17(15)21)11-24-18(25)14-9-8-13(30-19(26)23(2)3)10-16(14)31-20(24)27/h5-10,22H,4,11H2,1-3H3 JMZFSFFYQKQNNH-UHFFFAOYSA-N 50179765 CHEMBL3814830 Serine/threonine-protein kinase B-raf Homo sapiens 200 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179765&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127049965 104064912 CHEMBL3814830 ZINC28572247 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501227 CN(C)C(=O)Oc1ccc2oc(=O)n(Cc3cccc(NS(C)(=O)=O)c3F)c(=O)c2c1 InChI=1S/C19H18FN3O7S/c1-22(2)18(25)29-12-7-8-15-13(9-12)17(24)23(19(26)30-15)10-11-5-4-6-14(16(11)20)21-31(3,27)28/h4-9,21H,10H2,1-3H3 CBDDAWMEVYEOTC-UHFFFAOYSA-N 50179831 CHEMBL3814347 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179831&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127049964 104064978 CHEMBL3814347 ZINC28571381 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501228 CN(C)C(=O)Oc1ccc2c(c1)oc(=O)n(Cc1cccc(NC(C)=O)c1)c2=O InChI=1S/C20H19N3O6/c1-12(24)21-14-6-4-5-13(9-14)11-23-18(25)16-8-7-15(28-19(26)22(2)3)10-17(16)29-20(23)27/h4-10H,11H2,1-3H3,(H,21,24) FGDMAJAPDHFDJE-UHFFFAOYSA-N 50179832 CHEMBL3814281 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179832&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127049963 104064979 CHEMBL3814281 ZINC28572157 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501229 CN(C)C(=O)Oc1ccc2c(c1)oc(=O)n(Cc1ccc(F)c(NS(C)(=O)=O)c1)c2=O InChI=1S/C19H18FN3O7S/c1-22(2)18(25)29-12-5-6-13-16(9-12)30-19(26)23(17(13)24)10-11-4-7-14(20)15(8-11)21-31(3,27)28/h4-9,21H,10H2,1-3H3 WJVHAQGOSZKKBX-UHFFFAOYSA-N 50179900 CHEMBL3815083 Serine/threonine-protein kinase B-raf Homo sapiens 9870 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179900&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127049962 104065047 CHEMBL3815083 ZINC28572354 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501230 CN(C)C(=O)Oc1ccc2c(c1)oc(=O)n(Cc1cccc(NS(C)(=O)=O)c1F)c2=O InChI=1S/C19H18FN3O7S/c1-22(2)18(25)29-12-7-8-13-15(9-12)30-19(26)23(17(13)24)10-11-5-4-6-14(16(11)20)21-31(3,27)28/h4-9,21H,10H2,1-3H3 PHMNEIZWDRZREQ-UHFFFAOYSA-N 50179901 CHEMBL3814531 Serine/threonine-protein kinase B-raf Homo sapiens 300 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179901&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127049961 104065048 CHEMBL3814531 ZINC28572258 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501231 CN(C)C(=O)Oc1ccc2c(c1)oc(=O)n(Cc1ccc(NS(C)(=O)=O)cc1)c2=O InChI=1S/C19H19N3O7S/c1-21(2)18(24)28-14-8-9-15-16(10-14)29-19(25)22(17(15)23)11-12-4-6-13(7-5-12)20-30(3,26)27/h4-10,20H,11H2,1-3H3 IGBPRGYLOFKEOD-UHFFFAOYSA-N 50179902 CHEMBL3814188 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179902&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127049960 104065049 CHEMBL3814188 ZINC28572623 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501232 CN(C)C(=O)Oc1ccc2c(c1)oc(=O)n(Cc1ccccc1NS(C)(=O)=O)c2=O InChI=1S/C19H19N3O7S/c1-21(2)18(24)28-13-8-9-14-16(10-13)29-19(25)22(17(14)23)11-12-6-4-5-7-15(12)20-30(3,26)27/h4-10,20H,11H2,1-3H3 VNYZVDIHERHAFL-UHFFFAOYSA-N 50179910 CHEMBL3814720 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179910&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127049658 104065057 CHEMBL3814720 ZINC28572256 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501233 CN(C)C(=O)Oc1ccc2c(c1)oc(=O)n(Cc1cccc(NS(C)(=O)=O)c1)c2=O InChI=1S/C19H19N3O7S/c1-21(2)18(24)28-14-7-8-15-16(10-14)29-19(25)22(17(15)23)11-12-5-4-6-13(9-12)20-30(3,26)27/h4-10,20H,11H2,1-3H3 DECLKRAUWLZAGT-UHFFFAOYSA-N 50179913 CHEMBL3814049 Serine/threonine-protein kinase B-raf Homo sapiens 5920 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179913&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127051468 104065060 CHEMBL3814049 ZINC36080435 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501234 CN(C)C(=O)Oc1ccc2c(c1)oc(=O)n(Cc1cccc(c1)[N+]([O-])=O)c2=O InChI=1S/C18H15N3O7/c1-19(2)17(23)27-13-6-7-14-15(9-13)28-18(24)20(16(14)22)10-11-4-3-5-12(8-11)21(25)26/h3-9H,10H2,1-2H3 CCLCEAHCIRSECN-UHFFFAOYSA-N 50179914 CHEMBL3814534 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179914&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127051168 104065061 CHEMBL3814534 ZINC28572531 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501235 CN(C)C(=O)Oc1ccc2c(c1)oc(=O)n(Cc1ccc(F)cc1)c2=O InChI=1S/C18H15FN2O5/c1-20(2)17(23)25-13-7-8-14-15(9-13)26-18(24)21(16(14)22)10-11-3-5-12(19)6-4-11/h3-9H,10H2,1-2H3 NHLHEQCNALIJGK-UHFFFAOYSA-N 50179988 CHEMBL3814261 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179988&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127051167 346549606 CHEMBL3814261 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501236 CN(C)C(=O)Oc1ccc2c(c1)oc(=O)n(Cc1ccccc1F)c2=O InChI=1S/C18H15FN2O5/c1-20(2)17(23)25-12-7-8-13-15(9-12)26-18(24)21(16(13)22)10-11-5-3-4-6-14(11)19/h3-9H,10H2,1-2H3 DXZTXYBYRHWVBM-UHFFFAOYSA-N 50179989 CHEMBL3814337 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179989&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 127051166 346549607 CHEMBL3814337 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501237 CN(C)C(=O)Oc1ccc2c(C)c(Cc3ccc(F)cc3)c(=O)oc2c1 InChI=1S/C20H18FNO4/c1-12-16-9-8-15(25-20(24)22(2)3)11-18(16)26-19(23)17(12)10-13-4-6-14(21)7-5-13/h4-9,11H,10H2,1-3H3 ZJZMAUBKRKIVPH-UHFFFAOYSA-N 50179990 CHEMBL78779 Serine/threonine-protein kinase B-raf Homo sapiens 320 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179990&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2730801 346549608 CHEMBL78779 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501238 Nc1ccccc1SC(=N)C(C#N)C(C#N)C(=N)Sc1ccccc1N InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8,11-12,23-24H,21-22H2 ZCHZSBUNJOCWCW-UHFFFAOYSA-N 50072147 (2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile::1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene::1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene monoethanolate::2,3-Bis-[1-amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-ylidene]-succinonitrile::2,3-Bis-[amino-(2-amino-phenylsulfanyl)-methylene]-succinonitrile::2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile::2-[1-Amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-ylidene]-3-[1-amino-1-(2-amino-phenylsulfanyl)-meth-(E)-ylidene]-succinonitrile::2-[Amino-(2-amino-phenylsulfanyl)-methylene]-3-[1-amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-ylidene]-succinonitrile::CHEMBL100473::CHEMBL95758::U-0126 Serine/threonine-protein kinase B-raf Homo sapiens 250 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072147&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54539763 103965803 64208 CHEMBL95758CHEMBL100473 5282 ZINC02575702 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50501239 OC[C@@H](O)CONC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1 SUDAHWBOROXANE-SECBINFHSA-N 104963 CHEMBL507361::US11147816, PD0325901::US11701360, PD0325901::US8575391, Q Serine/threonine-protein kinase B-raf Homo sapiens 6.0 ChEMBL 10.1016/j.bmc.2016.05.055 10.7270/Q251415P 27288186 Sun, J; Niu, Y; Wang, C; Zhang, H; Xie, B; Xu, F; Jin, H; Peng, Y; Liang, L; Xu, P Peking University Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=104963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=104963&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 4BM 3EQG,7M0X,3VVH,7JV0,7JUU 9826528 172542723 CHEMBL507361 DB07101 ZINC03938683 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509059 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2ccnn12 InChI=1S/C20H13F3N4O/c21-20(22,23)15-5-1-4-14(11-15)19(28)26-16-6-2-3-13(12-16)17-7-9-24-18-8-10-25-27(17)18/h1-12H,(H,26,28) BMVFRDWYIBSEOB-UHFFFAOYSA-N 50294429 CHEMBL560903::N-(3-(pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294429&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45267989 104135960 CHEMBL560903 ZINC43122830 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509060 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)Nc2cc(ccc2Cl)C(F)(F)F)c1 InChI=1S/C23H17ClF3N5O3/c1-2-35-21(33)16-12-29-32-19(8-9-28-20(16)32)13-4-3-5-15(10-13)30-22(34)31-18-11-14(23(25,26)27)6-7-17(18)24/h3-12H,2H2,1H3,(H2,30,31,34) UPGIBCIKARSXHH-UHFFFAOYSA-N 50294430 CHEMBL560707::ethyl 7-(3-(3-(2-chloro-5-(trifluoromethyl)phenyl)ureido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294430&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969752 104135961 CHEMBL560707 ZINC43014770 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509061 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)Nc2ccc(F)c(c2)C(F)(F)F)c1 InChI=1S/C23H17F4N5O3/c1-2-35-21(33)16-12-29-32-19(8-9-28-20(16)32)13-4-3-5-14(10-13)30-22(34)31-15-6-7-18(24)17(11-15)23(25,26)27/h3-12H,2H2,1H3,(H2,30,31,34) ZGBMECOLLYUEEF-UHFFFAOYSA-N 50294431 CHEMBL561243::ethyl 7-(3-(3-(4-fluoro-3-(trifluoromethyl)phenyl)ureido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 240 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294431&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969839 104135962 CHEMBL561243 ZINC43077635 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509062 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1 InChI=1S/C23H17ClF3N5O3/c1-2-35-21(33)16-12-29-32-19(8-9-28-20(16)32)13-4-3-5-14(10-13)30-22(34)31-15-6-7-18(24)17(11-15)23(25,26)27/h3-12H,2H2,1H3,(H2,30,31,34) CJQIUJARLBWAAK-UHFFFAOYSA-N 50294432 CHEMBL564895::ethyl 7-(3-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 360 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294432&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969397 104135963 CHEMBL564895 ZINC43024607 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509063 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)Nc2ccc(C)c(c2)C(F)(F)F)c1 InChI=1S/C24H20F3N5O3/c1-3-35-22(33)18-13-29-32-20(9-10-28-21(18)32)15-5-4-6-16(11-15)30-23(34)31-17-8-7-14(2)19(12-17)24(25,26)27/h4-13H,3H2,1-2H3,(H2,30,31,34) FPSRNOKVAICOEK-UHFFFAOYSA-N 50294433 CHEMBL551905::ethyl 7-(3-(3-(4-methyl-3-(trifluoromethyl)phenyl)ureido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 360 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294433&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969040 104135964 CHEMBL551905 ZINC43120026 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509064 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)Nc2cccc(Cl)c2)c1 InChI=1S/C22H18ClN5O3/c1-2-31-21(29)18-13-25-28-19(9-10-24-20(18)28)14-5-3-7-16(11-14)26-22(30)27-17-8-4-6-15(23)12-17/h3-13H,2H2,1H3,(H2,26,27,30) HHIARXWMNWOFMV-UHFFFAOYSA-N 50294434 CHEMBL561043::ethyl 7-(3-(3-(3-chlorophenyl)ureido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294434&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969041 104135965 CHEMBL561043 ZINC43079762 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509065 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)Nc2ccccc2C(F)(F)F)c1 InChI=1S/C23H18F3N5O3/c1-2-34-21(32)16-13-28-31-19(10-11-27-20(16)31)14-6-5-7-15(12-14)29-22(33)30-18-9-4-3-8-17(18)23(24,25)26/h3-13H,2H2,1H3,(H2,29,30,33) LAWNIAKHSWIXMG-UHFFFAOYSA-N 50294435 CHEMBL551176::ethyl 7-(3-(3-(2-(trifluoromethyl)phenyl)ureido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294435&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969834 104135966 CHEMBL551176 ZINC43062830 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509066 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)Nc2ccc(cc2)C(F)(F)F)c1 InChI=1S/C23H18F3N5O3/c1-2-34-21(32)18-13-28-31-19(10-11-27-20(18)31)14-4-3-5-17(12-14)30-22(33)29-16-8-6-15(7-9-16)23(24,25)26/h3-13H,2H2,1H3,(H2,29,30,33) FIYJRDXUBRXNNM-UHFFFAOYSA-N 50294436 CHEMBL562424::ethyl 7-(3-(3-(4-(trifluoromethyl)phenyl)ureido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 3600 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294436&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969750 104135967 CHEMBL562424 ZINC43120107 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509067 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)Nc2cccc(c2)C(F)(F)F)c1 InChI=1S/C23H18F3N5O3/c1-2-34-21(32)18-13-28-31-19(9-10-27-20(18)31)14-5-3-7-16(11-14)29-22(33)30-17-8-4-6-15(12-17)23(24,25)26/h3-13H,2H2,1H3,(H2,29,30,33) CZTSQNOAVFMDAC-UHFFFAOYSA-N 50294437 CHEMBL560642::ethyl 7-(3-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 540 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294437&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969749 104135968 CHEMBL560642 ZINC43068845 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509068 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cc(ccc2Cl)C(F)(F)F)c1 InChI=1S/C23H16ClF3N4O3/c1-2-34-22(33)17-12-29-31-19(8-9-28-20(17)31)13-4-3-5-15(10-13)30-21(32)16-11-14(23(25,26)27)6-7-18(16)24/h3-12H,2H2,1H3,(H,30,32) MLVZYGLMGPHIKH-UHFFFAOYSA-N 50294438 CHEMBL551173::ethyl 7-(3-(2-chloro-5-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294438&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969487 104135969 CHEMBL551173 ZINC43061997 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509069 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cc(ccc2C)C(F)(F)F)c1 InChI=1S/C24H19F3N4O3/c1-3-34-23(33)19-13-29-31-20(9-10-28-21(19)31)15-5-4-6-17(11-15)30-22(32)18-12-16(24(25,26)27)8-7-14(18)2/h4-13H,3H2,1-2H3,(H,30,32) CIIPGJWPWFJSJQ-UHFFFAOYSA-N 50294439 CHEMBL563229::ethyl 7-(3-(2-methyl-5-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294439&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45271358 104135970 CHEMBL563229 ZINC43018187 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509070 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2ccc(Cl)c(c2)C(F)(F)F)c1 InChI=1S/C23H16ClF3N4O3/c1-2-34-22(33)16-12-29-31-19(8-9-28-20(16)31)13-4-3-5-15(10-13)30-21(32)14-6-7-18(24)17(11-14)23(25,26)27/h3-12H,2H2,1H3,(H,30,32) KUNDZSRQVZNOAB-UHFFFAOYSA-N 50294440 CHEMBL564192::ethyl 7-(3-(4-chloro-3-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 4270 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294440&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969401 104135971 CHEMBL564192 ZINC43119980 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509071 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2ccc(OC)c(c2)C(F)(F)F)c1 InChI=1S/C24H19F3N4O4/c1-3-35-23(33)17-13-29-31-19(9-10-28-21(17)31)14-5-4-6-16(11-14)30-22(32)15-7-8-20(34-2)18(12-15)24(25,26)27/h4-13H,3H2,1-2H3,(H,30,32) OQAJZRGPPOXKEL-UHFFFAOYSA-N 50294441 CHEMBL549824::ethyl 7-(3-(4-methoxy-3-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 1030 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294441&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969567 104135972 CHEMBL549824 ZINC43013637 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509072 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2ccc(C)c(c2)C(F)(F)F)c1 InChI=1S/C24H19F3N4O3/c1-3-34-23(33)18-13-29-31-20(9-10-28-21(18)31)15-5-4-6-17(11-15)30-22(32)16-8-7-14(2)19(12-16)24(25,26)27/h4-13H,3H2,1-2H3,(H,30,32) LNEZCTJJIDDWKC-UHFFFAOYSA-N 50294442 CHEMBL549823::ethyl 7-(3-(4-methyl-3-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 500 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294442&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969668 104135973 CHEMBL549823 ZINC43015947 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509073 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2ccc(cc2)C(F)(F)F)c1 InChI=1S/C23H17F3N4O3/c1-2-33-22(32)18-13-28-30-19(10-11-27-20(18)30)15-4-3-5-17(12-15)29-21(31)14-6-8-16(9-7-14)23(24,25)26/h3-13H,2H2,1H3,(H,29,31) JIVQWFZRSLHDMU-UHFFFAOYSA-N 50294443 CHEMBL549822::ethyl 7-(3-(4-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294443&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969396 104135974 CHEMBL549822 ZINC43015160 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509074 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(OC(F)(F)F)c2)c1 InChI=1S/C23H17F3N4O4/c1-2-33-22(32)18-13-28-30-19(9-10-27-20(18)30)14-5-3-7-16(11-14)29-21(31)15-6-4-8-17(12-15)34-23(24,25)26/h3-13H,2H2,1H3,(H,29,31) UJQMWDXTLBSHIG-UHFFFAOYSA-N 50294444 CHEMBL549619::ethyl 7-(3-(3-(trifluoromethoxy)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 1570 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294444&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969393 104135975 CHEMBL549619 ZINC43018963 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509075 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C#N)c1 InChI=1S/C23H17N5O3/c1-2-31-23(30)19-14-26-28-20(9-10-25-21(19)28)16-6-4-8-18(12-16)27-22(29)17-7-3-5-15(11-17)13-24/h3-12,14H,2H2,1H3,(H,27,29) SLLCNVWKVGYCLX-UHFFFAOYSA-N 50294445 CHEMBL551300::ethyl 7-(3-(3-cyanobenzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294445&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969484 104135976 CHEMBL551300 ZINC43021694 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509076 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(Br)c2)c1 InChI=1S/C22H17BrN4O3/c1-2-30-22(29)18-13-25-27-19(9-10-24-20(18)27)14-5-4-8-17(12-14)26-21(28)15-6-3-7-16(23)11-15/h3-13H,2H2,1H3,(H,26,28) GRNRCYLMJBEEDM-UHFFFAOYSA-N 50294446 CHEMBL554279::ethyl 7-(3-(3-bromobenzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294446&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969304 104135977 CHEMBL554279 ZINC43020104 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509077 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(Cl)c2)c1 InChI=1S/C22H17ClN4O3/c1-2-30-22(29)18-13-25-27-19(9-10-24-20(18)27)14-5-4-8-17(12-14)26-21(28)15-6-3-7-16(23)11-15/h3-13H,2H2,1H3,(H,26,28) GJFRNUBRALSFKT-UHFFFAOYSA-N 50294447 CHEMBL559280::ethyl 7-(3-(3-chlorobenzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294447&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24970246 104135978 CHEMBL559280 ZINC43076371 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509078 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(OC)c2)c1 InChI=1S/C23H20N4O4/c1-3-31-23(29)19-14-25-27-20(10-11-24-21(19)27)15-6-4-8-17(12-15)26-22(28)16-7-5-9-18(13-16)30-2/h4-14H,3H2,1-2H3,(H,26,28) LVNMQZPNEQWUKM-UHFFFAOYSA-N 50294448 CHEMBL549411::ethyl 7-(3-(3-methoxybenzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294448&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969394 104135979 CHEMBL549411 ZINC43016572 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509079 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(C)c2)c1 InChI=1S/C23H20N4O3/c1-3-30-23(29)19-14-25-27-20(10-11-24-21(19)27)16-7-5-9-18(13-16)26-22(28)17-8-4-6-15(2)12-17/h4-14H,3H2,1-2H3,(H,26,28) XFQHIUKTIWAPNS-UHFFFAOYSA-N 50294449 CHEMBL562501::ethyl 7-(3-(3-methylbenzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294449&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45267957 104135980 CHEMBL562501 ZINC43122145 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509080 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2ccccc2)c1 InChI=1S/C22H18N4O3/c1-2-29-22(28)18-14-24-26-19(11-12-23-20(18)26)16-9-6-10-17(13-16)25-21(27)15-7-4-3-5-8-15/h3-14H,2H2,1H3,(H,25,27) CJVWYPWUZIQJFP-UHFFFAOYSA-N 50294450 CHEMBL559650::ethyl 7-(3-benzamidophenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294450&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969303 104135981 CHEMBL559650 ZINC43069741 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509081 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C23H17F3N4O3/c1-2-33-22(32)18-13-28-30-19(9-10-27-20(18)30)14-5-4-8-17(12-14)29-21(31)15-6-3-7-16(11-15)23(24,25)26/h3-13H,2H2,1H3,(H,29,31) YCAVTOUTYRMOGQ-UHFFFAOYSA-N 50294451 CHEMBL565061::ethyl 7-(3-(3-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate::pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 1540 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294451&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969301 104135982 CHEMBL565061 ZINC41739025 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509082 COCCCNC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1 InChI=1S/C25H22ClF3N6O3/c1-38-11-3-9-31-23(36)18-14-32-35-21(8-10-30-22(18)35)15-4-2-5-16(12-15)33-24(37)34-17-6-7-20(26)19(13-17)25(27,28)29/h2,4-8,10,12-14H,3,9,11H2,1H3,(H,31,36)(H2,33,34,37) KLLPYYZIOZFGQS-UHFFFAOYSA-N 50294452 7-(3-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)-N-(3-methoxypropyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide::CHEMBL558490 Serine/threonine-protein kinase B-raf Homo sapiens 270 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294452&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45273140 104135983 CHEMBL558490 ZINC43063625 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509083 FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)-c2ccnc3c(cnn23)C(=O)NCCN2CCOCC2)ccc1Cl InChI=1S/C27H25ClF3N7O3/c28-22-5-4-19(15-21(22)27(29,30)31)36-26(40)35-18-3-1-2-17(14-18)23-6-7-32-24-20(16-34-38(23)24)25(39)33-8-9-37-10-12-41-13-11-37/h1-7,14-16H,8-13H2,(H,33,39)(H2,35,36,40) FWFGUQBBFCETAJ-UHFFFAOYSA-N 50294453 7-(3-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide::CHEMBL541201 Serine/threonine-protein kinase B-raf Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294453&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45269730 104135984 CHEMBL541201 ZINC42920958 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509096 CCN(CC)CCNC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1 InChI=1S/C27H27ClF3N7O2/c1-3-37(4-2)13-12-33-25(39)20-16-34-38-23(10-11-32-24(20)38)17-6-5-7-18(14-17)35-26(40)36-19-8-9-22(28)21(15-19)27(29,30)31/h5-11,14-16H,3-4,12-13H2,1-2H3,(H,33,39)(H2,35,36,40) VWBONYFKEMSEAV-UHFFFAOYSA-N 50294454 7-(3-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)-N-(2-(diethylamino)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide::CHEMBL562168 Serine/threonine-protein kinase B-raf Homo sapiens 170 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294454&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45268883 104135985 CHEMBL562168 ZINC43080734 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509097 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2c(cnn12)C(=O)NCCN1CCOCC1 InChI=1S/C27H25F3N6O3/c28-27(29,30)20-5-1-4-19(15-20)25(37)34-21-6-2-3-18(16-21)23-7-8-31-24-22(17-33-36(23)24)26(38)32-9-10-35-11-13-39-14-12-35/h1-8,15-17H,9-14H2,(H,32,38)(H,34,37) YMPDSPYFMVDETC-UHFFFAOYSA-N 50294455 CHEMBL550290::N-(2-morpholinoethyl)-7-(3-(3-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Serine/threonine-protein kinase B-raf Homo sapiens 6340 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294455&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24970000 104135986 CHEMBL550290 ZINC43010724 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50517899 COc1cc(cc(OC)c1OC)-c1nc(c[nH]c1=O)-c1c[nH]c2ccccc12 InChI=1S/C21H19N3O4/c1-26-17-8-12(9-18(27-2)20(17)28-3)19-21(25)23-11-16(24-19)14-10-22-15-7-5-4-6-13(14)15/h4-11,22H,1-3H3,(H,23,25) CGXHFSJDSWAEMT-UHFFFAOYSA-N 50192858 CHEMBL3358966 Serine/threonine-protein kinase B-raf Homo sapiens >100000 ChEMBL 10.1021/jm500373x 10.7270/Q2ZG6V0R 25007344 Horbert, R; Pinchuk, B; Johannes, E; Schlosser, J; Schmidt, D; Cappel, D; Totzke, F; Schächtele, C; Peifer, C Christian-Albrechts-University of Kiel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192858&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 118723185 350085761 CHEMBL3358966 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509098 CN(C)CCNC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C25H23F3N6O2/c1-33(2)12-11-30-24(36)20-15-31-34-21(9-10-29-22(20)34)16-5-4-8-19(14-16)32-23(35)17-6-3-7-18(13-17)25(26,27)28/h3-10,13-15H,11-12H2,1-2H3,(H,30,36)(H,32,35) LBMOATDHLVFWMQ-UHFFFAOYSA-N 50294456 CHEMBL551372::N-(2-(dimethylamino)ethyl)-7-(3-(3-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Serine/threonine-protein kinase B-raf Homo sapiens 5880 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294456&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969923 104135987 CHEMBL551372 ZINC43059782 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509099 CNC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C22H16F3N5O2/c1-26-21(32)17-12-28-30-18(8-9-27-19(17)30)13-4-3-7-16(11-13)29-20(31)14-5-2-6-15(10-14)22(23,24)25/h2-12H,1H3,(H,26,32)(H,29,31) UNDYKHPZSMWVQR-UHFFFAOYSA-N 50294457 CHEMBL551371::N-methyl-7-(3-(3-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294457&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969568 104135988 CHEMBL551371 ZINC43059238 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509100 NC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C21H14F3N5O2/c22-21(23,24)14-5-1-4-13(9-14)20(31)28-15-6-2-3-12(10-15)17-7-8-26-19-16(18(25)30)11-27-29(17)19/h1-11H,(H2,25,30)(H,28,31) SAKKTHNFOONBJP-UHFFFAOYSA-N 50294458 7-(3-(3-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide::CHEMBL564268 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294458&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24970159 104135989 CHEMBL564268 ZINC43059655 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509101 CN(C)CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C25H22F3N5O3/c1-32(2)11-12-36-24(35)20-15-30-33-21(9-10-29-22(20)33)16-5-4-8-19(14-16)31-23(34)17-6-3-7-18(13-17)25(26,27)28/h3-10,13-15H,11-12H2,1-2H3,(H,31,34) PWKVECBFGMGWLG-UHFFFAOYSA-N 50294459 2-(dimethylamino)ethyl 7-(3-(3-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate::CHEMBL561969 Serine/threonine-protein kinase B-raf Homo sapiens 7070 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294459&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45268879 104135990 CHEMBL561969 ZINC43122556 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509102 FC(F)(F)COC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C23H14F6N4O3/c24-22(25,26)12-36-21(35)17-11-31-33-18(7-8-30-19(17)33)13-3-2-6-16(10-13)32-20(34)14-4-1-5-15(9-14)23(27,28)29/h1-11H,12H2,(H,32,34) CYKSRYDSCLHTAL-UHFFFAOYSA-N 50294460 2,2,2-trifluoroethyl 7-(3-(3-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate::CHEMBL565026 Serine/threonine-protein kinase B-raf Homo sapiens 1450 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294460&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45267129 104135991 CHEMBL565026 ZINC43070457 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509103 COC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C22H15F3N4O3/c1-32-21(31)17-12-27-29-18(8-9-26-19(17)29)13-4-3-7-16(11-13)28-20(30)14-5-2-6-15(10-14)22(23,24)25/h2-12H,1H3,(H,28,30) APAVJWIMYUTAQK-UHFFFAOYSA-N 50294461 CHEMBL549476::methyl 7-(3-(3-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 410 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294461&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45271371 104135992 CHEMBL549476 ZINC43010444 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509104 OC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C21H13F3N4O3/c22-21(23,24)14-5-1-4-13(9-14)19(29)27-15-6-2-3-12(10-15)17-7-8-25-18-16(20(30)31)11-26-28(17)18/h1-11H,(H,27,29)(H,30,31) VAGVIWKTWXOXPO-UHFFFAOYSA-N 50294462 CHEMBL561567::Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294462&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969569 104135993 CHEMBL561567 ZINC43071546 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50509105 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2c(cnn12)C#N InChI=1S/C21H12F3N5O/c22-21(23,24)16-5-1-4-14(9-16)20(30)28-17-6-2-3-13(10-17)18-7-8-26-19-15(11-25)12-27-29(18)19/h1-10,12H,(H,28,30) KLQVNFICRLTGGF-UHFFFAOYSA-N 50294463 CHEMBL561445::N-(3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.129 10.7270/Q28C9W8N 19362830 Gopalsamy, A; Ciszewski, G; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294463&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24970161 104135994 CHEMBL561445 ZINC43074475 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541238 CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc(OC)c1 InChI=1S/C28H29N5O3/c1-3-36-28(34)32-21-7-8-22(32)16-20(15-21)24-11-14-30-27-25(19-5-4-6-23(17-19)35-2)26(31-33(24)27)18-9-12-29-13-10-18/h4-6,9-14,17,20-22H,3,7-8,15-16H2,1-2H3 UOKVJIDDBYIOKR-UHFFFAOYSA-N 50303092 CHEMBL571557::ethyl 3-(3-(3-methoxyphenyl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 87 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303092&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44225585 104157453 CHEMBL571557 ZINC45284930 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541239 CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(Cl)c(OC)c1 InChI=1S/C28H28ClN5O3/c1-3-37-28(35)33-20-5-6-21(33)15-19(14-20)23-10-13-31-27-25(18-4-7-22(29)24(16-18)36-2)26(32-34(23)27)17-8-11-30-12-9-17/h4,7-13,16,19-21H,3,5-6,14-15H2,1-2H3 ZRFVXMOLTJFMLY-UHFFFAOYSA-N 50303093 CHEMBL584739::ethyl 3-(3-(4-chloro-3-methoxyphenyl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 54.1 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303093&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44225811 104157454 CHEMBL584739 ZINC45315866 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541240 CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc(O)c1 InChI=1S/C27H27N5O3/c1-2-35-27(34)31-20-6-7-21(31)15-19(14-20)23-10-13-29-26-24(18-4-3-5-22(33)16-18)25(30-32(23)26)17-8-11-28-12-9-17/h3-5,8-13,16,19-21,33H,2,6-7,14-15H2,1H3 JHJJTKGXMYCBMS-UHFFFAOYSA-N 50303094 CHEMBL571129::ethyl 3-(3-(3-hydroxyphenyl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303094&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44225586 104157455 CHEMBL571129 ZINC45255239 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541241 COc1cccc(c1)-c1c(nn2c(ccnc12)C1CC2CCC(C1)N2)-c1ccncc1 InChI=1S/C25H25N5O/c1-31-21-4-2-3-17(15-21)23-24(16-7-10-26-11-8-16)29-30-22(9-12-27-25(23)30)18-13-19-5-6-20(14-18)28-19/h2-4,7-12,15,18-20,28H,5-6,13-14H2,1H3 QBKVXGRJENYUEM-UHFFFAOYSA-N 50303095 7-(8-azabicyclo[3.2.1]octan-3-yl)-3-(3-methoxyphenyl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine::CHEMBL569735 Serine/threonine-protein kinase B-raf Homo sapiens 70.8 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303095&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44226029 104157456 CHEMBL569735 ZINC45261378 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541242 COc1cc(ccc1Cl)-c1c(nn2c(ccnc12)C1CC2CCC(C1)N2)-c1ccncc1 InChI=1S/C25H24ClN5O/c1-32-22-14-16(2-5-20(22)26)23-24(15-6-9-27-10-7-15)30-31-21(8-11-28-25(23)31)17-12-18-3-4-19(13-17)29-18/h2,5-11,14,17-19,29H,3-4,12-13H2,1H3 YHSPQUQAMQWVAY-UHFFFAOYSA-N 50303096 7-(8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chloro-3-methoxyphenyl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine::CHEMBL583678 Serine/threonine-protein kinase B-raf Homo sapiens 8.5 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303096&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44226026 104157457 CHEMBL583678 ZINC45317522 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541243 Oc1cccc(c1)-c1c(nn2c(ccnc12)C1CC2CCC(C1)N2)-c1ccncc1 InChI=1S/C24H23N5O/c30-20-3-1-2-16(14-20)22-23(15-6-9-25-10-7-15)28-29-21(8-11-26-24(22)29)17-12-18-4-5-19(13-17)27-18/h1-3,6-11,14,17-19,27,30H,4-5,12-13H2 XDBBGTIPWPBPQD-UHFFFAOYSA-N 50303097 3-(7-(8-azabicyclo[3.2.1]octan-3-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-3-yl)phenol::CHEMBL583025 Serine/threonine-protein kinase B-raf Homo sapiens 4 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303097&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44225587 104157458 CHEMBL583025 ZINC45316995 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541244 Oc1cc(ccc1Cl)-c1c(nn2c(ccnc12)C1CC2CCC(C1)N2)-c1ccncc1 InChI=1S/C24H22ClN5O/c25-19-4-1-15(13-21(19)31)22-23(14-5-8-26-9-6-14)29-30-20(7-10-27-24(22)30)16-11-17-2-3-18(12-16)28-17/h1,4-10,13,16-18,28,31H,2-3,11-12H2 BXUSXLRHLADQTP-UHFFFAOYSA-N 50303098 5-(7-(8-azabicyclo[3.2.1]octan-3-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-3-yl)-2-chlorophenol::CHEMBL569081 Serine/threonine-protein kinase B-raf Homo sapiens 0.4 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303098&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44225813 104157459 CHEMBL569081 ZINC45256618 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541245 CCN1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(Cl)c(OC)c1 InChI=1S/C27H28ClN5O/c1-3-32-20-5-6-21(32)15-19(14-20)23-10-13-30-27-25(18-4-7-22(28)24(16-18)34-2)26(31-33(23)27)17-8-11-29-12-9-17/h4,7-13,16,19-21H,3,5-6,14-15H2,1-2H3 OCKPPBHBNNMQNO-UHFFFAOYSA-N 50303099 3-(4-chloro-3-methoxyphenyl)-7-(8-ethyl-8-azabicyclo[3.2.1]octan-3-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine::CHEMBL569768 Serine/threonine-protein kinase B-raf Homo sapiens 43.5 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303099&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44226027 104157460 CHEMBL569768 ZINC45258700 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541246 CCN1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(Cl)c(O)c1 InChI=1S/C26H26ClN5O/c1-2-31-19-4-5-20(31)14-18(13-19)22-9-12-29-26-24(17-3-6-21(27)23(33)15-17)25(30-32(22)26)16-7-10-28-11-8-16/h3,6-12,15,18-20,33H,2,4-5,13-14H2,1H3 BADACZAWMOJZKD-UHFFFAOYSA-N 50303100 2-chloro-5-(7-(8-ethyl-8-azabicyclo[3.2.1]octan-3-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-3-yl)phenol::CHEMBL571130 Serine/threonine-protein kinase B-raf Homo sapiens 0.5 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303100&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44226028 104157461 CHEMBL571130 ZINC45255241 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541247 CCN1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(C#N)c(O)c1 InChI=1S/C27H26N6O/c1-2-32-21-5-6-22(32)14-20(13-21)23-9-12-30-27-25(18-3-4-19(16-28)24(34)15-18)26(31-33(23)27)17-7-10-29-11-8-17/h3-4,7-12,15,20-22,34H,2,5-6,13-14H2,1H3 GKXHNUKICSBSSP-UHFFFAOYSA-N 50303101 4-(7-(8-ethyl-8-azabicyclo[3.2.1]octan-3-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-3-yl)-2-hydroxybenzonitrile::CHEMBL570872 Serine/threonine-protein kinase B-raf Homo sapiens 57.9 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303101&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486218 104157462 CHEMBL570872 ZINC45260208 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541248 CCN1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(F)c(O)c1 InChI=1S/C26H26FN5O/c1-2-31-19-4-5-20(31)14-18(13-19)22-9-12-29-26-24(17-3-6-21(27)23(33)15-17)25(30-32(22)26)16-7-10-28-11-8-16/h3,6-12,15,18-20,33H,2,4-5,13-14H2,1H3 HQTQQNJCSWPZLC-UHFFFAOYSA-N 50303102 5-(7-(8-ethyl-8-azabicyclo[3.2.1]octan-3-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-3-yl)-2-fluorophenol::CHEMBL568855 Serine/threonine-protein kinase B-raf Homo sapiens 3 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303102&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44226657 104157463 CHEMBL568855 ZINC45259057 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541249 CC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(Cl)c(O)c1 InChI=1S/C26H24ClN5O2/c1-15(33)31-19-3-4-20(31)13-18(12-19)22-8-11-29-26-24(17-2-5-21(27)23(34)14-17)25(30-32(22)26)16-6-9-28-10-7-16/h2,5-11,14,18-20,34H,3-4,12-13H2,1H3 QYVQTCVWJYOYCE-UHFFFAOYSA-N 50303103 1-(3-(3-(4-chloro-3-hydroxyphenyl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octan-8-yl)ethanone::CHEMBL578391 Serine/threonine-protein kinase B-raf Homo sapiens 0.3 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303103&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44225814 104157464 CHEMBL578391 ZINC45291547 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541250 CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(F)c(F)c1 InChI=1S/C27H25F2N5O2/c1-2-36-27(35)33-19-4-5-20(33)14-18(13-19)23-9-12-31-26-24(17-3-6-21(28)22(29)15-17)25(32-34(23)26)16-7-10-30-11-8-16/h3,6-12,15,18-20H,2,4-5,13-14H2,1H3 WHZGHOVYVOYEFN-UHFFFAOYSA-N 50303104 CHEMBL571558::ethyl 3-(3-(3,4-difluorophenyl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 302 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303104&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486203 104157465 CHEMBL571558 ZINC45285370 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541251 CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(cc1)-c1nnco1 InChI=1S/C29H27N7O3/c1-2-38-29(37)35-22-7-8-23(35)16-21(15-22)24-11-14-31-27-25(26(34-36(24)27)19-9-12-30-13-10-19)18-3-5-20(6-4-18)28-33-32-17-39-28/h3-6,9-14,17,21-23H,2,7-8,15-16H2,1H3 WODFQKKZUUBQPI-UHFFFAOYSA-N 50303105 CHEMBL583340::ethyl 3-(3-(4-(1,3,4-oxadiazol-2-yl)phenyl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 151 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303105&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486208 104157466 CHEMBL583340 ZINC45321667 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541252 CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc2cc[nH]c2c1 InChI=1S/C29H28N6O2/c1-2-37-29(36)34-22-5-6-23(34)16-21(15-22)25-10-14-32-28-26(20-4-3-18-9-13-31-24(18)17-20)27(33-35(25)28)19-7-11-30-12-8-19/h3-4,7-14,17,21-23,31H,2,5-6,15-16H2,1H3 DHCJWESYOBZCJY-UHFFFAOYSA-N 50303106 CHEMBL583894::ethyl 3-(3-(1H-indol-6-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 36 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303106&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486219 104157467 CHEMBL583894 ZINC45316154 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541253 CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ccc12 InChI=1S/C29H28N6O2/c1-2-37-29(36)34-20-6-7-21(34)17-19(16-20)25-11-15-32-28-26(23-4-3-5-24-22(23)10-14-31-24)27(33-35(25)28)18-8-12-30-13-9-18/h3-5,8-15,19-21,31H,2,6-7,16-17H2,1H3 IBDRNHDMECDKFZ-UHFFFAOYSA-N 50303107 CHEMBL570416::ethyl 3-(3-(1H-indol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303107&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486222 104157468 CHEMBL570416 ZINC45256864 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541254 CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc2CC(=O)Nc2c1 InChI=1S/C29H28N6O3/c1-2-38-29(37)34-21-5-6-22(34)14-20(13-21)24-9-12-31-28-26(19-4-3-18-16-25(36)32-23(18)15-19)27(33-35(24)28)17-7-10-30-11-8-17/h3-4,7-12,15,20-22H,2,5-6,13-14,16H2,1H3,(H,32,36) VNLZZLJDQREEAV-UHFFFAOYSA-N 50303108 CHEMBL568856::ethyl 3-(3-(2-oxoindolin-6-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303108&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44227477 104157469 CHEMBL568856 ZINC45259060 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541255 CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]c(=O)[nH]c12 InChI=1S/C28H27N7O3/c1-2-38-28(37)34-18-6-7-19(34)15-17(14-18)22-10-13-30-26-23(20-4-3-5-21-25(20)32-27(36)31-21)24(33-35(22)26)16-8-11-29-12-9-16/h3-5,8-13,17-19H,2,6-7,14-15H2,1H3,(H2,31,32,36) RJRAKPXBDXRAQH-UHFFFAOYSA-N 50303109 CHEMBL569534::ethyl 3-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303109&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44227474 104157470 CHEMBL569534 ZINC45258670 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541256 CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C28H27N7O2/c1-2-37-28(36)34-19-6-7-20(34)15-18(14-19)24-10-13-30-27-25(21-4-3-5-23-22(21)16-31-32-23)26(33-35(24)27)17-8-11-29-12-9-17/h3-5,8-13,16,18-20H,2,6-7,14-15H2,1H3,(H,31,32) NGWVISUMTZXJND-UHFFFAOYSA-N 50303110 CHEMBL585334::ethyl 3-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303110&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44227053 104157471 CHEMBL585334 ZINC45320555 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541257 OC(=O)[C@H]1CCCN1C(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C31H30N8O3/c40-30(41)26-5-2-14-37(26)31(42)38-20-6-7-21(38)16-19(15-20)25-10-13-33-29-27(22-3-1-4-24-23(22)17-34-35-24)28(36-39(25)29)18-8-11-32-12-9-18/h1,3-4,8-13,17,19-21,26H,2,5-7,14-16H2,(H,34,35)(H,40,41)/t19?,20?,21?,26-/m1/s1 UDKIKURHDLVZDP-WCLRUOPHSA-N 50303111 (2R)-1-(3-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carbonyl)pyrrolidine-2-carboxylic acid::CHEMBL571748 Serine/threonine-protein kinase B-raf Homo sapiens 2.1 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303111&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486210 104157472 CHEMBL571748 ZINC49694895 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541258 CS(=O)(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C26H25N7O2S/c1-36(34,35)33-18-5-6-19(33)14-17(13-18)23-9-12-28-26-24(20-3-2-4-22-21(20)15-29-30-22)25(31-32(23)26)16-7-10-27-11-8-16/h2-4,7-12,15,17-19H,5-6,13-14H2,1H3,(H,29,30) DITZXIXKRKPYIO-UHFFFAOYSA-N 50303112 3-(1H-indazol-4-yl)-7-(8-(methylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine::CHEMBL570453 Serine/threonine-protein kinase B-raf Homo sapiens 4.90 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303112&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486211 104157473 CHEMBL570453 ZINC45256278 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541259 CN(C)C(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C28H28N8O/c1-34(2)28(37)35-19-6-7-20(35)15-18(14-19)24-10-13-30-27-25(21-4-3-5-23-22(21)16-31-32-23)26(33-36(24)27)17-8-11-29-12-9-17/h3-5,8-13,16,18-20H,6-7,14-15H2,1-2H3,(H,31,32) AVQBKIKQPSUKCC-UHFFFAOYSA-N 50303113 3-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-N,N-dimethyl-8-azabicyclo[3.2.1]octane-8-carboxamide::CHEMBL584942 Serine/threonine-protein kinase B-raf Homo sapiens 6.4 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303113&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486223 104157474 CHEMBL584942 ZINC45318702 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541260 CCNC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C28H28N8O/c1-2-30-28(37)35-19-6-7-20(35)15-18(14-19)24-10-13-31-27-25(21-4-3-5-23-22(21)16-32-33-23)26(34-36(24)27)17-8-11-29-12-9-17/h3-5,8-13,16,18-20H,2,6-7,14-15H2,1H3,(H,30,37)(H,32,33) TZHHFHHOPQLJJK-UHFFFAOYSA-N 50303114 3-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-N-ethyl-8-azabicyclo[3.2.1]octane-8-carboxamide::CHEMBL570658 Serine/threonine-protein kinase B-raf Homo sapiens 6.7 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303114&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486225 104157475 CHEMBL570658 ZINC45255213 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541261 CC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C27H25N7O/c1-16(35)33-19-5-6-20(33)14-18(13-19)24-9-12-29-27-25(21-3-2-4-23-22(21)15-30-31-23)26(32-34(24)27)17-7-10-28-11-8-17/h2-4,7-12,15,18-20H,5-6,13-14H2,1H3,(H,30,31) LWABABLLRXSSEZ-UHFFFAOYSA-N 50303115 1-(3-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octan-8-yl)ethanone::CHEMBL570458 Serine/threonine-protein kinase B-raf Homo sapiens 9.1 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303115&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486184 104157476 CHEMBL570458 ZINC45256878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541262 OCCN1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C27H27N7O/c35-13-12-33-19-4-5-20(33)15-18(14-19)24-8-11-29-27-25(21-2-1-3-23-22(21)16-30-31-23)26(32-34(24)27)17-6-9-28-10-7-17/h1-3,6-11,16,18-20,35H,4-5,12-15H2,(H,30,31) OTXSLTBIOFQJDD-UHFFFAOYSA-N 50303116 2-(3-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octan-8-yl)ethanol::CHEMBL570443 Serine/threonine-protein kinase B-raf Homo sapiens 22.8 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303116&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486205 104157477 CHEMBL570443 ZINC45254866 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541263 CC(C)(C)OC(=O)[C@H]1CCCN1C(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C35H38N8O3/c1-35(2,3)46-33(44)29-8-5-17-41(29)34(45)42-23-9-10-24(42)19-22(18-23)28-13-16-37-32-30(25-6-4-7-27-26(25)20-38-39-27)31(40-43(28)32)21-11-14-36-15-12-21/h4,6-7,11-16,20,22-24,29H,5,8-10,17-19H2,1-3H3,(H,38,39)/t22?,23?,24?,29-/m1/s1 RYCGMTHUSRZCGH-OZRJUUBCSA-N 50303117 (2R)-tert-butyl 1-(3-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carbonyl)pyrrolidine-2-carboxylate::CHEMBL571747 Serine/threonine-protein kinase B-raf Homo sapiens 39.4 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303117&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486206 104157478 CHEMBL571747 ZINC49694827 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541264 CCN1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C27H27N7/c1-2-33-19-6-7-20(33)15-18(14-19)24-10-13-29-27-25(21-4-3-5-23-22(21)16-30-31-23)26(32-34(24)27)17-8-11-28-12-9-17/h3-5,8-13,16,18-20H,2,6-7,14-15H2,1H3,(H,30,31) UXIJYJCRXZYOGV-UHFFFAOYSA-N 50303118 7-(8-ethyl-8-azabicyclo[3.2.1]octan-3-yl)-3-(1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine::CHEMBL570422 Serine/threonine-protein kinase B-raf Homo sapiens 46.6 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303118&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44227694 104157479 CHEMBL570422 ZINC45258175 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541265 CC(C)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C28H29N7/c1-17(2)34-20-6-7-21(34)15-19(14-20)25-10-13-30-28-26(22-4-3-5-24-23(22)16-31-32-24)27(33-35(25)28)18-8-11-29-12-9-18/h3-5,8-13,16-17,19-21H,6-7,14-15H2,1-2H3,(H,31,32) XSRXVRQXSQUEKK-UHFFFAOYSA-N 50303119 3-(1H-indazol-4-yl)-7-(8-isopropyl-8-azabicyclo[3.2.1]octan-3-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine::CHEMBL570648 Serine/threonine-protein kinase B-raf Homo sapiens 67 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303119&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486224 104157480 CHEMBL570648 ZINC45254304 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541266 CC(=O)CN1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C28H27N7O/c1-17(36)16-34-20-5-6-21(34)14-19(13-20)25-9-12-30-28-26(22-3-2-4-24-23(22)15-31-32-24)27(33-35(25)28)18-7-10-29-11-8-18/h2-4,7-12,15,19-21H,5-6,13-14,16H2,1H3,(H,31,32) MSOLGELMDCJXDT-UHFFFAOYSA-N 50303120 1-(3-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octan-8-yl)propan-2-one::CHEMBL571971 Serine/threonine-protein kinase B-raf Homo sapiens 75.90 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303120&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486226 104157481 CHEMBL571971 ZINC45287241 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541267 CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(Cl)c2[nH]ncc12 InChI=1S/C28H26ClN7O2/c1-2-38-28(37)35-18-3-4-19(35)14-17(13-18)23-9-12-31-27-24(20-5-6-22(29)26-21(20)15-32-33-26)25(34-36(23)27)16-7-10-30-11-8-16/h5-12,15,17-19H,2-4,13-14H2,1H3,(H,32,33) RGULFRDLCMURRU-UHFFFAOYSA-N 50303121 CHEMBL585144::ethyl 3-(3-(7-chloro-1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 0.4 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303121&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44227055 104157482 CHEMBL585144 ZINC49745411 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541268 CCN1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(Cl)c2[nH]ncc12 InChI=1S/C27H26ClN7/c1-2-34-18-3-4-19(34)14-17(13-18)23-9-12-30-27-24(20-5-6-22(28)26-21(20)15-31-32-26)25(33-35(23)27)16-7-10-29-11-8-16/h5-12,15,17-19H,2-4,13-14H2,1H3,(H,31,32) IUBYJXRDWGEBMX-UHFFFAOYSA-N 50303122 3-(7-chloro-1H-indazol-4-yl)-7-(8-ethyl-8-azabicyclo[3.2.1]octan-3-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine::CHEMBL583245 Serine/threonine-protein kinase B-raf Homo sapiens 4.4 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303122&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44227272 104157483 CHEMBL583245 ZINC45316454 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541269 CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(F)c2[nH]ncc12 InChI=1S/C28H26FN7O2/c1-2-38-28(37)35-18-3-4-19(35)14-17(13-18)23-9-12-31-27-24(20-5-6-22(29)26-21(20)15-32-33-26)25(34-36(23)27)16-7-10-30-11-8-16/h5-12,15,17-19H,2-4,13-14H2,1H3,(H,32,33) SHPHMGLVPMJXAL-UHFFFAOYSA-N 50303123 CHEMBL570681::ethyl 3-(3-(7-fluoro-1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 0.4 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303123&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44227274 104157484 CHEMBL570681 ZINC45258803 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541270 Fc1ccc(-c2c(nn3c(ccnc23)C2CC3CCC(C2)N3)-c2ccncc2)c2cn[nH]c12 InChI=1S/C25H22FN7/c26-20-4-3-18(19-13-29-31-24(19)20)22-23(14-5-8-27-9-6-14)32-33-21(7-10-28-25(22)33)15-11-16-1-2-17(12-15)30-16/h3-10,13,15-17,30H,1-2,11-12H2,(H,29,31) QMRARKCWJXXDNO-UHFFFAOYSA-N 50303124 7-(8-azabicyclo[3.2.1]octan-3-yl)-3-(7-fluoro-1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine::CHEMBL584527 Serine/threonine-protein kinase B-raf Homo sapiens 3.8 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303124&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486187 104157485 CHEMBL584527 ZINC45303331 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541271 CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(c2[nH]ncc12)C(F)(F)F InChI=1S/C29H26F3N7O2/c1-2-41-28(40)38-18-3-4-19(38)14-17(13-18)23-9-12-34-27-24(25(37-39(23)27)16-7-10-33-11-8-16)20-5-6-22(29(30,31)32)26-21(20)15-35-36-26/h5-12,15,17-19H,2-4,13-14H2,1H3,(H,35,36) DDKXQHYUVOMKNO-UHFFFAOYSA-N 50303125 CHEMBL571744::ethyl 3-(2-(pyridin-4-yl)-3-(7-(trifluoromethyl)-1H-indazol-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 4.4 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303125&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44227056 104157486 CHEMBL571744 ZINC49694826 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541272 CCN1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(c2[nH]ncc12)C(F)(F)F InChI=1S/C28H26F3N7/c1-2-37-18-3-4-19(37)14-17(13-18)23-9-12-33-27-24(25(36-38(23)27)16-7-10-32-11-8-16)20-5-6-22(28(29,30)31)26-21(20)15-34-35-26/h5-12,15,17-19H,2-4,13-14H2,1H3,(H,34,35) YCYUGKLDRQEWPK-UHFFFAOYSA-N 50303126 7-(8-ethyl-8-azabicyclo[3.2.1]octan-3-yl)-2-(pyridin-4-yl)-3-(7-(trifluoromethyl)-1H-indazol-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine::CHEMBL570642 Serine/threonine-protein kinase B-raf Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303126&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44227273 104157487 CHEMBL570642 ZINC45255205 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541273 CCOC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(C)c2[nH]ncc12 InChI=1S/C29H29N7O2/c1-3-38-29(37)35-20-5-6-21(35)15-19(14-20)24-10-13-31-28-25(22-7-4-17(2)26-23(22)16-32-33-26)27(34-36(24)28)18-8-11-30-12-9-18/h4,7-13,16,19-21H,3,5-6,14-15H2,1-2H3,(H,32,33) ZLMPYEBWRULOFB-UHFFFAOYSA-N 50303127 CHEMBL583133::ethyl 3-(3-(7-methyl-1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 0.7 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303127&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44227271 104157488 CHEMBL583133 ZINC45315140 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541274 CCN1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(C)c2[nH]ncc12 InChI=1S/C28H29N7/c1-3-34-20-5-6-21(34)15-19(14-20)24-10-13-30-28-25(22-7-4-17(2)26-23(22)16-31-32-26)27(33-35(24)28)18-8-11-29-12-9-18/h4,7-13,16,19-21H,3,5-6,14-15H2,1-2H3,(H,31,32) SGZUELFMGSFLMF-UHFFFAOYSA-N 50303128 7-(8-ethyl-8-azabicyclo[3.2.1]octan-3-yl)-3-(7-methyl-1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine::CHEMBL570444 Serine/threonine-protein kinase B-raf Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303128&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44227270 104157489 CHEMBL570444 ZINC45254868 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541275 CCOC(=O)N1C2CCC1CC(C2)c1c(C)cnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C29H29N7O2/c1-3-38-29(37)35-20-7-8-21(35)14-19(13-20)27-17(2)15-31-28-25(22-5-4-6-24-23(22)16-32-33-24)26(34-36(27)28)18-9-11-30-12-10-18/h4-6,9-12,15-16,19-21H,3,7-8,13-14H2,1-2H3,(H,32,33) ZKAAOAGDQCQJHC-UHFFFAOYSA-N 50303129 CHEMBL585335::ethyl 3-(3-(1H-indazol-4-yl)-6-methyl-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 8.4 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303129&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45486212 104157490 CHEMBL585335 ZINC45320560 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541276 COC(=O)C1CC2N(C)C1Cc1cnc3c(c(nn3c21)-c1ccncc1)-c1ccc(Cl)c(O)c1 InChI=1S/C25H22ClN5O3/c1-30-18-9-15-12-28-24-21(14-3-4-17(26)20(32)10-14)22(13-5-7-27-8-6-13)29-31(24)23(15)19(30)11-16(18)25(33)34-2/h3-8,10,12,16,18-19,32H,9,11H2,1-2H3 ORPGEMOJGKEZOC-UHFFFAOYSA-N 50303130 CHEMBL585148::Methyl 6-(4-chloro-3-hydroxyphenyl)-15-methyl-5-(pyridin-4-yl)-3,4,8,15-tetraazatetracyclo[10.2.1.0^{2,10}.0^{3,7}]pentadeca-2(10),4,6,8-tetraene-13-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 1.6 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303130&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44207796 104157491 CHEMBL585148 ZINC43207426 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541277 CN1C2Cc3cnc4c(c(nn4c3C1CC2CO)-c1ccncc1)-c1ccc(Cl)c(O)c1 InChI=1S/C24H22ClN5O2/c1-29-18-8-15-11-27-24-21(14-2-3-17(25)20(32)10-14)22(13-4-6-26-7-5-13)28-30(24)23(15)19(29)9-16(18)12-31/h2-7,10-11,16,18-19,31-32H,8-9,12H2,1H3 XWTXPJAFVMVCOJ-UHFFFAOYSA-N 50303131 2-chloro-5-[13-(hydroxymethyl)-15-methyl-5-(pyridin-4-yl)-3,4,8,15-tetraazatetracyclo[10.2.1.0^{2,10}.0^{3,7}]pentadeca-2(10),4,6,8-tetraen-6-yl]phenol::CHEMBL570873 Serine/threonine-protein kinase B-raf Homo sapiens 0.6 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303131&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44207797 104157492 CHEMBL570873 ZINC43207428 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50541278 CN1C2Cc3cnc4c(c(nn4c3C1CC2S(=O)(=O)c1ccccc1)-c1ccncc1)-c1ccc(Cl)c(O)c1 InChI=1S/C29H24ClN5O3S/c1-34-22-13-19-16-32-29-26(18-7-8-21(30)24(36)14-18)27(17-9-11-31-12-10-17)33-35(29)28(19)23(34)15-25(22)39(37,38)20-5-3-2-4-6-20/h2-12,14,16,22-23,25,36H,13,15H2,1H3 VLLGNGXWVBPRSJ-UHFFFAOYSA-N 50303132 2-chloro-5-[13-(hydroxymethyl)-15-methyl-5-(pyridin-4-yl)-3,4,8,15-tetraazatetracyclo[10.2.1.0^{2,10}.0^{3,7}]pentadeca-2(10),4,6,8-tetraen-6-yl]phenol::CHEMBL571112 Serine/threonine-protein kinase B-raf Homo sapiens 0.8 ChEMBL 10.1016/j.bmcl.2009.10.058 10.7270/Q2833S34 19875283 Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303132&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44207795 104157493 CHEMBL571112 ZINC43207427 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50552319 Fc1c(NC(=O)c2cccc(OC(F)(F)F)c2)cc(Oc2cccc3[nH]c(=O)[nH]c23)c(F)c1F InChI=1S/C21H11F6N3O4/c22-15-12(28-19(31)9-3-1-4-10(7-9)34-21(25,26)27)8-14(16(23)17(15)24)33-13-6-2-5-11-18(13)30-20(32)29-11/h1-8H,(H,28,31)(H2,29,30,32) VVYFYJMXONNWBA-UHFFFAOYSA-N 50307879 CHEMBL602123::N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)-3-(trifluoromethoxy)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 42 ChEMBL 10.1021/jm901509a 10.7270/Q2R211HN 20148563 Nourry, A; Zambon, A; Davies, L; Niculescu-Duvaz, I; Dijkstra, HP; Menard, D; Gaulon, C; Niculescu-Duvaz, D; Suijkerbuijk, BM; Friedlos, F; Manne, HA; Kirk, R; Whittaker, S; Marais, R; Springer, CJ The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50307879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50307879&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46228951 104162240 CHEMBL602123 ZINC45372227 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50552320 CC(C)(C)c1cc(NC(=O)c2cccc(Oc3cccc4[nH]c(=O)[nH]c34)c2)n(n1)-c1ccccc1 InChI=1S/C27H25N5O3/c1-27(2,3)22-16-23(32(31-22)18-10-5-4-6-11-18)29-25(33)17-9-7-12-19(15-17)35-21-14-8-13-20-24(21)30-26(34)28-20/h4-16H,1-3H3,(H,29,33)(H2,28,30,34) GLDPXWNDIUPOHH-UHFFFAOYSA-N 50307880 CHEMBL598626::N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 1090 ChEMBL 10.1021/jm901509a 10.7270/Q2R211HN 20148563 Nourry, A; Zambon, A; Davies, L; Niculescu-Duvaz, I; Dijkstra, HP; Menard, D; Gaulon, C; Niculescu-Duvaz, D; Suijkerbuijk, BM; Friedlos, F; Manne, HA; Kirk, R; Whittaker, S; Marais, R; Springer, CJ The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50307880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50307880&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46228822 104162241 CHEMBL598626 ZINC45364581 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50552321 CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3cccc4[nH]c(=O)[nH]c34)c2)n(n1)-c1ccccc1 InChI=1S/C27H26N6O3/c1-27(2,3)22-16-23(33(32-22)18-10-5-4-6-11-18)30-25(34)28-17-9-7-12-19(15-17)36-21-14-8-13-20-24(21)31-26(35)29-20/h4-16H,1-3H3,(H2,28,30,34)(H2,29,31,35) YLQMVIRZBOJBCV-UHFFFAOYSA-N 50307878 1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-oxo-2,3-dihydro-1Himidazo[4,5-b]pyridin-7-yloxy)phenyl)urea::CHEMBL597592 Serine/threonine-protein kinase B-raf Homo sapiens 3140 ChEMBL 10.1021/jm901509a 10.7270/Q2R211HN 20148563 Nourry, A; Zambon, A; Davies, L; Niculescu-Duvaz, I; Dijkstra, HP; Menard, D; Gaulon, C; Niculescu-Duvaz, D; Suijkerbuijk, BM; Friedlos, F; Manne, HA; Kirk, R; Whittaker, S; Marais, R; Springer, CJ The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50307878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50307878&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46228508 104162239 CHEMBL597592 ZINC45365573 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561637 CN1C2CCC1CN(C2)c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc(O)c1 InChI=1S/C30H28N6O/c1-34-24-9-10-25(34)19-35(18-24)23-7-5-20(6-8-23)27-13-16-32-30-28(22-3-2-4-26(37)17-22)29(33-36(27)30)21-11-14-31-15-12-21/h2-8,11-17,24-25,37H,9-10,18-19H2,1H3 WUYUTPYOOPWWFT-UHFFFAOYSA-N 50311978 3-(3-hydroxyphenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1080476 Serine/threonine-protein kinase B-raf Homo sapiens 0.900000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311978&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44226447 104146339 CHEMBL1080476 ZINC52569991 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561638 COc1cccc(c1)-c1c(nn2c(ccnc12)-c1ccc(cc1)N1CC2CCC(C1)N2C)-c1ccncc1 InChI=1S/C31H30N6O/c1-35-25-10-11-26(35)20-36(19-25)24-8-6-21(7-9-24)28-14-17-33-31-29(23-4-3-5-27(18-23)38-2)30(34-37(28)31)22-12-15-32-16-13-22/h3-9,12-18,25-26H,10-11,19-20H2,1-2H3 FKRUTODYQQBSGD-UHFFFAOYSA-N 50311979 3-(3-methoxyphenyl)-7-(4-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1080832 Serine/threonine-protein kinase B-raf Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311979&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44226241 104146340 CHEMBL1080832 ZINC52569992 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561639 COc1cc(ccc1Cl)-c1c(nn2c(ccnc12)-c1ccc(cc1)N1CC2CCC(C1)N2C)-c1ccncc1 InChI=1S/C31H29ClN6O/c1-36-24-8-9-25(36)19-37(18-24)23-6-3-20(4-7-23)27-13-16-34-31-29(22-5-10-26(32)28(17-22)39-2)30(35-38(27)31)21-11-14-33-15-12-21/h3-7,10-17,24-25H,8-9,18-19H2,1-2H3 PCVYJQQTOFZNQT-UHFFFAOYSA-N 50311980 3-(4-chloro-3-methoxyphenyl)-7-(4-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1088288 Serine/threonine-protein kinase B-raf Homo sapiens 9.7 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311980&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44226448 104146341 CHEMBL1088288 ZINC49777891 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561640 Oc1cccc(c1)-c1c(nn2c(ccnc12)-c1ccc(NCC23CCN(CC2)CC3)cc1)-c1ccncc1 InChI=1S/C31H30N6O/c38-26-3-1-2-24(20-26)28-29(23-8-14-32-15-9-23)35-37-27(10-16-33-30(28)37)22-4-6-25(7-5-22)34-21-31-11-17-36(18-12-31)19-13-31/h1-10,14-16,20,34,38H,11-13,17-19,21H2 WJWNCJMZJIZAHY-UHFFFAOYSA-N 50311981 3-(2-(pyridin-4-yl)-7-(4-(quinuclidin-4-ylmethylamino)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol::CHEMBL1088289 Serine/threonine-protein kinase B-raf Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311981&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880014 104146342 CHEMBL1088289 ZINC49111099 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561641 Oc1cccc(c1)-c1c(nn2c(ccnc12)-c1ccc(N[C@@H]2CN3CCC2CC3)cc1)-c1ccncc1 InChI=1S/C30H28N6O/c37-25-3-1-2-23(18-25)28-29(22-8-13-31-14-9-22)34-36-27(10-15-32-30(28)36)21-4-6-24(7-5-21)33-26-19-35-16-11-20(26)12-17-35/h1-10,13-15,18,20,26,33,37H,11-12,16-17,19H2/t26-/m1/s1 GMJUHMVIMKBELC-AREMUKBSSA-N 50311982 (S)-3-(2-(pyridin-4-yl)-7-(4-(quinuclidin-3-ylamino)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol::CHEMBL1087510 Serine/threonine-protein kinase B-raf Homo sapiens 1.5 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311982&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880015 104146343 CHEMBL1087510 ZINC49112160 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561642 Oc1cccc(c1)-c1c(nn2c(ccnc12)-c1ccc(N[C@H]2CN3CCC2CC3)cc1)-c1ccncc1 InChI=1S/C30H28N6O/c37-25-3-1-2-23(18-25)28-29(22-8-13-31-14-9-22)34-36-27(10-15-32-30(28)36)21-4-6-24(7-5-21)33-26-19-35-16-11-20(26)12-17-35/h1-10,13-15,18,20,26,33,37H,11-12,16-17,19H2/t26-/m0/s1 GMJUHMVIMKBELC-SANMLTNESA-N 50311983 (R)-3-(2-(pyridin-4-yl)-7-(4-(quinuclidin-3-ylamino)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol::CHEMBL1086871 Serine/threonine-protein kinase B-raf Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311983&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880074 104146344 CHEMBL1086871 ZINC49109945 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561643 Oc1cccc(c1)-c1c(nn2c(ccnc12)-c1ccc(cc1)N1C[C@@H]2C[C@H]1CN2)-c1ccncc1 InChI=1S/C28H24N6O/c35-24-3-1-2-20(14-24)26-27(19-8-11-29-12-9-19)32-34-25(10-13-30-28(26)34)18-4-6-22(7-5-18)33-17-21-15-23(33)16-31-21/h1-14,21,23,31,35H,15-17H2/t21-,23-/m0/s1 ISWMSPMQTFQNOK-GMAHTHKFSA-N 50311984 3-(7-(4-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol::CHEMBL1087000 Serine/threonine-protein kinase B-raf Homo sapiens 0.490000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311984&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880075 104146345 CHEMBL1087000 ZINC49054917 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561644 CN1C[C@@H]2C[C@H]1CN2c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc(O)c1 InChI=1S/C29H26N6O/c1-33-17-24-16-23(33)18-34(24)22-7-5-19(6-8-22)26-11-14-31-29-27(21-3-2-4-25(36)15-21)28(32-35(26)29)20-9-12-30-13-10-20/h2-15,23-24,36H,16-18H2,1H3/t23-,24-/m0/s1 MZPDPRITYJNRSG-ZEQRLZLVSA-N 50311985 3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol::CHEMBL1087650 Serine/threonine-protein kinase B-raf Homo sapiens 0.380000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311985&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880136 104146346 CHEMBL1087650 ZINC49112081 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561645 CCN1C[C@@H]2C[C@H]1CN2c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(F)c(O)c1 InChI=1S/C30H27FN6O/c1-2-35-17-24-16-23(35)18-36(24)22-6-3-19(4-7-22)26-11-14-33-30-28(21-5-8-25(31)27(38)15-21)29(34-37(26)30)20-9-12-32-13-10-20/h3-15,23-24,38H,2,16-18H2,1H3/t23-,24-/m0/s1 FBJYRNGBDFBGRM-ZEQRLZLVSA-N 50311986 5-(7-(4-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2-fluorophenol::CHEMBL1080650 Serine/threonine-protein kinase B-raf Homo sapiens 0.510000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311986&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879449 104146347 CHEMBL1080650 ZINC49033754 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561646 CC(=O)N1C[C@@H]2C[C@H]1CN2c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(F)c(O)c1 InChI=1S/C30H25FN6O2/c1-18(38)35-16-24-15-23(35)17-36(24)22-5-2-19(3-6-22)26-10-13-33-30-28(21-4-7-25(31)27(39)14-21)29(34-37(26)30)20-8-11-32-12-9-20/h2-14,23-24,39H,15-17H2,1H3/t23-,24-/m0/s1 JEJHYHQYTOXLOT-ZEQRLZLVSA-N 50311987 1-((1S,4S)-5-(4-(3-(4-fluoro-3-hydroxyphenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)ethanone::CHEMBL1076206 Serine/threonine-protein kinase B-raf Homo sapiens 0.500000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311987&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879450 104146348 CHEMBL1076206 ZINC49872020 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561647 COc1cccc(c1)-c1c(nn2c(ccnc12)-c1ccc(cc1)N1C[C@@H]2C[C@H]1CN2)-c1ccncc1 InChI=1S/C29H26N6O/c1-36-25-4-2-3-21(15-25)27-28(20-9-12-30-13-10-20)33-35-26(11-14-31-29(27)35)19-5-7-23(8-6-19)34-18-22-16-24(34)17-32-22/h2-15,22,24,32H,16-18H2,1H3/t22-,24-/m0/s1 VJWBZZIGIQBWNR-UPVQGACJSA-N 50311988 7-(4-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-3-(3-methoxyphenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1080651 Serine/threonine-protein kinase B-raf Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311988&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879451 104146349 CHEMBL1080651 ZINC49110060 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561648 COc1cccc(c1)-c1c(nn2c(ccnc12)-c1ccc(cc1F)N1C[C@@H]2C[C@H]1CN2)-c1ccncc1 InChI=1S/C29H25FN6O/c1-37-23-4-2-3-19(13-23)27-28(18-7-10-31-11-8-18)34-36-26(9-12-32-29(27)36)24-6-5-21(15-25(24)30)35-17-20-14-22(35)16-33-20/h2-13,15,20,22,33H,14,16-17H2,1H3/t20-,22-/m0/s1 TVWBHTHGDNQIBV-UNMCSNQZSA-N 50311989 7-(4-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-fluorophenyl)-3-(3-methoxyphenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1080652 Serine/threonine-protein kinase B-raf Homo sapiens 0.440000 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311989&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879452 104146350 CHEMBL1080652 ZINC49033863 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561649 COc1cc(ccc1F)-c1c(nn2c(ccnc12)-c1ccc(cc1)N1C[C@@H]2C[C@H]1CN2)-c1ccncc1 InChI=1S/C29H25FN6O/c1-37-26-14-20(4-7-24(26)30)27-28(19-8-11-31-12-9-19)34-36-25(10-13-32-29(27)36)18-2-5-22(6-3-18)35-17-21-15-23(35)16-33-21/h2-14,21,23,33H,15-17H2,1H3/t21-,23-/m0/s1 ZZBKEJNYVUATIW-GMAHTHKFSA-N 50311990 7-(4-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-3-(4-fluoro-3-methoxyphenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1079785 Serine/threonine-protein kinase B-raf Homo sapiens 8.7 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311990&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879517 104146351 CHEMBL1079785 ZINC49021664 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561650 COc1cccc(c1)-c1c(nn2c(ccnc12)-c1ccc(cc1)N1C[C@@H]2C[C@H]1CN2C)-c1ccncc1 InChI=1S/C30H28N6O/c1-34-18-25-17-24(34)19-35(25)23-8-6-20(7-9-23)27-12-15-32-30-28(22-4-3-5-26(16-22)37-2)29(33-36(27)30)21-10-13-31-14-11-21/h3-16,24-25H,17-19H2,1-2H3/t24-,25-/m0/s1 XGUFURVFQMAHHN-DQEYMECFSA-N 50311991 3-(3-methoxyphenyl)-7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1080615 Serine/threonine-protein kinase B-raf Homo sapiens 8.2 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311991&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879518 104146352 CHEMBL1080615 ZINC49089190 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561651 COc1cc(ccc1F)-c1c(nn2c(ccnc12)-c1ccc(cc1)N1C[C@@H]2C[C@H]1CN2C)-c1ccncc1 InChI=1S/C30H27FN6O/c1-35-17-24-16-23(35)18-36(24)22-6-3-19(4-7-22)26-11-14-33-30-28(21-5-8-25(31)27(15-21)38-2)29(34-37(26)30)20-9-12-32-13-10-20/h3-15,23-24H,16-18H2,1-2H3/t23-,24-/m0/s1 SRWHVBZLJOECLF-ZEQRLZLVSA-N 50311992 3-(4-fluoro-3-methoxyphenyl)-7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1080616 Serine/threonine-protein kinase B-raf Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311992&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879519 104146353 CHEMBL1080616 ZINC49032882 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561652 COc1cc(ccc1F)-c1c(nn2c(ccnc12)-c1ccc(cc1C)N1C[C@@H]2C[C@H]1CN2C)-c1ccncc1 InChI=1S/C31H29FN6O/c1-19-14-22(37-18-23-16-24(37)17-36(23)2)5-6-25(19)27-10-13-34-31-29(21-4-7-26(32)28(15-21)39-3)30(35-38(27)31)20-8-11-33-12-9-20/h4-15,23-24H,16-18H2,1-3H3/t23-,24-/m0/s1 WVGILCCRPFXQQT-ZEQRLZLVSA-N 50311993 3-(4-fluoro-3-methoxyphenyl)-7-(2-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1076233 Serine/threonine-protein kinase B-raf Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311993&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879520 104146354 CHEMBL1076233 ZINC49781226 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561675 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C23H17F3N4O3/c1-2-33-22(32)18-13-28-30-19(9-10-27-20(18)30)14-5-4-8-17(12-14)29-21(31)15-6-3-7-16(11-15)23(24,25)26/h3-13H,2H2,1H3,(H,29,31) YCAVTOUTYRMOGQ-UHFFFAOYSA-N 50294451 CHEMBL565061::ethyl 7-(3-(3-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate::pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 1500 ChEMBL 10.1016/j.bmcl.2009.10.030 10.7270/Q29Z9510 19854649 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294451&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969301 104135982 CHEMBL565061 ZINC41739025 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50562871 Cc1c(C#N)c(N)[nH]c2c(C#N)c(=C)c(=Cc3ccc(O)cc3)c12 InChI=1S/C19H14N4O/c1-10-14(7-12-3-5-13(24)6-4-12)17-11(2)16(9-21)19(22)23-18(17)15(10)8-20/h3-7,23-24H,1,22H2,2H3 LCZYDPXLMLXHLE-UHFFFAOYSA-N 50312523 (E)-2-amino-5-(4-hydroxybenzylidene)-4,6-dimethyl-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile::CHEMBL1082551 Serine/threonine-protein kinase B-raf Homo sapiens 20000 ChEMBL 10.1016/j.ejmech.2009.11.028 10.7270/Q2VQ32SW 19969400 Kolb, S; Goddard, ML; Loukaci, A; Mondesert, O; Ducommun, B; Braud, E; Garbay, C University of Paris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312523&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91937030 104146884 CHEMBL1082551 ZINC34629402 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561786 CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C23H17F3N4O3/c1-2-33-22(32)18-13-28-30-19(9-10-27-20(18)30)14-5-4-8-17(12-14)29-21(31)15-6-3-7-16(11-15)23(24,25)26/h3-13H,2H2,1H3,(H,29,31) YCAVTOUTYRMOGQ-UHFFFAOYSA-N 50294451 CHEMBL565061::ethyl 7-(3-(3-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate::pyrazolo[1,5-a]pyrimidine-3-carboxylate Serine/threonine-protein kinase B-raf Homo sapiens 1500 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294451&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24969301 104135982 CHEMBL565061 ZINC41739025 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561787 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2c(cnn12)C#CCCCN1CCOCC1 InChI=1S/C29H26F3N5O2/c30-29(31,32)24-9-4-8-22(18-24)28(38)35-25-10-5-7-21(19-25)26-11-12-33-27-23(20-34-37(26)27)6-2-1-3-13-36-14-16-39-17-15-36/h4-5,7-12,18-20H,1,3,13-17H2,(H,35,38) SOWMPGHFKGHWIR-UHFFFAOYSA-N 50312044 CHEMBL1080656::N-(3-(3-(5-morpholinopent-1-ynyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 552 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312044&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879877 104146405 CHEMBL1080656 ZINC49774879 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561788 CN1CCN(CCCC#Cc2cnn3c(ccnc23)-c2cccc(NC(=O)c3cccc(c3)C(F)(F)F)c2)CC1 InChI=1S/C30H29F3N6O/c1-37-15-17-38(18-16-37)14-4-2-3-7-24-21-35-39-27(12-13-34-28(24)39)22-8-6-11-26(20-22)36-29(40)23-9-5-10-25(19-23)30(31,32)33/h5-6,8-13,19-21H,2,4,14-18H2,1H3,(H,36,40) YIICPBQWCOBAJU-UHFFFAOYSA-N 50312045 CHEMBL1080268::N-(3-(3-(5-(4-methylpiperazin-1-yl)pent-1-ynyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 842 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312045&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879959 104146406 CHEMBL1080268 ZINC49775124 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561789 CN(C)c1ccc(cc1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C28H22F3N5O/c1-35(2)23-11-9-18(10-12-23)24-17-33-36-25(13-14-32-26(24)36)19-5-4-8-22(16-19)34-27(37)20-6-3-7-21(15-20)28(29,30)31/h3-17H,1-2H3,(H,34,37) LBORYVQDGDVAMG-UHFFFAOYSA-N 50312046 CHEMBL1080269::N-(3-(3-(4-(dimethylamino)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 308 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312046&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879960 104146407 CHEMBL1080269 ZINC49109740 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561790 CN(C)S(=O)(=O)c1ccc(cc1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C28H22F3N5O3S/c1-35(2)40(38,39)23-11-9-18(10-12-23)24-17-33-36-25(13-14-32-26(24)36)19-5-4-8-22(16-19)34-27(37)20-6-3-7-21(15-20)28(29,30)31/h3-17H,1-2H3,(H,34,37) RBGUOHBCKRTPMX-UHFFFAOYSA-N 50312047 CHEMBL1080445::N-(3-(3-(4-(N,N-dimethylsulfamoyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312047&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879961 104146408 CHEMBL1080445 ZINC49774628 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561791 NC(=O)c1cccc(c1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C27H18F3N5O2/c28-27(29,30)20-8-2-7-19(13-20)26(37)34-21-9-3-5-17(14-21)23-10-11-32-25-22(15-33-35(23)25)16-4-1-6-18(12-16)24(31)36/h1-15H,(H2,31,36)(H,34,37) CSYGIPIOQSVIRG-UHFFFAOYSA-N 50312048 CHEMBL1086870::N-(3-(3-(3-carbamoylphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 57 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312048&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880016 104146409 CHEMBL1086870 ZINC49049313 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561792 COCCOCC(=O)Nc1ccc(cc1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C31H26F3N5O4/c1-42-14-15-43-19-28(40)37-24-10-8-20(9-11-24)26-18-36-39-27(12-13-35-29(26)39)21-4-3-7-25(17-21)38-30(41)22-5-2-6-23(16-22)31(32,33)34/h2-13,16-18H,14-15,19H2,1H3,(H,37,40)(H,38,41) UFELNXRWJPVQMY-UHFFFAOYSA-N 50312049 CHEMBL1076439::N-(3-(3-(4-(2-(2-methoxyethoxy)acetamido)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 139 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312049&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880017 104146410 CHEMBL1076439 ZINC49780502 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561793 CN(C)CC(=O)Nc1ccc(cc1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C30H25F3N6O2/c1-38(2)18-27(40)36-23-11-9-19(10-12-23)25-17-35-39-26(13-14-34-28(25)39)20-5-4-8-24(16-20)37-29(41)21-6-3-7-22(15-21)30(31,32)33/h3-17H,18H2,1-2H3,(H,36,40)(H,37,41) BIAGWLDERXRFAW-UHFFFAOYSA-N 50312050 CHEMBL1076440::N-(3-(3-(4-(2-(dimethylamino)acetamido)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 34 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312050&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880018 104146411 CHEMBL1076440 ZINC49780503 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561794 CN(C)CC(=O)Nc1cccc(c1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C30H25F3N6O2/c1-38(2)18-27(40)36-23-10-4-6-19(15-23)25-17-35-39-26(12-13-34-28(25)39)20-7-5-11-24(16-20)37-29(41)21-8-3-9-22(14-21)30(31,32)33/h3-17H,18H2,1-2H3,(H,36,40)(H,37,41) FQOBSFOIGPCIHS-UHFFFAOYSA-N 50312051 CHEMBL1076441::N-(3-(3-(3-(2-(dimethylamino)acetamido)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312051&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880019 104146412 CHEMBL1076441 ZINC49775143 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561795 CN(C)CCc1ccccc1-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C30H26F3N5O/c1-37(2)16-14-20-7-3-4-12-25(20)26-19-35-38-27(13-15-34-28(26)38)21-8-6-11-24(18-21)36-29(39)22-9-5-10-23(17-22)30(31,32)33/h3-13,15,17-19H,14,16H2,1-2H3,(H,36,39) WJTUVBBDWNOHLW-UHFFFAOYSA-N 50312052 CHEMBL1088162::N-(3-(3-(2-(2-(dimethylamino)ethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 318 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312052&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880020 104146413 CHEMBL1088162 ZINC49778069 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561796 CN(C)CCc1cccc(c1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C30H26F3N5O/c1-37(2)15-13-20-6-3-7-21(16-20)26-19-35-38-27(12-14-34-28(26)38)22-8-5-11-25(18-22)36-29(39)23-9-4-10-24(17-23)30(31,32)33/h3-12,14,16-19H,13,15H2,1-2H3,(H,36,39) VGHGSNOCPAQYIA-UHFFFAOYSA-N 50312053 CHEMBL1088295::N-(3-(3-(3-(2-(dimethylamino)ethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 41 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312053&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880021 104146414 CHEMBL1088295 ZINC49777810 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561797 CN(C)CCc1ccc(cc1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C30H26F3N5O/c1-37(2)16-14-20-9-11-21(12-10-20)26-19-35-38-27(13-15-34-28(26)38)22-5-4-8-25(18-22)36-29(39)23-6-3-7-24(17-23)30(31,32)33/h3-13,15,17-19H,14,16H2,1-2H3,(H,36,39) ADDMFZVXYOSSRB-UHFFFAOYSA-N 50312054 CHEMBL1087892::N-(3-(3-(4-(2-(dimethylamino)ethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 26 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312054&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880077 104146415 CHEMBL1087892 ZINC49778105 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561798 CN(C)Cc1ccccc1-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C29H24F3N5O/c1-36(2)18-21-7-3-4-12-24(21)25-17-34-37-26(13-14-33-27(25)37)19-8-6-11-23(16-19)35-28(38)20-9-5-10-22(15-20)29(30,31)32/h3-17H,18H2,1-2H3,(H,35,38) ZREJACCVQDDLSA-UHFFFAOYSA-N 50312055 CHEMBL1087893::N-(3-(3-(2-((dimethylamino)methyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 117 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312055&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880078 104146416 CHEMBL1087893 ZINC49053480 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561799 CN(C)Cc1cccc(c1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C29H24F3N5O/c1-36(2)18-19-6-3-7-20(14-19)25-17-34-37-26(12-13-33-27(25)37)21-8-5-11-24(16-21)35-28(38)22-9-4-10-23(15-22)29(30,31)32/h3-17H,18H2,1-2H3,(H,35,38) YNTFITDLPCWGGI-UHFFFAOYSA-N 50312056 CHEMBL1087894::N-(3-(3-(3-((dimethylamino)methyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 44 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312056&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880079 104146417 CHEMBL1087894 ZINC49112193 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561800 CN(C)Cc1ccc(cc1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C29H24F3N5O/c1-36(2)18-19-9-11-20(12-10-19)25-17-34-37-26(13-14-33-27(25)37)21-5-4-8-24(16-21)35-28(38)22-6-3-7-23(15-22)29(30,31)32/h3-17H,18H2,1-2H3,(H,35,38) AIWJVLQNYNCDSL-UHFFFAOYSA-N 50312057 CHEMBL1087397::N-(3-(3-(4-((dimethylamino)methyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide::N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 24 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312057&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 831 3II5 24884503 104146418 CHEMBL1087397 ZINC44669088 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561801 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2c(cnn12)-c1ccc(CN2CCCC2)cc1 InChI=1S/C31H26F3N5O/c32-31(33,34)25-7-3-6-24(17-25)30(40)37-26-8-4-5-23(18-26)28-13-14-35-29-27(19-36-39(28)29)22-11-9-21(10-12-22)20-38-15-1-2-16-38/h3-14,17-19H,1-2,15-16,20H2,(H,37,40) APMUVXPIJNPXQE-UHFFFAOYSA-N 50312058 CHEMBL1087522::N-(3-(3-(4-(pyrrolidin-1-ylmethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312058&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880105 104146419 CHEMBL1087522 ZINC49777615 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561802 CN1CCN(Cc2ccc(cc2)-c2cnn3c(ccnc23)-c2cccc(NC(=O)c3cccc(c3)C(F)(F)F)c2)CC1 InChI=1S/C32H29F3N6O/c1-39-14-16-40(17-15-39)21-22-8-10-23(11-9-22)28-20-37-41-29(12-13-36-30(28)41)24-4-3-7-27(19-24)38-31(42)25-5-2-6-26(18-25)32(33,34)35/h2-13,18-20H,14-17,21H2,1H3,(H,38,42) BUZOTBWJKYSTEL-UHFFFAOYSA-N 50312059 CHEMBL1076482::N-(3-(3-(4-((4-methylpiperazin-1-yl)methyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 38 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312059&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880106 104146420 CHEMBL1076482 ZINC49780440 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561803 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2c(cnn12)-c1cccnc1 InChI=1S/C25H16F3N5O/c26-25(27,28)19-7-1-5-17(12-19)24(34)32-20-8-2-4-16(13-20)22-9-11-30-23-21(15-31-33(22)23)18-6-3-10-29-14-18/h1-15H,(H,32,34) UAQFLCCYSVWUFS-UHFFFAOYSA-N 50312060 CHEMBL1087523::N-(3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 113 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312060&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880107 104146421 CHEMBL1087523 ZINC49050408 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561804 Nc1ccc(cn1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C25H17F3N6O/c26-25(27,28)18-5-1-4-16(11-18)24(35)33-19-6-2-3-15(12-19)21-9-10-30-23-20(14-32-34(21)23)17-7-8-22(29)31-13-17/h1-14H,(H2,29,31)(H,33,35) UXQZKYRXGWLYAD-UHFFFAOYSA-N 50312061 CHEMBL1087780::N-(3-(3-(6-aminopyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 112 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312061&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880139 104146422 CHEMBL1087780 ZINC49048587 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561805 CN(C)CCNc1ccc(cn1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C29H26F3N7O/c1-38(2)14-13-33-26-10-9-21(17-35-26)24-18-36-39-25(11-12-34-27(24)39)19-5-4-8-23(16-19)37-28(40)20-6-3-7-22(15-20)29(30,31)32/h3-12,15-18H,13-14H2,1-2H3,(H,33,35)(H,37,40) SOMNTMFCUYIBSJ-UHFFFAOYSA-N 50312062 CHEMBL1087781::N-(3-(3-(6-(2-(dimethylamino)ethylamino)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 30 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312062&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 45375869 104146423 CHEMBL1087781 ZINC49777629 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561806 CN1CCN(CC1)c1ccc(cn1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C30H26F3N7O/c1-38-12-14-39(15-13-38)27-9-8-22(18-35-27)25-19-36-40-26(10-11-34-28(25)40)20-4-3-7-24(17-20)37-29(41)21-5-2-6-23(16-21)30(31,32)33/h2-11,16-19H,12-15H2,1H3,(H,37,41) DNDVGFIEWOHGAH-UHFFFAOYSA-N 50312063 CHEMBL1076497::N-(3-(3-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 44 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312063&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880140 104146424 CHEMBL1076497 ZINC49926547 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561807 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2c(cnn12)-c1cnc(nc1)N1CCOCC1 InChI=1S/C28H22F3N7O2/c29-28(30,31)21-5-1-4-19(13-21)26(39)36-22-6-2-3-18(14-22)24-7-8-32-25-23(17-35-38(24)25)20-15-33-27(34-16-20)37-9-11-40-12-10-37/h1-8,13-17H,9-12H2,(H,36,39) QKFNOCRNIKWHQY-UHFFFAOYSA-N 50312064 CHEMBL1087906::N-(3-(3-(2-morpholinopyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 941 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312064&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880141 104146425 CHEMBL1087906 ZINC49780378 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561808 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2c(cnn12)-c1cn[nH]c1 InChI=1S/C23H15F3N6O/c24-23(25,26)17-5-1-4-15(9-17)22(33)31-18-6-2-3-14(10-18)20-7-8-27-21-19(13-30-32(20)21)16-11-28-29-12-16/h1-13H,(H,28,29)(H,31,33) MESKGDQSFWBJSN-UHFFFAOYSA-N 50312065 CHEMBL1081470::N-(3-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 84 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312065&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880225 104146426 CHEMBL1081470 ZINC49036293 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561809 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2c(cnn12)-c1cnn(CCN2CCCC2)c1 InChI=1S/C29H26F3N7O/c30-29(31,32)23-7-3-6-21(15-23)28(40)36-24-8-4-5-20(16-24)26-9-10-33-27-25(18-35-39(26)27)22-17-34-38(19-22)14-13-37-11-1-2-12-37/h3-10,15-19H,1-2,11-14H2,(H,36,40) CNAMYLDNIIXYMW-UHFFFAOYSA-N 50312066 CHEMBL1081647::N-(3-(3-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 393 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312066&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880226 104146427 CHEMBL1081647 ZINC49775033 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561810 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2c(cnn12)-c1ccoc1 InChI=1S/C24H15F3N4O2/c25-24(26,27)18-5-1-4-16(11-18)23(32)30-19-6-2-3-15(12-19)21-7-9-28-22-20(13-29-31(21)22)17-8-10-33-14-17/h1-14H,(H,30,32) YFBUXFYIKJBRER-UHFFFAOYSA-N 50312067 CHEMBL1081817::N-(3-(3-(furan-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 326 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312067&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880227 104146428 CHEMBL1081817 ZINC49034529 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561811 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2c(cnn12)-c1coc(CN2CCCC2)c1 InChI=1S/C29H24F3N5O2/c30-29(31,32)22-7-3-6-20(13-22)28(38)35-23-8-4-5-19(14-23)26-9-10-33-27-25(16-34-37(26)27)21-15-24(39-18-21)17-36-11-1-2-12-36/h3-10,13-16,18H,1-2,11-12,17H2,(H,35,38) UXWQKBQYLIAPJN-UHFFFAOYSA-N 50312068 CHEMBL1081818::N-(3-(3-(5-(pyrrolidin-1-ylmethyl)furan-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 362 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312068&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880228 104146429 CHEMBL1081818 ZINC49792917 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561812 CCN1CCN(Cc2cc(co2)-c2cnn3c(ccnc23)-c2cccc(NC(=O)c3cccc(c3)C(F)(F)F)c2)CC1 InChI=1S/C31H29F3N6O2/c1-2-38-11-13-39(14-12-38)19-26-17-23(20-42-26)27-18-36-40-28(9-10-35-29(27)40)21-5-4-8-25(16-21)37-30(41)22-6-3-7-24(15-22)31(32,33)34/h3-10,15-18,20H,2,11-14,19H2,1H3,(H,37,41) DATHYHLOJYBUAS-UHFFFAOYSA-N 50312069 CHEMBL1076541::N-(3-(3-(5-((4-ethylpiperazin-1-yl)methyl)furan-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 219 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312069&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880229 104146430 CHEMBL1076541 ZINC49946888 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561827 Fc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccnc2c(cnn12)-c1cn[nH]c1 InChI=1S/C23H14F4N6O/c24-19-5-4-16(32-22(34)13-2-1-3-15(8-13)23(25,26)27)9-17(19)20-6-7-28-21-18(12-31-33(20)21)14-10-29-30-11-14/h1-12H,(H,29,30)(H,32,34) AHQVZQVSHSOLDM-UHFFFAOYSA-N 50312070 CHEMBL1080438::N-(3-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-4-fluorophenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 18 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312070&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879460 104146431 CHEMBL1080438 ZINC49785407 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561828 FC(F)(F)c1cccc(c1)C(=O)Nc1ccc(Cl)c(c1)-c1ccnc2c(cnn12)-c1cn[nH]c1 InChI=1S/C23H14ClF3N6O/c24-19-5-4-16(32-22(34)13-2-1-3-15(8-13)23(25,26)27)9-17(19)20-6-7-28-21-18(12-31-33(20)21)14-10-29-30-11-14/h1-12H,(H,29,30)(H,32,34) RQGLQNLOJSOQJU-UHFFFAOYSA-N 50312071 CHEMBL1080439::N-(3-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-4-chlorophenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 42 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312071&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879458 104146432 CHEMBL1080439 ZINC49033171 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561829 COc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccnc2c(cnn12)-c1cn[nH]c1 InChI=1S/C24H17F3N6O2/c1-35-21-6-5-17(32-23(34)14-3-2-4-16(9-14)24(25,26)27)10-18(21)20-7-8-28-22-19(13-31-33(20)22)15-11-29-30-12-15/h2-13H,1H3,(H,29,30)(H,32,34) QEEYCINITWXPKV-UHFFFAOYSA-N 50312072 CHEMBL1080437::N-(3-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-4-methoxyphenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 98 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312072&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879459 104146433 CHEMBL1080437 ZINC49033091 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50561830 CN1CCN(CC1)c1ccc(cn1)-c1cnn2c(ccnc12)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1F InChI=1S/C30H25F4N7O/c1-39-11-13-40(14-12-39)27-8-5-20(17-36-27)24-18-37-41-26(9-10-35-28(24)41)23-16-22(6-7-25(23)31)38-29(42)19-3-2-4-21(15-19)30(32,33)34/h2-10,15-18H,11-14H2,1H3,(H,38,42) PIGVLAUTQMIRBH-UHFFFAOYSA-N 50312073 CHEMBL1076204::N-(4-fluoro-3-(3-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 30 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312073&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46879461 104146434 CHEMBL1076204 ZINC49777801 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50570672 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1cccnc1 InChI=1S/C25H16F3N5O/c26-25(27,28)19-7-1-5-17(12-19)24(34)31-20-8-2-4-16(13-20)22-9-11-30-23-14-21(32-33(22)23)18-6-3-10-29-15-18/h1-15H,(H,31,34) HWXNOWYUIGQFRY-UHFFFAOYSA-N 50314052 CHEMBL1091500::N-(3-(2-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2010.03.030 10.7270/Q29023ZZ 20307980 Gopalsamy, A; Shi, M; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314052&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883569 104148413 CHEMBL1091500 ZINC49113209 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50570673 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccncc1 InChI=1S/C25H16F3N5O/c26-25(27,28)19-5-1-4-18(13-19)24(34)31-20-6-2-3-17(14-20)22-9-12-30-23-15-21(32-33(22)23)16-7-10-29-11-8-16/h1-15H,(H,31,34) LCMNWMABPDVIPG-UHFFFAOYSA-N 50314051 CHEMBL1089082::N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 32 ChEMBL 10.1016/j.bmcl.2010.03.030 10.7270/Q29023ZZ 20307980 Gopalsamy, A; Shi, M; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314051&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24822704 104148412 CHEMBL1089082 ZINC49068339 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50570674 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ncnc2cc(sc12)-c1cccnc1 InChI=1S/C25H15F3N4OS/c26-25(27,28)18-7-1-5-16(10-18)24(33)32-19-8-2-4-15(11-19)22-23-20(30-14-31-22)12-21(34-23)17-6-3-9-29-13-17/h1-14H,(H,32,33) AZHSYTBMRGLCFB-UHFFFAOYSA-N 50315649 CHEMBL1090803::N-(3-(6-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2010.03.030 10.7270/Q29023ZZ 20307980 Gopalsamy, A; Shi, M; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315649&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46885361 104150010 CHEMBL1090803 ZINC49070599 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50570675 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ncnc2cc(sc12)-c1ccncc1 InChI=1S/C25H15F3N4OS/c26-25(27,28)18-5-1-4-17(11-18)24(33)32-19-6-2-3-16(12-19)22-23-20(30-14-31-22)13-21(34-23)15-7-9-29-10-8-15/h1-14H,(H,32,33) DPICQDOLUUWSST-UHFFFAOYSA-N 50315650 CHEMBL1090804::N-(3-(6-(pyridin-4-yl)thieno[3,2-d]pyrimidin-4-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 540 ChEMBL 10.1016/j.bmcl.2010.03.030 10.7270/Q29023ZZ 20307980 Gopalsamy, A; Shi, M; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315650&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46885362 104150011 CHEMBL1090804 ZINC49114851 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50570676 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ncnc2sc(cc12)-c1cccnc1 InChI=1S/C25H15F3N4OS/c26-25(27,28)18-7-1-5-16(10-18)23(33)32-19-8-2-4-15(11-19)22-20-12-21(17-6-3-9-29-13-17)34-24(20)31-14-30-22/h1-14H,(H,32,33) ONKHSMLRFXSPJU-UHFFFAOYSA-N 50315651 CHEMBL1093588::N-(3-(6-(pyridin-3-yl)thieno[2,3-d]pyrimidin-4-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 1110 ChEMBL 10.1016/j.bmcl.2010.03.030 10.7270/Q29023ZZ 20307980 Gopalsamy, A; Shi, M; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315651&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46885363 104150012 CHEMBL1093588 ZINC49113003 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50570677 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ncnc2sc(cc12)-c1ccncc1 InChI=1S/C25H15F3N4OS/c26-25(27,28)18-5-1-4-17(11-18)23(33)32-19-6-2-3-16(12-19)22-20-13-21(15-7-9-29-10-8-15)34-24(20)31-14-30-22/h1-14H,(H,32,33) CXIYVOOQCNGGIB-UHFFFAOYSA-N 50315652 CHEMBL1090143::N-(3-(6-(pyridin-4-yl)thieno[2,3-d]pyrimidin-4-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 80 ChEMBL 10.1016/j.bmcl.2010.03.030 10.7270/Q29023ZZ 20307980 Gopalsamy, A; Shi, M; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315652&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46865419 104150013 CHEMBL1090143 ZINC43205196 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50570678 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1c(cnc2cc(sc12)-c1cccnc1)C#N InChI=1S/C27H15F3N4OS/c28-27(29,30)20-7-1-5-17(10-20)26(35)34-21-8-2-4-16(11-21)24-19(13-31)15-33-22-12-23(36-25(22)24)18-6-3-9-32-14-18/h1-12,14-15H,(H,34,35) DYFSCGWRNGJIHE-UHFFFAOYSA-N 50315653 CHEMBL1090144::N-(3-(6-cyano-2-(pyridin-3-yl)thieno[3,2-b]pyridin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2010.03.030 10.7270/Q29023ZZ 20307980 Gopalsamy, A; Shi, M; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315653&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46885411 104150014 CHEMBL1090144 ZINC49068235 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50570679 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1c(cnc2cc(sc12)-c1ccncc1)C#N InChI=1S/C27H15F3N4OS/c28-27(29,30)20-5-1-4-18(11-20)26(35)34-21-6-2-3-17(12-21)24-19(14-31)15-33-22-13-23(36-25(22)24)16-7-9-32-10-8-16/h1-13,15H,(H,34,35) PYVCKVQHWLDFEY-UHFFFAOYSA-N 50315654 CHEMBL1091543::N-(3-(6-cyano-2-(pyridin-4-yl)thieno[3,2-b]pyridin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 5940 ChEMBL 10.1016/j.bmcl.2010.03.030 10.7270/Q29023ZZ 20307980 Gopalsamy, A; Shi, M; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315654&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 42606902 104150015 CHEMBL1091543 ZINC49113795 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50570680 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1c(cnc2sc(cc12)-c1cccnc1)C#N InChI=1S/C27H15F3N4OS/c28-27(29,30)20-7-1-5-17(10-20)25(35)34-21-8-2-4-16(11-21)24-19(13-31)15-33-26-22(24)12-23(36-26)18-6-3-9-32-14-18/h1-12,14-15H,(H,34,35) YBBFUABHNZIITH-UHFFFAOYSA-N 50315655 CHEMBL1091544::N-(3-(5-cyano-2-(pyridin-3-yl)thieno[2,3-b]pyridin-4-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2010.03.030 10.7270/Q29023ZZ 20307980 Gopalsamy, A; Shi, M; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315655&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46885412 104150016 CHEMBL1091544 ZINC49070306 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50570681 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1c(cnc2sc(cc12)-c1ccncc1)C#N InChI=1S/C27H15F3N4OS/c28-27(29,30)20-5-1-4-18(11-20)25(35)34-21-6-2-3-17(12-21)24-19(14-31)15-33-26-22(24)13-23(36-26)16-7-9-32-10-8-16/h1-13,15H,(H,34,35) DCSQNEAQWQRXLQ-UHFFFAOYSA-N 50315656 CHEMBL1091522::N-(3-(5-cyano-2-(pyridin-4-yl)thieno[2,3-b]pyridin-4-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2010.03.030 10.7270/Q29023ZZ 20307980 Gopalsamy, A; Shi, M; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315656&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46885477 104150017 CHEMBL1091522 ZINC49087687 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566457 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1cccc(c1)C(F)(F)F InChI=1S/C27H16F6N4O/c28-26(29,30)19-7-1-4-16(12-19)22-15-24-34-11-10-23(37(24)36-22)17-5-3-9-21(14-17)35-25(38)18-6-2-8-20(13-18)27(31,32)33/h1-15H,(H,35,38) FECZQYKCIHTMRD-UHFFFAOYSA-N 50314046 3-(trifluoromethyl)-N-(3-(2-(3-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)benzamide::CHEMBL1092538 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314046&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883538 104148407 CHEMBL1092538 ZINC49781402 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566458 COc1ccc(cc1)-c1cc2nccc(-c3cccc(NC(=O)c4cccc(c4)C(F)(F)F)c3)n2n1 InChI=1S/C27H19F3N4O2/c1-36-22-10-8-17(9-11-22)23-16-25-31-13-12-24(34(25)33-23)18-4-3-7-21(15-18)32-26(35)19-5-2-6-20(14-19)27(28,29)30/h2-16H,1H3,(H,32,35) FTGBLGHQTZGNMH-UHFFFAOYSA-N 50314047 CHEMBL1089412::N-(3-(2-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314047&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883535 104148408 CHEMBL1089412 ZINC49068022 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566459 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1cccs1 InChI=1S/C24H15F3N4OS/c25-24(26,27)17-6-1-5-16(12-17)23(32)29-18-7-2-4-15(13-18)20-9-10-28-22-14-19(30-31(20)22)21-8-3-11-33-21/h1-14H,(H,29,32) ARMKBDOVOBCACP-UHFFFAOYSA-N 50314048 CHEMBL1089410::N-(3-(2-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314048&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883533 104148409 CHEMBL1089410 ZINC49067872 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566460 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1c[nH]cn1 InChI=1S/C23H15F3N6O/c24-23(25,26)16-5-1-4-15(9-16)22(33)30-17-6-2-3-14(10-17)20-7-8-28-21-11-18(31-32(20)21)19-12-27-13-29-19/h1-13H,(H,27,29)(H,30,33) LIPAUKCKCNPBQQ-UHFFFAOYSA-N 50314049 CHEMBL1089411::N-(3-(2-(1H-imidazol-5-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 1600 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314049&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883534 104148410 CHEMBL1089411 ZINC49067874 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566461 Cn1cncc1-c1cc2nccc(-c3cccc(NC(=O)c4cccc(c4)C(F)(F)F)c3)n2n1 InChI=1S/C24H17F3N6O/c1-32-14-28-13-21(32)19-12-22-29-9-8-20(33(22)31-19)15-4-3-7-18(11-15)30-23(34)16-5-2-6-17(10-16)24(25,26)27/h2-14H,1H3,(H,30,34) LCQRBHGZPAFKKF-UHFFFAOYSA-N 50314050 CHEMBL1088768::N-(3-(2-(1-methyl-1H-imidazol-5-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314050&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883539 104148411 CHEMBL1088768 ZINC49068318 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566462 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccncc1 InChI=1S/C25H16F3N5O/c26-25(27,28)19-5-1-4-18(13-19)24(34)31-20-6-2-3-17(14-20)22-9-12-30-23-15-21(32-33(22)23)16-7-10-29-11-8-16/h1-15H,(H,31,34) LCMNWMABPDVIPG-UHFFFAOYSA-N 50314051 CHEMBL1089082::N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 32 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314051&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24822704 104148412 CHEMBL1089082 ZINC49068339 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566463 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1cccnc1 InChI=1S/C25H16F3N5O/c26-25(27,28)19-7-1-5-17(12-19)24(34)31-20-8-2-4-16(13-20)22-9-11-30-23-14-21(32-33(22)23)18-6-3-10-29-15-18/h1-15H,(H,31,34) HWXNOWYUIGQFRY-UHFFFAOYSA-N 50314052 CHEMBL1091500::N-(3-(2-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314052&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883569 104148413 CHEMBL1091500 ZINC49113209 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566464 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)N1CCNCC1 InChI=1S/C24H21F3N6O/c25-24(26,27)18-5-1-4-17(13-18)23(34)30-19-6-2-3-16(14-19)20-7-8-29-21-15-22(31-33(20)21)32-11-9-28-10-12-32/h1-8,13-15,28H,9-12H2,(H,30,34) BYYUAHCUHJMTHJ-UHFFFAOYSA-N 50314053 CHEMBL1092827::N-(3-(2-(piperazin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 6200 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314053&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883570 104148414 CHEMBL1092827 ZINC49072778 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566465 CN1CCN(CC1)c1cc2nccc(-c3cccc(NC(=O)c4cccc(c4)C(F)(F)F)c3)n2n1 InChI=1S/C25H23F3N6O/c1-32-10-12-33(13-11-32)23-16-22-29-9-8-21(34(22)31-23)17-4-3-7-20(15-17)30-24(35)18-5-2-6-19(14-18)25(26,27)28/h2-9,14-16H,10-13H2,1H3,(H,30,35) IVFOMDILWVRNQN-UHFFFAOYSA-N 50314054 CHEMBL1093104::N-(3-(2-(4-methylpiperazin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314054&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883571 104148415 CHEMBL1093104 ZINC49113566 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566466 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)N1CCOCC1 InChI=1S/C24H20F3N5O2/c25-24(26,27)18-5-1-4-17(13-18)23(33)29-19-6-2-3-16(14-19)20-7-8-28-21-15-22(30-32(20)21)31-9-11-34-12-10-31/h1-8,13-15H,9-12H2,(H,29,33) CSBJRBYRFSOSAV-UHFFFAOYSA-N 50314055 CHEMBL1093105::N-(3-(2-morpholinopyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 99 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314055&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24768568 104148416 CHEMBL1093105 ZINC49072792 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566467 Clc1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccncc1 InChI=1S/C24H16ClN5O/c25-19-5-1-4-18(13-19)24(31)28-20-6-2-3-17(14-20)22-9-12-27-23-15-21(29-30(22)23)16-7-10-26-11-8-16/h1-15H,(H,28,31) XOPKUUJHGXTLIH-UHFFFAOYSA-N 50314056 3-chloro-N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)benzamide::CHEMBL1089751 Serine/threonine-protein kinase B-raf Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314056&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883708 104148417 CHEMBL1089751 ZINC49055565 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566468 COc1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccncc1 InChI=1S/C25H19N5O2/c1-32-21-7-3-5-19(15-21)25(31)28-20-6-2-4-18(14-20)23-10-13-27-24-16-22(29-30(23)24)17-8-11-26-12-9-17/h2-16H,1H3,(H,28,31) YVFZEXDTSJHDSK-UHFFFAOYSA-N 50314057 3-methoxy-N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)benzamide::CHEMBL1090081 Serine/threonine-protein kinase B-raf Homo sapiens 4000 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314057&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883709 104148418 CHEMBL1090081 ZINC49112131 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566469 Clc1ccc(cc1Cl)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccncc1 InChI=1S/C24H15Cl2N5O/c25-19-5-4-17(13-20(19)26)24(32)29-18-3-1-2-16(12-18)22-8-11-28-23-14-21(30-31(22)23)15-6-9-27-10-7-15/h1-14H,(H,29,32) HZKVQTZSYHOKCL-UHFFFAOYSA-N 50314058 3,4-dichloro-N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)benzamide::CHEMBL1090082 Serine/threonine-protein kinase B-raf Homo sapiens 660 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314058&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883710 104148419 CHEMBL1090082 ZINC49067267 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566470 FC(F)(F)c1cc(ccc1Cl)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccncc1 InChI=1S/C25H15ClF3N5O/c26-20-5-4-17(13-19(20)25(27,28)29)24(35)32-18-3-1-2-16(12-18)22-8-11-31-23-14-21(33-34(22)23)15-6-9-30-10-7-15/h1-14H,(H,32,35) NAZBCPATAWKFPO-UHFFFAOYSA-N 50314059 4-chloro-N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide::CHEMBL1090083 Serine/threonine-protein kinase B-raf Homo sapiens 60 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314059&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883711 104148420 CHEMBL1090083 ZINC49067269 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566471 FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2ccnc3cc(nn23)-c2ccncc2)c1 InChI=1S/C25H17F3N6O/c26-25(27,28)18-4-2-6-20(14-18)32-24(35)31-19-5-1-3-17(13-19)22-9-12-30-23-15-21(33-34(22)23)16-7-10-29-11-8-16/h1-15H,(H2,31,32,35) MJVDIICPSKNKLF-UHFFFAOYSA-N 50314060 1-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea::CHEMBL1091843 Serine/threonine-protein kinase B-raf Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314060&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883714 104148421 CHEMBL1091843 ZINC49072359 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566472 FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)-c2ccnc3cc(nn23)-c2ccncc2)ccc1Cl InChI=1S/C25H16ClF3N6O/c26-20-5-4-18(13-19(20)25(27,28)29)33-24(36)32-17-3-1-2-16(12-17)22-8-11-31-23-14-21(34-35(22)23)15-6-9-30-10-7-15/h1-14H,(H2,32,33,36) KZNGWXWPVOLSQU-UHFFFAOYSA-N 50314061 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)urea::CHEMBL1091844 Serine/threonine-protein kinase B-raf Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314061&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883715 104148422 CHEMBL1091844 ZINC49072685 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566473 CN(C)CCNc1cc(ccn1)-c1cc2nccc(-c3cccc(NC(=O)c4cccc(c4)C(F)(F)F)c3)n2n1 InChI=1S/C29H26F3N7O/c1-38(2)14-13-34-26-17-19(9-11-33-26)24-18-27-35-12-10-25(39(27)37-24)20-5-4-8-23(16-20)36-28(40)21-6-3-7-22(15-21)29(30,31)32/h3-12,15-18H,13-14H2,1-2H3,(H,33,34)(H,36,40) JJZMISIQDYXLAI-UHFFFAOYSA-N 50314062 CHEMBL1092180::N-(3-(2-(2-(2-(dimethylamino)ethylamino)pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 53 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314062&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883716 104148423 CHEMBL1092180 ZINC49781294 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566474 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccnc(NCCN2CCOCC2)c1 InChI=1S/C31H28F3N7O2/c32-31(33,34)24-5-1-4-23(17-24)30(42)38-25-6-2-3-22(18-25)27-8-10-37-29-20-26(39-41(27)29)21-7-9-35-28(19-21)36-11-12-40-13-15-43-16-14-40/h1-10,17-20H,11-16H2,(H,35,36)(H,38,42) ISCYINUUKSFOIW-UHFFFAOYSA-N 50314063 CHEMBL1091684::N-(3-(2-(2-(2-morpholinoethylamino)pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314063&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883717 104148424 CHEMBL1091684 ZINC49781093 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566475 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccnc(NCCCN2CCOCC2)c1 InChI=1S/C32H30F3N7O2/c33-32(34,35)25-6-1-5-24(18-25)31(43)39-26-7-2-4-23(19-26)28-9-12-38-30-21-27(40-42(28)30)22-8-11-37-29(20-22)36-10-3-13-41-14-16-44-17-15-41/h1-2,4-9,11-12,18-21H,3,10,13-17H2,(H,36,37)(H,39,43) FJHJWHQDODDFAU-UHFFFAOYSA-N 50314064 CHEMBL1091685::N-(3-(2-(2-(3-morpholinopropylamino)pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314064&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883718 104148425 CHEMBL1091685 ZINC49780596 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566476 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccnc(NCCN2CCCC2)c1 InChI=1S/C31H28F3N7O/c32-31(33,34)24-7-3-6-23(17-24)30(42)38-25-8-4-5-22(18-25)27-10-12-37-29-20-26(39-41(27)29)21-9-11-35-28(19-21)36-13-16-40-14-1-2-15-40/h3-12,17-20H,1-2,13-16H2,(H,35,36)(H,38,42) IQTMKKLAPIHCBO-UHFFFAOYSA-N 50314065 CHEMBL1091686::N-(3-(2-(2-(2-(pyrrolidin-1-yl)ethylamino)pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 68 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314065&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883719 104148426 CHEMBL1091686 ZINC49793725 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566477 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccnc(NCCCN2CCCC2)c1 InChI=1S/C32H30F3N7O/c33-32(34,35)25-8-3-7-24(18-25)31(43)39-26-9-4-6-23(19-26)28-11-14-38-30-21-27(40-42(28)30)22-10-13-37-29(20-22)36-12-5-17-41-15-1-2-16-41/h3-4,6-11,13-14,18-21H,1-2,5,12,15-17H2,(H,36,37)(H,39,43) NRHIJVYWTBCVNR-UHFFFAOYSA-N 50314066 CHEMBL1091687::N-(3-(2-(2-(3-(pyrrolidin-1-yl)propylamino)pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 110 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314066&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883720 104148427 CHEMBL1091687 ZINC49802205 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566478 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccnc(NCCCN2CCCC2=O)c1 InChI=1S/C32H28F3N7O2/c33-32(34,35)24-7-1-6-23(17-24)31(44)39-25-8-2-5-22(18-25)27-11-14-38-29-20-26(40-42(27)29)21-10-13-37-28(19-21)36-12-4-16-41-15-3-9-30(41)43/h1-2,5-8,10-11,13-14,17-20H,3-4,9,12,15-16H2,(H,36,37)(H,39,44) YAMWVJGVIAAELZ-UHFFFAOYSA-N 50314067 CHEMBL1091688::N-(3-(2-(2-(3-(2-oxopyrrolidin-1-yl)propylamino)pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 110 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314067&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883721 104148428 CHEMBL1091688 ZINC49781094 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566479 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccnc(NCCCc2ncc[nH]2)c1 InChI=1S/C31H25F3N8O/c32-31(33,34)23-6-1-5-22(16-23)30(43)40-24-7-2-4-21(17-24)26-10-13-39-29-19-25(41-42(26)29)20-9-12-36-28(18-20)35-11-3-8-27-37-14-15-38-27/h1-2,4-7,9-10,12-19H,3,8,11H2,(H,35,36)(H,37,38)(H,40,43) UVOURMTZWAHXDG-UHFFFAOYSA-N 50314068 CHEMBL1091689::N-(3-(2-(2-(3-(1H-imidazol-2-yl)propylamino)pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 66 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314068&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883722 104148429 CHEMBL1091689 ZINC49793277 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50566480 OC1CCN(CCNc2cc(ccn2)-c2cc3nccc(-c4cccc(NC(=O)c5cccc(c5)C(F)(F)F)c4)n3n2)CC1 InChI=1S/C32H30F3N7O2/c33-32(34,35)24-5-1-4-23(17-24)31(44)39-25-6-2-3-22(18-25)28-8-12-38-30-20-27(40-42(28)30)21-7-11-36-29(19-21)37-13-16-41-14-9-26(43)10-15-41/h1-8,11-12,17-20,26,43H,9-10,13-16H2,(H,36,37)(H,39,44) VTMCXPIYMFDLKI-UHFFFAOYSA-N 50314069 CHEMBL1091690::N-(3-(2-(2-(2-(4-hydroxypiperidin-1-yl)ethylamino)pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 66 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314069&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46883723 104148430 CHEMBL1091690 ZINC49781095 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50596989 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 540 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50595836 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50589682 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Serine/threonine-protein kinase B-raf Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2010.05.063 10.7270/Q2HQ403C 20621496 Dietrich, J; Hulme, C; Hurley, LH The University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50589683 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 76.2 ChEMBL 10.1016/j.bmc.2010.05.063 10.7270/Q2HQ403C 20621496 Dietrich, J; Hulme, C; Hurley, LH The University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50589684 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Serine/threonine-protein kinase B-raf Homo sapiens 83.4 ChEMBL 10.1016/j.bmc.2010.05.063 10.7270/Q2HQ403C 20621496 Dietrich, J; Hulme, C; Hurley, LH The University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50589685 CNC(=O)c1cc(Oc2ccc(NC(=O)c3ccc(CN4CCN(C)CC4)cc3)cc2)ccn1 InChI=1S/C26H29N5O3/c1-27-26(33)24-17-23(11-12-28-24)34-22-9-7-21(8-10-22)29-25(32)20-5-3-19(4-6-20)18-31-15-13-30(2)14-16-31/h3-12,17H,13-16,18H2,1-2H3,(H,27,33)(H,29,32) VQIBSZYZJIEVJB-UHFFFAOYSA-N 50323915 CHEMBL1213922::N-methyl-4-(4-(4-((4-methylpiperazin-1-yl)methyl)benzamido)phenoxy)picolinamide Serine/threonine-protein kinase B-raf Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2010.05.063 10.7270/Q2HQ403C 20621496 Dietrich, J; Hulme, C; Hurley, LH The University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323915&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49863686 117645236 CHEMBL1213922 ZINC58563960 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50589686 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)CC1 InChI=1S/C29H36N4O3/c1-31-12-14-33(15-13-31)22-23-6-8-24(9-7-23)29(34)30-27-10-11-28(26-5-3-2-4-25(26)27)36-21-18-32-16-19-35-20-17-32/h2-11H,12-22H2,1H3,(H,30,34) XIWBIVHGXQNDRO-UHFFFAOYSA-N 50323916 4-((4-methylpiperazin-1-yl)methyl)-N-(4-(2-morpholinoethoxy)naphthalen-1-yl)benzamide::CHEMBL1213923 Serine/threonine-protein kinase B-raf Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2010.05.063 10.7270/Q2HQ403C 20621496 Dietrich, J; Hulme, C; Hurley, LH The University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323916&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49863687 117645237 CHEMBL1213923 ZINC58563907 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50589687 Cc1ccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cc1Nc1nccc(n1)-c1cccnc1 InChI=1S/C24H18ClF3N6O/c1-14-4-5-17(32-23(35)31-16-6-7-19(25)18(11-16)24(26,27)28)12-21(14)34-22-30-10-8-20(33-22)15-3-2-9-29-13-15/h2-13H,1H3,(H,30,33,34)(H2,31,32,35) VZONEKWHHXKRRX-UHFFFAOYSA-N 50323922 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)urea::CHEMBL1213924 Serine/threonine-protein kinase B-raf Homo sapiens 180.1 ChEMBL 10.1016/j.bmc.2010.05.063 10.7270/Q2HQ403C 20621496 Dietrich, J; Hulme, C; Hurley, LH The University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323922&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46919120 117645243 CHEMBL1213924 ZINC58563804 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50589688 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1)C(C)(C)C InChI=1S/C31H32N8O/c1-20-8-12-24(13-9-20)39-28(18-27(38-39)31(3,4)5)37-30(40)34-23-11-10-21(2)26(17-23)36-29-33-16-14-25(35-29)22-7-6-15-32-19-22/h6-19H,1-5H3,(H,33,35,36)(H2,34,37,40) BBZXKDAPACZAMH-UHFFFAOYSA-N 50323918 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)urea::CHEMBL1213973 Serine/threonine-protein kinase B-raf Homo sapiens 413.9 ChEMBL 10.1016/j.bmc.2010.05.063 10.7270/Q2HQ403C 20621496 Dietrich, J; Hulme, C; Hurley, LH The University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323918&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46919122 117645239 CHEMBL1213973 ZINC58547907 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50589689 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)cc2)ccn1 InChI=1S/C28H30N6O3/c1-18-6-10-20(11-7-18)34-25(17-24(33-34)28(2,3)4)32-27(36)31-19-8-12-21(13-9-19)37-22-14-15-30-23(16-22)26(35)29-5/h6-17H,1-5H3,(H,29,35)(H2,31,32,36) HOHLGEPKIHZUGO-UHFFFAOYSA-N 50323919 4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)phenoxy)-N-methylpicolinamide::CHEMBL1213974 Serine/threonine-protein kinase B-raf Homo sapiens 236.7 ChEMBL 10.1016/j.bmc.2010.05.063 10.7270/Q2HQ403C 20621496 Dietrich, J; Hulme, C; Hurley, LH The University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323919&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11947957 117645240 CHEMBL1213974 ZINC36518249 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50589690 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(CN4CCN(C)CC4)cc3)cc2)ccn1 InChI=1S/C26H30N6O3/c1-27-25(33)24-17-23(11-12-28-24)35-22-9-7-21(8-10-22)30-26(34)29-20-5-3-19(4-6-20)18-32-15-13-31(2)14-16-32/h3-12,17H,13-16,18H2,1-2H3,(H,27,33)(H2,29,30,34) RQLWMLCETYOBRR-UHFFFAOYSA-N 50323920 CHEMBL1213975::N-methyl-4-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)phenyl)ureido)phenoxy)picolinamide Serine/threonine-protein kinase B-raf Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2010.05.063 10.7270/Q2HQ403C 20621496 Dietrich, J; Hulme, C; Hurley, LH The University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323920&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49863710 117645241 CHEMBL1213975 ZINC58564052 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50589691 FC(F)(F)c1cc(NC(=O)Nc2ccc(OCCN3CCOCC3)cc2)ccc1Cl InChI=1S/C20H21ClF3N3O3/c21-18-6-3-15(13-17(18)20(22,23)24)26-19(28)25-14-1-4-16(5-2-14)30-12-9-27-7-10-29-11-8-27/h1-6,13H,7-12H2,(H2,25,26,28) CYTGCHOMPXDYOU-UHFFFAOYSA-N 50323921 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-(2-morpholinoethoxy)phenyl)urea::CHEMBL1213976 Serine/threonine-protein kinase B-raf Homo sapiens 92.3 ChEMBL 10.1016/j.bmc.2010.05.063 10.7270/Q2HQ403C 20621496 Dietrich, J; Hulme, C; Hurley, LH The University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323921&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49863711 117645242 CHEMBL1213976 ZINC58564026 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50596086 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4[C@H](O)NC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31,33,41H,17H2,1-3H3,(H,36,40)/t23-,24-,31-,33+,35+/m1/s1 ZZSBPGIGIUFJRA-AKIDMACVSA-N 50326054 CHEMBL1240703 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326054&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52945601 123105169 CHEMBL1240703 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50594545 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 22 ChEMBL 10.1038/nchembio799 10.7270/Q2CC10WV 16783341 Liu, Y; Gray, NS Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50596147 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50603966 CC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)n(n1)-c1cccc(CC(N)=O)c1 InChI=1S/C22H23Cl2N5O2/c1-22(2,3)17-12-19(27-21(31)26-16-9-5-8-15(23)20(16)24)29(28-17)14-7-4-6-13(10-14)11-18(25)30/h4-10,12H,11H2,1-3H3,(H2,25,30)(H2,26,27,31) ZJQYVSTVRXOFQL-UHFFFAOYSA-N 50328755 2-(3-(3-tert-butyl-5-(3-(2,3-dichlorophenyl)ureido)-1H-pyrazol-1-yl)phenyl)acetamide::CHEMBL1271376 Serine/threonine-protein kinase B-raf Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2010.07.134 10.7270/Q2XD11WK 20800479 Ahn, YM; Clare, M; Ensinger, CL; Hood, MM; Lord, JW; Lu, WP; Miller, DF; Patt, WC; Smith, BD; Vogeti, L; Kaufman, MD; Petillo, PA; Wise, SC; Abendroth, J; Chun, L; Clark, R; Feese, M; Kim, H; Stewart, L; Flynn, DL Deciphera Pharmaceuticals LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50328755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50328755&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46870033 123107870 CHEMBL1271376 ZINC58655575 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50600019 Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)c(F)c3)c12 InChI=1S/C21H15F4N5O2/c1-30-8-7-17-18(30)19(27-11-26-17)32-14-5-6-16(15(22)10-14)29-20(31)28-13-4-2-3-12(9-13)21(23,24)25/h2-11H,1H3,(H2,28,29,31) TWOLOZGQZKJZKJ-UHFFFAOYSA-N 50327046 1-(2-fluoro-4-(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea::1-{2-Fluoro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-oxy]phenyl}-3-[3-(trifluoromethyl)phenyl]urea::CHEMBL1254007::D3RKN_16 Serine/threonine-protein kinase B-raf Homo sapiens 900 ChEMBL 10.1016/j.bmc.2010.08.017 10.7270/Q2NC61DC 20833055 Oguro, Y; Miyamoto, N; Okada, K; Takagi, T; Iwata, H; Awazu, Y; Miki, H; Hori, A; Kamiyama, K; Imamura, S Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50327046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50327046&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 42Q 3VHE 15949613 123106161 CHEMBL1254007 ZINC34802749 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50595063 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609098 CN1C[C@@H]2C[C@H]1CN2c1cccc(c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C30H26N8/c1-36-17-23-15-22(36)18-37(23)21-5-2-4-20(14-21)27-10-13-32-30-28(24-6-3-7-26-25(24)16-33-34-26)29(35-38(27)30)19-8-11-31-12-9-19/h2-14,16,22-23H,15,17-18H2,1H3,(H,33,34)/t22-,23-/m0/s1 JAOWPXRBRZGFTN-GOTSBHOMSA-N 50330902 3-(1H-indazol-4-yl)-7-(3-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276968 Serine/threonine-protein kinase B-raf Homo sapiens 61 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330902&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836856 123110017 CHEMBL1276968 ZINC64447203 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609099 C(N1C[C@@H]2C[C@H]1CO2)c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C30H25N7O/c1-2-24(25-15-33-34-26(25)3-1)28-29(21-8-11-31-12-9-21)35-37-27(10-13-32-30(28)37)20-6-4-19(5-7-20)16-36-17-23-14-22(36)18-38-23/h1-13,15,22-23H,14,16-18H2,(H,33,34)/t22-,23-/m0/s1 ZSNSAQOQPACNET-GOTSBHOMSA-N 50330903 (1S,4S)-5-(4-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)benzyl)-2-oxa-5-azabicyclo[2.2.1]heptane::CHEMBL1277056 Serine/threonine-protein kinase B-raf Homo sapiens 10 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330903&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49837088 123110018 CHEMBL1277056 ZINC64453975 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609100 CN1C[C@@H]2C[C@H]1CN2c1c(F)cc(cc1F)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C30H24F2N8/c1-38-15-20-13-19(38)16-39(20)29-23(31)11-18(12-24(29)32)26-7-10-34-30-27(21-3-2-4-25-22(21)14-35-36-25)28(37-40(26)30)17-5-8-33-9-6-17/h2-12,14,19-20H,13,15-16H2,1H3,(H,35,36)/t19-,20-/m0/s1 BVVMYZVXLZHYKF-PMACEKPBSA-N 50330904 7-(3,5-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276180 Serine/threonine-protein kinase B-raf Homo sapiens 9.6 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330904&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836750 123110019 CHEMBL1276180 ZINC64453994 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609102 CN(C)c1cc(ccc1-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12)N1C[C@@H]2C[C@H]1CN2C InChI=1S/C32H31N9/c1-38(2)29-16-21(40-19-22-15-23(40)18-39(22)3)7-8-25(29)28-11-14-34-32-30(24-5-4-6-27-26(24)17-35-36-27)31(37-41(28)32)20-9-12-33-13-10-20/h4-14,16-17,22-23H,15,18-19H2,1-3H3,(H,35,36)/t22-,23-/m0/s1 UFZTXENTOJCMRS-GOTSBHOMSA-N 50330906 2-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-N,N-dimethyl-5-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)aniline::CHEMBL1276173 Serine/threonine-protein kinase B-raf Homo sapiens 7.3 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330906&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836646 123110021 CHEMBL1276173 ZINC64453614 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609103 C(N1C[C@@H]2C[C@@H]1CN2)c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C30H26N8/c1-2-24(25-16-34-35-26(25)3-1)28-29(21-8-11-31-12-9-21)36-38-27(10-13-32-30(28)38)20-6-4-19(5-7-20)17-37-18-22-14-23(37)15-33-22/h1-13,16,22-23,33H,14-15,17-18H2,(H,34,35)/t22-,23+/m0/s1 IATPYRUMNQKRDI-XZOQPEGZSA-N 50330907 7-(4-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-ylmethyl)phenyl)-3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276191 Serine/threonine-protein kinase B-raf Homo sapiens 2.3 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330907&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91933603 123110022 CHEMBL1276191 ZINC64448608 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609104 CN1C[C@@H]2C[C@H]1CN2c1ccc(cc1C(F)(F)F)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C31H25F3N8/c1-40-16-21-14-20(40)17-41(21)27-6-5-19(13-24(27)31(32,33)34)26-9-12-36-30-28(22-3-2-4-25-23(22)15-37-38-25)29(39-42(26)30)18-7-10-35-11-8-18/h2-13,15,20-21H,14,16-17H2,1H3,(H,37,38)/t20-,21-/m0/s1 FVDQTDWBXKAMSI-SFTDATJTSA-N 50330908 3-(1H-indazol-4-yl)-7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)-3-(trifluoromethyl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276175 Serine/threonine-protein kinase B-raf Homo sapiens 2 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330908&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836648 123110023 CHEMBL1276175 ZINC64453801 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609105 CN1C[C@@H]2C[C@H]1CN2c1ccc(cc1F)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C30H25FN8/c1-37-16-21-14-20(37)17-38(21)27-6-5-19(13-24(27)31)26-9-12-33-30-28(22-3-2-4-25-23(22)15-34-35-25)29(36-39(26)30)18-7-10-32-11-8-18/h2-13,15,20-21H,14,16-17H2,1H3,(H,34,35)/t20-,21-/m0/s1 ZCAZCAFBWFZPCU-SFTDATJTSA-N 50330909 7-(3-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276174 Serine/threonine-protein kinase B-raf Homo sapiens 1.9 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330909&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836647 123110024 CHEMBL1276174 ZINC64453799 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609106 CN1C[C@@H]2C[C@H]1CC2c1cc(F)ccc1-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C31H26FN7/c1-38-17-19-13-21(38)15-24(19)25-14-20(32)5-6-22(25)28-9-12-34-31-29(23-3-2-4-27-26(23)16-35-36-27)30(37-39(28)31)18-7-10-33-11-8-18/h2-12,14,16,19,21,24H,13,15,17H2,1H3,(H,35,36)/t19-,21-,24?/m0/s1 TUDBQXAJQWDULL-GGGSXUAESA-N 50330910 7-(4-fluoro-2-((1R,4R)-2-methyl-2-azabicyclo[2.2.1]heptan-5-yl)phenyl)-3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276182 Serine/threonine-protein kinase B-raf Homo sapiens 1.4 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330910&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52950212 123110025 CHEMBL1276182 ZINC64448390 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609107 CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(c(nn23)-c2ccncc2)-c2cccc3[nH]ncc23)c(c1)C(F)(F)F InChI=1S/C31H25F3N8/c1-40-16-21-13-20(40)17-41(21)19-5-6-23(25(14-19)31(32,33)34)27-9-12-36-30-28(22-3-2-4-26-24(22)15-37-38-26)29(39-42(27)30)18-7-10-35-11-8-18/h2-12,14-15,20-21H,13,16-17H2,1H3,(H,37,38)/t20-,21-/m0/s1 FRBQGDYIANBVIV-SFTDATJTSA-N 50330911 3-(1H-indazol-4-yl)-7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-(trifluoromethyl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276172 Serine/threonine-protein kinase B-raf Homo sapiens 1.4 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330911&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836542 123110026 CHEMBL1276172 ZINC64453613 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609108 Fc1cc(CN2C[C@@H]3C[C@H]2CO3)ccc1-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C30H24FN7O/c31-25-12-18(15-37-16-21-13-20(37)17-39-21)4-5-23(25)27-8-11-33-30-28(22-2-1-3-26-24(22)14-34-35-26)29(36-38(27)30)19-6-9-32-10-7-19/h1-12,14,20-21H,13,15-17H2,(H,34,35)/t20-,21-/m0/s1 UEMMXLHHQNSAQG-SFTDATJTSA-N 50330912 (1S,4S)-5-(4-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-fluorobenzyl)-2-oxa-5-azabicyclo[2.2.1]heptane::CHEMBL1276189 Serine/threonine-protein kinase B-raf Homo sapiens 1.2 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330912&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49837089 123110027 CHEMBL1276189 ZINC64447091 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609109 CN1C[C@@H]2C[C@H]1CN2c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C30H26N8/c1-36-17-23-15-22(36)18-37(23)21-7-5-19(6-8-21)27-11-14-32-30-28(24-3-2-4-26-25(24)16-33-34-26)29(35-38(27)30)20-9-12-31-13-10-20/h2-14,16,22-23H,15,17-18H2,1H3,(H,33,34)/t22-,23-/m0/s1 PYJKVBOUWSBRRD-GOTSBHOMSA-N 50330913 3-(1H-indazol-4-yl)-7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1278218 Serine/threonine-protein kinase B-raf Homo sapiens 1.2 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330913&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52949635 123110028 CHEMBL1278218 ZINC64448382 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609110 CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(c(nn23)-c2ccncc2)-c2cccc3[nH]ncc23)c2ccccc12 InChI=1S/C34H28N8/c1-40-19-23-17-22(40)20-41(23)30-10-9-26(24-5-2-3-6-25(24)30)31-13-16-36-34-32(27-7-4-8-29-28(27)18-37-38-29)33(39-42(31)34)21-11-14-35-15-12-21/h2-16,18,22-23H,17,19-20H2,1H3,(H,37,38)/t22-,23-/m0/s1 FFURISGHTWLMMF-GOTSBHOMSA-N 50330914 3-(1H-indazol-4-yl)-7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthalen-1-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276176 Serine/threonine-protein kinase B-raf Homo sapiens 1 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330914&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836649 123110029 CHEMBL1276176 ZINC64448105 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609111 Fc1cc(CN2C3COCC2COC3)ccc1-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C31H26FN7O2/c32-26-12-19(14-38-21-15-40-17-22(38)18-41-16-21)4-5-24(26)28-8-11-34-31-29(23-2-1-3-27-25(23)13-35-36-27)30(37-39(28)31)20-6-9-33-10-7-20/h1-13,21-22H,14-18H2,(H,35,36) GXFJFRRQODZUEM-UHFFFAOYSA-N 50330915 9-(4-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-fluorobenzyl)-3,7-dioxa-9-azabicyclo[3.3.1]nonane::CHEMBL1276192 Serine/threonine-protein kinase B-raf Homo sapiens 0.770000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330915&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49837198 123110030 CHEMBL1276192 ZINC64448611 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609112 CN1C[C@@H]2CC[C@H]1CN2c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C31H28N8/c1-37-18-24-10-9-23(37)19-38(24)22-7-5-20(6-8-22)28-13-16-33-31-29(25-3-2-4-27-26(25)17-34-35-27)30(36-39(28)31)21-11-14-32-15-12-21/h2-8,11-17,23-24H,9-10,18-19H2,1H3,(H,34,35)/t23-,24-/m0/s1 DHOHJHINZMGEQL-ZEQRLZLVSA-N 50330916 (1S,4S)-2-(4-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-5-methyl-2,5-diazabicyclo[2.2.2]octane::CHEMBL1276187 Serine/threonine-protein kinase B-raf Homo sapiens 0.710000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330916&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836968 123110031 CHEMBL1276187 ZINC64447734 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609113 CN1C[C@@H]2C[C@H]1CN2c1ccc(c(F)c1F)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C30H24F2N8/c1-38-15-19-13-18(38)16-39(19)25-6-5-21(27(31)28(25)32)24-9-12-34-30-26(20-3-2-4-23-22(20)14-35-36-23)29(37-40(24)30)17-7-10-33-11-8-17/h2-12,14,18-19H,13,15-16H2,1H3,(H,35,36)/t18-,19-/m0/s1 XXUPDWIGWMMESL-OALUTQOASA-N 50330917 7-(2,3-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276177 Serine/threonine-protein kinase B-raf Homo sapiens 0.610000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330917&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836748 123110032 CHEMBL1276177 ZINC64453803 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609114 Fc1cc(CN2C[C@H]3C[C@@H]2CO3)ccc1-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C30H24FN7O/c31-25-12-18(15-37-16-21-13-20(37)17-39-21)4-5-23(25)27-8-11-33-30-28(22-2-1-3-26-24(22)14-34-35-26)29(36-38(27)30)19-6-9-32-10-7-19/h1-12,14,20-21H,13,15-17H2,(H,34,35)/t20-,21-/m1/s1 UEMMXLHHQNSAQG-NHCUHLMSSA-N 50330918 (1R,4R)-5-(4-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-fluorobenzyl)-2-oxa-5-azabicyclo[2.2.1]heptane::CHEMBL1276190 Serine/threonine-protein kinase B-raf Homo sapiens 0.520000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330918&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49837090 123110033 CHEMBL1276190 ZINC64447092 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609115 CN1C[C@@H]2C[C@H]1CN2c1ccc(c(C)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C31H28N8/c1-19-14-21(38-18-22-15-23(38)17-37(22)2)6-7-24(19)28-10-13-33-31-29(25-4-3-5-27-26(25)16-34-35-27)30(36-39(28)31)20-8-11-32-12-9-20/h3-14,16,22-23H,15,17-18H2,1-2H3,(H,34,35)/t22-,23-/m0/s1 OKXYKSQQZLCBJK-GOTSBHOMSA-N 50330919 3-(1H-indazol-4-yl)-7-(2-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276168 Serine/threonine-protein kinase B-raf Homo sapiens 0.510000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330919&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836427 123110034 CHEMBL1276168 ZINC64436753 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609116 CN1C[C@@H]2C[C@H]1CN2c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(F)c2[nH]ncc12 InChI=1S/C30H25FN8/c1-37-16-22-14-21(37)17-38(22)20-4-2-18(3-5-20)26-10-13-33-30-27(23-6-7-25(31)29-24(23)15-34-35-29)28(36-39(26)30)19-8-11-32-12-9-19/h2-13,15,21-22H,14,16-17H2,1H3,(H,34,35)/t21-,22-/m0/s1 OKZWPEYBUNXJRT-VXKWHMMOSA-N 50330920 3-(7-fluoro-1H-indazol-4-yl)-7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276183 Serine/threonine-protein kinase B-raf Homo sapiens 0.500000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330920&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836857 123110035 CHEMBL1276183 ZINC64448391 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609117 CN1C[C@@H]2CC[C@H]1CN2c1ccc(c(F)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C31H27FN8/c1-38-17-22-6-5-21(38)18-39(22)20-7-8-24(26(32)15-20)28-11-14-34-31-29(23-3-2-4-27-25(23)16-35-36-27)30(37-40(28)31)19-9-12-33-13-10-19/h2-4,7-16,21-22H,5-6,17-18H2,1H3,(H,35,36)/t21-,22-/m0/s1 AULMPUHJUBFVEB-VXKWHMMOSA-N 50330921 (1S,4S)-2-(4-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-fluorophenyl)-5-methyl-2,5-diazabicyclo[2.2.2]octane::CHEMBL1276188 Serine/threonine-protein kinase B-raf Homo sapiens 0.410000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330921&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49837087 123110036 CHEMBL1276188 ZINC64447949 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609118 CN1C[C@@H]2C[C@H]1CN2c1cc(F)c(cc1F)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C30H24F2N8/c1-38-15-19-11-18(38)16-39(19)27-13-23(31)21(12-24(27)32)26-7-10-34-30-28(20-3-2-4-25-22(20)14-35-36-25)29(37-40(26)30)17-5-8-33-9-6-17/h2-10,12-14,18-19H,11,15-16H2,1H3,(H,35,36)/t18-,19-/m0/s1 GOECJKFZTREFBV-OALUTQOASA-N 50330922 7-(2,5-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276178 Serine/threonine-protein kinase B-raf Homo sapiens 0.380000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330922&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836749 123110037 CHEMBL1276178 ZINC64453804 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609119 CN1C[C@@H]2C[C@H]1CN2c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc(O)c1 InChI=1S/C29H26N6O/c1-33-17-24-16-23(33)18-34(24)22-7-5-19(6-8-22)26-11-14-31-29-27(21-3-2-4-25(36)15-21)28(32-35(26)29)20-9-12-30-13-10-20/h2-15,23-24,36H,16-18H2,1H3/t23-,24-/m0/s1 MZPDPRITYJNRSG-ZEQRLZLVSA-N 50311985 3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol::CHEMBL1087650 Serine/threonine-protein kinase B-raf Homo sapiens 0.380000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311985&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46880136 104146346 CHEMBL1087650 ZINC49112081 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609120 CN1C[C@@H]2C[C@H]1CN2c1c(F)c(F)c(c(F)c1F)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C30H22F4N8/c1-40-13-17-11-16(40)14-41(17)29-26(33)24(31)23(25(32)27(29)34)21-7-10-36-30-22(18-3-2-4-20-19(18)12-37-38-20)28(39-42(21)30)15-5-8-35-9-6-15/h2-10,12,16-17H,11,13-14H2,1H3,(H,37,38)/t16-,17-/m0/s1 DIWBFIPASCHOPF-IRXDYDNUSA-N 50330923 3-(1H-indazol-4-yl)-2-(pyridin-4-yl)-7-(2,3,5,6-tetrafluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276181 Serine/threonine-protein kinase B-raf Homo sapiens 0.350000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330923&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836854 123110038 CHEMBL1276181 ZINC64448387 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609121 CN1C[C@@H]2C[C@H]1CN2c1ccc(c(F)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C30H25FN8/c1-37-16-21-13-20(37)17-38(21)19-5-6-23(25(31)14-19)27-9-12-33-30-28(22-3-2-4-26-24(22)15-34-35-26)29(36-39(27)30)18-7-10-32-11-8-18/h2-12,14-15,20-21H,13,16-17H2,1H3,(H,34,35)/t20-,21-/m0/s1 KESJHBITHJMSMQ-SFTDATJTSA-N 50330924 7-(2-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276169 Serine/threonine-protein kinase B-raf Homo sapiens 0.230000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330924&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836539 123110039 CHEMBL1276169 ZINC64436809 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609122 CN1C[C@@H]2C[C@H]1CN2c1cc(F)c(c(F)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C30H24F2N8/c1-38-15-20-11-19(38)16-39(20)18-12-23(31)28(24(32)13-18)26-7-10-34-30-27(21-3-2-4-25-22(21)14-35-36-25)29(37-40(26)30)17-5-8-33-9-6-17/h2-10,12-14,19-20H,11,15-16H2,1H3,(H,35,36)/t19-,20-/m0/s1 JCJSAFZMXVQVBR-PMACEKPBSA-N 50330905 7-(2,6-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276179 Serine/threonine-protein kinase B-raf Homo sapiens 0.160000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330905&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44187005 123110020 CHEMBL1276179 ZINC64453992 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609123 CN1C[C@@H]2C[C@H]1CN2c1cc(F)c(c(F)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(F)c2[nH]ncc12 InChI=1S/C30H23F3N8/c1-39-14-19-10-18(39)15-40(19)17-11-23(32)27(24(33)12-17)25-6-9-35-30-26(20-2-3-22(31)29-21(20)13-36-37-29)28(38-41(25)30)16-4-7-34-8-5-16/h2-9,11-13,18-19H,10,14-15H2,1H3,(H,36,37)/t18-,19-/m0/s1 IOXPBXUNYNTKQK-OALUTQOASA-N 50330925 7-(2,6-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-3-(7-fluoro-1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL1276186 Serine/threonine-protein kinase B-raf Homo sapiens 0.110000 ChEMBL 10.1021/jm1007566 10.7270/Q2HM58Q3 20961062 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330925&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49836966 123110040 CHEMBL1276186 ZINC64447732 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50628082 Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19) RJMUSRYZPJIFPJ-UHFFFAOYSA-N 11242 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide::med.21724, Compound 76::niclosamide Serine/threonine-protein kinase B-raf Homo sapiens >100000 ChEMBL 10.1021/ml100146z 10.7270/Q2XG9RDQ 24900231 Ren, X; Duan, L; He, Q; Zhang, Z; Zhou, Y; Wu, D; Pan, J; Pei, D; Ding, K; Ding, K. TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11242&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 4477 46511793 DB06803 ZINC03874496 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50609869 COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12 InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19) PRASIGARSOSUQT-UHFFFAOYSA-N 50331277 3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridine::CHEMBL1288582 Serine/threonine-protein kinase B-raf Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2010.09.119 10.7270/Q2JD4X29 20965724 Herdemann, M; Heit, I; Bosch, FU; Quintini, G; Scheipers, C; Weber, A Nycomed GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331277&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 49839480 123110392 CHEMBL1288582 ZINC64548888 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50643655 CNC(=O)c1ncc(C#Cc2cc(ccc2C)C(=O)Nc2ccc(CN3CCN(CCO)CC3)c(c2)C(F)(F)F)n1C InChI=1S/C30H33F3N6O3/c1-20-4-5-22(16-21(20)7-9-25-18-35-27(37(25)3)29(42)34-2)28(41)36-24-8-6-23(26(17-24)30(31,32)33)19-39-12-10-38(11-13-39)14-15-40/h4-6,8,16-18,40H,10-15,19H2,1-3H3,(H,34,42)(H,36,41) SUXYGJZMCWKJJI-UHFFFAOYSA-N 50345579 5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenylcarbamoyl)-2-methylphenyl)ethynyl)-N,1-dimethyl-1H-imidazole-2-carboxamide::CHEMBL1784637 Serine/threonine-protein kinase B-raf Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2011.04.060 10.7270/Q21G0MM8 21561767 Thomas, M; Huang, WS; Wen, D; Zhu, X; Wang, Y; Metcalf, CA; Liu, S; Chen, I; Romero, J; Zou, D; Sundaramoorthi, R; Li, F; Qi, J; Cai, L; Zhou, T; Commodore, L; Xu, Q; Keats, J; Wang, F; Wardwell, S; Ning, Y; Snodgrass, JT; Broudy, MI; Russian, K; Iuliucci, J; Rivera, VM; Sawyer, TK; Dalgarno, DC; Clackson, T; Shakespeare, WC ARIAD Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345579&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 46864270 131348510 CHEMBL1784637 ZINC71294545 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641407 Cn1cc(c(n1)-c1ccncc1)-c1ccc(cc1)-c1cc[nH]n1 InChI=1S/C18H15N5/c1-23-12-16(18(22-23)15-6-9-19-10-7-15)13-2-4-14(5-3-13)17-8-11-20-21-17/h2-12H,1H3,(H,20,21) ZZGACVWRPAHSSW-UHFFFAOYSA-N 25651 4-{1-methyl-4-[4-(1H-pyrazol-3-yl)phenyl]-1H-pyrazol-3-yl}pyridine::pyrazole based inhibitor, 33 Serine/threonine-protein kinase B-raf Homo sapiens 68 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25651&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25093324 56412941 ZINC40424253 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641408 Cc1c[nH]nc1-c1ccc(cc1)-c1cn(C)nc1-c1ccncc1 InChI=1S/C19H17N5/c1-13-11-21-22-18(13)15-5-3-14(4-6-15)17-12-24(2)23-19(17)16-7-9-20-10-8-16/h3-12H,1-2H3,(H,21,22) ITRATIKKSKBADF-UHFFFAOYSA-N 25652 4-{1-methyl-4-[4-(4-methyl-1H-pyrazol-3-yl)phenyl]-1H-pyrazol-3-yl}pyridine::pyrazole based inhibitor, 34 Serine/threonine-protein kinase B-raf Homo sapiens 7 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25652&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25093325 56412942 ZINC40974702 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641409 CCc1c[nH]nc1-c1ccc(cc1)-c1cn(C)nc1-c1ccncc1 InChI=1S/C20H19N5/c1-3-14-12-22-23-19(14)16-6-4-15(5-7-16)18-13-25(2)24-20(18)17-8-10-21-11-9-17/h4-13H,3H2,1-2H3,(H,22,23) OTSYWSKJDYYMGO-UHFFFAOYSA-N 50344452 4-(4-(4-(4-ethyl-1H-pyrazol-3-yl)phenyl)-1-methyl-1H-pyrazol-3-yl)pyridine::CHEMBL1780148 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344452&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54581683 131347388 CHEMBL1780148 ZINC71334183 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641410 Cn1cc(c(n1)-c1ccncc1)-c1ccc2-c3n[nH]cc3CCc2c1 InChI=1S/C20H17N5/c1-25-12-18(20(24-25)13-6-8-21-9-7-13)15-4-5-17-14(10-15)2-3-16-11-22-23-19(16)17/h4-12H,2-3H2,1H3,(H,22,23) VGYKWUYMCJJBJP-UHFFFAOYSA-N 50344453 7-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-4,5-dihydro-2H-benzo[g]indazole::CHEMBL1780149 Serine/threonine-protein kinase B-raf Homo sapiens 23 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344453&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54586536 131347389 CHEMBL1780149 ZINC71340406 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641411 Cn1cc(c(n1)-c1ccncc1)-c1ccc2-c3cn[nH]c3CCc2c1 InChI=1S/C20H17N5/c1-25-12-18(20(24-25)13-6-8-21-9-7-13)15-2-4-16-14(10-15)3-5-19-17(16)11-22-23-19/h2,4,6-12H,3,5H2,1H3,(H,22,23) QDIJXDZLGDCRMN-UHFFFAOYSA-N 50344454 7-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-4,5-dihydro-2H-benzo[e]indazole::CHEMBL1780150 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344454&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54587568 131347390 CHEMBL1780150 ZINC71332548 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641412 Cn1cc(c(n1)-c1ccncc1)-c1ccc2c(cc3[nH][nH]nc23)c1 InChI=1S/C18H14N6/c1-24-10-15(17(22-24)11-4-6-19-7-5-11)12-2-3-14-13(8-12)9-16-18(14)21-23-20-16/h2-10,20,23H,1H3 DBEGPDKBKPHRCX-UHFFFAOYSA-N 50344455 6-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,8-dihydroindeno[2,1-d][1,2,3]triazole::CHEMBL1780151 Serine/threonine-protein kinase B-raf Homo sapiens 11 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344455&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91932231 131347391 CHEMBL1780151 ZINC71411080 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641413 Cn1cc(c(n1)-c1ccncc1)-c1ccc(cc1)-c1c[nH]nn1 InChI=1S/C17H14N6/c1-23-11-15(17(21-23)14-6-8-18-9-7-14)12-2-4-13(5-3-12)16-10-19-22-20-16/h2-11H,1H3,(H,19,20,22) FMVRIEFJBLSHBW-UHFFFAOYSA-N 50344456 4-(4-(4-(2H-1,2,3-triazol-4-yl)phenyl)-1-methyl-1H-pyrazol-3-yl)pyridine::CHEMBL1780152 Serine/threonine-protein kinase B-raf Homo sapiens 55 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344456&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54587569 131347392 CHEMBL1780152 ZINC71341383 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641414 Cn1cc(c(n1)-c1ccncc1)-c1ccc(cc1)-c1cc[nH]c1 InChI=1S/C19H16N4/c1-23-13-18(19(22-23)16-6-9-20-10-7-16)15-4-2-14(3-5-15)17-8-11-21-12-17/h2-13,21H,1H3 YWOLNVDPDOQEOJ-UHFFFAOYSA-N 50344457 4-(4-(4-(1H-pyrrol-3-yl)phenyl)-1-methyl-1H-pyrazol-3-yl)pyridine::CHEMBL1780153 Serine/threonine-protein kinase B-raf Homo sapiens 788 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344457&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54586537 131347393 CHEMBL1780153 ZINC71332145 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641415 Cn1cc(c(n1)-c1ccncc1)-c1ccc2C(=O)NCc2c1 InChI=1S/C17H14N4O/c1-21-10-15(16(20-21)11-4-6-18-7-5-11)12-2-3-14-13(8-12)9-19-17(14)22/h2-8,10H,9H2,1H3,(H,19,22) FLQRRMNRUINMJD-UHFFFAOYSA-N 25654 5-[1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-isoindol-1-one::pyrazole based inhibitor, 36 Serine/threonine-protein kinase B-raf Homo sapiens 94 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25654&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25093327 56412944 ZINC62154059 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641416 CNC(=O)c1ccc(cc1)-c1cn(C)nc1-c1ccncc1 InChI=1S/C17H16N4O/c1-18-17(22)14-5-3-12(4-6-14)15-11-21(2)20-16(15)13-7-9-19-10-8-13/h3-11H,1-2H3,(H,18,22) XUMHNHGOUOTAFH-UHFFFAOYSA-N 50344458 CHEMBL1780155::N-methyl-4-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)benzamide Serine/threonine-protein kinase B-raf Homo sapiens 647 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344458&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54582674 131347394 CHEMBL1780155 ZINC71340289 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641417 Cn1cc(c(n1)-c1ccncc1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C15H14N4O2S/c1-19-10-14(15(18-19)12-6-8-17-9-7-12)11-2-4-13(5-3-11)22(16,20)21/h2-10H,1H3,(H2,16,20,21) NQOPVJZWYJSGOQ-UHFFFAOYSA-N 50344459 4-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)benzenesulfonamide::CHEMBL1780156 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344459&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 19355820 131347395 CHEMBL1780156 ZINC71333447 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641418 Cn1cc(c(n1)-c1ccncc1)-c1ccc2cn[nH]c2c1 InChI=1S/C16H13N5/c1-21-10-14(16(20-21)11-4-6-17-7-5-11)12-2-3-13-9-18-19-15(13)8-12/h2-10H,1H3,(H,18,19) RGCICAWWIIRITL-UHFFFAOYSA-N 25655 6-[1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-1H-indazole::pyrazole based inhibitor, 37 Serine/threonine-protein kinase B-raf Homo sapiens 139 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25655&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25093328 56412945 ZINC40424822 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641419 Cn1cc(c(n1)-c1ccncc1)-c1cccc2[nH]ncc12 InChI=1S/C16H13N5/c1-21-10-14(16(20-21)11-5-7-17-8-6-11)12-3-2-4-15-13(12)9-18-19-15/h2-10H,1H3,(H,18,19) AYUHNYSRYRXCAN-UHFFFAOYSA-N 50344460 4-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-1H-indazole::CHEMBL1780157 Serine/threonine-protein kinase B-raf Homo sapiens 468 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344460&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54583634 131347396 CHEMBL1780157 ZINC71340671 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641420 Cn1cc(c(n1)-c1ccncc1)-c1ccc2[nH]ncc2c1 InChI=1S/C16H13N5/c1-21-10-14(16(20-21)11-4-6-17-7-5-11)12-2-3-15-13(8-12)9-18-19-15/h2-10H,1H3,(H,18,19) XFPBOCXIBFTFEE-UHFFFAOYSA-N 50344461 5-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-1H-indazole::CHEMBL1780158 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344461&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54583635 131347397 CHEMBL1780158 ZINC71340263 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641421 Cn1cc(c(n1)-c1ccncc1)-c1ccc2[nH]ccc2c1 InChI=1S/C17H14N4/c1-21-11-15(17(20-21)12-4-7-18-8-5-12)13-2-3-16-14(10-13)6-9-19-16/h2-11,19H,1H3 UKDVQBRZBAYNAD-UHFFFAOYSA-N 50344462 5-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-1H-indole::CHEMBL1780159 Serine/threonine-protein kinase B-raf Homo sapiens 861 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344462&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54582675 131347398 CHEMBL1780159 ZINC71332049 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641422 Cn1cc(c(n1)-c1ccncc1)-c1ccc2cc[nH]c2c1 InChI=1S/C17H14N4/c1-21-11-15(17(20-21)13-4-7-18-8-5-13)14-3-2-12-6-9-19-16(12)10-14/h2-11,19H,1H3 KMDHVNISQCKKIU-UHFFFAOYSA-N 50344463 6-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-1H-indole::CHEMBL1780160 Serine/threonine-protein kinase B-raf Homo sapiens 328 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344463&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54587570 131347399 CHEMBL1780160 ZINC71340385 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641423 Cn1cc(c(n1)-c1ccncc1)-c1ccc2c(O)cccc2c1 InChI=1S/C19H15N3O/c1-22-12-17(19(21-22)13-7-9-20-10-8-13)15-5-6-16-14(11-15)3-2-4-18(16)23/h2-12,23H,1H3 HXGBUKKPDSRQTR-UHFFFAOYSA-N 50344464 6-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)naphthalen-1-ol::CHEMBL1780161 Serine/threonine-protein kinase B-raf Homo sapiens 1.4 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344464&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11601866 131347400 CHEMBL1780161 ZINC35905663 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641424 Cn1cc(c(n1)-c1ccncc1)-c1ccc2cc(O)ccc2c1 InChI=1S/C19H15N3O/c1-22-12-18(19(21-22)13-6-8-20-9-7-13)16-3-2-15-11-17(23)5-4-14(15)10-16/h2-12,23H,1H3 UFYYHTRPMRGEQA-UHFFFAOYSA-N 50344465 6-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)naphthalen-2-ol::CHEMBL1780162 Serine/threonine-protein kinase B-raf Homo sapiens 77 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344465&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11659444 131347401 CHEMBL1780162 ZINC38207484 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641425 Cn1cc(N)c(n1)-c1ccncc1 InChI=1S/C9H10N4/c1-13-6-8(10)9(12-13)7-2-4-11-5-3-7/h2-6H,10H2,1H3 PDPGHKNJMFNIHE-UHFFFAOYSA-N 50344466 1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-amine::CHEMBL1780163 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344466&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54581685 131347402 CHEMBL1780163 ZINC71340244 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641426 Cn1cc(O)c(n1)-c1ccncc1 InChI=1S/C9H9N3O/c1-12-6-8(13)9(11-12)7-2-4-10-5-3-7/h2-6,13H,1H3 ODYJPJVQXWRZBC-UHFFFAOYSA-N 50344467 1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-ol::CHEMBL1780164 Serine/threonine-protein kinase B-raf Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344467&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54584611 131347403 CHEMBL1780164 ZINC71340644 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641427 C1c2c[nH]nc2-c2ccc(cc12)-c1cn(nc1-c1ccncc1)C1CCNCC1 InChI=1S/C23H22N6/c1-2-20-17(12-18-13-26-27-22(18)20)11-16(1)21-14-29(19-5-9-25-10-6-19)28-23(21)15-3-7-24-8-4-15/h1-4,7-8,11,13-14,19,25H,5-6,9-10,12H2,(H,26,27) OAHNTYYIALLVPB-UHFFFAOYSA-N 50344468 6-(1-(piperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780165 Serine/threonine-protein kinase B-raf Homo sapiens 3 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344468&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11516491 131347404 CHEMBL1780165 ZINC71340836 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641428 CN1CCC(CC1)n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C24H24N6/c1-29-10-6-20(7-11-29)30-15-22(24(28-30)16-4-8-25-9-5-16)17-2-3-21-18(12-17)13-19-14-26-27-23(19)21/h2-5,8-9,12,14-15,20H,6-7,10-11,13H2,1H3,(H,26,27) BXUHJRIRASLBOI-UHFFFAOYSA-N 50344469 6-(1-(1-methylpiperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780166 Serine/threonine-protein kinase B-raf Homo sapiens 8 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344469&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54583636 131347405 CHEMBL1780166 ZINC71332543 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641429 C1CC2CC(CC1N2)n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C25H24N6/c1-4-22-17(10-18-13-27-29-24(18)22)9-16(1)23-14-31(21-11-19-2-3-20(12-21)28-19)30-25(23)15-5-7-26-8-6-15/h1,4-9,13-14,19-21,28H,2-3,10-12H2,(H,27,29) IUXJVYUKPTXHGQ-UHFFFAOYSA-N 50344470 6-(1-(8-azabicyclo[3.2.1]octan-3-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780167 Serine/threonine-protein kinase B-raf Homo sapiens 0.57 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344470&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54583637 131347406 CHEMBL1780167 ZINC71340655 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641430 C1c2c[nH]nc2-c2ccc(cc12)-c1cn(nc1-c1ccncc1)C1CCCNC1 InChI=1S/C23H22N6/c1-2-19(13-25-7-1)29-14-21(23(28-29)15-5-8-24-9-6-15)16-3-4-20-17(10-16)11-18-12-26-27-22(18)20/h3-6,8-10,12,14,19,25H,1-2,7,11,13H2,(H,26,27) CVSUPQHIXALXEL-UHFFFAOYSA-N 50344471 6-(1-(piperidin-3-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780168 Serine/threonine-protein kinase B-raf Homo sapiens 3.7 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344471&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54586538 131347407 CHEMBL1780168 ZINC71335081 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641431 C1c2c[nH]nc2-c2ccc(cc12)-c1cn(nc1-c1ccncc1)C1CCCNCC1 InChI=1S/C24H24N6/c1-2-20(7-11-25-8-1)30-15-22(24(29-30)16-5-9-26-10-6-16)17-3-4-21-18(12-17)13-19-14-27-28-23(19)21/h3-6,9-10,12,14-15,20,25H,1-2,7-8,11,13H2,(H,27,28) OQMXCWUUGNUFSO-UHFFFAOYSA-N 50344472 6-(1-(azepan-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780169 Serine/threonine-protein kinase B-raf Homo sapiens 3.2 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344472&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54585557 131347408 CHEMBL1780169 ZINC71333698 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641432 N[C@H]1CC[C@@H](CC1)n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C24H24N6/c25-19-2-4-20(5-3-19)30-14-22(24(29-30)15-7-9-26-10-8-15)16-1-6-21-17(11-16)12-18-13-27-28-23(18)21/h1,6-11,13-14,19-20H,2-5,12,25H2,(H,27,28)/t19-,20- IITDRWYWCOFDCY-MXVIHJGJSA-N 50344473 CHEMBL1780170::trans-4-(4-(2,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)cyclohexanamine Serine/threonine-protein kinase B-raf Homo sapiens 0.66 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344473&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54582676 131347409 CHEMBL1780170 ZINC71331949 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641433 N[C@H]1CC[C@H](CC1)n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C24H24N6/c25-19-2-4-20(5-3-19)30-14-22(24(29-30)15-7-9-26-10-8-15)16-1-6-21-17(11-16)12-18-13-27-28-23(18)21/h1,6-11,13-14,19-20H,2-5,12,25H2,(H,27,28)/t19-,20+ IITDRWYWCOFDCY-BGYRXZFFSA-N 50344474 CHEMBL1780171::cis-4-(4-(2,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)cyclohexanamine Serine/threonine-protein kinase B-raf Homo sapiens 22.9 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344474&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54582676 131347410 CHEMBL1780171 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641434 CNCCn1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C21H20N6/c1-22-8-9-27-13-19(21(26-27)14-4-6-23-7-5-14)15-2-3-18-16(10-15)11-17-12-24-25-20(17)18/h2-7,10,12-13,22H,8-9,11H2,1H3,(H,24,25) KGIWTSNDMWSYJW-UHFFFAOYSA-N 50344475 2-(4-(2,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)-N-methylethanamine::CHEMBL1780172 Serine/threonine-protein kinase B-raf Homo sapiens 72.5 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344475&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54585558 131347411 CHEMBL1780172 ZINC71331341 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641435 O[C@@H]1CCC[C@@H](C1)n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C24H23N5O/c30-20-3-1-2-19(12-20)29-14-22(24(28-29)15-6-8-25-9-7-15)16-4-5-21-17(10-16)11-18-13-26-27-23(18)21/h4-10,13-14,19-20,30H,1-3,11-12H2,(H,26,27)/t19-,20+/m0/s1 VKTWVYJAUHKWAJ-VQTJNVASSA-N 50344476 CHEMBL1780173::cis-(1R,3S)-3-(4-(2,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)cyclohexanol Serine/threonine-protein kinase B-raf Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344476&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54586539 131347412 CHEMBL1780173 ZINC71331206 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641436 C1c2c[nH]nc2-c2ccc(cc12)-c1cn(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C24H17N5/c1-2-4-20(5-3-1)29-15-22(24(28-29)16-8-10-25-11-9-16)17-6-7-21-18(12-17)13-19-14-26-27-23(19)21/h1-12,14-15H,13H2,(H,26,27) WQOHCLXKZOFZAI-UHFFFAOYSA-N 50344477 6-(1-phenyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780174 Serine/threonine-protein kinase B-raf Homo sapiens 4.6 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344477&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54585559 131347413 CHEMBL1780174 ZINC71334223 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641437 O[C@@H]1CNCC[C@H]1n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C23H22N6O/c30-21-12-25-8-5-20(21)29-13-19(23(28-29)14-3-6-24-7-4-14)15-1-2-18-16(9-15)10-17-11-26-27-22(17)18/h1-4,6-7,9,11,13,20-21,25,30H,5,8,10,12H2,(H,26,27)/t20-,21-/m1/s1 RLQVFZWNEHNDCB-NHCUHLMSSA-N 50344478 (3R,4R)-4-(4-(2,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)piperidin-3-ol::CHEMBL1780175 Serine/threonine-protein kinase B-raf Homo sapiens 4.9 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344478&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54586540 131347414 CHEMBL1780175 ZINC71340617 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641438 C1c2c[nH]nc2-c2ccc(cc12)-c1cn(nc1-c1ccncc1)C1CC2COCC(C1)N2 InChI=1S/C25H24N6O/c1-2-22-17(8-18-11-27-29-24(18)22)7-16(1)23-12-31(30-25(23)15-3-5-26-6-4-15)21-9-19-13-32-14-20(10-21)28-19/h1-7,11-12,19-21,28H,8-10,13-14H2,(H,27,29) YEEFQERYHQOGGF-UHFFFAOYSA-N 50344479 7-(4-(2,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)-3-oxa-9-azabicyclo[3.3.1]nonane::CHEMBL1780176 Serine/threonine-protein kinase B-raf Homo sapiens 5 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344479&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54586541 131347415 CHEMBL1780176 ZINC71341070 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641439 F[C@@H]1CNCC[C@H]1n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C23H21FN6/c24-20-12-26-8-5-21(20)30-13-19(23(29-30)14-3-6-25-7-4-14)15-1-2-18-16(9-15)10-17-11-27-28-22(17)18/h1-4,6-7,9,11,13,20-21,26H,5,8,10,12H2,(H,27,28)/t20-,21-/m1/s1 XMUIHQBLEQJXIH-NHCUHLMSSA-N 50344480 6-(1-((3R,4R)-3-fluoropiperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780177 Serine/threonine-protein kinase B-raf Homo sapiens 1.4 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344480&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53302367 131347416 CHEMBL1780177 ZINC71331425 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641440 F[C@H]1CNCC[C@H]1n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C23H21FN6/c24-20-12-26-8-5-21(20)30-13-19(23(29-30)14-3-6-25-7-4-14)15-1-2-18-16(9-15)10-17-11-27-28-22(17)18/h1-4,6-7,9,11,13,20-21,26H,5,8,10,12H2,(H,27,28)/t20-,21+/m0/s1 XMUIHQBLEQJXIH-LEWJYISDSA-N 50344481 6-(1-((3S,4R)-3-fluoropiperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780178 Serine/threonine-protein kinase B-raf Homo sapiens 3.8 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344481&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54584612 131347417 CHEMBL1780178 ZINC71332018 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641441 F[C@H]1CCNC[C@H]1n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C23H21FN6/c24-20-5-8-26-12-21(20)30-13-19(23(29-30)14-3-6-25-7-4-14)15-1-2-18-16(9-15)10-17-11-27-28-22(17)18/h1-4,6-7,9,11,13,20-21,26H,5,8,10,12H2,(H,27,28)/t20-,21+/m0/s1 KJKYPFOPJLZNBB-LEWJYISDSA-N 50344482 6-(1-((3R,4S)-4-fluoropiperidin-3-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780179 Serine/threonine-protein kinase B-raf Homo sapiens 3.2 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344482&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54584613 131347418 CHEMBL1780179 ZINC71334920 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641442 F[C@@H]1CNCC[C@H]1n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C23H21FN6/c24-20-12-26-8-5-21(20)30-13-19(23(29-30)14-3-6-25-7-4-14)15-1-2-18-16(9-15)10-17-11-27-28-22(17)18/h1-4,6-7,9,11,13,20-21,26H,5,8,10,12H2,(H,27,28)/t20-,21-/m1/s1 XMUIHQBLEQJXIH-NHCUHLMSSA-N 50344480 6-(1-((3R,4R)-3-fluoropiperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780177 Serine/threonine-protein kinase B-raf Homo sapiens 1.40 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344480&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53302367 131347416 CHEMBL1780177 ZINC71331425 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641443 F[C@H]1CNCC[C@@H]1n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C23H21FN6/c24-20-12-26-8-5-21(20)30-13-19(23(29-30)14-3-6-25-7-4-14)15-1-2-18-16(9-15)10-17-11-27-28-22(17)18/h1-4,6-7,9,11,13,20-21,26H,5,8,10,12H2,(H,27,28)/t20-,21-/m0/s1 XMUIHQBLEQJXIH-SFTDATJTSA-N 50344483 6-(1-((3S,4S)-3-fluoropiperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780180 Serine/threonine-protein kinase B-raf Homo sapiens 1.25 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54585560 131347419 CHEMBL1780180 ZINC71341225 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641444 C1c2c[nH]nc2-c2ccc(cc12)-c1cn(nc1-c1ccncc1)C1CCNCC1 InChI=1S/C23H22N6/c1-2-20-17(12-18-13-26-27-22(18)20)11-16(1)21-14-29(19-5-9-25-10-6-19)28-23(21)15-3-7-24-8-4-15/h1-4,7-8,11,13-14,19,25H,5-6,9-10,12H2,(H,26,27) OAHNTYYIALLVPB-UHFFFAOYSA-N 50344468 6-(1-(piperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780165 Serine/threonine-protein kinase B-raf Homo sapiens 230 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344468&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11516491 131347404 CHEMBL1780165 ZINC71340836 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641445 CN1CCC(CC1)n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C24H24N6/c1-29-10-6-20(7-11-29)30-15-22(24(28-30)16-4-8-25-9-5-16)17-2-3-21-18(12-17)13-19-14-26-27-23(19)21/h2-5,8-9,12,14-15,20H,6-7,10-11,13H2,1H3,(H,26,27) BXUHJRIRASLBOI-UHFFFAOYSA-N 50344469 6-(1-(1-methylpiperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780166 Serine/threonine-protein kinase B-raf Homo sapiens 886 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344469&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54583636 131347405 CHEMBL1780166 ZINC71332543 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641446 C1CC2CC(CC1N2)n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C25H24N6/c1-4-22-17(10-18-13-27-29-24(18)22)9-16(1)23-14-31(21-11-19-2-3-20(12-21)28-19)30-25(23)15-5-7-26-8-6-15/h1,4-9,13-14,19-21,28H,2-3,10-12H2,(H,27,29) IUXJVYUKPTXHGQ-UHFFFAOYSA-N 50344470 6-(1-(8-azabicyclo[3.2.1]octan-3-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780167 Serine/threonine-protein kinase B-raf Homo sapiens 262 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344470&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54583637 131347406 CHEMBL1780167 ZINC71340655 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641447 C1c2c[nH]nc2-c2ccc(cc12)-c1cn(nc1-c1ccncc1)C1CCCNC1 InChI=1S/C23H22N6/c1-2-19(13-25-7-1)29-14-21(23(28-29)15-5-8-24-9-6-15)16-3-4-20-17(10-16)11-18-12-26-27-22(18)20/h3-6,8-10,12,14,19,25H,1-2,7,11,13H2,(H,26,27) CVSUPQHIXALXEL-UHFFFAOYSA-N 50344471 6-(1-(piperidin-3-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780168 Serine/threonine-protein kinase B-raf Homo sapiens 1671 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344471&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54586538 131347407 CHEMBL1780168 ZINC71335081 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641448 C1c2c[nH]nc2-c2ccc(cc12)-c1cn(nc1-c1ccncc1)C1CCCNCC1 InChI=1S/C24H24N6/c1-2-20(7-11-25-8-1)30-15-22(24(29-30)16-5-9-26-10-6-16)17-3-4-21-18(12-17)13-19-14-27-28-23(19)21/h3-6,9-10,12,14-15,20,25H,1-2,7-8,11,13H2,(H,27,28) OQMXCWUUGNUFSO-UHFFFAOYSA-N 50344472 6-(1-(azepan-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780169 Serine/threonine-protein kinase B-raf Homo sapiens 1540 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344472&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54585557 131347408 CHEMBL1780169 ZINC71333698 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641449 N[C@H]1CC[C@@H](CC1)n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C24H24N6/c25-19-2-4-20(5-3-19)30-14-22(24(29-30)15-7-9-26-10-8-15)16-1-6-21-17(11-16)12-18-13-27-28-23(18)21/h1,6-11,13-14,19-20H,2-5,12,25H2,(H,27,28)/t19-,20- IITDRWYWCOFDCY-MXVIHJGJSA-N 50344473 CHEMBL1780170::trans-4-(4-(2,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)cyclohexanamine Serine/threonine-protein kinase B-raf Homo sapiens 396 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344473&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54582676 131347409 CHEMBL1780170 ZINC71331949 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641450 N[C@H]1CC[C@H](CC1)n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C24H24N6/c25-19-2-4-20(5-3-19)30-14-22(24(29-30)15-7-9-26-10-8-15)16-1-6-21-17(11-16)12-18-13-27-28-23(18)21/h1,6-11,13-14,19-20H,2-5,12,25H2,(H,27,28)/t19-,20+ IITDRWYWCOFDCY-BGYRXZFFSA-N 50344474 CHEMBL1780171::cis-4-(4-(2,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)cyclohexanamine Serine/threonine-protein kinase B-raf Homo sapiens 1516 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344474&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54582676 131347410 CHEMBL1780171 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641451 CNCCn1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C21H20N6/c1-22-8-9-27-13-19(21(26-27)14-4-6-23-7-5-14)15-2-3-18-16(10-15)11-17-12-24-25-20(17)18/h2-7,10,12-13,22H,8-9,11H2,1H3,(H,24,25) KGIWTSNDMWSYJW-UHFFFAOYSA-N 50344475 2-(4-(2,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)-N-methylethanamine::CHEMBL1780172 Serine/threonine-protein kinase B-raf Homo sapiens 8164 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344475&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54585558 131347411 CHEMBL1780172 ZINC71331341 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641452 O[C@@H]1CCC[C@@H](C1)n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C24H23N5O/c30-20-3-1-2-19(12-20)29-14-22(24(28-29)15-6-8-25-9-7-15)16-4-5-21-17(10-16)11-18-13-26-27-23(18)21/h4-10,13-14,19-20,30H,1-3,11-12H2,(H,26,27)/t19-,20+/m0/s1 VKTWVYJAUHKWAJ-VQTJNVASSA-N 50344476 CHEMBL1780173::cis-(1R,3S)-3-(4-(2,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)cyclohexanol Serine/threonine-protein kinase B-raf Homo sapiens 607 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344476&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54586539 131347412 CHEMBL1780173 ZINC71331206 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641453 C1c2c[nH]nc2-c2ccc(cc12)-c1cn(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C24H17N5/c1-2-4-20(5-3-1)29-15-22(24(28-29)16-8-10-25-11-9-16)17-6-7-21-18(12-17)13-19-14-26-27-23(19)21/h1-12,14-15H,13H2,(H,26,27) WQOHCLXKZOFZAI-UHFFFAOYSA-N 50344477 6-(1-phenyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780174 Serine/threonine-protein kinase B-raf Homo sapiens 4372 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344477&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54585559 131347413 CHEMBL1780174 ZINC71334223 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641454 O[C@@H]1CNCC[C@H]1n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C23H22N6O/c30-21-12-25-8-5-20(21)29-13-19(23(28-29)14-3-6-24-7-4-14)15-1-2-18-16(9-15)10-17-11-26-27-22(17)18/h1-4,6-7,9,11,13,20-21,25,30H,5,8,10,12H2,(H,26,27)/t20-,21-/m1/s1 RLQVFZWNEHNDCB-NHCUHLMSSA-N 50344478 (3R,4R)-4-(4-(2,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)piperidin-3-ol::CHEMBL1780175 Serine/threonine-protein kinase B-raf Homo sapiens 4871 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344478&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54586540 131347414 CHEMBL1780175 ZINC71340617 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641455 C1c2c[nH]nc2-c2ccc(cc12)-c1cn(nc1-c1ccncc1)C1CC2COCC(C1)N2 InChI=1S/C25H24N6O/c1-2-22-17(8-18-11-27-29-24(18)22)7-16(1)23-12-31(30-25(23)15-3-5-26-6-4-15)21-9-19-13-32-14-20(10-21)28-19/h1-7,11-12,19-21,28H,8-10,13-14H2,(H,27,29) YEEFQERYHQOGGF-UHFFFAOYSA-N 50344479 7-(4-(2,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)-3-oxa-9-azabicyclo[3.3.1]nonane::CHEMBL1780176 Serine/threonine-protein kinase B-raf Homo sapiens 619 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344479&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54586541 131347415 CHEMBL1780176 ZINC71341070 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641456 F[C@@H]1CNCC[C@H]1n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C23H21FN6/c24-20-12-26-8-5-21(20)30-13-19(23(29-30)14-3-6-25-7-4-14)15-1-2-18-16(9-15)10-17-11-27-28-22(17)18/h1-4,6-7,9,11,13,20-21,26H,5,8,10,12H2,(H,27,28)/t20-,21-/m1/s1 XMUIHQBLEQJXIH-NHCUHLMSSA-N 50344480 6-(1-((3R,4R)-3-fluoropiperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780177 Serine/threonine-protein kinase B-raf Homo sapiens 700 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344480&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53302367 131347416 CHEMBL1780177 ZINC71331425 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641457 F[C@H]1CNCC[C@H]1n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C23H21FN6/c24-20-12-26-8-5-21(20)30-13-19(23(29-30)14-3-6-25-7-4-14)15-1-2-18-16(9-15)10-17-11-27-28-22(17)18/h1-4,6-7,9,11,13,20-21,26H,5,8,10,12H2,(H,27,28)/t20-,21+/m0/s1 XMUIHQBLEQJXIH-LEWJYISDSA-N 50344481 6-(1-((3S,4R)-3-fluoropiperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780178 Serine/threonine-protein kinase B-raf Homo sapiens 407 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344481&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54584612 131347417 CHEMBL1780178 ZINC71332018 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641458 F[C@H]1CCNC[C@H]1n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C23H21FN6/c24-20-5-8-26-12-21(20)30-13-19(23(29-30)14-3-6-25-7-4-14)15-1-2-18-16(9-15)10-17-11-27-28-22(17)18/h1-4,6-7,9,11,13,20-21,26H,5,8,10,12H2,(H,27,28)/t20-,21+/m0/s1 KJKYPFOPJLZNBB-LEWJYISDSA-N 50344482 6-(1-((3R,4S)-4-fluoropiperidin-3-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780179 Serine/threonine-protein kinase B-raf Homo sapiens 2119 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344482&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54584613 131347418 CHEMBL1780179 ZINC71334920 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641459 F[C@@H]1CNCC[C@H]1n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C23H21FN6/c24-20-12-26-8-5-21(20)30-13-19(23(29-30)14-3-6-25-7-4-14)15-1-2-18-16(9-15)10-17-11-27-28-22(17)18/h1-4,6-7,9,11,13,20-21,26H,5,8,10,12H2,(H,27,28)/t20-,21-/m1/s1 XMUIHQBLEQJXIH-NHCUHLMSSA-N 50344480 6-(1-((3R,4R)-3-fluoropiperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780177 Serine/threonine-protein kinase B-raf Homo sapiens 700 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344480&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53302367 131347416 CHEMBL1780177 ZINC71331425 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50641460 F[C@H]1CNCC[C@@H]1n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 InChI=1S/C23H21FN6/c24-20-12-26-8-5-21(20)30-13-19(23(29-30)14-3-6-25-7-4-14)15-1-2-18-16(9-15)10-17-11-27-28-22(17)18/h1-4,6-7,9,11,13,20-21,26H,5,8,10,12H2,(H,27,28)/t20-,21-/m0/s1 XMUIHQBLEQJXIH-SFTDATJTSA-N 50344483 6-(1-((3S,4S)-3-fluoropiperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole::CHEMBL1780180 Serine/threonine-protein kinase B-raf Homo sapiens 672 ChEMBL 10.1016/j.bmcl.2010.12.038 10.7270/Q20R9PQ9 21536432 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Array BioPharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54585560 131347419 CHEMBL1780180 ZINC71341225 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50640330 Oc1ccccc1C1CC(=NN1C(=O)c1ccc(s1)-c1ccccn1)c1cccnc1 InChI=1S/C24H18N4O2S/c29-21-9-2-1-7-17(21)20-14-19(16-6-5-12-25-15-16)27-28(20)24(30)23-11-10-22(31-23)18-8-3-4-13-26-18/h1-13,15,20,29H,14H2 QPGIWMWTJYDFOF-UHFFFAOYSA-N 50343948 (5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(pyridin-2-yl)thiophen-2-yl)methanone::CHEMBL1778666::rac-(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(pyridin-2-yl)thiophen-2-yl)methanone Serine/threonine-protein kinase B-raf Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2010.06.113 10.7270/Q2MP53M9 20634068 Duffey, MO; Adams, R; Blackburn, C; Chau, RW; Chen, S; Galvin, KM; Garcia, K; Gould, AE; Greenspan, PD; Harrison, S; Huang, SC; Kim, MS; Kulkarni, B; Langston, S; Liu, JX; Ma, LT; Menon, S; Nagayoshi, M; Rowland, RS; Vos, TJ; Xu, T; Yang, JJ; Yu, S; Zhang, Q Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343948&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24963588 131346884 CHEMBL1778666 ZINC71340635 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50629212 CN(C)Cc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H29F3N4O3/c1-36(2)16-17-11-20(13-21(12-17)29(30,31)32)28(38)34-22-5-3-18-4-6-23(15-19(18)14-22)39-25-9-10-33-27-24(25)7-8-26(37)35-27/h4,6,9-13,15,22H,3,5,7-8,14,16H2,1-2H3,(H,34,38)(H,33,35,37)/t22-/m1/s1 DZUFTTMDQLYMBE-JOCHJYFZSA-N 50339609 3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide::CHEMBL1688860 Serine/threonine-protein kinase B-raf Homo sapiens 4.7 ChEMBL 10.1021/jm101479y 10.7270/Q2DB824F 21341678 Gould, AE; Adams, R; Adhikari, S; Aertgeerts, K; Afroze, R; Blackburn, C; Calderwood, EF; Chau, R; Chouitar, J; Duffey, MO; England, DB; Farrer, C; Forsyth, N; Garcia, K; Gaulin, J; Greenspan, PD; Guo, R; Harrison, SJ; Huang, SC; Iartchouk, N; Janowick, D; Kim, MS; Kulkarni, B; Langston, SP; Liu, JX; Ma, LT; Menon, S; Mizutani, H; Paske, E; Renou, CC; Rezaei, M; Rowland, RS; Sintchak, MD; Smith, MD; Stroud, SG; Tregay, M; Tian, Y; Veiby, OP; Vos, TJ; Vyskocil, S; Williams, J; Xu, T; Yang, JJ; Yano, J; Zeng, H; Zhang, DM; Zhang, Q; Galvin, KM Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339609&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 50990961 125089711 CHEMBL1688860 ZINC66128693 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50629213 CC(C)(N)c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 InChI=1S/C29H29F3N4O3/c1-28(2,33)19-11-18(12-20(15-19)29(30,31)32)27(38)35-21-5-3-16-4-6-22(14-17(16)13-21)39-24-9-10-34-26-23(24)7-8-25(37)36-26/h4,6,9-12,14-15,21H,3,5,7-8,13,33H2,1-2H3,(H,35,38)(H,34,36,37)/t21-/m1/s1 GXEGTVQATHKFDH-OAQYLSRUSA-N 50339608 3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide::CHEMBL1688861 Serine/threonine-protein kinase B-raf Homo sapiens 4.2 ChEMBL 10.1021/jm101479y 10.7270/Q2DB824F 21341678 Gould, AE; Adams, R; Adhikari, S; Aertgeerts, K; Afroze, R; Blackburn, C; Calderwood, EF; Chau, R; Chouitar, J; Duffey, MO; England, DB; Farrer, C; Forsyth, N; Garcia, K; Gaulin, J; Greenspan, PD; Guo, R; Harrison, SJ; Huang, SC; Iartchouk, N; Janowick, D; Kim, MS; Kulkarni, B; Langston, SP; Liu, JX; Ma, LT; Menon, S; Mizutani, H; Paske, E; Renou, CC; Rezaei, M; Rowland, RS; Sintchak, MD; Smith, MD; Stroud, SG; Tregay, M; Tian, Y; Veiby, OP; Vos, TJ; Vyskocil, S; Williams, J; Xu, T; Yang, JJ; Yano, J; Zeng, H; Zhang, DM; Zhang, Q; Galvin, KM Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339608&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 50992247 125089710 CHEMBL1688861 ZINC66128696 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50664116 CCOC(=O)c1cccc(Nc2nc(N)nc3nc[nH]c23)c1 InChI=1S/C14H14N6O2/c1-2-22-13(21)8-4-3-5-9(6-8)18-12-10-11(17-7-16-10)19-14(15)20-12/h3-7H,2H2,1H3,(H4,15,16,17,18,19,20) YKLYVNLMRJKAPY-UHFFFAOYSA-N 50354685 CHEMBL1834039 Serine/threonine-protein kinase B-raf Homo sapiens 7E2 ChEMBL 10.1016/j.bmcl.2011.08.010 10.7270/Q2RJ4JWR 21873050 Park, H; Choi, H; Hong, S; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50354685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50354685&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16420340 136361371 CHEMBL1834039 ZINC09422426 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50664117 NC(=O)c1ccc(Nc2nnc(-c3ccc(O)cc3)c3ccccc23)cc1 InChI=1S/C21H16N4O2/c22-20(27)14-5-9-15(10-6-14)23-21-18-4-2-1-3-17(18)19(24-25-21)13-7-11-16(26)12-8-13/h1-12,26H,(H2,22,27)(H,23,25) LGCIFOOQZRHNIN-UHFFFAOYSA-N 50354686 CHEMBL1524400 Serine/threonine-protein kinase B-raf Homo sapiens 2.1E3 ChEMBL 10.1016/j.bmcl.2011.08.010 10.7270/Q2RJ4JWR 21873050 Park, H; Choi, H; Hong, S; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50354686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50354686&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 5438291 136361372 CHEMBL1524400 ZINC17123471 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50664118 Nc1ccccc1Oc1ccc(cc1)-c1nc(N)nc(N)n1 InChI=1S/C15H14N6O/c16-11-3-1-2-4-12(11)22-10-7-5-9(6-8-10)13-19-14(17)21-15(18)20-13/h1-8H,16H2,(H4,17,18,19,20,21) MRYYFGCEGIUXMF-UHFFFAOYSA-N 50354687 CHEMBL1834040 Serine/threonine-protein kinase B-raf Homo sapiens 1.18E4 ChEMBL 10.1016/j.bmcl.2011.08.010 10.7270/Q2RJ4JWR 21873050 Park, H; Choi, H; Hong, S; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50354687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50354687&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 745571 136361373 CHEMBL1834040 ZINC00187843 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50664119 Cc1ccc(\C=C\c2nc(N)nc(n2)-c2ccccc2O)o1 InChI=1S/C16H14N4O2/c1-10-6-7-11(22-10)8-9-14-18-15(20-16(17)19-14)12-4-2-3-5-13(12)21/h2-9,21H,1H3,(H2,17,18,19,20)/b9-8+ LRNHALJEVHZMBB-CMDGGOBGSA-N 50354688 CHEMBL1834041 Serine/threonine-protein kinase B-raf Homo sapiens 2E4 ChEMBL 10.1016/j.bmcl.2011.08.010 10.7270/Q2RJ4JWR 21873050 Park, H; Choi, H; Hong, S; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50354688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50354688&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 17339159 136361374 CHEMBL1834041 ZINC04281861 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50664120 Oc1ccc(cc1)\N=C1/NC(=O)\C(S1)=C\c1c[nH]c2ccccc12 InChI=1S/C18H13N3O2S/c22-13-7-5-12(6-8-13)20-18-21-17(23)16(24-18)9-11-10-19-15-4-2-1-3-14(11)15/h1-10,19,22H,(H,20,21,23)/b16-9- FDROHGNBKPFIAH-SXGWCWSVSA-N 50354689 CHEMBL1834042 Serine/threonine-protein kinase B-raf Homo sapiens 1.85E4 ChEMBL 10.1016/j.bmcl.2011.08.010 10.7270/Q2RJ4JWR 21873050 Park, H; Choi, H; Hong, S; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50354689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50354689&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 5424052 136361375 CHEMBL1834042 ZINC06931990 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50664121 Cc1ccc(CNC(=O)c2c(N)n(-c3cccc(O)c3)c3nc4ccccc4nc23)cc1 InChI=1S/C25H21N5O2/c1-15-9-11-16(12-10-15)14-27-25(32)21-22-24(29-20-8-3-2-7-19(20)28-22)30(23(21)26)17-5-4-6-18(31)13-17/h2-13,31H,14,26H2,1H3,(H,27,32) ZEFANEBOMGSMNZ-UHFFFAOYSA-N 50354690 CHEMBL1834043 Serine/threonine-protein kinase B-raf Homo sapiens 1.26E4 ChEMBL 10.1016/j.bmcl.2011.08.010 10.7270/Q2RJ4JWR 21873050 Park, H; Choi, H; Hong, S; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50354690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50354690&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 1402819 136361376 CHEMBL1834043 ZINC06028405 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50667081 Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(Cc4ccccn4)CC3)c3ccccc23)c2ccccc12 InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39) AXRCEOKUDYDWLF-UHFFFAOYSA-N 50128285 3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indol-3-yl]-pyrrole-2,5-dione::CHEMBL300138 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50128285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50128285&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 176167 104020050 CHEMBL300138 5693 ZINC01494900 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50668366 COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30) NHHQJBCNYHBUSI-UHFFFAOYSA-N 60665 BDBM50249542::US9145414, R406::US9212178, R406 Serine/threonine-protein kinase B-raf Homo sapiens 380 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60665&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 585 3PIY,3FQS 11213558 316921779 DB07159 ZINC13555629 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50668528 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50665928 CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12 InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34) HZTYDQRUAWIZRE-UHFFFAOYSA-N 27817 2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-dihydro-1H-indol-6-yl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluoro-N-methylbenzamide::pyrrolo[2,3-d]pyrimidine deriv., 40 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27817&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25182616 57560329 5683 ZINC43202844 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50667376 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nc(cs3)-c3cccnc3)c2)CC1 InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32) WJEOLQLKVOPQFV-UHFFFAOYSA-N 50355495 CHEMBL1908391 Serine/threonine-protein kinase B-raf Homo sapiens 1800 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355495&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search G65 7TVX,5MQL,7JU7 10074640 136959519 63450 CHEMBL1908391 ZINC34177219 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50667694 Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1 InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1 BPNUQXPIQBZCMR-IBGZPJMESA-N 15138 5-indazolyl pyridine 11g::5-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-3-methyl-1H-indazole::A-674563::Biochemistry 469551 Compound 11::indazole-pyridine, 7 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15138&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search SS3 2UZT 11314340 46515449 DB08568 5655 ZINC16052569 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50688278 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50691149 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Serine/threonine-protein kinase B-raf Homo sapiens 130 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50675388 CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc12 InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19) MFAQYJIYDMLAIM-UHFFFAOYSA-N 36409 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol, PP242::CID24905147::US10172858, Table 2.1::US9828378, # 1 Serine/threonine-protein kinase B-raf Homo sapiens 1600 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36409&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search P2X 4JT5 24905147 117643995 ZINC36056301 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50676839 COc1c(Cl)cc2c3ccncc3[nH]c2c1NC(=O)c1cccnc1C InChI=1S/C19H15ClN4O2/c1-10-11(4-3-6-22-10)19(25)24-17-16-13(8-14(20)18(17)26-2)12-5-7-21-9-15(12)23-16/h3-9,23H,1-2H3,(H,24,25) ZNOLRTPMNMPLHY-UHFFFAOYSA-N 50309910 CHEMBL608154::ML-120B::N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylnicotinamide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50309910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50309910&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9929127 104164271 CHEMBL608154 5694 ZINC06717113 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50689718 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50669625 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Serine/threonine-protein kinase B-raf Homo sapiens 2700 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50675479 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 260 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50676953 CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ RITAVMQDGBJQJZ-FMIVXFBMSA-N 25117 AG-013736::AXITINIB::N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide::US10464902, Axitinib::US9205078, Axitinib ::US9617222, Compound A Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25117&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 6450551 56374259 66910 5659 ZINC03816287 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50682656 CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+ JWNPDZNEKVCWMY-VQHVLOKHSA-N 50161957 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide::CHEMBL180022::HKI-272::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide::NERATINIB::US10822334, Compound Neratinib Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50161957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50161957&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9915743 104048227 CHEMBL180022 5686 ZINC03916214 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50686795 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50691325 Cc1cnc2c(NCCN)nc3ccc(C)cc3n12 InChI=1S/C14H17N5/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18) PSPFQEBFYXJZEV-UHFFFAOYSA-N 25919 BMS-345541::BMS345541::CHEMBL471496::N-(2-aminoethyl)-3,12-dimethyl-2,5,8-triazatricyclo[7.4.0.0^{2,6}]trideca-1(13),3,5,7,9,11-hexaen-7-amine Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25919&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9813758 56413207 CHEMBL471496 5669 ZINC13285379 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50672606 Fc1ccc(C(=O)NOCC2CC2)c(Nc2ccc(I)cc2Cl)c1F InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24) GFMMXOIFOQCCGU-UHFFFAOYSA-N 50132260 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide::2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide::CHEMBL105442::CI-1040::PD-18435::PD-184352::US8575391, 341 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50132260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50132260&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 6918454 104023279 CHEMBL105442 5676 ZINC01489691 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50674127 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50678405 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Serine/threonine-protein kinase B-raf Homo sapiens 1600 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50688510 COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)NC4=CCC(F)C=C4)cc3F)ccnc2cc1OCCCN1CCOCC1 InChI=1S/C34H36F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3,5-9,12,19-22H,2,4,10-11,13-18H2,1H3,(H,38,41)(H,39,42) SEJGTFPOEJWEGG-UHFFFAOYSA-N 50355504 CHEMBL1908393 Serine/threonine-protein kinase B-raf Homo sapiens 2300 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355504&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57399640 136959528 CHEMBL1908393 ZINC73140828 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50689930 C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1 WCWUXEGQKLTGDX-LLVKDONJSA-N 50184807 (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol::(R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol::BMS-540215::CHEMBL377300 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50184807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50184807&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11234052 104069124 CHEMBL377300 5671 ZINC13684256 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50672873 CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26) VAARYSWULJUGST-UHFFFAOYSA-N 6568 6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfanyl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL386051::PD-173955::PD173955::US11136333, Compound PD173955 Serine/threonine-protein kinase B-raf Homo sapiens 4.4 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6568&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search P17 1M52,5IA3 447077 8036145 49791 CHEMBL386051 DB02567 5699 ZINC02047743 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50684309 Clc1cccc(Cl)c1C(=O)Nc1cn[nH]c1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 24654 4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-pyrazole-3,4-diamido::AT7519::JMC514986 Compound 33::pyrazole diamide, 33 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24654&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 56269605 5662 ZINC16052857 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50672964 O=C(N1CCNCC1)c1ccc(\C=C\c2n[nH]c3ccccc23)cc1 InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+ YYLKKYCXAOBSRM-JXMROGBWSA-N 50355496 CHEMBL1908397 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355496&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11427553 136959520 CHEMBL1908397 ZINC43201999 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50674398 CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1 InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27) LHNIIDJUOCFXAP-UHFFFAOYSA-N 25028 4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine::GDC-0941::GDC0941::US10112932, pictilisib::US10851091, Compound pictilisib Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25028&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search GD9 3DBS,2Y3A,2WXP 17755052 56374172 65326 ZINC16052714 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50681526 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) YZDJQTHVDDOVHR-UHFFFAOYSA-N 25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720 Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25617&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 324 3C4C,4WO5 24180719 56412907 DB06999 5703 ZINC39059267 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50690294 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50674460 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Serine/threonine-protein kinase B-raf Homo sapiens 2300 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50674570 Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4ncccc4c3)n2n1 InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 BCZUAADEACICHN-UHFFFAOYSA-N 60589 6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline (4)::BDBM50355498 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60589&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search SX8 3DKF,3DKG 16187854 24782328 DB08584 ZINC15962404 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50684525 Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1 InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24) UJIAQDJKSXQLIT-UHFFFAOYSA-N 25084 3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol::JMC504279 Compound 6::TG100-115 Serine/threonine-protein kinase B-raf Homo sapiens 2100 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25084&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search B6J 5WNK 10427712 56374226 5715 ZINC06718666 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50670190 COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1 InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35) QQWUGDVOUVUTOY-UHFFFAOYSA-N 482158 BDBM50242742::TAE684 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=482158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=482158&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16038120 443551321 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50670224 CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 KGPGFQWBCSZGEL-ZDUSSCGKSA-N 25013 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol::GSK-690693::GSK690693::US10550114, Compound GSK690693 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25013&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search G93 3D0E,5U94 16725726 56374157 5196 ZINC34285211 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50676047 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Serine/threonine-protein kinase B-raf Homo sapiens 500 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50685962 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Serine/threonine-protein kinase B-raf Homo sapiens 280 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50684714 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50684804 OCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,18,24H,2,4,9-10H2 RIGIGAFKKVBACY-UHFFFAOYSA-N 25628 2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethan-1-ol::AR00341677::CHEMBL525191::GDC-0879 Serine/threonine-protein kinase B-raf Homo sapiens 0.180000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25628&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91448975 56412918 CHEMBL525191 ZINC34640412 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50687700 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50692018 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50671968 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50674838 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50680537 CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 50322823 (S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide::AFATINIB::CHEMBL1173655::US10085983, Compound BIBW2992::US10196365, Afatinib::US10435400, Compound BIBW2992::US9388170, Afatinib::US9890168, Compound BIBW2992::WO2022090481, Example afatinib Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322823&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 0WM 4G5J 10184653 104144352 61390 CHEMBL1173655 DB08916 5667 ZINC03976838 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50687780 N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 50355501 INCB-018424::RUXOLITINIB::RUXOLITINIB PHOSPHATE::US10112907, Example 00016::US10766894, Compound TABLE 1.1::US10875847, Compound JAKAFI::US11203595, TABLE 1.1::US11279703, TABLE 6.147 Serine/threonine-protein kinase B-raf Homo sapiens 2200 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355501&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search RXT 6VNK,6WTN,6VGL,4U5J,7F3G 25126798 136959525 66919 DB08877 ZINC43207851 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50670565 COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 InChI=1S/C24H24N4O5S/c1-14(23-26-9-10-34-23)27-24(29)28-17-6-5-15(11-20(17)30-2)33-19-7-8-25-18-13-22(32-4)21(31-3)12-16(18)19/h5-14H,1-4H3,(H2,27,28,29) SHPFDGWALWEPGS-UHFFFAOYSA-N 50355494 CHEMBL1908396 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355494&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9869779 136959518 CHEMBL1908396 ZINC13975055 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50677849 Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) CYOHGALHFOKKQC-UHFFFAOYSA-N 50355497 AZD-6244::CHEMBL1614701 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355497&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 3EW 4U7Z,7JUZ,7JUT,7M0T 10127622 136959521 CHEMBL1614701 ZINC31773258 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50679264 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 ZHJGWYRLJUCMRT-QGZVFWFLSA-N 50355500 CHEMBL1908394::US9695172, GSK461364 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355500&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 15983966 136959524 CHEMBL1908394 ZINC43154472 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50682252 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50690883 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50677990 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50686427 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50670699 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50675247 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50678172 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50680958 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1 OYONTEXKYJZFHA-SSHUPFPWSA-N 50242737 (R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one::CHEMBL450786::PHA-665752::TCMDC-125885 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242737&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10461815 104099202 CHEMBL450786 5700 ZINC03938668 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50695276 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50692580 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31) JOOXLOJCABQBSG-UHFFFAOYSA-N 50332294 CHEMBL1287853::N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide::US10112907, Example 00018::US10730860, TABLE 1.3::US10766894, Compound TABLE 1.3::US11203595, TABLE 1.3::US11384069, Example T-5 Serine/threonine-protein kinase B-raf Homo sapiens 9300 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332294&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2TA 4OGJ,4PS5,6VNE 16722836 123111409 CHEMBL1287853 5716 ZINC19862646 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50696760 COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3 XXJWYDDUDKYVKI-UHFFFAOYSA-N 50331096 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline::CHEMBL491473::Cediranib::US10464902, Cediranib::ZD-2171 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331096&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9933475 123110211 CHEMBL491473 DB04849 5664 ZINC03948085 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50694281 CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34) GUBJNPWVIUFSTR-UHFFFAOYSA-N 50355499 CHEMBL1908395::CHEMBL1908842 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355499&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11676971 136959523 CHEMBL1908842CHEMBL1908395 ZINC38226716 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704510 CC(C)(O)CC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(c4)C(F)(F)F)c(Cl)c3)c12 InChI=1S/C26H25ClF3N5O3/c1-25(2,37)14-22(36)31-9-11-35-10-8-20-23(35)24(33-15-32-20)34-17-6-7-21(19(27)13-17)38-18-5-3-4-16(12-18)26(28,29)30/h3-8,10,12-13,15,37H,9,11,14H2,1-2H3,(H,31,36)(H,32,33,34) ZYQXEVJIFYIBHZ-UHFFFAOYSA-N 50358430 CHEMBL1614725 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1021/jm2008634 10.7270/Q23R0T93 22003817 Ishikawa, T; Seto, M; Banno, H; Kawakita, Y; Oorui, M; Taniguchi, T; Ohta, Y; Tamura, T; Nakayama, A; Miki, H; Kamiguchi, H; Tanaka, T; Habuka, N; Sogabe, S; Yano, J; Aertgeerts, K; Kamiyama, K Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358430&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 03P 3RCD,3W2O,3POZ 11620908 136962454 CHEMBL1614725 ZINC64746555 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50695792 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50695807 C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 50306682 (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-(2,6-dichloro-3-fluorobenzyloxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine::CHEMBL601719::CRIZOTINIB::PF-2341066::US10370379, Crizotinib::US10543199, Compound Crizotinib::US10780082, Compound Crizotinib::US11059827, Compound Crizotinib::US11517561, Compound Crizotinib::US9126941, PF-2341066::US9199944, Crizotinib::US9226923, Crizotinib Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306682&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search VGH 2YFX,5AAA,5AAC,5AAB,4ANS,4ANQ,2XP2,2WGJ,3ZBF,4C9W,6IMZ 11626560 104161043 64310 CHEMBL601719 DB08700 4903 ZINC35902489 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50695868 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Serine/threonine-protein kinase B-raf Homo sapiens 530 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50695925 COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31) UBPYILGKFZZVDX-UHFFFAOYSA-N 4552 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile::4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile::BOSUTINIB::CHEMBL288441::SKI-606 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4552&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search DB8 6OP9,5AJQ,4MXO,4MXY,4MXX,4MXZ,3SOA,5VC3,6FDY,5I9X,3UE4,4QMN,5VCY 5328940 8034215 39112 CHEMBL288441 DB06616 5710 ZINC22448983 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50693323 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50693369 COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24) JRNJNYBQQYBCLE-UHFFFAOYSA-N 12621 2,4-Diamino-5-ketopyrimidine 39::5-[(2,3-difluoro-6-methoxyphenyl)carbonyl]-2-N-(1-methanesulfonylpiperidin-4-yl)pyrimidine-2,4-diamine::R547::[4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12621&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search LIA 2FVD 6918852 46513075 DB08094 5707 ZINC13983251 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50697476 Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37) HHZIURLSWUIHRB-UHFFFAOYSA-N 50237710 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide::AMN 107::AMN107::CHEMBL255863::NILOTINIB::US11649218, Example Nilotinib Serine/threonine-protein kinase B-raf Homo sapiens 570 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50237710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50237710&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search NIL 5MO4,3CS9,3GP0 644241 104056419 52172 CHEMBL255863 DB04868 5697 ZINC06716957 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709880 COc1cncc(c1)-c1nc(NC(C)(C)CO)nc2sc(C(N)=O)c(N)c12 InChI=1S/C17H20N6O3S/c1-17(2,7-24)23-16-21-12(8-4-9(26-3)6-20-5-8)10-11(18)13(14(19)25)27-15(10)22-16/h4-6,24H,7,18H2,1-3H3,(H2,19,25)(H,21,22,23) DFXKHCHQBQBUFT-UHFFFAOYSA-N 50360769 CHEMBL1934652 Serine/threonine-protein kinase B-raf Homo sapiens 1010 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360769&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 56834881 136964831 CHEMBL1934652 ZINC73223726 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709881 COc1cncc(c1)-c1nc(N[C@H](C)CO)nc2sc(C(N)=O)c(N)c12 InChI=1S/C16H18N6O3S/c1-7(6-23)20-16-21-12(8-3-9(25-2)5-19-4-8)10-11(17)13(14(18)24)26-15(10)22-16/h3-5,7,23H,6,17H2,1-2H3,(H2,18,24)(H,20,21,22)/t7-/m1/s1 KPTVKDXGYFKKAX-SSDOTTSWSA-N 50360770 CHEMBL1934651 Serine/threonine-protein kinase B-raf Homo sapiens 2510 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360770&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57397876 136964832 CHEMBL1934651 ZINC73223723 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709882 NC(=O)c1sc2ncnc(-c3cccc(NC(=O)Nc4ccc(cc4)C(F)(F)F)c3)c2c1N InChI=1S/C21H15F3N6O2S/c22-21(23,24)11-4-6-12(7-5-11)29-20(32)30-13-3-1-2-10(8-13)16-14-15(25)17(18(26)31)33-19(14)28-9-27-16/h1-9H,25H2,(H2,26,31)(H2,29,30,32) WIXLTAQIFOIEBA-UHFFFAOYSA-N 50360771 CHEMBL1934650 Serine/threonine-protein kinase B-raf Homo sapiens 327 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360771&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57403038 136964833 CHEMBL1934650 ZINC73225060 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709883 CC(C)(CO)Nc1nc(-c2cccc(NC(=O)Nc3ccc(cc3)C(F)(F)F)c2)c2c(N)c(sc2n1)C(N)=O InChI=1S/C25H24F3N7O3S/c1-24(2,11-36)35-22-33-18(16-17(29)19(20(30)37)39-21(16)34-22)12-4-3-5-15(10-12)32-23(38)31-14-8-6-13(7-9-14)25(26,27)28/h3-10,36H,11,29H2,1-2H3,(H2,30,37)(H2,31,32,38)(H,33,34,35) HRGJRSOYRDLURW-UHFFFAOYSA-N 50360772 CHEMBL1934649 Serine/threonine-protein kinase B-raf Homo sapiens 1540 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360772&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57403037 136964834 CHEMBL1934649 ZINC73225059 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709884 CC(C)(CO)Nc1nc(-c2cccc(O)c2F)c2c(N)c(sc2n1)C(N)=O InChI=1S/C17H18FN5O3S/c1-17(2,6-24)23-16-21-12(7-4-3-5-8(25)10(7)18)9-11(19)13(14(20)26)27-15(9)22-16/h3-5,24-25H,6,19H2,1-2H3,(H2,20,26)(H,21,22,23) ZHZSFNJGNIJMDB-UHFFFAOYSA-N 50360773 CHEMBL1934648 Serine/threonine-protein kinase B-raf Homo sapiens 332 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360773&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57399528 136964835 CHEMBL1934648 ZINC73223466 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709885 CC(C)(CO)Nc1nc(-c2cc(O)cc(Cl)c2)c2c(N)c(sc2n1)C(N)=O InChI=1S/C17H18ClN5O3S/c1-17(2,6-24)23-16-21-12(7-3-8(18)5-9(25)4-7)10-11(19)13(14(20)26)27-15(10)22-16/h3-5,24-25H,6,19H2,1-2H3,(H2,20,26)(H,21,22,23) IEIWULTUQINCEL-UHFFFAOYSA-N 50360774 CHEMBL1934647 Serine/threonine-protein kinase B-raf Homo sapiens 103 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360774&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57392593 136964836 CHEMBL1934647 ZINC82157990 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709886 NC(=O)c1sc2nc(NC3CC3)nc(-c3cccc(NC(=O)Nc4ccc(cc4)C(F)(F)F)c3)c2c1N InChI=1S/C24H20F3N7O2S/c25-24(26,27)12-4-6-14(7-5-12)31-23(36)32-15-3-1-2-11(10-15)18-16-17(28)19(20(29)35)37-21(16)34-22(33-18)30-13-8-9-13/h1-7,10,13H,8-9,28H2,(H2,29,35)(H,30,33,34)(H2,31,32,36) RVPNRQPMZBNTBC-UHFFFAOYSA-N 50360775 CHEMBL1934646 Serine/threonine-protein kinase B-raf Homo sapiens 546 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360775&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57390781 136964837 CHEMBL1934646 ZINC73386563 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709887 Cc1ccc(NC(=O)Nc2cccc(c2)-c2nc(NC3CC3)nc3sc(C(N)=O)c(N)c23)cc1 InChI=1S/C24H23N7O2S/c1-12-5-7-15(8-6-12)28-24(33)29-16-4-2-3-13(11-16)19-17-18(25)20(21(26)32)34-22(17)31-23(30-19)27-14-9-10-14/h2-8,11,14H,9-10,25H2,1H3,(H2,26,32)(H,27,30,31)(H2,28,29,33) QQZZOEDJZWYVGQ-UHFFFAOYSA-N 50360776 CHEMBL1934645 Serine/threonine-protein kinase B-raf Homo sapiens 2030 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360776&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57397875 136964838 CHEMBL1934645 ZINC82157989 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709888 NC(=O)c1sc2nc(NC3CC3)nc(-c3cccc(NC(=O)Nc4ccccc4)c3)c2c1N InChI=1S/C23H21N7O2S/c24-17-16-18(29-22(26-14-9-10-14)30-21(16)33-19(17)20(25)31)12-5-4-8-15(11-12)28-23(32)27-13-6-2-1-3-7-13/h1-8,11,14H,9-10,24H2,(H2,25,31)(H,26,29,30)(H2,27,28,32) PXXXCHFVIAQAAK-UHFFFAOYSA-N 50360777 CHEMBL1934644 Serine/threonine-protein kinase B-raf Homo sapiens 10100 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360777&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57390780 136964839 CHEMBL1934644 ZINC73220000 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704977 CN(C)CCOc1ccc(cc1)-c1nc(c([nH]1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1 InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,24H,6,10,15-16H2,1-2H3,(H,29,30) ZLWRKMXLUCZVAR-UHFFFAOYSA-N 25391 CHEMBL200622::SB-590885::SB590885::[2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)-1H-imidazol-2-yl}phenoxy)ethyl]dimethylamine Serine/threonine-protein kinase B-raf Homo sapiens 0.16 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25391&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2FB8 91369525 56374530 CHEMBL200622 ZINC89224159 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704978 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 22 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704979 NC(=O)c1ccc2[nH]cc(-c3cccc(O)c3)c2c1 InChI=1S/C15H12N2O2/c16-15(19)10-4-5-14-12(7-10)13(8-17-14)9-2-1-3-11(18)6-9/h1-8,17-18H,(H2,16,19) XBGHGUGFJFWTAY-UHFFFAOYSA-N 50358754 CHEMBL1922467 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358754&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57403706 136962778 CHEMBL1922467 ZINC73168105 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704980 Oc1cccc(c1)-c1c[nH]c2cc3C(=O)NC(=O)c3cc12 InChI=1S/C16H10N2O3/c19-9-3-1-2-8(4-9)13-7-17-14-6-12-11(5-10(13)14)15(20)18-16(12)21/h1-7,17,19H,(H,18,20,21) GXANGPSTEUHEEY-UHFFFAOYSA-N 50358755 CHEMBL1922468 Serine/threonine-protein kinase B-raf Homo sapiens 3470 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358755&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57403707 136962779 CHEMBL1922468 ZINC73168107 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704981 Oc1cccc(Nc2cc3C(=O)NC(=O)c3cc2Nc2cccc(O)c2)c1 InChI=1S/C20H15N3O4/c24-13-5-1-3-11(7-13)21-17-9-15-16(20(27)23-19(15)26)10-18(17)22-12-4-2-6-14(25)8-12/h1-10,21-22,24-25H,(H,23,26,27) VBXMMKOVEQTSID-UHFFFAOYSA-N 50358756 CHEMBL1922469 Serine/threonine-protein kinase B-raf Homo sapiens 338 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358756&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 22918445 136962780 CHEMBL1922469 ZINC73169904 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704982 Oc1cccc(Nc2cc3C(=O)NC(=O)c3cc2Nc2ccccc2)c1 InChI=1S/C20H15N3O3/c24-14-8-4-7-13(9-14)22-18-11-16-15(19(25)23-20(16)26)10-17(18)21-12-5-2-1-3-6-12/h1-11,21-22,24H,(H,23,25,26) JZUCYMSNLMXCKV-UHFFFAOYSA-N 50358757 CHEMBL1922470 Serine/threonine-protein kinase B-raf Homo sapiens 1680 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358757&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57396728 136962781 CHEMBL1922470 ZINC73169906 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704983 Oc1cccc(Nc2cc3c(cc2Nc2ccccc2)c(=O)[nH][nH]c3=O)c1 InChI=1S/C20H16N4O3/c25-14-8-4-7-13(9-14)22-18-11-16-15(19(26)23-24-20(16)27)10-17(18)21-12-5-2-1-3-6-12/h1-11,21-22,25H,(H,23,26)(H,24,27) VGYRNENCHYJBJO-UHFFFAOYSA-N 50358758 CHEMBL1922471 Serine/threonine-protein kinase B-raf Homo sapiens 3770 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358758&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57403708 136962782 CHEMBL1922471 ZINC73169908 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704984 Oc1cccc(Nc2cc3c(cc2Nc2cccc(O)c2)c(=O)[nH][nH]c3=O)c1 InChI=1S/C20H16N4O4/c25-13-5-1-3-11(7-13)21-17-9-15-16(20(28)24-23-19(15)27)10-18(17)22-12-4-2-6-14(26)8-12/h1-10,21-22,25-26H,(H,23,27)(H,24,28) YMDDDFHRBBCGOK-UHFFFAOYSA-N 50358759 CHEMBL1922472 Serine/threonine-protein kinase B-raf Homo sapiens 290 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358759&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57393255 136962783 CHEMBL1922472 ZINC73169910 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704985 Clc1cccc(c1)C(=O)Nc1cccc(Nc2cc3C(=O)NC(=O)c3cc2Cl)c1 InChI=1S/C21H13Cl2N3O3/c22-12-4-1-3-11(7-12)19(27)25-14-6-2-5-13(8-14)24-18-10-16-15(9-17(18)23)20(28)26-21(16)29/h1-10,24H,(H,25,27)(H,26,28,29) KABJVMJWLHOYFO-UHFFFAOYSA-N 50358760 CHEMBL1922473 Serine/threonine-protein kinase B-raf Homo sapiens 117 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358760&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57398497 136962784 CHEMBL1922473 ZINC73166666 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704986 Clc1cc2C(=O)NC(=O)c2cc1Nc1cccc(NC(=O)c2cccc(Br)c2)c1 InChI=1S/C21H13BrClN3O3/c22-12-4-1-3-11(7-12)19(27)25-14-6-2-5-13(8-14)24-18-10-16-15(9-17(18)23)20(28)26-21(16)29/h1-10,24H,(H,25,27)(H,26,28,29) UZTAAWAQVIBPOP-UHFFFAOYSA-N 50358761 CHEMBL1922474 Serine/threonine-protein kinase B-raf Homo sapiens 35 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358761&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57398498 136962785 CHEMBL1922474 ZINC73387850 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704987 Clc1cc2C(=O)NC(=O)c2cc1Nc1cccc(NC(=O)c2cccc(I)c2)c1 InChI=1S/C21H13ClIN3O3/c22-17-9-15-16(21(29)26-20(15)28)10-18(17)24-13-5-2-6-14(8-13)25-19(27)11-3-1-4-12(23)7-11/h1-10,24H,(H,25,27)(H,26,28,29) NQTHPBZIGQQCGW-UHFFFAOYSA-N 50358762 CHEMBL1922475 Serine/threonine-protein kinase B-raf Homo sapiens 8 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358762&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54764764 136962786 CHEMBL1922475 ZINC73166668 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704988 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Nc2cc3C(=O)NC(=O)c3cc2Cl)c1 InChI=1S/C22H13ClF3N3O3/c23-17-9-15-16(21(32)29-20(15)31)10-18(17)27-13-5-2-6-14(8-13)28-19(30)11-3-1-4-12(7-11)22(24,25)26/h1-10,27H,(H,28,30)(H,29,31,32) LMWCSKRGOYUZCO-UHFFFAOYSA-N 50358763 CHEMBL1922476 Serine/threonine-protein kinase B-raf Homo sapiens 10 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358763&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54764765 136962787 CHEMBL1922476 ZINC73166671 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704989 FC(F)(F)Oc1cccc(c1)C(=O)Nc1cccc(Nc2cc3C(=O)NC(=O)c3cc2Cl)c1 InChI=1S/C22H13ClF3N3O4/c23-17-9-15-16(21(32)29-20(15)31)10-18(17)27-12-4-2-5-13(8-12)28-19(30)11-3-1-6-14(7-11)33-22(24,25)26/h1-10,27H,(H,28,30)(H,29,31,32) CJLDGBQQZQUIPT-UHFFFAOYSA-N 50358764 CHEMBL1922591 Serine/threonine-protein kinase B-raf Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358764&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54764766 136962788 CHEMBL1922591 ZINC73164140 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704990 Clc1cc2C(=O)NC(=O)c2cc1Nc1cccc(NC(=O)c2cccc(c2)C#N)c1 InChI=1S/C22H13ClN4O3/c23-18-9-16-17(22(30)27-21(16)29)10-19(18)25-14-5-2-6-15(8-14)26-20(28)13-4-1-3-12(7-13)11-24/h1-10,25H,(H,26,28)(H,27,29,30) LCKAUCGMDOLLMT-UHFFFAOYSA-N 50358765 CHEMBL1922592 Serine/threonine-protein kinase B-raf Homo sapiens 297 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358765&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57400186 136962789 CHEMBL1922592 ZINC73164143 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704991 Cn1nc(cc1C(=O)Nc1cccc(Nc2cc3C(=O)NC(=O)c3cc2Cl)c1)C(C)(C)C InChI=1S/C23H22ClN5O3/c1-23(2,3)19-11-18(29(4)28-19)22(32)26-13-7-5-6-12(8-13)25-17-10-15-14(9-16(17)24)20(30)27-21(15)31/h5-11,25H,1-4H3,(H,26,32)(H,27,30,31) SZTZVLFQNRQRKS-UHFFFAOYSA-N 50358766 CHEMBL1922593 Serine/threonine-protein kinase B-raf Homo sapiens 349 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358766&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57394998 136962790 CHEMBL1922593 ZINC73164147 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704992 Clc1cccc(c1)C(=O)Nc1cccc(Nc2cc3c(cc2Cl)c(=O)[nH][nH]c3=O)c1 InChI=1S/C21H14Cl2N4O3/c22-12-4-1-3-11(7-12)19(28)25-14-6-2-5-13(8-14)24-18-10-16-15(9-17(18)23)20(29)26-27-21(16)30/h1-10,24H,(H,25,28)(H,26,29)(H,27,30) XURROYCEKBIIOJ-UHFFFAOYSA-N 50358767 CHEMBL1922594 Serine/threonine-protein kinase B-raf Homo sapiens 35 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358767&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57398516 136962791 CHEMBL1922594 ZINC73164150 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704993 Clc1cc2c(cc1Nc1cccc(NC(=O)c3cccc(Br)c3)c1)c(=O)[nH][nH]c2=O InChI=1S/C21H14BrClN4O3/c22-12-4-1-3-11(7-12)19(28)25-14-6-2-5-13(8-14)24-18-10-16-15(9-17(18)23)20(29)26-27-21(16)30/h1-10,24H,(H,25,28)(H,26,29)(H,27,30) OFJLOYNZQDQGGW-UHFFFAOYSA-N 50358768 CHEMBL1922595 Serine/threonine-protein kinase B-raf Homo sapiens 19 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358768&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57403736 136962792 CHEMBL1922595 ZINC73164152 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704994 Clc1cc2c(cc1Nc1cccc(NC(=O)c3cccc(I)c3)c1)c(=O)[nH][nH]c2=O InChI=1S/C21H14ClIN4O3/c22-17-9-15-16(21(30)27-26-20(15)29)10-18(17)24-13-5-2-6-14(8-13)25-19(28)11-3-1-4-12(23)7-11/h1-10,24H,(H,25,28)(H,26,29)(H,27,30) IESVGVCLYIUCSJ-UHFFFAOYSA-N 50358769 CHEMBL1922596 Serine/threonine-protein kinase B-raf Homo sapiens 8 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358769&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54764768 136962793 CHEMBL1922596 ZINC73164155 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704995 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Nc2cc3c(cc2Cl)c(=O)[nH][nH]c3=O)c1 InChI=1S/C22H14ClF3N4O3/c23-17-9-15-16(21(33)30-29-20(15)32)10-18(17)27-13-5-2-6-14(8-13)28-19(31)11-3-1-4-12(7-11)22(24,25)26/h1-10,27H,(H,28,31)(H,29,32)(H,30,33) FAGAPNVOWYRNED-UHFFFAOYSA-N 50358770 CHEMBL1922597 Serine/threonine-protein kinase B-raf Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358770&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 54764767 136962794 CHEMBL1922597 ZINC73169422 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704996 FC(F)(F)Oc1cccc(c1)C(=O)Nc1cccc(Nc2cc3c(cc2Cl)c(=O)[nH][nH]c3=O)c1 InChI=1S/C22H14ClF3N4O4/c23-17-9-15-16(21(33)30-29-20(15)32)10-18(17)27-12-4-2-5-13(8-12)28-19(31)11-3-1-6-14(7-11)34-22(24,25)26/h1-10,27H,(H,28,31)(H,29,32)(H,30,33) TUHQCFIFPPXTLF-UHFFFAOYSA-N 50358771 CHEMBL1922598 Serine/threonine-protein kinase B-raf Homo sapiens 18 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358771&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57400171 136962795 CHEMBL1922598 ZINC73169424 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704997 Clc1cc2c(cc1Nc1cccc(NC(=O)c3cccc(c3)C#N)c1)c(=O)[nH][nH]c2=O InChI=1S/C22H14ClN5O3/c23-18-9-16-17(22(31)28-27-21(16)30)10-19(18)25-14-5-2-6-15(8-14)26-20(29)13-4-1-3-12(7-13)11-24/h1-10,25H,(H,26,29)(H,27,30)(H,28,31) DOSASLICLCWVOI-UHFFFAOYSA-N 50358772 CHEMBL1922599 Serine/threonine-protein kinase B-raf Homo sapiens 296 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358772&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57401958 136962796 CHEMBL1922599 ZINC73169426 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50704998 Cn1nc(cc1C(=O)Nc1cccc(Nc2cc3c(cc2Cl)c(=O)[nH][nH]c3=O)c1)C(C)(C)C InChI=1S/C23H23ClN6O3/c1-23(2,3)19-11-18(30(4)29-19)22(33)26-13-7-5-6-12(8-13)25-17-10-15-14(9-16(17)24)20(31)27-28-21(15)32/h5-11,25H,1-4H3,(H,26,33)(H,27,31)(H,28,32) ZQEBCHADYFBOIT-UHFFFAOYSA-N 50358773 CHEMBL1922600 Serine/threonine-protein kinase B-raf Homo sapiens 293 ChEMBL 10.1016/j.bmcl.2011.10.012 10.7270/Q21R6QXK 22024030 Wang, X; Salaski, EJ; Berger, DM; Powell, D; Hu, Y; Wojciechowicz, D; Collins, K; Frommer, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358773&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57401959 136962797 CHEMBL1922600 ZINC73169428 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709892 NC(=O)c1sc2nc(NC3CC3)nc(-c3ccc(Cl)c(O)c3)c2c1N InChI=1S/C16H14ClN5O2S/c17-8-4-1-6(5-9(8)23)12-10-11(18)13(14(19)24)25-15(10)22-16(21-12)20-7-2-3-7/h1,4-5,7,23H,2-3,18H2,(H2,19,24)(H,20,21,22) MXIYRKZKZZAVHV-UHFFFAOYSA-N 50360781 CHEMBL1934514 Serine/threonine-protein kinase B-raf Homo sapiens 271 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360781&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57399562 136964843 CHEMBL1934514 ZINC73240602 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709893 NC(=O)c1sc2nc(NC3CC3)nc(-c3cc(O)cc(Cl)c3)c2c1N InChI=1S/C16H14ClN5O2S/c17-7-3-6(4-9(23)5-7)12-10-11(18)13(14(19)24)25-15(10)22-16(21-12)20-8-1-2-8/h3-5,8,23H,1-2,18H2,(H2,19,24)(H,20,21,22) WCYRSSJUYMQAFK-UHFFFAOYSA-N 50360782 CHEMBL1934513 Serine/threonine-protein kinase B-raf Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360782&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 56834882 136964844 CHEMBL1934513 ZINC73240600 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709894 COc1cccc(c1)-c1nc(NC2CC2)nc2sc(C(N)=O)c(N)c12 InChI=1S/C17H17N5O2S/c1-24-10-4-2-3-8(7-10)13-11-12(18)14(15(19)23)25-16(11)22-17(21-13)20-9-5-6-9/h2-4,7,9H,5-6,18H2,1H3,(H2,19,23)(H,20,21,22) UXOZSZOFORSOHH-UHFFFAOYSA-N 50360783 CHEMBL1934510 Serine/threonine-protein kinase B-raf Homo sapiens 11700 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360783&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57397920 136964845 CHEMBL1934510 ZINC73219707 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709895 NC(=O)c1sc2nc(NC3CC3)nc(-c3ccc(O)cc3)c2c1N InChI=1S/C16H15N5O2S/c17-11-10-12(7-1-5-9(22)6-2-7)20-16(19-8-3-4-8)21-15(10)24-13(11)14(18)23/h1-2,5-6,8,22H,3-4,17H2,(H2,18,23)(H,19,20,21) NEMWWYYQAACTEU-UHFFFAOYSA-N 50360784 CHEMBL1934509 Serine/threonine-protein kinase B-raf Homo sapiens 13900 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360784&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57394354 136964846 CHEMBL1934509 ZINC73223731 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709896 NC(=O)c1sc2nc(NC3CC3)nc(-c3cccc(O)c3)c2c1N InChI=1S/C16H15N5O2S/c17-11-10-12(7-2-1-3-9(22)6-7)20-16(19-8-4-5-8)21-15(10)24-13(11)14(18)23/h1-3,6,8,22H,4-5,17H2,(H2,18,23)(H,19,20,21) SSGFQWJVEGWBGZ-UHFFFAOYSA-N 50360785 CHEMBL1934508 Serine/threonine-protein kinase B-raf Homo sapiens 212 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360785&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57392635 136964847 CHEMBL1934508 ZINC73222933 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709897 C[C@H](CO)Cc1nc(-c2ccc(Cl)c(Cl)c2)c2c(N)c(sc2n1)C(N)=O InChI=1S/C17H16Cl2N4O2S/c1-7(6-24)4-11-22-14(8-2-3-9(18)10(19)5-8)12-13(20)15(16(21)25)26-17(12)23-11/h2-3,5,7,24H,4,6,20H2,1H3,(H2,21,25)/t7-/m0/s1 RBBKRVZWWJGYNB-ZETCQYMHSA-N 50360786 CHEMBL1934506 Serine/threonine-protein kinase B-raf Homo sapiens 14500 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360786&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57397919 136964848 CHEMBL1934506 ZINC73223728 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709898 C[C@H](CO)Oc1nc(-c2ccc(Cl)c(Cl)c2)c2c(N)c(sc2n1)C(N)=O InChI=1S/C16H14Cl2N4O3S/c1-6(5-23)25-16-21-12(7-2-3-8(17)9(18)4-7)10-11(19)13(14(20)24)26-15(10)22-16/h2-4,6,23H,5,19H2,1H3,(H2,20,24)/t6-/m1/s1 FSEMWXQKDZZYOY-ZCFIWIBFSA-N 50360787 CHEMBL1934505 Serine/threonine-protein kinase B-raf Homo sapiens 6880 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360787&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57401316 136964849 CHEMBL1934505 ZINC73220289 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709899 CC(C)(CO)Nc1nc(-c2ccc(Cl)c(Cl)c2)c2c(N)c(sc2n1)C(N)=O InChI=1S/C17H17Cl2N5O2S/c1-17(2,6-25)24-16-22-12(7-3-4-8(18)9(19)5-7)10-11(20)13(14(21)26)27-15(10)23-16/h3-5,25H,6,20H2,1-2H3,(H2,21,26)(H,22,23,24) ARZRIEHPHMHNSV-UHFFFAOYSA-N 50360788 CHEMBL1934504 Serine/threonine-protein kinase B-raf Homo sapiens 9640 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360788&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57396105 136964850 CHEMBL1934504 ZINC73220286 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709900 C[C@H](CO)Nc1nc(-c2ccc(Cl)c(Cl)c2)c2c(N)c(sc2n1)C(N)=O InChI=1S/C16H15Cl2N5O2S/c1-6(5-24)21-16-22-12(7-2-3-8(17)9(18)4-7)10-11(19)13(14(20)25)26-15(10)23-16/h2-4,6,24H,5,19H2,1H3,(H2,20,25)(H,21,22,23)/t6-/m1/s1 KFADAYXCFZGHFB-ZCFIWIBFSA-N 50360789 CHEMBL1934503 Serine/threonine-protein kinase B-raf Homo sapiens 3820 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360789&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57396104 136964851 CHEMBL1934503 ZINC73220283 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709901 NCCNc1nc(-c2ccc(Cl)c(Cl)c2)c2c(N)c(sc2n1)C(N)=O InChI=1S/C15H14Cl2N6OS/c16-7-2-1-6(5-8(7)17)11-9-10(19)12(13(20)24)25-14(9)23-15(22-11)21-4-3-18/h1-2,5H,3-4,18-19H2,(H2,20,24)(H,21,22,23) CGJFBVAQFCVHQT-UHFFFAOYSA-N 50360790 CHEMBL1934502 Serine/threonine-protein kinase B-raf Homo sapiens 9750 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360790&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24737709 136964852 CHEMBL1934502 ZINC73387143 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709902 NC(=O)c1sc2nc(NCCO)nc(-c3ccc(Cl)c(Cl)c3)c2c1N InChI=1S/C15H13Cl2N5O2S/c16-7-2-1-6(5-8(7)17)11-9-10(18)12(13(19)24)25-14(9)22-15(21-11)20-3-4-23/h1-2,5,23H,3-4,18H2,(H2,19,24)(H,20,21,22) BCALWAGTQCFXQT-UHFFFAOYSA-N 50360791 CHEMBL1934501 Serine/threonine-protein kinase B-raf Homo sapiens 7910 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360791&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57401315 136964853 CHEMBL1934501 ZINC73224545 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709903 NC(=O)c1sc2nc(N)nc(-c3ccc(Cl)c(Cl)c3)c2c1N InChI=1S/C13H9Cl2N5OS/c14-5-2-1-4(3-6(5)15)9-7-8(16)10(11(17)21)22-12(7)20-13(18)19-9/h1-3H,16H2,(H2,17,21)(H2,18,19,20) NZSGGOJDVRRWTL-UHFFFAOYSA-N 50360792 CHEMBL1934499 Serine/threonine-protein kinase B-raf Homo sapiens 17600 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360792&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24738496 136964854 CHEMBL1934499 ZINC73222452 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709904 NC(=O)c1sc2ncnc(-c3ccc(Cl)c(Cl)c3)c2c1N InChI=1S/C13H8Cl2N4OS/c14-6-2-1-5(3-7(6)15)10-8-9(16)11(12(17)20)21-13(8)19-4-18-10/h1-4H,16H2,(H2,17,20) VLONXLNAOJWNNV-UHFFFAOYSA-N 50360793 CHEMBL1934498 Serine/threonine-protein kinase B-raf Homo sapiens >60000 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360793&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57401314 136964855 CHEMBL1934498 ZINC73224543 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709905 NC(=O)c1sc2nc(NC3CC3)nc(-c3ccc(Cl)c(Cl)c3)c2c1N InChI=1S/C16H13Cl2N5OS/c17-8-4-1-6(5-9(8)18)12-10-11(19)13(14(20)24)25-15(10)23-16(22-12)21-7-2-3-7/h1,4-5,7H,2-3,19H2,(H2,20,24)(H,21,22,23) QDFKGLKTIPWNOS-UHFFFAOYSA-N 50360794 CHEMBL1934497 Serine/threonine-protein kinase B-raf Homo sapiens 4740 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360794&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24738493 136964856 CHEMBL1934497 ZINC73224542 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709889 COc1cncc(c1)-c1nc(NC2CC2)nc2sc(C(N)=O)c(N)c12 InChI=1S/C16H16N6O2S/c1-24-9-4-7(5-19-6-9)12-10-11(17)13(14(18)23)25-15(10)22-16(21-12)20-8-2-3-8/h4-6,8H,2-3,17H2,1H3,(H2,18,23)(H,20,21,22) ACKXXKJTODHUOX-UHFFFAOYSA-N 50360778 CHEMBL1934641 Serine/threonine-protein kinase B-raf Homo sapiens 685 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360778&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57399527 136964840 CHEMBL1934641 ZINC73219074 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709890 NC(=O)c1sc2nc(NC3CC3)nc(-c3cccc(O)c3F)c2c1N InChI=1S/C16H14FN5O2S/c17-10-7(2-1-3-8(10)23)12-9-11(18)13(14(19)24)25-15(9)22-16(21-12)20-6-4-5-6/h1-3,6,23H,4-5,18H2,(H2,19,24)(H,20,21,22) OFKFQQHRYMZQCK-UHFFFAOYSA-N 50360779 CHEMBL1934516 Serine/threonine-protein kinase B-raf Homo sapiens 111 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360779&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57390813 136964841 CHEMBL1934516 ZINC73240606 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50709891 Cc1ccc(cc1O)-c1nc(NC2CC2)nc2sc(C(N)=O)c(N)c12 InChI=1S/C17H17N5O2S/c1-7-2-3-8(6-10(7)23)13-11-12(18)14(15(19)24)25-16(11)22-17(21-13)20-9-4-5-9/h2-3,6,9,23H,4-5,18H2,1H3,(H2,19,24)(H,20,21,22) DGRUURZRKSORIM-UHFFFAOYSA-N 50360780 CHEMBL1934515 Serine/threonine-protein kinase B-raf Homo sapiens 202 ChEMBL 10.1016/j.bmcl.2011.03.006 10.7270/Q26Q1XP7 22137342 Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360780&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57399563 136964842 CHEMBL1934515 ZINC73240604 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50697709 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Serine/threonine-protein kinase B-raf Homo sapiens 430 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50696374 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Serine/threonine-protein kinase B-raf Homo sapiens 330 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50696425 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50720079 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Serine/threonine-protein kinase B-raf Homo sapiens >4800 ChEMBL 10.1073/pnas.0502000102 10.7270/Q2PC32TB 16249345 Conway, JG; McDonald, B; Parham, J; Keith, B; Rusnak, DW; Shaw, E; Jansen, M; Lin, P; Payne, A; Crosby, RM; Johnson, JH; Frick, L; Lin, MH; Depee, S; Tadepalli, S; Votta, B; James, I; Fuller, K; Chambers, TJ; Kull, FC; Chamberlain, SD; Hutchins, JT GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50722394 CC(C)n1c2CCCC(=O)c2c2C(=O)c3ccccc3-c12 InChI=1S/C18H17NO2/c1-10(2)19-13-8-5-9-14(20)15(13)16-17(19)11-6-3-4-7-12(11)18(16)21/h3-4,6-7,10H,5,8-9H2,1-2H3 DGOKKNPUISUUGY-UHFFFAOYSA-N 50366114 CHEMBL1957190 Serine/threonine-protein kinase B-raf Homo sapiens >35000 ChEMBL 10.1016/j.bmc.2012.02.017 10.7270/Q2J966T6 22377675 Hundsdorfer, C; Hemmerling, HJ; Gotz, C; Totzke, F; Bednarski, P; Le Borgne, M; Jose, J Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366114&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24764502 136970176 CHEMBL1957190 ZINC73297163 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50722395 Oc1cc2c3c(oc(=O)c4cc(O)c(O)c(oc2=O)c34)c1O InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H AFSDNFLWKVMVRB-UHFFFAOYSA-N 4078 6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(14),4(16),5,7,11(15),12-hexaene-3,10-dione::CHEMBL6246::ELLAGIC ACID::Elagic Acid::Ellagic acid (18)::Ellagic acid dihydrate::MLS000069632::SMR000058244::cid_5281855 Serine/threonine-protein kinase B-raf Homo sapiens 1760 ChEMBL 10.1016/j.bmc.2012.02.017 10.7270/Q2J966T6 22377675 Hundsdorfer, C; Hemmerling, HJ; Gotz, C; Totzke, F; Bednarski, P; Le Borgne, M; Jose, J Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4078&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search REF 4YUA,2ZJW,6RWD 5281855 8033769 4775 CHEMBL6246 DB08468 C10788 ZINC03872446 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713290 Cc1ccc(Nc2nncc3c(cccc23)-c2ccc(O)cc2)cc1 InChI=1S/C21H17N3O/c1-14-5-9-16(10-6-14)23-21-19-4-2-3-18(20(19)13-22-24-21)15-7-11-17(25)12-8-15/h2-13,25H,1H3,(H,23,24) WRSYCAPFKMIFHZ-UHFFFAOYSA-N 50362236 CHEMBL1939427 Serine/threonine-protein kinase B-raf Homo sapiens 4700 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362236&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57390174 136966298 CHEMBL1939427 ZINC73239801 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713291 NC(=O)COc1ccc(Nc2nncc3c(cccc23)-c2ccc(O)cc2)cc1 InChI=1S/C22H18N4O3/c23-21(28)13-29-17-10-6-15(7-11-17)25-22-19-3-1-2-18(20(19)12-24-26-22)14-4-8-16(27)9-5-14/h1-12,27H,13H2,(H2,23,28)(H,25,26) DWCYWAJPGFLAPO-UHFFFAOYSA-N 50362237 CHEMBL1939563 Serine/threonine-protein kinase B-raf Homo sapiens 2500 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362237&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 56950792 136966299 CHEMBL1939563 ZINC73196757 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713292 COc1ccc(Nc2nncc3c(cccc23)-c2ccc(O)cc2)cc1 InChI=1S/C21H17N3O2/c1-26-17-11-7-15(8-12-17)23-21-19-4-2-3-18(20(19)13-22-24-21)14-5-9-16(25)10-6-14/h2-13,25H,1H3,(H,23,24) QFVSHLKKHKJSJF-UHFFFAOYSA-N 50362238 CHEMBL1939564 Serine/threonine-protein kinase B-raf Homo sapiens 3700 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362238&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57395430 136966300 CHEMBL1939564 ZINC73161771 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713293 Oc1ccc(cc1)-c1cccc2c(Nc3cccc(O)c3)nncc12 InChI=1S/C20H15N3O2/c24-15-9-7-13(8-10-15)17-5-2-6-18-19(17)12-21-23-20(18)22-14-3-1-4-16(25)11-14/h1-12,24-25H,(H,22,23) KJJJJGFCLQKYQZ-UHFFFAOYSA-N 50362239 CHEMBL1939565 Serine/threonine-protein kinase B-raf Homo sapiens 5100 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362239&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57390210 136966301 CHEMBL1939565 ZINC73161773 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713294 NS(=O)(=O)c1ccc(Nc2nncc3c(cccc23)-c2ccc(O)cc2)cc1 InChI=1S/C20H16N4O3S/c21-28(26,27)16-10-6-14(7-11-16)23-20-18-3-1-2-17(19(18)12-22-24-20)13-4-8-15(25)9-5-13/h1-12,25H,(H,23,24)(H2,21,26,27) CXJQWAGPWRGKHL-UHFFFAOYSA-N 50362240 CHEMBL1939566 Serine/threonine-protein kinase B-raf Homo sapiens 4700 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362240&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57398968 136966302 CHEMBL1939566 ZINC73161775 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713295 NC(=O)Cc1ccc(Nc2nncc3c(cccc23)-c2ccc(O)cc2)cc1 InChI=1S/C22H18N4O2/c23-21(28)12-14-4-8-16(9-5-14)25-22-19-3-1-2-18(20(19)13-24-26-22)15-6-10-17(27)11-7-15/h1-11,13,27H,12H2,(H2,23,28)(H,25,26) UFSQKRZOPVHVKD-UHFFFAOYSA-N 50362241 CHEMBL1939567 Serine/threonine-protein kinase B-raf Homo sapiens 8000 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362241&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57398969 136966303 CHEMBL1939567 ZINC73219166 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713296 CN(C)C(=O)Cc1ccc(cc1)-c1cccc2c(Nc3cccc(O)c3)nncc12 InChI=1S/C24H22N4O2/c1-28(2)23(30)13-16-9-11-17(12-10-16)20-7-4-8-21-22(20)15-25-27-24(21)26-18-5-3-6-19(29)14-18/h3-12,14-15,29H,13H2,1-2H3,(H,26,27) WAELXRGEOHDVCQ-UHFFFAOYSA-N 50362242 CHEMBL1939568 Serine/threonine-protein kinase B-raf Homo sapiens 9600 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362242&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57395431 136966304 CHEMBL1939568 ZINC73195760 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713297 OC(=O)c1ccc(Nc2ncnc3nc[nH]c23)cc1 InChI=1S/C12H9N5O2/c18-12(19)7-1-3-8(4-2-7)17-11-9-10(14-5-13-9)15-6-16-11/h1-6H,(H,18,19)(H2,13,14,15,16,17) HIPVRKVLPDDNQM-UHFFFAOYSA-N 50362243 CHEMBL1939412 Serine/threonine-protein kinase B-raf Homo sapiens 9400 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362243&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 4294777 136966305 CHEMBL1939412 ZINC01669634 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713298 Nc1nc(Nc2cccc(O)c2)c2[nH]cnc2n1 InChI=1S/C11H10N6O/c12-11-16-9-8(13-5-14-9)10(17-11)15-6-2-1-3-7(18)4-6/h1-5,18H,(H4,12,13,14,15,16,17) FFNYAHHFNQZRGG-UHFFFAOYSA-N 50362244 CHEMBL1939413 Serine/threonine-protein kinase B-raf Homo sapiens 5800 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362244&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 39378393 136966306 CHEMBL1939413 ZINC32124485 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713299 Nc1nc(Nc2cccc(Br)c2)c2[nH]cnc2n1 InChI=1S/C11H9BrN6/c12-6-2-1-3-7(4-6)16-10-8-9(15-5-14-8)17-11(13)18-10/h1-5H,(H4,13,14,15,16,17,18) JPVDTQHICMAEST-UHFFFAOYSA-N 50362245 CHEMBL1939414 Serine/threonine-protein kinase B-raf Homo sapiens 2200 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362245&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16415729 136966307 CHEMBL1939414 ZINC09422108 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713300 CCC(=O)c1cccc(Nc2nc(N)nc3nc[nH]c23)c1 InChI=1S/C14H14N6O/c1-2-10(21)8-4-3-5-9(6-8)18-13-11-12(17-7-16-11)19-14(15)20-13/h3-7H,2H2,1H3,(H4,15,16,17,18,19,20) BVILTYTYHCGBMX-UHFFFAOYSA-N 50362246 CHEMBL1939415 Serine/threonine-protein kinase B-raf Homo sapiens 2800 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362246&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57390173 136966308 CHEMBL1939415 ZINC73239874 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713301 COc1ccc(Nc2nc(N)nc3nc[nH]c23)cc1OC InChI=1S/C13H14N6O2/c1-20-8-4-3-7(5-9(8)21-2)17-12-10-11(16-6-15-10)18-13(14)19-12/h3-6H,1-2H3,(H4,14,15,16,17,18,19) YBARUCSMZRAWCH-UHFFFAOYSA-N 50362247 CHEMBL1939416 Serine/threonine-protein kinase B-raf Homo sapiens 5100 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362247&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16419294 136966309 CHEMBL1939416 ZINC09422468 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713302 Nc1nc(Nc2cccc(F)c2)c2[nH]cnc2n1 InChI=1S/C11H9FN6/c12-6-2-1-3-7(4-6)16-10-8-9(15-5-14-8)17-11(13)18-10/h1-5H,(H4,13,14,15,16,17,18) SSBDEGSAVYKWMG-UHFFFAOYSA-N 50362248 CHEMBL1939417 Serine/threonine-protein kinase B-raf Homo sapiens 4800 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362248&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 14091123 136966310 CHEMBL1939417 ZINC09575540 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713303 Nc1nc(Nc2ccc(F)c(Cl)c2)c2[nH]cnc2n1 InChI=1S/C11H8ClFN6/c12-6-3-5(1-2-7(6)13)17-10-8-9(16-4-15-8)18-11(14)19-10/h1-4H,(H4,14,15,16,17,18,19) WZARUZRRIMOQSV-UHFFFAOYSA-N 50362249 CHEMBL1939418 Serine/threonine-protein kinase B-raf Homo sapiens 3200 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362249&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16422721 136966311 CHEMBL1939418 ZINC09575840 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713304 COc1cc(Nc2nc(N)nc3nc[nH]c23)cc(OC)c1OC InChI=1S/C14H16N6O3/c1-21-8-4-7(5-9(22-2)11(8)23-3)18-13-10-12(17-6-16-10)19-14(15)20-13/h4-6H,1-3H3,(H4,15,16,17,18,19,20) YYGKNHXJSASKNE-UHFFFAOYSA-N 50362250 CHEMBL1939419 Serine/threonine-protein kinase B-raf Homo sapiens 4100 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362250&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16425694 136966312 CHEMBL1939419 ZINC09423859 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713305 Nc1nc(Nc2ccc(Cl)c(Cl)c2)c2[nH]cnc2n1 InChI=1S/C11H8Cl2N6/c12-6-2-1-5(3-7(6)13)17-10-8-9(16-4-15-8)18-11(14)19-10/h1-4H,(H4,14,15,16,17,18,19) VWCBMKZYMUNGPZ-UHFFFAOYSA-N 50362251 CHEMBL1939420 Serine/threonine-protein kinase B-raf Homo sapiens 3600 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362251&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 14091118 136966313 CHEMBL1939420 ZINC08990395 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713306 COc1ccc(OC)c(Nc2nc(N)nc3nc[nH]c23)c1 InChI=1S/C13H14N6O2/c1-20-7-3-4-9(21-2)8(5-7)17-12-10-11(16-6-15-10)18-13(14)19-12/h3-6H,1-2H3,(H4,14,15,16,17,18,19) KJHDASWFKRBDMI-UHFFFAOYSA-N 50334272 CHEMBL1642669::N6-(2,5-dimethoxyphenyl)-9H-purine-2,6-diamine Serine/threonine-protein kinase B-raf Homo sapiens 430 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334272&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16422835 125084374 CHEMBL1642669 ZINC08992982 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713307 Nc1nc(Nc2cccc(Cl)c2)c2[nH]cnc2n1 InChI=1S/C11H9ClN6/c12-6-2-1-3-7(4-6)16-10-8-9(15-5-14-8)17-11(13)18-10/h1-5H,(H4,13,14,15,16,17,18) ISRYURDNPNYEFT-UHFFFAOYSA-N 50362252 CHEMBL1939421 Serine/threonine-protein kinase B-raf Homo sapiens 3000 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362252&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 14091117 136966314 CHEMBL1939421 ZINC09048818 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713308 Nc1nc(Nc2cccc(c2)C(F)(F)F)c2[nH]cnc2n1 InChI=1S/C12H9F3N6/c13-12(14,15)6-2-1-3-7(4-6)19-10-8-9(18-5-17-8)20-11(16)21-10/h1-5H,(H4,16,17,18,19,20,21) AHMKXMQGWWYHEN-UHFFFAOYSA-N 50362253 CHEMBL1939422 Serine/threonine-protein kinase B-raf Homo sapiens 1700 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362253&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16423982 136966315 CHEMBL1939422 ZINC08993206 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713309 C1COc2cc(Nc3nc(Nc4ccc5OCCOc5c4)c4[nH]cnc4n3)ccc2O1 InChI=1S/C21H18N6O4/c1-3-14-16(30-7-5-28-14)9-12(1)24-20-18-19(23-11-22-18)26-21(27-20)25-13-2-4-15-17(10-13)31-8-6-29-15/h1-4,9-11H,5-8H2,(H3,22,23,24,25,26,27) WAWYOKYUWRZFQH-UHFFFAOYSA-N 50362254 CHEMBL1939423 Serine/threonine-protein kinase B-raf Homo sapiens 5200 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362254&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16417732 136966316 CHEMBL1939423 ZINC08993258 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713310 COc1cc(Nc2nc(N)nc3nc[nH]c23)cc(OC)c1 InChI=1S/C13H14N6O2/c1-20-8-3-7(4-9(5-8)21-2)17-12-10-11(16-6-15-10)18-13(14)19-12/h3-6H,1-2H3,(H4,14,15,16,17,18,19) OFOQXZGRMZMUIM-UHFFFAOYSA-N 50362255 CHEMBL1939424 Serine/threonine-protein kinase B-raf Homo sapiens 3100 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362255&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16418315 136966317 CHEMBL1939424 ZINC08993691 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713311 Nc1nc(Nc2ccccc2O)c2[nH]cnc2n1 InChI=1S/C11H10N6O/c12-11-16-9-8(13-5-14-9)10(17-11)15-6-3-1-2-4-7(6)18/h1-5,18H,(H4,12,13,14,15,16,17) CYUJSASJOIJARY-UHFFFAOYSA-N 50362256 CHEMBL1939425 Serine/threonine-protein kinase B-raf Homo sapiens 2000 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362256&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 39353072 136966318 CHEMBL1939425 ZINC32105333 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50713312 CC(=O)Nc1ccc(Nc2ncnc3nc[nH]c23)cc1 InChI=1S/C13H12N6O/c1-8(20)18-9-2-4-10(5-3-9)19-13-11-12(15-6-14-11)16-7-17-13/h2-7H,1H3,(H,18,20)(H2,14,15,16,17,19) YGAFSGBWQFHVRW-UHFFFAOYSA-N 50362257 CHEMBL1939426 Serine/threonine-protein kinase B-raf Homo sapiens 790 ChEMBL 10.1016/j.bmcl.2011.11.124 10.7270/Q2FQ9X3T 22196123 Park, H; Jeong, Y; Hong, S Sejong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362257&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 39314085 136966319 CHEMBL1939426 ZINC32074030 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50715803 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1 InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32) FNHKPVJBJVTLMP-UHFFFAOYSA-N 50363397 CHEMBL1946170::REGORAFENIB::US10183928, Regorafenib::US10202365, Compound Regorafenib::US10227329, Compound Regorafenib::US10464902, Regorafenib::US10584114, Compound Regorafenib::US10774070, Compound Regorafenib::US11279688, Compound Regorafenib Serine/threonine-protein kinase B-raf Homo sapiens 28 ChEMBL 10.1016/j.bmcl.2011.11.060 10.7270/Q2SQ90VM 22222036 Zambon, A; Niculescu-Duvaz, I; Niculescu-Duvaz, D; Marais, R; Springer, CJ The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363397&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11167602 136967459 68647 CHEMBL1946170 DB08896 ZINC06745272 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50715804 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2ccc(Oc3ccnc(c3)-c3c[nH]c(n3)C(F)(F)F)cc12 InChI=1S/C24H16F6N6O/c1-36-20-11-15(37-16-8-9-31-18(10-16)19-12-32-21(34-19)24(28,29)30)6-7-17(20)35-22(36)33-14-4-2-13(3-5-14)23(25,26)27/h2-12H,1H3,(H,32,34)(H,33,35) HRCJMYWMDPFSHS-UHFFFAOYSA-N 50363398 CHEMBL1946171 Serine/threonine-protein kinase B-raf Homo sapiens 3 ChEMBL 10.1016/j.bmcl.2011.11.060 10.7270/Q2SQ90VM 22222036 Zambon, A; Niculescu-Duvaz, I; Niculescu-Duvaz, D; Marais, R; Springer, CJ The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363398&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57399335 136967460 CHEMBL1946171 ZINC73200190 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50715807 CN(C)CCOc1ccc(cc1)-c1nc(c([nH]1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1 InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,24H,6,10,15-16H2,1-2H3,(H,29,30) ZLWRKMXLUCZVAR-UHFFFAOYSA-N 25391 CHEMBL200622::SB-590885::SB590885::[2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)-1H-imidazol-2-yl}phenoxy)ethyl]dimethylamine Serine/threonine-protein kinase B-raf Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2011.11.060 10.7270/Q2SQ90VM 22222036 Zambon, A; Niculescu-Duvaz, I; Niculescu-Duvaz, D; Marais, R; Springer, CJ The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25391&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2FB8 91369525 56374530 CHEMBL200622 ZINC89224159 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50715808 CN(C)CCOc1ccc(cc1)-c1nc(c([nH]1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1 InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,24H,6,10,15-16H2,1-2H3,(H,29,30) ZLWRKMXLUCZVAR-UHFFFAOYSA-N 25391 CHEMBL200622::SB-590885::SB590885::[2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)-1H-imidazol-2-yl}phenoxy)ethyl]dimethylamine Serine/threonine-protein kinase B-raf Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2011.11.060 10.7270/Q2SQ90VM 22222036 Zambon, A; Niculescu-Duvaz, I; Niculescu-Duvaz, D; Marais, R; Springer, CJ The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25391&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2FB8 91369525 56374530 CHEMBL200622 ZINC89224159 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50715809 CN(C)CCOc1ccc(cc1)-c1nc(c([nH]1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1 InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,24H,6,10,15-16H2,1-2H3,(H,29,30) ZLWRKMXLUCZVAR-UHFFFAOYSA-N 25391 CHEMBL200622::SB-590885::SB590885::[2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)-1H-imidazol-2-yl}phenoxy)ethyl]dimethylamine Serine/threonine-protein kinase B-raf Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2011.11.060 10.7270/Q2SQ90VM 22222036 Zambon, A; Niculescu-Duvaz, I; Niculescu-Duvaz, D; Marais, R; Springer, CJ The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25391&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2FB8 91369525 56374530 CHEMBL200622 ZINC89224159 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50715810 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) YZDJQTHVDDOVHR-UHFFFAOYSA-N 25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720 Serine/threonine-protein kinase B-raf Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2011.11.060 10.7270/Q2SQ90VM 22222036 Zambon, A; Niculescu-Duvaz, I; Niculescu-Duvaz, D; Marais, R; Springer, CJ The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25617&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 324 3C4C,4WO5 24180719 56412907 DB06999 5703 ZINC39059267 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835086 O=NCc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H16N4O/c26-23-14-15-6-8-16(9-7-15)19-20(17-10-12-22-13-11-17)25-21(24-19)18-4-2-1-3-5-18/h1-13H,14H2,(H,24,25) GMDLYFPQUQPBDK-UHFFFAOYSA-N 50176317 4-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)benzaldehyde oxime::CHEMBL200783 Serine/threonine-protein kinase B-raf Homo sapiens 5 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176317&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91936375 104061985 CHEMBL200783 ZINC28564088 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835087 CN(C)CCOc1ccc(cc1)-c1nc(c([nH]1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1 InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,24H,6,10,15-16H2,1-2H3,(H,29,30) ZLWRKMXLUCZVAR-UHFFFAOYSA-N 25391 CHEMBL200622::SB-590885::SB590885::[2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)-1H-imidazol-2-yl}phenoxy)ethyl]dimethylamine Serine/threonine-protein kinase B-raf Homo sapiens 0.3 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25391&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2FB8 91369525 56374530 CHEMBL200622 ZINC89224159 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835088 Clc1cc(ccc1CN=O)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H15ClN4O/c22-18-12-16(6-7-17(18)13-24-27)20-19(14-8-10-23-11-9-14)25-21(26-20)15-4-2-1-3-5-15/h1-12H,13H2,(H,25,26) GRSIVPXYFIBMQQ-UHFFFAOYSA-N 50176319 2-chloro-4-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)benzaldehyde oxime::CHEMBL200412 Serine/threonine-protein kinase B-raf Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176319&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91936376 104061987 CHEMBL200412 ZINC28564264 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835089 CC(C)(CNS(C)(=O)=O)c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1 InChI=1S/C19H21ClN4O3S/c1-19(2,11-22-28(3,26)27)18-23-16(12-6-8-21-9-7-12)17(24-18)13-4-5-14(20)15(25)10-13/h4-10,22,25H,11H2,1-3H3,(H,23,24) CMKGLLDJHXJPIV-UHFFFAOYSA-N 50176320 CHEMBL381447::N-(2-(4-(4-chloro-3-hydroxyphenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)-2-methylpropyl)methanesulfonamide Serine/threonine-protein kinase B-raf Homo sapiens 10 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176320&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 21023795 104061988 CHEMBL381447 ZINC28563694 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835090 CC(C)(C)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C18H18FN3/c1-18(2,3)17-21-15(12-4-6-14(19)7-5-12)16(22-17)13-8-10-20-11-9-13/h4-11H,1-3H3,(H,21,22) RKTINGRJURYERF-UHFFFAOYSA-N 50176322 4-(2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyridine::CHEMBL371694 Serine/threonine-protein kinase B-raf Homo sapiens 900 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176322&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11737996 104061990 CHEMBL371694 ZINC08536321 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835091 Oc1cccc(c1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C20H15N3O/c24-17-8-4-7-16(13-17)19-18(14-9-11-21-12-10-14)22-20(23-19)15-5-2-1-3-6-15/h1-13,24H,(H,22,23) KPDQHNUZQHJLSJ-UHFFFAOYSA-N 50077961 3-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-phenol::3-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol::CHEMBL304624 Serine/threonine-protein kinase B-raf Homo sapiens 8 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077961&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2RN 4O7E 10638921 103970649 CHEMBL304624 ZINC08536641 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835092 Nc1nccc(n1)-c1nc([nH]c1-c1ccc(Cl)c(O)c1)-c1ccccc1 InChI=1S/C19H14ClN5O/c20-13-7-6-12(10-15(13)26)16-17(14-8-9-22-19(21)23-14)25-18(24-16)11-4-2-1-3-5-11/h1-10,26H,(H,24,25)(H2,21,22,23) OKHHFJVOMXBGTO-UHFFFAOYSA-N 50176321 5-(5-(2-aminopyrimidin-4-yl)-2-phenyl-1H-imidazol-4-yl)-2-chlorophenol::CHEMBL200258 Serine/threonine-protein kinase B-raf Homo sapiens 5.7 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176321&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406594 104061989 CHEMBL200258 ZINC28564065 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835093 CC(C)(CNC(=O)Nc1ccc(Cl)cc1)c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1 InChI=1S/C25H23Cl2N5O2/c1-25(2,14-29-24(34)30-18-6-4-17(26)5-7-18)23-31-21(15-9-11-28-12-10-15)22(32-23)16-3-8-19(27)20(33)13-16/h3-13,33H,14H2,1-2H3,(H,31,32)(H2,29,30,34) PQMASEVATAUGTO-UHFFFAOYSA-N 50176323 1-(2-(4-(4-chloro-3-hydroxyphenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)-2-methylpropyl)-3-(4-chlorophenyl)urea::CHEMBL200863 Serine/threonine-protein kinase B-raf Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176323&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 22185489 104061991 CHEMBL200863 ZINC28563122 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835094 Oc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C20H15N3O/c24-17-8-6-14(7-9-17)18-19(15-10-12-21-13-11-15)23-20(22-18)16-4-2-1-3-5-16/h1-13,24H,(H,22,23) PAXXIJHKIXSMOM-UHFFFAOYSA-N 50077976 4-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-phenol::4-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol::CHEMBL68215 Serine/threonine-protein kinase B-raf Homo sapiens 316 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077976&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10757558 103970663 CHEMBL68215 ZINC13798191 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835095 Oc1cc(ccc1Cl)-c1[nH]c(nc1-c1ccncc1)-c1cccnc1 InChI=1S/C19H13ClN4O/c20-15-4-3-13(10-16(15)25)18-17(12-5-8-21-9-6-12)23-19(24-18)14-2-1-7-22-11-14/h1-11,25H,(H,23,24) AMZKSFNYIWXGDY-UHFFFAOYSA-N 50176324 2-chloro-5-(2-(pyridin-3-yl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol::CHEMBL381250 Serine/threonine-protein kinase B-raf Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176324&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406460 104061992 CHEMBL381250 ZINC28563509 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835096 Oc1cc(ccc1Cl)-c1[nH]cnc1-c1ccncc1 InChI=1S/C14H10ClN3O/c15-11-2-1-10(7-12(11)19)14-13(17-8-18-14)9-3-5-16-6-4-9/h1-8,19H,(H,17,18) ZMJGBZMGACHTLA-UHFFFAOYSA-N 50176325 2-chloro-5-(5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol::CHEMBL200118 Serine/threonine-protein kinase B-raf Homo sapiens 33 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176325&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 22256705 104061993 CHEMBL200118 ZINC28566569 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835097 Oc1cc(ccc1Cl)-c1[nH]c(nc1-c1ccncn1)-c1ccccc1 InChI=1S/C19H13ClN4O/c20-14-7-6-13(10-16(14)25)17-18(15-8-9-21-11-22-15)24-19(23-17)12-4-2-1-3-5-12/h1-11,25H,(H,23,24) NPGMXUVYVDMIQF-UHFFFAOYSA-N 50176326 2-chloro-5-(2-phenyl-5-(pyrimidin-4-yl)-1H-imidazol-4-yl)phenol::CHEMBL370353 Serine/threonine-protein kinase B-raf Homo sapiens 14 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176326&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406418 104061994 CHEMBL370353 ZINC28563862 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835098 Oc1cc(ccc1Cl)-c1[nH]c(nc1-c1cccnc1)-c1ccccc1 InChI=1S/C20H14ClN3O/c21-16-9-8-14(11-17(16)25)18-19(15-7-4-10-22-12-15)24-20(23-18)13-5-2-1-3-6-13/h1-12,25H,(H,23,24) BQWQZFAQECHLIW-UHFFFAOYSA-N 50176327 2-chloro-5-(2-phenyl-5-(pyridin-3-yl)-1H-imidazol-4-yl)phenol::CHEMBL200156 Serine/threonine-protein kinase B-raf Homo sapiens >200 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176327&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406417 104061995 CHEMBL200156 ZINC28563860 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835099 Oc1cc(ccc1Cl)-c1[nH]c(nc1-c1ccncc1)-c1ccco1 InChI=1S/C18H12ClN3O2/c19-13-4-3-12(10-14(13)23)17-16(11-5-7-20-8-6-11)21-18(22-17)15-2-1-9-24-15/h1-10,23H,(H,21,22) AIHXMCSSAUGRNS-UHFFFAOYSA-N 50176329 2-chloro-5-(2-(furan-2-yl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol::CHEMBL371952 Serine/threonine-protein kinase B-raf Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176329&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406429 104061997 CHEMBL371952 ZINC28566567 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835100 OCc1cccc(c1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H17N3O/c25-14-15-5-4-8-18(13-15)20-19(16-9-11-22-12-10-16)23-21(24-20)17-6-2-1-3-7-17/h1-13,25H,14H2,(H,23,24) VSUBTSHXVQUZCL-UHFFFAOYSA-N 50176328 (3-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenyl)methanol::CHEMBL200259 Serine/threonine-protein kinase B-raf Homo sapiens 1585 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176328&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406595 104061996 CHEMBL200259 ZINC28564066 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835101 OCc1ccc(cc1O)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H17N3O2/c25-13-17-7-6-16(12-18(17)26)20-19(14-8-10-22-11-9-14)23-21(24-20)15-4-2-1-3-5-15/h1-12,25-26H,13H2,(H,23,24) XSPXTJQCESOGST-UHFFFAOYSA-N 50176330 2-(hydroxymethyl)-5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol::CHEMBL427196 Serine/threonine-protein kinase B-raf Homo sapiens 22 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176330&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406596 104061998 CHEMBL427196 ZINC28564067 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835102 Oc1cc(ccc1Cl)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24) WXJLXRNWMLWVFB-UHFFFAOYSA-N 26041 2-chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol::2-chloro-5-[2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl]phenol::CHEMBL373011::L-779,450::L-779450 Serine/threonine-protein kinase B-raf Homo sapiens 2.4 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26041&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9950176 56464478 CHEMBL373011 ZINC28563889 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835103 O=NC1CCCc2cc(ccc12)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C24H20N4O/c29-28-21-8-4-7-18-15-19(9-10-20(18)21)23-22(16-11-13-25-14-12-16)26-24(27-23)17-5-2-1-3-6-17/h1-3,5-6,9-15,21H,4,7-8H2,(H,26,27) WBHRHMNVVRGJSX-UHFFFAOYSA-N 50176331 6-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)-3,4-dihydronaphthalen-1(2H)-one oxime::CHEMBL200164 Serine/threonine-protein kinase B-raf Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176331&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91936377 104061999 CHEMBL200164 ZINC28563789 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835104 NCc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1 InChI=1S/C21H17ClN4O/c22-17-6-5-16(11-18(17)27)20-19(14-7-9-24-10-8-14)25-21(26-20)15-3-1-13(12-23)2-4-15/h1-11,27H,12,23H2,(H,25,26) UOHHVCYLYIQXFG-UHFFFAOYSA-N 26040 5-{2-[4-(aminomethyl)phenyl]-5-(pyridin-4-yl)-1H-imidazol-4-yl}-2-chlorophenol::CHEMBL200320::Rhodamine green labeled 5-{2-[4-(aminomethyl)phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl}-2-chlorophenol::Rhodamine green labeled ligand Serine/threonine-protein kinase B-raf Homo sapiens 5.3 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26040&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 22185379 56464477 CHEMBL200320 ZINC28563646 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835105 Oc1cc(ccc1Cl)-c1[nH]c(nc1-c1ccnnc1)-c1ccccc1 InChI=1S/C19H13ClN4O/c20-15-7-6-13(10-16(15)25)17-18(14-8-9-21-22-11-14)24-19(23-17)12-4-2-1-3-5-12/h1-11,25H,(H,23,24) HRCICYDCQKXUPS-UHFFFAOYSA-N 50176333 2-chloro-5-(2-phenyl-5-(pyridazin-4-yl)-1H-imidazol-4-yl)phenol::CHEMBL381421 Serine/threonine-protein kinase B-raf Homo sapiens 87 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176333&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406593 104062001 CHEMBL381421 ZINC28564063 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835106 CC(C)(CN)c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1 InChI=1S/C18H19ClN4O/c1-18(2,10-20)17-22-15(11-5-7-21-8-6-11)16(23-17)12-3-4-13(19)14(24)9-12/h3-9,24H,10,20H2,1-2H3,(H,22,23) YRHGMGAVJILIGS-UHFFFAOYSA-N 50176334 5-(2-(1-amino-2-methylpropan-2-yl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2-chlorophenol::CHEMBL200889 Serine/threonine-protein kinase B-raf Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176334&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 22185475 104062002 CHEMBL200889 ZINC28563455 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835107 Oc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C20H15N3O/c24-17-8-6-14(7-9-17)18-19(15-10-12-21-13-11-15)23-20(22-18)16-4-2-1-3-5-16/h1-13,24H,(H,22,23) PAXXIJHKIXSMOM-UHFFFAOYSA-N 50077976 4-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-phenol::4-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol::CHEMBL68215 Serine/threonine-protein kinase B-raf Homo sapiens 339 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077976&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10757558 103970663 CHEMBL68215 ZINC13798191 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835108 OC1CCc2cc(ccc12)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C23H19N3O/c27-20-9-7-17-14-18(6-8-19(17)20)22-21(15-10-12-24-13-11-15)25-23(26-22)16-4-2-1-3-5-16/h1-6,8,10-14,20,27H,7,9H2,(H,25,26) SRJZHPJMEZGLLR-UHFFFAOYSA-N 50176336 5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-ol::CHEMBL200782 Serine/threonine-protein kinase B-raf Homo sapiens >200 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176336&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406583 104062004 CHEMBL200782 ZINC28564013 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835109 CC(C)(CNC(=O)Nc1ccc(Cl)cc1)c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1 InChI=1S/C25H23Cl2N5O2/c1-25(2,14-29-24(34)30-18-6-4-17(26)5-7-18)23-31-21(15-9-11-28-12-10-15)22(32-23)16-3-8-19(27)20(33)13-16/h3-13,33H,14H2,1-2H3,(H,31,32)(H2,29,30,34) PQMASEVATAUGTO-UHFFFAOYSA-N 50176323 1-(2-(4-(4-chloro-3-hydroxyphenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)-2-methylpropyl)-3-(4-chlorophenyl)urea::CHEMBL200863 Serine/threonine-protein kinase B-raf Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176323&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 22185489 104061991 CHEMBL200863 ZINC28563122 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835110 CC(C)(C)c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1 InChI=1S/C18H18ClN3O/c1-18(2,3)17-21-15(11-6-8-20-9-7-11)16(22-17)12-4-5-13(19)14(23)10-12/h4-10,23H,1-3H3,(H,21,22) GVBAIQGUTPWWPT-UHFFFAOYSA-N 50176335 5-(2-tert-butyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2-chlorophenol::CHEMBL200172 Serine/threonine-protein kinase B-raf Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176335&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406537 104062003 CHEMBL200172 ZINC28563769 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835111 O=NC1CCc2cc(ccc12)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C23H18N4O/c28-27-20-9-7-17-14-18(6-8-19(17)20)22-21(15-10-12-24-13-11-15)25-23(26-22)16-4-2-1-3-5-16/h1-6,8,10-14,20H,7,9H2,(H,25,26) XMKOUZLRNYKHIU-UHFFFAOYSA-N 50176337 5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydroinden-1-one oxime::CHEMBL372543 Serine/threonine-protein kinase B-raf Homo sapiens 1.3 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176337&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 90818931 104062005 CHEMBL372543 ZINC28563787 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835112 ONC(=N)c1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H17N5O/c22-20(26-27)16-8-6-14(7-9-16)18-19(15-10-12-23-13-11-15)25-21(24-18)17-4-2-1-3-5-17/h1-13,27H,(H2,22,26)(H,24,25) RRQDQBVVMFQWPC-UHFFFAOYSA-N 50176338 CHEMBL200431::N'-hydroxy-4-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)benzamidine Serine/threonine-protein kinase B-raf Homo sapiens 53 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176338&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406578 104062006 CHEMBL200431 ZINC28563997 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835113 Oc1cc(ccc1Cl)-c1[nH]cnc1-c1ccncc1 InChI=1S/C14H10ClN3O/c15-11-2-1-10(7-12(11)19)14-13(17-8-18-14)9-3-5-16-6-4-9/h1-8,19H,(H,17,18) ZMJGBZMGACHTLA-UHFFFAOYSA-N 50176325 2-chloro-5-(5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol::CHEMBL200118 Serine/threonine-protein kinase B-raf Homo sapiens 39 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176325&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 22256705 104061993 CHEMBL200118 ZINC28566569 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835114 Oc1cc(ccc1Cl)-c1[nH]c(nc1-c1ccncc1)-c1ccco1 InChI=1S/C18H12ClN3O2/c19-13-4-3-12(10-14(13)23)17-16(11-5-7-20-8-6-11)21-18(22-17)15-2-1-9-24-15/h1-10,23H,(H,21,22) AIHXMCSSAUGRNS-UHFFFAOYSA-N 50176329 2-chloro-5-(2-(furan-2-yl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol::CHEMBL371952 Serine/threonine-protein kinase B-raf Homo sapiens 4.2 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176329&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406429 104061997 CHEMBL371952 ZINC28566567 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835115 Oc1cc(ccc1Cl)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24) WXJLXRNWMLWVFB-UHFFFAOYSA-N 26041 2-chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol::2-chloro-5-[2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl]phenol::CHEMBL373011::L-779,450::L-779450 Serine/threonine-protein kinase B-raf Homo sapiens 10 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26041&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9950176 56464478 CHEMBL373011 ZINC28563889 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835116 Oc1cc(ccc1CN=O)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H16N4O2/c26-18-12-16(6-7-17(18)13-23-27)20-19(14-8-10-22-11-9-14)24-21(25-20)15-4-2-1-3-5-15/h1-12,26H,13H2,(H,24,25) XPIHYULIOOYXRY-UHFFFAOYSA-N 50176340 2-hydroxy-4-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)benzaldehyde oxime::CHEMBL200942 Serine/threonine-protein kinase B-raf Homo sapiens 27 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176340&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91936379 104062008 CHEMBL200942 ZINC28564106 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835117 CN(C)CCCNC(=O)c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1 InChI=1S/C20H22ClN5O2/c1-26(2)11-3-8-23-20(28)19-24-17(13-6-9-22-10-7-13)18(25-19)14-4-5-15(21)16(27)12-14/h4-7,9-10,12,27H,3,8,11H2,1-2H3,(H,23,28)(H,24,25) JKGOUELCADFHSY-UHFFFAOYSA-N 50176341 4-(4-chloro-3-hydroxyphenyl)-N-(3-(dimethylamino)propyl)-5-(pyridin-4-yl)-1H-imidazole-2-carboxamide::CHEMBL426476 Serine/threonine-protein kinase B-raf Homo sapiens 24 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176341&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10222594 104062009 CHEMBL426476 ZINC28563473 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835118 CC(C)(CN)c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1 InChI=1S/C18H19ClN4O/c1-18(2,10-20)17-22-15(11-5-7-21-8-6-11)16(23-17)12-3-4-13(19)14(24)9-12/h3-9,24H,10,20H2,1-2H3,(H,22,23) YRHGMGAVJILIGS-UHFFFAOYSA-N 50176334 5-(2-(1-amino-2-methylpropan-2-yl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2-chlorophenol::CHEMBL200889 Serine/threonine-protein kinase B-raf Homo sapiens 4.8 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176334&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 22185475 104062002 CHEMBL200889 ZINC28563455 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835119 COc1cccc(c1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H17N3O/c1-25-18-9-5-8-17(14-18)20-19(15-10-12-22-13-11-15)23-21(24-20)16-6-3-2-4-7-16/h2-14H,1H3,(H,23,24) CYCXCKOESWCLST-UHFFFAOYSA-N 50077967 4-(4-(3-methoxyphenyl)-2-phenyl-1H-imidazol-5-yl)pyridine::4-[5-(3-Methoxy-phenyl)-2-phenyl-3H-imidazol-4-yl]-pyridine::CHEMBL305023 Serine/threonine-protein kinase B-raf Homo sapiens >196 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077967&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10639924 103970655 CHEMBL305023 ZINC08536360 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835120 CC(C)(CNS(C)(=O)=O)c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1 InChI=1S/C19H21ClN4O3S/c1-19(2,11-22-28(3,26)27)18-23-16(12-6-8-21-9-7-12)17(24-18)13-4-5-14(20)15(25)10-13/h4-10,22,25H,11H2,1-3H3,(H,23,24) CMKGLLDJHXJPIV-UHFFFAOYSA-N 50176320 CHEMBL381447::N-(2-(4-(4-chloro-3-hydroxyphenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)-2-methylpropyl)methanesulfonamide Serine/threonine-protein kinase B-raf Homo sapiens 14 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176320&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 21023795 104061988 CHEMBL381447 ZINC28563694 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835121 CC(N=O)c1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C22H18N4O/c1-15(26-27)16-7-9-17(10-8-16)20-21(18-11-13-23-14-12-18)25-22(24-20)19-5-3-2-4-6-19/h2-15H,1H3,(H,24,25) WOTWVUVZQBUPBN-UHFFFAOYSA-N 50176339 1-(4-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenyl)ethanone oxime::CHEMBL200637 Serine/threonine-protein kinase B-raf Homo sapiens 11 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176339&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 91936378 104062007 CHEMBL200637 ZINC28564266 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835122 OCc1cccc(c1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H17N3O/c25-14-15-5-4-8-18(13-15)20-19(16-9-11-22-12-10-16)23-21(24-20)17-6-2-1-3-7-17/h1-13,25H,14H2,(H,23,24) VSUBTSHXVQUZCL-UHFFFAOYSA-N 50176328 (3-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenyl)methanol::CHEMBL200259 Serine/threonine-protein kinase B-raf Homo sapiens >196 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176328&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406595 104061996 CHEMBL200259 ZINC28564066 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835123 Oc1cc(ccc1Cl)-c1[nH]c(nc1-c1ccccc1)-c1ccccc1 InChI=1S/C21H15ClN2O/c22-17-12-11-16(13-18(17)25)20-19(14-7-3-1-4-8-14)23-21(24-20)15-9-5-2-6-10-15/h1-13,25H,(H,23,24) NXUJOLZEKJPLBA-UHFFFAOYSA-N 50176342 2-chloro-5-(2,5-diphenyl-1H-imidazol-4-yl)phenol::CHEMBL200861 Serine/threonine-protein kinase B-raf Homo sapiens >200 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176342&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406414 104062010 CHEMBL200861 ZINC28563581 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835124 NCc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1 InChI=1S/C21H17ClN4O/c22-17-6-5-16(11-18(17)27)20-19(14-7-9-24-10-8-14)25-21(26-20)15-3-1-13(12-23)2-4-15/h1-11,27H,12,23H2,(H,25,26) UOHHVCYLYIQXFG-UHFFFAOYSA-N 26040 5-{2-[4-(aminomethyl)phenyl]-5-(pyridin-4-yl)-1H-imidazol-4-yl}-2-chlorophenol::CHEMBL200320::Rhodamine green labeled 5-{2-[4-(aminomethyl)phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl}-2-chlorophenol::Rhodamine green labeled ligand Serine/threonine-protein kinase B-raf Homo sapiens 8 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26040&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 22185379 56464477 CHEMBL200320 ZINC28563646 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835125 CC(C)(C)c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1 InChI=1S/C18H18ClN3O/c1-18(2,3)17-21-15(11-6-8-20-9-7-11)16(22-17)12-4-5-13(19)14(23)10-12/h4-10,23H,1-3H3,(H,21,22) GVBAIQGUTPWWPT-UHFFFAOYSA-N 50176335 5-(2-tert-butyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2-chlorophenol::CHEMBL200172 Serine/threonine-protein kinase B-raf Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176335&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406537 104062003 CHEMBL200172 ZINC28563769 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835126 CN(C)CCCNC(=O)c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1 InChI=1S/C20H22ClN5O2/c1-26(2)11-3-8-23-20(28)19-24-17(13-6-9-22-10-7-13)18(25-19)14-4-5-15(21)16(27)12-14/h4-7,9-10,12,27H,3,8,11H2,1-2H3,(H,23,28)(H,24,25) JKGOUELCADFHSY-UHFFFAOYSA-N 50176341 4-(4-chloro-3-hydroxyphenyl)-N-(3-(dimethylamino)propyl)-5-(pyridin-4-yl)-1H-imidazole-2-carboxamide::CHEMBL426476 Serine/threonine-protein kinase B-raf Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176341&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10222594 104062009 CHEMBL426476 ZINC28563473 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835127 OCc1ccc(cc1Cl)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H16ClN3O/c22-18-12-16(6-7-17(18)13-26)20-19(14-8-10-23-11-9-14)24-21(25-20)15-4-2-1-3-5-15/h1-12,26H,13H2,(H,24,25) UHESUBCPHYMNSP-UHFFFAOYSA-N 50176344 (2-chloro-4-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenyl)methanol::CHEMBL435744 Serine/threonine-protein kinase B-raf Homo sapiens 132 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176344&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406599 104062012 CHEMBL435744 ZINC28564240 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50835128 OCc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H17N3O/c25-14-15-6-8-16(9-7-15)19-20(17-10-12-22-13-11-17)24-21(23-19)18-4-2-1-3-5-18/h1-13,25H,14H2,(H,23,24) XZNBYPWHHNKCLM-UHFFFAOYSA-N 50176343 (4-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenyl)methanol::CHEMBL200226 Serine/threonine-protein kinase B-raf Homo sapiens 71 ChEMBL 10.1016/j.bmcl.2005.09.072 10.7270/Q2Z038Z9 16260133 Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176343&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44406517 104062011 CHEMBL200226 ZINC28563954 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870890 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 200 ChEMBL 10.1073/pnas.0707498104 10.7270/Q24X58QS 18077425 McDermott, U; Sharma, SV; Dowell, L; Greninger, P; Montagut, C; Lamb, J; Archibald, H; Raudales, R; Tam, A; Lee, D; Rothenberg, SM; Supko, JG; Sordella, R; Ulkus, LE; Iafrate, AJ; Maheswaran, S; Njauw, CN; Tsao, H; Drew, L; Hanke, JH; Ma, XJ; Erlander, MG; Gray, NS; Haber, DA; Settleman, J Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873728 CCn1cc(c(n1)-c1cccc(NC(=S)Nc2ccccc2)c1)-c1ccnc2[nH]ccc12 InChI=1S/C25H22N6S/c1-2-31-16-22(20-11-13-26-24-21(20)12-14-27-24)23(30-31)17-7-6-10-19(15-17)29-25(32)28-18-8-4-3-5-9-18/h3-16H,2H2,1H3,(H,26,27)(H2,28,29,32) RCCVNXWUYFNXCF-UHFFFAOYSA-N 50272782 1-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)-3-phenylthiourea::CHEMBL524635 Serine/threonine-protein kinase B-raf Homo sapiens 331 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272782&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44587510 104117101 CHEMBL524635 ZINC40429442 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873729 CCn1cc(c(n1)-c1cccc(NC(=O)Nc2ccccc2)c1)-c1ccnc2[nH]c(cc12)C(O)=O InChI=1S/C26H22N6O3/c1-2-32-15-21(19-11-12-27-24-20(19)14-22(30-24)25(33)34)23(31-32)16-7-6-10-18(13-16)29-26(35)28-17-8-4-3-5-9-17/h3-15H,2H2,1H3,(H,27,30)(H,33,34)(H2,28,29,35) SZODMJYILAJCRL-UHFFFAOYSA-N 50377951 CHEMBL1964274 Serine/threonine-protein kinase B-raf Homo sapiens 45.7 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377951&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57394914 160857034 CHEMBL1964274 ZINC73296619 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873730 CCOC(=O)c1cc2c(ccnc2[nH]1)-c1cn(CC)nc1-c1cccc(NC(=O)Nc2ccccc2)c1 InChI=1S/C28H26N6O3/c1-3-34-17-23(21-13-14-29-26-22(21)16-24(32-26)27(35)37-4-2)25(33-34)18-9-8-12-20(15-18)31-28(36)30-19-10-6-5-7-11-19/h5-17H,3-4H2,1-2H3,(H,29,32)(H2,30,31,36) XSIYRNASQCOSNU-UHFFFAOYSA-N 50377952 CHEMBL1964273 Serine/threonine-protein kinase B-raf Homo sapiens 33.9 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377952&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57394913 160857035 CHEMBL1964273 ZINC73296132 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873731 CCn1cc(c(n1)-c1cccc(NC(=O)Nc2ccccc2)c1)-c1ccnc2[nH]cc(Br)c12 InChI=1S/C25H21BrN6O/c1-2-32-15-20(19-11-12-27-24-22(19)21(26)14-28-24)23(31-32)16-7-6-10-18(13-16)30-25(33)29-17-8-4-3-5-9-17/h3-15H,2H2,1H3,(H,27,28)(H2,29,30,33) RVEQFTVCNSMDSI-UHFFFAOYSA-N 50272894 1-(3-(4-(3-bromo-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-3-phenylurea::CHEMBL456351 Serine/threonine-protein kinase B-raf Homo sapiens 79.4 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272894&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44587584 104117194 CHEMBL456351 ZINC40848130 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873732 CCn1cc(c(n1)-c1cccc(NC(=O)Nc2cccc(OC)c2)c1)-c1ccnc2[nH]ccc12 InChI=1S/C26H24N6O2/c1-3-32-16-23(21-10-12-27-25-22(21)11-13-28-25)24(31-32)17-6-4-7-18(14-17)29-26(33)30-19-8-5-9-20(15-19)34-2/h4-16H,3H2,1-2H3,(H,27,28)(H2,29,30,33) IMXOZHDOGFUUPQ-UHFFFAOYSA-N 50272893 1-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)-3-(3-methoxyphenyl)urea::CHEMBL456350 Serine/threonine-protein kinase B-raf Homo sapiens 2.1 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272893&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44587583 104117193 CHEMBL456350 ZINC40848129 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873733 CCn1cc(c(n1)-c1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1)-c1ccnc2[nH]ccc12 InChI=1S/C26H20ClF3N6O/c1-2-36-14-20(18-8-10-31-24-19(18)9-11-32-24)23(35-36)15-4-3-5-16(12-15)33-25(37)34-17-6-7-22(27)21(13-17)26(28,29)30/h3-14H,2H2,1H3,(H,31,32)(H2,33,34,37) LQTOFIINEFIDNP-UHFFFAOYSA-N 50272892 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea::CHEMBL456983 Serine/threonine-protein kinase B-raf Homo sapiens 5.4 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272892&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44587582 104117192 CHEMBL456983 ZINC43171857 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873734 CCn1cc(c(n1)-c1cccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)c1)-c1ccnc2[nH]ccc12 InChI=1S/C26H20F4N6O/c1-2-36-14-20(18-8-10-31-24-19(18)9-11-32-24)23(35-36)15-4-3-5-17(12-15)33-25(37)34-22-13-16(26(28,29)30)6-7-21(22)27/h3-14H,2H2,1H3,(H,31,32)(H2,33,34,37) UXQKKNGDWVJRTL-UHFFFAOYSA-N 50272855 1-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea::CHEMBL526268 Serine/threonine-protein kinase B-raf Homo sapiens 3.9 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272855&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44587552 104117160 CHEMBL526268 ZINC40430985 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873735 CCn1cc(c(n1)-c1cccc(NC(=O)Nc2cccc(Cl)c2)c1)-c1ccnc2[nH]ccc12 InChI=1S/C25H21ClN6O/c1-2-32-15-22(20-9-11-27-24-21(20)10-12-28-24)23(31-32)16-5-3-7-18(13-16)29-25(33)30-19-8-4-6-17(26)14-19/h3-15H,2H2,1H3,(H,27,28)(H2,29,30,33) XWRQRFRLQKTFJA-UHFFFAOYSA-N 50272854 1-(3-chlorophenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea::CHEMBL497484 Serine/threonine-protein kinase B-raf Homo sapiens 10.5 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272854&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44587551 104117159 CHEMBL497484 ZINC40972783 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873736 CCn1cc(c(n1)-c1cccc(NC(=O)Nc2ccc(cc2)C(F)(F)F)c1)-c1ccnc2[nH]ccc12 InChI=1S/C26H21F3N6O/c1-2-35-15-22(20-10-12-30-24-21(20)11-13-31-24)23(34-35)16-4-3-5-19(14-16)33-25(36)32-18-8-6-17(7-9-18)26(27,28)29/h3-15H,2H2,1H3,(H,30,31)(H2,32,33,36) XMVDDSSINBJQNA-UHFFFAOYSA-N 50272853 1-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea::CHEMBL523411 Serine/threonine-protein kinase B-raf Homo sapiens 2.5 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272853&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24995525 104117158 CHEMBL523411 ZINC40430147 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873737 CCn1cc(c(n1)-c1cccc(NC(=O)Nc2c(F)cccc2F)c1)-c1ccnc2[nH]ccc12 InChI=1S/C25H20F2N6O/c1-2-33-14-19(17-9-11-28-24-18(17)10-12-29-24)22(32-33)15-5-3-6-16(13-15)30-25(34)31-23-20(26)7-4-8-21(23)27/h3-14H,2H2,1H3,(H,28,29)(H2,30,31,34) IZDTVEXCUPMSAM-UHFFFAOYSA-N 50272852 1-(2,6-difluorophenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea::CHEMBL496275 Serine/threonine-protein kinase B-raf Homo sapiens 25.7 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272852&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44587550 104117157 CHEMBL496275 ZINC40956796 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873738 CCn1cc(c(n1)-c1cccc(NC(=O)Nc2ccccc2Cl)c1)-c1ccnc2[nH]ccc12 InChI=1S/C25H21ClN6O/c1-2-32-15-20(18-10-12-27-24-19(18)11-13-28-24)23(31-32)16-6-5-7-17(14-16)29-25(33)30-22-9-4-3-8-21(22)26/h3-15H,2H2,1H3,(H,27,28)(H2,29,30,33) HNLAXQKKRHHHCK-UHFFFAOYSA-N 50272817 1-(2-chlorophenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea::CHEMBL525896 Serine/threonine-protein kinase B-raf Homo sapiens 5.3 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272817&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44587531 104117128 CHEMBL525896 ZINC40976504 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873739 CCn1cc(c(n1)-c1cccc(NC(=O)Nc2ccc(OCc3ccccc3)cc2)c1)-c1ccnc2[nH]ccc12 InChI=1S/C32H28N6O2/c1-2-38-20-29(27-15-17-33-31-28(27)16-18-34-31)30(37-38)23-9-6-10-25(19-23)36-32(39)35-24-11-13-26(14-12-24)40-21-22-7-4-3-5-8-22/h3-20H,2,21H2,1H3,(H,33,34)(H2,35,36,39) QNTVJRSWYJREKJ-UHFFFAOYSA-N 50272816 1-(4-(benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea::CHEMBL505187 Serine/threonine-protein kinase B-raf Homo sapiens 110 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272816&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44587530 104117127 CHEMBL505187 ZINC42834949 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873740 CCn1cc(c(n1)-c1cccc(NC(=O)NCc2ccccc2)c1)-c1ccnc2[nH]ccc12 InChI=1S/C26H24N6O/c1-2-32-17-23(21-11-13-27-25-22(21)12-14-28-25)24(31-32)19-9-6-10-20(15-19)30-26(33)29-16-18-7-4-3-5-8-18/h3-15,17H,2,16H2,1H3,(H,27,28)(H2,29,30,33) YPZBXHLQIIRGGT-UHFFFAOYSA-N 50272815 1-benzyl-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea::CHEMBL496265 Serine/threonine-protein kinase B-raf Homo sapiens 170 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272815&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44587529 104117126 CHEMBL496265 ZINC40955373 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873741 CCn1cc(c(n1)-c1cccc(NC(=O)NC2CCCCC2)c1)-c1ccnc2[nH]ccc12 InChI=1S/C25H28N6O/c1-2-31-16-22(20-11-13-26-24-21(20)12-14-27-24)23(30-31)17-7-6-10-19(15-17)29-25(32)28-18-8-4-3-5-9-18/h6-7,10-16,18H,2-5,8-9H2,1H3,(H,26,27)(H2,28,29,32) RPXJQPGZDGLGOH-UHFFFAOYSA-N 50272814 1-cyclohexyl-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea::CHEMBL522902 Serine/threonine-protein kinase B-raf Homo sapiens 41.7 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272814&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44587528 104117125 CHEMBL522902 ZINC40430794 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873742 CCn1cc(c(n1)-c1cccc(NC(=O)Nc2ccccc2)c1)-c1ccnc2[nH]ccc12 InChI=1S/C25H22N6O/c1-2-31-16-22(20-11-13-26-24-21(20)12-14-27-24)23(30-31)17-7-6-10-19(15-17)29-25(32)28-18-8-4-3-5-9-18/h3-16H,2H2,1H3,(H,26,27)(H2,28,29,32) BUTSSCBHZQMTEB-UHFFFAOYSA-N 50272783 1-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)-3-phenylurea::CHEMBL498307 Serine/threonine-protein kinase B-raf Homo sapiens 17.4 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272783&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 16678105 104117102 CHEMBL498307 ZINC40974688 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50873743 CCn1cc(c(n1)-c1cccc(NC(=O)Nc2ccc(cc2)C(F)(F)F)c1)-c1ccnc2[nH]ccc12 InChI=1S/C26H21F3N6O/c1-2-35-15-22(20-10-12-30-24-21(20)11-13-31-24)23(34-35)16-4-3-5-19(14-16)33-25(36)32-18-8-6-17(7-9-18)26(27,28)29/h3-15H,2H2,1H3,(H,30,31)(H2,32,33,36) XMVDDSSINBJQNA-UHFFFAOYSA-N 50272853 1-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea::CHEMBL523411 Serine/threonine-protein kinase B-raf Homo sapiens 63 ChEMBL 10.1016/j.bmcl.2008.07.019 10.7270/Q21N821S 18662874 Tang, J; Hamajima, T; Nakano, M; Sato, H; Dickerson, SH; Lackey, KE GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272853&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 24995525 104117158 CHEMBL523411 ZINC40430147 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870185 FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)-c2[nH]c(nc2-c2ccnc(NCCN3CCNC3=O)n2)C2CC2)ccc1Cl InChI=1S/C29H27ClF3N9O2/c30-21-7-6-19(15-20(21)29(31,32)33)38-27(43)37-18-3-1-2-17(14-18)23-24(41-25(40-23)16-4-5-16)22-8-9-34-26(39-22)35-10-12-42-13-11-36-28(42)44/h1-3,6-9,14-16H,4-5,10-13H2,(H,36,44)(H,40,41)(H,34,35,39)(H2,37,38,43) ZTZSKHGZPQXQKE-UHFFFAOYSA-N 50377758 CHEMBL256921 Serine/threonine-protein kinase B-raf Homo sapiens 66 ChEMBL 10.1016/j.bmcl.2008.04.002 10.7270/Q2DJ5GH8 18434146 Wolin, RL; Bembenek, SD; Wei, J; Crawford, S; Lundeen, K; Brunmark, A; Karlsson, L; Edwards, JP; Blevitt, JM Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377758&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25066845 160856841 CHEMBL256921 ZINC29042641 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870187 Clc1ccc(CS(=O)(=O)Nc2cccc(c2)-c2[nH]c(nc2-c2ccnc(NCCN3CCNC3=O)n2)C2CC2)cc1Cl InChI=1S/C28H28Cl2N8O3S/c29-21-7-4-17(14-22(21)30)16-42(40,41)37-20-3-1-2-19(15-20)24-25(36-26(35-24)18-5-6-18)23-8-9-31-27(34-23)32-10-12-38-13-11-33-28(38)39/h1-4,7-9,14-15,18,37H,5-6,10-13,16H2,(H,33,39)(H,35,36)(H,31,32,34) NTUPINFPCXIWMM-UHFFFAOYSA-N 50377759 CHEMBL255497 Serine/threonine-protein kinase B-raf Homo sapiens 343 ChEMBL 10.1016/j.bmcl.2008.04.002 10.7270/Q2DJ5GH8 18434146 Wolin, RL; Bembenek, SD; Wei, J; Crawford, S; Lundeen, K; Brunmark, A; Karlsson, L; Edwards, JP; Blevitt, JM Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377759&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44448333 160856842 CHEMBL255497 ZINC29042574 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870188 NC(=O)c1cccc(Nc2nccc(n2)-c2nc([nH]c2-c2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2)C2CC2)c1 InChI=1S/C31H24ClF3N8O2/c32-23-10-9-21(15-22(23)31(33,34)35)40-30(45)39-20-6-1-3-17(13-20)25-26(43-28(42-25)16-7-8-16)24-11-12-37-29(41-24)38-19-5-2-4-18(14-19)27(36)44/h1-6,9-16H,7-8H2,(H2,36,44)(H,42,43)(H,37,38,41)(H2,39,40,45) SJDILUBLGOUKNA-UHFFFAOYSA-N 50377760 CHEMBL255496 Serine/threonine-protein kinase B-raf Homo sapiens 35 ChEMBL 10.1016/j.bmcl.2008.04.002 10.7270/Q2DJ5GH8 18434146 Wolin, RL; Bembenek, SD; Wei, J; Crawford, S; Lundeen, K; Brunmark, A; Karlsson, L; Edwards, JP; Blevitt, JM Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377760&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44448332 160856843 CHEMBL255496 ZINC29042572 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870189 CNc1nccc(n1)-c1nc([nH]c1-c1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1)C1CC1 InChI=1S/C25H21ClF3N7O/c1-30-23-31-10-9-19(34-23)21-20(35-22(36-21)13-5-6-13)14-3-2-4-15(11-14)32-24(37)33-16-7-8-18(26)17(12-16)25(27,28)29/h2-4,7-13H,5-6H2,1H3,(H,35,36)(H,30,31,34)(H2,32,33,37) ZIRQSEOPGSAMHR-UHFFFAOYSA-N 50377761 CHEMBL430413 Serine/threonine-protein kinase B-raf Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2008.04.002 10.7270/Q2DJ5GH8 18434146 Wolin, RL; Bembenek, SD; Wei, J; Crawford, S; Lundeen, K; Brunmark, A; Karlsson, L; Edwards, JP; Blevitt, JM Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377761&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44448354 160856844 CHEMBL430413 ZINC29042643 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870202 Clc1ccc(CC(=O)Nc2cccc(c2)-c2[nH]c(nc2-c2ccnc(NCCN3CCNC3=O)n2)C2CC2)cc1 InChI=1S/C29H29ClN8O2/c30-21-8-4-18(5-9-21)16-24(39)34-22-3-1-2-20(17-22)25-26(37-27(36-25)19-6-7-19)23-10-11-31-28(35-23)32-12-14-38-15-13-33-29(38)40/h1-5,8-11,17,19H,6-7,12-16H2,(H,33,40)(H,34,39)(H,36,37)(H,31,32,35) CBZHOVUXXVXVNO-UHFFFAOYSA-N 50377767 CHEMBL429498 Serine/threonine-protein kinase B-raf Homo sapiens 7 ChEMBL 10.1016/j.bmcl.2008.04.002 10.7270/Q2DJ5GH8 18434146 Wolin, RL; Bembenek, SD; Wei, J; Crawford, S; Lundeen, K; Brunmark, A; Karlsson, L; Edwards, JP; Blevitt, JM Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377767&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 25066846 160856850 CHEMBL429498 ZINC29042492 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870203 FC(F)(F)c1nc(c([nH]1)-c1cccc(NC(=O)Cc2ccc(Cl)cc2)c1)-c1ccnc(NCCN2CCNC2=O)n1 InChI=1S/C27H24ClF3N8O2/c28-18-6-4-16(5-7-18)14-21(40)35-19-3-1-2-17(15-19)22-23(38-24(37-22)27(29,30)31)20-8-9-32-25(36-20)33-10-12-39-13-11-34-26(39)41/h1-9,15H,10-14H2,(H,34,41)(H,35,40)(H,37,38)(H,32,33,36) SGXJRYMLWWEIRD-UHFFFAOYSA-N 50377764 CHEMBL254965 Serine/threonine-protein kinase B-raf Homo sapiens 54 ChEMBL 10.1016/j.bmcl.2008.04.002 10.7270/Q2DJ5GH8 18434146 Wolin, RL; Bembenek, SD; Wei, J; Crawford, S; Lundeen, K; Brunmark, A; Karlsson, L; Edwards, JP; Blevitt, JM Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377764&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44448746 160856847 CHEMBL254965 ZINC29043716 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870204 CC(C)(C)NC(=O)NCCNc1nccc(n1)-c1nc([nH]c1-c1ccccc1Cl)C1CC1 InChI=1S/C23H28ClN7O/c1-23(2,3)31-22(32)27-13-12-26-21-25-11-10-17(28-21)19-18(15-6-4-5-7-16(15)24)29-20(30-19)14-8-9-14/h4-7,10-11,14H,8-9,12-13H2,1-3H3,(H,29,30)(H,25,26,28)(H2,27,31,32) BIEYPBBBEFDOTF-UHFFFAOYSA-N 50377770 CHEMBL257986 Serine/threonine-protein kinase B-raf Homo sapiens 83 ChEMBL 10.1016/j.bmcl.2008.04.002 10.7270/Q2DJ5GH8 18434146 Wolin, RL; Bembenek, SD; Wei, J; Crawford, S; Lundeen, K; Brunmark, A; Karlsson, L; Edwards, JP; Blevitt, JM Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377770&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44448669 160856853 CHEMBL257986 ZINC29043390 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870205 Clc1ccc(Cl)c(c1)-c1[nH]c(nc1-c1ccnc(NCCN2CCNC2=O)n1)C1CC1 InChI=1S/C21H21Cl2N7O/c22-13-3-4-15(23)14(11-13)17-18(29-19(28-17)12-1-2-12)16-5-6-24-20(27-16)25-7-9-30-10-8-26-21(30)31/h3-6,11-12H,1-2,7-10H2,(H,26,31)(H,28,29)(H,24,25,27) DCVHUXXSFGOVCQ-UHFFFAOYSA-N 50377771 CHEMBL401710 Serine/threonine-protein kinase B-raf Homo sapiens 10 ChEMBL 10.1016/j.bmcl.2008.04.002 10.7270/Q2DJ5GH8 18434146 Wolin, RL; Bembenek, SD; Wei, J; Crawford, S; Lundeen, K; Brunmark, A; Karlsson, L; Edwards, JP; Blevitt, JM Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377771&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44448666 160856854 CHEMBL401710 ZINC29043386 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870206 CNc1nccc(n1)-c1nc([nH]c1-c1cccc(NS(=O)(=O)Cc2ccc(Cl)c(Cl)c2)c1)C1CC1 InChI=1S/C24H22Cl2N6O2S/c1-27-24-28-10-9-20(29-24)22-21(30-23(31-22)15-6-7-15)16-3-2-4-17(12-16)32-35(33,34)13-14-5-8-18(25)19(26)11-14/h2-5,8-12,15,32H,6-7,13H2,1H3,(H,30,31)(H,27,28,29) WFHIMRZMKUCYOZ-UHFFFAOYSA-N 50377769 CHEMBL402029 Serine/threonine-protein kinase B-raf Homo sapiens 469 ChEMBL 10.1016/j.bmcl.2008.04.002 10.7270/Q2DJ5GH8 18434146 Wolin, RL; Bembenek, SD; Wei, J; Crawford, S; Lundeen, K; Brunmark, A; Karlsson, L; Edwards, JP; Blevitt, JM Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377769&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44448334 160856852 CHEMBL402029 ZINC29042576 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870207 NC(=O)c1cccc(Nc2nccc(n2)-c2nc([nH]c2-c2cccc(NS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)c2)C2CC2)c1 InChI=1S/C30H25Cl2N7O3S/c31-23-10-7-17(13-24(23)32)16-43(41,42)39-22-6-1-3-19(14-22)26-27(38-29(37-26)18-8-9-18)25-11-12-34-30(36-25)35-21-5-2-4-20(15-21)28(33)40/h1-7,10-15,18,39H,8-9,16H2,(H2,33,40)(H,37,38)(H,34,35,36) OCBCSZRKQIGAFJ-UHFFFAOYSA-N 50377768 CHEMBL402424 Serine/threonine-protein kinase B-raf Homo sapiens 887 ChEMBL 10.1016/j.bmcl.2008.04.002 10.7270/Q2DJ5GH8 18434146 Wolin, RL; Bembenek, SD; Wei, J; Crawford, S; Lundeen, K; Brunmark, A; Karlsson, L; Edwards, JP; Blevitt, JM Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377768&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44448311 160856851 CHEMBL402424 ZINC29042494 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870208 CNc1nccc(n1)-c1nc([nH]c1-c1cccc(NC(=O)Cc2ccc(Cl)cc2)c1)C1CC1 InChI=1S/C25H23ClN6O/c1-27-25-28-12-11-20(30-25)23-22(31-24(32-23)16-7-8-16)17-3-2-4-19(14-17)29-21(33)13-15-5-9-18(26)10-6-15/h2-6,9-12,14,16H,7-8,13H2,1H3,(H,29,33)(H,31,32)(H,27,28,30) RQXPEGZKAZRDBW-UHFFFAOYSA-N 50377766 CHEMBL403854 Serine/threonine-protein kinase B-raf Homo sapiens 9 ChEMBL 10.1016/j.bmcl.2008.04.002 10.7270/Q2DJ5GH8 18434146 Wolin, RL; Bembenek, SD; Wei, J; Crawford, S; Lundeen, K; Brunmark, A; Karlsson, L; Edwards, JP; Blevitt, JM Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377766&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44448747 160856849 CHEMBL403854 ZINC29043718 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870209 NC(=O)c1cccc(Nc2nccc(n2)-c2nc([nH]c2-c2cccc(NC(=O)Cc3ccc(Cl)cc3)c2)C2CC2)c1 InChI=1S/C31H26ClN7O2/c32-22-11-7-18(8-12-22)15-26(40)35-23-5-1-3-20(16-23)27-28(39-30(38-27)19-9-10-19)25-13-14-34-31(37-25)36-24-6-2-4-21(17-24)29(33)41/h1-8,11-14,16-17,19H,9-10,15H2,(H2,33,41)(H,35,40)(H,38,39)(H,34,36,37) DHKLNHJGUIVJOP-UHFFFAOYSA-N 50377765 CHEMBL254966 Serine/threonine-protein kinase B-raf Homo sapiens 4 ChEMBL 10.1016/j.bmcl.2008.04.002 10.7270/Q2DJ5GH8 18434146 Wolin, RL; Bembenek, SD; Wei, J; Crawford, S; Lundeen, K; Brunmark, A; Karlsson, L; Edwards, JP; Blevitt, JM Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377765&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44448748 160856848 CHEMBL254966 ZINC29043720 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870210 CNc1nccc(n1)-c1nc([nH]c1-c1cccc(NC(=O)Cc2ccc(Cl)cc2)c1)C(F)(F)F InChI=1S/C23H18ClF3N6O/c1-28-22-29-10-9-17(31-22)20-19(32-21(33-20)23(25,26)27)14-3-2-4-16(12-14)30-18(34)11-13-5-7-15(24)8-6-13/h2-10,12H,11H2,1H3,(H,30,34)(H,32,33)(H,28,29,31) YVQXWWGTOPSSIH-UHFFFAOYSA-N 50377763 CHEMBL258454 Serine/threonine-protein kinase B-raf Homo sapiens 30 ChEMBL 10.1016/j.bmcl.2008.04.002 10.7270/Q2DJ5GH8 18434146 Wolin, RL; Bembenek, SD; Wei, J; Crawford, S; Lundeen, K; Brunmark, A; Karlsson, L; Edwards, JP; Blevitt, JM Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377763&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44448725 160856846 CHEMBL258454 ZINC29043641 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870211 NC(=O)c1cccc(Nc2nccc(n2)-c2nc([nH]c2-c2cccc(NC(=O)Cc3ccc(Cl)cc3)c2)C(F)(F)F)c1 InChI=1S/C29H21ClF3N7O2/c30-19-9-7-16(8-10-19)13-23(41)36-20-5-1-3-17(14-20)24-25(40-27(39-24)29(31,32)33)22-11-12-35-28(38-22)37-21-6-2-4-18(15-21)26(34)42/h1-12,14-15H,13H2,(H2,34,42)(H,36,41)(H,39,40)(H,35,37,38) ZDWXGFSUCOUHQJ-UHFFFAOYSA-N 50377762 CHEMBL256775 Serine/threonine-protein kinase B-raf Homo sapiens 108 ChEMBL 10.1016/j.bmcl.2008.04.002 10.7270/Q2DJ5GH8 18434146 Wolin, RL; Bembenek, SD; Wei, J; Crawford, S; Lundeen, K; Brunmark, A; Karlsson, L; Edwards, JP; Blevitt, JM Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377762&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44448726 160856845 CHEMBL256775 ZINC29043643 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50870212 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2008.04.002 10.7270/Q2DJ5GH8 18434146 Wolin, RL; Bembenek, SD; Wei, J; Crawford, S; Lundeen, K; Brunmark, A; Karlsson, L; Edwards, JP; Blevitt, JM Johnson & Johnson Pharmaceutical Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50862600 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc1 InChI=1S/C31H30N8O/c1-20-7-6-8-21(2)27(20)39-29(40)24-19-32-30(35-28(24)38-26-10-5-4-9-25(26)34-31(38)39)33-22-11-13-23(14-12-22)37-17-15-36(3)16-18-37/h4-14,19H,15-18H2,1-3H3,(H,32,33,35) BHJJWVDKNXABFS-UHFFFAOYSA-N 50374608 CHEMBL410295 Serine/threonine-protein kinase B-raf Homo sapiens 540 ChEMBL 10.1021/jm701095m 10.7270/Q23B6114 18278858 Martin, MW; Newcomb, J; Nunes, JJ; Boucher, C; Chai, L; Epstein, LF; Faust, T; Flores, S; Gallant, P; Gore, A; Gu, Y; Hsieh, F; Huang, X; Kim, JL; Middleton, S; Morgenstern, K; Oliveira-dos-Santos, A; Patel, VF; Powers, D; Rose, P; Tudor, Y; Turci, SM; Welcher, AA; Zack, D; Zhao, H; Zhu, L; Zhu, X; Ghiron, C; Ermann, M; Johnston, D; Saluste, CG Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374608&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search AM9 3BYO 11785878 160853698 CHEMBL410295 ZINC53214756 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50885126 OC1Nc2ccc(I)cc2C1=Cc1cc(Br)c(O)c(Br)c1 InChI=1S/C15H10Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,15,19-21H UFKSWYKDQZBJTH-UHFFFAOYSA-N 50358043 CHEMBL1794051::GW-5074 Serine/threonine-protein kinase B-raf Homo sapiens 190 ChEMBL 10.1042/BJ20070797 10.7270/Q27082B4 17850214 Bain, J; Plater, L; Elliott, M; Shpiro, N; Hastie, CJ; McLauchlan, H; Klevernic, I; Arthur, JS; Alessi, DR; Cohen, P University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358043&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 56674921 136962067 CHEMBL1794051 ZINC72134204 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50885140 CN(C)c1cccc(c1)C(=O)Nc1ccc(C)c(NC(=O)c2ccc(O)cc2)c1 InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28) PYEFPDQFAZNXLI-UHFFFAOYSA-N 50153835 1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyphenylcarboxamido)-4-methylbenzene::3-(dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamide::CHEMBL186526::N-[5-(3-dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide::ZM-336372 Serine/threonine-protein kinase B-raf Homo sapiens 230 ChEMBL 10.1042/BJ20070797 10.7270/Q27082B4 17850214 Bain, J; Plater, L; Elliott, M; Shpiro, N; Hastie, CJ; McLauchlan, H; Klevernic, I; Arthur, JS; Alessi, DR; Cohen, P University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153835&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 5730 104041586 CHEMBL186526 ZINC00581684 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50885141 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 7300 ChEMBL 10.1042/BJ20070797 10.7270/Q27082B4 17850214 Bain, J; Plater, L; Elliott, M; Shpiro, N; Hastie, CJ; McLauchlan, H; Klevernic, I; Arthur, JS; Alessi, DR; Cohen, P University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890644 COCC(=O)NC\C=C\c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1 InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+ LLVZBTWPGQVVLW-SNAWJCMRSA-N 31340 2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridyl)oxy]anilino]quinazolin-6-yl]allyl]acetamide::2-methoxy-N-[(E)-3-[4-[[3-methyl-4-(6-methylpyridin-3-yl)oxy-phenyl]amino]quinazolin-6-yl]prop-2-enyl]ethanamide::CHEMBL483321::CP-724714::cid_9874913 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31340&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9874913 252615341 CHEMBL483321 ZINC03817105 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890648 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Serine/threonine-protein kinase B-raf Homo sapiens 1700 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890650 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890652 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890655 Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) QHKYPYXTTXKZST-UHFFFAOYSA-N 13531 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190 Serine/threonine-protein kinase B-raf Homo sapiens 4800 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13531&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 5353940 172097219 ZINC14951176 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890657 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Serine/threonine-protein kinase B-raf Homo sapiens 730 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890659 CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+ WVUNYSQLFKLYNI-AATRIKPKSA-N 31090 (E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-3-cyano-7-ethoxy-quinolin-6-yl]-4-(dimethylamino)but-2-enamide::EKB-569::Pelitinib::cid_6445562 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31090&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 93J 7AXM,5VCW 6445562 252615337 38927 ZINC00602803 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890660 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890661 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) KDKUVYLMPJIGKA-UHFFFAOYSA-N 6866 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b::4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide::CHEMBL191003::JNJ-7706621::cid_5330790 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6866&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search SKE 5WIN,5USZ,5USY,5DR9,8B99,5OBR,6DRW,5DPV,5DR6,6P11,6P10,3AMA,4QMU,5DT0 5330790 8036422 CHEMBL191003 ZINC03938688 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890662 NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCOc2c1)-c1ccccn1 InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26) FHYUGAJXYORMHI-UHFFFAOYSA-N 50110208 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(4-Benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::4-(5-(benzo[d][1,3]dioxol-5-yl)-4-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(5-benzo[1,3]dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::CHEMBL440084::SB-431542::cid_4521392 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110208&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 085 3TZM 4521392 104005054 CHEMBL440084 ZINC00603769 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890663 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890664 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890667 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Serine/threonine-protein kinase B-raf Homo sapiens 710 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890668 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890669 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Serine/threonine-protein kinase B-raf Homo sapiens 2900 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890671 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Serine/threonine-protein kinase B-raf Homo sapiens 630 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890672 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890673 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890676 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890679 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Serine/threonine-protein kinase B-raf Homo sapiens 1200 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890681 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890684 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890688 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890692 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Serine/threonine-protein kinase B-raf Homo sapiens 570 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890696 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890697 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50890698 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50899061 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Serine/threonine-protein kinase B-raf Homo sapiens 3300 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50899064 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50899065 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50899069 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50899074 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 260 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50899076 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50899077 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50899079 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50899080 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50917516 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 22 ChEMBL 10.1016/j.chembiol.2005.04.011 10.7270/Q2R49RR6 15975507 Knight, ZA; Shokat, KM University of California San Francisco http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50924839 Nc1c(c(nn1-c1c(Cl)cc(Cl)cc1Cl)-c1ccncc1)-c1ccc(F)cc1 InChI=1S/C20H12Cl3FN4/c21-13-9-15(22)19(16(23)10-13)28-20(25)17(11-1-3-14(24)4-2-11)18(27-28)12-5-7-26-8-6-12/h1-10H,25H2 MOHYPRXHKRXDSE-UHFFFAOYSA-N 50379214 CHEMBL2011291::US9416123, 6 Serine/threonine-protein kinase B-raf Homo sapiens 270 ChEMBL 10.1021/jm201391u 10.7270/Q2FT8N18 22185282 Abu Thaher, B; Arnsmann, M; Totzke, F; Ehlert, JE; Kubbutat, MH; Schachtele, C; Zimmermann, MO; Koch, P; Boeckler, FM; Laufer, SA Islamic University of Gaza http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379214&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 56924694 160858297 CHEMBL2011291 ZINC84604180 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50933437 COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C(F)(F)F)c3)c2cc1OC InChI=1S/C24H22F3N5O5/c1-23(2,24(25,26)27)19-11-20(32-37-19)31-22(33)30-13-6-5-7-14(8-13)36-21-15-9-17(34-3)18(35-4)10-16(15)28-12-29-21/h5-12H,1-4H3,(H2,30,31,32,33) DKNUPRMJNUQNHR-UHFFFAOYSA-N 50382959 CEP-32496::CHEMBL2029988::US9730937, Example 261 Serine/threonine-protein kinase B-raf Homo sapiens 36 ChEMBL 10.1021/jm2009925 10.7270/Q2571D2T 22168626 Rowbottom, MW; Faraoni, R; Chao, Q; Campbell, BT; Lai, AG; Setti, E; Ezawa, M; Sprankle, KG; Abraham, S; Tran, L; Struss, B; Gibney, M; Armstrong, RC; Gunawardane, RN; Nepomuceno, RR; Valenta, I; Hua, H; Gardner, MF; Cramer, MD; Gitnick, D; Insko, DE; Apuy, JL; Jones-Bolin, S; Ghose, AK; Herbertz, T; Ator, MA; Dorsey, BD; Ruggeri, B; Williams, M; Bhagwat, S; James, J; Holladay, MW Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50382959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50382959&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 56846693 160862042 CHEMBL2029988 ZINC43207440 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50942354 Nc1ncnc2c(csc12)C(=O)Nc1c(Cl)ccc(NS(=O)(=O)CCCF)c1F InChI=1S/C16H14ClF2N5O3S2/c17-9-2-3-10(24-29(26,27)5-1-4-18)11(19)13(9)23-16(25)8-6-28-14-12(8)21-7-22-15(14)20/h2-3,6-7,24H,1,4-5H2,(H,23,25)(H2,20,21,22) DFIVZWWMRMZVLA-UHFFFAOYSA-N 50386475 CHEMBL2047879 Serine/threonine-protein kinase B-raf Homo sapiens 22 ChEMBL 10.1021/jm300016v 10.7270/Q2XP7601 22335519 Mathieu, S; Gradl, SN; Ren, L; Wen, Z; Aliagas, I; Gunzner-Toste, J; Lee, W; Pulk, R; Zhao, G; Alicke, B; Boggs, JW; Buckmelter, AJ; Choo, EF; Dinkel, V; Gloor, SL; Gould, SE; Hansen, JD; Hastings, G; Hatzivassiliou, G; Laird, ER; Moreno, D; Ran, Y; Voegtli, WC; Wenglowsky, S; Grina, J; Rudolph, J Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386475&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57343225 160865558 CHEMBL2047879 ZINC84669769 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943844 CCCNS(=O)(=O)c1ccc2[nH]c3c(nccc3c2c1)C(N)=O InChI=1S/C15H16N4O3S/c1-2-6-18-23(21,22)9-3-4-12-11(8-9)10-5-7-17-14(15(16)20)13(10)19-12/h3-5,7-8,18-19H,2,6H2,1H3,(H2,16,20) ZRYOOTLANCRZRZ-UHFFFAOYSA-N 50387066 CHEMBL2047056 Serine/threonine-protein kinase B-raf Homo sapiens 28510 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387066&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53380221 160866149 CHEMBL2047056 ZINC84652933 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943845 CCN(CC)CCCNS(=O)(=O)c1ccc2[nH]c3c(nccc3c2c1)C(N)=O InChI=1S/C19H25N5O3S/c1-3-24(4-2)11-5-9-22-28(26,27)13-6-7-16-15(12-13)14-8-10-21-18(19(20)25)17(14)23-16/h6-8,10,12,22-23H,3-5,9,11H2,1-2H3,(H2,20,25) CNEVGZBJBUCYKK-UHFFFAOYSA-N 50387067 CHEMBL2047057 Serine/threonine-protein kinase B-raf Homo sapiens 2810 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387067&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53380323 160866150 CHEMBL2047057 ZINC84759279 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943846 NC(=O)c1nccc2c3cc(ccc3[nH]c12)S(=O)(=O)NCCCO InChI=1S/C15H16N4O4S/c16-15(21)14-13-10(4-6-17-14)11-8-9(2-3-12(11)19-13)24(22,23)18-5-1-7-20/h2-4,6,8,18-20H,1,5,7H2,(H2,16,21) KYLMKWTYFMIVSF-UHFFFAOYSA-N 50387068 CHEMBL2047058 Serine/threonine-protein kinase B-raf Homo sapiens 20500 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387068&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53380319 160866151 CHEMBL2047058 ZINC84652934 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943847 CC(O)CNS(=O)(=O)c1ccc2[nH]c3c(nccc3c2c1)C(N)=O InChI=1S/C15H16N4O4S/c1-8(20)7-18-24(22,23)9-2-3-12-11(6-9)10-4-5-17-14(15(16)21)13(10)19-12/h2-6,8,18-20H,7H2,1H3,(H2,16,21) XCLLUIUISMQEBF-UHFFFAOYSA-N 50387069 CHEMBL2047059 Serine/threonine-protein kinase B-raf Homo sapiens 21990 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387069&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53380318 160866152 CHEMBL2047059 ZINC84653378 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943848 CN(C)CCCNS(=O)(=O)c1ccc2[nH]c3c(nccc3c2c1)C(N)=O InChI=1S/C17H21N5O3S/c1-22(2)9-3-7-20-26(24,25)11-4-5-14-13(10-11)12-6-8-19-16(17(18)23)15(12)21-14/h4-6,8,10,20-21H,3,7,9H2,1-2H3,(H2,18,23) PVMSHPHURUQKQQ-UHFFFAOYSA-N 50387070 CHEMBL2047060 Serine/threonine-protein kinase B-raf Homo sapiens 1620 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387070&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53380322 160866153 CHEMBL2047060 ZINC84756805 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943849 COC(CNS(=O)(=O)c1ccc2[nH]c3c(nccc3c2c1)C(N)=O)OC InChI=1S/C16H18N4O5S/c1-24-13(25-2)8-19-26(22,23)9-3-4-12-11(7-9)10-5-6-18-15(16(17)21)14(10)20-12/h3-7,13,19-20H,8H2,1-2H3,(H2,17,21) OPOGZVOLWPBAMY-UHFFFAOYSA-N 50387071 CHEMBL2047061 Serine/threonine-protein kinase B-raf Homo sapiens 91550 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387071&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53380320 160866154 CHEMBL2047061 ZINC84756807 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943850 NC(=O)c1nccc2c3cc(ccc3[nH]c12)S(=O)(=O)NCC(O)CO InChI=1S/C15H16N4O5S/c16-15(22)14-13-10(3-4-17-14)11-5-9(1-2-12(11)19-13)25(23,24)18-6-8(21)7-20/h1-5,8,18-21H,6-7H2,(H2,16,22) ISNLRLPZWXJDSI-UHFFFAOYSA-N 50387072 CHEMBL2047062 Serine/threonine-protein kinase B-raf Homo sapiens 45090 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387072&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53380219 160866155 CHEMBL2047062 ZINC84756810 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943851 NC(=O)c1nccc2c3cc(ccc3[nH]c12)S(=O)(=O)NCCO InChI=1S/C14H14N4O4S/c15-14(20)13-12-9(3-4-16-13)10-7-8(1-2-11(10)18-12)23(21,22)17-5-6-19/h1-4,7,17-19H,5-6H2,(H2,15,20) KOTFFBMTBPVTJV-UHFFFAOYSA-N 50387073 CHEMBL2047063 Serine/threonine-protein kinase B-raf Homo sapiens 23740 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387073&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44479262 160866156 CHEMBL2047063 ZINC84756811 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943852 COCCCNS(=O)(=O)c1ccc2[nH]c3c(nccc3c2c1)C(N)=O InChI=1S/C16H18N4O4S/c1-24-8-2-6-19-25(22,23)10-3-4-13-12(9-10)11-5-7-18-15(16(17)21)14(11)20-13/h3-5,7,9,19-20H,2,6,8H2,1H3,(H2,17,21) RZFWAOFCKVPXGT-UHFFFAOYSA-N 50387074 CHEMBL2047064 Serine/threonine-protein kinase B-raf Homo sapiens 22650 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387074&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53380218 160866157 CHEMBL2047064 ZINC84758547 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943853 NC(=O)c1nccc2c3cc(ccc3[nH]c12)S(=O)(=O)NC1CC1 InChI=1S/C15H14N4O3S/c16-15(20)14-13-10(5-6-17-14)11-7-9(3-4-12(11)18-13)23(21,22)19-8-1-2-8/h3-8,18-19H,1-2H2,(H2,16,20) VBFHGPQBIFPEJI-UHFFFAOYSA-N 50387075 CHEMBL2047065 Serine/threonine-protein kinase B-raf Homo sapiens 9070 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387075&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53380119 160866158 CHEMBL2047065 ZINC84758550 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943854 NC(=O)c1nccc2c3cc(ccc3[nH]c12)S(=O)(=O)Nc1ccccc1 InChI=1S/C18H14N4O3S/c19-18(23)17-16-13(8-9-20-17)14-10-12(6-7-15(14)21-16)26(24,25)22-11-4-2-1-3-5-11/h1-10,21-22H,(H2,19,23) QUNBGRFIZJUZTF-UHFFFAOYSA-N 50387076 CHEMBL2047066 Serine/threonine-protein kinase B-raf Homo sapiens 2740 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387076&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44479517 160866159 CHEMBL2047066 ZINC84758552 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943855 Cc1ccc(NS(=O)(=O)c2ccc3[nH]c4c(nccc4c3c2)C(N)=O)cc1 InChI=1S/C19H16N4O3S/c1-11-2-4-12(5-3-11)23-27(25,26)13-6-7-16-15(10-13)14-8-9-21-18(19(20)24)17(14)22-16/h2-10,22-23H,1H3,(H2,20,24) QQIQKXOWEGLEFU-UHFFFAOYSA-N 50387077 CHEMBL2047067 Serine/threonine-protein kinase B-raf Homo sapiens 13540 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387077&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53380120 160866160 CHEMBL2047067 ZINC84758555 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943856 NC(=O)c1nccc2c3cc(ccc3[nH]c12)S(=O)(=O)Nc1ccc(F)cc1 InChI=1S/C18H13FN4O3S/c19-10-1-3-11(4-2-10)23-27(25,26)12-5-6-15-14(9-12)13-7-8-21-17(18(20)24)16(13)22-15/h1-9,22-23H,(H2,20,24) QJZLPNVSDFBNIH-UHFFFAOYSA-N 50387078 CHEMBL2047068 Serine/threonine-protein kinase B-raf Homo sapiens 8890 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387078&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53380324 160866161 CHEMBL2047068 ZINC84671542 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943857 NC(=O)c1nccc2c3cc(ccc3[nH]c12)S(=O)(=O)Nc1ccccn1 InChI=1S/C17H13N5O3S/c18-17(23)16-15-11(6-8-20-16)12-9-10(4-5-13(12)21-15)26(24,25)22-14-3-1-2-7-19-14/h1-9,21H,(H2,18,23)(H,19,22) HTDIOMWIPPPMNP-UHFFFAOYSA-N 50387079 CHEMBL2047069 Serine/threonine-protein kinase B-raf Homo sapiens 3760 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387079&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53380121 160866162 CHEMBL2047069 ZINC84670160 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943858 NC(=O)c1nccc2c3cc(ccc3[nH]c12)S(N)(=O)=O InChI=1S/C12H10N4O3S/c13-12(17)11-10-7(3-4-15-11)8-5-6(20(14,18)19)1-2-9(8)16-10/h1-5,16H,(H2,13,17)(H2,14,18,19) FRNSVGQTSZMFIW-UHFFFAOYSA-N 50387080 CHEMBL2047071 Serine/threonine-protein kinase B-raf Homo sapiens 2120 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387080&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44479258 160866163 CHEMBL2047071 ZINC84670161 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943859 NS(=O)(=O)c1ccc2[nH]c3cnccc3c2c1 InChI=1S/C11H9N3O2S/c12-17(15,16)7-1-2-10-9(5-7)8-3-4-13-6-11(8)14-10/h1-6,14H,(H2,12,15,16) RDEJANIUMKOOCX-UHFFFAOYSA-N 50387081 CHEMBL2047072 Serine/threonine-protein kinase B-raf Homo sapiens 2490 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387081&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53379548 160866164 CHEMBL2047072 ZINC84670162 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943860 CC(=O)NS(=O)(=O)c1ccc2[nH]c3cnccc3c2c1 InChI=1S/C13H11N3O3S/c1-8(17)16-20(18,19)9-2-3-12-11(6-9)10-4-5-14-7-13(10)15-12/h2-7,15H,1H3,(H,16,17) YNZGRWFQZAKEQF-UHFFFAOYSA-N 50387082 CHEMBL2047073 Serine/threonine-protein kinase B-raf Homo sapiens 59110 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387082&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 53379553 160866165 CHEMBL2047073 ZINC84669193 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943861 NC(=O)c1nccc2c3cc(ccc3[nH]c12)S(=O)(=O)Nc1nccs1 InChI=1S/C15H11N5O3S2/c16-14(21)13-12-9(3-4-17-13)10-7-8(1-2-11(10)19-12)25(22,23)20-15-18-5-6-24-15/h1-7,19H,(H2,16,21)(H,18,20) BNGYTNLZEGJRDT-UHFFFAOYSA-N 50387083 CHEMBL2047070 Serine/threonine-protein kinase B-raf Homo sapiens 7480 ChEMBL 10.1016/j.bmcl.2012.05.053 10.7270/Q2H9967D 22704238 Xin, B; Tang, W; Wang, Y; Lin, G; Liu, H; Jiao, Y; Zhu, Y; Yuan, H; Chen, Y; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387083&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 70681940 160866166 CHEMBL2047070 ZINC84668617 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50943042 CC(C)(N)C(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc5sncc45)c(Cl)c3)c12 InChI=1S/C25H24ClN7O2S/c1-25(2,27)24(34)28-9-11-33-10-8-18-22(33)23(30-14-29-18)32-15-6-7-20(17(26)12-15)35-19-4-3-5-21-16(19)13-31-36-21/h3-8,10,12-14H,9,11,27H2,1-2H3,(H,28,34)(H,29,30,32) AVHNHPHSQMBYAJ-UHFFFAOYSA-N 50386693 CHEMBL2048912 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1021/jm300185p 10.7270/Q2474BX1 22439974 Kawakita, Y; Banno, H; Ohashi, T; Tamura, T; Yusa, T; Nakayama, A; Miki, H; Iwata, H; Kamiguchi, H; Tanaka, T; Habuka, N; Sogabe, S; Ohta, Y; Ishikawa, T Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386693&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 44229839 160865776 CHEMBL2048912 ZINC43208438 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50939672 CN(C)CCOc1ccc(cc1)-c1nc(c([nH]1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1 InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,24H,6,10,15-16H2,1-2H3,(H,29,30) ZLWRKMXLUCZVAR-UHFFFAOYSA-N 25391 CHEMBL200622::SB-590885::SB590885::[2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)-1H-imidazol-2-yl}phenoxy)ethyl]dimethylamine Serine/threonine-protein kinase B-raf Homo sapiens 0.16 ChEMBL 10.1016/j.bmc.2012.04.047 10.7270/Q2QF8TXP 22583669 Li, CY; Li, QS; Yan, L; Sun, XG; Wei, R; Gong, HB; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25391&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2FB8 91369525 56374530 CHEMBL200622 ZINC89224159 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50954390 CC(C)(C(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(Cl)c4)c(Cl)c3)c12)S(C)(=O)=O InChI=1S/C25H25Cl2N5O4S/c1-25(2,37(3,34)35)24(33)28-10-12-32-11-9-20-22(32)23(30-15-29-20)31-17-7-8-21(19(27)14-17)36-18-6-4-5-16(26)13-18/h4-9,11,13-15H,10,12H2,1-3H3,(H,28,33)(H,29,30,31) UVBKNBPCVRBUTF-UHFFFAOYSA-N 50391643 CHEMBL2148052::CHEMBL2148053 Serine/threonine-protein kinase B-raf Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2012.08.002 10.7270/Q21R6RMZ 22980219 Kawakita, Y; Miwa, K; Seto, M; Banno, H; Ohta, Y; Tamura, T; Yusa, T; Miki, H; Kamiguchi, H; Ikeda, Y; Tanaka, T; Kamiyama, K; Ishikawa, T Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391643&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 57496699 163340667 CHEMBL2148052CHEMBL2148053 ZINC43153603 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50966766 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) GPXBXXGIAQBQNI-UHFFFAOYSA-N 50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB Serine/threonine-protein kinase B-raf Homo sapiens 100 ChEMBL 10.1021/jm300613w 10.7270/Q29K4CC8 22808911 Wang, X; Kim, J Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396483&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 032 3OG7,5HES,4RZV 42611257 163345507 63637 DB08881 ZINC52509366 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50966768 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase B-raf Homo sapiens 22 ChEMBL 10.1021/jm300613w 10.7270/Q29K4CC8 22808911 Wang, X; Kim, J Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50966770 Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1Nc1ncccc1-c1ncnc2nc[nH]c12 InChI=1S/C26H19ClN8/c1-15-4-9-19-18(10-12-29-24(19)34-17-7-5-16(27)6-8-17)21(15)35-25-20(3-2-11-28-25)22-23-26(32-13-30-22)33-14-31-23/h2-14H,1H3,(H,28,35)(H,29,34)(H,30,31,32,33) KKVYYGGCHJGEFJ-UHFFFAOYSA-N 35327 pyridylpurine aminoisoquinoline, 1 Serine/threonine-protein kinase B-raf Homo sapiens 2 ChEMBL 10.1021/jm300613w 10.7270/Q29K4CC8 22808911 Wang, X; Kim, J Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35327&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search L1E 3IDP 44223999 85753403 ZINC39300628 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50966771 CN(C)CCOc1ccc(cc1)-c1nc(c([nH]1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1 InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,24H,6,10,15-16H2,1-2H3,(H,29,30) ZLWRKMXLUCZVAR-UHFFFAOYSA-N 25391 CHEMBL200622::SB-590885::SB590885::[2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)-1H-imidazol-2-yl}phenoxy)ethyl]dimethylamine Serine/threonine-protein kinase B-raf Homo sapiens 290 ChEMBL 10.1021/jm300613w 10.7270/Q29K4CC8 22808911 Wang, X; Kim, J Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25391&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 2FB8 91369525 56374530 CHEMBL200622 ZINC89224159 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50966776 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) YZDJQTHVDDOVHR-UHFFFAOYSA-N 25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720 Serine/threonine-protein kinase B-raf Homo sapiens 2.6 ChEMBL 10.1021/jm300613w 10.7270/Q29K4CC8 22808911 Wang, X; Kim, J Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2857&target=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25617&enzyme=Serine%2Fthreonine-protein+kinase+B-raf&column=ki&startPg=0&Increment=50&submit=Search 324 3C4C,4WO5 24180719 56412907 DB06999 5703 ZINC39059267 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 2FB8,2L05,3D4Q,3II5,3NY5,3PPJ,3PPK,3PRF,3PRI,3PSB,3PSD,3Q4C,3Q96,3SKC,3TV4,3TV6,4DBN,4E26,4E4X,4EHE,4FC0,4G9C,4H58,4KSP,4KSQ,4MBJ,4MNE,4PP7,4XV1,4XV2,4XV3,5CT7,5FD2,5VAL,5VAM,5VR3,5VYK,6B8U,6N0P,6N0Q,6NYB,6Q0K,6U2G,6V34,7MFD,7MFE,7MFF,7SHV,8DGS,8DGT Serine/threonine-protein kinase B-raf BRAF_HUMAN P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3 50966778 OCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,18,24H,2,4,9-10H2 RIGIGAFKKVBACY-UHFFFAOYSA-N 25628 2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethan-1-ol::AR00341677::CHEMBL525191::GDC-0879 Serine/threonine-protein kinase B-raf Homo sapiens 0.17 ChEMBL 10.1021/jm300613w 10.7270/Q29K4CC8 22808911 Wang, X; Kim, J Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25628 http://www.bindin